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Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection

Authors :
Olivier Reynard
Claudia Gonzalez
Claire Dumont
Mathieu Iampietro
Marion Ferren
Sandrine Le Guellec
Lajoie Laurie
Cyrille Mathieu
Gabrielle Carpentier
Georges Roseau
Francesca T. Bovier
Yun Zhu
Deborah Le Pennec
Jérome Montharu
Amin Addetia
Alexander L. Greninger
Christopher A. Alabi
Elise Brisebard
Anne Moscona
Laurent Vecellio
Matteo Porotto
Branka Horvat
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Despite the availability of a safe and effective vaccine, measles remains the leading cause of child death among vaccine-preventable diseases. In this work, authors utilised a cynomolgus macaque model of infection, and a mesh nebuliser administration approach, to show efficacy of their aerosolized lipopeptide fusion inhibitor against the measles virus.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.13c3e6d63c6498493bb10874ac6bd5d
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-33832-6