171 results on '"Alagna, Laura"'
Search Results
2. Severity of SARS-CoV-2 infection in a hospital population: a clinical comparison across age groups
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Rosazza, Chiara, Alagna, Laura, Bandera, Alessandra, Biffi, Arianna, Ciciriello, Fabiana, Gramegna, Andrea, Lucidi, Vincenzina, Marchisio, Paola Giovanna, Medino, Paola, Muscatiello, Antonio, Uceda Renteria, Sara, and Colombo, Carla
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- 2023
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3. Incidence, microbiological and immunological characteristics of ventilator-associated pneumonia assessed by bronchoalveolar lavage and endotracheal aspirate in a prospective cohort of COVID-19 patients: CoV-AP study
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Mangioni, Davide, Panigada, Mauro, Palomba, Emanuele, Bobbio, Chiara, Chatenoud, Liliane, Alagna, Laura, Fumagalli, Jacopo, Gori, Andrea, Grancini, Anna, Guzzardella, Amedeo, Lombardi, Andrea, Matinato, Caterina, Meli, Andrea, Muscatello, Antonio, Porretti, Laura, Tomasello, Mara, Trombetta, Elena, Valenti, Luca, Bandera, Alessandra, and Grasselli, Giacomo
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- 2023
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4. Changes in upper airways microbiota in ventilator-associated pneumonia
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Alagna, Laura, Mancabelli, Leonardo, Magni, Federico, Chatenoud, Liliane, Bassi, Gabriele, Del Bianco, Silvia, Fumagalli, Roberto, Turroni, Francesca, Mangioni, Davide, Migliorino, Guglielmo M., Milani, Christian, Muscatello, Antonio, Nattino, Giovanni, Picetti, Edoardo, Pinciroli, Riccardo, Rossi, Sandra, Tonetti, Tommaso, Vargiolu, Alessia, Bandera, Alessandra, Ventura, Marco, Citerio, Giuseppe, and Gori, Andrea
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- 2023
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5. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy
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Bosari, Silvano, Scudeller, Luigia, Fusetti, Giuliana, Rusconi, Laura, Dell’Orto, Silvia, Prati, Daniele, Valenti, Luca, Giovannelli, Silvia, Manunta, Maria, Lamorte, Giuseppe, Ferarri, Francesca, Gori., Andrea, Bandera, Alessandra, Muscatello, Antonio, Mangioni, Davide, Alagna, Laura, Bozzi, Giorgio, Lombardi., Andrea, Ungaro, Riccardo, Ancona, Giuseppe, Mussa, Marco, Mariani, Bianca Veronica, Bolis, Matteo, Iannotti, Nathalie, Ludovisi, Serena, Comelli, Agnese, Renisi, Giulia, Biscarini, Simona, Castelli, Valeria, Palomba, Emanuele, Fava, Marco, Peri, Carlo Alberto, Saltini, Paola, Viero, Giulia, Itri, Teresa, Ferroni, Valentina, Pastore, Valeria, Massafra, Roberta, Liparoti, Arianna, Muheberimana, Toussaint, Giommi, Alessandro, Bianco, Rosaria, Chitani, Grazia Eliana, Bobbio, Chiara, De Matteis, Irene, Bonomi, Angelo Bianchi, Peyvandi, Flora, Gualtierotti, Roberta, Ferrari, Barbara, Rossio, Raffaella, Boasi, Nadia, Pagliaro, Erica, Massimo, Costanza, De Caro, Michele, Giachi, Andrea, Montano, Nicola, Vigone, Barbara, Bellocchi, Chiara, Carandina, Angelica, Fiorelli, Elisa, Melli, Valerie, Tobaldini, Eleonora, Blasi, Francesco, Aliberti, Stefano, Spotti, Maura, Terranova, Leonardo, Misuraca, Sofia, D’Adda, Alice, Della Fiore, Silvia, Di Pasquale, Marta, Mantero., Marco, Contarini, Martina, Ori, Margherita, Morlacchi, Letizia, Rossetti, Valeria, Gramegna, Andrea, Pappalettera, Maria, Cavallini, Mirta, Buscemi, Agata, Vicenzi, Marco, Rota, Irena, Costantino, Giorgio, Solbiati, Monica, Furlan, Ludovico, Mancarella, Marta, Colombo, Giulia, Colombo, Giorgio, Fanin, Alice, Passarella, Mariele, Monzani, Valter, Canetta, Ciro, Rovellini, Angelo, Barbetta, Laura, Billi, Filippo, Folli, Christian, Accordino, Silvia, Maira, Diletta, Hu, Cinzia Maria, Motta, Irene, Scaramellini, Natalia, Fracanzani, Anna Ludovica, Lombardi, Rosa, Cespiati, Annalisa, Cesari, Matteo, Lucchi, Tiziano, Proietti, Marco, Calcaterra, Laura, Mandelli, Clara, Coppola, Carlotta, Cerizza, Arturo, Pesenti, Antonio Maria, Grasselli, Giacomo, Galazzi, Alessandro, Nobili., Alessandro, Tettamanti, Mauro, Monti, Igor, Galbussera, Alessia Antonella, Crisafulli, Ernesto, Girelli, Domenico, Maroccia, Alessio, Gabbiani, Daniele, Busti, Fabiana, Vianello, Alice, Biondan, Marta, Sartori, Filippo, Faverio, Paola, Pesci, Alberto, Zucchetti, Stefano, Bonfanti, Paolo, Rossi, Marianna, Beretta, Ilaria, Spolti, Anna, Harari, Sergio, Elia, Davide, Cassandro, Roberto, Caminati, Antonella, Cipollone, Francesco, Guagnano, Maria Teresa, D’Ardes, Damiano, Rossi, Ilaria, Vezzani, Francesca, Spanevello, Antonio, Cherubino, Francesca, Visca, Dina, Contoli, Marco, Papi, Alberto, Morandi, Luca, Battistini, Nicholas, Moreo, Guido Luigi, Iannuzzi, Pasqualina, Fumagalla, Daniele, Leone, Sara, Lombardi, Andrea, Villa, Simone, Colaneri, Marta, Scaglione, Giovanni, Bai, Francesca, Varisco, Benedetta, Bono, Valeria, Vena, Antonio, Dentone, Chiara, Russo, Chiara, Azzarà, Cecilia, Mantero, Marco, Bassetti, Matteo, Marchetti, Giulia, Nobili, Alessandro, and Gori, Andrea
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- 2024
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6. The role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic
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Marta Canuti, Maria Cristina Monti, Chiara Bobbio, Antonio Muscatello, Toussaint Muheberimana, Sante Leandro Baldi, Francesco Blasi, Ciro Canetta, Giorgio Costantino, Alessandro Nobili, Flora Peyvandi, Mauro Tettamanti, Simone Villa, Stefano Aliberti, Mario C. Raviglione, Andrea Gori, Alessandra Bandera, COVID-19 Network Study Group, Bosari Silvano, Scudeller Luigia, Fusetti Giuliana, Rusconi Laura, Dell’Orto Silvia, Prati Daniele, Valenti Luca, Giovannelli Silvia, Manunta Maria, Lamorte Giuseppe, Ferarri Francesca, Mangioni Davide, Alagna Laura, Bozzi Giorgio, Lombardi Andrea, Ungaro Riccardo, Ancona Giuseppe, Zuglian Gianluca, Bolis Matteo, Iannotti Nathalie, Ludovisi Serena, Comelli Agnese, Renisi Giulia, Biscarini Simona, Castelli Valeria, Palomba Emanuele, Fava Marco, Fortina Valeria, Liparoti Arianna, Pastena Andrea, Alberto Peri Carlo, Saltini Paola, Viero Giulia, Itri Teresa, Ferroni Valentina, Pastore Valeria, Massafra Roberta, Curri Maria Teresa, Rizzo Alice, Scarpa Stefano, Giommi Alessandro, Bianco Rosaria, Chitani Grazia Eliana, Gualtierotti Roberta, Ferrari Barbara, Rossio Raffaella, Boasi Nadia, Pagliaro Erica, Massimo Costanza, Caro Michele De, Giachi Andrea, Montano Nicola, Vigone Barbara, Bellocchi Chiara, Carandina Angelica, Fiorelli Elisa, Melli Valerie, Tobaldini Eleonora, Spotti Maura, Terranova Leonardo, Misuraca Sofia, D’Adda Alice, Fiore Silvia Della, Pasquale Marta Di, Mantero Marco, Contarini Martina, Ori Margherita, Morlacchi Letizia, Rossetti Valeria, Gramegna Andrea, Pappalettera Maria, Cavallini Mirta, Buscemi Agata, Vicenzi Marco, Rota Irena, Solbiati Monica, Furlan Ludovico, Mancarella Marta, Colombo Giulia, Colombo Giorgio, Fanin Alice, Passarella Mariele, Monzani Valter, Rovellini Angelo, Barbetta Laura, Billi Filippo, Folli Christian, Accordino Silvia, Maira Diletta, Hu Cinzia Maria, Motta Irene, Scaramellini Natalia, Fracanzani Anna Ludovica, Lombardi Rosa, Cespiati Annalisa, Cesari Matteo, Lucchi Tiziano, Proietti Marco, Calcaterra Laura, Mandelli Clara, Coppola Carlotta, Cerizza Arturo, Grasselli Giacomo, Galazzi Alessandro, Monti Igor, and Galbusera Alessia Antonella
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SARS-CoV-2 ,COVID-19 ,disease outcome ,hospitalization ,COVID-19 vaccination ,immune suppression ,Medicine (General) ,R5-920 - Abstract
Specific immune suppression types have been associated with a greater risk of severe COVID-19 disease and death. We analyzed data from patients >17 years that were hospitalized for COVID-19 at the “Fondazione IRCCS Ca′ Granda Ospedale Maggiore Policlinico” in Milan (Lombardy, Northern Italy). The study included 1727 SARS-CoV-2-positive patients (1,131 males, median age of 65 years) hospitalized between February 2020 and November 2022. Of these, 321 (18.6%, CI: 16.8–20.4%) had at least one condition defining immune suppression. Immune suppressed subjects were more likely to have other co-morbidities (80.4% vs. 69.8%, p
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- 2023
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7. Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy
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Lombardi, Andrea, primary, Villa, Simone, additional, Colaneri, Marta, additional, Scaglione, Giovanni, additional, Bai, Francesca, additional, Varisco, Benedetta, additional, Bono, Valeria, additional, Vena, Antonio, additional, Dentone, Chiara, additional, Russo, Chiara, additional, Tettamanti, Mauro, additional, Renisi, Giulia, additional, Viero, Giulia, additional, Azzarà, Cecilia, additional, Mantero, Marco, additional, Peyvandi, Flora, additional, Bassetti, Matteo, additional, Marchetti, Giulia, additional, Muscatello, Antonio, additional, Nobili, Alessandro, additional, Gori, Andrea, additional, Bandera, Alessandra, additional, Bosari, Silvano, additional, Scudeller, Luigia, additional, Fusetti, Giuliana, additional, Rusconi, Laura, additional, Dell’Orto, Silvia, additional, Prati, Daniele, additional, Valenti, Luca, additional, Giovannelli, Silvia, additional, Manunta, Maria, additional, Lamorte, Giuseppe, additional, Ferarri, Francesca, additional, Gori., Andrea, additional, Mangioni, Davide, additional, Alagna, Laura, additional, Bozzi, Giorgio, additional, Lombardi., Andrea, additional, Ungaro, Riccardo, additional, Ancona, Giuseppe, additional, Mussa, Marco, additional, Mariani, Bianca Veronica, additional, Bolis, Matteo, additional, Iannotti, Nathalie, additional, Ludovisi, Serena, additional, Comelli, Agnese, additional, Biscarini, Simona, additional, Castelli, Valeria, additional, Palomba, Emanuele, additional, Fava, Marco, additional, Peri, Carlo Alberto, additional, Saltini, Paola, additional, Itri, Teresa, additional, Ferroni, Valentina, additional, Pastore, Valeria, additional, Massafra, Roberta, additional, Liparoti, Arianna, additional, Muheberimana, Toussaint, additional, Giommi, Alessandro, additional, Bianco, Rosaria, additional, Chitani, Grazia Eliana, additional, Bobbio, Chiara, additional, De Matteis, Irene, additional, Bonomi, Angelo Bianchi, additional, Gualtierotti, Roberta, additional, Ferrari, Barbara, additional, Rossio, Raffaella, additional, Boasi, Nadia, additional, Pagliaro, Erica, additional, Massimo, Costanza, additional, De Caro, Michele, additional, Giachi, Andrea, additional, Montano, Nicola, additional, Vigone, Barbara, additional, Bellocchi, Chiara, additional, Carandina, Angelica, additional, Fiorelli, Elisa, additional, Melli, Valerie, additional, Tobaldini, Eleonora, additional, Blasi, Francesco, additional, Aliberti, Stefano, additional, Spotti, Maura, additional, Terranova, Leonardo, additional, Misuraca, Sofia, additional, D’Adda, Alice, additional, Della Fiore, Silvia, additional, Di Pasquale, Marta, additional, Mantero., Marco, additional, Contarini, Martina, additional, Ori, Margherita, additional, Morlacchi, Letizia, additional, Rossetti, Valeria, additional, Gramegna, Andrea, additional, Pappalettera, Maria, additional, Cavallini, Mirta, additional, Buscemi, Agata, additional, Vicenzi, Marco, additional, Rota, Irena, additional, Costantino, Giorgio, additional, Solbiati, Monica, additional, Furlan, Ludovico, additional, Mancarella, Marta, additional, Colombo, Giulia, additional, Colombo, Giorgio, additional, Fanin, Alice, additional, Passarella, Mariele, additional, Monzani, Valter, additional, Canetta, Ciro, additional, Rovellini, Angelo, additional, Barbetta, Laura, additional, Billi, Filippo, additional, Folli, Christian, additional, Accordino, Silvia, additional, Maira, Diletta, additional, Hu, Cinzia Maria, additional, Motta, Irene, additional, Scaramellini, Natalia, additional, Fracanzani, Anna Ludovica, additional, Lombardi, Rosa, additional, Cespiati, Annalisa, additional, Cesari, Matteo, additional, Lucchi, Tiziano, additional, Proietti, Marco, additional, Calcaterra, Laura, additional, Mandelli, Clara, additional, Coppola, Carlotta, additional, Cerizza, Arturo, additional, Pesenti, Antonio Maria, additional, Grasselli, Giacomo, additional, Galazzi, Alessandro, additional, Nobili., Alessandro, additional, Monti, Igor, additional, Galbussera, Alessia Antonella, additional, Crisafulli, Ernesto, additional, Girelli, Domenico, additional, Maroccia, Alessio, additional, Gabbiani, Daniele, additional, Busti, Fabiana, additional, Vianello, Alice, additional, Biondan, Marta, additional, Sartori, Filippo, additional, Faverio, Paola, additional, Pesci, Alberto, additional, Zucchetti, Stefano, additional, Bonfanti, Paolo, additional, Rossi, Marianna, additional, Beretta, Ilaria, additional, Spolti, Anna, additional, Harari, Sergio, additional, Elia, Davide, additional, Cassandro, Roberto, additional, Caminati, Antonella, additional, Cipollone, Francesco, additional, Guagnano, Maria Teresa, additional, D’Ardes, Damiano, additional, Rossi, Ilaria, additional, Vezzani, Francesca, additional, Spanevello, Antonio, additional, Cherubino, Francesca, additional, Visca, Dina, additional, Contoli, Marco, additional, Papi, Alberto, additional, Morandi, Luca, additional, Battistini, Nicholas, additional, Moreo, Guido Luigi, additional, Iannuzzi, Pasqualina, additional, Fumagalla, Daniele, additional, and Leone, Sara, additional
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- 2024
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8. New Antibiotics Against Multidrug-Resistant Gram-Negative Bacteria in Liver Transplantation: Clinical Perspectives, Toxicity, and PK/PD Properties
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Lombardi, Andrea, primary, Alagna, Laura, additional, Palomba, Emanuele, additional, Viero, Giulia, additional, Tonizzo, Anna, additional, Mangioni, Davide, additional, and Bandera, Alessandra, additional
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- 2024
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9. Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis
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Kyriazopoulou, Evdoxia, Huet, Thomas, Cavalli, Giulio, Gori, Andrea, Kyprianou, Miltiades, Pickkers, Peter, Eugen-Olsen, Jesper, Clerici, Mario, Veas, Francisco, Chatellier, Gilles, Kaplanski, Gilles, Netea, Mihai G., Pontali, Emanuele, Gattorno, Marco, Cauchois, Raphael, Kooistra, Emma, Kox, Matthijs, Bandera, Alessandra, Beaussier, Hélène, Mangioni, Davide, Dagna, Lorenzo, van der Meer, Jos W.M., Giamarellos-Bourboulis, Evangelos J., Hayem, Gilles, Volpi, Stefano, Sormani, Maria Pia, Signori, Alessio, Bozzi, Giorgio, Minoia, Francesca, Aliberti, Stefano, Grasselli, Giacomo, Alagna, Laura, Lombardi, Andrea, Ungaro, Riccardo, Agostoni, Carlo, Blasi, Francesco, Costantino, Giorgio, Fracanzani, Anna Ludovica, Montano, Nicola, Peyvandi, Flora, Sottocorno, Marcello, Muscatello, Antonio, Filocamo, Giovanni, Papadopoulos, Antonios, Mouktaroudi, Maria, Karakike, Eleni, Saridaki, Maria, Gkavogianni, Theologia, Katrini, Konstantina, Vechlidis, Nikolaos, Avgoustou, Christina, Chalvatzis, Stamatios, Marantos, Theodoros, Damoulari, Christina, Damoraki, Georgia, Ktena, Sofia, Tsilika, Maria, Koufargyris, Panagiotis, Karageorgos, Athanasios, Droggiti, Dionysia-Irene, Koliakou, Aikaterini, Poulakou, Garyfallia, Tsiakos, Konstantinos, Myrodia, Dimitra-Melia, Gravvani, Areti, Trontzas, Ioannis P., Syrigos, Konstantinos, Kalomenidis, Ioannis, Kranidioti, Eleftheria, Panagopoulos, Periklis, Petrakis, Vasileios, Metallidis, Simeon, Loli, Georgia, Tsachouridou, Olga, Dalekos, George N., Gatselis, Nikolaos, Stefos, Aggelos, Georgiadou, Sarah, Lygoura, Vassiliki, Milionis, Haralampos, Kosmidou, Maria, Papanikolaou, Ilias C., Akinosoglou, Karolina, Giannitsioti, Efthymia, Chrysos, Georgios, Mavroudis, Panagiotis, Sidiropoulou, Chrysanthi, Adamis, Georgios, Fragkou, Archontoula, Rapti, Aggeliki, Alexiou, Zoi, Symbardi, Styliani, Masgala, Aikaterini, Kostaki, Konstantina, Kostis, Evangelos, Samarkos, Michael, Bakakos, Petros, Tzavara, Vassiliki, Dimakou, Katerina, Tzatzagou, Glykeria, Chini, Maria, Kotsis, Vasileios, Tsoukalas, George, Bliziotis, Ioannis, Doumas, Michael, Argyraki, Aikaterini, Kainis, Ilias, Fantoni, Massimo, Cingolani, Antonella, Angheben, Andrea, Cardellino, Chiara Simona, Castelli, Francesco, Serino, Francesco Saverio, Nicastri, Emanuele, Ippolito, Giuseppe, Bassetti, Matteo, Selmi, Carlo, Netea, Mihai G, van der Meer, Jos W M, and Giamarellos-Bourboulis, Evangelos J
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- 2021
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10. Toward Environmentally Sustainable Digital Preservation
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Pendergrass, Keith L., Sampson, Walker, Walsh, Tim, and Alagna, Laura
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- 2019
11. Higher levels of IgA and IgG at sepsis onset are associated with higher mortality: results from the Albumin Italian Outcome Sepsis (ALBIOS) trial
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Alagna, Laura, Meessen, Jennifer M. T. A., Bellani, Giacomo, Albiero, Daniela, Caironi, Pietro, Principale, Irene, Vivona, Luigi, Grasselli, Giacomo, Motta, Francesca, Agnelli, Nicolò M., Parrini, Vieri, Romagnoli, Stefano, Keim, Roberto, Di Marzo Capozzi, Francesca, Taccone, Fabio S., Taccone, Walter, Bottazzi, Barbara, Bandera, Alessandra, Cortegiani, Andrea, and Latini, Roberto
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- 2021
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12. Perfusion fluid‐related infections in liver transplant recipients: A 5‐year, single‐center, retrospective study
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Lombardi, Andrea, primary, Renisi, Giulia, additional, Dondossola, Daniele, additional, Palomba, Emanuele, additional, Del Prete, Luca, additional, Viero, Giulia, additional, Zefelippo, Arianna, additional, Azzarà, Cecilia, additional, Maccaro, Angelo, additional, Perali, Carolina, additional, Alagna, Laura, additional, Franchi, Eloisa, additional, Muscatello, Antonio, additional, Gori, Andrea, additional, Grasselli, Giacomo, additional, Donato, Maria Francesca, additional, Matinato, Caterina, additional, Caccamo, Lucio, additional, Antonelli, Barbara, additional, and Bandera, Alessandra, additional
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- 2023
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13. Surgical site infections in liver transplantation in the era of multidrug-resistant bacteria
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BRIGATI, Emilietta, primary, BANDERA, Alessandra, additional, CONSONNI, Dario, additional, GRANCINI, Anna, additional, MAGGI, Umberto, additional, PICONI, Stefania, additional, ALAGNA, Laura, additional, PALOMBA, Emanuele, additional, and CACCAMO, Lucio, additional
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- 2023
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14. Fecal microbiota transplantation in the ICU: perspectives on future implementations
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Alagna, Laura, Haak, Bastiaan W., and Gori, Andrea
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Medical research -- Health aspects ,Medicine, Experimental -- Health aspects ,Microbiota (Symbiotic organisms) -- Health aspects ,Medical colleges -- Health aspects ,Hospital patients -- Health aspects ,Evidence-based medicine -- Health aspects ,Health care industry - Abstract
Author(s): Laura Alagna [sup.1], Bastiaan W. Haak [sup.2], Andrea Gori [sup.1] [sup.3] Author Affiliations: (1) 0000 0004 1757 8749, grid.414818.0, Infectious Diseases Unit, Department of Internal Medicine, Fondazione IRCCS Ca' [...]
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- 2019
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15. Infections during extracorporeal membrane oxygenation: epidemiology, risk factors, pathogenesis and prevention
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Biffi, Stefano, Di Bella, Stefano, Scaravilli, Vittorio, Peri, Anna Maria, Grasselli, Giacomo, Alagna, Laura, Pesenti, Antonio, and Gori, Andrea
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- 2017
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16. Gastrointestinal colonization with multidrug-resistant Gram-negative bacteria during extracorporeal membrane oxygenation: effect on the risk of subsequent infections and impact on patient outcome
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Grasselli, Giacomo, Scaravilli, Vittorio, Alagna, Laura, Bombino, Michela, De Falco, Stefano, Bandera, Alessandra, Abbruzzese, Chiara, Patroniti, Nicolò, Gori, Andrea, and Pesenti, Antonio
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- 2019
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17. Acquiring equipment for obsolete media through crowdsourcing
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Alagna, Laura, primary
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- 2019
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18. Gut and airway microbiota dysbiosis and their role in COVID-19 and long-COVID
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Ancona, Giuseppe, primary, Alagna, Laura, additional, Alteri, Claudia, additional, Palomba, Emanuele, additional, Tonizzo, Anna, additional, Pastena, Andrea, additional, Muscatello, Antonio, additional, Gori, Andrea, additional, and Bandera, Alessandra, additional
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- 2023
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19. Validation of the INCREMENT‐SOT‐CPE score in a large cohort of liver transplant recipients with carbapenem‐resistant Enterobacterales infection
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Rinaldi, Matteo, Bonazzetti, Cecilia, Gallo, Mena, Ferraro, Giuseppe, Freire, Maristela, Terrabuio, Débora Raquel Benedita, Tandoi, Francesco, Romagnoli, Renato, De Rosa, Francesco Giuseppe, Mularoni, Alessandra, Ferrarese, Alberto, Burra, Patrizia, Halpern, Marcia, Balbi, Elizabeth, Simkins, Jacques, Abbo, Lilian, Morrás, Ignacio, Cantero, Mireia, Alagna, Laura, Bandera, Alessandra, Clemente, Wanessa Trinidade, Valerio, Maricela, Fernández, Ainhoa, Muñoz, Patricia, Statlender, Liran, Yahav, Dafna, Camargo, Luis Fernando Aranha, Girão, Evelyne Santana, Grossi, Paolo, Viale, Pierluigi, Curti, Stefania, Giannella, Maddalena, Rinaldi M., Bonazzetti C., Gallo M., Ferraro G., Freire M., Terrabuio D.R.B., Tandoi F., Romagnoli R., De Rosa F.G., Mularoni A., Ferrarese A., Burra P., Halpern M., Balbi E., Simkins J., Abbo L., Morrás I., Cantero M., Alagna L., Bandera A., Clemente W.T., Valerio M., Fernández A., Muñoz P., Statlender L., Yahav D., Camargo L.F.A., Girão E.S., Grossi P., Viale P., Curti S., and Giannella M.
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INCREMENT-SOT-CPE score ,Transplantation ,Infectious Diseases ,CRE infection ,liver transplantation ,SOT - Abstract
Background: Management of infections due to carbapenemase-resistant Enterobacterales (CRE) in solid organ transplant (SOT) recipients remains a difficult challenge. The INCREMENT-SOT-CPE score has been specifically developed from SOT recipients to stratify mortality risk, but an external validation is lacking.Methods: Multicenter retrospective cohort study of liver transplant (LT) recipients colonized with CRE infection who developed infection after transplant over 7-year period. Primary endpoint was all-cause 30-day mortality from infection onset. A comparison between INCREMENT-SOT-CPE and other selected scores was performed. A two-level mixed effects logistic regression model with random effects for the center was fitted. Performance characteristics at optimal cut-point were calculated. Multivariable Cox regression analysis of risk factors for all-cause 30-day mortality was carried out.Results: Overall, 250 CRE carriers developed infection after LT and were analyzed. The median age was 55 years (interquartile range [IQR]: 46-62) and 157 were males (62.8%). All-cause 30-day mortality was 35.6%. A sequential organ failure assessment (SOFA) score >= 11 showed a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of 69.7%, 76.4%, 62.0%, 82.0%, and 74.0%, respectively. An INCREMENT-SOT-CPE >= 11 reported a sensitivity, specificity, PPV, NPV, and accuracy of 73.0%, 62.1%, 51.6%, 80.6% and 66.0%, respectively. At multivariable analysis acute renal failure, prolonged mechanical ventilation, INCREMENT-SOT-CPE score >= 11 and SOFA score >= 11 were independently associated with all-cause 30-day mortality, while a tigecycline-based targeted regimen was found to be protective.Conclusions: Both INCREMENT-SOT-CPE >= 11 and SOFA >= 11 were identified as strong predictors of all-cause 30-day mortality in a large cohort of CRE carriers developing infection after LT.
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- 2023
20. Acute Human Immunodeficiency Virus (HIV) Infection Presenting With Bilateral Interstitial Pneumonia: Case Report and Discussion of Potential HIV-Induced Interstitial Pneumonia
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Peri, Anna Maria, Alagna, Laura, Trovati, Serena, Sabbatini, Francesca, Rona, Roberto, Simonetti, Francesco Roberto, Foresti, Sergio, Migliorino, Guglielmo Marco, Gori, Andrea, and Bandera, Alessandra
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- 2017
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21. 310. Data Curation
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Alagna, Laura
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ipres2018 ,digital preservation ,preservation ,conference proceedings ,310. Data Curation - Abstract
The four papers in Session 310 explore the issues and topics pertaining to the theme of Data Curation with exampes of current practice. Session chair: Laura Alagna.
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- 2022
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22. Beyond the Repository Curatorial Toolkit
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Alagna, Laura and Work, Lauren
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digital preservation ,digital collections ,distributed digital preservation ,curation - Abstract
This toolkit is intended to assist cultural heritage organizations in choosing materials to send to distributed digital preservation (DDP) systems, networks in geographically-dispersed locations designed to perform preservation actions.
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- 2022
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23. Prognostic Value of Mid-Region Proadrenomedullin and In Vitro Interferon Gamma Production for In-Hospital Mortality in Patients with COVID-19 Pneumonia and Respiratory Failure: An Observational Prospective Study
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Mangioni, Davide, primary, Oggioni, Massimo, additional, Chatenoud, Liliane, additional, Liparoti, Arianna, additional, Uceda Renteria, Sara, additional, Alagna, Laura, additional, Biscarini, Simona, additional, Bolis, Matteo, additional, Di Modugno, Adriana, additional, Mussa, Marco, additional, Renisi, Giulia, additional, Ungaro, Riccardo, additional, Muscatello, Antonio, additional, Gori, Andrea, additional, Ceriotti, Ferruccio, additional, and Bandera, Alessandra, additional
- Published
- 2022
- Full Text
- View/download PDF
24. Effectiveness of a Multifaced Antibiotic Stewardship Program: A Pre-Post Study in Seven Italian ICUs
- Author
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Mandelli, Giulia, primary, Dore, Francesca, additional, Langer, Martin, additional, Garbero, Elena, additional, Alagna, Laura, additional, Bianchin, Andrea, additional, Ciceri, Rita, additional, Di Paolo, Antonello, additional, Giani, Tommaso, additional, Giugni, Aimone, additional, Gori, Andrea, additional, Lefons, Ugo, additional, Muscatello, Antonio, additional, Olivieri, Carlo, additional, Pan, Angelo, additional, Pedeferri, Matteo, additional, Rossi, Marianna, additional, Rossolini, Gian Maria, additional, Russo, Emanuele, additional, Silengo, Daniela, additional, Viaggi, Bruno, additional, Bertolini, Guido, additional, and Finazzi, Stefano, additional
- Published
- 2022
- Full Text
- View/download PDF
25. The authors reply
- Author
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Grasselli, Giacomo, Scaravilli, Vittorio, Alagna, Laura, Gori, Andrea, and Pesenti, Antonio
- Published
- 2018
- Full Text
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26. Nosocomial Infections During Extracorporeal Membrane Oxygenation: Incidence, Etiology, and Impact on Patients’ Outcome
- Author
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Grasselli, Giacomo, Scaravilli, Vittorio, Di Bella, Stefano, Biffi, Stefano, Bombino, Michela, Patroniti, Nicolò, Bisi, Luca, Peri, Anna Maria, Pesenti, Antonio, Gori, Andrea, and Alagna, Laura
- Published
- 2017
- Full Text
- View/download PDF
27. How Vaccinations Changed the Outcome of COVID-19 Infections in Kidney Transplant Patients: Single-Center Experience
- Author
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Campise, Mariarosaria, primary, Alfieri, Carlo Maria, additional, Benedetti, Matteo, additional, Perna, Alessandro, additional, Miglio, Roberta, additional, Molinari, Paolo, additional, Cervesato, Angela, additional, Giuliani, Silvia, additional, Gandolfo, Maria Teresa, additional, Regalia, Anna, additional, Cresseri, Donata, additional, Alagna, Laura, additional, Gori, Andrea, additional, and Castellano, Giuseppe, additional
- Published
- 2022
- Full Text
- View/download PDF
28. Nocardia Infections in the Immunocompromised Host: A Case Series and Literature Review
- Author
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Palomba, Emanuele, primary, Liparoti, Arianna, additional, Tonizzo, Anna, additional, Castelli, Valeria, additional, Alagna, Laura, additional, Bozzi, Giorgio, additional, Ungaro, Riccardo, additional, Muscatello, Antonio, additional, Gori, Andrea, additional, and Bandera, Alessandra, additional
- Published
- 2022
- Full Text
- View/download PDF
29. A highly virulent variant of HIV-1 circulating in the Netherlands
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Wymant, Chris, Bezemer, Daniela, Blanquart, François, Ferretti, Luca, Gall, Astrid, Hall, Matthew, Golubchik, Tanya, Bakker, Margreet, Ong, Swee Hoe, Zhao, Lele, Bonsall, David, de Cesare, Mariateresa, MacIntyre-Cockett, George, Abeler-Dörner, Lucie, Albert, Jan, Bannert, Norbert, Fellay, Jacques, Grabowski, M Kate, Gunsenheimer-Bartmeyer, Barbara, Günthard, Huldrych F, Kivelä, Pia, Kouyos, Roger D, Laeyendecker, Oliver, Meyer, Laurence, Porter, Kholoud, Ristola, Matti, van Sighem, Ard, Berkhout, Ben, Kellam, Paul, Cornelissen, Marion, Reiss, Peter, Fraser, Christophe, Aubert, V, Battegay, M, Bernasconi, E, Böni, J, Braun, D L, Bucher, H C, Burton-Jeangros, C, Calmy, A, Cavassini, M, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Furrer, H, Fux, C A, Gorgievski, M, Günthard, H, Haerry, D, Hasse, B, Hirsch, H H, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R, Kovari, H, Ledergerber, B, Martinetti, G, de Tejada, B Martinez, Marzolini, C, Metzner, K, Müller, N, Nadal, D, Nicca, D, Pantaleo, G, Rauch, A, Regenass, S, Rudin, C, Schöni-Affolter, F, Schmid, P, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Vernazza, P, Weber, R, Yerly, S, van der Valk, M, Geerlings, S E, Goorhuis, A, Hovius, J W, Lempkes, B, Nellen, F J B, van der Poll, T, Prins, J M, Reiss, P, van Vugt, M, Wiersinga, W J, Wit, F W M N, van Duinen, M, van Eden, J, Hazenberg, A, van Hes, A M H, Pijnappel, F J J, Smalhout, S Y, Weijsenfeld, A M, Jurriaans, S, Back, N K T, Zaaijer, H L, Berkhout, B, Cornelissen, M T E, Schinkel, C J, Wolthers, K C, Peters, E J G, van Agtmael, M A, Autar, R S, Bomers, M, Sigaloff, K C E, Heitmuller, M, Laan, L M, Ang, C W, van Houdt, R, Jonges, M, Kuijpers, T W, Pajkrt, D, Scherpbier, H J, de Boer, C, van der Plas, A, van den Berge, M, Stegeman, A, Baas, S, Hage de Looff, L, Buiting, A, Reuwer, A, Veenemans, J, Wintermans, B, Pronk, M J H, Ammerlaan, H S M, van den Bersselaar, D N J, de Munnik, E S, Deiman, B, Jansz, A R, Scharnhorst, V, Tjhie, J, Wegdam, M C A, van Eeden, A, Nellen, J, Brokking, W, Elsenburg, L J M, Nobel, H, van Kasteren, M E E, Berrevoets, M A H, Brouwer, A E, Adams, A, van Erve, R, de Kruijf-van de Wiel, B A F M, Keelan-Phaf, S, van der Ven, B, Buiting, A G M, Murck, J L, de Vries-Sluijs, T E M S, Bax, H I, van Gorp, E C M, de Jong-Peltenburg, N C, de Mendonç A Melo, M, van Nood, E, Nouwen, J L, Rijnders, B J A, Rokx, C, Schurink, C A M, Slobbe, L, Verbon, A, Bassant, N, van Beek, J E A, Vriesde, M, van Zonneveld, L M, de Groot, J, Boucher, C A B, Koopmans, M P G, van Kampen, J J A, Fraaij, P L A, van Rossum, A M C, Vermont, C L, van der Knaap, L C, Visser, E, Branger, J, Douma, R A, Cents-Bosma, A S, Duijf-van de Ven, C J H M, Schippers, E F, van Nieuwkoop, C, van Ijperen, J M, Geilings, J, van der Hut, G, van Burgel, N D, Leyten, E M S, Gelinck, L B S, Mollema, F, Davids-Veldhuis, S, Tearno, C, Wildenbeest, G S, Heikens, E, Groeneveld, P H P, Bouwhuis, J W, Lammers, A J J, Kraan, S, van Hulzen, A G W, Kruiper, M S M, van der Bliek, G L, Bor, P C J, Debast, S B, Wagenvoort, G H J, Kroon, F P, de Boer, M G J, Jolink, H, Lambregts, M M C, Roukens, A H E, Scheper, H, Dorama, W, van Holten, N, Claas, E C J, Wessels, E, den Hollander, J G, El Moussaoui, R, Pogany, K, Smit, J V, Struik-Kalkman, D, van Niekerk, T, Pontesilli, O, Lowe, S H, Oude Lashof, A M L, Posthouwer, D, van Wolfswinkel, M E, Ackens, R P, Burgers, K, Schippers, J, Weijenberg-Maes, B, van Loo, I H M, Havenith, T R A, van Vonderen, M G A, Kampschreur, L M, Faber, S, Steeman-Bouma, R, Al Moujahid, A, Kootstra, G J, Delsing, C E, van der Burg-van de Plas, M, Scheiberlich, L, Kortmann, W, van Twillert, G, Renckens, R, Ruiter-Pronk, D, van Truijen-Oud, F A, Cohen Stuart, J W T, Jansen, E R, Hoogewerf, M, Rozemeijer, W, van der Reijden, W A, Sinnige, J C, Brinkman, K, van den Berk, G E L, Blok, W L, Lettinga, K D, de Regt, M, Schouten, W E M, Stalenhoef, J E, Veenstra, J, Vrouenraets, S M E, Blaauw, H, Geerders, G F, 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Godinot, Mathieu, Brunel-Dalmas, Florence, Gibert, Sylvie, Trepo, Christian, Peyramond, Dominique, Miailhes, Patrick, Koffi, Joseph, Thoirain, Valérie, Brochier, Corinne, Baudry, Thomas, Pailhes, Sylvie, Lafeuillade, Alain, Philip, Gisèle, Hittinger, Gilles, Assi, Assi, Lambry, Véronique, Rosenthal, Eric, Naqvi, Alissa, Dunais, Brigitte, Cua, Eric, Pradier, Christian, Durant, Jacques, Joulie, Aline, Quinsat, Denis, Tempesta, Serge, Ravaux, Isabelle, Martin, Isabelle Poizot, Faucher, Olivia, Cloarec, Nicolas, Champagne, Hélène, Pichancourt, Gilles, Morlat, Philippe, Pistone, Thierry, Bonnet, Fabrice, Mercie, Patrick, Faure, Isabelle, Hessamfar, Mojgan, Malvy, Denis, Lacoste, Denis, Pertusa, Marie-Carmen, Vandenhende, Marie-Anne, Bernard, Noëlle, Paccalin, François, Martell, Cédric, Roger-Schmelz, Julien, Receveur, Marie-Catherine, Duffau, Pierre, Dondia, Denis, Ribeiro, Emmanuel, Caltado, Sabrina, Neau, Didier, Dupont, Michel, Dutronc, Hervé, Dauchy, Frédéric, Cazanave, Charles, Vareil, 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Lean, C, Morris, S, Winter, A, Faulkner, S, Goorney, B, Howard, L, Fairley, I, Stemp, C, Short, L, Gomez, M, Young, F, Roberts, M, Green, S, Sivakumar, K, Minton, J, Siminoni, A, Calderwood, J, Greenhough, D, DeSouza, C, Muthern, Lisa, Orkin, C, Murphy, S, Truvedi, M, McLean, K, Hawkins, D, Higgs, C, Moyes, A, Antonucci, S, McCormack, S, Lynn, W, Bevan, M, Fox, J, Teague, A, Anderson, J, Mguni, S, Post, F, Campbell, L, Mazhude, C, Russell, H, Carrick, G, Ainsworth, J, Waters, A, Byrne, P, Johnson, M, Kuldanek, K, Mullaney, S, Lawlor, V, Melville, R, Sukthankar, A, Thorpe, S, Murphy, C, Wilkins, E, Ahmad, S, Green, P, Tayal, S, Ong, E, Meaden, J, Riddell, L, Loay, D, Peacock, K, Blackman, H, Harindra, V, Saeed, A M, Allen, S, Natarajan, U, Williams, O, Lacey, H, Care, C, Bowman, C, Herman, S, Devendra, S V, Wither, J, Bridgwood, A, Singh, G, Bushby, S, Kellock, D, Young, S, Rooney, G, Snart, B, Currie, J, Fitzgerald, M, Arumainayyagam, J, Chandramani, S, Rajamanoharan, S, Robinson, T, Taylor, B, Brewer, C, Mayr, Christoph, Schmidt, Wolfgang, Speidel, Andrea, Strohbach, Frank, Arastéh, Keikawus, Cordes, Christiane, Stündel, Manfred, Claus, Jörg, Baumgarten, Axel, Carganico, Andreas, Ingiliz, Patrick, Dupke, Stephan, Freiwald, Matthias, Rausch, Michael, Moll, Arend, Schleehauf, Dorothea, Hintsche, Bettina, Klausen, Gerd, Jessen, Heiko, Jessen, Arne, Köppe, Siegfried, Kreckel, Peter, Schranz, Dietmar, Fischer, Klaus, Schulbin, Hubert, Speer, Miriam, Glaunsinger, Tobias, Wicke, Thomas, Bieniek, Bernhard, Hillenbrand, Heribert, Schlote, Frank, Lauenroth-Mai, Elke, Schuler, Christoph, Schürmann, Dirk, Wesselmann, Hans, Brockmeyer, Norbert, Gehring, Peter, Schmalöer, Dirk, Hower, Martin, Spornraft-Ragaller, Petra, Häussinger, Dieter, Reuter, Stefan, Esser, Stefan, Markus, Rudolf, Kreft, Burkhard, Berzow, Dirk, Christl, Andreas, Meyer, Andreas, Plettenberg, Andreas, Stoehr, Albrecht, Graefe, Katrin, Lorenzen, Thore, Adam, Axel, Schewe, Knut, Weitner, Lutwin, Fenske, Stefan, Hansen, Stefan, Stellbrink, Hans-Jürgen, Wiemer, Dorothea, Hertling, Sandra, Schmidt, Reinhold, Arbter, Peter, Claus, Bernd, Galle, Peter, Jäger, Hans, Jä Gel-Guedes, Eva, Postel, Nils, Fröschl, Monika, Spinner, Christoph, Bogner, Johannes, Salzberger, Bernd, Schölmerich, Jürgen, Audebert, Franz, Marquardt, Ties, Schaffert, Andreas, Schnaitmann, Eiko, Trein, Andreas, Frietsch, Bernhard, Müller, Marcus, Ulmer, Albrecht, Detering-Hübner, Barbara, Kern, Peter, Schubert, Franz, Dehn, Günther, Schreiber, Maria, Güler, Cengiz, Schmidt, Daniel, Meixenberger, Karolin, Medical Microbiology & Infectious Diseases, Internal Medicine, Virology, Pediatrics, Medical Microbiology and Infection Prevention, AII - Infectious diseases, Global Health, Infectious diseases, APH - Aging & Later Life, Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Internal medicine, VU University medical center, Surgery, AMS - Rehabilitation & Development, APH - Quality of Care, Psychiatry, Pediatric surgery, Neurology, Public and occupational health, APH - Mental Health, Pathology, Cardiology, ACS - Heart failure & arrhythmias, Anesthesiology, IOO, Rehabilitation medicine, Obstetrics and gynaecology, General practice, Gastroenterology and hepatology, Pulmonary medicine, ACS - Pulmonary hypertension & thrombosis, Medical oncology laboratory, Hematology, Epidemiology and Data Science, Physiology, Microbes in Health and Disease (MHD), University of Oxford, Stichting HIV Monitoring [Amsterdam], Universiteit van Amsterdam (UvA), European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Amsterdam UMC - Amsterdam University Medical Center, The Wellcome Trust Sanger Institute [Cambridge], Karolinska Institutet [Stockholm], Robert Koch Institute [Berlin] (RKI), Ecole Polytechnique Fédérale de Lausanne (EPFL), Johns Hopkins University (JHU), Universität Zürich [Zürich] = University of Zurich (UZH), Helsinki University Hospital [Helsinki, Finlande], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, University College of London [London] (UCL), Kymab Ltd, Cambridge, England, Institut Pasteur [Paris] (IP), This study was funded by ERC Advanced Grant PBDR-339251 and a Li Ka Shing Foundation grant, both awarded to C.F. The ATHENA Cohort is managed by Stichting HIV Monitoring and supported by a grant from the Dutch Ministry of Health, Welfare and Sport through the Centre for Infectious Disease Control of the National Institute for Public Health and the Environment., We thank K. Fransen and G. Vanham for help with the Belgian data, O. Ratmann for help in identifying the Dutch clusters, K. Kusejko for testing for additional VB individuals in the SHCS, B. Foley for help with genome sharing, B. Dearlove and L. Thomson for help with software, and J. Herbeck and three other reviewers for helpful suggestions., Contributors and affiliations are listed in the supplementary materials., Department of Medicine, University of Helsinki, Infektiosairauksien yksikkö, HUS Inflammation Center, and Clinicum
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Adult ,Male ,HIV-1/genetics ,Genotype ,Anti-HIV Agents ,Evolution ,[SDV]Life Sciences [q-bio] ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,HIV Infections/drug therapy ,selection ,HIV Infections ,Genome, Viral ,heritability ,epidemic ,human-immunodeficiency-virus ,Evolution, Molecular ,SDG 3 - Good Health and Well-being ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Humans ,Viral ,Phylogeny ,Netherlands ,Multidisciplinary ,Genome ,model ,Virulence ,transmission ,Molecular ,setpoint viral load ,reverse-transcriptase ,dynamics ,Viral Load ,CD4 Lymphocyte Count ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,3121 General medicine, internal medicine and other clinical medicine ,Anti-HIV Agents/therapeutic use ,Mutation ,HIV-1 ,Female ,progression - Abstract
Comment in Does HIV-1 virulence matter in the ART era? Lewitus E, Rolland M. Med (N Y). 2022 Apr 8;3(4):217-219. doi: 10.1016/j.medj.2022.03.003. PMID: 35590149; International audience; We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log 10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV—CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences—is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.
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- 2022
30. The Interplay between Gut Microbiota and the Immune System in Liver Transplant Recipients and Its Role in Infections
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Ancona, Giuseppe, primary, Alagna, Laura, additional, Lombardi, Andrea, additional, Palomba, Emanuele, additional, Castelli, Valeria, additional, Renisi, Giulia, additional, Dondossola, Daniele, additional, Iavarone, Massimo, additional, Muscatello, Antonio, additional, Gori, Andrea, additional, and Bandera, Alessandra, additional
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- 2021
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31. Response
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Grasselli, Giacomo, primary, Scaravilli, Vittorio, additional, Mangioni, Davide, additional, Scudeller, Luigia, additional, Alagna, Laura, additional, Gori, Andrea, additional, and Bandera, Alessandra, additional
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- 2021
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32. Treatment of SARS-CoV-2 relapse with remdesivir and neutralizing antibodies cocktail in a patient with X-linked agammaglobulinaemia
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Palomba, Emanuele, primary, Carrabba, Maria, additional, Zuglian, Gianluca, additional, Alagna, Laura, additional, Saltini, Paola, additional, Fortina, Valeria, additional, Hu, Cinzia, additional, Bandera, Alessandra, additional, Fabio, Giovanna, additional, Gori, Andrea, additional, and Muscatello, Antonio, additional
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- 2021
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33. Mucormycosis in CAPA, a Possible Fungal Super-Infection
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Saltini, Paola, primary, Palomba, Emanuele, additional, Castelli, Valeria, additional, Fava, Marco, additional, Alagna, Laura, additional, Biscarini, Simona, additional, Mantero, Marco, additional, Blasi, Francesco, additional, Grancini, Anna, additional, Bandera, Alessandra, additional, Gori, Andrea, additional, Muscatello, Antonio, additional, and Lombardi, Andrea, additional
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- 2021
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34. Immune Checkpoint Inhibitors in People Living with HIV/AIDS: Facts and Controversies
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Castelli, Valeria, primary, Lombardi, Andrea, additional, Palomba, Emanuele, additional, Bozzi, Giorgio, additional, Ungaro, Riccardo, additional, Alagna, Laura, additional, Mangioni, Davide, additional, Muscatello, Antonio, additional, Bandera, Alessandra, additional, and Gori, Andrea, additional
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- 2021
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35. Fosfomycin therapeutic drug monitoring in real-life: development and validation of a LC-MS/MS method on plasma samples
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Baldelli, Sara, primary, Cerea, Matteo, additional, Mangioni, Davide, additional, Alagna, Laura, additional, Muscatello, Antonio, additional, Bandera, Alessandra, additional, and Cattaneo, Dario, additional
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- 2021
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36. Hospital-Acquired Infections in Critically Ill Patients With COVID-19
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Grasselli, Giacomo, primary, Scaravilli, Vittorio, additional, Mangioni, Davide, additional, Scudeller, Luigia, additional, Alagna, Laura, additional, Bartoletti, Michele, additional, Bellani, Giacomo, additional, Biagioni, Emanuela, additional, Bonfanti, Paolo, additional, Bottino, Nicola, additional, Coloretti, Irene, additional, Cutuli, Salvatore Lucio, additional, De Pascale, Gennaro, additional, Ferlicca, Daniela, additional, Fior, Gabriele, additional, Forastieri, Andrea, additional, Franzetti, Marco, additional, Greco, Massimiliano, additional, Guzzardella, Amedeo, additional, Linguadoca, Sara, additional, Meschiari, Marianna, additional, Messina, Antonio, additional, Monti, Gianpaola, additional, Morelli, Paola, additional, Muscatello, Antonio, additional, Redaelli, Simone, additional, Stefanini, Flavia, additional, Tonetti, Tommaso, additional, Antonelli, Massimo, additional, Cecconi, Maurizio, additional, Foti, Giuseppe, additional, Fumagalli, Roberto, additional, Girardis, Massimo, additional, Ranieri, Marco, additional, Viale, Pierluigi, additional, Raviglione, Mario, additional, Pesenti, Antonio, additional, Gori, Andrea, additional, and Bandera, Alessandra, additional
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- 2021
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37. Fosfomycin therapeutic drug monitoring in real-life: development and validation of a LC-MS/MS method on plasma samples
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Baldelli, Sara, Cerea, Matteo, Mangioni, Davide, Alagna, Laura, Muscatello, Antonio, Bandera, Alessandra, and Cattaneo, Dario
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Individualization of fosfomycin dosing based on therapeutic drug monitoring (TDM) of plasma concentrations could reduce drug-related adverse events and improve clinical outcome in complex clinical conditions. Quantification of fosfomycin in plasma samples was performed by a rapid ultraperformance liquid chromatography mass spectrometry method. Sample preparation involved protein precipitation with [13C3]-fosfomycin benzylamine salt as internal standard. The calibration curve ranged from 2 to 800 mg/L. Within- and between-day precision and accuracy, sensitivity, selectivity, dilution integrity, recovery were investigated and the results met the acceptance criteria. In patients, multiple drug dosing (every 6 or 8 hours) or in continuous administration were adopted, resulting in a large interpatient variability in drug concentrations (from 7.4 mg/L and 644.6 mg/L; CV: 91.1%). In critical care patient setting TDM can represent an important tool to identify the best fosfomycin dosing in single patients, taking into consideration clinical characteristics, infection sites and susceptibility of the treated pathogens.
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- 2021
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38. Additional file 1 of Higher levels of IgA and IgG at sepsis onset are associated with higher mortality: results from the Albumin Italian Outcome Sepsis (ALBIOS) trial
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Alagna, Laura, Meessen, Jennifer M. T. A., Bellani, Giacomo, Albiero, Daniela, Caironi, Pietro, Principale, Irene, Vivona, Luigi, Grasselli, Giacomo, Motta, Francesca, Agnelli, Nicol�� M., Parrini, Vieri, Romagnoli, Stefano, Keim, Roberto, Di Marzo Capozzi, Francesca, Taccone, Fabio S., Taccone, Walter, Bottazzi, Barbara, Bandera, Alessandra, Cortegiani, Andrea, and Latini, Roberto
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Additional file 1: Table S1. Patient characteristics by IgA groups. Table S2. Patient characteristics by IgG groups.Table S3. Patient characteristics by IgM groups.Table S4. Plasma concentrations of IgA, IgG & IgM on day 1, 2 & 7 by day 1 levels.Table S5. Patient characteristics by 90-day survival.
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- 2021
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39. Concurrent Thoracic Endovascular Aortic Repair and Liver Transplant: Multidisciplinary Management of Multiple Posttraumatic Lesions
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Domanin, Maurizio, primary, Antonelli, Barbara, additional, Crotti, Stefania, additional, D'Alessio, Ilenia, additional, Fornoni, Gianluca, additional, Bottino, Nicola, additional, Settembrini, Alberto Maria, additional, Marongiu, Ines, additional, Suriano, Grazia, additional, Tagliabue, Paola, additional, Carrara, Alberto, additional, Alagna, Laura, additional, Trimarchi, Santi, additional, Pesenti, Antonio, additional, and Rossi, Giorgio, additional
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- 2021
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40. Anakinra combined with methylprednisolone in patients with severe COVID-19 pneumonia and hyperinflammation: An observational cohort study
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Bozzi, Giorgio, primary, Mangioni, Davide, additional, Minoia, Francesca, additional, Aliberti, Stefano, additional, Grasselli, Giacomo, additional, Barbetta, Laura, additional, Castelli, Valeria, additional, Palomba, Emanuele, additional, Alagna, Laura, additional, Lombardi, Andrea, additional, Ungaro, Riccardo, additional, Agostoni, Carlo, additional, Baldini, Marina, additional, Blasi, Francesco, additional, Cesari, Matteo, additional, Costantino, Giorgio, additional, Fracanzani, Anna Ludovica, additional, Montano, Nicola, additional, Monzani, Valter, additional, Pesenti, Antonio, additional, Peyvandi, Flora, additional, Sottocorno, Marcello, additional, Muscatello, Antonio, additional, Filocamo, Giovanni, additional, Gori, Andrea, additional, and Bandera, Alessandra, additional
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- 2021
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41. Challenges in the Diagnosis and Management of Bacterial Lung Infections in Solid Organ Recipients: A Narrative Review
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Carugati, Manuela, Morlacchi, Letizia Corinna, Peri, Anna Maria, Alagna, Laura, Rossetti, Valeria, Bandera, Alessandra, Gori, Andrea, and Blasi, Francesco
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Bacteria ,Databases, Factual ,Review ,Bacterial Infections ,Organ Transplantation ,Transplant Recipients ,Anti-Bacterial Agents ,respiratory infections ,Antimicrobial Stewardship ,Drug Resistance, Bacterial ,pneumonia ,Humans ,solid organ transplants ,Respiratory Tract Infections - Abstract
Respiratory infections pose a significant threat to the success of solid organ transplantation, and the diagnosis and management of these infections are challenging. The current narrative review addressed some of these challenges, based on evidence from the literature published in the last 20 years. Specifically, we focused our attention on (i) the obstacles to an etiologic diagnosis of respiratory infections among solid organ transplant recipients, (ii) the management of bacterial respiratory infections in an era characterized by increased antimicrobial resistance, and (iii) the development of antimicrobial stewardship programs dedicated to solid organ transplant recipients.
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- 2020
42. Fosfomycin therapeutic drug monitoring in real-life: development and validation of a LC-MS/MS method on plasma samples.
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Baldelli, Sara, Cerea, Matteo, Mangioni, Davide, Alagna, Laura, Muscatello, Antonio, Bandera, Alessandra, and Cattaneo, Dario
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- 2022
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43. Coronavirus disease 2019 and transplantation: tackling the challenges of SARS‐CoV‐2 infection in waiting list candidates
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Mangioni, Davide, primary, Dondossola, Daniele, additional, Antonelli, Barbara, additional, Alagna, Laura, additional, Invernizzi, Federica, additional, Polli, Federico, additional, Tosetti, Giulia, additional, Muscatello, Antonio, additional, Gori, Andrea, additional, and Rossi, Giorgio, additional
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- 2020
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44. Multidrug-Resistant Gram-Negative Bacteria Decolonization in Immunocompromised Patients: A Focus on Fecal Microbiota Transplantation
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Alagna, Laura, primary, Palomba, Emanuele, additional, Mangioni, Davide, additional, Bozzi, Giorgio, additional, Lombardi, Andrea, additional, Ungaro, Riccardo, additional, Castelli, Valeria, additional, Prati, Daniele, additional, Vecchi, Maurizio, additional, Muscatello, Antonio, additional, Bandera, Alessandra, additional, and Gori, Andrea, additional
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- 2020
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45. Coronavirus disease 2019 and transplantation: A view from the inside
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Gori, Andrea, primary, Dondossola, Daniele, additional, Antonelli, Barbara, additional, Mangioni, Davide, additional, Alagna, Laura, additional, Reggiani, Paolo, additional, Bandera, Alessandra, additional, and Rossi, Giorgio, additional
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- 2020
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46. Fecal Microbiota Transplant: Keep Calm and Carry On, Learning From Experience
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Mangioni, Davide, primary, Alagna, Laura, additional, Gori, Andrea, additional, and Bandera, Alessandra, additional
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- 2020
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47. MOESM1 of Gastrointestinal colonization with multidrug-resistant Gram-negative bacteria during extracorporeal membrane oxygenation: effect on the risk of subsequent infections and impact on patient outcome
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Grasselli, Giacomo, Scaravilli, Vittorio, Alagna, Laura, Bombino, Michela, Falco, Stefano, Bandera, Alessandra, Abbruzzese, Chiara, Patroniti, Nicolò, Gori, Andrea, and Pesenti, Antonio
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Additional file 1: Methods S1. Setting and standard of care. Table S1. Diagnostic criteria for infections. Results—Figure S1. Patients population flowchart. Table S2. Infections at admission. Table S3. Cox regression of the independent risk factors associated to the first NI. Table S4. Infection onset times.
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- 2019
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48. Development of a Risk Prediction Model for Carbapenem-resistant Enterobacteriaceae Infection After Liver Transplantation: A Multinational Cohort Study.
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Giannella, Maddalena, Freire, Maristela, Rinaldi, Matteo, Abdala, Edson, Rubin, Arianna, Mularoni, Alessandra, Gruttadauria, Salvatore, Grossi, Paolo, Shbaklo, Nour, Tandoi, Francesco, Ferrarese, Alberto, Burra, Patrizia, Fernandes, Ruan, Camargo, Luis Fernando Aranha, Asensio, Angel, Alagna, Laura, Bandera, Alessandra, Simkins, Jacques, Abbo, Lilian, and Halpern, Marcia
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RESEARCH ,PREOPERATIVE care ,HOST-bacteria relationships ,STATISTICS ,TIME ,ENTEROBACTERIACEAE diseases ,MEDICAL cooperation ,RETROSPECTIVE studies ,POSTOPERATIVE care ,RISK assessment ,ARTIFICIAL respiration ,THEORY ,REOPERATION ,DESCRIPTIVE statistics ,LIVER transplantation ,PREDICTION models ,LONGITUDINAL method ,ACUTE kidney failure ,DISEASE risk factors - Abstract
Background Patients colonized with carbapenem-resistant Enterobacteriaceae (CRE) are at higher risk of developing CRE infection after liver transplantation (LT), with associated high morbidity and mortality. Prediction model for CRE infection after LT among carriers could be useful to target preventive strategies. Methods Multinational multicenter cohort study of consecutive adult patients underwent LT and colonized with CRE before or after LT, from January 2010 to December 2017. Risk factors for CRE infection were analyzed by univariate analysis and by Fine-Gray subdistribution hazard model, with death as competing event. A nomogram to predict 30- and 60-day CRE infection risk was created. Results A total of 840 LT recipients found to be colonized with CRE before (n = 203) or after (n = 637) LT were enrolled. CRE infection was diagnosed in 250 (29.7%) patients within 19 (interquartile range [IQR], 9–42) days after LT. Pre- and post-LT colonization, multisite post-LT colonization, prolonged mechanical ventilation, acute renal injury, and surgical reintervention were retained in the prediction model. Median 30- and 60-day predicted risk was 15% (IQR, 11–24) and 21% (IQR, 15–33), respectively. Discrimination and prediction accuracy for CRE infection was acceptable on derivation (area under the curve [AUC], 74.6; Brier index, 16.3) and bootstrapped validation dataset (AUC, 73.9; Brier index, 16.6). Decision-curve analysis suggested net benefit of model-directed intervention over default strategies (treat all, treat none) when CRE infection probability exceeded 10%. The risk prediction model is freely available as mobile application at https://idbologna.shinyapps.io/CREPostOLTPredictionModel/. Conclusions Our clinical prediction tool could enable better targeting interventions for CRE infection after transplant. [ABSTRACT FROM AUTHOR]
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- 2021
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49. Beyond the Repository: Integrating Local Preservation Systems with National Distribution Services
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Quinn, Brendan, Weinraub, Evviva, Alagna, Laura, Schaefer, Sibyl, and Caizzi, Carolyn
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- 2018
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50. Combination Antifungal Therapy for Invasive Mold Infections Among Pediatric Patients with Hematological Malignancies: Data from A Real-Life Case-Series
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Peri, Anna Maria, primary, Verna, Marta, additional, Biffi, Stefano, additional, Alagna, Laura, additional, Longhi, Benedetta, additional, Migliorino, Guglielmo Marco, additional, Foresti, Sergio, additional, Bandera, Alessandra, additional, Rovelli, Attilio, additional, Rizzari, Carmelo, additional, Gori, Andrea, additional, and Colombini, Antonella, additional
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- 2019
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