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Short-term Effects of Garcinia cambogia on Blood Glucose and Body Weight in Streptozosin-induced Diabetic Rats.

Authors :
Hendarto, Hari
Rifa, Alissa
Dwita, Nounik Cheri
Nurjannah, Intan
Sari, Flori R.
Akbar, Femmy Nurul
Source :
Malaysian Journal of Medicine & Health Sciences. 2022 Supplement, Vol. 18, p78-81. 4p.
Publication Year :
2022

Abstract

Introduction: Diabetes Mellitus is chronic metabolic disorders characterized by persistent high blood glucose due to impaired insulin secretion or insulin resistance. Garcinia cambogia or Malabar tamarind is a tropical fruit, widely grown in South Asia and Southeast Asia including Indonesia. It is used for food condiment and flavouring and also popular as weight-loss supplement. Garcinia cambogia contains high amount Hydroxy-citric acid (HCA), an active component have shown increased hepatic glycogen synthesis and increased serotonin release in the brain that leading an appetite-suppression effect, which finally decrease body weight. HCA has also been reported could also increase of alpha amylase and intestinal alpha-glucosidase that leading reduction carbohydrate metabolism, however further benefit in diabetes has not been yet elucidated. The aim to this study was to determine the effects of Garcinia cambogia 400 mg/kg body weight (BW) on blood glucose and body weight in streptozotocin-induced diabetic rat after 28 days of decoction. Methods: This experimental study was done in acute diabetic rats using 50 mg/kg BW streptozotocin injection. Garcinia cambogia extract were given daily at 400 mg/kg BW for 28 days. Body weight and blood glucose were analysed according to protocol. Results: This study showed significant reduction of blood glucose (p<0.05), however body weight did not differ significantly after 28 days of decoction. Conclusion: Garcinia cambogia 400 mg/kg BW gave short term effects to reduce blood glucose in diabetic rat after 28 days of decoction. Therefore, Garcinia cambogia may give beneficial effect on diabetic treatment. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16758544
Volume :
18
Database :
Academic Search Index
Journal :
Malaysian Journal of Medicine & Health Sciences
Publication Type :
Academic Journal
Accession number :
160638027