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A highly virulent variant of HIV-1 circulating in the Netherlands
- Source :
- Science, 375(6580):A30, 540-545. American Association for the Advancement of Science, Science, 375, 540-545, Science, 375, 6580, pp. 540-545, Science, Science, 2022, 375 (6580), pp.540-545. ⟨10.1126/science.abk1688⟩, Science, 375(6580), 540-545. AMER ASSOC ADVANCEMENT SCIENCE, Wymant, C, Bezemer, D, Blanquart, F, Ferretti, L, Gall, A, Hall, M, Golubchik, T, Bakker, M, Ong, S H, Zhao, L, Bonsall, D, de Cesare, M, MacIntyre-Cockett, G, Abeler-Dörner, L, Albert, J, Bannert, N, Fellay, J, Grabowski, M K, Gunsenheimer-Bartmeyer, B, Günthard, H F, Kivelä, P, Kouyos, R D, Laeyendecker, O, Meyer, L, Porter, K, Ristola, M, van Sighem, A, Berkhout, B, Kellam, P, Cornelissen, M, Reiss, P, Fraser, C, Aubert, V, Battegay, M, Bernasconi, E, Böni, J, Braun, D L, Bucher, H C, Burton-Jeangros, C, Calmy, A, Cavassini, M, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Furrer, H, Fux, C A, Gorgievski, M, Günthard, H, Haerry, D, Hasse, B, Hirsch, H H, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R, Kovari, H, Ledergerber, B, Martinetti, G, de Tejada, B M, Marzolini, C, Metzner, K, Müller, N, Nadal, D, Nicca, D, Pantaleo, G, Rauch, A, Regenass, S, Rudin, C, Schöni-Affolter, F, Schmid, P, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Vernazza, P, Weber, R, Yerly, S, van der Valk, M, Geerlings, S E, Goorhuis, A, Hovius, J W, Lempkes, B, Nellen, F J B, van der Poll, T, Prins, J M, Reiss, P, van Vugt, M, Wiersinga, W J, Wit, F W M N, van Duinen, M, van Eden, J, Hazenberg, A, van Hes, A M H, Pijnappel, F J J, Smalhout, S Y, Weijsenfeld, A M, Jurriaans, S, Back, N K T, Zaaijer, H L, Berkhout, B, Cornelissen, M T E, Schinkel, C J, Wolthers, K C, Peters, E J G, van Agtmael, M A, Autar, R S, Bomers, M, Sigaloff, K C E, Heitmuller, M, Laan, L M, Ang, C W, van Houdt, R, Jonges, M, Kuijpers, T W, Pajkrt, D, Scherpbier, H J, de Boer, C, van der Plas, A, van den Berge, M, Stegeman, A, Baas, S, Hage de Looff, L, Buiting, A, Reuwer, A, Veenemans, J, Wintermans, B, Pronk, M J H, Ammerlaan, H S M, van den Bersselaar, D N J, de Munnik, E S, Deiman, B, Jansz, A R, Scharnhorst, V, Tjhie, J, Wegdam, M C A, van Eeden, A, Nellen, J, Brokking, W, Elsenburg, L J M, Nobel, H, van Kasteren, M E E, Berrevoets, M A H, Brouwer, A E, Adams, A, van Erve, R, de Kruijf-van de Wiel, B A F M, Keelan-Phaf, S, van der Ven, B, van der Ven, B, Buiting, A G M, Murck, J L, de Vries-Sluijs, T E M S, Bax, H I, van Gorp, E C M, de Jong-Peltenburg, N C, de Mendonç A Melo, M, van Nood, E, Nouwen, J L, Rijnders, B J A, Rokx, C, Schurink, C A M, Slobbe, L, Verbon, A, Bassant, N, van Beek, J E A, Vriesde, M, van Zonneveld, L M, de Groot, J, Boucher, C A B, Koopmans, M P G, van Kampen, J J A, Fraaij, P L A, van Rossum, A M C, Vermont, C L, van der Knaap, L C, Visser, E, Branger, J, Douma, R A, Cents-Bosma, A S, Duijf-van de Ven, C J H M, Schippers, E F, van Nieuwkoop, C, van Ijperen, J M, Geilings, J, van der Hut, G, van Burgel, N D, Leyten, E M S, Gelinck, L B S, Mollema, F, Davids-Veldhuis, S, Tearno, C, Wildenbeest, G S, Heikens, E, Groeneveld, P H P, Bouwhuis, J W, Lammers, A J J, Kraan, S, van Hulzen, A G W, Kruiper, M S M, van der Bliek, G L, Bor, P C J, Debast, S B, Wagenvoort, G H J, Kroon, F P, de Boer, M G J, Jolink, H, Lambregts, M M C, Roukens, A H E, Scheper, H, Dorama, W, van Holten, N, Claas, E C J, Wessels, E, den Hollander, J G, El Moussaoui, R, Pogany, K, Brouwer, A E, Smit, J V, Struik-Kalkman, D, van Niekerk, T, Pontesilli, O, Lowe, S H, Oude Lashof, A M L, Posthouwer, D, van Wolfswinkel, M E, Ackens, R P, Burgers, K, Schippers, J, Weijenberg-Maes, B, van Loo, I H M, Havenith, T R A, van Vonderen, M G A, Kampschreur, L M, Faber, S, Steeman-Bouma, R, Al Moujahid, A, Kootstra, G J, Delsing, C E, van der Burg-van de Plas, M, Scheiberlich, L, Kortmann, W, van Twillert, G, Renckens, R, Ruiter-Pronk, D, van Truijen-Oud, F A, Cohen Stuart, J W T, Jansen, E R, Hoogewerf, M, Rozemeijer, W, van der Reijden, W A, Sinnige, J C, Brinkman, K, van den Berk, G E L, Blok, W L, Lettinga, K D, de Regt, M, Schouten, W E M, Stalenhoef, J E, Veenstra, J, Vrouenraets, S M E, Blaauw, H, Geerders, G F, Kleene, M J, Kok, M, Knapen, M, van der Meché, I B, Mulder-Seeleman, E, Toonen, A J M, Wijnands, S, Wttewaal, E, Kwa, D, van Crevel, R, van Aerde, K, Dofferhoff, A S M, Henriet, S S V, Ter Hofstede, H J M, Hoogerwerf, J, Keuter, M, Richel, O, Albers, M, Grintjes-Huisman, K J T, de Haan, M, Marneef, M, Strik-Albers, R, Rahamat-Langendoen, J, Stelma, F F, Burger, D, Gisolf, E H, Hassing, R J, Claassen, M, Ter Beest, G, van Bentum, P H M, Langebeek, N, Tiemessen, R, Swanink, C M A, van Lelyveld, S F L, Soetekouw, R, van der Prijt, L M M, van der Swaluw, J, Bermon, N, van der Reijden, W A, Jansen, R, Herpers, B L, Veenendaal, D, Verhagen, D W M, Lauw, F N, van Broekhuizen, M C, van Wijk, M, Bierman, W F W, Bakker, M, Kleinnijenhuis, J, Kloeze, E, Middel, A, Postma, D F, Schölvinck, E H, Stienstra, Y, Verhage, A R, Wouthuyzen-Bakker, M, Boonstra, A, de Groot-de Jonge, H, van der Meulen, P A, de Weerd, D A, Niesters, H G M, van Leer-Buter, C C, Knoester, M, Hoepelman, A I M, Arends, J E, Barth, R E, Bruns, A H W, Ellerbroek, P M, Mudrikova, T, Oosterheert, J J, Schadd, E M, van Welzen, B J, Aarsman, K, Griffioen-van Santen, B M G, de Kroon, I, van Berkel, M, van Rooijen, C S A M, Schuurman, R, Verduyn-Lunel, F, Wensing, A M J, Bont, L J, Geelen, S P M, Loeffen, Y G T, Wolfs, T F W, Nauta, N, Rooijakkers, E O W, Holtsema, H, Voigt, R, van de Wetering, D, Alberto, A, van der Meer, I, Rosingh, A, Halaby, T, Zaheri, S, Boyd, A C, Bezemer, D O, van Sighem, A I, Smit, C, Hillebregt, M, de Jong, A, Woudstra, T, Bergsma, D, Meijering, R, van de Sande, L, Rutkens, T, van der Vliet, S, de Groot, L, van den Akker, M, Bakker, Y, El Berkaoui, A, Bezemer, M, Brétin, N, Djoechro, E, Groters, M, Kruijne, E, Lelivelt, K J, Lodewijk, C, Lucas, E, Munjishvili, L, Paling, F, Peeck, B, Ree, C, Regtop, R, Ruijs, Y, Schoorl, M, Schnörr, P, Scheigrond, A, Tuijn, E, Veenenberg, L, Visser, K M, Witte, E C, Ruijs, Y, Van Frankenhuijsen, M, Allegre, T, Makhloufi, D, Livrozet, J-M, Chiarello, P, Godinot, M, Brunel-Dalmas, F, Gibert, S, Trepo, C, Peyramond, D, Miailhes, P, Koffi, J, Thoirain, V, Brochier, C, Baudry, T, Pailhes, S, Lafeuillade, A, Philip, G, Hittinger, G, Assi, A, Lambry, V, Rosenthal, E, Naqvi, A, Dunais, B, Cua, E, Pradier, C, Durant, J, Joulie, A, Quinsat, D, Tempesta, S, Ravaux, I, Martin, I P, Faucher, O, Cloarec, N, Champagne, H, Pichancourt, G, Morlat, P, Pistone, T, Bonnet, F, Mercie, P, Faure, I, Hessamfar, M, Malvy, D, Lacoste, D, Pertusa, M-C, Vandenhende, M-A, Bernard, N, Paccalin, F, Martell, C, Roger-Schmelz, J, Receveur, M-C, Duffau, P, Dondia, D, Ribeiro, E, Caltado, S, Neau, D, Dupont, M, Dutronc, H, Dauchy, F, Cazanave, C, Vareil, M-O, Wirth, G, Le Puil, S, Pellegrin, J-L, Raymond, I, Viallard, J-F, Chaigne de Lalande, S, Garipuy, D, Delobel, P, Obadia, M, Cuzin, L, Alvarez, M, Biezunski, N, Porte, L, Massip, P, Debard, A, Balsarin, F, Lagarrigue, M, Prevoteau du Clary, F, Aquilina, C, Reynes, J, Baillat, V, Merle, C, Lemoing, V, Atoui, N, Makinson, A, Jacquet, J M, Psomas, C, Tramoni, C, Aumaitre, H, Saada, M, Medus, M, Malet, M, Eden, A, Neuville, S, Ferreyra, M, Sotto, A, Barbuat, C, Rouanet, I, Leureillard, D, Mauboussin, J-M, Lechiche, C, Donsesco, R, Cabie, A, Abel, S, Pierre-Francois, S, Batala, A-S, Cerland, C, Rangom, C, Theresine, N, Hoen, B, Lamaury, I, Fabre, I, Schepers, K, Curlier, E, Ouissa, R, Gaud, C, Ricaud, C, Rodet, R, Wartel, G, Sautron, C, Beck-Wirth, G, Michel, C, Beck, C, Halna, J-M, Kowalczyk, J, Benomar, M, Drobacheff-Thiebaut, C, Chirouze, C, Faucher, J-F, Parcelier, F, Foltzer, A, Haffner-Mauvais, C, Hustache Mathieu, M, Proust, A, Piroth, L, Chavanet, P, Duong, M, Buisson, M, Waldner, A, Mahy, S, Gohier, S, Croisier, D, May, T, Delestan, M, Andre, M, Zadeh, M M, Martinot, M, Rosolen, B, Pachart, A, Martha, B, Jeunet, N, Rey, D, Cheneau, C, Partisani, M, Priester, M, Bernard-Henry, C, Batard, M-L, Fischer, P, Berger, J-L, Kmiec, I, Robineau, O, Huleux, T, Ajana, F, Alcaraz, I, Allienne, C, Baclet, V, Meybeck, A, Valette, M, Viget, N, Aissi, E, Biekre, R, Cornavin, P, Merrien, D, Seghezzi, J-C, Machado, M, Diab, G, Raffi, F, Bonnet, B, Allavena, C, Grossi, O, Reliquet, V, Billaud, E, Brunet, C, Bouchez, S, Morineau-Le Houssine, P, Sauser, F, Boutoille, D, Besnier, M, Hue, H, Hall, N, Brosseau, D, Souala, F, Michelet, C, Tattevin, P, Arvieux, C, Revest, M, Leroy, H, Chapplain, J-M, Dupont, M, Fily, F, Patra-Delo, S, Lefeuvre, C, Bernard, L, Bastides, F, Nau, P, Verdon, R, de la Blanchardiere, A, Martin, A, Feret, P, Geffray, L, Daniel, C, Rohan, J, Fialaire, P, Chennebault, J M, Rabier, V, Abgueguen, P, Rehaiem, S, Luycx, O, Niault, M, Moreau, P, Poinsignon, Y, Goussef, M, Mouton-Rioux, V, Houlbert, D, Alvarez-Huve, S, Barbe, F, Haret, S, Perre, P, Leantez-Nainville, S, Esnault, J-L, Guimard, T, Suaud, I, Girard, J-J, Simonet, V, Debab, Y, Schmit, J-L, Jacomet, C, Weinberck, P, Genet, C, Pinet, P, Ducroix, S, Durox, H, Denes, É, Abraham, B, Gourdon, F, Antoniotti, O, Molina, J-M, Ferret, S, Lascoux-Combe, C, Lafaurie, M, Colin de Verdiere, N, Ponscarme, D, De Castro, N, Aslan, A, Rozenbaum, W, Pintado, C, Clavel, F, Taulera, O, Gatey, C, Munier, A-L, Gazaigne, S, Penot, P, Conort, G, Lerolle, N, Leplatois, A, Balausine, S, Delgado, J, Timsit, J, Tabet, M, Gerard, L, Girard, P-M, Picard, O, Tredup, J, Bollens, D, Valin, N, Campa, P, Bottero, J, Lefebvre, B, Tourneur, M, Fonquernie, L, Wemmert, C, Lagneau, J-L, Yazdanpanah, Y, Phung, B, Pinto, A, Vallois, D, Cabras, O, Louni, F, Pialoux, G, Lyavanc, T, Berrebi, V, Chas, J, Lenagat, S, Rami, A, Diemer, M, Parrinello, M, Depond, A, Salmon, D, Guillevin, L, Tahi, T, Belarbi, L, Loulergue, P, Zak Dit Zbar, O, Launay, O, Silbermann, B, Leport, C, Alagna, L, Pietri, M-P, Simon, A, Bonmarchand, M, Amirat, N, Pichon, F, Kirstetter, M, Katlama, C, Valantin, M A, Tubiana, R, Caby, F, Schneider, L, Ktorza, N, Calin, R, Merlet, A, Ben Abdallah, S, Weiss, L, Buisson, M, Batisse, D, Karmochine, M, Pavie, J, Minozzi, C, Jayle, D, Castel, P, Derouineau, J, Kousignan, P, Eliazevitch, M, Pierre, I, Collias, L, Viard, J-P, Gilquin, J, Sobel, A, Slama, L, Ghosn, J, Hadacek, B, Thu-Huyn, N, Nait-Ighil, L, Cros, A, Maignan, A, Duvivier, C, Consigny, P H, Lanternier, F, Shoai-Tehrani, M, Touam, F, Jerbi, S, Bodard, L, Jung, C, Goujard, C, Quertainmont, Y, Duracinsky, M, Segeral, O, Blanc, A, Peretti, D, Cheret, A, Chantalat, C, Dulucq, M J, Levy, Y, Lelievre, J D, Lascaux, A S, Dumont, C, Boue, F, Chambrin, V, Abgrall, S, Kansau, I, Raho-Moussa, M, De Truchis, P, Dinh, A, Davido, B, Marigot, D, Berthe, H, Devidas, A, Chevojon, P, Chabrol, A, Agher, N, Lemercier, Y, Chaix, F, Turpault, I, Bouchaud, O, Honore, P, Rouveix, E, Reimann, E, Belan, A G, Godin Collet, C, Souak, S, Mortier, E, Bloch, M, Simonpoli, A-M, Manceron, V, Cahitte, I, Hiraux, E, Lafon, E, Cordonnier, F, Zeng, A-F, Zucman, D, Majerholc, C, Bornarel, D, Uludag, A, Gellen-Dautremer, J, Lefort, A, Bazin, C, Daneluzzi, V, Gerbe, J, Jeantils, V, Coupard, M, Patey, O, Bantsimba, J, Delllion, S, Paz, P C, Cazenave, B, Richier, L, Garrait, V, Delacroix, I, Elharrar, B, Vittecoq, D, Bolliot, C, Lepretre, A, Genet, P, Masse, V, Perrone, V, Boussard, J-L, Chardon, P, Froguel, E, Simon, P, Tassi, S, Avettand Fenoel, V, Barin, F, Bourgeois, C, Cardon, F, Chaix, M-L, Delfraissy, J F, Essat, A, Fischer, H, Lecuroux, C, Meyer, L, Petrov-Sanchez, V, Rouzioux, C, Saez-Cirion, A, Seng, R, Kuldanek, K, Mullaney, S, Young, C, Zucchetti, A, Bevan, M-A, McKernan, S, Wandolo, E, Richardson, C, Youssef, E, Green, P, Faulkner, S, Faville, R, Herman, S, Care, C, Blackman, H, Bellenger, K, Fairbrother, K, Phillips, A, Babiker, A, Delpech, V, Fidler, S, Clarke, M, Fox, J, Gilson, R, Goldberg, D, Hawkins, D, Johnson, A, Johnson, M, McLean, K, Nastouli, E, Post, F, Kennedy, N, Pritchard, J, Andrady, U, Rajda, N, Donnelly, C, McKernan, S, Drake, S, Gilleran, G, White, D, Ross, J, Harding, J, Faville, R, Sweeney, J, Flegg, P, Toomer, S, Wilding, H, Woodward, R, Dean, G, Richardson, C, Perry, N, Gompels, M, Jennings, L, Bansaal, D, Browing, M, Connolly, L, Stanley, B, Estreich, S, Magdy, A, O'Mahony, C, Fraser, P, Jebakumar, S P R, David, L, Mette, R, Summerfield, H, Evans, M, White, C, Robertson, R, Lean, C, Morris, S, Winter, A, Faulkner, S, Goorney, B, Howard, L, Fairley, I, Stemp, C, Short, L, Gomez, M, Young, F, Roberts, M, Green, S, Sivakumar, K, Minton, J, Siminoni, A, Calderwood, J, Greenhough, D, DeSouza, C, Muthern, L, Orkin, C, Murphy, S, Truvedi, M, McLean, K, Hawkins, D, Higgs, C, Moyes, A, Antonucci, S, McCormack, S, Lynn, W, Bevan, M, Fox, J, Teague, A, Anderson, J, Mguni, S, Post, F, Campbell, L, Mazhude, C, Russell, H, Gilson, R, Carrick, G, Ainsworth, J, Waters, A, Byrne, P, Johnson, M, Fidler, S, Kuldanek, K, Mullaney, S, Lawlor, V, Melville, R, Sukthankar, A, Thorpe, S, Murphy, C, Wilkins, E, Ahmad, S, Green, P, Tayal, S, Ong, E, Meaden, J, Riddell, L, Loay, D, Peacock, K, Blackman, H, Harindra, V, Saeed, A M, Allen, S, Natarajan, U, Williams, O, Lacey, H, Care, C, Bowman, C, Herman, S, Devendra, S V, Wither, J, Bridgwood, A, Singh, G, Bushby, S, Kellock, D, Young, S, Rooney, G, Snart, B, Currie, J, Fitzgerald, M, Arumainayyagam, J, Chandramani, S, Rajamanoharan, S, Robinson, T, Taylor, B, Brewer, C, Mayr, C, Schmidt, W, Speidel, A, Strohbach, F, Arastéh, K, Cordes, C, Stündel, M, Claus, J, Baumgarten, A, Carganico, A, Ingiliz, P, Dupke, S, Freiwald, M, Rausch, M, Moll, A, Schleehauf, D, Hintsche, B, Klausen, G, Jessen, H, Jessen, A, Köppe, S, Kreckel, P, Schranz, D, Fischer, K, Schulbin, H, Speer, M, Glaunsinger, T, Wicke, T, Bieniek, B, Hillenbrand, H, Schlote, F, Lauenroth-Mai, E, Schuler, C, Schürmann, D, Wesselmann, H, Brockmeyer, N, Gehring, P, Schmalöer, D, Hower, M, Spornraft-Ragaller, P, Häussinger, D, Reuter, S, Esser, S, Markus, R, Kreft, B, Berzow, D, Christl, A, Meyer, A, Plettenberg, A, Stoehr, A, Graefe, K, Lorenzen, T, Adam, A, Schewe, K, Weitner, L, Fenske, S, Hansen, S, Stellbrink, H-J, Wiemer, D, Hertling, S, Schmidt, R, Arbter, P, Claus, B, Galle, P, Jäger, H, Jä Gel-Guedes, E, Postel, N, Fröschl, M, Spinner, C, Bogner, J, Salzberger, B, Schölmerich, J, Audebert, F, Marquardt, T, Schaffert, A, Schnaitmann, E, Trein, A, Frietsch, B, Müller, M, Ulmer, A, Detering-Hübner, B, Kern, P, Schubert, F, Dehn, G, Schreiber, M, Güler, C, Gunsenheimer-Bartmeyer, B, Schmidt, D, Meixenberger, K, Bannert, N & Netherlands ATHENA HIV Observational Cohort† 2022, ' A highly virulent variant of HIV-1 circulating in the Netherlands ', Science, vol. 375, no. 6580, A30, pp. 540-545 . https://doi.org/10.1126/science.abk1688
- Publication Year :
- 2022
- Publisher :
- AMER ASSOC ADVANCEMENT SCIENCE, 2022.
-
Abstract
- Comment in Does HIV-1 virulence matter in the ART era? Lewitus E, Rolland M. Med (N Y). 2022 Apr 8;3(4):217-219. doi: 10.1016/j.medj.2022.03.003. PMID: 35590149; International audience; We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log 10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV—CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences—is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.
- Subjects :
- Adult
Male
HIV-1/genetics
Genotype
Anti-HIV Agents
Evolution
[SDV]Life Sciences [q-bio]
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
HIV Infections/drug therapy
selection
HIV Infections
Genome, Viral
heritability
epidemic
human-immunodeficiency-virus
Evolution, Molecular
SDG 3 - Good Health and Well-being
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Humans
Viral
Phylogeny
Netherlands
Multidisciplinary
Genome
model
Virulence
transmission
Molecular
setpoint viral load
reverse-transcriptase
dynamics
Viral Load
CD4 Lymphocyte Count
lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]
3121 General medicine, internal medicine and other clinical medicine
Anti-HIV Agents/therapeutic use
Mutation
HIV-1
Female
progression
Subjects
Details
- Language :
- English
- ISSN :
- 35590149, 00368075, and 10959203
- Database :
- OpenAIRE
- Journal :
- Science, 375(6580):A30, 540-545. American Association for the Advancement of Science, Science, 375, 540-545, Science, 375, 6580, pp. 540-545, Science, Science, 2022, 375 (6580), pp.540-545. ⟨10.1126/science.abk1688⟩, Science, 375(6580), 540-545. AMER ASSOC ADVANCEMENT SCIENCE, Wymant, C, Bezemer, D, Blanquart, F, Ferretti, L, Gall, A, Hall, M, Golubchik, T, Bakker, M, Ong, S H, Zhao, L, Bonsall, D, de Cesare, M, MacIntyre-Cockett, G, Abeler-Dörner, L, Albert, J, Bannert, N, Fellay, J, Grabowski, M K, Gunsenheimer-Bartmeyer, B, Günthard, H F, Kivelä, P, Kouyos, R D, Laeyendecker, O, Meyer, L, Porter, K, Ristola, M, van Sighem, A, Berkhout, B, Kellam, P, Cornelissen, M, Reiss, P, Fraser, C, Aubert, V, Battegay, M, Bernasconi, E, Böni, J, Braun, D L, Bucher, H C, Burton-Jeangros, C, Calmy, A, Cavassini, M, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Furrer, H, Fux, C A, Gorgievski, M, Günthard, H, Haerry, D, Hasse, B, Hirsch, H H, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R, Kovari, H, Ledergerber, B, Martinetti, G, de Tejada, B M, Marzolini, C, Metzner, K, Müller, N, Nadal, D, Nicca, D, Pantaleo, G, Rauch, A, Regenass, S, Rudin, C, Schöni-Affolter, F, Schmid, P, Speck, R, Stöckle, 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