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1. Deep learning assisted measurement of echocardiographic left heart parameters: improvement in interobserver variability and workflow efficiency

Author

Mor-Avi, Victor, Blitz, Alexandra, Schreckenberg, Marcus, Addetia, Karima, Kebed, Kalie, Scalia, Gregory, Badano, Luigi P., Kirkpatrick, James N., Gutierrez-Fajardo, Pedro, Tude Rodrigues, Ana Clara, Sadeghpour, Anita, Tucay, Edwin S., Prado, Aldo D., Tsang, Wendy, Ogunyankin, Kofo O., Rossmanith, Alexander, Schummers, Georg, Laczik, Dorottya, Asch, Federico M., and Lang, Roberto M.

Published
2023
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3. Neutralization, effector function and immune imprinting of Omicron variants

Author

Addetia, Amin, Piccoli, Luca, Case, James Brett, Park, Young-Jun, Beltramello, Martina, Guarino, Barbara, Dang, Ha, de Melo, Guilherme Dias, Pinto, Dora, Sprouse, Kaitlin, Scheaffer, Suzanne M., Bassi, Jessica, Silacci-Fregni, Chiara, Muoio, Francesco, Dini, Marco, Vincenzetti, Lucia, Acosta, Rima, Johnson, Daisy, Subramanian, Sambhavi, Saliba, Christian, Giurdanella, Martina, Lombardo, Gloria, Leoni, Giada, Culap, Katja, McAlister, Carley, Rajesh, Anushka, Dellota, Jr, Exequiel, Zhou, Jiayi, Farhat, Nisar, Bohan, Dana, Noack, Julia, Chen, Alex, Lempp, Florian A., Quispe, Joel, Kergoat, Lauriane, Larrous, Florence, Cameroni, Elisabetta, Whitener, Bradley, Giannini, Olivier, Cippà, Pietro, Ceschi, Alessandro, Ferrari, Paolo, Franzetti-Pellanda, Alessandra, Biggiogero, Maira, Garzoni, Christian, Zappi, Stephanie, Bernasconi, Luca, Kim, Min Jeong, Rosen, Laura E., Schnell, Gretja, Czudnochowski, Nadine, Benigni, Fabio, Franko, Nicholas, Logue, Jennifer K., Yoshiyama, Courtney, Stewart, Cameron, Chu, Helen, Bourhy, Hervé, Schmid, Michael A., Purcell, Lisa A., Snell, Gyorgy, Lanzavecchia, Antonio, Diamond, Michael S., Corti, Davide, and Veesler, David

Published
2023
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7. Echocardiographic Detection of Regional Wall Motion Abnormalities Using Artificial Intelligence Compared to Human Readers

Author

Slivnick, Jeremy A., Gessert, Nils T., Cotella, Juan I., Oliveira, Lucas, Pezzotti, Nicola, Eslami, Parastou, Sadeghi, Ali, Wehle, Simon, Prabhu, David, Waechter-Stehle, Irina, Chaudhari, Ashish M., Szasz, Teodora, Lee, Linda, Altenburg, Marie, Saldana, Giancarlo, Randazzo, Michael, DeCara, Jeanne M., Addetia, Karima, Mor-Avi, Victor, and Lang, Roberto M.

Published
2024
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8. Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice

Author

Hunt, Andrew C, Case, James Brett, Park, Young-Jun, Cao, Longxing, Wu, Kejia, Walls, Alexandra C, Liu, Zhuoming, Bowen, John E, Yeh, Hsien-Wei, Saini, Shally, Helms, Louisa, Zhao, Yan Ting, Hsiang, Tien-Ying, Starr, Tyler N, Goreshnik, Inna, Kozodoy, Lisa, Carter, Lauren, Ravichandran, Rashmi, Green, Lydia B, Matochko, Wadim L, Thomson, Christy A, Vögeli, Bastian, Krüger, Antje, VanBlargan, Laura A, Chen, Rita E, Ying, Baoling, Bailey, Adam L, Kafai, Natasha M, Boyken, Scott E, Ljubetič, Ajasja, Edman, Natasha, Ueda, George, Chow, Cameron M, Johnson, Max, Addetia, Amin, Navarro, Mary Jane, Panpradist, Nuttada, Gale, Michael, Freedman, Benjamin S, Bloom, Jesse D, Ruohola-Baker, Hannele, Whelan, Sean PJ, Stewart, Lance, Diamond, Michael S, Veesler, David, Jewett, Michael C, and Baker, David

Subjects
Medical Biotechnology, Engineering, Biomedical and Clinical Sciences, Biomedical Engineering, Vaccine Related, Lung, Emerging Infectious Diseases, Biodefense, Pneumonia, Autoimmune Disease, Infectious Diseases, Pneumonia & Influenza, Prevention, Biotechnology, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Good Health and Well Being, Animals, Antibodies, Neutralizing, Antibodies, Viral, COVID-19, Cryoelectron Microscopy, Humans, Mice, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Biological Sciences, Medical and Health Sciences, Medical biotechnology, Biomedical engineering
Abstract

New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to arise and prolong the coronavirus disease 2019 (COVID-19) pandemic. Here, we used a cell-free expression workflow to rapidly screen and optimize constructs containing multiple computationally designed miniprotein inhibitors of SARS-CoV-2. We found the broadest efficacy was achieved with a homotrimeric version of the 75-residue angiotensin-converting enzyme 2 (ACE2) mimic AHB2 (TRI2-2) designed to geometrically match the trimeric spike architecture. Consistent with the design model, in the cryo-electron microscopy structure TRI2-2 forms a tripod at the apex of the spike protein that engaged all three receptor binding domains simultaneously. TRI2-2 neutralized Omicron (B.1.1.529), Delta (B.1.617.2), and all other variants tested with greater potency than the monoclonal antibodies used clinically for the treatment of COVID-19. TRI2-2 also conferred prophylactic and therapeutic protection against SARS-CoV-2 challenge when administered intranasally in mice. Designed miniprotein receptor mimics geometrically arrayed to match pathogen receptor binding sites could be a widely applicable antiviral therapeutic strategy with advantages over antibodies in greater resistance to viral escape and antigenic drift, and advantages over native receptor traps in lower chances of autoimmune responses.

Published
2022

9. Anomalous right coronary artery from the main pulmonary artery (ARCAPA): Incidental finding in an asymptomatic septuagenarian

Author

Nicole Prabhu, MD, Brittney Guile, RDCS, Maxine Tang, MD, Linda Lee, MD, Luis Landeras, MD, Roberto M. Lang, MD, Nitasha Sarswat, MD, and Karima Addetia, MD

Subjects
Coronary anomaly, Congenital heart disease, Cardiac CT, ARCAPA, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Anomalous right coronary artery (RCA) from the main pulmonary artery (ARCAPA) is a rare finding. Clinical presentations range from asymptomatic to sudden death. We present the case of ARCAPA in a septuagenarian initially suspected on a screening chest computed tomography (CT) and later confirmed on cardiac CT. A summary of important points related to this entity is also discussed.

Published
2023
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10. Cardiovascular computed tomography for the detection of quadricuspid aortic valve: A case report

Author

Edward Yang, MD, Husam H. Balkhy, MD, Brooke Patel, ANP, Juan Cotella, MD, Luis Landeras, MD, Karima Addetia, MD, and Jeremy A. Slivnick, MD

Subjects
Aortic regurgitation, Cardiac CT, Valvular heart disease, Aortic valve, Cardiac surgery, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Aortic regurgitation (AR) represents a significant cause of morbidity and mortality. Due to its low cost and widespread availability, echocardiography remains the frontline for aortic valve (AV) assessment. However, poor sonographic windows may limit the assessment of valve morphology with this technique. Cardiovascular computed tomography (CCT) is increasingly utilized prior to structural AV interventions. Due to its excellent spatial resolution, CCT provides exceptional characterization of aortic leaflets. Accordingly, we present a case of a quadricuspid valve diagnosed by CCT. Here, CCT led to a new diagnosis of quadricuspid valve, highlighting the potential for CCT for the characterization of aortic leaflet morphology. CCT may be particularly useful in patients with contraindications to transesophageal echocardiography or those undergoing structural or robotic interventions.

Published
2023
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11. Managing Implanted Cardiac Electronic Devices in Patients With Severe Tricuspid Regurgitation: JACC State-of-the-Art Review

Author

Hahn, Rebecca T., Wilkoff, Bruce Larry, Kodali, Susheel, Birgersdotter-Green, Ulrika Maria, Ailawadi, Gorav, Addetia, Karima, Andreas, Martin, Auricchio, Angelo, Ehlert, Frederick, George, Isaac, Gupta, Aakriti, Harrison, Rachel, Ho, Edwin C., Kusumoto, Fred, Latib, Azeem, O’Gara, Patrick, Patton, Kristen K., Pinney, Sean, Zeitler, Emily P., Mack, Michael J., Leon, Martin B., and Epstein, Laurence M.

Published
2024
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14. SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

Author

Starr, Tyler N, Czudnochowski, Nadine, Liu, Zhuoming, Zatta, Fabrizia, Park, Young-Jun, Addetia, Amin, Pinto, Dora, Beltramello, Martina, Hernandez, Patrick, Greaney, Allison J, Marzi, Roberta, Glass, William G, Zhang, Ivy, Dingens, Adam S, Bowen, John E, Tortorici, M Alejandra, Walls, Alexandra C, Wojcechowskyj, Jason A, De Marco, Anna, Rosen, Laura E, Zhou, Jiayi, Montiel-Ruiz, Martin, Kaiser, Hannah, Dillen, Josh R, Tucker, Heather, Bassi, Jessica, Silacci-Fregni, Chiara, Housley, Michael P, di Iulio, Julia, Lombardo, Gloria, Agostini, Maria, Sprugasci, Nicole, Culap, Katja, Jaconi, Stefano, Meury, Marcel, Dellota Jr, Exequiel, Abdelnabi, Rana, Foo, Shi-Yan Caroline, Cameroni, Elisabetta, Stumpf, Spencer, Croll, Tristan I, Nix, Jay C, Havenar-Daughton, Colin, Piccoli, Luca, Benigni, Fabio, Neyts, Johan, Telenti, Amalio, Lempp, Florian A, Pizzuto, Matteo S, Chodera, John D, Hebner, Christy M, Virgin, Herbert W, Whelan, Sean PJ, Veesler, David, Corti, Davide, Bloom, Jesse D, and Snell, Gyorgy

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Vaccine Related, Lung, Prevention, Biodefense, Pneumonia & Influenza, Emerging Infectious Diseases, Immunization, Pneumonia, Biotechnology, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Good Health and Well Being, Adult, Aged, Animals, Antibodies, Monoclonal, Antibodies, Viral, Antibody Affinity, Broadly Neutralizing Antibodies, COVID-19, COVID-19 Vaccines, Cell Line, Cricetinae, Cross Reactions, Epitopes, B-Lymphocyte, Female, Humans, Immune Evasion, Male, Mesocricetus, Middle Aged, Models, Molecular, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Vaccinology, COVID-19 Drug Treatment, General Science & Technology
Abstract

An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape1-3, have activity against diverse sarbecoviruses4-7, and be highly protective through viral neutralization8-11 and effector functions12,13. Understanding how these properties relate to each other and vary across epitopes would aid the development of therapeutic antibodies and guide vaccine design. Here we comprehensively characterize escape, breadth and potency across a panel of SARS-CoV-2 antibodies targeting the receptor-binding domain (RBD). Despite a trade-off between in vitro neutralization potency and breadth of sarbecovirus binding, we identify neutralizing antibodies with exceptional sarbecovirus breadth and a corresponding resistance to SARS-CoV-2 escape. One of these antibodies, S2H97, binds with high affinity across all sarbecovirus clades to a cryptic epitope and prophylactically protects hamsters from viral challenge. Antibodies that target the angiotensin-converting enzyme 2 (ACE2) receptor-binding motif (RBM) typically have poor breadth and are readily escaped by mutations despite high neutralization potency. Nevertheless, we also characterize a potent RBM antibody (S2E128) with breadth across sarbecoviruses related to SARS-CoV-2 and a high barrier to viral escape. These data highlight principles underlying variation in escape, breadth and potency among antibodies that target the RBD, and identify epitopes and features to prioritize for therapeutic development against the current and potential future pandemics.

Published
2021

16. Three-Dimensional Transthoracic Echocardiography for Semiautomated Analysis of the Tricuspid Annulus: Validation and Normal Values

Author

Prado, Aldo D., Filipini, Eduardo, Ronderos, Ricardo E., Samantha Hoschke-Edwards, Agatha Kwon, Scalia, Gregory M., Afonso, Tania Regina, Tude Rodridugues, Ana Clara, Thampinathan, Babitha, Sooriyakanthan, Maala, Tsang, Wendy, Wang, Yingbin, Zhang, Yu, Zhu, Tiangang, Wang, Zhilong, Alagesan, R., Balasubramanian, S., Ananth, R.V.A., Amuthan, Vivekanandan, Bansal, Manish, Kasliwal, Ravi R., Alizadehasl, Azin, Sadeghpour, Anita, Bossone, Eduardo, Nakao, Tomoko, Kawata, Takayuki, Hirokawa, Megumi, Sawada, Naoko, Daimon, Masao, Nabeshima, Yousuke, Takeuchi, Masaki, Fajardo, Pedro Gutierrez, Ogunyankin, Kofo O., Tucay, Edwin S., Yun, Hye Rim, Park, Seung Woo, Hwang, Ji-won, Monaghan, Mark J., Kirkpatrick, James N., Miyoshi, Tatsuya, Cotella, Juan I., Blitz, Alexandra, Clement, Alexandra, Tomaselli, Michele, Muraru, Denisa, Badano, Luigi P., Sauber, Natascha, Font Calvarons, Adria, Degel, Markus, Rucki, Agnieszka, Blankenhagen, Michael, Yamat, Megan, Schreckenberg, Marcus, Addetia, Karima, Asch, Federico M., Mor-Avi, Victor, and Lang, Roberto M.

Published
2024
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17. Added value of 3D echocardiography in the diagnosis and prognostication of patients with right ventricular dysfunction

Author

Michael Randazzo, Francesco Maffessanti, Alekhya Kotta, Julia Grapsa, Roberto M. Lang, and Karima Addetia

Subjects
3D echocardiography, right ventricle, prognosis, echocardiography, tricuspid valve, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Recent inroads into percutaneous-based options for the treatment of tricuspid valve disease has brought to light how little we know about the behavior of the right ventricle in both health and disease and how incomplete our assessment of right ventricular (RV) physiology and function is using current non-invasive technology, in particular echocardiography. The purpose of this review is to provide an overview of what three-dimensional echocardiography (3DE) can offer currently to enhance RV evaluation and what the future may hold if we continue to improve the 3D evaluation of the right heart.

Published
2023
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18. Preservation of Circumferential and Radial Left Ventricular Function as a Mitigating Mechanism for Impaired Longitudinal Strain in Early Cardiac Amyloidosis

Author

Slivnick, Jeremy A., Singulane, Cristiane, Sun, Deyu, Eshun, Derek, Narang, Akhil, Mazzone, Steven, Addetia, Karima, Patel, Amit R., Zareba, Karolina M., Smart, Suzanne, Kwon, Jung Woo, Husain, Aliya, Cody, Brittany, Scheetz, Seth, Asch, Federico M., Goyal, Akash, Sarswat, Nitasha, Mor-Avi, Victor, and Lang, Roberto M.

Published
2023
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19. Variations in indexation of left atrial volume across different races

Author

Prado, Aldo D., Addetia, Karima, Bellino, Michele, Daimon, Masao, Fajardo, Pedro Gutierrez, Kasliwal, Ravi R., Kirkpatrick, James N., Monaghan, Mark J., Muraru, Denisa, Ogunyankin, Kofo O., Park, Seung Woo, Ronderos, Ricardo E., Sadeghpour, Anita, Scalia, Gregory M., Takeuchi, Masaaki, Tsang, Wendy, Tucay, Edwin S., Tude Rodrigues, Ana Clara, Vivekanandan, Amuthan, Zhang, Yun, Ferkh, Aaisha, Pathan, Faraz, Kizana, Eddy, Elhindi, James, Singh, Amita, Singulane, Cristiane Carvalho, Miyoshi, Tatsuya, Asch, Federico M., Lang, Roberto M., and Thomas, Liza

Published
2023
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21. Chlorhexidine gluconate bathing in children with cancer or those undergoing hematopoietic stem cell transplantation: A double‐blinded randomized controlled trial from the Children's Oncology Group

Author

Zerr, Danielle M, Milstone, Aaron M, Dvorak, Christopher C, Adler, Amanda L, Chen, Lu, Villaluna, Doojduen, Dang, Ha, Qin, Xuan, Addetia, Amin, Yu, Lolie C, Keller, Mary Conway, Esbenshade, Adam J, August, Keith J, Fisher, Brian T, and Sung, Lillian

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cancer, Clinical Trials and Supportive Activities, Clinical Research, Pediatric, Transplantation, Pediatric Cancer, Hematology, Sepsis, Adolescent, Anti-Infective Agents, Local, Child, Child, Preschool, Chlorhexidine, Double-Blind Method, Hematopoietic Stem Cell Transplantation, Humans, Infant, Neoplasms, Transplantation Conditioning, Young Adult, bacteremia, central line-associated bloodstream infection, chlorhexidine gluconate, Multi-drug resistant organisms, multi-drug resistant organisms, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis, Public health
Abstract

BackgroundTo the authors' knowledge, information regarding whether daily bathing with chlorhexidine gluconate (CHG) reduces central line-associated bloodstream infection (CLABSI) in pediatric oncology patients and those undergoing hematopoietic stem cell transplantation (HCT) is limited.MethodsIn the current multicenter, randomized, double-blind, placebo-controlled trial, patients aged ≥2 months and

Published
2021

23. Regulatory T cell-like response to SARS-CoV-2 in Jamaican fruit bats (Artibeus jamaicensis) transduced with human ACE2.

Author

Bradly Burke, Savannah M Rocha, Shijun Zhan, Miles Eckley, Clara Reasoner, Amin Addetia, Juliette Lewis, Anna Fagre, Phillida A Charley, Juergen A Richt, Susan R Weiss, Ronald B Tjalkens, David Veesler, Tawfik Aboellail, and Tony Schountz

Subjects
Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5
Abstract

Insectivorous Old World horseshoe bats (Rhinolophus spp.) are the likely source of the ancestral SARS-CoV-2 prior to its spillover into humans and causing the COVID-19 pandemic. Natural coronavirus infections of bats appear to be principally confined to the intestines, suggesting fecal-oral transmission; however, little is known about the biology of SARS-related coronaviruses in bats. Previous experimental challenges of Egyptian fruit bats (Rousettus aegyptiacus) resulted in limited infection restricted to the respiratory tract, whereas insectivorous North American big brown bats (Eptesicus fuscus) showed no evidence of infection. In the present study, we challenged Jamaican fruit bats (Artibeus jamaicensis) with SARS-CoV-2 to determine their susceptibility. Infection was confined to the intestine for only a few days with prominent viral nucleocapsid antigen in epithelial cells, and mononuclear cells of the lamina propria and Peyer's patches, but with no evidence of infection of other tissues; none of the bats showed visible signs of disease or seroconverted. Expression levels of ACE2 were low in the lungs, which may account for the lack of pulmonary infection. Bats were then intranasally inoculated with a replication-defective adenovirus encoding human ACE2 and 5 days later challenged with SARS-CoV-2. Viral antigen was prominent in lungs for up to 14 days, with loss of pulmonary cellularity during this time; however, the bats did not exhibit weight loss or visible signs of disease. From day 7, bats had low to moderate IgG antibody titers to spike protein by ELISA, and one bat on day 10 had low-titer neutralizing antibodies. CD4+ helper T cells became activated upon ex vivo recall stimulation with SARS-CoV-2 nucleocapsid peptide library and exhibited elevated mRNA expression of the regulatory T cell cytokines interleukin-10 and transforming growth factor-β, which may have limited inflammatory pathology. Collectively, these data show that Jamaican fruit bats are poorly susceptible to SARS-CoV-2 but that expression of human ACE2 in their lungs leads to robust infection and an adaptive immune response with low-titer antibodies and a regulatory T cell-like response that may explain the lack of prominent inflammation in the lungs. This model will allow for insight of how SARS-CoV-2 infects bats and how bat innate and adaptive immune responses engage the virus without overt clinical disease.

Published
2023
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24. Variations in indexation of left atrial volume across different races

Author

Aaisha Ferkh, Faraz Pathan, Eddy Kizana, James Elhindi, Amita Singh, Cristiane Carvalho Singulane, Tatsuya Miyoshi, Federico M. Asch, Roberto M. Lang, Liza Thomas, Aldo D. Prado, Karima Addetia, Michele Bellino, Masao Daimon, Pedro Gutierrez Fajardo, Ravi R. Kasliwal, James N. Kirkpatrick, Mark J. Monaghan, Denisa Muraru, Kofo O. Ogunyankin, Seung Woo Park, Ricardo E. Ronderos, Anita Sadeghpour, Gregory M. Scalia, Masaaki Takeuchi, Wendy Tsang, Edwin S. Tucay, Ana Clara Tude Rodrigues, Amuthan Vivekanandan, and Yun Zhang

Subjects
Left atrial volume, Echocardiography, Body surface area, Allometric indexation, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Background: Left atrial volume (LAV) has prognostic value. Guidelines propose indexation to body surface area (BSA), however studies demonstrate this can overcorrect for body size. Limited studies investigate indexation across different ethnicities. We sought to evaluate the effect of ethnicity on indexation. Methods: Using data from the World Alliance of Societies of Echocardiography (WASE) cohort, healthy subjects were classified by race as White, Black, Asian, or Other. Biplane LAV was indexed to traditional isometric measurements (BSA, height, weight, ideal body weight (IBW) and IBW derived BSA (IBSA)), as well as previously-derived allometric height exponents (2.7 and 1.72). Additionally, an allometric height exponent for our cohort was derived (linear regression of the logarithmic transformation of LAV = a(height)b) as 1.87. All indices were then assessed using Spearman correlation, with a good index retaining correlation of LAV/index to raw LAV (r∼1), while avoiding overcorrection by the index (r∼0). Results: There were 1366 subjects (White: 524, Black: 149, Asian: 523, Other: 170; median age 44 years, 653 females (47.8%)). In the entire group, BSA, IBSA, height1.87 and height1.72 performed well with retaining correlation to raw LAV (r > 0.9 for all), and minimising overcorrection to body size (r

Published
2023
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25. Normal Values of Three-Dimensional Right Ventricular Size and Function Measurements: Results of the World Alliance Societies of Echocardiography Study

Author

Prado, Aldo D., Filipini, Eduardo, Kwon, Agatha, Hoschke-Edwards, Samantha, Afonso, Tania Regina, Thampinathan, Babitha, Sooriyakanthan, Maala, Zhu, Tiangang, Wang, Zhilong, Wang, Yingbin, Yin, Lixue, Li, Shuang, Alagesan, R., Balasubramanian, S., Ananth, R.V.A., Bansal, Manish, Badano, Luigi, Bossone, Eduardo, Di Vece, Davide, Bellino, Michele, Nakao, Tomoko, Kawata, Takayuki, Hirokawa, Megumi, Sawada, Naoko, Nabeshima, Yousuke, Yun, Hye Rim, Hwang, Ji-won, Addetia, Karima, Miyoshi, Tatsuya, Amuthan, Vivekanandan, Citro, Rodolfo, Daimon, Masao, Gutierrez Fajardo, Pedro, Kasliwal, Ravi R., Kirkpatrick, James N., Monaghan, Mark J., Muraru, Denisa, Ogunyankin, Kofo O., Park, Seung Woo, Ronderos, Ricardo E., Sadeghpour, Anita, Scalia, Gregory M., Takeuchi, Masaaki, Tsang, Wendy, Tucay, Edwin S., Tude Rodrigues, Ana Clara, Zhang, Yun, Singulane, Cristiane C., Hitschrich, Niklas, Blankenhagen, Michael, Degel, Markus, Schreckenberg, Marcus, Mor-Avi, Victor, Asch, Federico M., and Lang, Roberto M.

Published
2023
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26. Chlorhexidine gluconate bathing in children with cancer or those undergoing hematopoietic stem cell transplantation: A double-blinded randomized controlled trial from the Children's Oncology Group.

Author

Zerr, Danielle M, Milstone, Aaron M, Dvorak, Christopher C, Adler, Amanda L, Chen, Lu, Villaluna, Doojduen, Dang, Ha, Qin, Xuan, Addetia, Amin, Yu, Lolie C, Conway Keller, Mary, Esbenshade, Adam J, August, Keith J, Fisher, Brian T, and Sung, Lillian

Subjects
bacteremia, central line-associated bloodstream infection, chlorhexidine gluconate, multi-drug resistant organisms, Multi-drug resistant organisms, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis
Abstract

BackgroundTo the authors' knowledge, information regarding whether daily bathing with chlorhexidine gluconate (CHG) reduces central line-associated bloodstream infection (CLABSI) in pediatric oncology patients and those undergoing hematopoietic stem cell transplantation (HCT) is limited.MethodsIn the current multicenter, randomized, double-blind, placebo-controlled trial, patients aged ≥2 months and

Published
2020

28. Abstract 18186: Four Chambers Strain Analysis in Patients Admitted With Acute Heart Failure: A New Characterization of Heart Involvement?

Author

Soulat-Dufour, Laurie, Bourai, Ania, Lang, Sylvie, Capderou, Elodie, EDERHY, Stephane, ADAVANE, Saroumadi, Chauvet-Droit, Marion, Arnaud, Camille, Issaurat, Pauline, Jullien, Stéphanie, Cardoso, Chloé, Gerard, Manon, Cherif, Ghassen, Addetia, Karima, Boccara, Franck, Assyag, Patrick, Lang, Roberto, and Cohen, Ariel

Published
2023
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29. Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection

Author

Olivier Reynard, Claudia Gonzalez, Claire Dumont, Mathieu Iampietro, Marion Ferren, Sandrine Le Guellec, Lajoie Laurie, Cyrille Mathieu, Gabrielle Carpentier, Georges Roseau, Francesca T. Bovier, Yun Zhu, Deborah Le Pennec, Jérome Montharu, Amin Addetia, Alexander L. Greninger, Christopher A. Alabi, Elise Brisebard, Anne Moscona, Laurent Vecellio, Matteo Porotto, and Branka Horvat

Subjects
Science
Abstract

Despite the availability of a safe and effective vaccine, measles remains the leading cause of child death among vaccine-preventable diseases. In this work, authors utilised a cynomolgus macaque model of infection, and a mesh nebuliser administration approach, to show efficacy of their aerosolized lipopeptide fusion inhibitor against the measles virus.

Published
2022
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30. Structural changes in the SARS-CoV-2 spike E406W mutant escaping a clinical monoclonal antibody cocktail

Author

Amin Addetia, Young-Jun Park, Tyler Starr, Allison J. Greaney, Kaitlin R. Sprouse, John E. Bowen, Sasha W. Tiles, Wesley C. Van Voorhis, Jesse D. Bloom, Davide Corti, Alexandra C. Walls, and David Veesler

Subjects
CP: Immunology, CP: Microbiology, Biology (General), QH301-705.5
Abstract

Summary: Continued evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is eroding antibody responses elicited by prior vaccination and infection. The SARS-CoV-2 receptor-binding domain (RBD) E406W mutation abrogates neutralization mediated by the REGEN-COV therapeutic monoclonal antibody (mAb) COVID-19 cocktail and the AZD1061 (COV2-2130) mAb. Here, we show that this mutation remodels the receptor-binding site allosterically, thereby altering the epitopes recognized by these three mAbs and vaccine-elicited neutralizing antibodies while remaining functional. Our results demonstrate the spectacular structural and functional plasticity of the SARS-CoV-2 RBD, which is continuously evolving in emerging SARS-CoV-2 variants, including currently circulating strains that are accumulating mutations in the antigenic sites remodeled by the E406W substitution.

Published
2023
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31. Human versus Artificial Intelligence–Based Echocardiographic Analysis as a Predictor of Outcomes: An Analysis from the World Alliance Societies of Echocardiography COVID Study

Author

Munoz, Vince Ryan V., De Marchi, Rafael Porto, Alday-Ramirez, Sergio M., Orihuela, Consuelo, Sadeghpour, Anita, Breeze, Jonathan, Hoare, Amy, Rosales, Carlos Ixcanparij, Cohen, Ariel, Milani, Martina, Trolese, Ilaria, Belli, Oriana, De Chiara, Benedetta, Bellino, Michele, Iuliano, Giuseppe, Yang, Yun, Asch, Federico M., Descamps, Tine, Sarwar, Rizwan, Karagodin, Ilya, Singulane, Cristiane Carvalho, Xie, Mingxing, Tucay, Edwin S., Tude Rodrigues, Ana C., Vasquez-Ortiz, Zuilma Y., Monaghan, Mark J., Ordonez Salazar, Bayardo A., Soulat-Dufour, Laurie, Alizadehasl, Azin, Mostafavi, Atoosa, Moreo, Antonella, Citro, Rodolfo, Narang, Akhil, Wu, Chun, Addetia, Karima, Upton, Ross, Woodward, Gary M., and Lang, Roberto M.

Published
2022
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34. Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection

Author

Reynard, Olivier, Gonzalez, Claudia, Dumont, Claire, Iampietro, Mathieu, Ferren, Marion, Le Guellec, Sandrine, Laurie, Lajoie, Mathieu, Cyrille, Carpentier, Gabrielle, Roseau, Georges, Bovier, Francesca T., Zhu, Yun, Le Pennec, Deborah, Montharu, Jérome, Addetia, Amin, Greninger, Alexander L., Alabi, Christopher A., Brisebard, Elise, Moscona, Anne, Vecellio, Laurent, Porotto, Matteo, and Horvat, Branka

Published
2022
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35. Host–pathogen dynamics in longitudinal clinical specimens from patients with COVID-19

Author

Michelle J. Lin, Victoria M. Rachleff, Hong Xie, Lasata Shrestha, Nicole A. P. Lieberman, Vikas Peddu, Amin Addetia, Amanda M. Casto, Nathan Breit, Patrick C. Mathias, Meei-Li Huang, Keith R. Jerome, Alexander L. Greninger, and Pavitra Roychoudhury

Subjects
Medicine, Science
Abstract

Abstract Rapid dissemination of SARS-CoV-2 sequencing data to public repositories has enabled widespread study of viral genomes, but studies of longitudinal specimens from infected persons are relatively limited. Analysis of longitudinal specimens enables understanding of how host immune pressures drive viral evolution in vivo. Here we performed sequencing of 49 longitudinal SARS-CoV-2-positive samples from 20 patients in Washington State collected between March and September of 2020. Viral loads declined over time with an average increase in RT-QPCR cycle threshold of 0.87 per day. We found that there was negligible change in SARS-CoV-2 consensus sequences over time, but identified a number of nonsynonymous variants at low frequencies across the genome. We observed enrichment for a relatively small number of these variants, all of which are now seen in consensus genomes across the globe at low prevalence. In one patient, we saw rapid emergence of various low-level deletion variants at the N-terminal domain of the spike glycoprotein, some of which have previously been shown to be associated with reduced neutralization potency from sera. In a subset of samples that were sequenced using metagenomic methods, differential gene expression analysis showed a downregulation of cytoskeletal genes that was consistent with a loss of ciliated epithelium during infection and recovery. We also identified co-occurrence of bacterial species in samples from multiple hospitalized individuals. These results demonstrate that the intrahost genetic composition of SARS-CoV-2 is dynamic during the course of COVID-19, and highlight the need for continued surveillance and deep sequencing of minor variants.

Published
2022
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40. Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV

Author

Chao, Cara W., primary, Sprouse, Kaitlin R., additional, Miranda, Marcos C., additional, Catanzaro, Nicholas J., additional, Hubbard, Miranda L., additional, Addetia, Amin, additional, Stewart, Cameron, additional, Brown, Jack T., additional, Dosey, Annie, additional, Valdez, Adian, additional, Ravichandran, Rashmi, additional, Hendricks, Grace G., additional, Ahlrichs, Maggie, additional, Dobbins, Craig, additional, Hand, Alexis, additional, Treichel, Catherine, additional, Willoughby, Isabelle, additional, Walls, Alexandra C., additional, McGuire, Andrew T., additional, Leaf, Elizabeth M., additional, Baric, Ralph S., additional, Schäfer, Alexandra, additional, Veesler, David, additional, and King, Neil P., additional

Published
2024
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42. Broad sarbecovirus neutralization by a human monoclonal antibody

Author

Tortorici, M. Alejandra, Czudnochowski, Nadine, Starr, Tyler N., Marzi, Roberta, Walls, Alexandra C., Zatta, Fabrizia, Bowen, John E., Jaconi, Stefano, Di Iulio, Julia, Wang, Zhaoqian, De Marco, Anna, Zepeda, Samantha K., Pinto, Dora, Liu, Zhuoming, Beltramello, Martina, Bartha, Istvan, Housley, Michael P., Lempp, Florian A., Rosen, Laura E., Dellota, Jr, Exequiel, Kaiser, Hannah, Montiel-Ruiz, Martin, Zhou, Jiayi, Addetia, Amin, Guarino, Barbara, Culap, Katja, Sprugasci, Nicole, Saliba, Christian, Vetti, Eneida, Giacchetto-Sasselli, Isabella, Fregni, Chiara Silacci, Abdelnabi, Rana, Foo, Shi-Yan Caroline, Havenar-Daughton, Colin, Schmid, Michael A., Benigni, Fabio, Cameroni, Elisabetta, Neyts, Johan, Telenti, Amalio, Virgin, Herbert W., Whelan, Sean P. J., Snell, Gyorgy, Bloom, Jesse D., Corti, Davide, Veesler, David, and Pizzuto, Matteo Samuele

Published
2021
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44. Inactivation of genes in oxidative respiration and iron acquisition pathways in pediatric clinical isolates of Small colony variant Enterobacteriaceae

Author

Alexander L. Greninger, Amin Addetia, Yue Tao, Amanda Adler, and Xuan Qin

Subjects
Medicine, Science
Abstract

Abstract Isolation of bacterial small colony variants (SCVs) from clinical specimens is not uncommon and can fundamentally change the outcome of the associated infections. Bacterial SCVs often emerge with their normal colony phenotype (NCV) co-isolates in the same sample. The basis of SCV emergence in vivo is not well understood in Gram-negative bacteria. In this study, we interrogated the causal genetic lesions of SCV growth in three pairs of NCV and SCV co-isolates of Escherichia coli, Citrobacter freundii, and Enterobacter hormaechei. We confirmed SCV emergence was attributed to limited genomic mutations: 4 single nucleotide variants in the E. coli SCV, 5 in C. freundii, and 8 in E. hormaechei. In addition, a 10.2 kb chromosomal segment containing 11 genes was deleted in the E. hormaechei SCV isolate. Each SCV had at least one coding change in a gene associated with bacterial oxidative respiration and another involved in iron capture. Chemical and genetic rescue confirmed defects in heme biosynthesis for E. coli and C. freundii and lipoic acid biosynthesis in E. hormaachei were responsible for the SCV phenotype. Prototrophic growth in all 3 SCV Enterobacteriaceae species was unaffected under anaerobic culture conditions in vitro, illustrating how SCVs may persist in vivo.

Published
2021
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46. Organic Tricuspid Regurgitation

Author

Muraru, Denisa, Addetia, Karima, Jarjour, Fabiana, Lang, Roberto M., Badano, Luigi P., Badano, Luigi P., editor, Lang, Roberto M., editor, and Muraru, Denisa, editor

Published
2019
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49. The Normal Tricuspid Valve

Author

Addetia, Karima, Muraru, Denisa, Guta, Andrada-Camelia, Badano, Luigi P., Lang, Roberto M., Badano, Luigi P., editor, Lang, Roberto M., editor, and Muraru, Denisa, editor

Published
2019
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50. Developing Insights Regarding Tricuspid Valve Regurgitation: Morphology, Assessment of Severity, and the Need for a Novel Grading Scheme

Author

Cristiane Carvalho Singulane, MD, MSc, Amita Singh, MD, FACC, FASE, Karima Addetia, MD, FACC, FASE, Megan Yamat, ACS, RDCS, and Roberto Miguel Lang, MD, FASE, FACC

Subjects
Echocardiography, Three-dimensional echocardiography, Transesophageal echocardiography, Tricuspid valve, Tricuspid valve insufficiency, Tricuspid valve regurgitation grading, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Current understanding that progressive tricuspid regurgitation (TR) is associated with worse outcomes has highlighted the clinical need for a more accurate assessment of TR morphology and severity. This need has been further emphasized owing to the development of a myriad of percutaneous right-sided interventions, which may offer successful treatment of TR in selected patients. Understanding the etiology and quantification of the severity of TR has important implications in the selection of novel therapeutic strategies, i.e., medical vs. percutaneous vs. surgical approaches. Newer grading schemas that better reflect the TR lesion severity have been recently proposed and may facilitate monitoring of the evolution of TR following percutaneous and/or surgical treatment. In this review, we summarize contemporary concepts regarding tricuspid valve morphology, TR etiology, and associated mechanisms and echocardiographic approaches to grade TR severity.

Published
2022
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