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Introduction: Arterial and venous thrombotic events in COVID-19 cause significant morbidity and mortality. For optimal thromboprophylaxis treatment for hospitalized patients, especially those with severe COVID-19 symptoms, it is still unclear whether to use full- or therapeutic-dose versus prophylactic-dose anticoagulation therapy. The study aim was to evaluate the efficacy and safety of unfractionated heparin (UFH) for thromboprophylaxis in severe degree of COVID-19. Methodology: In this cross-sectional study, the medical records of 160 COVID-19 patients at the COVID-19 Emergency Hospital Wisma Atlet, Jakarta, from March to August 2021, were collected. The predetermined inclusion criteria for patients were severe COVID-19 infection; age > 18 years; positive D-dimer level > 400 ng/mL; high-flow nasal cannula (HFNC) oxygenation; IMPROVE bleeding risk score < 7; and willingness to participate in the study. The primary outcome was activated partial thromboplastin time (APTT) target achievement, oxygenation changed to nasal cannula or ended with room air, mortality rate, and the principal safety criterion was presence of bleeding. Results: Of 160 subjects, 63.8% were male and 45.6% were aged 45-59 years old. Obesity was the most common comorbidity at 45.6% Among all subjects, 9.4% experienced bleeding, with hematuria being the most frequent type at 66.7%. All subjects released HFNC, and no deaths were reported. Conclusions: It can be concluded that administration of therapeutic doses of heparin in patients with severe COVID-19 had a low risk of bleeding and no patients were reported to have died. However, further investigation is needed to determine the long-term effects of therapeutic doses of anticoagulants. [ABSTRACT FROM AUTHOR]

Objective: Clinical clerkship students, as adolescent health workers, have been first recipients of the COVID-19 vaccination programme. The success rate and trust of recipients in the program have been impacted by adverse events following immunization (AEFI). This study aims to determine the AEFI of the CoronaVac vaccine among clinical clerkship students at the Faculty of Medicine, State Islamic University, Jakarta. Material and Methods: This study used cross sectional methods with a total of 225 subjects completing a questionnaire. The CoronaVac vaccine was administered twice with 2 week interval. AEFI was evaluated after 30 minutes, 24 hours, and on the third day. Results and discussion: 73.3% of the participants were female, 20-25 years old. AEFIs were found in 57.8 % of all participants in the first and second doses vaccination. The most common local AEFI was pain at the site injection, accounting 27.1 % which occurred 30 minutes after second dose vaccination. The most common systemic AEFI was drowsiness, accounting for 18 % which occurred 24 hours after first dose vaccination. Other systemic AEFIs were headache, fatigue, and chills. There was significant association between AEFIs and females but no significant association with history of allergy, comorbidities, and history of previous COVID-19. AEFIs were mild, no special treatment or hospitalization were required. Conclusion: The AEFIs of the CoronaVac vaccine among students were mild and had significant association with females. The study is expected to increase the public's confidence in the COVID-19 vaccination program and to create awareness of its safety. [ABSTRACT FROM AUTHOR]

Introduction: Coagulopathy is commonly seen with coronavirus disease (COVID-19). Abnormal coagulation parameters are important to determine the prognosis and severity of the disease. There is scant evidence of coagulation in the Omicron variant of COVID-19. This study aimed to analyse the correlation between D-dimer level and clinical severity among 284 hospitalised patients with COVID in Jakarta, Indonesia. Methods: A retrospective cross-sectional study was conducted among 284 patients with COVID-19 admitted to Wisma Atlet Kemayoran COVID-19 Emergency Hospital between August 2021 and January 2022. D-dimer levels were determined on I-Chroma cs2100 and x-rays were taken with a Rotanode E7239X. p<0.05 was defined as statistically significant. The analytics were calculated using SPSS ver. 21. Results: Elevated D-dimer was discovered in 175 patients with the Omicron variant of COVID-19 (61.61%). Radiological signs of pneumonia were found in 38 patients (13.3%). Only one patient (0.35% severity rate) was diagnosed with a severe clinical case. A correlation was identified between an elevated D-dimer level and radiological signs of pneumonia in the Omicron variant of COVID-19 (p=0.045). Conclusion: The Omicron variant of COVID-19 tends to generate milder symptoms and less severe cases. Elevated D-dimer can be one of the signs of severity in the Omicron variant of COVID-19 due to its correlation with radiological signs of pneumonia. [ABSTRACT FROM AUTHOR]

Gallstone pancreatitis is the most common cause of acute pancreatitis worldwide with 40-70% of cases. However, only 3-7% of patients with gallstones develop pancreatitis with the major cause dyslipidemia. The management of acute pancreatitis is supportive, but the definitive treatment for gallstone pancreatitis is laparoscopic cholecystectomy (LCC). Several clinical trials have been performed to evaluate optimal timing between early or delayed LCC in mild gallstone pancreatitis. Early LCC is performed within the period of hospital admission or within 2 weeks after discharge. This is a case report of a young woman, 29 years old who had a mild case of gallstone pancreatitis with a history of familial dyslipidemia and chronic alcoholism. This case showed successful of early LCC that performed on 10th day of hospitalization. The treatment shortened hospital stay with no intra or post-operative complication, improving the pancreatic enzyme level and reduced readmission caused by recurrent pancreatitis. [ABSTRACT FROM AUTHOR]

Various types of vaccines are being developed and tested for SARS-CoV-2. The SARS-CoV-2 genome encodes spike glycoproteins, plays essential roles in virus attachment and entry into the host cell. The surface location of the spike glycoprotein has been the main target for the development of vaccines against SARS-CoV-2 which have been proven effective in generating neutralizing. This study aim was to summarise base on vaccination activities that have been carried out after one year of Covid-19 cases taking place in Europe, especially in Germany. Many study suggests that vaccinations prevented Covid-19 infections. Study from Germany found a connection between high vaccination rates and comparatively low excess mortality. A series of vaccines based on the spike glycoprotein has been tested with clinical success and has been shown to be efficient enough to protect individuals. Among the Covid-19 vaccines applied in Germany, the two mRNA vaccines appear more effective and safer than the vector vaccines. All vaccines approved in Germany use the spike glycoprotein as the active immunogenic agent. [ABSTRACT FROM AUTHOR]

Introduction: Depression is the most psychiatric disorder in elderly which has no specific symptom. This condition can affect quality of life in elderly patient. To determine the relationship between possibility of depression with quality of life in elderly in bio-psycho-socio-spiritual perspective. Methods: Cross sectional design, consecutive sampling with 202 respondents. Setting of study were 3 public health centers (puskesmas), puskesmas Ciputat, East Ciputat, and Pondok Ranji in 2018. Respondents filled out modification of Older People’s Quality of Life-35 (OPQOL-35) questionnaire and Spiritual Need Questionnaire (SNQ). Assessment of depression used Geriatric Depression Scale (GDS-15). Results: Fifty four percent of respondents reported good quality of life, while 46% have bad quality of life. Prevalence of normal/not depression 86.1%, mild depression 12.9%, medium depression 0.5%, and severe depression were 0.5%. The result of bivariate analysis found relationship between possibility of depression with quality of life (p=0.04). There was relationship between possibility of depression with quality of life in elderly with bio-psycho-socio-spiritual aspect. Conclusion: The quality-of-life level in the elderly in general is good. The study shows that most respondents do not experience depression but are dominated by those with a poor and moderate quality of life. There is a significant relationship between the likelihood of depression and quality of life in the elderly. [ABSTRACT FROM AUTHOR]

Introduction: Diabetes Mellitus is chronic metabolic disorders characterized by persistent high blood glucose due to impaired insulin secretion or insulin resistance. Garcinia cambogia or Malabar tamarind is a tropical fruit, widely grown in South Asia and Southeast Asia including Indonesia. It is used for food condiment and flavouring and also popular as weight-loss supplement. Garcinia cambogia contains high amount Hydroxy-citric acid (HCA), an active component have shown increased hepatic glycogen synthesis and increased serotonin release in the brain that leading an appetite-suppression effect, which finally decrease body weight. HCA has also been reported could also increase of alpha amylase and intestinal alpha-glucosidase that leading reduction carbohydrate metabolism, however further benefit in diabetes has not been yet elucidated. The aim to this study was to determine the effects of Garcinia cambogia 400 mg/kg body weight (BW) on blood glucose and body weight in streptozotocin-induced diabetic rat after 28 days of decoction. Methods: This experimental study was done in acute diabetic rats using 50 mg/kg BW streptozotocin injection. Garcinia cambogia extract were given daily at 400 mg/kg BW for 28 days. Body weight and blood glucose were analysed according to protocol. Results: This study showed significant reduction of blood glucose (p<0.05), however body weight did not differ significantly after 28 days of decoction. Conclusion: Garcinia cambogia 400 mg/kg BW gave short term effects to reduce blood glucose in diabetic rat after 28 days of decoction. Therefore, Garcinia cambogia may give beneficial effect on diabetic treatment. [ABSTRACT FROM AUTHOR]