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1. Lifespan prolonging mechanisms and insulin upregulation without fat accumulation in long-lived reproductives of a higher termite

Author: Sarah Séité, Mark C. Harrison, David Sillam-Dussès, Roland Lupoli, Tom J. M. Van Dooren, Alain Robert, Laure-Anne Poissonnier, Arnaud Lemainque, David Renault, Sébastien Acket, Muriel Andrieu, José Viscarra, Hei Sook Sul, Z. Wilhelm de Beer, Erich Bornberg-Bauer, and Mireille Vasseur-Cognet
Subjects: Biology (General), QH301-705.5
Abstract: Séité, Harrison, et al. investigate the mechanisms underlying long lifespan in queens and kings of the highly social termite Macrotermes natalensis. Using transcriptomics, lipidomics and metabolomics, this study shows that several aging-related processes are reduced in the fat bodies of these reproductives and that an upregulated insulin-like peptide, Ilp9, does not lead to deleterious fat storage in old queens, while simple sugars dominate in their hemolymph.
Published: 2022
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2. Continuous enteral nutrition compared with a maximal gastric vacuity strategy at the time of extubation in the intensive care unit: protocol for a non-inferiority cluster randomised trial (the Ambroisie Project)

Author: Bruno Giraudeau, Stephan Ehrmann, Arnaud W Thille, Alain Robert, Mai-Anh Nay, Elsa Tavernier, Jean Reignier, Mickael Landais, Johann Auchabie, Noemie Hubert, and Anne Rebion
Subjects: Medicine
Abstract: Introduction Fasting is frequently imposed to patients before extubation in the intensive care unit based on scheduled surgery guidelines. This practice has never been evaluated among critically ill patients and may delay extubation, increase nursing workload and reduce caloric intake. We are hypothesising that continuous enteral nutrition until extubation represents a safe alternative compared with fasting prior to extubation in the intensive care unit.Methods and analysis Adult patients ventilated more than 48 hours and receiving pre-pyloric enteral nutrition for more than 24 hours are included in this open-label cluster randomised parallel group non-inferiority trial. The participating centres are randomised allocated to continued enteral nutrition until extubation or 6-hour fasting (with concomitant gastric suctioning when feasible) prior to extubation. The primary outcome is extubation failure (ie, reintubation within 7 days following extubation).Ethics and dissemination This study has been approved by the national ethics review board (comité de protection, des personnes Sud Mediterranée III No 2017.10.02 bis) and patients are included after informed consent. Results will be submitted for publication in peer-reviewed journals.Trial registration number ClinicalTrials.gov Registry (NCT03335345).
Published: 2021
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3. Mycotoxins Exposure of French Grain Elevator Workers: Biomonitoring and Airborne Measurements

Author: Sophie Ndaw, Aurélie Remy, Danièle Jargot, Guillaume Antoine, Flavien Denis, and Alain Robert
Subjects: mycotoxins, exposure assessment, biomonitoring, air, dust, HR-MS/MS, Medicine
Abstract: It is now recognized that additional exposure to mycotoxins may occur through inhalation of contaminated dust at a workplace. The aim of this study was to characterize the multi-mycotoxin exposure of French grain elevator workers using biomonitoring and airborne measurements. Eighteen workers participated in the study. Personal airborne dust samples were analyzed for their mycotoxin concentrations. Workers provided multiple urine samples including pre-shift, post-shift and first morning urine samples or 24 h urine samples. Mycotoxin urinary biomarkers (aflatoxin B1, aflatoxin M1, ochratoxin A, ochratoxin α, deoxynivalenol, zearalenone, α-zearalenol, β-zearalenol, fumonisin B1, HT-2 toxin and T-2 toxin) were measured using a liquid chromatography–high-resolution mass spectrometry method. Grain elevator workers were highly exposed to organic airborne dust (median 4.92 mg.m−3). DON, ZEN and FB1 were frequent contaminants in 54, 76 and 72% of air samples, respectively. The mycotoxin biomarkers quantified were DON (98%), ZEN (99%), α-ZEL (52%), β-ZEL (33%), OTA (76%), T-2 (4%) and HT-2 (4%). DON elimination profiles showed highest concentrations in samples collected after the end of the work shift and the urinary DON concentrations were significantly higher in post-shift than in pre-shift-samples (9.9 and 22.1 µg/L, respectively). ZEN and its metabolites concentrations did not vary according to the sampling time. However, the levels of α-/β-ZEL were consistent with an additional occupational exposure. These data provide valuable information on grain worker exposure to mycotoxins. They also highlight the usefulness of multi-mycotoxin methods in assessing external and internal exposures, which shed light on the extent and pathways of exposure occurring in occupational settings.
Published: 2021
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4. Investigating Multi-Mycotoxin Exposure in Occupational Settings: A Biomonitoring and Airborne Measurement Approach

Author: Sophie Ndaw, Daniele Jargot, Guillaume Antoine, Flavien Denis, Sandrine Melin, and Alain Robert
Subjects: mycotoxins, exposure assessment, biomonitoring, air, dust, HR-MS/MS, Medicine
Abstract: Investigating workplace exposure to mycotoxins is of the utmost importance in supporting the implementation of preventive measures for workers. The aim of this study was to provide tools for measuring mycotoxins in urine and airborne samples. A multi-class mycotoxin method was developed in urine for the determination of aflatoxin B1, aflatoxin M1, ochratoxin A, ochratoxin α, deoxynivalenol, zearalenone, α-zearalenol, β-zearalenol, fumonisin B1, HT2-toxin and T2-toxin. Analysis was based on liquid chromatography–high resolution mass spectrometry. Sample pre-treatments included enzymatic digestion and an online or offline sample clean-up step. The method was validated according to the European Medicines Agency guidance procedures. In order to estimate external exposure, air samples collected with a CIP 10 (Capteur Individuel de Particules 10) personal dust sampler were analyzed for the quantification of up to ten mycotoxins, including aflatoxins, ochratoxin A, deoxynivalenol, zearalenone, fumonisin B1 and HT-2 toxin and T-2 toxin. The method was validated according to standards for workplace exposure to chemical and biological agents EN 482. Both methods, biomonitoring and airborne mycotoxin measurement, showed good analytical performances. They were successfully applied in a small pilot study to assess mycotoxin contamination in workers during cleaning of a grain elevator. We demonstrated that this approach was suitable for investigating occupational exposure to mycotoxins.
Published: 2021
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5. Nitrous Oxide (N2O) Emissions by Termites: Does the Feeding Guild Matter?

Author: Alain Brauman, Muhammad Zeeshan Majeed, Bruno Buatois, Alain Robert, Anne-Laure Pablo, and Edouard Miambi
Subjects: Medicine, Science
Abstract: In the tropics, termites are major players in the mineralization of organic matter leading to the production of greenhouse gases including nitrous oxide (N2O). Termites have a wide trophic diversity and their N-metabolism depends on the feeding guild. This study assessed the extent to which N2O emission levels were determined by termite feeding guild and tested the hypothesis that termite species feeding on a diet rich in N emit higher levels of N2O than those feeding on a diet low in N. An in-vitro incubation approach was used to determine the levels of N2O production in 14 termite species belonging to different feeding guilds, collected from a wide range of biomes. Fungus-growing and soil-feeding termites emit N2O. The N2O production levels varied considerably, ranging from 13.14 to 117.62 ng N2O-N d(-1) (g dry wt.)(-1) for soil-feeding species, with Cubitermes spp. having the highest production levels, and from 39.61 to 65.61 ng N2O-N d(-1) (g dry wt.)(-1) for fungus-growing species. Wood-feeding termites were net N2O consumers rather than N2O producers with a consumption ranging from 16.09 to 45.22 ng N2O-N d(-1) (g dry wt.)(-1). Incubating live termites together with their mound increased the levels of N2O production by between 6 and 13 fold for soil-feeders, with the highest increase in Capritermes capricornis, and between 14 and 34 fold for fungus-growers, with the highest increase in Macrotermes muelleri. Ammonia-oxidizing (amoA-AOB and amoA-AOA) and denitrifying (nirK, nirS, nosZ) gene markers were detected in the guts of all termite species studied. No correlation was found between the abundance of these marker genes and the levels of N2O production from different feeding guilds. Overall, these results support the hypothesis that N2O production rates were higher in termites feeding on substrates with higher N content, such as soil and fungi, compared to those feeding on N-poor wood.
Published: 2015
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6. The respiratory syncytial virus G protein conserved domain induces a persistent and protective antibody response in rodents.

Author: Thien N Nguyen, Ultan F Power, Alain Robert, Jean-François Haeuw, Katia Helffer, Amadeo Perez, Miguel-Angel Asin, Nathalie Corvaia, and Christine Libon
Subjects: Medicine, Science
Abstract: Respiratory syncytial virus (RSV) is an important cause of severe upper and lower respiratory disease in infants and in the elderly. There are 2 main RSV subtypes A and B. A recombinant vaccine was designed based on the central domain of the RSV-A attachment G protein which we had previously named G2Na (aa130-230). Here we evaluated immunogenicity, persistence of antibody (Ab) response and protective efficacy induced in rodents by: (i) G2Na fused to DT (Diphtheria toxin) fragments in cotton rats. DT fusion did not potentiate neutralizing Ab responses against RSV-A or cross-reactivity to RSV-B. (ii) G2Nb (aa130-230 of the RSV-B G protein) either fused to, or admixed with G2Na. G2Nb did not induce RSV-B-reactive Ab responses. (iii) G2Na at low doses. Two injections of 3 µg G2Na in Alum were sufficient to induce protective immune responses in mouse lungs, preventing RSV-A and greatly reducing RSV-B infections. In cotton rats, G2Na-induced RSV-reactive Ab and protective immunity against RSV-A challenge that persisted for at least 24 weeks. (iv) injecting RSV primed mice with a single dose of G2Na/Alum or G2Na/PLGA [poly(D,L-lactide-co-glycolide]. Despite the presence of pre-existing RSV-specific Abs, these formulations effectively boosted anti-RSV Ab titres and increased Ab titres persisted for at least 21 weeks. Affinity maturation of these Abs increased from day 28 to day 148. These data indicate that G2Na has potential as a component of an RSV vaccine formulation.
Published: 2012
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7. New insights into childhood autoimmune hemolytic anemia: a French national observational study of 265 children

Author: Nathalie Aladjidi, Guy Leverger, Thierry Leblanc, Marie Quitterie Picat, Gérard Michel, Yves Bertrand, Brigitte Bader-Meunier, Alain Robert, Brigitte Nelken, Virginie Gandemer, Hélène Savel, Jean Louis Stephan, Fanny Fouyssac, Julien Jeanpetit, Caroline Thomas, Pierre Rohrlich, André Baruchel, Alain Fischer, Geneviève Chêne, and Y. Perel
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Background Autoimmune hemolytic anemia is a rare condition in children. Little is known about its initial presentation and the subsequent progression of the disease.Design and Methods Since 2004, a national observational study has been aiming to thoroughly describe cases and identify prognostic factors. Patients from all French hematologic pediatric units have been included if they had a hemoglobin concentration less than 11 g/dL, a positive direct antiglobulin test and hemolysis. Evans’ syndrome was defined by the association of autoimmune hemolytic anemia and immunological thrombocytopenic purpura. Data from patients’ medical records were registered from birth to last follow-up. Autoimmune hemolytic anemia was classified as primary or secondary. Remission criteria, qualifying the status of anemia at last follow-up, were used with the aim of identifying a subgroup with a favorable prognosis in continuous complete remission.Results The first 265 patients had a median age of 3.8 years at diagnosis. In 74% of cases the direct antiglobulin test was IgG/IgG+C3d. Consanguinity was reported in 8% of cases and first degree familial immunological diseases in 15% of cases. Evans’ syndrome was diagnosed in 37% of cases. Autoimmune hemolytic anemia was post-infectious in 10%, immunological in 53% and primary in 37% of cases. After a median follow-up of 3 years, 4% of children had died, 28% were still treatment-dependent and 39% were in continuous complete remission. In multivariate analysis, IgG and IgG+C3d direct antiglobulin tests were associated with a lower rate of survival with continuous complete remission (adjusted hazard ratio, 0.43; 95% confidence interval, 0.21–0.86).Conclusions This nationwide French cohort is the largest reported study of childhood autoimmune hemolytic anemia. The rarity of this condition is confirmed. Subgroups with genetic predisposition and underlying immune disorders were identified.
Published: 2011
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8. Rituximab therapy for childhood Evans syndrome

Author: Brigitte Bader-Meunier, Nathalie Aladjidi, Françoise Bellmann, Fabrice Monpoux, Brigitte Nelken, Alain Robert, Corinne Armari-Alla, Capucine Picard, Françoise Ledeist, Martine Munzer, Karima Yacouben, Yves Bertrand, Antoine Pariente, Arnaud Chaussé, Yves Perel, and Guy Leverger
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: The safety and efficacy of rituximab have been retrospectively assessed in 17 children with Evans syndrome. Patients received 4 or 3 weekly doses of rituximab (375 mg/m2 per dose) associated with prednisone, alone (14 patients) or associated with other immunosuppressive drugs. Complete or partial remission of at least one cytopenia was achieved in 13 out of the 17 patients (76%), and lasted in 11 of them with a mean follow-up of 2.4 years (range 0.5–7 years). Steroid therapy was stopped or tapered at 50–100% of the baseline dosage in all long-term responders. Moderate side effects and infection occurred only in 4 and 1 children respectively.
Published: 2007
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9. Understanding Barriers to Dental Care for Children with Special Health Care Needs

Author: Flores, Alain Robert
Subjects: Dentistry, Developmental Disabilities, Health Services Accessibility, Qualitative Research
Abstract: Purpose: The aim of this mixed method study was to identify barriers for children with special health care needs (SHCN) to receiving routine preventive dental care following dental care with general anesthesia (GA). Methods: Electronic health records were reviewed for inclusion criteria and demographic data. Caregivers of children with SHCN were contacted to participate in qualitative interviews. Interview topics explored child, family, and community level influences to accessing dental care. Qualitative analysis identified key themes of barriers and enablers to care.Results: A total of 1,708 children received dental care with GA during the two-year study period, of which 498 (29.16%) had a diagnosis of a SHCN. The most common type of SHCN was neurodevelopmental disorders (n=142, 28.51%). The mean age at time of GA was 8.6 years. Fifty caregivers completed interviews. Identified barriers to obtaining routine dental care included child stress/anxiety, finding an accepting provider, dismissive providers, and proximity of provider/transportation to dental care. Enablers to obtaining care included effective behavior management, continuity of provider/care, positive provider attitude, and referral to an accepting provider.Conclusion: Adequately trained and local providers with an accepting attitude are essential to enabling children with SHCN to obtain equitable access to routine preventive dental care.
Published: 2023

10. A locally administered single cycle influenza vaccine expressing a non-fusogenic stabilised haemagglutinin stimulates strong T-cell and neutralising antibody immunity

Author: Sadler, Holly, primary, Rijal, Pramila, additional, Tan, Tiong Kit, additional, and Townsend, Alain Robert, additional
Published: 2024
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11. Continued enteral nutrition until extubation compared with fasting before extubation in patients in the intensive care unit: an open-label, cluster-randomised, parallel-group, non-inferiority trial

Author: Mickaël Landais, Mai-Anh Nay, Johann Auchabie, Noemie Hubert, Aurélien Frerou, Aihem Yehia, Alain Mercat, Maud Jonas, Frédéric Martino, Mikael Moriconi, Anne Courte, Vincent Robert-Edan, Alexandre Conia, Florent Bavozet, Pierre-Yves Egreteau, Cédric Bruel, Anne Renault, Olivier Huet, Marc Feller, Nicolas Chudeau, Martine Ferrandiere, Anne Rebion, Alain Robert, Bruno Giraudeau, Jean Reignier, Arnaud W Thille, Elsa Tavernier, Stephan Ehrmann, Satar MORTAZA, Julien DEMISELLE, Taoufik SASSI, Charles DELALE, Julien GROUILLE, Anne DE TINTENIAC, Marie GESLAIN, Herve FLOCH, Pierre BAILLY, Laetitia BODENES, Gwenaël PRAT, Pierre KALFON, Gaetan BADRE, Cecile JOURDAIN, Thierry MAZZONI, Anthony LE MEUR, Pierre Marie FAYOLLE, Anne HERON, Odile MAILLET, Nelly LEDOUX, Amélie ROLLE, Régine RICHARD, Marc VALETTE, Marie-Ange AZAIS, Caroline POUPLET, Konstantinos BACHOUMAS, Jean Christophe CALLAHAN, Christophe GUITTON, Cedric DARREAU, Montaine LEFEVRE, Guillaume LELOUP, Mélanie BERTEL, Jerome DAUVERGNE, Laurence PACAUD, Karim LAKHAL, Maelle MARTIN, Charlotte GARRET, Jean-Baptiste LASCARROU, Thierry BOULAIN, Armelle MATHONNET, Grégoire MULLER, François PHILIPPART, Marc TRAN, Julien FOURNIER, Jean-Pierre FRAT, Remi COUDROY, Delphine CHATELLIER, Guillaume HALLEY, Arnaud GACOUIN, Jerome HOFF, Servane VASTAL, Anne-Charlotte TELLIER, Mathilde BARBAZ, Charlotte SALMON GANDONNIERE, Emmanuelle MERCIER, and Walid DARWICHE
Subjects: Pulmonary and Respiratory Medicine
Published: 2023

12. The Effect of an Accelerated Renal Replacement Therapy Initiation Is Not Modified by Baseline Risk

Author: Federico Angriman, Bruno L. Ferreyro, Natalia Angeloni, Bruno R. da Costa, Ron Wald, Sean M. Bagshaw, Neill K.J. Adhikari, Rinaldo Bellomo, Didier Dreyfuss, Bin Du, Martin P. Gallagher, Stéphane Gaudry, François Lamontagne, Michael Joannidis, Kathleen D. Liu, Daniel F. McAuley, Shay P. McGuinness, Alistair D. Nichol, Marlies Ostermann, Paul M. Palevsky, Haibo Qiu, Ville Pettilä, Antoine G. Schneider, Orla M. Smith, Suvi T. Vaara, Matthew Weir, Glenn M. Eastwood, Leah Peck, Helen Young, Peter Kruger, Gordon Laurie, Emma Saylor, Jason Meyer, Ellen Venz, Krista Wetzig, Craig French, Forbes McGain, John Mulder, Gerard Fennessy, Sathyajith Koottayi, Samantha Bates, Miriam Towns, Rebecca Morgan, Anna Tippett, Andrew Udy, Chris Mason, Elisa Licari, Dashiell Gantner, Jason McClure, Alistair Nichol, Phoebe McCracken, Jasmin Board, Emma Martin, Shirley Vallance, Meredith Young, Chelsey Vladic, Steve McGloughlin, David Gattas, Heidi Buhr, Jennifer Coles, Debra Hutch, James Wun, Louise Cole, Christina Whitehead, Julie Lowrey, Kristy Masters, Rebecca Gresham, Victoria Campbell, David Gutierrez, Jane Brailsford, Loretta Forbes, Lauren Murray, Teena Maguire, Martina NiChonghaile, Neil Orford, Allison Bone, Tania Elderkin, Tania Salerno, Tim Chimunda, Jason Fletcher, Emma Broadfield, Sanjay Porwal, Cameron Knott, Catherine Boschert, Julie Smith, Angus Richardson, Dianne Hill, Graeme Duke, Peter Oziemski, Santiago Cegarra, Peter Chan, Deborah Welsh, Stephanie Hunter, Owen Roodenburg, John Dyett, Nicos Kokotsis, Max Moser, Yang Yang, Laven Padayachee, Joseph Vetro, Himangsu Gangopadhyay, Melissa Kaufman, Angaj Ghosh, Simone Said, Alpesh Patel, Shailesh Bihari, Elisha Matheson, Xia Jin, Tapaswi Shrestha, Kate Schwartz, Rosalba Cross, Winston Cheung, Helen Wong, Mark Kol, Asim Shah, Amanda Y. Wang, Zoltan Endre, Celia Bradford, Pierre Janin, Simon Finfer, Naomi Diel, Jonathan Gatward, Naomi Hammond, Anthony Delaney, Frances Bass, Elizabeth Yarad, Hergen Buscher, Claire Reynolds, Nerilee Baker, Romuald Bellmann, Andreas Peer, Julia Hasslacher, Paul Koglberger, Sebastian Klein, Klemens Zotter, Anna Brandtner, Armin Finkenstedt, Adelheid Ditlbacher, Frank Hartig, Dietmar Fries, Mirjam Bachler, Bettina Schenk, Martin Wagner, Philipp Eller, Thomas Staudinger, Esther Tiller, Peter Schellongowski, Andja Bojic, Eric A. Hoste, Stephanie Bracke, Luc De Crop, Daisy Vermeiren, Fernando Thome, Bianca Chiella, Lucia Fendt, Veronica Antunes, Frédérick D'Aragon, Charles St-Arnaud, Michael Mayette, Élaine Carbonnaeu, Joannie Marchand, Marie-Hélène Masse, Marilène Ladouceur, Alexis F. Turgeon, François Lauzier, David Bellemare, Charles Langis Francoeur, Guillaume LeBlanc, Gabrielle Guilbault, Stéphanie Grenier, Eve Cloutier, Annick Boivin, Charles Delisle-Thibault, Panagiota Giannakouros, Olivier Costerousse, Jean-François Cailhier, François-Martin Carrier, Ali Ghamraoui, Martine Lebrasseur, Fatna Benettaib, Maya Salamé, Dounia Boumahni, Ying Tung Sia, Jean-François Naud, Isabelle Roy, Henry T. Stelfox, Stacey Ruddell, Braden J. Manns, Shelley Duggan, Dominic Carney, Jennifer Barchard, Richard P. Whitlock, Emilie Belley-Cote, Nevena Savija, Alexandra Sabev, Troy Campbell, Thais Creary, Kelson Devereaux, Shira Brodutch, Claudio Rigatto, Bojan Paunovic, Owen Mooney, Anna Glybina, Oksana Harasemiw, Michelle Di Nella, John Harmon, Navdeep Mehta, Louis Lakatos, Nicole Haslam, Francois Lellouche, Mathieu Simon, Ying Tung, Patricia Lizotte, Pierre-Alexandre Bourchard, Bram Rochwerg, Tim Karachi, Tina Millen, John Muscedere, David Maslove, J. Gordon Boyd, Stephanie Sibley, John Drover, Miranda Hunt, Ilinca Georgescu, Randy Wax, Ilan Lenga, Kavita Sridhar, Andrew Steele, Kelly Fusco, Taneera Ghate, Michael Tolibas, Holly Robinson, Matthew A. Weir, Ravi Taneja, Ian M. Ball, Amit Garg, Eileen Campbell, Athena Ovsenek, Sean van Diepen, Nadia Baig, Sheldon Magder, Han Yao, Ahsan Alam, Josie Campisi, Erika MacIntyre, Ella Rokosh, Kimberly Scherr, Stephen Lapinsky, Sangeeta Mehta, Sumesh Shah, Daniel J. Niven, Michael Russell, Kym Jim, Gillian Brown, Kerry Oxtoby, Adam Hall, Luc Benoit, Colleen Sokolowski, Bhanu Prasad, Jag Rao, Shelley Giebel, Demetrios J. Kutsogiannis, Patricia Thompson, Tayne Thompson, Robert Cirone, Kanthi Kavikondala, Mark Soth, France Clarke, Alyson Takaoka, David Mazer, Karen Burns, Jan Friedrich, David Klein, Gyan Sandhu, Marlene Santos, Imrana Khalid, Jennifer Hodder, Peter Dodek, Najib Ayas, Victoria Alcuaz, Gabriel Suen, Oleksa Rewa, Gurmeet Singh, Sean Norris, Neil Gibson, Castro Arias, Aysha Shami, Celine Pelletier, Alireza Zahirieh, Andre Amaral, Nicole Marinoff, Navjot Kaur, Adic Perez, Jane Wang, Gregory Haljan, Christopher Condin, Lauralyn McIntyre, Brigette Gomes, Rebecca Porteous, Irene Watpool, Swapnil Hiremath, Edward Clark, Margaret S. Herridge, Felicity Backhouse, M. Elizabeth Wilcox, Karolina Walczak, Vincent Ki, Asheer Sharman, Martin Romano, R.T. Noel Gibney, Adam S. Romanovsky, Lorena McCoshen, Gordon Wood, Daniel Ovakim, Fiona Auld, Gayle Carney, Meili Duan, Xiaojun Ji, Dongchen Guo, Zhili Qi, Jin Lin, Meng Zhang, Lei Dong, Jingfeng Liu, Pei Liu, Deyuan Zhi, Guoqiang Bai, Yu Qiu, Ziqi Yang, Jing Bai, Zhuang Liu, Haizhou Zhuang, Haiman Wang, Jian Li, Mengya Zhao, Xiao Zhou, Xianqing Shi, Baning Ye, Manli Liu, Jing Wu, Yongjian Fu, Dali Long, Yu Pan, Jinlong Wang, Huaxian Mei, Songsong Zhang, Mingxiang Wen, Enyu Yang, Sijie Mu, Jianquan Li, Tingting Hu, Bingyu Qin, Min Li, Cunzhen Wang, Xin Dong, Kaiwu Wang, Haibo Wang, Jianxu Yang, Chuanyao Wang, Dongxin Wang, Nan Li, Zhui Yu, Song Xu, Lan Yao, Guo Hou, Zhou Liu, Liping Lu, Yingtao Lian, Chunting Wang, Jichen Zhang, Ruiqi Ding, Guoqing Qi, Qizhi Wang, Peng Wang, Zhaoli Meng, Man Chen, Xiaobo Hu, Xiandi He, Shibing Zhao, Lele Hang, Rui Li, Suhui Qin, Kun Lu, Shijuan Dun, Cheng Liu, Qi Zhou, Zhenzhen Chen, Jing Mei, Minwei Zhang, Hao Xu, Jincan Lin, Qindong Shi, Lijuan Fu, Qinjing Zeng, Hongye Ma, Jinqi Yan, Lan Gao, Hongjuan Liu, Lei Zhang, Hao Li, Xiaona He, Jingqun Fan, Litao Guo, Yu Liu, Xue Wang, Jingjing Sun, Zhongmin Liu, Juan Yang, Lili Ding, Lulu Sheng, Xingang Liu, Jie Yan, Quihui Wang, Yifeng Wang, Dan Zhao, Shuangping Zhao, Chenghuan Hu, Jing Li, Fuxing Deng, Haibo Qui, Yi Yang, Min Mo, Chun Pan, Changde Wu, Yingzi Huang, Lili Huang, Airan Liu, Anna-Maija Korhonen, Sanna Törnblom, Sari Sutinen, Leena Pettilä, Jonna Heinonen, Eliria Lappi, Taria Suhonen, Sari Karlsson, Sanna Hoppu, Ville Jalkanen, Anne Kuitunen, Markus Levoranta, Jaakko Långsjö, Sanna Ristimäki, Kaisa Malila, Anna Wootten, Simo Varila, Mikko J Järvisalo, Outi Inkinen, Satu Kentala, Keijo Leivo, Paivi Haltia, Jean-Damien Ricard, Jonathan Messika, Abirami Tiagarajah, Malo Emery, Aline Dechanet, Coralie Gernez, Damien Roux, Laurent Martin-Lefevre, Maud Fiancette, Isabelle Vinatier, Jean Claude Lacherade, Gwenhaël Colin, Christine Lebert, Marie-Ange Azais, Aihem Yehia, Caroline Pouplet, Matthieu Henry- Lagarrigue, Amélie Seguin, Laura Crosby, Julien Maizel, Dimitri Titeca-Beauport, Alain Combes, Ania Nieszkowska, Paul Masi, Alexandre Demoule, Julien Mayaux, Martin Dres, Elise Morawiec, Maxens Decalvele, Suela Demiri, Morgane Faure, Clémence Marios, Maxime Mallet, Marie Amélie Ordon, Laura Morizot, Marie Cantien, François Pousset, Florent Poirson, Yves Cohen, Laurent Argaud, Martin Cour, Laurent Bitker, Marie Simon, Romain Hernu, Thomas Baudry, Sylvie De La Salle, Adrien Robine, Nicholas Sedillot, Xavier Tchenio, Camille Bouisse, Sylvie Roux, Fabienne Tamion, Steven Grangé, Dorothée Carpentier, Guillaume Chevrel, Luis Ensenyat-Martin, Sophie Marque, Jean-Pierre Quenot, Pascal Andreu, Auguste Dargent, Audrey Large, Nicolas Chudeau, Mickael Landais, Benoit Derrien, Jean Christophe Callahan, Christophe Guitton, Charlène Le Moal, Alain Robert, Karim Asehnoune, Raphaël Cinotti, Nicolas Grillot, Dominique Demeure, Christophe Vinsonneau, Imen Rahmani, Mehdi Marzouk, Thibault Dekeyser, Caroline Sejourne, Mélanie Verlay, Fabienne Thevenin, Lucie Delecolle, Didier Thevenin, Bertrand Souweine, Elisabeth Coupez, Mireille Adda, Jean-Pierre Eraldi, Antoine Marchalot, Nicolas De Prost, Armand Mekontso Dessap, Keyvan Razazi, Ferhat Meziani, Julie Boisrame-Helms, Raphael Clere-Jehl, Xavier Delabranche, Christine Kummerlen, Hamid Merdji, Alexandra Monnier, Yannick Rabouel, Hassene Rahmani, Hayat Allam, Samir Chenaf, Vincenta Franja, Bertrand Pons, Michel Carles, Frédéric Martino, Régine Richard, Benjamin Zuber, Guillaume Lacave, Karim Lakhal, Bertrand Rozec, Hoa Dang Van, Éric Boulet, Fouad Fadel, Cedric Cleophax, Nicolas Dufour, Caroline Grant, Marie Thuong, Jean Reignier, Emmanuel Canet, Laurent Nicolet, Thierry Boulain, Mai-Anh Nay, Dalila Benzekri, François Barbier, Anne Bretagnol, Toufik Kamel, Armelle Mathonnet, Grégoire Muller, Marie Skarzynski, Julie Rossi, Amandine Pradet, Sandra Dos Santos, Aurore Guery, Lucie Muller, Luis Felix, Julien Bohé, Guillaume Thiéry, Nadia Aissaoui, Damien Vimpere, Morgane Commeureuc, Jean-Luc Diehl, Emmanuel Guerot, Orfeas Liangos, Monika Wittig, Alexander Zarbock, Mira Küllmar, Thomas van Waegeningh, Nadine Rosenow, Kathy Brickell, Peter Doran, Patrick T. Murray, Giovanni Landoni, Rosalba Lembo, Alberto Zangrillo, Giacomo Monti, Margherita Tozzi, Matteo Marzaroli, Gaetano Lombardi, Gianluca Paternoster, Michelangelo Vitiello, Shay McGuinness, Rachael Parke, Magdalena Butler, Eileen Gilder, Keri-Anne Cowdrey, Samantha Wallace, Jane Hallion, Melissa Woolett, Philippa Neal, Karina Duffy, Stephanie Long, Colin McArthur, Catherine Simmonds, Yan Chen, Rachael McConnochie, Lynette Newby, David Knight, Seton Henderson, Jan Mehrtens, Stacey Morgan, Anna Morris, Kymbalee Vander Hayden, Tara Burke, Matthew Bailey, Ross Freebairn, Lesley Chadwick, Penelope Park, Christine Rolls, Liz Thomas, Ulrike Buehner, Erin Williams, Jonathan Albrett, Simon Kirkham, Carolyn Jackson, Troy Browne, Jennifer Goodson, David Jackson, James Houghton, Owen Callender, Vicki Higson, Owen Keet, Clive Dominy, Paul Young, Anna Hunt, Harriet Judd, Cassie Lawrence, Shaanti Olatunji, Yvonne Robertson, Charlotte Latimer-Bell, Deborah Hendry, Agnes Mckay-Vucago, Nina Beehre, Eden Lesona, Leanlove Navarra, Chelsea Robinson, Ryan Jang, Andrea Junge, Bridget Lambert, Michel Thibault, Philippe Eckert, Sébastien Kissling, Erietta Polychronopoulos, Elettra Poli, Marco Altarelli, Madeleine Schnorf, Samia Abed Mallaird, Claudia Heidegger, Aurelie Perret, Philippe Montillier, Frederic Sangla, Seigenthaller Neils, Aude De Watteville, Mandeep-Kaur Phull, Aparna George, Nauman Hussain, Tatiana Pogreban, Steve Lobaz, Alison Daniels, Mishell Cunningham, Deborah Kerr, Alice Nicholson, Pradeep Shanmugasundaram, Judith Abrams, Katarina Manso, Geraldine Hambrook, Elizabeth McKerrow, Juvy Salva, Stephen Foulkes, Matthew Wise, Matt Morgan, Jenny Brooks, Jade Cole, Tracy Michelle Davies, Helen Hill, Emma Thomas, Marcela Vizcaychipi, Behrad Baharlo, Jaime Carungcong, Patricia Costa, Laura Martins, Ritoo Kapoor, Tracy Hazelton, Angela Moon, Janine Musselwhite, Ben Shelley, Philip McCall, Gill Arbane, Aneta Bociek, Martina Marotti, Rosario Lim, Sara Campos, Neus Grau Novellas, Armando Cennamo, Andrew Slack, Duncan Wyncoll, Luigi Camporota, Simon Sparkes, Rosalinde Tilley, Austin Rattray, Gayle Moreland, Jane Duffy, Elizabeth McGonigal, Philip Hopkins, Clare Finney, John Smith, Harriet Noble, Hayley Watson, Claire-Louise Harris, Emma Clarey, Eleanor Corcoran, James Beck, Clare Howcroft, Nora Youngs, Elizabeth Wilby, Bethan Ogg, Adam Wolverson, Sandra Lee, Susie Butler, Maryanne Okubanjo, Julia Hindle, Ingeborg Welters, Karen Williams, Emily Johnson, Julie Patrick-Heselton, David Shaw, Victoria Waugh, Richard Stewart, Esther Mwaura, Lynn Wren, Louise Mew, Sara-Beth Sutherland, Jane Adderley, Jim Ruddy, Margaret Harkins, Callum Kaye, Teresa Scott, Wendy Mitchell, Felicity Anderson, Fiona Willox, Vijay Jagannathan, Michele Clark, Sarah Purv, Andrew Sharman, Megan Meredith, Lucy Ryan, Louise Conner, Cecilia Peters, Dan Harvey, Ashraf Roshdy, Amy Collins, Malcolm Sim, Steven Henderson, Nigel Chee, Sally Pitts, Katie Bowman, Maria Dilawershah, Luke Vamplew, Elizabeth Howe, Paula Rogers, Clara Hernandez, Clara Prendergast, Jane Benton, Alex Rosenberg, Lui G. Forni, Alice Grant, Paula Carvelli, Ajay Raithatha, Sarah Bird, Max Richardson, Matthew Needham, Claire Hirst, Jonathan Ball, Susannah Leaver, Luisa Howlett, Carlos Castro Delgado, Sarah Farnell-Ward, Helen Farrah, Geraldine Gray, Gipsy Joseph, Francesca Robinson, Ascanio Tridente, Clare Harrop, Karen Shuker, Derek McLaughlan, Judith Ramsey, Sharon Meehan, Bernd Oliver Rose, Rosie Reece-Anthony, Babita Gurung, Tony Whitehouse, Catherine Snelson, Tonny Veenith, Andy Johnston, Lauren Cooper, Ron Carrera, Karen Ellis, Emma Fellows, Samanth Harkett, Colin Bergin, Elaine Spruce, Liesl Despy, Stephanie Goundry, Natalie Dooley, Tracy Mason, Amy Clark, Gemma Dignam, Geraldine Ward, Ben Attwood, Penny Parsons, Sophie Mason, Michael Margarson, Jenny Lord, Philip McGlone, Luke E. Hodgson, Indra Chadbourn, Raquel Gomez, Jordi Margalef, Rinus Pretorius, Alexandra Hamshere, Joseph Carter, Hazel Cahill, Lia Grainger, Kate Howard, Greg Forshaw, Zoe Guy, Kianoush B. Kashani, Robert C. Albright, Amy Amsbaugh, Anita Stoltenberg, Alexander S. Niven, Matthew Lynch, AnnMarie O'Mara, Syed Naeem, Sairah Sharif, Joyce McKenney Goulart, Ashita Tolwani, Claretha Lyas, Laura Latta, Azra Bihorac, Haleh Hashemighouchani, Philip Efron, Matthew Ruppert, Julie Cupka, Sean Kiley, Joshua Carson, Peggy White, George Omalay, Sherry Brown, Laura Velez, Alina Marceron, Javier A. Neyra, Juan Carlos Aycinena, Madona Elias, Victor M. Ortiz-Soriano, Caroline Hauschild, and Robert Dorfman
Subjects: Renal Replacement Therapy, Pulmonary and Respiratory Medicine, Critical Illness, Medicine and Health Sciences, Humans, Acute Kidney Injury
Published: 2022

13. Table S1, Table S2, Table S3, Table S4, Figure S1Figure S2, Figure S3, Figure S4, Figure S5, Figure S6, Figure S7 from Efficacy of the Antibody–Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors

Author: Nathalie Corvaia, Eric Chetaille, Mariya Pavlyuk, Cyrille Dreyfus, Michel Perez, Alain Beck, Jean-Francois Haeuw, Thierry Champion, Nicolas Boute, Martine Malissard, Charlotte Beau-Larvor, Alain Robert, Noureddine Loukili, Matthieu Broussas, and Barbara Akla
Abstract: Table S1 shows expression of IGF1R on human tissues Table S2 shows expression of IGF1R on Tumor and Normal cells Table S3 shows DAR calculation Table S4 shows impact of W0101 on cell cycle Figure S1 shows the flowchart for selection of m208F2 Figure S2 shows kinetics of internalization of murine anti-IGF1R antibodies Figure S3 shows inhibition of binding and phosphorylation of IGF-1R Figure S4 shows binding and internalisation of W0101 on MCF7 cells Figure S5 shows impact of W0101 on apoptose compared to MMAE and isotype control ADC Figure S6 shows in vivo activity of naked antibody on MCF7 and NCI-H2122 models Figure S7 demonstrated the absence of bystander effect of W0101
Published: 2023

14. Data from Efficacy of the Antibody–Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors

Author: Nathalie Corvaia, Eric Chetaille, Mariya Pavlyuk, Cyrille Dreyfus, Michel Perez, Alain Beck, Jean-Francois Haeuw, Thierry Champion, Nicolas Boute, Martine Malissard, Charlotte Beau-Larvor, Alain Robert, Noureddine Loukili, Matthieu Broussas, and Barbara Akla
Abstract: The insulin-like growth factor type 1 receptor (IGF-1R) is important in tumorigenesis, and its overexpression occurs in numerous tumor tissues. To date, therapeutic approaches based on mAbs and tyrosine kinase inhibitors targeting IGF-1R have only shown clinical benefit in specific patient populations. We report a unique IGF-1R–targeted antibody–drug conjugate (ADC), W0101, designed to deliver a highly potent cytotoxic auristatin derivative selectively to IGF-1R overexpressing tumor cells. The mAb (hz208F2-4) used to prepare the ADC was selected for its specific binding properties to IGF-1R compared with the insulin receptor, and for its internalization properties. Conjugation of a novel auristatin derivative drug linker to hz208F2-4 did not alter its binding and internalization properties. W0101 induced receptor-dependent cell cytotoxicity in vitro when applied to various cell lines overexpressing IGF-1R, but it did not affect normal cells. Efficacy studies were conducted in several mouse models expressing different levels of IGF-1R to determine the sensitivity of the tumors to W0101. W0101 induced potent tumor regression in certain mouse models. Interestingly, the potency of W0101 correlated with the expression level of IGF-1R evaluated by IHC. In an MCF-7 breast cancer model with high-level IGF-1R expression, a single injection of W0101 3 mg/kg led to strong inhibition of tumor growth. W0101 provides a potential new therapeutic option for patients overexpressing IGF-1R. A first-in-human trial of W0101 is currently ongoing to address clinical safety.
Published: 2023

15. Les avatars d’un bois gravé (l’auteur écrivant, 1490-1850)

Author: Alain Robert
Published: 2021

16. Potential gross and net N2O production by the gut of different termite species are related to the abundance of nitrifier and denitrifier groups

Author: Edouard Miambi, Thi My Dung Jusselme, Charline Creuzé des Châtelliers, Alain Robert, Abigail Delort, and Xavier Le Roux
Abstract: Termites can be a significant source of N2O emissions in tropical and subtropical ecosystems. The emission rates vary greatly between species, with many species creating emission hotspots while others acting as net sinks. We studied the relationships between net and gross N2O production/consumption and the abundances of eight nitrifier and denitrifier groups (as determined by functional marker genes) in termite gut homogenates for eleven species from five feeding guilds. Overall, the abundance of nitrite reducers and, to a lesser extent, nitrifiers in the gut was strongly correlated with gross N2O production, whereas N2O reduction was correlated with the abundance of nosZ1 N2O reducers and the nosZ1/nirK ratio. Our results show that the differences in gross and net N2O production rates between termite species are primarily due to differences in nitrifier and denitrifier abundances, as well as the ratio of related functional gene marker abundances in the guts. N2O production rates were negatively correlated to the ratio of nosZ to nir. N2O production rates by live individuals measured for a subset of termite species were lower in the wood-feeding than in other species. Our results suggest that the differences in functional gene abundances may be associated with feeding guild, although this should be tested on a larger number of termite species.
Published: 2022

17. Result of the MICROSCOPE weak equivalence principle test

Author: Pierre Touboul, Gilles Métris, Manuel Rodrigues, Joel Bergé, Alain Robert, Quentin Baghi, Yves André, Judicael Bedouet, Damien Boulanger, Stefanie Bremer, Patrice Carle, Ratana Chhun, Bruno Christophe, Valerio Cipolla, Thibault Damour, Pascale Danto, Louis Demange, Hansjoerg Dittus, Océane Dhuicque, Pierre Fayet, Bernard Foulon, Pierre-Yves Guidotti, Daniel Hagedorn, Emilie Hardy, Phuong-Anh Huynh, Patrick Kayser, Stephanie Lala, Claus Lämmerzahl, Vincent Lebat, Françoise Liorzou, Meike List, Frank Löffler, Isabelle Panet, Martin Pernot-Borràs, Laurent Perraud, Sandrine Pires, Benjamin Pouilloux, Pascal Prieur, Alexandre Rebray, Serge Reynaud, Benny Rievers, Hanns Selig, Laura Serron, Timothy Sumner, Nicolas Tanguy, Patrizia Torresi, Pieter Visser, ONERA, Université Paris Saclay [Palaiseau], ONERA-Université Paris-Saclay, Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), DPHY, ONERA, Université Paris Saclay [Châtillon], Centre National d'Études Spatiales [Toulouse] (CNES), ONERA, Université Paris Saclay [Châtillon], ONERA / DTIS, Université de Toulouse [Toulouse], ONERA-PRES Université de Toulouse, DLR Institute of Space Systems, German Aerospace Center (DLR), Institut des Hautes Études Scientifiques (IHES), IHES, Laboratoire de physique de l'ENS - ENS Paris (LPENS), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Centre de Physique Théorique [Palaiseau] (CPHT), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), DTIS, ONERA, Université Paris Saclay [Palaiseau], Institut de Physique du Globe de Paris (IPGP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS), École nationale des sciences géographiques (ENSG), Institut National de l'Information Géographique et Forestière [IGN] (IGN)-Université Gustave Eiffel, Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Kastler Brossel (LKB [Collège de France]), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: High Energy Physics - Theory, analyse de données, Physics and Astronomy (miscellaneous), equivalence principle: validity test, satellite, Relativité générale, FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), space mission, General Relativity and Quantum Cosmology, principe d'équivalence, [SPI]Engineering Sciences [physics], experimental gravitation, general relativity, stochastic, platinum, Instrumentation and Methods for Astrophysics (astro-ph.IM), MICROSCOPE, [PHYS]Physics [physics], Eötvös parameter, acceleration, gravitation expérimentale, space accelerometers, error: statistical, paramètre d'Eovos, High Energy Physics - Theory (hep-th), equivalence principle, gravitation, mission spatiale, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], Astrophysics - Instrumentation and Methods for Astrophysics, titanium: alloy
Abstract: The space mission MICROSCOPE dedicated to the test of the Equivalence Principle (EP) operated from April 25, 2016 until the deactivation of the satellite on October 16, 2018. In this analysis we compare the free-fall accelerations ($a_{\rm A}$ and $a_{\rm B}$) of two test masses in terms of the E\"otv\"os parameter $\eta({\rm{A, B}}) = 2 \frac{a_{\rm A}- a_{\rm B}}{a_{\rm A}+ a_{\rm B}}$. No EP violation has been detected for two test masses, made from platinum and titanium alloys, in a sequence of 19 segments lasting from 13 to 198 hours down to the limit of the statistical error which is smaller than $10^{-14}$ for $ \eta({\rm{Ti, Pt}})$. Accumulating data from all segments leads to $\eta({\rm{Ti, Pt}}) =[-1.5\pm{}2.3{\rm (stat)}\pm{}1.5{\rm (syst)}] \times{}10^{-15}$ showing no EP violation at the level of $2.7\times{}10^{-15}$ if we combine stochastic and systematic errors quadratically. This represents an improvement of almost two orders of magnitude with respect to the previous best such test performed by the E\"ot-Wash group. The reliability of this limit has been verified by comparing the free falls of two test masses of the same composition (platinum) leading to a null E\"otv\"os parameter with a statistical uncertainty of $1.1\times{}10^{-15}$., Comment: Class. Quantum Grav. 39 204009
Published: 2022

18. The MICROSCOPE space mission to test the Equivalence Principle

Author: Gilles Métris, Pierre Touboul, Manuel Rodrigues, Yves André, and Alain Robert
Subjects: Physics, Microscope, 010504 meteorology & atmospheric sciences, law, 0103 physical sciences, Mathematical analysis, General Physics and Astronomy, 010306 general physics, Space (mathematics), 01 natural sciences, 0105 earth and related environmental sciences, law.invention, Test (assessment)
Published: 2020

19. Courtship Behavior Confusion in Two Subterranean Termite Species that Evolved in Allopatry (Blattodea, Rhinotermitidae, Coptotermes)

Author: Thomas Chouvenc, David Sillam-Dussès, and Alain Robert
Subjects: Male, Sympatry, Zoology, Isoptera, Polyenes, Biochemistry, Sexual Behavior, Animal, Coptotermes, Coptotermes gestroi, Animals, Sex Attractants, Mating, Ecology, Evolution, Behavior and Systematics, biology, Courtship, General Medicine, Reproductive isolation, biology.organism_classification, Biological Evolution, Florida, Biological dispersal, Female, Seasons, Introduced Species, Animal Distribution, Formosan subterranean termite, Rhinotermitidae
Abstract: Congeneric species that live in sympatry may have evolved various mechanisms that maintain reproductive isolation among species. However, with the spread of invasive organisms owing to increased global human activity, some species that evolved in allopatry can now be found outside their native range and may have the opportunity to interact, in the absence of mechanisms for reproductive isolation. In South Florida, where the Asian subterranean termite, Coptotermes gestroi (Wamann), and the Formosan subterranean termite, Coptotermes formosanus Shiraki (Blattodea: Rhinotermitidae) are invasive, the two species can engage in heterospecific mating behavior as their distribution range and their dispersal flight season both overlap. Termites rely on semiochemicals for many of their activities, including finding a mate after a dispersal flight. In this study, we showed that females of both species produce (3Z,6Z,8E)-dodeca-3,6,8-trien-1-ol (DTE) from their tergal glands as a shared sex pheromone. We suggest that both species primarily rely on an inundative dispersal flight strategy to find a mate, and that DTE is used as a short distance pheromone or contact pheromone to initiate and maintain the tandem between males and females. The preference of C. gestroi males for C. formosanus females during tandem resulted from the relatively high amount of DTE produced by tergal glands of C. formosanus females, when compared with those of C. gestroi females. This results in confusion of mating in the field during simultaneous dispersal flights, with a potential for hybridization. Such observations imply that no prezygotic barriers emerged while the two species evolved in allopatry for ~18 Ma.
Published: 2020

20. Decrease in serum testosterone levels after short-term occupational exposure to diisononyl phthalate in male workers

Author: Mathieu Dziurla, Alain Robert, Jean-Bernard Henrotin, Georges Weryha, Manuela Burgart, Fanny Jeandel, Anne-Marie Lambert-Xolin, and Eva Feigerlova
Subjects: Adult, Male, medicine.medical_specialty, Urinary system, Phthalic Acids, 010501 environmental sciences, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, N-terminal telopeptide, Occupational Exposure, Internal medicine, Androgen deficiency, medicine, Humans, Industry, Testosterone, Longitudinal Studies, 030304 developmental biology, 0105 earth and related environmental sciences, 0303 health sciences, Diisononyl phthalate, business.industry, Public Health, Environmental and Occupational Health, Phthalate, Testosterone (patch), Middle Aged, medicine.disease, Endocrinology, Erectile dysfunction, chemistry, Linear Models, France, business, Plastics, Biomarkers, Environmental Monitoring, Hormone
Abstract: ObjectiveThe objective of the study was to examine the effects of occupational exposure to diisononyl phthalate (DINP) on serum testosterone levels in male workers.MethodsFrom 2015 to 2018, 97 male workers were recruited from six French factories in the plastics industry. In a short longitudinal study, changes over 3 days in the level of total or free serum testosterone and DINP exposure were measured. DINP exposure was measured by urinary biomonitoring: mono-4-methyl-7-oxo-octyl phthalate (OXO-MINP), mono-4-methyl-7-hydroxy-octyl phthalate (OH-MINP) and mono-4-methyl-7-carboxyheptylphthalate (CX-MINP). We further analysed changes in follicle-stimulating hormone, luteinising hormone, total testosterone to oestradiol ratio and two bone turnover markers (procollagen-type-I-N propeptide, C terminal cross-linking telopeptide of type I collagen), and erectile dysfunction via standardised questionnaires (International Index of Erectile Function, Androgen Deficiency in Aging Males). Linear mixed models were used with the variables ‘age’ and ‘abdominal diameter’ included as confounder.ResultsIncreased urinary OXO-MINP was associated with a significant decrease in total serum testosterone concentrations, but only for workers who exhibited the smallest variations and lowest exposures (p=0.002). The same pattern was observed for CX-MINP but was not significant; no association with OH-MINP was detectable. More self-reported erectile problems were found in workers exposed directly to DINP at the workstation (p=0.01). No changes were observed for the other biological parameters.ConclusionsShort-term exposure to DINP is associated with a decrease in total serum testosterone levels in male workers. Our results suggest that DINP could present weak antiandrogenic properties in humans, but these need to be confirmed by other studies.
Published: 2020

21. New Multichannel Ethernet Protocol for Passive Optical Star Local Area Networks Using Coherent Transmission.

Author: Daniel Rodellar, Cristian Bungarzeanu, Hector Garcia, Caroline Brisson, Alain Küng, and Philippe-Alain Robert
Published: 1998
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22. Lifespan prolonging mechanisms and insulin upregulation without fat accumulation in long-lived reproductives of a higher termite

Author: Roland Lupoli, Erich Bornberg-Bauer, Hei Sook Sul, Mark C Harrison, Sarah Séité, Jose A. Viscarra, Z. Wilhelm de Beer, Mireille Vasseur-Cognet, David Sillam-Dussès, Arnaud Lemainque, Tom J. M. Van Dooren, Sébastien Acket, Alain Robert, Laure-Anne Poissonnier, David Renault, Muriel Andrieu, Institut d'écologie et des sciences de l'environnement de Paris (iEES), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Recherche Agronomique (INRA), Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris ), Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Laboratoire d'Ethologie Expérimentale et Comparée (LEEC), Université Sorbonne Paris Nord, Naturalis Biodiversity Center [Leiden], University of Pretoria [South Africa], Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Génie Enzymatique et Cellulaire. Reconnaissance Moléculaire et Catalyse - UMR CNRS 7025 (GEC UPJV), Université de Technologie de Compiègne (UTC)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), University of California (UC), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Ethologie expérimentale et comparée (EEC), Centre National de la Recherche Scientifique (CNRS)-Université Sorbonne Paris Nord, Plateforme Cytométrie et Immunobiologie [Institut Cochin] (CYBIO), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), HAL-SU, Gestionnaire, and Van Dooren, Tom
Subjects: Aging, DNA Repair, QH301-705.5, medicine.medical_treatment, Longevity, education, Medicine (miscellaneous), Isoptera, Biology, Oogenesis, Article, General Biochemistry, Genetics and Molecular Biology, Transcriptome, 03 medical and health sciences, Metabolomics, 0302 clinical medicine, Downregulation and upregulation, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Gene expression, Hemolymph, medicine, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Animals, Insulin, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Biology (General), 030304 developmental biology, [SDV.EE]Life Sciences [q-bio]/Ecology, environment, 0303 health sciences, Reproduction, Eusociality, Up-Regulation, Cell biology, [SDE.BE] Environmental Sciences/Biodiversity and Ecology, [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, [SDV.EE] Life Sciences [q-bio]/Ecology, environment, Ageing, Fertility, Metabolism, [SDV.BA.ZI] Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDE.BE]Environmental Sciences/Biodiversity and Ecology, General Agricultural and Biological Sciences, 030217 neurology & neurosurgery
Abstract: Kings and queens of eusocial termites can live for decades, while queens sustain a nearly maximal fertility. To investigate the molecular mechanisms underlying their long lifespan, we carried out transcriptomics, lipidomics and metabolomics in Macrotermes natalensis on sterile short-lived workers, long-lived kings and five stages spanning twenty years of adult queen maturation. Reproductives share gene expression differences from workers in agreement with a reduction of several aging-related processes, involving upregulation of DNA damage repair and mitochondrial functions. Anti-oxidant gene expression is downregulated, while peroxidability of membranes in queens decreases. Against expectations, we observed an upregulated gene expression in fat bodies of reproductives of several components of the IIS pathway, including an insulin-like peptide, Ilp9. This pattern does not lead to deleterious fat storage in physogastric queens, while simple sugars dominate in their hemolymph and large amounts of resources are allocated towards oogenesis. Our findings support the notion that all processes causing aging need to be addressed simultaneously in order to prevent it., Séité, Harrison, et al. investigate the mechanisms underlying long lifespan in queens and kings of the highly social termite Macrotermes natalensis. Using transcriptomics, lipidomics and metabolomics, this study shows that several aging-related processes are reduced in the fat bodies of these reproductives and that an upregulated insulin-like peptide, Ilp9, does not lead to deleterious fat storage in old queens, while simple sugars dominate in their hemolymph.
Published: 2021

23. Assessing the accuracy of a new hand hygiene monitoring device (SmartRub®): from the laboratory to clinical practice

Author: Nasim Lotfinejad, Daniela Pires, Chloé Guitart, Simon Fourquier, Rene Beuchat, Yves Martin, Yves-Alain Robert, Didier Pittet, and Julien Sauser
Subjects: Microbiology (medical), medicine.medical_specialty, media_common.quotation_subject, Hand Sanitizers, Hospital acquired infections, Infectious and parasitic diseases, RC109-216, Sensitivity and Specificity, Sensitivity, Hygiene, Predictive Value of Tests, Positive predicative value, Internal medicine, medicine, Humans, Pharmacology (medical), Hand Hygiene, Clinical care, media_common, business.industry, Research, Public Health, Environmental and Occupational Health, Reproducibility of Results, Clinical Practice, Infectious Diseases, Electronic monitoring device, Specificity, business
Abstract: Background We developed SmartRub® powered by iQati®, an electronic device composed of a wristband and an alcohol-based handrub pocket-sized dispenser that measures and provides feedback on the duration of hand friction and the volume poured during each hand hygiene action. We aimed to assess the accuracy of SmartRub®. Methods The specificity, sensitivity, positive and negative predictive values (PPV and NPV) of SmartRub® were assessed in a 3-phased experiment: (1) laboratory-controlled conditions with volunteers; (2) pre-planned clinical path with volunteers and (3) real clinical conditions with healthcare workers. The accuracy of SmartRub® was evaluated by quantifying its ability to correctly capture true hand hygiene actions and to not record other actions performed while wearing the device. Results In the laboratory, 7 volunteers performed 816 actions. Overall sensitivity was 94.1% (95% CI 91.4–96.2%) with a PPV of 99.0% (95% CI 97.3–99.6%) and specificity was 99.0% (95% CI 97.5–99.7%) with a NPV of 94.4% (95% CI 91.9–96.1%). During the pre-planned clinical path phase, 13 volunteers performed 98 planned paths and a total of 967 actions were performed. Overall sensitivity was 94.6% (95% CI 92.2–96.5%) with a PPV of 84.3% (95% CI 81.6–86.7%) and specificity was 82.4% (95% CI 78.7–85.7%) with a NPV of 93.9% (95% CI 91.3–95.7%). During the real clinical conditions phase, 17 healthcare workers were observed for a total of 15 h and 3 min while they performed 485 actions. Sensitivity was 96.8% (95% CI 93.8–98.6%) with a PPV of 98.3% (95% CI 95.6–99.3%) and specificity was 98.3% (95% CI 95.7–99.5%) with a NPV of 96.8% (95% CI 93.9–98.4%). Conclusions Smartrub® is a highly reliable device for capturing hand hygiene actions under a range of conditions, from the laboratory to clinical care activities.
Published: 2021

24. The MICROSCOPE space mission: the first test of the equivalence principle in a space laboratory

Author: Pierre Touboul, Gilles Métris, Manuel Rodrigues, Joel Bergé, Ratana Chhun, Bernard Foulon, and Alain Robert
Subjects: Physics and Astronomy (miscellaneous)
Abstract: This paper introduces the current special issue focussed on the MICROSCOPE mission. This mission is the first experimental test in space of the weak equivalence principle (WEP) using man-made test-masses—as opposed to astronomical tests—with the goal to reach a precision two orders of magnitude better than ground-based experiments. Selected in 1999 by CNES as part of its MYRIADE microsatellite programme, the satellite was launched in 2016 and the mission lasted 2.5 years. This paper summarises the articles of the special issue and highlights the key technological and data analysis aspects that allowed for an unprecedented precision on the test of the WEP.
Published: 2022

25. MICROSCOPE mission scenario, ground segment and data processing

Author: Manuel Rodrigues, Pierre Touboul, Gilles Métris, Judicael Bedouet, Joel Bergé, Patrice Carle, Ratana Chhun, Bruno Christophe, Bernard Foulon, Pierre-Yves Guidotti, Stephanie Lala, and Alain Robert
Subjects: Physics - Instrumentation and Detectors, Physics and Astronomy (miscellaneous), FOS: Physical sciences, Physics - Applied Physics, General Relativity and Quantum Cosmology (gr-qc), Applied Physics (physics.app-ph), Instrumentation and Detectors (physics.ins-det), Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), General Relativity and Quantum Cosmology
Abstract: Testing the Weak Equivalence Principle (WEP) to a precision of $10^{-15}$ requires a quantity of data that give enough confidence on the final result: ideally, the longer the measurement the better the rejection of thestatistical noise. The science sessions had a duration of 120 orbits maximum and were regularly repeated and spaced out to accommodate operational constraints but also in order to repeat the experiment in different conditions and to allow time to calibrate the instrument. Several science sessions were performed over the 2.5 year duration of the experiment. This paper aims to describe how the data have been produced on the basis of a mission scenario and a data flow process, driven by a tradeoff between the science objectives and the operational constraints. The mission was led by the Centre National d'Etudes Spatiales (CNES) which provided the satellite, the launch and the ground operations. The ground segment was distributed between CNES and Office National d'Etudes et de Recherches A\'erospatiales (ONERA). CNES provided the raw data through the Centre d'Expertise de Compensation de Tra\^{i}n\'{e}e (CECT: Drag-free expertise centre). The science was led by the Observatoire de la C\^ote d{'}Azur (OCA) and ONERA was in charge of the data process. The latter also provided the instrument and the Science Mission Centre of MICROSCOPE (CMSM)., Comment: To be released in special MICROSCOPE edition of CQG
Published: 2022

26. MICROSCOPE mission: statistics and impact of glitches on the test of the weak equivalence principle *

Author: Joel Bergé, Quentin Baghi, Alain Robert, Manuel Rodrigues, Bernard Foulon, Emilie Hardy, Gilles Métris, Sandrine Pires, and Pierre Touboul
Subjects: Physics and Astronomy (miscellaneous)
Abstract: MICROSCOPE’s space test of the weak equivalence principle (WEP) is based on the minute measurement of the difference of accelerations experienced by two test masses as they orbit the Earth. A detection of a violation of the WEP would appear at a well-known frequency f EP depending on the satellite’s orbital and spinning frequencies. Consequently, the experiment was optimised to minimise systematic errors at f EP. Glitches are short-lived events visible in the test masses’ measured acceleration, most likely originating in cracks of the satellite’s coating. In this paper, we characterise their shape and time distribution. Although intrinsically random, their time of arrival distribution is modulated by the orbital and spinning periods. They have an impact on the WEP test that must be quantified. However, the data available prevents us from unequivocally tackling this task. We show that glitches affect the test of the WEP, up to an a priori unknown level. Discarding the perturbed data is thus the best way to reduce their effect.
Published: 2022

27. MICROSCOPE. mission analysis, requirements and expected performance

Author: Pierre-Yves Guidotti, Bruno Christophe, Pierre Touboul, Vincent Lebat, Pascal Prieur, Gilles Metris, Manuel E. Rodrigues, Damien Boulanger, Joel Bergé, Phuong-Anh Huynh, Ratana Chhun, Benjamin Pouilloux, Valerio Cipolla, Françoise Liorzou, Alain Robert, Serge Reynaud, Quentin Baghi, Bernard Foulon, Emilie Hardy, DPHY, ONERA, Université Paris Saclay [Châtillon], ONERA-Université Paris-Saclay, Centre National d'Études Spatiales [Toulouse] (CNES), Laboratoire Kastler Brossel (LKB [Collège de France]), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution))
Subjects: Systematic error, Microscope, Physics and Astronomy (miscellaneous), FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), Accelerometer, 01 natural sciences, General Relativity and Quantum Cosmology, law.invention, Gravitational field, law, 0103 physical sciences, Mission analysis, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Ground segment, Aerospace engineering, 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Physics, 010308 nuclear & particles physics, business.industry, Physics::Space Physics, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], Trajectory, Satellite, Astrophysics - Instrumentation and Methods for Astrophysics, business
Abstract: The MICROSCOPE mission aimed to test the Weak Equivalence Principle (WEP) to a precision of $10^{-15}$. The WEP states that two bodies fall at the same rate on a gravitational field independently of their mass or composition. In MICROSCOPE, two masses of different compositions (titanium and platinum alloys) are placed on a quasi-circular trajectory around the Earth. They are the test-masses of a double accelerometer. The measurement of their accelerations is used to extract a potential WEP violation that would occur at a frequency defined by the motion and attitude of the satellite around the Earth. This paper details the major drivers of the mission leading to the specification of the major subsystems (satellite, ground segment, instrument, orbit...). Building upon the measurement equation, we derive the objective of the test in statistical and systematic error allocation and provide the mission's expected error budget., References updated
Published: 2022

28. Microscope instrument in-flight characterization

Author: Ratana Chhun, Emilie Hardy, Manuel Rodrigues, Pierre Touboul, Gilles Métris, Joel Bergé, Damien Boulanger, Bruno Christophe, Pascale Danto, Bernard Foulon, Pierre-Yves Guidotti, Phuong-Anh Huynh, Vincent Lebat, Françoise Liorzou, Alain Robert, DPHY, ONERA, Université Paris Saclay [Châtillon], ONERA-Université Paris-Saclay, Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), and Centre National d'Études Spatiales [Toulouse] (CNES)
Subjects: Physics - Instrumentation and Detectors, Physics and Astronomy (miscellaneous), [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], FOS: Physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], General Relativity and Quantum Cosmology (gr-qc), Instrumentation and Detectors (physics.ins-det), Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), General Relativity and Quantum Cosmology
Abstract: Since the MICROSCOPE instrument aims to measure accelerations as low as a few 10$^{-15}$\,m\,s$^{-2}$ and cannot operate on ground, it was obvious to have a large time dedicated to its characterization in flight. After its release and first operation, the characterization experiments covered all the aspects of the instrument design in order to consolidate the scientific measurements and the subsequent conclusions drawn from them. Over the course of the mission we validated the servo-control and even updated the PID control laws for each inertial sensor. Thanks to several dedicated experiments and the analysis of the instrument sensitivities, we have been able to identify a number of instrument characteristics such as biases, gold wire and electrostatic stiffnesses, non linearities, couplings and free motion ranges of the test-masses, which may first impact the scientific objective and secondly the analysis of the instrument good operation., Comment: This paper is part of set of articles dedicated to the final results of MICROSCOPE space mission and submitted to CQG
Published: 2022

29. MICROSCOPE: systematic errors

Author: Manuel Rodrigues, Pierre Touboul, Gilles Métris, Alain Robert, Océane Dhuicque, Joel Bergé, Yves André, Damien Boulanger, Ratana Chhun, Bruno Christophe, Valerio Cipolla, Pascale Danto, Bernard Foulon, Pierre-Yves Guidotti, Emilie Hardy, Phuong-Anh Huynh, Vincent Lebat, Françoise Liorzou, Benjamin Pouilloux, Pascal Prieur, Serge Reynaud, and Patrizia Torresi
Subjects: Physics - Instrumentation and Detectors, Physics and Astronomy (miscellaneous), FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), Applied Physics (physics.app-ph), Instrumentation and Detectors (physics.ins-det), Physics - Applied Physics, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), General Relativity and Quantum Cosmology
Abstract: The MICROSCOPE mission aims to test the Weak Equivalence Principle (WEP) in orbit with an unprecedented precision of 10$^{-15}$ on the E\"otv\"os parameter thanks to electrostatic accelerometers on board a drag-free micro-satellite. The precision of the test is determined by statistical errors, due to the environment and instrument noises, and by systematic errors to which this paper is devoted. Systematic error sources can be divided into three categories: external perturbations, such as the residual atmospheric drag or the gravity gradient at the satellite altitude, perturbations linked to the satellite design, such as thermal or magnetic perturbations, and perturbations from the instrument internal sources. Each systematic error is evaluated or bounded in order to set a reliable upper bound on the WEP parameter estimation uncertainty., Comment: To be released in CQG MICROSCOPE Special Edition
Published: 2022

30. The pyrethroid insecticides permethrin and esfenvalerate do not disrupt testicular steroidogenesis in the rat fetus

Author: Ethel Eljarrat, Guillaume Antoine, Flavien Denis, Jean-Philippe Sabaté, Anne-Marie Saillenfait, and Alain Robert
Subjects: Male, 0301 basic medicine, Insecticides, medicine.medical_specialty, 010501 environmental sciences, Biology, Toxicology, 01 natural sciences, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Pregnancy, Internal medicine, Nitriles, Pyrethrins, Testis, parasitic diseases, medicine, Animals, Gonadal Steroid Hormones, Permethrin, Testosterone, 0105 earth and related environmental sciences, Fetus, Pyrethroid, Dose-Response Relationship, Drug, Cholesterol side-chain cleavage enzyme, Body Weight, Neurotoxicity, Gene Expression Regulation, Developmental, medicine.disease, Rats, 030104 developmental biology, Endocrinology, chemistry, Maternal Exposure, In utero, Prenatal Exposure Delayed Effects, Female, Neurotoxicity Syndromes, Steroids, Esfenvalerate, medicine.drug
Abstract: The present study investigated the effects of maternal exposure to the widely used pyrethroid insecticides, permethrin and esfenvalerate, on fetal testicular steroidogenesis. Pregnant Sprague-Dawley rats were administered permethrin at doses of 1, 10, 50, or 100 mg/kg/day, or esfenvalerate at 0.1, 1, 7.5 or 15 mg/kg/day, by gavage, from gestation day (GD) 13 to 19. Testicular testosterone production and the expression of several key genes necessary for cholesterol and androgen synthesis and transport were assessed in GD 19 male fetuses. Dams treated with 100 mg/kg/day of permethrin or 15 mg/kg/day of esfenvalerate showed clinical signs of neurotoxicity. The highest dose of esfenvalerate also resulted in reduced maternal body weight gain throughout the treatment period. In the fetal testes, mRNA expressions of HMG-CoA synthase and reductase, SR-B1, StAR, P450scc, 3βHSD, P450 17A1, and 17βHSD were not affected by exposure to either pyrethroid. No significant change was observed in ex vivo testosterone production. In conclusion, in utero exposure to permethrin or esfenvalerate has no effect on the testosterone biosynthesis pathway in the fetal rat testis up to maternal toxic doses.
Published: 2018

31. Continuous enteral nutrition compared with a maximal gastric vacuity strategy at the time of extubation in the intensive care unit: protocol for a non-inferiority cluster randomised trial (the Ambroisie Project)

Author: Stephan Ehrmann, Anne Rebion, Jean Reignier, Johann Auchabie, Bruno Giraudeau, Mai-Anh Nay, Arnaud W. Thille, Elsa Tavernier, Noemie Hubert, Alain Robert, Mickael Landais, Centre Hospitalier Le Mans (CH Le Mans), Centre Hospitalier Régional d'Orléans (CHRO), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université - Faculté de Médecine (SU FM), Sorbonne Université (SU), Centre d’Investigation Clinique [Tours] CIC 1415 (CIC ), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), Centre hospitalier universitaire de Nantes (CHU Nantes), CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, and Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS)
Subjects: Adult, intensive & critical care, medicine.medical_specialty, Critical Illness, [SDV]Life Sciences [q-bio], nutritional support, Disease cluster, law.invention, 03 medical and health sciences, 0302 clinical medicine, Non inferiority, Enteral Nutrition, Informed consent, law, medicine, Intubation, Intratracheal, Humans, 030212 general & internal medicine, adult intensive & critical care, Randomized Controlled Trials as Topic, Protocol (science), Critically ill, business.industry, Intensive Care, General Medicine, Intensive care unit, 3. Good health, Intensive Care Units, Parenteral nutrition, 030228 respiratory system, Concomitant, Emergency medicine, Airway Extubation, Medicine, business
Abstract: IntroductionFasting is frequently imposed to patients before extubation in the intensive care unit based on scheduled surgery guidelines. This practice has never been evaluated among critically ill patients and may delay extubation, increase nursing workload and reduce caloric intake. We are hypothesising that continuous enteral nutrition until extubation represents a safe alternative compared with fasting prior to extubation in the intensive care unit.Methods and analysisAdult patients ventilated more than 48 hours and receiving pre-pyloric enteral nutrition for more than 24 hours are included in this open-label cluster randomised parallel group non-inferiority trial. The participating centres are randomised allocated to continued enteral nutrition until extubation or 6-hour fasting (with concomitant gastric suctioning when feasible) prior to extubation. The primary outcome is extubation failure (ie, reintubation within 7 days following extubation).Ethics and disseminationThis study has been approved by the national ethics review board (comité de protection, des personnes Sud Mediterranée III No 2017.10.02 bis) and patients are included after informed consent. Results will be submitted for publication in peer-reviewed journals.Trial registration numberClinicalTrials.gov Registry (NCT03335345).
Published: 2021

32. Biomonitoring of occupational exposure to bisphenol A, bisphenol S and bisphenol F: A systematic review

Author: Nadine Fréry, Radia Bousoumah, Veruscka Leso, Alain Robert, Simo P. Porras, Tiina Santonen, Pasi Huuskonen, Sophie Ndaw, Susana Viegas, Ivo Iavicoli, Bousoumah, R., Leso, V., Iavicoli, I., Huuskonen, P., Viegas, S., Porras, S. P., Santonen, T., Frery, N., Robert, A., and Ndaw, S.
Subjects: Bisphenol A, Sulfone, Environmental Engineering, Asia, 010504 meteorology & atmospheric sciences, Bisphenol F, Bisphenol, Horizon 2020 no. 733032, Bisphenols, 010501 environmental sciences, 01 natural sciences, chemistry.chemical_compound, Phenols, Project HBM4EU, Environmental health, Occupational Exposure, Biomonitoring, Environmental Chemistry, Medicine, Humans, Sulfones, Benzhydryl Compounds, Waste Management and Disposal, 0105 earth and related environmental sciences, Exposure assessment, Benzhydryl Compound, Occupational health, Phenol, business.industry, Endocrine disrupters, Endocrine disrupter, Occupational exposure, Pollution, Europe, Systematic review, Bisphenol S, chemistry, 13. Climate action, business, Human, Biological Monitoring
Abstract: Bisphenol A (BPA) and its substitutes bisphenol S (BPS) and bisphenol F (BPF) are endocrine disrupting chemicals widely used in the production of polycarbonate plastics, epoxy resins and thermal papers. The aim of the review was to identify occupational studies using human biomonitoring (HBM) as a tool for bisphenol exposure assessment and to characterize research gaps on the topic as part of the HBM4EU project. Hence, a systematic literature search using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology was conducted for articles published between 2000 and 27th March 2020 across three databases (PubMed, Scopus and Web of Science). Thirty studies on the occupational HBM of BPA met the inclusion criteria. Regarding BPS and BPF, only 4 and 2 publications were retrieved, respectively. Fifty-seven percent (57%) of the studies selected for BPA were conducted in Asia whereas half of BPS and BPF studies were undertaken in Europe. Studies on BPA in plastic and epoxy resin sectors were infrequent in Europe while Asian data showed higher exposure when the substance is employed as raw material. The main data on BPS were among cashiers while BPF data were available from incinerator workers. Several research gaps have been identified: (i) shortage of HBM studies on occupational exposure, especially to BPS and BPF; (ii) different methodological designs making suitable comparisons between studies difficult; and (iii) only few studies conducted on the industrial applications of bisphenols outside Asia. This review highlights the lack of recent occupational HBM studies on bisphenols and the need for a harmonized approach to acquire reliable data. Considering the increasing replacement of BPA by BPS and BPF, it is of relevance to evaluate the exposure to these substances and the impact of the available risk management measures on workers exposure and possible health risk.
Published: 2021

33. Investigating Multi-Mycotoxin Exposure in Occupational Settings: A Biomonitoring and Airborne Measurement Approach

Author: Guillaume Antoine, Flavien Denis, Alain Robert, Sophie Ndaw, Sandrine Melin, and Daniele Jargot
Subjects: Ochratoxin A, Aflatoxin, endocrine system, Spectrometry, Mass, Electrospray Ionization, animal structures, exposure assessment, air, Health, Toxicology and Mutagenesis, HR-MS/MS, lcsh:Medicine, Pilot Projects, 010501 environmental sciences, Urine, Toxicology, 01 natural sciences, Article, chemistry.chemical_compound, Tandem Mass Spectrometry, Biomonitoring, Humans, Food science, Mycotoxin, Ochratoxin, Zearalenone, Occupational Health, 0105 earth and related environmental sciences, Exposure assessment, Fumonisin B1, Air Pollutants, lcsh:R, 010401 analytical chemistry, technology, industry, and agriculture, food and beverages, occupational exposure, Mycotoxins, 0104 chemical sciences, body regions, chemistry, biomonitoring, Environmental science, dust, Biological Monitoring, Chromatography, Liquid
Abstract: Investigating workplace exposure to mycotoxins is of the utmost importance in supporting the implementation of preventive measures for workers. The aim of this study was to provide tools for measuring mycotoxins in urine and airborne samples. A multi-class mycotoxin method was developed in urine for the determination of aflatoxin B1, aflatoxin M1, ochratoxin A, ochratoxin &alpha, deoxynivalenol, zearalenone, &alpha, zearalenol, &beta, zearalenol, fumonisin B1, HT2-toxin and T2-toxin. Analysis was based on liquid chromatography&ndash, high resolution mass spectrometry. Sample pre-treatments included enzymatic digestion and an online or offline sample clean-up step. The method was validated according to the European Medicines Agency guidance procedures. In order to estimate external exposure, air samples collected with a CIP 10 (Capteur Individuel de Particules 10) personal dust sampler were analyzed for the quantification of up to ten mycotoxins, including aflatoxins, ochratoxin A, deoxynivalenol, zearalenone, fumonisin B1 and HT-2 toxin and T-2 toxin. The method was validated according to standards for workplace exposure to chemical and biological agents EN 482. Both methods, biomonitoring and airborne mycotoxin measurement, showed good analytical performances. They were successfully applied in a small pilot study to assess mycotoxin contamination in workers during cleaning of a grain elevator. We demonstrated that this approach was suitable for investigating occupational exposure to mycotoxins.
Published: 2021

34. Environmental transition alignment and portfolio performance

Author: Peter Tankov, Alain Robert-Dautun, Olivier Guéant, and Jean-Guillaume Peladan
Subjects: Investment decisions, Transition (fiction), Econometrics, Economics, Portfolio, Metric (unit)
Abstract: We contribute to the debate on whether using ESG/SRI criteria in investment decisions improves portfolio performance. The choice of a specific ESG metric being crucial, we focus on the Net Environmental Contribution, a robust open-source measure of environmental transition alignment. From a universe of 752 European stocks, we select subsets of stocks with high and low NEC scores, and compare the performance of equal-weighted and capitalization-weighted portfolios constructed from these subsets over the 2015-2020 period. The high-NEC portfolios outperform the low-NEC ones consistently throughout the period, and particularly during 18 months starting mid-2019, both before and during the COVID crisis.
Published: 2021

35. MICROSCOPE mission: Data analysis principle

Author: Joel Bergé, Quentin Baghi, Emilie Hardy, Gilles Métris, Alain Robert, Manuel Rodrigues, Pierre Touboul, Ratana Chhun, Pierre-Yves Guidotti, Sandrine Pires, Serge Reynaud, Laura Serron, Jean-Michel Travert, DPHY, ONERA, Université Paris Saclay [Châtillon], ONERA-Université Paris-Saclay, Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Centre National d'Études Spatiales [Toulouse] (CNES), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire Kastler Brossel (LKB [Collège de France]), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution))
Subjects: Physics and Astronomy (miscellaneous), [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), General Relativity and Quantum Cosmology
Abstract: After performing highly sensitive acceleration measurements during two years of drag-free flight around the Earth, MICROSCOPE provided the best constraint on the Weak Equivalence Principle (WEP) to date. Beside being a technological challenge, this experiment required a specialised data analysis pipeline to look for a potential small signal buried in the noise, possibly plagued by instrumental defects, missing data and glitches. This paper describes the frequency-domain iterative least-square technique that we developed for MICROSCOPE. In particular, using numerical simulations, we prove that our estimator is unbiased and provides correct error bars. This paper therefore justifies the robustness of the WEP measurements given by MICROSCOPE., References updated
Published: 2020

36. MICROSCOPE Satellite and its Drag-Free and Attitude Control System

Author: Pierre Touboul, Bruno Christophe, Valerio Cipolla, Thomas Lienart, Benjamin Pouilloux, Yves André, Ratana Chhun, Emilie Hardy, Françoise Liorzou, Manuel Rodrigues, Damien Boulanger, Pierre-Yves Guidotti, Pascal Prieur, Vincent Lebat, Joel Bergé, Alain Robert, Gilles Métris, Centre National d'Études Spatiales [Toulouse] (CNES), ONERA - The French Aerospace Lab [Châtillon], ONERA-Université Paris Saclay (COmUE), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])
Subjects: Physics, Attitude control system, Microscope, Physics and Astronomy (miscellaneous), business.industry, FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), 7. Clean energy, Space Physics (physics.space-ph), General Relativity and Quantum Cosmology, law.invention, Physics - Space Physics, Drag, law, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], Satellite, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Aerospace engineering, business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract: This paper focus on the description of the design and performance of the MICROSCOPE satellite and its Drag-Free and Attitude Control System (DFACS). The satellite is derived from CNES' Myriade platform family, albeit with significant upgrades dictated by the unprecedented MICROSCOPE's mission requirements. The 300kg drag-free microsatellite has completed its 2-year flight with higher-than-expected performances. Its passive thermal concept allowed for variations smaller than 1 $\mu$K at the measurement frequency $f_{\rm{EP}}$. The propulsion system provided a 6 axis continuous and very low noise thrust from zero to some hundreds of micronewtons. Finally, the performance of its DFACS (aimed at compensating the disturbing forces and torques applied to the satellite) is the finest ever achieved in low Earth orbit, with residual accelerations along the three axes are lower than $10^{-12} {\rm m/s}^2$ at $f_{\rm{EP}}$ over 8 days., Comment: References updated
Published: 2020

37. Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients

Author: Cécile Couchoud, Florian Bayer, Carole Ayav, Clémence Béchade, Philippe Brunet, François Chantrel, Luc Frimat, Roula Galland, Maryvonne Hourmant, Emmanuelle Laurain, Thierry Lobbedez, Lucile Mercadal, Olivier Moranne, Abdelhamid Abbassi, Alain Debure, Abdallah Guerraoui, Abdelatif Benmoussa, Abdelaziz Hamani, Abdelaziz Ziane, Abdelhamid Nefti, Abdelkader Hadj, Abderrahim El Amari, Abderrahmane Ghazali, Abo Bakr Abd El Fatah Mohamed, Achour Laradi, Adel Ben Ahmed, Adel Sahar, Adele Pillet, Adeline Lacraz, Adnan Moinat, Afshin Massoumi, Agathe Pardon, Agnes Caillette Beaudoin, Agnes Chapelet Debout, Agnes Mariot, Ahmed Rachi, Aida Afiani, Aime Remy Boula, Al Jalaby, Alain Cremault, Alain Fournier, Alain Jeanson, Alain Lyon, Alain Nony, Alain Robert, Alain Slingeneyer, Alanor Agnes Labatide, Albane Brodin Sartorius, Albert Bensman, Albert Fournier, Alex Ranlin, Alex Vido Sandor, Alexandra Colombo, Alexandra Duhem, Alexandra Stancu, Alexandre Dufay, Alexandre Dumoulin, Alexandre Ebel, Alexandre Klein, Alexandre Martin, Alexandre Mouneimne, Alexandre Seidowsky, Alfio De Martin, Alfredo Zannier, Ali Aizel, Ali Hafi, Ali Zineddine Diddaoui, Alim Heyani, Alina Mocanu, Alina Preda, Aline Hafi, Aline Talaszka, Alyette Duquesne, Amar Amaouche, Amel Ghemmour, Amelie Simon, Amina Skalli, Amine Boukadida, Amr Ekhlas Ragab Eid, Ana Fedorca, Anabelle Baillet, Anais Poyet, Ancuta Bouffandeau Giorgita, Anderson Ratsimbazafy, Andre Pruna, Angel Argiles, Angelo Testa, Ann Karolien Vandooren, Anne Jolivot, Anne Kolko Labadens, Anne Lataste, Anne Maisin, Anne Paris, Anne Sechet, Anne Wuillai, Anne Elisabeth Heng, Anne Gaelle Josse, Anne Helene Querard, Anne Helene Reboux, Anne Laure Adra, Anne Laure Faller, Anne Laure Leclerc, Anne Laure Poitou, Annie Lahoche Manucci, Antoine Jacquet, Antoine Pommereau, Antoine Thierry, Arezki Adem, Arielle Chapelet, Arnaud Del Bello, Arnaud Delezire, Arnaud Garnier, Arnaud Guerard, Arnaud Klisnick, Arnaud Lionet, Arnaud Roccabianca, Arnaud Stolz, Arthur Capdeville, Asma Allal, Assem Alrifai, Assetou Diarrassouba, Assia Djema, Assia Ferhat Carre, Astrid Godron Dubrasquet, Atman Haddj Elmrabet, Audrey Jegado, Aurelia Bertholet Thomas, Aurelie Davourie Salandre, Aurelie Pajot, Aurelien Lorthioir, Aurelien Tiple, Aurore Sury, Ayman Abokasem, Ayman Sarraj, Bachir Henaoui, Baher Chaghouri, Bassem Wehbe, Beatrice Ball, Beatrice Viron, Belkassem Issad, Benedicte Hodemon Corne, Benedicte Janbon, Benjamin Deroure, Benjamin Savenkoff, Benoit Jonon, Benoit Vendrely, Benyakoub Djelaleddine, Bernard Ohry, Bernard Painchart, Bernard Strullu, Bernard Temperville, Bertin Ebikili, Bertrand Hacq, Bertrand Morel, Bilal Aoun, Blanca Muniz, Bouchra Chlih, Brahim Amara, Brice Mayor, Brigitte Gilson, Brigitte Llanas, Brigitte Zins, Bruno Bourgeon, Bruno Coevoet, Bruno Guery, Bruno Legallicier, Bruno Paris, Bruno Ranchin, Bruno Seigneuric, Camelia Ghiciuc Dita, Camelia Prelipcean, Carine Achard Hottelart, Carine Diet, Carlos Frangie, Carlos Vela, Carmina Muresan, Carole Deprele, Caroline Araujo, Caroline Bidault, Caroline Creput, Caroline Delclaux, Caroline Du Halgouet, Caroline Favennec, Caroline Freguin, Caroline Gourraud Vercel, Caroline Mesguen, Caroline Ndomo Obama, Caroline Poitou, Caroline Preissig Dirhold, Caroline Roubiou, Catherine Albert, Catherine Bessin, Catherine De Marion Gaja, Catherine Godart, Catherine Lasseur, Catherine Leocardi, Catherine Lumbroso, Catherine Melander, Catherine Michel, Catherine Quere Maurouard, Catherine Rouannet, Catherine Taddei, Cathy Verove, Cecile Guiraud, Cecile Tafelin, Cecile Turc Baron, Cedric Formet, Cedric Pinier, Celia Lessore De Ste Foy, Celine Granolleras, Chaouki Bennini, Charles Cartou, Charles Chazot, Charlotte Jouzel, Cherif Badid, Christa Roubicek, Christel Viaud, Christelle Verrier, Christian Chuet, Christian Combe, Christian Dabot, Christian Duvic, Christian Emond, Christian Lagarde, Christian Lamotte, Christian Pain, Christiane Mousson, Christie Lorriaux, Christine Beauchamp, Christine Fumeron, Christine Le Gurun, Christine Leroy, Christine Pietrement, Christine Richer, Christophe Bouaka, Christophe Charasse, Christophe Goupy, Christophe Ridel, Cindy Castrale, Cindy Detourne, Clair Francois, Claire Presne, Claire Trivin, Clarissa Von Kotze, Claude Bernard, Claude Bonniol, Claude Desvergnes, Claude Raharivelina, Claudia Nistor, Claudine Gueret, Claudine Lloret, Claudine Saltiel, Clelia Rosati, Clementine Rabate, Corina Stanescu, Corinne Ferrandini, Corinne Guibergia, Corinne Lemoine, Corinne Passeron, Cynthia Kahil, Cyril Garrouste, Cyril Vo Van, Cyrille Jolimoy, Dalila Kesraoui, Damien Jolly, Damien Thibaudin, Dan Teboulle, Daniel Daubresse, Daniel Louvet, Daniel Rasamimanantsoa, Daniel Toledano, Daniela Babici, Daniela David, Daniela Dincu, Danielle Bruno, Delia May, Delphine Haussaire, Delphine Henriet Viprey, Denis Bugnon, Denis Fouque, Denis Morin, Derradji Nour, Diab Mohamed Mahmoud, Diana Istrati Cristescu, Didier Aguilera, Didier Coste, Didier Hamel, Didier Le Chapois, Didier Testou, Dilaver Erbilgin, Djamal Dahmane, Doan Bui Quang, Dominique Bertrand, Dominique Besnier, Dominique Blanchier, Dominique Briffa, Dominique Caux, Dominique Durand, Dominique Fleury, Dominique Guerrot, Dominique Hestin, Dominique Jaubert, Dominique Joly, Dominique Lombart, Dominique Pagniez, Dominique Pierre, Dominique Schohn, Donatien Ikonga, Dorina Visanica, Dorothee Bazin, Edouard Boury, Edouard Maksour, Ekoue Agbonon, Elarbi Harrami, Elena Marcu, Elena Tudorache, Elisabeth Caniot, Elisabeth Semjen, Elisabeth Tomkiewicz, Elise Scheidt, Elke Gaboriau, Elodie Lamouroux, Elsa Guiard, Elsa Martin Passos, Emerson Nsembani, Emilie Fache, Emilie Kalbacher, Emilie Pambrun, Emilie Pincon, Emma Allain Launay, Emmanuel Baron, Emmanuel Dupuis, Emmanuel Villar, Emmanuelle Charlin, Emmanuelle Hecquet, Emmanuelle Kohler, Emmanuelle Rosier, Enrique Figueroa, Eric Azoulay, Eric Canivet, Eric Daugas, Eric Gauthier, Eric Laruelle, Eric Le Guen, Eric Legrand, Eric Moumas, Eric Postec, Eric Prinz, Eric Renaudineau, Estelle Desport, Estelle Ricard Sutra, Etienne Berard, Etienne Ged, Etienne Robin, Eve Vilaine, Evelyne Bargas, Evelyne Mac Namara, François Combarnous, Fatima Yazbeck, Fabien Gerard, Fabien Metivier, Fabien Parazols, Fabien Soulis, Fabrice Garnier, Fadhila Pech Messaoudene, Fadi Haidar, Fanny Boullenger, Fanny Lepeytre, Fanny Leroy, Fares Frejate, Farid Bellahsene, Farid Bellhasene, Farid Saidani, Fatouma Toure, Faycal Kriaa, Fazia Nemmar, Fernando Vetromile, Florence Chalmin, Florence Lucats, Florence Sens, Florence Villemain, Florent Plasse, Fouad Lebhour, Francis Schillinger, Franck Berge, Franck Bourdon, Franck Bridoux, Franck Reynaud, Francois Babinet, Francois Basse, Francois Chantrel, Francois Clair, Francois Coulomb, Francois De Cornelissen, Francois Glowacki, Francois Marchal, Francois Maurice, Francois Nobili, Francois Pourreau, Francois Provot, Francois Roux Amani, Francoise Broux, Francoise Bulte, Francoise Heibel, Francoise Leonetti, Francoise Moussion Schott, Frank Le Roy, Frederic Besson, Frederic Lavainne, Frederic Tollis, Frederique Bocquentin, Frederique Meeus, Frederique Vecina, Friederike Von Ey, Gabriel Balit, Gabriel Choukroun, Gabriel Gruget, Gabriel Huchard, Gabriella Golea, Gabrielle Duneau, Gaelle Lefrancois, Gaelle Pelle, Gaetan Lebrun, Genevieve Dumont, Georges Brillet, Georges Deschenes, Georges Mourad, Georges Stamatakis, Geraldine Cazajous, Geraldine D'ythurbide, Geraldine Robitaille Wiart, Gerard Cardon, Gerard Champion, Gerard Deschodt, Gerard Mangenot, Gerard Motte, Gerard Schortgen, Ghada Boulahia, Ghassan Maakaroun, Ghylene Bourdat Michel, Gilbert Zanetta, Gilles Hufnagel, Gilles Messier, Giorgina Piccoli, Gregoire Couvrat Desvergnes, Guillaume Bobrie, Guillaume Bonnard, Guillaume Clement, Guillaume Jean, Guillaume Queffeulou, Guillaume Seret, Guillaume Vernin, Guy Delavaud, Guy Lambrey, Guy Rostoker, Gwenaelle Poussard, Gwenaelle Roussey Kesler, H. Leon, Habib Aboubekr, Hacene Boulechfar, Hacene Sekhri, Hadia Hebibi, Hadjira Benalia, Hafed Fessi, Hafsabhai Atchia, Haiat Bittar, Hakim Maiza, Hakim Mazouz, Hamid El Ali, Hammouche Bougrida, Hans Van Der Pijl, Hassan Lokmane, Hassane Izzedine, Hassen Adda, Helene De Preneuf, Helene Leray, Helene Philippot, Henri Boulanger, Henri Merault, Henri Renaud, Herve Bonarek, Herve Maheut, Hilaire Nzeyimana, Hocine Mehama, Hocine Zaidi, Hugo Weclawiak, Hugues Flodrops, Huseyin Karaaslan, Ibrahim Haskour, Ihssen Belhadj, Imad Almoubarak, Imad Haddad, Ines Castellano, Ines Ferrandiz, Ioana Daniliuc, Ioana Darie, Ioana Enache, Ionut Prunescu, Irenee Djiconkpode, Irina Shahapuni, Isabelle Bouchoule, Isabelle Devriendt, Isabelle Kazes, Isabelle Kolb, Isabelle Landru, Isabelle Poli, Isabelle Rey, Isabelle Segalen, Isabelle Selcer, Isabelle Vernier, Isabelle Vrillon, Ismahane Guenifi, J. Dominique Gheerbrandt, Jacky Potier, Jacques Becart, Jacques Cledes, Jacques Ducros, Jacques Duvic, Jacques Fourcade, Jacques Gaultier, Jacques Jurine, Jacques Lebleu, Jacques Ollier, Jacques Ibsen Charles, Jamal Yazji, Janette Mansour, Jean Arnautou, Jean Brocard, Jean Carolfi, Jean Montoriol, Jean Baptiste Gouin, Jean Bernard Palcoux, Jean Christophe Bendini, Jean Claude Aldigier, Jean Claude Alphonse, Jean Daniel Delbet, Jean Francois Bonne, Jean Francois Cantin, Jean Francois De Fremont, Jean Francois Dessassis, Jean Francois Subra, Jean Francois Valentin, Jean Francois Verdier, Jean Jacques Dion, Jean Jacques Haultier, Jean Jacques Montseny, Jean Louis Bacri, Jean Louis Bouchet, Jean Luc Mahe, Jean Marc Chalopin, Jean Marc Gabriel, Jean Marc Hurot, Jean Marc Lanau, Jean Marie Batho, Jean Marie Coulibaly, Jean Michel Hardin, Jean Michel Marc, Jean Michel Poux, Jean Michel Rebibou, Jean Michel Tivollier, Jean Noel Ottavioli, Jean Paul Faucon, Jean Paul Imiela, Jean Paul Jaulin, Jean Paul Masselot, Jean Paul Ortiz, Jean Philippe Bourdenx, Jean Philippe Devaux, Jean Philippe Hammelin, Jean Pierre Rivory, Jean Pierre Wauquier, Jean Rene Larue, Jean Rene Mondain, Jean Sebastien Borde, Jean Simon Virot, Jean Yves Bosc, Jedjiga Achiche, Jennifer Parasote, Jeremie Diolez, Jerome Harambat, Jerome Potier, Jerome Sampol, Jihad Mustel, Jean Jacques Lefevre, Jocelyne Maurizi, Joel Gamberoni, Joelle Claudeon, Joelle Terzic, Joffrey Rogol, Johnny Sayegh, Jorge Cardozo, Jose Brasseur, Jose Guiserix, Joseph Barsumau, Julie Albaret, Julie Beaume, Julie Sohier Attias, Julien Dehay, Julien Hogan, Julien Journet, Julien Ott, Juliette Baleynaud, Justine Bacchetta, Justine Faucher, Kamel Yousfi, Karim Dardim, Karine Clabault, Karine Moreau, Kedna Thomas, Khaled Sirajedine, Khalil Chedid, Khalil El Kaeoui, Khalil El Karoui, Khedidja Bouachi, Kheira Hue, Khuzama El Nasser, Kodso Akposso, Kristian Kunz, Krzysztof Bijak, Lilia Kihal, L. Rasoloarijaona, Laid Harbouche, Larbi Bencheikh, Larbie Lamriben, Latifa Hanafi, Laura Braun Parvez, Laure Champion, Laure Croze, Laure Eprinchard, Laure Patrier, Laurence Nicolet, Laurence Vrigneaud, Laurent Duflot, Leandre Mackaya, Leila Chenine, Leon Odry, Lili Taghipour Tamiji, Lilia Antri Bouzar, Liliane Ngango Nga Messi, Lionel Le Mouellic, Lise Mandart, Lise Weis, Lise Marie Pouteau, Lora Georgieva, Lorita Vitanova, Lotfi Chalabi, Luc Delvallez, Luc Fromentin, Luc Marty, Luc Monjot, Luciana Spataru, Lucie Bessenay, Lucie Boissinot, Lucie Wajsbrot, Lucien Rakoff, Ludivine Lebourg, Lydie Perez, Lyliane Lafage, Lynda Azzouz, Madeleine Dumoulin, Messaoud Ouziala, Maan Joseph, Mabrouk Brahimi, Maeva Wong Fat, Magalie Fort, Magued Nakhla, Mahdi Abtahi, Mahen Albadawy, Mahmoud Alouach, Mahmoud Mezghani, Maite Daroux, Maklouf Boukelmoune, Malek Dhib, Malik Touam, Malina Dubau, Mamadou Balde, Man Nguyen Khoa, Manfred Ismer, Manolie Mehdi, Manon Laforet, Marc Bouiller, Marc Eugene, Marc Fila, Marc Hazzan, Marc Kribs, Marc Ladriere, Marc Lebot, Marc Padilla, Marc Souid, Marcel Marraoui, Maren Burbach, Maria Manescu, Maria Eugenia Noguera Gonzalez, Mariana Revenco, Marianne Terrasse, Marie Essi, Marie Alice Macher, Marie Beatrice Nogier, Marie Cecile Cazin, Marie Christine Schweitzer Camoin, Marie Christine Thouret, Marie Claude Hannaert, Marie France Servel, Marie Helene Chabannier, Marie Jeanne Coudert Krier, Marie Noelle Catoliquot, Marie Paule Guillodo, Marie Sophie Gavard, Marie Xaviere Vairon Codaccioni, Marina Rabec, Marine Freist, Marion Gauthier, Marion Lemaire, Marion Mehrenberger, Marion Venot, Marios Pongas, Marlene Beaubrun Diant, Martial Levannier, Martine Bertaux, Mathieu Jablonski, Mathieu Sacquepee, Mathilde Dargelos, Mathilde Lemoine, Mathilde Tamain, Matthieu Monge, Matthieu Reberolle, Maud Cousin, Maud Francois, Maurice Baron, Maxime Hoffmann, Maxime Ingwiller, Maxime Touzot, Mederick Mohajer, Mehadji Maaz, Melanie Hanoy, Melanie Marroc, Melodie Cuny, Menno Van Der Straaten, Mf. Serveaux, Michel Basteri, Michel Fen Chong, Michel Hecht, Michel Massad, Michel Normand, Michel Olmer, Michel Tolani, Michel Tsimaratos, Michele Hemery, Michele Kessler, Miguel Esposito, Milad Shenouda, Mimi Kareche, Mina Khalili, Mirella Diaconita, Mohamad Khair Rifard, Mohamed Aladib, Mohamed Belmouaz, Mohamed Brahim, Mohamed Diouani, Mohamed Fodil Cherif, Mohamed Jamali, Mohamed Maghlaoua, Mohamed Meddeb, Mohamed Ramdane, Mohamed Rifaat, Mohamed Sharifull Islam, Mohamed Adnan Abbade, Mokhtar Amrandi, Mokhtar Chawki, Monica Ciobotaru, Monica Indrieis, Monique Chanas, Monique Hoarau, Monzer Tomeh, Moufida Bellou, Mouloud Bouzernidj, Mounia Ammor, Mounir Guergour, Mountassir Benzakour, Mourad Hachicha, Moussa Coulibaly, Mustafa Smati, Mustapha Al Morabiti, Mustapha Amirou, Myriam Isnard, Myriam Pastural, Myriam Pujo, Nourredine Boumendjel, Nabil Majbri, Nabila Goumri, Nadege Mingat, Nader Bassilios, Nadia Kerkeni, Nadia Sedrati, Nadia Soltani, Nadine Maroun, Nadine Neyrat, Nahn Luang, Najeh El Esper, Naji Ammar, Nasredine Ghali, Nasser Hamdini, Natacha Noel, Natacha Potelune, Nathalie Maisonneuve, Nathalie Pertuiset, Nathalie Raynal, Nathalie Vittoz, Nazim Terki, Nelly Castin, Nestor Nankeu, Nicolas Bouvier, Nicolas Keller, Nicolas Legros, Nicolas Peters, Nicolas Quirin, Nicole Lefrancois, Nicole Monnier, Nicole Rance, Niels Bruckmann, Noel Mertens, Nolwenn Lorcy, Olivia Gilbert, Olivier Coldefy, Olivier Drouineau, Olivier Dunand, Olivier Fritz, Olivier Imhoff, Olivier Kourilsky, Olivier Lavelle, Olivier Papin, Olivier Roques, Ophelie Le Maner, Oussamah Fikri Benbrahim, Pablo Antonio Erina Torres, Pablo Antonio Urena Torres, Paolo Malvezzi, Pascal Bindi, Pascal Cluzel, Pascal Fontanier, Pascal Wheatley, Pascale Depraetre, Pascale Dubosq, Pascale Halin, Pascale Sebahoun, Pascale Siohan, Pascale Testevuide, Patrice Deteix, Patrice Nolen, Patricia Hue, Patricia Lemarchand, Patrick Donnadieu, Patrick Fievet, Patrick Fohrer, Patrick Francais, Patrick Giraud, Patrick Hallonet, Patrick Henri, Patrick Michaut, Patrick Niaudet, Patrick Pauly, Patrick Thomas, Patrik Deleaval, Paul Finielz, Paul Stroumza, Paule Hardy Yverneau, Pauline Caillard, Pedro Palacin, Perrine Aubertin, Philippe Attias, Philippe Chauveau, Philippe Coindre, Philippe Coste, Philippe Dubot, Philippe Fournier, Philippe Hiernaux, Philippe Jousset, Philippe Lan Yue Wah, Philippe Lang, Philippe Le Cacheux, Philippe Martin Dupont, Philippe Michel, Philippe Mirgaine, Philippe Moriniere, Philippe Nicoud, Philippe Rieu, Philippe Rousseau, Philippe Sporer, Philippe Thorel, Philippe Vanhille, Philippe Vigeral, Philippe Zaoui, Pierre Bataille, Pierre Brignon, Pierre Filipozzi, Pierre Housset, Pierre Peyronnet, Pierre Ramperez, Pierre Vautrin, Pierre Alexandre Michel, Pierre Francois Westeel, Pierre Louis Carron, Pierre Yves Durand, Pierrot Parent, Piotr Seniuta, François Kuentz, Rabah Fraoui, Rachel Tetaz, Rachid Amaria, Rachid Bourouma, Rachid Djeffal, Rachida Nebbad, Radia Allal, Radu Dimulescu, Rafaat Boustani, Rafik Mesbah, Raifat Makdassi, Raji Diab, Raluca Puslenghea, Raoul Roura, Rateb Khayat, Raymond Azar, Raymond Frayssinet, Regine Monkam, Rehouni Boulahrouz, Remi Boudet, Renato Demontis, Renaud Gansey, Rene Cuvelier, Renee Schmitt, Reschad Noordally, Reynald Binaut, Rezkallah Latif, Richard Dufresne, Richard Montagnac, Richard Reade, Robert Genin, Robert Novo, Rocsana Fickl, Roger Dufresne, Roger Magnol, Roland Issautier, Romain Mortelette, Ronan Delaval, Ronan Lohro, Roseline M'barga, S. Beau, Clémentine Dupuis, Marie Jacques Vidil, Sabria Hacini, Said Dahmoune, Saliha Lekhal, Salima Ahriz Sakso, Salima Saksi, Salvatore Citarda, Samir Boubenider, Samuel Kassis, Sandra Verhille, Sandrine Genestier, Sandrine Muller, Saoussen Krid, Sarah Richter, Sebastien Delbes, Sebastien Mailliez, Sebastien Veillon, Sébastien Nony, Seddick Benarbia, Severine Beaudreuil, Sidi Ali Benyaghla, Simon Duquennoy, Simona Baluta, Simona Boncila, Sonia Mzoughi, Sonia Ribal, Sophie Acamer, Sophie Chauvet, Sophie Girerd, Sophie Ozenne, Sophie Parahy, Sophie Rubens Duval, Sophie Taque, Soraya Menouer, Soumaya Chargui, Stanislas Bataille, Stephane Barbier, Stephane Billion, Stephane Roueff, Stephane Torner, Stephane Jean Martin, Stephanie Coupel, Sylvie Cloarec, Sylvie Lavaud, Sylvie Leou, T. Chatelet, Tania Onesta, Tassadit Benhabib, Tayeb Bensalem, Theodora Dimulescu, Theophile Sawadogo, Thibault Dolley Hitze, Thierry Baranger, Thierry Boudemaghe, Thierry Hannedouche, Thierry Krummel, Thierry Milcent, Thomas Dervaux, Thomas Guincestre, Thomas Kofman, Thomas Raphael, Thomas Sadreux, Tim Ulinski, Tiphaine Guyon Roger, Tomas Serrato, Tomek Kofman, Tony Wong, Toufik Boubia, Ubald Assogba Gbindoun, Usama Khuzaie, Valerie Caudwell, Valerie Chatelet, Valerie Crougneau, Valerie De Precigout, Valerie Drouillat, Valerie Galantine, Valerie Granveau Hugot, Valerie Leroy, Veronique Boubia, Veronique Falque, Veronique Fournier, Veronique Queron, Veronique Viviani, Victor Gueuttin, Victor Panescu, Victorio Menoyo Calonge, Viet Nguyen, Vincent Allot, Vincent Delattre, Vincent Leduc, Vincent Pradier, Violaine Emal Aglae, Viorica Badulescu, Virginia Molina, Virginie Besson, Virginie Chaigne, Waddah Jaber, Wael Boudi, Wael El Haggan, Wen Qin Guillon, Wided Tabbi Aneni, William Hanf, Wladimir Kohn, Xavier Bellenfant, Xavier Moreau Gaudry, Yahsou Delmas, Yannick Knefati, Yannick Saingra, Yannick Tirolien, Youssef Mann, Yvan Brunak, Yves Dimitrov, Yves Doussy, Yves Tanter, Zaid Benabid, Zaara Soltani, Zacharia Boukerroucha, Zafer Takla, Zana Ramanantsialonina, Zara Dickson, Zead Tubail, Zoe Koochaki Pour, Zohra Boukhalfa, Zohra Jacquot, Agence de la biomédecine [Saint-Denis la Plaine], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Université de Caen Normandie (UNICAEN), Normandie Université (NU), CALYDIAL Vienne, Partenaires INRAE, Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Armand Trousseau [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de néphrologie et transplantation rénale [Hôpital de la Conception - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Service d'Epidémiologie et Evaluations Cliniques [CHRU Nancy] (Pôle S2R), Centre Universitaire des Maladies Rénales [CHU Caen] (CUMR Caen), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Groupe hospitalier de la région de Mulhouse Sud-Alsace (GHRMSA), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Assistance Publique - Hôpitaux de Marseille (APHM), Service de diabétologie [CHU Pitié-Salpétrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Service de Diabétologie [CHU Pitié-Salpétrière], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Subjects: 0301 basic medicine, Male, medicine.medical_treatment, [SDV]Life Sciences [q-bio], 030232 urology & nephrology, Hemodialysis, Home, Disease, MESH: COVID-19 / therapy, registry, Ambulatory Care Facilities, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, MESH: Aged, 80 and over, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Risk Factors, 80 and over, Prevalence, covid, dialysis, epidemiology, mortality, Aged, Aged, 80 and over, COVID-19, Case-Control Studies, Critical Care, Female, France, Humans, Incidence, Middle Aged, Patient Acuity, Protective Factors, Registries, Renal Dialysis, SARS-CoV-2, Sex Factors, Hypoalbuminemia, MESH: France / epidemiology, education.field_of_study, Incidence (epidemiology), 3. Good health, MESH: COVID-19 / epidemiology, Nephrology, Hemodialysis, medicine.medical_specialty, Population, Lower risk, Article, 03 medical and health sciences, MESH: Sex Factors, Internal medicine, medicine, MESH: SARS-CoV-2, MESH: Renal Dialysis / statistics & numerical data, education, Dialysis, Vascular disease, business.industry, medicine.disease, Former Smoker, MESH: Critical Care / statistics & numerical data, 030104 developmental biology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Home, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, MESH: Hemodialysis, Home / statistics & numerical data
Abstract: The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2. A total of 1,621 infected patients were reported on the REIN registry from March 16th, 2020 to May 4th, 2020. Of these, 344 died. The prevalence of COVID-19 patients varied from less than 1% to 10% between regions. The probability of being a case was higher in males, patients with diabetes, those in need of assistance for transfer or treated at a self-care unit. Dialysis at home was associated with a lower probability of being infected as was being a smoker, a former smoker, having an active malignancy, or peripheral vascular disease. Mortality in diagnosed cases (21%) was associated with the same causes as in the general population. Higher age, hypoalbuminemia and the presence of an ischemic heart disease were statistically independently associated with a higher risk of death. Being treated at a selfcare unit was associated with a lower risk. Thus, our study showed a relatively low frequency of COVID-19 among dialysis patients contrary to what might have been assumed., Graphical abstract
Published: 2020

38. Is Urinary Chromium Specific to Hexavalent Chromium Exposure in the Presence of Co-exposure to Other Chromium Compounds? A Biomonitoring Study in the Electroplating Industry

Author: Pascal Wild, Nadège Jacoby, Aurélie Remy, and Alain Robert
Subjects: Chromium, Chromium Compounds, chemistry.chemical_element, Context (language use), 010501 environmental sciences, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Occupational Exposure, Biomonitoring, Humans, Occupational exposure limit, Hexavalent chromium, Electroplating, 0105 earth and related environmental sciences, Chemistry, Public Health, Environmental and Occupational Health, Bayes Theorem, 030210 environmental & occupational health, Environmental chemistry, Chromic acid, Biological Monitoring, Environmental Monitoring
Abstract: Objectives Electroplating processes are widely used in metal industries to improve the resistance properties of manufactured metal parts. Workers in this industry are potentially exposed both to hexavalent chromium (Cr(VI)) and to other chromium compounds [mostly trivalent chromium (Cr(III))], due to the use of chromic acid baths. The goal of this study was to validate urinary chromium as a Cr(VI) exposure biomarker in the presence of exposure to other chromium compounds. Methods A biomonitoring study consisted in monitoring airborne chromium exposure and urinary chromium for one working week in 93 workers from nine electroplating companies. Chromium concentrations were measured in all urinations of each volunteer for the working week. Individual airborne soluble and insoluble Cr(VI) as well as Cr(III) concentrations were measured for all of the shifts of the week. The main statistical analysis consisted in modelling, in a Bayesian framework, the pre- and post-shift urinary chromium as a function of airborne Cr(III) and airborne Cr(VI), taking into account the day of the week and the time of collection of the urines (pre- or post-shift). Results Preliminary descriptions showed an increase in pre-shift urinary chromium during the working week. The model showed an increase in urinary chromium over the shift related to the shift-specific airborne Cr(VI) concentration as well as an increasing trend over the week and a relationship with the mean weekly Cr(VI) thought to reflect chronic exposure. Taking into account the Cr(VI) exposure, there was no evidence of an effect of Cr(III) exposure on urinary chromium. A biological limit value (BLV) was derived from the French occupational exposure limit for Cr(VI) of 1 µg m−3 and was estimated at between 1.9 and 2.6 µg g−1 creatinine for a urinary sample collected at the end of the shift on the last working day of the week. Conclusions In the present context of mixed exposure to Cr(III) and Cr(VI) in electroplating, this study showed that urinary chromium depended only on airborne Cr(VI) concentrations, which justifies using a BLV for assessing workers’ exposure. The estimated BLV was close to the recommended French BLV, which is 1.8 µg g−1 creatinine, in the electroplating industry.
Published: 2020

39. A technical soda lignin as sole carbon-diet for a higher termite species, Nasutitermes ephratae: insight into the changes in the gut bacterial community and in the lignin phenolic fraction

Author: Stéphanie Baumberger, Laurent Cézard, Catherine Lapierre, My Dung Jusselme, Florian Pion, Philippe Mora, Alain Robert, Michel Diouf, and Edouard Miambi
Subjects: chemistry.chemical_compound, Carbon diet, chemistry, Nasutitermes ephratae, Lignin, Fraction (chemistry), Food science
Abstract: BackgroundTermites account for natural biomass utilization systems (NBUS) that evolved the ability to overcome the overall recalcitrance of lignins towards lignocellulose transformation processes. With the objective of applying this capacity to the conversion of technical lignins produced by biorefineries, a higher wood-feeding termite species, Nasutitermes ephratae was fed with a commercial grass soda lignin (Protobind 1000, PB1000). The survival rates of Protobind 1000-fed termites were determined as well as changes in the structure of gut bacterial community and in the chemical composition of this technical lignin. ResultsThe ingestion of PB1000 by worker castes of N. ephratae was revealed by Pyrolysis-Gas Chromatography Mass Spectrometry (Py-GC/MS) analyses directly performed on termites. Survival rates were reduced by two –fold in the termites fed with PB1000 compared to controls. The relative abundance of Firmicutes and Bacteroidetes increased in the gut bacterial community of termites fed with PB1000. The digestion of PB1000 by termites triggered an increase in the syringyl-to-guaiacyl (S/G) ratios. These changes in the chemical composition of PB1000 in the gut of termites was marked by a decrease in relative content of free phenolic monomers.ConclusionThis work showed the abilities of digestive tract of a wood-feeding higher termite species, N. ephratae to metabolize the fraction of the volatile phenolic monomers of PB1000. Overall, our results provide insights into the bacterial lineage candidates for development of bacterial inoculum for pretreatment processes in valorization of technical lignin in biorefinery.
Published: 2020

40. Functional analysis and NSA

Author: Alain Robert
Subjects: Computer science, Computational biology, Functional analysis (psychology)
Published: 2020

41. Trail-Following Pheromones in the Termite Subfamily Syntermitinae (Blattodea, Termitoidae, Termitidae)

Author: David Sillam-Dussès, Ping Wen, Etienne Sémon, Eliana M. Cancello, Alain Robert, Jan Šobotník, Michael J. Lacey, Christian Bordereau, Chloé Leroy, Thomas Bourguignon, Laboratory of Experimental and Comparative Ethology, Université Paris 13 (UP13), Czech University of Life Sciences Prague (CZU), Department of Forest Ecology, Faculty of Forestry and Wood Sciences, Okinawa Institute of Science and Technology Graduate University, Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences [Changchun Branch] (CAS), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris ), Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Museu de Zoologia (MZ), Universidade de São Paulo (USP), Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), project of Internal Grant Agency of Faculty of Tropical AgriSciences 20195006, National Council for Scientific and Technological Development (CNPq)3076681/2016-5\0, Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Universidade de São Paulo = University of São Paulo (USP)
Subjects: 0106 biological sciences, dodecatrienol, Entomology, Subfamily, Pheromone parsimony, dodecadienol, Dodecatrienol, Foraging, Zoology, Isoptera, 01 natural sciences, Biochemistry, Pheromones, termitidae, Blattodea, Termite, pheromone parsimony, Dodecadienol, Animals, Termitidae, Ecology, Evolution, Behavior and Systematics, [SDV.EE]Life Sciences [q-bio]/Ecology, environment, biology, General Medicine, biology.organism_classification, 010602 entomology, Sex pheromone, neocembrene, Key (lock), Pheromone, termite, Neocembrene, 010606 plant biology & botany
Abstract: International audience; Trail-following behavior is a key to ecological success of termites, allowing them to orient themselves between the nesting and foraging sites. This behavior is controlled by specific trail-following pheromones produced by the abdominal sternal gland occurring in all termite species and developmental stages. Trail-following communication has been studied in a broad spectrum of species, but the “higher” termites (i.e. Termitidae) from the subfamily Syntermitinae remain surprisingly neglected. To fill this gap, we studied the trail-following pheromone in six genera and nine species of Syntermitinae. Our chemical and behavioral experiments showed that (3Z,6Z,8E)-dodeca-3,6,8-trien-1-ol is the single component of the pheromone of all the termite species studied, except for Silvestritermes euamignathus. This species produces both (3Z,6Z)-dodeca-3,6-dien-1-ol and neocembrene, but only (3Z,6Z)-dodeca-3,6-dien-1-ol elicits trail-following behavior. Our results indicate the importance of (3Z,6Z,8E)-dodeca-3,6,8-trien-1-ol, the most widespread communication compound in termites, but also the repeated switches to other common pheromones as exemplified by S. euamignathus.
Published: 2020

42. MICROSCOPE instrument description and validation

Author: Stefanie Bremer, Ratana Chhun, Meike List, Bruno Christophe, Gilles Métris, Hanns Selig, Pascale Danto, Alain Robert, Yves André, Damien Boulanger, Pierre Touboul, Vincent Lebat, Frank Löffler, Joel Bergé, Manuel Rodrigues, Daniel Hagedorn, Benny Rievers, Phuong-Anh Huynh, Emilie Hardy, Françoise Liorzou, Bernard Foulon, Claus Laemmerzahl, DPHY, ONERA, Université Paris Saclay [Châtillon], ONERA-Université Paris-Saclay, Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), and Centre National d'Études Spatiales [Toulouse] (CNES)
Subjects: microsatellite, General Relativity, noise, Physics - Instrumentation and Detectors, accelerometers, inertial sensor, Microscope, Physics and Astronomy (miscellaneous), Capacitive sensing, satellite, Micro-satellite, electrostatic actuators, Mechanical engineering, FOS: Physical sciences, Space accelerometers, General Relativity and Quantum Cosmology (gr-qc), space mission, Accelerometer, 01 natural sciences, General Relativity and Quantum Cosmology, law.invention, Acceleration, law, 0103 physical sciences, Digital control, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Electronics, force: electrostatic, 010306 general physics, Experimental Gravitation, Instrumentation and Methods for Astrophysics (astro-ph.IM), detector: design, Equivalence Principle, Physics, capacitive sensing, 010308 nuclear & particles physics, gravitation test, Instrumentation and Detectors (physics.ins-det), Noise, capacitive sensors, detector: acceleration, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], control system, Astrophysics - Instrumentation and Methods for Astrophysics, performance, Position sensor, electronics: design
Abstract: Dedicated accelerometers have been developed for the MICROSCOPE mission taking into account the specific range of acceleration to be measured on board the satellite. Considering one micro-g and even less as the full range of the instrument, leads to a customized concept and a high performance electronics for the sensing and servo-actuations of the accelerometer test-masses. In addition to a very accurate geometrical sensor core, a high performance electronics architecture provides the measurement of the weak electrostatic forces and torques applied to the test-masses. A set of capacitive sensors delivers the position and the attitude of the test-mass with respect to a very steady gold coated cage made in silica. The voltages applied on the electrodes surrounding each test-mass are finely controlled to generate the adequate electrical field and so the electrostatic pressures on the test-mass. This field maintains the test-mass motionless with respect to the instrument structure. Digital control laws are implemented in order to enable instrument operation flexibility and a weak position sensor noise. These electronics provide both the scientific data for MICROSCOPE's test of General Relativity and the data for the satellite drag-free and attitude control system (DFACS)., Comment: To be submitted to CQG's MICROSCOPE special issue
Published: 2020
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43. Recent biomonitoring reports on phosphate ester flame retardants: a short review

Author: Alain Robert, Anne-Marie Saillenfait, Jean-Philippe Sabaté, Sophie Ndaw, and Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) (INRS ( Vandoeuvre lès Nancy))
Subjects: RETARDATEUR DE FLAMME, REVUE DE LA LITTERATURE, Health, Toxicology and Mutagenesis, Pharmacology toxicology, Population, 010501 environmental sciences, Toxicology, Risk Assessment, 01 natural sciences, Electronic equipment, Flame retardant, Occupational Exposure, Biomonitoring, URINE, Humans, SURVEILLANCE BIOLOGIQUE, education, Flame Retardants, 0105 earth and related environmental sciences, Exposure assessment, DOSAGE, education.field_of_study, TOXICITE, 010401 analytical chemistry, Environmental Exposure, General Medicine, PRODUIT CHIMIQUE, IGNIFUGATION, ORGANOPHOSPHORE, Organophosphates, respiratory tract diseases, 0104 chemical sciences, Human biomonitoring, Health, METABOLISME, Human exposure, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Environmental chemistry, EVALUATION DE L'EXPOSITION, Environmental science, Biomarkers, Fire retardant
Abstract: International audience; Organophosphate triesters (PEFRs) are used increasingly as flame retardants and plasticizers in a variety of applications, such as building materials, textiles, and electric and electronic equipment. They have been proposed as alternatives to brominated flame retardants. This updated review shows that biomonitoring has gained incrementally greater importance in evaluating human exposure to PEFRs, and it holds the advantage of taking into account the multiple potential sources and various intake pathways of PEFRs. Simultaneous and extensive internal exposure to a broad range of PEFRs has been reported worldwide. Their metabolites, mainly dialkyl or diaryl diesters, have been used as biomarkers of exposure and have been ubiquitously detected in the urine of adults and children in the general population. Concentrations and profiles of PEFR urinary metabolites are seen to be variable and are highly dependent on individual and environmental factors, including age, country regulation of flame retardants, and types and quantities of emissions in microenvironments, as well as analytical procedures. Additional large biomonitoring studies, using a broad range of urinary diesters and hydroxylated metabolites, would be useful to improve the validity of the biomarkers and to refine assessments of human exposure to PEFRs.; Les triesters organophosphorés (RFOPs) sont de plus en plus utilisés comme retardateurs de flamme et comme plastifiants dans de nombreuses applications, tels que les matériaux de construction, les textiles et les équipements électriques et électroniques. Ils sont proposés comme alternatives aux retardateurs de flamme bromés. Cette synthèse actualisée des données bibliographiques montre que la surveillance biologique a progressivement acquis une plus grande importance dans l’évaluation de l’exposition humaine aux RFOPs. Elle a comme avantage de prendre en compte les multiples sources potentielles et les différentes voies d’absorption des RFOPs. Ces études montrent une exposition interne répandue et simultanée à un large éventail de RFOPs, dans le monde entier. Les métabolites des RFOPs, principalement des diesters dialkyl ou diaryl, ont été utilisés comme biomarqueurs d’exposition et ils ont été détectés de façon ubiquitaire dans l’urine des adultes et enfants de la population générale. Les concentrations et les profils des métabolites urinaires sont variables. Ils sont fortement influencés par des facteurs individuels et environnementaux, notamment l’âge, la réglementation du pays de retardateurs de flamme et les types et les quantités des émissions de RFOPs à partir des micro-environnements, ainsi que par les méthodes d’analyse. Quelques études de biométrologie urinaire ont mis en évidence des expositions professionnelles aux RFOPs. Des études de biosurveillance à grande échelle utilisant un large éventail de diesters et métabolites hydroxylés urinaires seraient utiles pour optimiser le choix des biomarqueurs et affiner l’évaluation de l’exposition humaine aux RFOPs.
Published: 2018

44. MICROSCOPE mission: drag-free and attitude control system expertise activities toward the scientific team

Author: Pascal Prieur, Thomas Lienart, Pierre-Yves Guidotti, Alain Robert, and Stéphanie Delavault
Subjects: 010309 optics, Ancillary data, Flexibility (engineering), Attitude control system, Space and Planetary Science, Computer science, 0103 physical sciences, Systems engineering, Aerospace Engineering, 01 natural sciences, Gas monitoring, 010305 fluids & plasmas
Abstract: Microscope is a CNES-ESA-ONERA-CNRS-OCA-DLR-ZARM mission dedicated to the test of the Equivalence Principle with an improved accuracy of 10−15. The 300 kg drag-free microsatellite was launched on April 25th 2016 into a 710 km dawndusk sun-synchronous orbit for a 2-year mission. To comply with stringent requirements, the drag-free and attitude control system (DFACS) involves the scientific accelerometer as main sensor and a set of 8 cold gas proportional thrusters. Once in mission mode, within the CNES drag-free expertise center (CECT) the DFACS team provides several services to the system and to the scientific mission center: cold gas monitoring and management, ‘Attitude’ ancillary data, DFACS expertise ancillary data. For this purpose, expertise tools have been implemented in the CECT, using the flexibility and efficiency of Matlab™ utilities. This paper presents the role of the CECT within the mission and details the expertise activities of the DFACS team illustrated with some typical in flight results.
Published: 2018

45. L'incidence de la Charte canadienne des droits et libertes sur les droits linguistiques quebecois.

Author: Nadeau, Alain-Robert
Subjects: Linguistic minorities -- Laws, regulations and rules, Language policy -- Laws, regulations and rules, Government regulation, Canada. Constitution Act 1982 (Can. Const. pt. 1), Quebec. Charter of the French Language
Published: 2006

46. Evaluation of the effects of α-cypermethrin on fetal rat testicular steroidogenesis

Author: Alain Robert, Dieynaba Ndiaye, Alain-Claude Roudot, Flavien Denis, Guillaume Antoine, Ethel Eljarrat, Jean-Philippe Sabaté, and Anne-Marie Saillenfait
Subjects: Male, 0301 basic medicine, Litter (animal), Insecticides, medicine.medical_specialty, 010501 environmental sciences, Toxicology, 01 natural sciences, Rats, Sprague-Dawley, 03 medical and health sciences, Fetus, Pregnancy, Internal medicine, Pyrethrins, Testis, medicine, Animals, Testosterone, Maternal-Fetal Exchange, 0105 earth and related environmental sciences, biology, Cholesterol side-chain cleavage enzyme, Body Weight, Anogenital distance, Neurotoxicity, Gene Expression Regulation, Developmental, medicine.disease, Dibutyl Phthalate, 030104 developmental biology, Endocrinology, HMG-CoA reductase, biology.protein, Gestation, Female
Abstract: Pregnant Sprague-Dawley rats were administered the insecticide α-cypermethrin at doses of 0.1, 1, 5, or 10mg/kg/day, or di-isobutyl phthalate (DIBP) at 250mg/kg/day, by gavage, from gestation day (GD) 13 to 19. Testicular testosterone production and the expression of several key genes related to cholesterol and androgen synthesis and transport were assessed in GD 19 male fetuses. Dams treated with 10mg/kg/day of α-cypermethrin showed clinical signs of neurotoxicity and reduced body weight gain. α-Cypermethrin had no significant effect on post-implantation loss, fetal weight, incidence of male fetuses per litter, or anogenital distance of the male fetuses. In the fetal testes, mRNA expressions of HMG-CoA synthase and reductase, SRB1, StAR, P450scc, 3βHSD, P450 17A1, and 17βHSD were not affected by exposure to α-cypermethrin. Testosterone production by the fetal testis was significantly reduced at 5 and 10mg/kg/day of α-cypermethrin, although to a much smaller extent than in DIBP-exposed fetuses.
Published: 2017

47. Space test of the Equivalence Principle: first results of the MICROSCOPE mission

Author: Pierre Touboul, Stefanie Bremer, Alain Robert, Ratana Chhun, Valerio Cipolla, Meike List, Benjamin Pouilloux, Thibault Damour, Damien Boulanger, Isabelle Panet, Yves André, Vincent Lebat, T. J. Sumner, Manuel Rodrigues, Bruno Christophe, Bernard Foulon, Pierre-Yves Guidotti, Pascale Danto, Hanns Selig, Laura Serron, Pascal Prieur, Françoise Liorzou, Gilles Metris, Emilie Hardy, Joel Bergé, Hansjoerg Dittus, Pieter Visser, Sandrine Pires, Claus Lämmerzahl, Benny Rievers, Phuong-Anh Huynh, Pierre Fayet, Serge Reynaud, Quentin Baghi, DPHY, ONERA, Université Paris Saclay (COmUE) [Châtillon], ONERA-Université Paris Saclay (COmUE), DPHY, ONERA, Université Paris Saclay (COmUE) [Palaiseau], Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Centre National de la Recherche Scientifique (CNRS), DAAA, ONERA, Université Paris-Saclay (COmUE) [Châtillon], Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France, Center of Applied Space Technology and Microgravity (ZARM), Universität Bremen, Centre National d'Études Spatiales [Toulouse] (CNES), Institut des Hautes Études Scientifiques (IHES), IHES, Deutsches Zentrum für Luft- und Raumfahrt [Köln] (DLR), Laboratoire de Physique Théorique de l'ENS [École Normale Supérieure] (LPTENS), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Champs, Gravitation et Cordes, Laboratoire de physique de l'ENS - ENS Paris (LPENS (UMR_8023)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique du Globe de Paris (IPGP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS), École nationale des sciences géographiques (ENSG), Institut National de l'Information Géographique et Forestière [IGN] (IGN), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Kastler Brossel (LKB (Jussieu)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Blackett Laboratory, Imperial College London, Delft University of Technology (TU Delft), DPHY, ONERA, Université Paris Saclay [Châtillon], ONERA-Université Paris-Saclay, DPHY, ONERA, Université Paris Saclay [Palaiseau], Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), DAAA, ONERA, Université Paris-Saclay [Châtillon], Université Fédérale Toulouse Midi-Pyrénées, ZARM, University of Bremen, Institut des Hautes Etudes Scientifiques (IHES), Laboratoire de Physique Théorique de l'ENS (LPTENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Université Pierre et Marie Curie - Paris 6 (UPMC)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Université Paris Diderot - Paris 7 (UPD7)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Université de La Réunion (UR)-Université Paris Diderot - Paris 7 (UPD7)-IPG PARIS-Institut national des sciences de l'Univers (INSU - CNRS), and Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)
Subjects: General Relativity, Physics and Astronomy (miscellaneous), General relativity, Physics, Multidisciplinary, REDSHIFT, MICROSATELLITE, FOS: Physical sciences, Space accelerometers, General Relativity and Quantum Cosmology (gr-qc), Astronomy & Astrophysics, RELATIVITE GENERALE, 01 natural sciences, Weak equivalence, General Relativity and Quantum Cosmology, Physics, Particles & Fields, Gravitation, Theory of relativity, Quadratic equation, Gravitational field, GRAVITY, Physics - Space Physics, 0103 physical sciences, ACCELEROMETERS, Equivalence principle, GENERAL-RELATIVITY, 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Experimental Gravitation, MICROSCOPE, 01 Mathematical Sciences, Mathematical physics, Physics, Equivalence Principle, Science & Technology, drag-free, 02 Physical Sciences, 010308 nuclear & particles physics, Quantum Science & Technology, PRINCIPE EQUIVALENCE, GRAVITATION, Nuclear & Particles Physics, Space Physics (physics.space-ph), ACCELEROMETRE ELECTROSTATIQUE ULTRASENSIBLE, Physical Sciences, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], COMPENSATION TRAINEE, Astrophysics - Instrumentation and Methods for Astrophysics, Order of magnitude
Abstract: The Weak Equivalence Principle (WEP), stating that two bodies of different compositions and/or mass fall at the same rate in a gravitational field (universality of free fall), is at the very foundation of General Relativity. The MICROSCOPE mission aims to test its validity to a precision of $10^{-15}$, two orders of magnitude better than current on-ground tests, by using two masses of different compositions (titanium and platinum alloys) on a quasi-circular trajectory around the Earth. This is realised by measuring the accelerations inferred from the forces required to maintain the two masses exactly in the same orbit. Any significant difference between the measured accelerations, occurring at a defined frequency, would correspond to the detection of a violation of the WEP, or to the discovery of a tiny new type of force added to gravity. MICROSCOPE's first results show no hint for such a difference, expressed in terms of E\"otv\"os parameter $\delta(Ti,Pt)=[-1\pm{}9{\rm (stat)}\pm{}9{\rm (syst)}] \times{}10^{-15}$ (both 1$\sigma$ uncertainties) for a titanium and platinum pair of materials. This result was obtained on a session with 120 orbital revolutions representing 7\% of the current available data acquired during the whole mission. The quadratic combination of 1$\sigma$ uncertainties leads to a current limit on $\delta$ of about $1.3\times{}10^{-14}$., Comment: To appear in CQG
Published: 2019

48. Efficacy of the Antibody-Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors

Author: Nicolas Boute, Mariya Pavlyuk, Matthieu Broussas, Barbara Akla, Cyrille Dreyfus, Michel Perez, Charlotte Beau-Larvor, Thierry Champion, Alain Robert, Eric Chetaille, Alain Beck, Noureddine Loukili, Martine Malissard, Jean-François Haeuw, and Nathalie Corvaia
Subjects: 0301 basic medicine, Cancer Research, Antibody-drug conjugate, Immunoconjugates, media_common.quotation_subject, medicine.medical_treatment, Mice, Nude, medicine.disease_cause, Receptor, IGF Type 1, 03 medical and health sciences, Mice, 0302 clinical medicine, Cell Line, Tumor, Neoplasms, medicine, Cytotoxic T cell, Animals, Humans, Internalization, Receptor, media_common, biology, Chemistry, Growth factor, Insulin receptor, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Female, Carcinogenesis, Tyrosine kinase
Abstract: The insulin-like growth factor type 1 receptor (IGF-1R) is important in tumorigenesis, and its overexpression occurs in numerous tumor tissues. To date, therapeutic approaches based on mAbs and tyrosine kinase inhibitors targeting IGF-1R have only shown clinical benefit in specific patient populations. We report a unique IGF-1R–targeted antibody–drug conjugate (ADC), W0101, designed to deliver a highly potent cytotoxic auristatin derivative selectively to IGF-1R overexpressing tumor cells. The mAb (hz208F2-4) used to prepare the ADC was selected for its specific binding properties to IGF-1R compared with the insulin receptor, and for its internalization properties. Conjugation of a novel auristatin derivative drug linker to hz208F2-4 did not alter its binding and internalization properties. W0101 induced receptor-dependent cell cytotoxicity in vitro when applied to various cell lines overexpressing IGF-1R, but it did not affect normal cells. Efficacy studies were conducted in several mouse models expressing different levels of IGF-1R to determine the sensitivity of the tumors to W0101. W0101 induced potent tumor regression in certain mouse models. Interestingly, the potency of W0101 correlated with the expression level of IGF-1R evaluated by IHC. In an MCF-7 breast cancer model with high-level IGF-1R expression, a single injection of W0101 3 mg/kg led to strong inhibition of tumor growth. W0101 provides a potential new therapeutic option for patients overexpressing IGF-1R. A first-in-human trial of W0101 is currently ongoing to address clinical safety.
Published: 2019

49. Early Effect Markers and Exposure Determinants of Metalworking Fluids Among Metal Industry Workers: Protocol for a Field Study

Author: Eve Bourgkard, Jean-Louis Edmé, Nancy B. Hopf, Yves Guichard, Pascal Wild, Nathalie Chérot-Kornobis, Valérie Demange, Sébastien Hulo, Fanny Jeandel, Jean-Jacques Sauvain, Alain Robert, Ronan Levilly, and Jacques A. Pralong
Subjects: Physiology, early effect biomarkers, Urine, medicine.disease_cause, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, exposure biomarkers, medicine, Protocol, oxidative stress, Exhaled breath condensate, Respiratory system, 030304 developmental biology, Exposure assessment, 0303 health sciences, business.industry, General Medicine, Malondialdehyde, 030210 environmental & occupational health, occupational epidemiology, chemistry, Exhaled nitric oxide, Micronucleus, business, genotoxic effects, metalworking fluid, Oxidative stress
Abstract: Background Exposure to aerosols from metalworking fluids (MWF) has previously been related to a series of adverse health outcomes (eg, cancer, respiratory diseases). Our present epidemiological study focuses on occupational exposures to MWF and a panel of exposure and effect biomarkers. We hypothesize that these health outcomes are caused by particle exposure that generates oxidative stress, leading to airway inflammation and ultimately to chronic respiratory diseases. We aimed to assess whether MWF exposure, in particular as characterized by its oxidative potential, is associated with biomarkers of oxidative stress and inflammation as well as genotoxic effects. Objective The ultimate goal is to develop exposure reduction strategies based on exposure determinants that best predict MWF-related health outcomes. The following relationships will be explored: (1) exposure determinants and measured exposure; (2) occupational exposure and preclinical and clinical effect markers; (3) exposure biomarkers and biomarkers of effect in both exhaled breath condensate and urine; and (4) biomarkers of effect, genotoxic effects and respiratory symptoms. Methods At least 90 workers from France and Switzerland (30 controls, 30 exposed to straight MWF and 30 to aqueous MWF) were followed over three consecutive days after a nonexposed period of at least two days. The exposure assessment is based on MWF, metal, aldehyde, and ultrafine particle number concentrations, as well as the intrinsic oxidative potential of aerosols. Furthermore, exposure biomarkers such as metals, metabolites of polycyclic aromatic hydrocarbons and nitrosamine are measured in exhaled breath condensate and urine. Oxidative stress biomarkers (malondialdehyde, 8-isoprostane, 8-hydroxy-2’-deoxyguanosine, nitrates, and nitrites) and exhaled nitric oxide, an airway inflammation marker, are repeatedly measured in exhaled breath condensate and urine. Genotoxic effects are assessed using the buccal micronucleus cytome assay. The statistical analyses will include modelling exposure as a function of exposure determinants, modelling the evolution of the biomarkers of exposure and effect as a function of the measured exposure, and modelling respiratory symptoms and genotoxic effects as a function of the assessed long-term exposure. Results Data collection, which occurred from January 2018 until June 2019, included 20 companies. At the date of writing, the study included 100 subjects and 29 nonoccupationally exposed controls. Conclusions This study is unique as it comprises human biological samples, questionnaires, and MWF exposure measurement. The biomarkers collected in our study are all noninvasive and are useful in monitoring MWF exposed workers. The aim is to develop preventative strategies based on exposure determinants related to health outcomes. International Registered Report Identifier (IRRID) DERR1-10.2196/13744
Published: 2019

50. Early Effect Markers and Exposure Determinants of Metalworking Fluids Among Metal Industry Workers: Protocol for a Field Study (Preprint)

Author: Nancy B Hopf, Eve Bourgkard, Valérie Demange, Sébastien Hulo, Jean-Jacques Sauvain, Ronan Levilly, Fanny Jeandel, Alain Robert, Yves Guichard, Jacques André Pralong, Nathalie Chérot-Kornobis, Jean-Louis Edmé, and Pascal Wild
Abstract: BACKGROUND Exposure to aerosols from metalworking fluids (MWF) has previously been related to a series of adverse health outcomes (eg, cancer, respiratory diseases). Our present epidemiological study focuses on occupational exposures to MWF and a panel of exposure and effect biomarkers. We hypothesize that these health outcomes are caused by particle exposure that generates oxidative stress, leading to airway inflammation and ultimately to chronic respiratory diseases. We aimed to assess whether MWF exposure, in particular as characterized by its oxidative potential, is associated with biomarkers of oxidative stress and inflammation as well as genotoxic effects. OBJECTIVE The ultimate goal is to develop exposure reduction strategies based on exposure determinants that best predict MWF-related health outcomes. The following relationships will be explored: (1) exposure determinants and measured exposure; (2) occupational exposure and preclinical and clinical effect markers; (3) exposure biomarkers and biomarkers of effect in both exhaled breath condensate and urine; and (4) biomarkers of effect, genotoxic effects and respiratory symptoms. METHODS At least 90 workers from France and Switzerland (30 controls, 30 exposed to straight MWF and 30 to aqueous MWF) were followed over three consecutive days after a nonexposed period of at least two days. The exposure assessment is based on MWF, metal, aldehyde, and ultrafine particle number concentrations, as well as the intrinsic oxidative potential of aerosols. Furthermore, exposure biomarkers such as metals, metabolites of polycyclic aromatic hydrocarbons and nitrosamine are measured in exhaled breath condensate and urine. Oxidative stress biomarkers (malondialdehyde, 8-isoprostane, 8-hydroxy-2’-deoxyguanosine, nitrates, and nitrites) and exhaled nitric oxide, an airway inflammation marker, are repeatedly measured in exhaled breath condensate and urine. Genotoxic effects are assessed using the buccal micronucleus cytome assay. The statistical analyses will include modelling exposure as a function of exposure determinants, modelling the evolution of the biomarkers of exposure and effect as a function of the measured exposure, and modelling respiratory symptoms and genotoxic effects as a function of the assessed long-term exposure. RESULTS Data collection, which occurred from January 2018 until June 2019, included 20 companies. At the date of writing, the study included 100 subjects and 29 nonoccupationally exposed controls. CONCLUSIONS This study is unique as it comprises human biological samples, questionnaires, and MWF exposure measurement. The biomarkers collected in our study are all noninvasive and are useful in monitoring MWF exposed workers. The aim is to develop preventative strategies based on exposure determinants related to health outcomes. INTERNATIONAL REGISTERED REPOR DERR1-10.2196/13744
Published: 2019

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