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Sweet’s syndrome is an inflammatory disease that occurs mainly in young adults. Its clinical and histological aspects are usually characteristic. Its diagnostic criteria were proposed by von den Driesch. Two major and at least two minor criteria are required to establish the diagnosis. Sweet’s syndrome is classically associated with neutrophilic infiltrate. A few cases of Sweet’s syndrome with dense eosinophil infiltrate have been described. Here, we report a new case of eosinophil-rich Sweet’s syndrome in a young woman without underlying pathology.

Introduction Les dermatoses perforantes (DP) constituent un groupe heterogene de dermatoses rares souvent le temoin d’une pathologie renale ou d’un diabete mal equilibre. Nous decrivons ici 3 cas de DP : deux patients ayant la maladie de kyrle (MK), temoignant d’un diabete mal equilibre, et un patient ayant la collagenose perforante reactionnelle (CPR) liee a une insuffisance renale chronique terminale (IRC). Observation Nos 3 malades, 2 hommes et une femme, avaient un âge moyen de 61 ans (57–65 ans). Les antecedents etaient un diabete (2 cas) et une insuffisance renale chronique (IRC) (1 cas). Le tableau clinique pour ces cas etait une eruption prurigo-like : eruption cutanee prurigineuse touchant les membres inferieurs avec des papulo-nodules ombiliques a centre crouteux ou hyperkeratosique. Les diagnostics de MK et CPR etaient confirmes par l’examen histologique des biopsies cutanees. Les patients etaient traites par des antihistaminiques et des dermocorticoides avec amelioration partielle. Discussion Les DP sont des pathologies rares pouvant etre acquises ou hereditaires. Elles sont caracterisees par l’elimination trans-epidermique de certains constituants du derme. La MK et la CPR en constituent deux entites distinctes histologiquement mais qui se ressemblent cliniquement. Elles s’associent a divers comorbidites qui sont le diabete, l’IRC et plus rarement avec certaines maladies infectieuses ou neoplasies (carcinomes, lymphomes…). Concernant la prise en charge, le traitement symptomatique par des antihistaminiques, dermocorticoides et keratolytiques est souvent peu efficace. Le controle des comorbidites associees peut ameliorer la prise en charge.

Lichen planus pigmentosus is uncommon in childhood and its treatment is often challenging. We report a case of cutaneous lichen planus pigmentosus in a 10-year-old boy, without oral mucosal involvement, two months after an amalgam dental restoration. The diagnosis was based on the histopathological examination of a skin biopsy, the positive patch test to mercury, and the improvement after amalgam removal. Our case report suggests that metal allergy may play a role, and amalgam replacement may be followed by clinical improvement.

Introduction: Les objectifs de notre travail sont d’evaluer l’impact pronostic de la profondeur d’infiltration tumorale du chorion et de l’envahissement ou non de la musculaire muqueuse des tumeurs pT1 de la vessie en etudiant les taux de recidive et de progression, les survies globale, sans recidive et sans progression. Patients et Methodes: La relecture de toutes les lames a ete effectuee pour determiner la presence ou non de la musculaire muqueuse, son envahissement (pT1b) ou non (pT1a) et la profondeur d’envahissement du chorion (pT1 m: envahissement unifocal ≤ 0,5 mm ou pT1e: envahissement unifocal > 0,5 mm ou multiple). Resultats: En fonction de l’invasion de la musculaire muqueuse, les taux de recidive et de progression etaient plus frequents pour les tumeurs pT1b par rapport a celles pT1a, avec un taux de recidive de 84.6% (p = 0,0012) et de progression de 38.5% (p = 0,003). En fonction du degre d’invasion du chorion, la recidive et la progression etaient plus frequentes pour les tumeurs pT1e par rapport a celles pT1 m (respectivement 57.2 (p = 0,05) et 17.9% (p = 0.11)). La survie moyenne sans recidive etait de 70.3 mois pour les tumeurs pT1a et 53.6 mois pour celles pT1b (p = 0,046), et elle etait de 61.7 mois pour les tumeurs pT1e et de 55.5 mois pour celles pT1 m (p = 0,85). Conclusion: Le classement des ces tumeurs en fonction de l’importance d’envahissement du chorion et del’infiltration de la musculaire muqueuse a prouve son efficacite a travers les taux de recidive et de progressiontumorale chez nos malades. Mots cles: tumeur vesicale; survie; recidive; progression de la maladie English Title: Prognostic interest of tumoral infiltration depth of chorion in the evolution of pT1 bladder tumors English Abstract Introduction: The aim of our study was to evaluate the prognostic impact of tumor infiltration depth of the lamina propria and invasion or non-invasion of the muscularis mucosa of pT1 bladder tumors, studyingrecurrence and progression rate, overall survival, disease-free survival and progression-free survival. Patients and methods: All slides were reviewed to determine the presence or absence of muscularis mucosa,invasion above (pT1a) or below (pT1b) the muscularis mucosa, and the invasion depth of the lamina propria (pT1m: a single focus of lamina propria invasion ≤0.5 mm, pT1e: single focus >0.5 mm of lamina propriainvasion or multiple micro-invasive area). Results: Depending on the invasion of the muscularis mucosa, the rate of recurrence and progression wasmore frequent in pT1b tumors in comparison to patients classified pT1a, with a recurrence rate of 84.6% ( p = 0.0012) and a progression rate of 38.5% ( p = 0.003). Depending on the degree of invasion of the laminapropria, the rate of recurrence and progression was more frequent for pT1e tumors in comparison to pT1m,with a recurrence rate of 57.2% ( p = 0.05) and a progression rate of 17.9% ( p = 0.11). Disease-free survivalwas 70.3 months for pT1a tumors against 53.6 months for pT1b tumors ( p = 0.046), and it was 61.7 monthsfor pT1e tumors against 55.5 months for pT1m tumors ( p = 0.85). Conclusion: The classification of bladder tumors based on the invasion of the lamina propria has provedits efficiency through the recurrence rate and the progression rate among our patients. Keywords: urinary bladder neoplasms, survival analysis, recurrence, disease progression

Fetal rhabdomyomatous nephroblastoma (FRN) is a rare variant of Wilms tumor with distinct morphologic features and biologic behavior compared to conventional nephroblastoma. It mainly occurs in patients under 4 years. In adults, extremely rare cases of nephroblastoma were reported. Among these cases, none has been interested a FRN. We report an exceptional case of a 31-year-old woman diagnosed with FRN discovered incidentally, to illustrate clinical and histopathological characteristics of this entity.

L'objectif de ce travail était de déterminer la valeur diagnostique de la cytoponction à l'aiguille fine (CPAF) et son apport dans la prise en charge des tumeurs parotidiennes, à travers une étude rétrospective portant sur 47 patients opérés d'une tumeur parotidienne et ayant eu une cytoponction préopératoire. Quatre-vingt-un pourcent des malades présentaient une tumeur bénigne et 19% une tumeur maligne. La sensibilité et la spécificité de la CPAF étaient respectivement de 78% et de 92%. Les tumeurs parotidiennes ont été correctement classées comme malignes ou bénignes dans 89% des cas, le taux d'exactitude globale était de 64,4%. La CPAF est un examen fiable permettant une information préopératoire sur le planning thérapeutique et les suites postopératoires.

This study aimed to determine the diagnostic value of fine needle aspiration biopsy (FNAB) and of its contribution to the management of parotid tumors. We conducted a retrospective study of 47 patients who had undergone parotidectomy as well as preoperative fine needle aspiration biopsy. The study highlighted that eighty one percent of patients had a benign tumor while 19% of patients had a malignant tumor. The sensitivity and specificity of FNAB were 78% and 92% respectively. Parotid tumors were correctly classified as malignant or benign in 89% of cases, overall accuracy was 64.4%. FNAB is a reliable examination providing preoperative informations about the treatment plan and the postoperative course.

Resume Le placenta accreta est une adherence anormale du placenta directement sur le myometre sans interposition de caduque. La forme percreta (PP) est la plus rare mais expose a des complications hemorragiques graves au cours de la grossesse. Le diagnostic est difficile a poser surtout lors du premier et du deuxieme trimestre de la grossesse. A travers deux cas de PP compliques de rupture uterine, les auteurs discutent les facteurs de risque, les difficultes diagnostiques et therapeutiques de cette pathologie.

Case We describe a 55-year-old woman suffering from Sezary syndrome, had undergone chemotherapy consisting of cycles of cyclophosphamide and prednisone. 10 months later, she noticed a progressively increasing reticulated generalised pigmentation in the face, trunk and the extremities. Cylophosphamide was withdrawn. The hyperpigmentation began to clear slowly and gradually after 7 months. One year after cyclophosphamide withdrawal and facing the relapse of the disease, and its transformation to a large T cell lymphoma a mini CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) protocol was held, leading to a remarkable aggravation of the pigmentation. Conclusion This adverse drug reaction to cyclophosphamide is peculiar by its localization and distribution and should be known in order not to confuse with other dermatosis.

The spontaneous subcapsular hematoma of the liver is very rare. There are only a few reported cases in the literature.Most reported cases of liver hematoma often occur during pregnancy as part of the hemolysis, elevated liver enzymes, and low platelet count syndrome. The other causes may be due to amylosis, rupture of hepatocellular carcinoma, adenoma, focal nodular hyperplasia, hemorrhagic cyst, or hemopathy. Idiopathic spontaneous subscapular hematoma is a rare and often fatal condition.We report a case of a 43-year-old woman having Steinert disease who died because of a fatal spontaneous liver hemorrhage occurring without any traumatism. We did not find any apparent cause that could explain this hemorrhage even after a histological study of the liver.

Frequency of the association between non-Hodgkin's lymphoma (NHL) and the hepatitis C virus (HCV) infection is variable according to previous studies. Besides, direct and/or indirect implication of the HCV infection in the development of NHL is probable but, its pathophysiological mechanisms remain unclear. In this report, we described the case of a 49-year-old patient with a B-cell NHL of the sacrum complicating a chronic HCV related to a blood exposure, and we report the recent data of this association.

Epithelial ovarian tumors are uncommon before 20 years of age and rarely occur before puberty. The vast majority of these tumors are benign, and few cases of malignant and borderline tumors are described. We report a case of a 4-year-old premenarchal girl, previously healthy, who presented with two abdominal masses. Laboratory analysis of blood showed elevation of the serum level of the CA-125. Ultrasonographic examination disclosed bilateral cystic ovarian masses. Laparoscopic exploration revealed bilateral ovarian multicystic masses with retro-uterine peritoneal implant. Bilateral salpingo-oophorectomy with implant resection was performed. Histologic findings were consistent with a serous borderline tumors of both ovaries and the peritoneal implant was of the non-invasive type. There is no evidence of recurrence at 3-year follow-up. To our knowledge, there are only four cases of ovarian borderline tumors in premenarchal girls reported in the English literature: three of the mucinous type and only one of the serous type.

Resume Introduction L’amylose secondaire est une complication grave de la polyarthrite rhumatoide (PR). Elle est longtemps asymptomatique incitant a sa recherche systematique notamment dans les PR anciennes. Les objectifs de notre etude sont la determination de la prevalence de l’amylose a un stade infraclinique au cours de la PR par aspiration de la graisse abdominale (AGA) en comparaison avec la biopsie des glandes salivaires accessoires (BGSA) et la recherche des facteurs associes a cette amylose. Methodes Notre travail prospectif a porte sur 107 cas de PR (94 femmes et 13 hommes), inclus de facon consecutive pendant la periode allant de mars 2005 a janvier 2006. Nous avons precise pour chaque patient les caracteristiques cliniques, biologiques, radiologiques et therapeutiques. Tous nos patients ont eu une AGA et une BGSA ; la recherche de depots amyloides a ete effectuee par un microscope a lumiere polarisee apres coloration au rouge Congo. Resultats La prevalence de l’amylose infraclinique par AGA est de 21,5 %. Elle n’est que de 3,7 % par BGSA. Les facteurs associes a l’amylose infraclinque sont un delai diagnostique long ( p = 0,03), la presence de manifestations extra-articulaires ( p = 0,019), la proteinurie superieure a 0,3 g/24 heures ( p = 0,024) et la non-utilisation de methotrexate ( p = 0,046). Il n’y avait pas de correlation avec le depot amyloide en ce qui concerne l’âge, le sexe, la duree d’evolution de la PR, les deformations articulaires, le DAS28, le HAQ, le stade radiologique de Steinbrocker, le facteur rhumatoide, la vitesse de sedimentation, la CRP, la creatinine et l’hemoglobine. Conclusion La prevalence de l’amylose infraclinique par AGA au cours de PR est elevee (21,5 %). L’AGA est plus sensible que la BGSA pour la detection de cette amylose. Il convient de la rechercher par une technique simple, comme l’AGA notamment en cas de presence de facteurs de risque. Sa decouverte incite a une surveillance etroite et reguliere afin de depister et traiter precocement une amylose symptomatique.

Resume Les tumeurs angiomatoides de la thyroide sont des tumeurs hautement malignes caracterisees sur le plan morphologique par leur differenciation vasculaire et leur polymorphisme cytologique. Leur histogenese reste un sujet de controverse, entre les defenseurs d’une origine angiosarcomateuse et ceux qui suggerent qu’il s’agit d’une variante angiomatoide du carcinome anaplasique. Nous rapportons un cas de tumeur angiomatoide de la thyroide survenu chez une femme de 68 ans et nous discutons a travers une revue de la litterature les criteres anatomopathologiques permettant d’aider dans la distinction entre angiosarcome primitif et carcinome anaplasique.

Gastrointestinal stromal tumors (GIST) are mesenchymal tumors occuring in the majority of cases in the stomach and small intestine, rarely in rectum, colon, esophagus or mesentery. They are derived from cells of cajal or their precursor, and are typically CD117/KIT + (95%), CD34 + (70%).is to study the epidemiological, clinical, therapeutic and evolution of gastrointestinal stromal tumors.retrospective study including all patients with the diagnosis of GIST supported in the department of gastroenterology and surgery in universital hospital of Monastir.25 patients were included, 12 men and 13 women with an average age of 60.5 years. Digestive symptomatology was dominated by gastrointestinal bleeding (n = 12) and abdominal pain (n = 12). The tumor was discovered incidentally in two patients. The small intestine was the most common site of the tumor (n = 10), followed by the stomach in 9 patients, rectum in two patients, the colon (n = 1), the bulb of water (n = 1), duodenum (n = 1) and liver in a patient. The tumor size ranged from 0.8 to 24 cm. GIST was localized in 16 patients, in whom therapeutic care based mainly on surgery and optimal broad. It was metastatic in 9 patients, in whom treatment using imatinib as first-line in 4 of them with a good response in 3 patients and the possibility of R0 surgery in one patient, initial stabilization and then a secondary exhaust in a patient. The first surgery was necessary in 5 patients in complicated situation or if diagnostic doubt.The best characterization of GIST thanks to advances in cancer research has led to improved treatment of these tumors. Surgery is the standard treatment in localized forms. Imatinib is the standard treatment in metastatic GIST first line as well as adjuvant after surgery.

Primary liposarcoma of the lung is extremely rare. We report a 28-year-old pregnant woman who complained of dyspnoea during the third trimester. Chest radiography, thoracic ultrasound, CT and MRI showed a huge heterogeneous tumour involving all the left lung and the mediastinum. The tumour was composed of soft tissue, and fatty and cystic components with calcifications. Diagnosis was made on core biopsy under CT guidance. Surgical excision was performed but unfortunately the patient died during the operation.

A broad spectrum of paraneoplastic dermatoses is associated with lung cancer. We report herein a 56-year-old man who presented an association of erythroderma, acquired ichthyosis, palmo-plantar keratoderma, hypereosinophilia and hyper IgE. In light of these clinical and biological assessments an underlying malignancy had been suspected. A thoracic, abdominal and pelvic computed tomography showed a left hilar mass. The patient underwent a left pneumonectomy and the histological study had confirmed a non-small cell lung cancer. Recognition of cutaneous paraneoplastic syndromes is important since it leads to prompt diagnosis of an underlying malignancy and consequently a better management and prognosis of the disease.Key words: Carcinoma, paraneoplastic dermatoses, IgE

Multiple myeloma (MM) is a rare cancer. Cutaneous involvement is uncommon with fewer than 100 cases described in the literature. We report herein a patient with MM, subtype IgA kappa, with unusual clinical presentation including the lower lip.

Lipoma arborescens is a rare benign intra-articular lesion of unknown etiology that usually involves the suprapatellar pouch of the knee joint. Clinically, the most common finding is a slow-growing painless swelling, accompanied by intermittent effusion of the joint. We report a case of a multifocal lipoma arborescens localized in the knees and the hips in a 24-year-old man, initially mimicking an inflammatory arthropathy. The diagnosis of lipoma arborescens was made by magnetic resonance imaging of the hips and the knees. Under arthroscopic guidance, the synovial biopsy of the right knee disclosed the specific histological signs of lipoma arborescens. As far as we know, this is the third case of multifocal lipoma arborescens reported in the English literature.

Introduction : Laryngeal adenoid cystic carcinoma (ACC) is unusual. It accounts for 0.25% of all malignant tumors in the larynx, and only about 120 cases have been reported in the literature until now. Purpose : We report a case of subglottic ACC and examine the clinical, diagnostic, histological and therapeutic features and the outcome of this tumor in this location. Case report : A 75-year-old man, presented with a laryngeal dyspnea. The computed tomography of the larynx showed a posterior subglottic tumor. The panendoscopy revealed a large nonulcerated submucosal tumor in the posterior wall of the subglottic area. Biopsies made the diagnosis of laryngeal ACC. The patient had total laryngectomy with total thyroidectomy and bilateral lateral neck dissection. Histological examination didn't find neck metastases. The surgery was followed by a postoperative radiotherapy. There were no local recurrence or distant metastases during one year and half of follow-up. Conclusions : ACC shows a very slow growth pattern. Its diagnosis is often delayed and its treatment is based on surgery and postoperative radiotherapy. This tumor is characterized by the occurrence of local recurrence and distant metastases often several years after treatment of the primary tumor. Keywords : adenoid cystic carcinoma, subglottic, surgery, postoperative radiotherapy, survival.

Objectives : Pleormorphic adenoma is a benign tumor of salivary gland. It mainly occurs in the parotid gland. The submandibular and minor salivary glands are rarely sites of occurrence. We describe the features of pleomorphic adenoma occurring at these sites. Material and methods : Between 2000 and 2009, 15 cases of pleomorphic adenoma occurring externly to the parotid have been collected. Results : Tumors were seen in the submandibular gland in 40 % of cases, in the hard palate in 33 % of cases, in the upper lip in 20 % of cases and in the parapharyngeal space in 7 % of cases. The mean age of patients was 48 years. The majority of cases were female. All patients were operated. We didn't report recurrence or malignants tumors after one year follow-up. Conclusion : After the parotid gland, the most common site of a pleomorphic adenoma is the submandibular gland followed by minor salivary gland of palate and lips. Each localisation has his clinical and therapeutic particularities. Key words : pleomorphic adenoma, submandibular gland, minor salivary gland

Merkel cell carcinoma (MCC) or primary neuroendocrine carcinoma of the skin is a rare neoplasm with aggressive behavior. Primary lymphoepithelioma-like (LEL) carcinoma of the skin is a recently described exceptional tumor, with a relatively good prognosis, and is characterized by a neoplastic epithelial component associated with a dense lymphoid stroma. Rarely, MCC shows a marked lymphocytic host response or can even mimic a LEL carcinoma. We report a new case of MCC mimicking an LEL carcinoma in a 72-year-old male; the diagnosis of MCC was made on the basis of the morphology and immunohistochemical findings. We present through this case an exceptional pattern of MCC which can be misleading, and we insist on differential diagnoses.

But de la presentation Evaluer la place de la cytoponction a l’aiguille fine dans la prise en charge des adenopathies cervicales. Materiel et methodes Une etude retrospective qui porte sur l’analyse de 172 cytoponctions realisees chez 150 patients sur une periode de 3 ans (2005–2007) avec confrontation cyto-histologique dans les cas ou une biopsie ou une intervention chirurgicale a ete faite. Resultats L’âge moyen de la population etudiee au moment de la cytoponction etait de 37,5 ans. Les patients se repartissaient en 69 hommes (46 %) et 81 femmes (54 %) avec une sex-ratio de 1,17. Les resultats cytologiques ont ete classes en 4 groupes : benin (57 %) domine par la tuberculose ganglionnaire (45 %), malin (18 %) domine par les metastases de carcinomes epidermoide (30 %), suspect de malignite (4 %) et non contributif (21 %). La confrontation cyto-histologique, effectuee pour 50 patients, a montre un taux de concordance de 90 %, une sensibilite de 85,7 %, une specificite de 95,4 %, une valeur predictive positive de 96 % et une valeur predictive negative de 84 %. Conclusion Ces resultats stipulent que la cytoponction a l’aiguille fine est une technique simple qui occupe une place de choix dans le diagnostic etiologique des adenopathies cervicales.

The primitif antiphospholpid antibody syndrome is a clinico-biologic entity characterized by the artério-venous thromboses and the presence of circulating antibodies against membranous phospholipids. The systemic demonstrations and in particular ulcerated and ischemic colitises are brought back unusually during this affection.Report a new case.We bring back one observations of ischemic colitis complicated of perforation revealing a primitif antiphospholpid antibody syndrome at a male patient aged of 45 and requiring the surgical intervention.This observation recall an exceptional étiology but often unrecognized of ischemic colitises.

The development of a squamous cell carcinoma within a nevus sebaceous of Jadassohn is very rare. We report here for the first time, the simultaneous occurrence of two squamous cell carcinomas within a single nevus sebaceous of Jadassohn.

Les tumeurs germinales a localisation cervico-faciale sont rares. Nous rapportons l\'observation d\'une une fillette de 7 ans porteuse d\'une tumeur maligne a cellules germinales de l\'espace para-pharynge droit traite par chimiotherapie. Les particularites etiopathogeniques, therapeutiques, et pronostiques de cette tumeur sont rappelees apres une revue des donnees de la litterature. Extragonadal germ cell tumors of the head and neck are very rare. We report the case of a 7-year-old girl with malignant germ cell tumor of the right parapharyngeal space treated by chemotherapy. Etiopathogenic, therapeutic, and prognostic characteristics of this tumour are recalled after a review of the literature data. Keywords : Extragonadal germ cell tumors, parapharyngeal tumors. Journal Tunisien d\'ORL et de chirurgie cervico-faciale Vol. 18 2007: pp. 61-63

Summary Introduction Secondary amyloidosis is a serious complication of rheumatoid arthritis (RA). Symptoms are late to occur, so that screening is in order, most notably in patients with long-standing RA. The objectives of our study were to determine the prevalence of subclinical amyloidosis in RA patients by abdominal fat aspiration biopsy (AFAB) and minor salivary gland biopsy (MSGB) and to identify factors associated with subclinical amyloidosis. Methods We prospectively studied 107 consecutive patients with RA (94 women and 13 men) recruited between March 2005 and January 2006. Clinical and laboratory findings, imaging study results, and treatment were recorded for each patient. AFAB and MSGB were performed routinely. Amyloid deposits were identified by polarized light microscopy after Congo red staining. Results The prevalence of subclinical amyloidosis was 21.5% by AFAB and 3.7% by MSGB. Factors associated with subclinical amyloidosis were a longer time to diagnosis ( P = 0.03), extraarticular manifestations ( P = 0.019), proteinuria >0.3 g/24 h ( P = 0.024), and absence of methotrexate therapy ( P = 0.046). Subclinical amyloidosis was not associated with age, sex, RA duration, joint deformities, DAS28 score, Health Assessment Questionnaire score, Steinbrocker radiological stage, rheumatoid factor, erythrocyte sedimentation rate, C-reactive protein, creatinine, or hemoglobin. Conclusion The prevalence of subclinical amyloidosis by AFAB is high (21.5%). AFAB is more sensitive than MSGB for detecting subclinical amyloidosis. A simple screening tool such as AFAB should be used, particularly in patients with risk factors. Subclinical amyloidosis requires close monitoring to ensure the early detection and treatment of symptomatic amyloidosis.

Plexiform fibrohistiocytic tumour is a rare soft-tissue tumour of intermediate malignancy. It is more prevalent in children and in young adults. We report a case of this tumour presenting as a nontender swelling on the shoulder of an 8-year-old girl. Clinically, the mass was subcutaneous and measured 2 cm in greatest diameter. The histopathological examination revealed a mesenchymal dermic and subcutaneous tumour composed of confluent nodules. These nodules were made of aggregates of histiocyte-like cells and concentric fascicles of spindle cells. The stroma was myxoïd or collagenous. This case was particular by the lack of giant cells and the focally myxoid background. The epidemiologic, clinicopathologic features and outcome of this lesion are discussed and similar published cases are reviewed.

Thyroid gland angiomatoid tumors are an extremely aggressive neoplasms with varied histological patterns and features of endothelial differentiation. The histogenesis of thyroid angiomatoid tumors has been controversial for many years: these tumors may be either a variant of anaplastic carcinoma, or an angiosarcoma. We report a case of thyroid angiomatoid tumor in a 68-year-old woman. We also discuss, through a review of the literature, the pathologic criteria that could be used to distinguish between angiosarcoma and anaplastic carcinoma of the thyroid.

Skin involvement is a late complication that rarely occurs in ovarian cancer patients. This event invariably carries a bad prognosis in the course of an advanced stage ovarian carcinoma which is usually of the conventional serous type. Micropapillary serous carcinoma (MPSC) was recently recognized as a distinct neoplasm that seems to be less aggressive than conventional serous ovarian carcinoma. Indeed, a few cases of stage IV MPSC have been reported. Herein, we describe an unusual case of ovarian invasive MPSC occurring in a young woman, particularly by its mode of presentation as multiple subcutaneous nodules that were subsequently diagnosed as metastatic lesions. This case demonstrates the potential of MPSC for aggressive clinical behaviour.

Micropapillary bladder carcinoma is a recently described, rare variant of urothelial carcinoma reputed for its poor prognosis. The authors report the case of a 59-year-old man with invasive bladder tumour presenting with haematuria. Histological examination of resection chips revealed the typical histological features of high nuclear grade micropapillary carcinoma with invasion of the musculosa and the presence of numerous endolymphatic emboli. The authors discuss the clinicopathological and pathogenic features, treatment and clinical course of this tumour.

Inverted urothelial papilloma is a rare tumour particularly in the ureter. It is difficult to distinguish microscopically from low-grade urothelial carcinoma, inverted type. The authors report a new case of ureteric inverted papilloma in a 64-year-old man and discuss the histological diagnostic criteria, clinical features and prognosis of this tumour.

Encrusted cystitis is a chronic inflammation of the bladder mucosa associated with calcified deposits induced by numerous bacteria in an alkaline medium. Corynebacterium urealyticum or group D2 is most frequently incriminated. Encrusted cystitis is a rare disease with non-specific clinical features. The diagnosis may be suspected on imaging, but is often only established later on histological findings. Treatment of this disease is based on appropriate antibiotics with acidification of the urine. The authors report a new case of encrusted cystitis in a 78-year-old woman and review the literature on encrusted lesions of the urinary tract.