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1. Genotypic characterization of Pseudomonas aeruginosa isolates from Turkish children with cystic fibrosis

Author

Sener Okur D, Yuruyen C, Gungor O, Aktas Z, Erturan Z, Akcakaya N, Camcioglu Y, Cokugras H, and Koksalan K

Subjects
P. aeruginosa, Cystic Fibrosis, PFGE, genotype, phenotype, epidemiology, Infectious and parasitic diseases, RC109-216
Abstract

Dicle Sener Okur,1 Caner Yuruyen,2 Ozge Gungor,2 Zerrin Aktas,2 Zayre Erturan,2 Necla Akcakaya,3 Yildiz Camcioglu,3 Haluk Cokugras,3 Kaya Koksalan41Istanbul University Cerrahpasa, Faculty of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, 34098 Kocamustafapasa, Istanbul, Turkey; 2Istanbul University Istanbul, Faculty of Medicine, Department of Microbiology and Clinical Microbiology, 34390 Capa, Istanbul, Turkey; 3Istanbul University Cerrahpasa, Faculty of Medicine, Department of Pediatrics, Division of Pediatric Infectious Diseases, Clinical Immunology and Allergy, 34098 Kocamustafapasa, Istanbul, Turkey; 4Istanbul University, Institute for Medical Experimental Research (DETAE), 34390 Capa, Istanbul, TurkeyObjective: To identify epidemic and other transmissible Pseudomonas aeruginosa strains, genotypic analyses are required. The aim of this study was to assess the distribution of P. aeruginosa strains within the Turkish pediatric cystic fibrosis (CF) clinic population.Methods: Eighteen patients attending the pediatric CF clinic of Cerrahpasa Medical Faculty were investigated in the study. Throat swab and/or sputum samples were taken from each patient at 3-month intervals. The isolates of patients were analyzed by pulsed-field gel electrophoresis (PFGE). The intra- and interpatient genotypic heterogeneity of isolates was examined to determine the clonal isolates of P. aeruginosa within the cohort.Results: A total of 108 clinical isolates of P. aeruginosa were obtained from 18 patients between May 2013 and May 2014. The pulsotypes of the first patient’s isolates could not be obtained by PFGE. From the remaining 17 patients and 101 isolates, 55 distinct pulsotypes were detected. The number of pulsotypes observed in more than one patient (minor clonal strains, cluster strains) was 8 (14.5%), and one of them colonized three patients. However, none of them was detected in more than three patients. These pulsotypes were composed of 20 isolates. In addition, with the PFGE analysis of 81 isolates, we detected 47 (85.6%) pulsotypes, which belonged to only one patient. Over different periods of this study, only 2 (11.8%) patients were colonized with the same pulsotype.Conclusion: Our study indicates that there was considerable genomic diversity among the P. aeruginosa isolates in our clinic. The presence of shared pulsotypes supports cross-transmission between patients.Keywords: P. aeruginosa, cystic fibrosis, PFGE, genotype, phenotype, epidemiology

Published
2019

13. International Practice Patterns for the Management of Acute Postsurgical and Postintravitreal Injection Endophthalmitis: European Vitreo-Retinal Society Endophthalmitis Study Report 1

Author

Soliman, M. K., Gini, G., Kuhn, F., Iros, M., Parolini, B., Ozdek, S., Michalewska, Z., Bopp, S., Adelman, R. A., Sallam, A. B., Kardaszewska, A., M'Bongo Zindamoyen, A. N., Banker, A., Serhiienko, A., Loo, A., Meireles, A., Aydin, B., Luebke, B., Ozmen, C., Odrobina, D., Bertelli, E., Unsal, E., Kenneth, F., Becquet, F., Hamon, F., Pellegrini, G., Tosi, G. M., Donvito, G., Khaqan, H., Badat, I., Fiser, I., Michalewski, J., Francois Le Rouic, J., Nawrocki, J., Zarallo-Gallardo, J., Lee, J. H., Boninska, K., Nowomiejska, K., Dziegielewski, K., Arrevola, L., Lytvynchuk, L., Elshafei, M., Pietras-Trzpiel, M., Detjen, M., Iglicki, M., Badino, M., Angelina, M., Gavura, M., Hasanreisoglu, M., Karadas, M., Atienza, N., Acar, N., Okonkwo, O., Miesbauer, P., Malgorzata, P. -T., Velez-Montoya, R., Robert, R., Frisina, R., Soyeur, R., Rejdak, R., Giannini, R., Mittal, S., Saidkasimova, S., Abdulsalam, S., Cisiecki, S., Rusnak, S., Teoh, S., Teixeira, S., Altan, T., Schrader, W., Kapran, Z., Aktas, Z., and Szijarto, Z.

Subjects
Male, Endophthalmitis, Incidence, Eye Infections, Bacterial, Disease Management, Angiogenesis Inhibitors, Cataract Extraction, Aged, Anti-Bacterial Agents, Antibiotic Prophylaxis, Europe, Eye Infections, Bacterial, Female, Follow-Up Studies, Humans, Intravitreal Injections, Middle Aged, Ophthalmology, Practice Guidelines as Topic, Retrospective Studies, Societies, Medical, Surgical Wound Infection, Vitrectomy, Medical, Societies
Published
2019

17. Spread of carbapenem-resistant international clones of Acinetobacter baumannii in Turkey and Azerbaijan: a collaborative study

Author

Ahmed, S.S., Alp, E., Ulu-Kilic, A., Dinc, G., Aktas, Z., Ada, B., Bagirova, F., Baran, I., Ersoy, Y., Esen, S., Guven, T.G., Hopman, J., Hosoglu, S., Koksal, F., Parlak, E., Yalcin, A.N., Yilmaz, G., Voss, A., Melchers, W.J., Ahmed, S.S., Alp, E., Ulu-Kilic, A., Dinc, G., Aktas, Z., Ada, B., Bagirova, F., Baran, I., Ersoy, Y., Esen, S., Guven, T.G., Hopman, J., Hosoglu, S., Koksal, F., Parlak, E., Yalcin, A.N., Yilmaz, G., Voss, A., and Melchers, W.J.

Abstract

Contains fulltext : 171531.pdf (publisher's version ) (Closed access), Epidemic clones of Acinetobacter baumannii, described as European clones I, II, and III, are associated with hospital epidemics throughout the world. We aimed to determine the molecular characteristics and genetic diversity between European clones I, II, and III from Turkey and Azerbaijan. In this study, a total of 112 bloodstream isolates of carbapenem-resistant Acinetobacter spp. were collected from 11 hospitals across Turkey and Azerbaijan. The identification of Acinetobacter spp. using conventional and sensitivity tests was performed by standard criteria. Multiplex polymerase chain reaction (PCR) was used to detect OXA carbapenemase-encoding genes (bla OXA-23-like, bla OXA-24-like, bla OXA-51-like, and bla OXA-58-like). Pulsed-field gel electrophoresis (PFGE) typing was used to investigate genetic diversity. The bla OXA-51-like gene was present in all 112 isolates, 75 (67 %) carried bla OXA-23-like, 7 (6.2 %) carried bla OXA-58-like genes, and 5 (4.5 %) carried bla OXA-24-like genes. With a 90 % similarity cut-off value, 15 clones and eight unique isolates were identified. The largest clone was cluster D, with six subtypes. Isolates from clusters D and I were widely spread in seven different geographical regions throughout Turkey. However, F cluster was found in the northern and eastern regions of Turkey. EU clone I was grouped within J cluster with three isolates found in Antalya, Istanbul, and Erzurum. EU clone II was grouped in the U cluster with 15 isolates and found in Kayseri and Diyarbakir. The bla OXA-24-like gene in carbapenemases was identified rarely in Turkey and has been reported for the first time from Azerbaijan. Furthermore, this is the first multicenter study in Turkey and Azerbaijan to identify several major clusters belonging to European clones I and II of A. baumannii.

Published
2016

20. Buchbesprechungen

Author

Lorez, H., Urbanek, F. J., Will, H., Weiss, R., Baron, W., Kerner, H., Stetter, H. J., Bukovics, E., Heinhold, J., Feichtinger, G., Aktas, Z., and Reß, H.

Published
1975
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24. Choroidal thickness measurements in children with isolated growth hormone deficiency

Author

Yalcin, N G, Aktas, Z, Yuce, O, Ikiz, G D G, Hasanreisoglu, M, and Bideci, A

Abstract

PurposeThe aim of this study was to determine the choroidal thickness measurement values in cases with isolated growth hormone deficiency (IGHD), to compare them with the healthy control group by using enhanced depth imaging optical coherence tomography (EDI-OCT), and to evaluate the effect of growth hormone (GH) treatment on choroid.Patients and methodsIn this study, 23 cases who were diagnosed with IGHD as a study group and 46 healthy subjects as a control group were included. All patients and controls underwent a complete ophthalmologic examination, including an examination with EDI-OCT. Choroidal thickness (CT) was measured at the fovea and at 1000 μm intervals from the foveal center in both temporal and nasal directions.ResultsThe mean subfoveal choroidal thickness (SFCT) was 329.04±88.49 μm in the cases with IGHD and 365.35±50.48 μm in the control group (P=0.033). The mean CT at temporal 1 and 2 mm were thinner in the IGHD group than that of control group (P=0.033 and P=0.043, respectively). Nasal quadrant measurements were also found to be thinner in the IGHD cases than that of control group, but the difference was not statistically significant. We found a significant positive correlation between pubertal staging and SFCT (rs=0.607, P=0.006). There was no statistically significant difference in CT values of the study group between before and 12 months after GH treatment (P>0.05).ConclusionThis study shows patients with IGHD has a thinner CT when compared with healthy pediatric cases. GH treatment seems to be not associated with the choroidal development.

Published
2018
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25. Dynamic froth stability: particle size, airflow rate and conditioning time effects.

Author

Aktas Z., Banford A.W., Cilliers J.J., Aktas Z., Banford A.W., and Cilliers J.J.

Abstract

Dynamic froth stability tests were carried out on a platinum group metal ore from Amendelbult in the Merensky Reef, South Africa, in a modified Denver flotation cell. The effects of particle size, conditioning time and airflow rates on the dynamic froth stability were determined in relation to maximum froth height. There was a very strong relationship between froth stability and particle size and the stability also depended on conditioning time. Increasing the conditioning time resulted in a decrease in froth stability, solids content of the concentrate and water recovery. The performance values depended directly on the amount of collector adsorbed on the solid particles. When the conditioning period was increased from 2 to 6 minutes, the sulphur content of the concentrate increased from 2.46% to 3.24%. The degree of hydrophobicity plays an important role in dynamic froth stability and performance values., Dynamic froth stability tests were carried out on a platinum group metal ore from Amendelbult in the Merensky Reef, South Africa, in a modified Denver flotation cell. The effects of particle size, conditioning time and airflow rates on the dynamic froth stability were determined in relation to maximum froth height. There was a very strong relationship between froth stability and particle size and the stability also depended on conditioning time. Increasing the conditioning time resulted in a decrease in froth stability, solids content of the concentrate and water recovery. The performance values depended directly on the amount of collector adsorbed on the solid particles. When the conditioning period was increased from 2 to 6 minutes, the sulphur content of the concentrate increased from 2.46% to 3.24%. The degree of hydrophobicity plays an important role in dynamic froth stability and performance values.

Published
2008

27. Antimicrobial Resistance in Gram-Negative Hospital Isolates: Results of the Turkish HITIT-2 Surveillance Study of 2007

Author

Gur, D., primary, Hascelik, G., additional, Aydin, N., additional, Telli, M., additional, Gültekin, M., additional, Ögünç, D., additional, Arikan, O.A., additional, Uysal, S., additional, Yaman, A., additional, Kibar, F., additional, Gülay, Z., additional, Sumerkan, B., additional, Esel, D., additional, Kayacan, C.B., additional, Aktas, Z., additional, Soyletir, G., additional, Altinkanat, G., additional, Durupinar, B., additional, Darka, O., additional, Akgün, Y., additional, Yayla, B., additional, Gedikoglu, S., additional, Sinirtas, M., additional, Berktas, M., additional, and Yaman, G., additional

Published
2009
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38. Cryorecanalization: keys to success.

Author

Yilmaz A, Aktas Z, Alici IO, Caglar A, Sazak H, Ulus F, Yilmaz, Aydin, Aktaş, Zafer, Alici, Ibrahim Onur, Cağlar, Atalay, Sazak, Hilal, and Ulus, Fatma

Abstract

Background: Symptomatic airway obstructions are common with endobronchial exophytic tumors and may result in lethal complications. Recently, a cryorecanalization procedure has emerged that plays a role in the immediate management of airway obstruction. This study was conducted to investigate the value of cryorecanalization for the immediate management of endobronchial obstructive pathology and to determine the factors that affect the success of the procedure.Methods: We analyzed 40 patients with symptoms of airway obstruction who were admitted to our hospital from 2006 to 2010. Patients with exophytic stenosis due to primary bronchial or metastatic neoplasms who underwent cryorecanalization procedures were included. Patients were excluded if they had involvement of a major artery near the site of the intervention. The procedure was not performed on patients with coagulation abnormalities or thrombocyte count and aggregation problems. The data were collected retrospectively.Results: Successful cryorecanalization was achieved in 72.5 % of patients. We found that the success rate was mainly related to the presence of the distal involvement and the older age of obstruction. Restenosis rate was 17.2 %. [corrected] The mean survival time after the cryorecanalization procedure was 11 ± 12.7 months. No complications occurred in 14 patients. No severe bleeding was observed for any patients, and moderate hemorrhaging occurred in ten patients, which was stopped with an argon plasma coagulator. We experienced no intraoperative mortality.Conclusions: Cryorecanalization is a successful and safe intervention for the immediate management of endobronchial stenosis. Appropriate patient selection and high success rates should be achieved after careful radiological assessments and with early management. [ABSTRACT FROM AUTHOR]

Published
2012

46. The effect of reagent addition strategy on the performance of coal flotation.

Author

Banford A.W., Aktas Z., Banford A.W., and Aktas Z.

Abstract

The recovery and grade of concentrates obtained by flotation is partly dependent upon froth structure, which can be modified by the addition of reagents. Experiments using different strategies of reagent addition for the flotation of Bickershaw coal were carried out, and computer images of flotation froths processed quantitatively. Image processing techniques allowed characterisation of froth structures. A kinetic model was developed to describe the adsorption of the reagent on the particles, and experimental recoveries and froth structure were investigated in terms of reagent distribution and froth structure. The kinetics of reagent adsorption introduces a lag in the regulation of froth structure, and the design of a feedback process will need to take this into account., The recovery and grade of concentrates obtained by flotation is partly dependent upon froth structure, which can be modified by the addition of reagents. Experiments using different strategies of reagent addition for the flotation of Bickershaw coal were carried out, and computer images of flotation froths processed quantitatively. Image processing techniques allowed characterisation of froth structures. A kinetic model was developed to describe the adsorption of the reagent on the particles, and experimental recoveries and froth structure were investigated in terms of reagent distribution and froth structure. The kinetics of reagent adsorption introduces a lag in the regulation of froth structure, and the design of a feedback process will need to take this into account.

47. The effects of frother and collector distribution on flotation performance.

Author

Hadler K., Aktas Z., Cilliers J.J., Hadler K., Aktas Z., and Cilliers J.J.

Abstract

The development is reported of a technique in which the concentration of reagents remaining in solution during batch flotation tests can be measured. By this method, the distribution of reagents in laboratory-scale flotation tests can be studied.Experiments using an industrial sulphide ore found that 20% of the frother Dowfroth 200 was lost in the presence of SIBX collector and that after 2 min, 63% of the SIBX had adsorbed to particles. It was also shown that increases in initial collector concentration and conditioning time yielded a higher concentrate grade., The development is reported of a technique in which the concentration of reagents remaining in solution during batch flotation tests can be measured. By this method, the distribution of reagents in laboratory-scale flotation tests can be studied.Experiments using an industrial sulphide ore found that 20% of the frother Dowfroth 200 was lost in the presence of SIBX collector and that after 2 min, 63% of the SIBX had adsorbed to particles. It was also shown that increases in initial collector concentration and conditioning time yielded a higher concentrate grade.

49. Resection of endobronchial hamartoma causing recurrent hemoptysis by electrocautery and cryotherapy.

Author

Ucar, N., Akpinar, S., Aktas, Z., Sipit, T., and Ozaydin, E.

Subjects
*HEMOPTYSIS, *BRONCHOSCOPY
Abstract

Background:Pulmonary hamartomas are rare benign tumors of the lung with an incidence of 0.025%-0.32%. Endobronchial benign lesions can cause bronchial obstruction and recurrent respiratory infections or obstructive pneumonia and recurrent hemopthysis. Case report: A 66-year-old male with recurrent hemoptysis and pneumonias for a year, was referred to our department for an endoscopic resection of an endobronchial hamartoma. Initially he refused any intervention but, as he suffered additional episodes of hemoptysis and chest infections during a year on follow up, he finally underwent interventional bronchoscopy and the lesion was cauterized using snare electrocautery probe and removed with cryoextraction. The patient has been followed for two years in our outpatient clinic, with no further problems. Conclusion: Endoscopic treatment with flexible bronchoscope, electrocautery and cryotherapy provides an excellent outcome. Surgical therapy, should be reserved for the hamartomas that cannot be approached through endoscopy. [ABSTRACT FROM AUTHOR]

Published
2014

50. Results from the Survey of Antibiotic Resistance (SOAR) 2011-13 in Turkey

Author

Deniz Gür, Gulsen Altinkanat, A. Karadag, Ian Morrissey, Şöhret Aydemir, Cigdem Bal Kayacan, Murat Günaydin, Güner Söyletir, Zerrin Aktaş, D Torumkuney, Alper Tünger, H. Gorur, Belgin Altun, Soyletir, G., Altinkanat, G., Gur, D., Altun, B., Tunger, A., Aydemir, S., Kayacan, C., Aktas, Z., Gunaydin, M., Karadag, A., Gorur, H., Morrissey, I., Torumkuney, D., Ege Üniversitesi, and OMÜ

Subjects
Male, 0301 basic medicine, Turkey, STREPTOCOCCUS-PNEUMONIAE, HAEMOPHILUS-INFLUENZAE, Cefpodoxime, Levofloxacin, polycyclic compounds, Pharmacology (medical), Child, Respiratory Tract Infections, Aged, 80 and over, Sulfamethoxazole, MACROLIDE RESISTANCE, Bacterial Infections, Articles, Middle Aged, Anti-Bacterial Agents, Ciprofloxacin, PYOGENES, Infectious Diseases, Child, Preschool, Female, Macrolides, medicine.drug, Adult, Microbiology (medical), EUROPE, Adolescent, 030106 microbiology, Microbial Sensitivity Tests, Biology, beta-Lactams, Microbiology, Young Adult, 03 medical and health sciences, Clavulanic acid, Drug Resistance, Bacterial, parasitic diseases, medicine, Humans, Aged, Pharmacology, ANTIMICROBIAL RESISTANCE, Bacteria, Infant, Newborn, Infant, COMMUNITY-ACQUIRED PNEUMONIA, ADULTS, biochemical phenomena, metabolism, and nutrition, Amoxicillin, bacterial infections and mycoses, Virology, Trimethoprim, MORAXELLA-CATARRHALIS, Cefixime
Abstract

WOS: 000376292100007, PubMed ID: 27048584, Objectives: Data are presented from the Survey of Antibiotic Resistance (SOAR) for respiratory tract infection pathogens collected in 2011-13 from Turkey. Methods: MICs were determined using Etest (R). Susceptibilitywas assessed using CLSI, EUCASTand pharmacokinetic/pharmacodynamic (PK/PD) interpretive criteria. Results: Rates of antibiotic susceptibility were very low among 333 isolates of Streptococcus pneumoniae tested: penicillin 38% using CLSI (oral) and EUCAST breakpoints; erythromycin 51% using CLSI and EUCAST criteria; and cefuroxime 64.6% using CLSI and PK/PD and 46.9% using EUCAST. Of the isolates, >90% were susceptible to amoxicillin/clavulanic acid, ceftriaxone (except using EUCAST criteria: 76%), levofloxacin and high-dose intravenous penicillin. Among 339 Haemophilus influenzae isolates, 6.8% were beta-lactamase positive while 9.1% were beta-lactamase negative but ampicillin resistant (BLNAR) by CLSI (14.7% by EUCAST) criteria. Amoxicillin/clavulanic acid susceptibility was similar to 90% by CLSI (with or without BLNAR adjustment, EUCAST and high-dose PK/PD) but lower, at 82.9%, by EUCAST with BLNAR adjustment. Levofloxacin susceptibility was 96% using all three breakpoints. Dramatic differences in rates of susceptibility, depending on the breakpoints used, were seen for cefaclor [ 94% by CLSI (86.4% BLNAR adjusted), 23% by PK/PD] and cefuroxime [97% by CLSI (89.1% BLNAR adjusted), 85% by PK/PD, 15% by EUCAST (13.0% BLNAR adjusted)]. Streptococcus pyogenes (n = 222) and Moraxella catarrhalis (n = 40) isolates remained highly susceptible to amoxicillin/clavulanic acid, cephalosporins and levofloxacin, with only erythromycin susceptibility dropping below 95% for S. pyogenes. Conclusions: Overall, amoxicillin/clavulanic acid and levofloxacin were themost active antibiotics based on all three breakpoints against these pathogens. Although susceptibility was not universally low in Turkey, high resistance rates were found in S. pneumoniae and, when using PK/PD and EUCAST breakpoints, in other respiratory pathogens., GlaxoSmithKlineGlaxoSmithKline, This study was funded by GlaxoSmithKline.

Published
2016

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