Table S1, Table S2, Table S3, Table S4, Figure S1Figure S2, Figure S3, Figure S4, Figure S5, Figure S6, Figure S7 from Efficacy of the Antibody–Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors

Table S1 shows expression of IGF1R on human tissues Table S2 shows expression of IGF1R on Tumor and Normal cells Table S3 shows DAR calculation Table S4 shows impact of W0101 on cell cycle Figure S1 shows the flowchart for selection of m208F2 Figure S2 shows kinetics of internalization of murine anti-IGF1R antibodies Figure S3 shows inhibition of binding and phosphorylation of IGF-1R Figure S4 shows binding and internalisation of W0101 on MCF7 cells Figure S5 shows impact of W0101 on apoptose compared to MMAE and isotype control ADC Figure S6 shows in vivo activity of naked antibody on MCF7 and NCI-H2122 models Figure S7 demonstrated the absence of bystander effect of W0101