157 results on '"Adam-Blondon, Anne-Françoise"'
Search Results
2. Enabling reusability of plant phenomic datasets with MIAPPE 1.1
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Papoutsoglou, Evangelia A., Faria, Daniel, Arend, Daniel, Arnaud, Elizabeth, Athanasiadis, Ioannis N., Chaves, Inês, Coppens, Frederik, Cornut, Guillaume, Costa, Bruno V., Ćwiek-Kupczyńska, Hanna, Droesbeke, Bert, Finkers, Richard, Gruden, Kristina, Junker, Astrid, King, Graham J., Krajewski, Paweł, Lange, Matthias, Laporte, Marie-Angélique, Michotey, Célia, Oppermann, Markus, Ostler, Richard, Poorter, Hendrik, Ramırez-Gonzalez, Ricardo, Ramšak, Živa, Reif, Jochen C., Rocca-Serra, Philippe, Sansone, Susanna-Assunta, Scholz, Uwe, Tardieu, François, Uauy, Cristobal, Usadel, Björn, Visser, Richard G. F., Weise, Stephan, Kersey, Paul J., Miguel, Célia M., Adam-Blondon, Anne-Françoise, and Pommier, Cyril
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- 2020
3. The grapevine gene nomenclature system.
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Grimplet, Jérôme, Adam-Blondon, Anne-Françoise, Bert, Pierre-François, Bitz, Oliver, Cantu, Dario, Davies, Christopher, Delrot, Serge, Pezzotti, Mario, Rombauts, Stéphane, and Cramer, Grant R
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Vitis ,Plant Proteins ,Computational Biology ,Phylogeny ,Genome ,Plant ,Algorithms ,Molecular Sequence Annotation ,Genome ,Plant ,Bioinformatics ,Biological Sciences ,Medical and Health Sciences ,Information and Computing Sciences - Abstract
BackgroundGrapevine (Vitis vinifera L.) is one of the most important fruit crops in the world and serves as a valuable model for fruit development in woody species. A major breakthrough in grapevine genomics was achieved in 2007 with the sequencing of the Vitis vinifera cv. PN40024 genome. Subsequently, data on structural and functional characterization of grape genes accumulated exponentially. To better exploit the results obtained by the international community, we think that a coordinated nomenclature for gene naming in species with sequenced genomes is essential. It will pave the way for the accumulation of functional data that will enable effective scientific discussion and discovery. The exploitation of data that were generated independently of the genome release is hampered by their heterogeneous nature and by often incompatible and decentralized storage. Classically, large amounts of data describing gene functions are only available in printed articles and therefore remain hardly accessible for automatic text mining. On the other hand, high throughput "Omics" data are typically stored in public repositories, but should be arranged in compendia to better contribute to the annotation and functional characterization of the genes.ResultsWith the objective of providing a high quality and highly accessible annotation of grapevine genes, the International Grapevine Genome Project (IGGP) commissioned an international Super-Nomenclature Committee for Grape Gene Annotation (sNCGGa) to coordinate the effort of experts to annotate the grapevine genes. The goal of the committee is to provide a standard nomenclature for locus identifiers and to define conventions for a gene naming system in this paper.ConclusionsLearning from similar initiatives in other plant species such as Arabidopsis, rice and tomato, a versatile nomenclature system has been developed in anticipation of future genomic developments and annotation issues. The sNCGGa's first outreach to the grape community has been focused on implementing recommended guidelines for the expert annotators by: (i) providing a common annotation platform that enables community-based gene curation, (ii) developing a gene nomenclature scheme reflecting the biological features of gene products that is consistent with that used in other organisms in order to facilitate comparative analyses.
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- 2014
4. Palaeogenomic insights into the origins of French grapevine diversity
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Ramos-Madrigal, Jazmín, Runge, Anne Kathrine Wiborg, Bouby, Laurent, Lacombe, Thierry, Samaniego Castruita, José Alfredo, Adam-Blondon, Anne-Françoise, Figueiral, Isabel, Hallavant, Charlotte, Martínez-Zapater, José M., Schaal, Caroline, Töpfer, Reinhard, Petersen, Bent, Sicheritz-Pontén, Thomas, This, Patrice, Bacilieri, Roberto, Gilbert, M. Thomas P., and Wales, Nathan
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- 2019
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5. ELIXIR-CONVERGE D5.5 Report on the remaining four DMP processes
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Portell-Silva, Laura, Haurheeram, Vanita, Adam-Blondon, Anne-Françoise, Capella-Gutierrez, Salvador, Popleteeva, Marina, Bianchini, Federico, Åberg, Espen, Hooft, Rob, Schuánek, Marek, Slifka, Jan, Hospital, Adam, Willassen, Nils-Peder, Piñero, Janet, Sanz, Ferran, Ramirez-Anguita, Juan Manuel, Pastor, Manuel, Angel Mayer, Miguel, Picardi, Ernesto, Alper, Pinar, Ded, Vilém, Djenaba Barry, Nene, Lieby, Paulette, D'Altri, Teresa, Faria, Daniel, Le Floch, Erwin, Rocca-Serra, Philippe, Droesbeke, Bert, Bösl, Korbinian, Vidak, Marko, Pommier, Cyril, Beier, Sebastian, Lange, Matthias, Arend, Daniel, Zlender, Nadja, and Alic, Isabelle
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RDMKit ,DMPs ,ELIXIR-CONVERGE ,Data Management Plans ,ELIXIR ,Data Management - Abstract
The main objective of this deliverable is to provide resources that can assist life sciences researchers and data stewards in creating reference Data Management Plans (DMPs) for their research projects. The resources provided in this deliverable are intended to promote good research data management practices across the EU research landscape. To achieve this objective, a range of activities were undertaken, with a particular focus on the needs of the different domains covered by the demonstrator use-cases. In order to create these resources, the RDMkit pages were extended to include domain-specific information, which can be used as a reference when developing DMPs for different research projects. These pages fall under the "Your Domain" category and provide specific information on the data management needs and considerations for each domain. They also highlight challenges that are specific to each domain, such as data types, species, or areas, and offer solutions and considerations to overcome these challenges. In this deliverable, the RDMkit page for the Toxicology data demonstrator use-case was completed and added to the existing RDMkit pages for the other demonstrator use-cases. Additionally, a new Tool Assembly was added to the RDMkit corresponding to the Plant Sciences demonstrator use-case, covering the entire life cycle of experimental plant phenotyping data. In addition, the general Knowledge Models (KMs) of the Data Stewardship Wizard (DSW) were adapted to address the specific DMP questions needed for each demonstrator use-case. The DSW is a collaborative tool that enables data stewards and researchers to efficiently create DMPs for their research projects and it is designed with a hierarchical KM that guides users through the creation of DMPs. Since the relevant information for DMPs can vary across different domains, these KMs can be modified to contain the information relevant for each demonstrator use-case. For this deliverable, special focus was put on two of the demonstrator use-cases, namely Toxicology and Epitranscriptomics data. Additionally, related to the Human Data use-case, separate efforts are underway to enhance the sensitive data section of the KM system to ensure the proper management of such data. The improvements and new question suggestions that were found during these sessions were incorporated into the DSW KM by the DSW team. Furthermore, DMP templates were created in DSW for the demonstrator use-case using two standard approaches: creating a KM or a project template (PT). When creating a PT, a set of answers is saved and can be used to generate a partially pre-filled questionnaire for a new project. In the ideal case scenario, the two methods can be used together to provide domain-specific recommendations by answering questions that better reflect a scientific domain, such as metadata standards. In conclusion, this deliverable provides several valuable resources for life sciences researchers and data stewards, including extended RDMkit pages, customised DSW KMs, domain-specific DMP templates, and a new KM for creating DPIAs. These resources are designed to encourage good research data management practices across the EU research landscape, ensuring that valuable research data is effectively managed before, during, and after a project.
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- 2023
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6. ELIXIR-CONVERGE D5.4 Report on KPI
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Adam-Blondon, Anne-Françoise, Portell-Silva, Laura, Capella-Gutierrez, Salvador, Popleteeva, Marina, Jonassen, Inge, Bianchini, Federico, Åberg, Espen, Hospital, Adam, Willassen, Nils-Peder, Sanz, Ferran, Picardi, Ernesto, Alper, Pinar, Ded, Vilém, Djenaba Barry, Nene, d'Altri, Teresa, Vidak, Marco, and Martin, Corinne
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DMPs ,ELIXIR-CONVERGE ,Data Management Plans ,ELIXIR ,KPI - Abstract
The overall goal of ELIXIR-CONVERGE’s WP5 was, based on the analysis of a set of very diverse use cases, to contribute to the development of a set of resources supporting the development and implementation of Data Management Plans (DMPs) in national and transnational projects. Six use cases were considered to co-develop and test a method to address domain specific data management planning associated to a set of resources in collaboration with WP1, WP2 and WP3. In this context, another objective of WP5 was to develop, implement and refine key performance indicators (KPIs) in order to monitor the demonstrator projects’ implementation of data management plans and possibly assess their adoption by the relevant community. WP5 developed two sets KPIs in collaboration with WP4, in charge of developing KPIs across the entire ELIXIR-CONVERGE project and for assessing the impact of the project : a first set aiming at monitoring the development of guidance, resources for the development of DMP and for training in the context of the use cases a second set aiming at addressing the adoption of these resources by relevant communities of users as a way to assess the impact of the work achieved In parallel, in order to ensure long term maintenance/update of the developed resources and to increase their impact, WP5 started to engage with ELIXIR communities that could be natural owners of these resources. The KPI developed and collected by WP5 during the ELIXIR-CONVERGE project were useful to follow the partner’s progress in the development and test of a sort of starter kit for domain specific data management support. Success stories could be collected showing adoption by communities and new projects and were mapped on ELIXIR’s categories of impacts showing already “hits” on several of these.
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- 2023
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7. The ELIXIR Biodiversity Community: Understanding short- and long-term changes in biodiversity
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Waterhouse, Robert M., primary, Adam-Blondon, Anne-Françoise, additional, Balech, Bachir, additional, Barta, Endre, additional, Heil, Katharina F., additional, Hughes, Graham M., additional, Jermiin, Lars S., additional, Kalaš, Matúš, additional, Lanfear, Jerry, additional, Pafilis, Evangelos, additional, Papageorgiou, Aristotelis C., additional, Psomopoulos, Fotis, additional, Raes, Niels, additional, Burgin, Josephine, additional, and Gabaldón, Toni, additional
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- 2023
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8. ELIXIR-CONVERGE D5.3 Report on the dedicated training and capacity building activities
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Leskošek, Brane, Haurheeram, Vanita, Bianchini, Federico, Alper, Pinar, Portell-Silva, Laura, Åberg, Espen, Hospital, Adam, Popleteeva, Marina, Willassen, Nils P, Vidak, Marko, Adam-Blondon, Anne-Françoise, Collin, Olivier, Curwin, Amy, Freeberg, Mallory, Le Floch, Erwan, Lieby, Paulette, Picardi, Ernesto, and Capella-Gutierrez, Salvador
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Capacity building ,Training ,ELIXIR-CONVERGE ,ELIXIR - Abstract
One of the objectives of WP5 was to identify the needs in terms of capacity building, in the context of the 6 use cases, and to develop strategy(ies) in collaboration with WP2 to address these needs. This was achieved in three steps: Create an inventory of training resources available in the context of the use cases Send an online survey followed by a series of F2F meetings with each use case to collect their training needs Test the development of learning paths as a method to develop a structured overview of training needs in relation to a use case The method set up by the ELIXIR Training Platform to better structure the development of training resources was proved very helpful to specify the needs in terms of training and capacity building in the context of the use cases. Spelling out the priority in terms of training target and the learning path to follow to reach this target is a way to detail the different modules that are necessary. It is then possible to map on these modules the training resources that are already available and to derive a list of gaps. This method was applied for three demo cases successfully in the Plant, Marine metagenomics and Human Genome data contexts. In terms of general organisation of community resources to facilitate this type of approach, the most important actions are to make the training materials accessible for reuse and easy to find. Versioning is highly desirable, to facilitate collaborative development and maintenance of training material of the time and a DOI attribution will facilitate citation and long term findability. Findability requires additional work to organise the training events and training resources in categories and/or facilitate filtering in the context of catalogues of training resources such as TeSS or Glittr or of knowledge hubs such as the RDMkit. This is achieved in TeSS, through the annotation of the training material and linked training events with ontology terms from EDAM, as well as with custom keywords.  
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- 2023
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9. RepetDB: a unified resource for transposable element references
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Amselem, Joëlle, Cornut, Guillaume, Choisne, Nathalie, Alaux, Michael, Alfama-Depauw, Françoise, Jamilloux, Véronique, Maumus, Florian, Letellier, Thomas, Luyten, Isabelle, Pommier, Cyril, Adam-Blondon, Anne-Françoise, and Quesneville, Hadi
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- 2019
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10. SyntenyViewer: a comparative genomics-driven translational research tool
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Flores, Raphael, primary, Huneau, Cécile, additional, Burlot, Laura, additional, Lainé, Mathilde, additional, Kimmel, Erik, additional, Pommier, Cyril, additional, Alaux, Michael, additional, Adam-Blondon, Anne-Françoise, additional, Pont, Caroline, additional, Quesneville, Hadi, additional, and Salse, Jerome, additional
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- 2023
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11. A social–ecological approach to managing multiple agro-ecosystem services
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Lescourret, Françoise, Magda, Danièle, Richard, Guy, Adam-Blondon, Anne-Françoise, Bardy, Marion, Baudry, Jacques, Doussan, Isabelle, Dumont, Bertrand, Lefèvre, François, Litrico, Isabelle, Martin-Clouaire, Roger, Montuelle, Bernard, Pellerin, Sylvain, Plantegenest, Manuel, Tancoigne, Elise, Thomas, Alban, Guyomard, Hervé, and Soussana, Jean-François
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- 2015
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12. Linking the International Wheat Genome Sequencing Consortium bread wheat reference genome sequence to wheat genetic and phenomic data
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Alaux, Michael, Rogers, Jane, Letellier, Thomas, Flores, Raphaël, Alfama, Françoise, Pommier, Cyril, Mohellibi, Nacer, Durand, Sophie, Kimmel, Erik, Michotey, Célia, Guerche, Claire, Loaec, Mikaël, Lainé, Mathilde, Steinbach, Delphine, Choulet, Frédéric, Rimbert, Hélène, Leroy, Philippe, Guilhot, Nicolas, Salse, Jérôme, Feuillet, Catherine, International Wheat Genome Sequencing Consortium, Paux, Etienne, Eversole, Kellye, Adam-Blondon, Anne-Françoise, and Quesneville, Hadi
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- 2018
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13. Survey of information systems and web services useful for the grapevine community - Gaps and Recommendations
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ADAM-BLONDON, Anne-Françoise, ALAUX, Michael, GRIMPLET, Jérôme, HOLTGRAEWE, Daniela, KERSEY, Paul, MATUS, José Tomas, MORETTO, Marco, PEZZOTTI, Mario, PILATI, Stefania, RUSTENHOLZ, Camille, TOEPFER, Reinhard, and VELT, Amandine
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Database, data access, API, grapevine - Abstract
The international grapevine community has been working for a decade on recommendations and best practices to facilitate data exchange and reuse. Its first activity consisted in the development of a nomenclature system for grapevine genes that would allow consistent gene naming. The second was to propose a strategy aiming at facilitation grapevine data findability and reuse through recommendation on metadata standards, identifiers associated to samples which use will in turn facilitate the development of a centralized search tool across a federation of databases. The aim of the network was to make a step forward towards the implementation of this strategy by working on the three complementary pillars of success: improvement of the standards, ontologies and of guidelines for FAIR data management necessary to the grapevine community dissemination and training on these guidelines development of a federation of databases holding grapevine data, sharing the same metadata standards and identifiers, being all searchable through the same central portal and allowing data access and reuse. The first objective of this document is to set up the scene of the third pillar described above by: identifying the databases/information systems frequently used by the grapevine community checking how data (including metadata) can be accessed from these information systems Identifying possible problems and gaps The second objective is to make recommendations on steps to move forward towards the building of a federation of databases that would collaborate to provide central data services to the grapevine research community., This deliverable was developed upon work from COST Action CA 17111 INTEGRAPE, supported by COST (European Cooperation in Science and Technology).
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- 2022
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14. Research Data Management Toolkit (RDMkit): guidelines for plant phenotyping data management and sharing
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Floch, Erwan Le, Adam-Blondon, Anne-Françoise, Alic, Isabelle, Droesbeke, Bert, Dhondt, Stijn, Faria, Daniel, Beier, Sebastian, Neveu, Pascal, Francillonne, Nicolas, Michotey, Célia, Pommier, Cyril, Université Paris-Saclay, INRAE, BioinfOmics, Plant Bioinformatics Facility, Versailles, France (BioinfOmics, Plant Bioinformatics Facility), Unité de Recherche Génomique Info (URGI), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Mathématiques, Informatique et STatistique pour l'Environnement et l'Agronomie (MISTEA), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), VIBUGent Center for Plant Systems Biology, Universiteit Gent = Ghent University (UGENT), LaSIGE [Lisboa], Universidade de Lisboa = University of Lisbon (ULISBOA)-Faculdade de Ciências, BioData.pt, Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal, Institute of Bio- and Geosciences [Jülich] (IBG), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association-Helmholtz-Gemeinschaft = Helmholtz Association, IPPN, European Project: 862613,H2020-AGENT, and European Project: 871075,ELIXIR-CONVERGE
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FAIR data ,RDMkit ,Research data management ,[SDV.BV]Life Sciences [q-bio]/Vegetal Biology ,[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] ,Plant phenomics ,Plant phenotyping - Abstract
Efficient sharing of plant phenotyping data is a challenge that has been addressed during the last two decades by European infrastructures (ELIXIR, EMPHASIS) and international communities (CGIAR), that allowed to coordinate the effort of major institutes developing activities in the domain. They produced consistent and interoperable sets of resources to support plant phenotyping data management: - data standards: Minimum Information About Plant Phenotyping Experiment (MIAPPE) and the Breeding API (BrAPI) - databases: PIPPA, PHIS, GnpIS, e!DAL-PGP among others - exchange file formats: MIAPPE Template, ISA-Tab These systems and standards have been designed to be as close as possible to researchers and experimenters needs. As a consequence, important efforts have been made to ease their adoption through documentations and trainings. However all these resources remain dispersed, and it can be complicated for new users to know where to get the right information. To address this issue, ELIXIR has developed in the frame of the ELIXIR-CONVERGE project a central portal of guidelines and resources supporting FAIR data management in Life Sciences: the Research Data Management toolkit (RDMkit). RDMkit is a one stop portal that gives a general overview and understanding of the complementarity of the solutions, and links back to the extended documentation and training materials maintained for each of them. To develop and sustain this portal, ELIXIR has engaged with various communities, infrastructures and projects, among which the ELIXIR plant science community and the AGENT project. In the RDMkit, the plant community has built a set of pages and in particular is building plant phenotyping guidelines. The present poster gives an overview of the RDMkit logic and of the solutions presented in the plant sciences pages, including the procedures and contact to submit enrichment and additional solutions.
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- 2022
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15. Recommendations for connecting molecular sequence and biodiversity research infrastructures through ELIXIR
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Waterhouse, Robert M., Adam-Blondon, Anne-Françoise, Agosti, Donat, Baldrian, Petr, Balech, Bachir, Corre, Erwan, Davey, Robert P., Lantz, Henrik, Pesole, Graziano, Quast, Christian, Glöckner, Frank Oliver, Raes, Niels, Sandionigi, Anna, Santamaria, Monica, Addink, Wouter, Vohradsky, Jiri, Nunes-Jorge, Amandine, Willassen, Nils Peder, and Lanfear, Jerry
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General Pharmacology, Toxicology and Pharmaceutics ,General Immunology and Microbiology ,General Biochemistry, Genetics and Molecular Biology ,General Medicine - Abstract
Threats to global biodiversity are increasingly recognised by scientists and the public as a critical challenge. Molecular sequencing technologies offer means to catalogue, explore, and monitor the richness and biogeography of life on Earth. However, exploiting their full potential requires tools that connect biodiversity infrastructures and resources. As a research infrastructure developing services and technical solutions that help integrate and coordinate life science resources across Europe, ELIXIR is a key player. To identify opportunities, highlight priorities, and aid strategic thinking, here we survey approaches by which molecular technologies help inform understanding of biodiversity. We detail example use cases to highlight how DNA sequencing is: resolving taxonomic issues; Increasing knowledge of marine biodiversity; helping understand how agriculture and biodiversity are critically linked; and playing an essential role in ecological studies. Together with examples of national biodiversity programmes, the use cases show where progress is being made but also highlight common challenges and opportunities for future enhancement of underlying technologies and services that connect molecular and wider biodiversity domains. Based on emerging themes, we propose key recommendations to guide future funding for biodiversity research: biodiversity and bioinformatic infrastructures need to collaborate closely and strategically; taxonomic efforts need to be aligned and harmonised across domains; metadata needs to be standardised and common data management approaches widely adopted; current approaches need to be scaled up dramatically to address the anticipated explosion of molecular data; bioinformatics support for biodiversity research needs to be enabled and sustained; training for end users of biodiversity research infrastructures needs to be prioritised; and community initiatives need to be proactive and focused on enabling solutions. For sequencing data to deliver their full potential they must be connected to knowledge: together, molecular sequence data collection initiatives and biodiversity research infrastructures can advance global efforts to prevent further decline of Earth's biodiversity.
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- 2022
16. Recommendations for connecting molecular sequence and biodiversity research infrastructures through ELIXIR
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Waterhouse, Robert M., primary, Adam-Blondon, Anne-Françoise, additional, Agosti, Donat, additional, Baldrian, Petr, additional, Balech, Bachir, additional, Corre, Erwan, additional, Davey, Robert P., additional, Lantz, Henrik, additional, Pesole, Graziano, additional, Quast, Christian, additional, Glöckner, Frank Oliver, additional, Raes, Niels, additional, Sandionigi, Anna, additional, Santamaria, Monica, additional, Addink, Wouter, additional, Vohradsky, Jiri, additional, Nunes-Jorge, Amandine, additional, Willassen, Nils Peder, additional, and Lanfear, Jerry, additional
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- 2022
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17. Recommendations for connecting molecular sequence and biodiversity research infrastructures through ELIXIR
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Waterhouse, Robert M, Adam-Blondon, Anne-Françoise, Agosti, Donat, Baldrian, Petr, Balech, Bachir, Corre, Erwan, Davey, Robert P, Lantz, Henrik, Pesole, Graziano, Quast, Christian, Glöckner, Frank Oliver, Raes, Niels, Sandionigi, Anna, Santamaria, Monica, Addink, Wouter, Vohradsky, Jiri, Nunes-Jorge, Amandine, Willassen, Nils Peder, Lanfear, Jerry, Waterhouse, Robert M, Adam-Blondon, Anne-Françoise, Agosti, Donat, Baldrian, Petr, Balech, Bachir, Corre, Erwan, Davey, Robert P, Lantz, Henrik, Pesole, Graziano, Quast, Christian, Glöckner, Frank Oliver, Raes, Niels, Sandionigi, Anna, Santamaria, Monica, Addink, Wouter, Vohradsky, Jiri, Nunes-Jorge, Amandine, Willassen, Nils Peder, and Lanfear, Jerry
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Threats to global biodiversity are increasingly recognised by scientists and the public as a critical challenge. Molecular sequencing technologies offer means to catalogue, explore, and monitor the richness and biogeography of life on Earth. However, exploiting their full potential requires tools that connect biodiversity infrastructures and resources. As a research infrastructure developing services and technical solutions that help integrate and coordinate life science resources across Europe, ELIXIR is a key player. To identify opportunities, highlight priorities, and aid strategic thinking, here we survey approaches by which molecular technologies help inform understanding of biodiversity. We detail example use cases to highlight how DNA sequencing is: resolving taxonomic issues; Increasing knowledge of marine biodiversity; helping understand how agriculture and biodiversity are critically linked; and playing an essential role in ecological studies. Together with examples of national biodiversity programmes, the use cases show where progress is being made but also highlight common challenges and opportunities for future enhancement of underlying technologies and services that connect molecular and wider biodiversity domains. Based on emerging themes, we propose key recommendations to guide future funding for biodiversity research: biodiversity and bioinformatic infrastructures need to collaborate closely and strategically; taxonomic efforts need to be aligned and harmonised across domains; metadata needs to be standardised and common data management approaches widely adopted; current approaches need to be scaled up dramatically to address the anticipated explosion of molecular data; bioinformatics support for biodiversity research needs to be enabled and sustained; training for end users of biodiversity research infrastructures needs to be prioritised; and community initiatives need to be proactive and focused on enabling solutions. For sequencing data to delive
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- 2022
18. Neutral invertases in grapevine and comparative analysis with Arabidopsis, poplar and rice
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Nonis, Alberto, Ruperti, Benedetto, Pierasco, Alessandro, Canaguier, Aurelie, Adam-Blondon, Anne-Françoise, Di Gaspero, Gabriele, and Vizzotto, Giannina
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- 2008
19. Molecular characterization and expression analysis of the Rop GTPase family in Vitis vinifera
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Abbal, Philippe, Pradal, Martine, Sauvage, François-Xavier, Chatelet, Philippe, Paillard, Sophie, Canaguier, Aurélie, Adam-Blondon, Anne-Françoise, and Tesniere, Catherine
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- 2007
20. Preface
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Plomion, Christophe, primary and Adam-Blondon, Anne-Françoise, additional
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- 2015
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21. D4.4/D19 Strategy and priorities for delivering information services to end users
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ADAM-BLONDON, Anne-Françoise, TIXIER-BOICHARD, Michèle, BOZZANO, Michele, GORITSCHNIG, Sandra, SHARROCK, Suzanne, STURARO, Enrico, VAN HINTUM, Theo, WEISE, Stephan, WESTERGREN, Marjana, CHARVOLIN, Eleonore, DUCHEV, Zhivko, LALOE, Denis, MAGGIONI, Lorenzo, and HIEMSTRA, Sipke Joost
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Plant ,Forest ,Genetic Ressources ,Domestic Animal ,Data Management ,FAIR - Abstract
The deliverable D19/D4.4 of the GenRes Bridge project presents the overarching strategy on the documentation on Genetic Resource that has been developed to complement the overarching European Strategy on Genetic Resources (D2.4) and the new specific strategies of the three European networks of conservation of genetic resources, ECPGR, ERFP and EUFORGEN. A brief overview of the current global context concerning data on biodiversity, the achievements and current gaps of the three networks’s documentation activities is provided. This is completed by an overview of some important aspects of the legal frame of constraints and opportunities arising from the current ecosystem of initiatives supporting open science. The strategy proposes to leverage and adapt to the field of documentation on genetic resources the resources developed by the scientific community to support good data management practices compliant to the FAIR principles and ensure the development of a Findable, Accessible, Interoperable and Reusable wealth of data on genetic resources. The first set of proposed activities that should be developed at an overarching level by the networks where relevant are: development of standards, technology watch, training, capacity building and awareness raising on the importance of adopting and supporting good data management practices. Ultimately, they aim at increasing the quantity and the quality of data in the central repositories of the networks and at getting these repositories internationally recognized as trusted and FAIR compliant repositories. Another set of activities will allow the three networks to increase their participation in international initiatives developing the guidelines and resources supporting open linked data in relation with research and innovation in the areas of biodiversity, agriculture and forestry.
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- 2021
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22. ELIXIR-CONVERGE D5.2 Report on the first two DMP processes
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Portell, Laura, Capella-Gutierrez, Salvador, Alper, Pinar, d'Altri, Teresa, Hospital, Adam, Åberg, Espen, Faria, Daniel, Adam-Blondon, Anne-Françoise, Collin, Olivier, Willassen, Nils-Peder, Lieby, Paulette, Oulas, Anastasis, Pafilis, Evangelos, Jareborg, Niclas, Fatima, Nazeefa, Åkerström, Wolmar Nyberg, and Picardi, Ernesto
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Use Cases ,Data Management Plan ,CONVERGE ,DMP ,ELIXIR-CONVERGE ,Demonstrators ,ELIXIR - Abstract
The goal of ELIXIR Converge WP5 is to assess the capacity of ELIXIR and its national nodes to assist users’ projects in implementing Data Management Plans (DMPs) in their projects at a EU scale. To do that, six demonstrator use-cases were created and they are described in the previous deliverable (D5.1). This deliverable includes a description of the main resources that can be used to assess researchers in the process of creating DMPs for at least two use-cases including a gap analysis. The DMPs are related to the demonstrator use-case #1 (Plant sciences) and #3 (Marine metagenomics). Moreover, specific aspects for use-cases #4 (Human data) and #6 (Biomolecular simulation) are also added. The main activities described in this deliverable are related to the ELIXIR Research Data Management Kit (RDMkit) and the Data Stewardship Wizard (DSW) in connection with ELIXIR Converge WP3 activities. For all use-cases except use-case 5 (Toxicology data), a ‘Your domain’ page in the RDMkit has been assembled with the information necessary to consider when managing research data in their corresponding domains. Also, a ‘Tool assembly’ page in the RDMkit for the plant sciences, marine metagenomics and human data use-cases have been added. Finally, the DSW has been used to perform the initial description of the first DMPs including a gap analysis. Since ELIXIR Converge started, the work of WP5 has been centered in understanding the needs of the demonstrator use-cases to develop, if necessary, customized DMPs for each of them considering the domains they are part of. Also, once this characterization was done, several resources have been created to help users in the development of their DMPs. Indeed, these demonstrators are expected to serve as examples for researchers developing their own DMPs. The domain and tool assemblies pages added in the RDMkit are ready to use internally in ELIXIR after the beta-release in February, 2021. They provide a valuable resource for researchers and data stewards in the life sciences to help them in their data management processes. The Knowledge Models (KMs), the central component of the DSW, are under periodic revision to incorporate outcomes from ELIXIR Converge including specific aspects identified by the use-cases in order to complete their content and release an official version of them. The final objective is to provide refined DMP versions for the remaining 4 use-cases. This will allow us to cover a broad range of data-driven demonstrators, with its associated challenges, and assess how the general process scales up when applied to other communities served by ELIXIR. All these efforts will contribute to harden the work developed in other ELIXIR Converge WPs like the RDMkit and the DSW (WP3), the dedicated training materials and capacity building actions (WP2) as well as to provide reference information to the data management experts network (WP1) and external members to the project, e.g. Industry, in WP4.
- Published
- 2021
- Full Text
- View/download PDF
23. Recommendations for connecting molecular sequence and biodiversity research infrastructures through ELIXIR
- Author
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Waterhouse, Robert M., primary, Adam-Blondon, Anne-Françoise, additional, Agosti, Donat, additional, Baldrian, Petr, additional, Balech, Bachir, additional, Corre, Erwan, additional, Davey, Robert P., additional, Lantz, Henrik, additional, Pesole, Graziano, additional, Quast, Christian, additional, Glöckner, Frank Oliver, additional, Raes, Niels, additional, Sandionigi, Anna, additional, Santamaria, Monica, additional, Addink, Wouter, additional, Vohradsky, Jiri, additional, Nunes-Jorge, Amandine, additional, Willassen, Nils Peder, additional, and Lanfear, Jerry, additional
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- 2021
- Full Text
- View/download PDF
24. FAIR characterization data of genetic resources: making it real?
- Author
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Adam-Blondon, Anne-Françoise, Unité de Recherche Génomique Info (URGI), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Anne-Françoise Adam-Blondon, Mario Pezzotti, and European Project: CA17111,INTEGRAPE
- Subjects
[SDV]Life Sciences [q-bio] ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2021
25. ELIXIR-CONVERGE D5.1 Categorisation of the pilot projects
- Author
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Adam-Blondon, Anne-Françoise, Alper, Pinar, Capella-Gutierrez, Salvador, Faria, Daniel, Portell Silva, Laura, Hospital, Adam, and Willassen, Nils-Peder
- Subjects
RDMKit ,DMP Use Cases ,Data Management Plan ,CONVERGE ,DMP ,Demonstrators ,ELIXIR - Abstract
Task 5.1 aims to analyse the different demonstrators in light of the process necessary to implement their DMPs and to propose a categorisation based on users’ needs. This effort will provide input to WP1 with respect to needs in terms of experts and resources across ELIXIR Nodes (Task 1.3, Business plans). It is expected that some of them will be generic whereas others will be very specific to projects, which is an important factor for establishing a strategy towards the sustainability of such a service in all its diversity. D5.1 therefore describes the needs in terms of DMP of the demonstrator use-cases and proposes a project categorisation from the point of view of: - Area of expertise - The resources they use / toolkit - Training needs The first challenge was to develop a method to describe the needs of the users and their current practices in terms of data management as a prerequisite to the development of an adequate toolkit. The method adopted with the guidance of WP2 and WP3 relied on the description of users stories, and scenarios for different types of personas. In addition, a table was also developed to collect knowledge on the current practices and existing resources in terms of data management with guidance from WP1 and WP3. The six demonstrator use-cases are divided into two waves to facilitate having a broad diversity of data types, potential users and variable expertise and, at the same time, have first mature demonstrator use-cases that can start providing input to other WPs in the projects. The Plant and the Marine Metagenomics demonstrator use-cases were used as testers for the method developed as they are the two selected ones for the first wave. Federated access to human genomics data belongs to the second wave of demonstrator use-cases. However, considering its broad reach, it has been partially developed for this deliverable. User stories and scenarios with personas were developed by WP5 partners on the Plant, Marine metagenomics and Federated access to human genomics data: GDPR use-cases. The table on existing tools and resources was also filled in by WP5 partners and target interviews of researchers for some of the demonstrator use-cases. Additional input was sought from the ELIXIR communities for the demonstrator use-cases mentioned before. This method implemented to describe the demonstrator use-cases in detail has been efficient to isolate the specific context of each case, and to identify specific tools/resources in relation with the use-cases that can be used for data management. The main aspect used to classify a new use-case is the type of biological material linked to the data that links to many specific requirements, e.g. legal and scientific metadata. The second is the relation of the personas with the data, e.g. consumers/producers, and the type of data, including workflows, models, and the various types of experimental data. The landscape analysis of the resources already available in relation with the demonstrator use-cases and the different stages of a data management plan, showed that the guidelines developed by WP1 are very useful to clarify the scope of these stages before filling such a survey. The personas/users related to the use-cases are very diverse but always include the researchers in various positions, e.g. data consumer, data producer, data owner, PI writing a proposal, and the data curators. This will be further developed in collaboration with WP2. Finally, the work achieved to deliver D5.1 facilitated the development of pages dedicated to the “domains” in the RDMKit website (https://rdmkit.elixir-europe.org/) for demonstrator use-case 1, 3, 4 and 6. In these pages, specific challenges linked with the demonstrator use-cases are highlighted, and dedicated resources to solve them are listed. These tools have also been flagged in bio.tools with the domain name.
- Published
- 2021
- Full Text
- View/download PDF
26. ELIXIR-CONVERGE: Connect and align ELIXIR Nodes to deliver sustainable FAIR life-science data management services (871075)
- Author
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Adam-Blondon, Anne-Françoise, Alper, Pinar, Capella-Guttierez, Salvador, Faria, Daniel, Portell Silva, Laura, Hospital, Adam, Willassen, Nils-Peder, Unité de Recherche Génomique Info (URGI), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université du Luxembourg (UNI.LU), Barcelona Supercomputing Center - Centro Nacional de Supercomputacion (BSC - CNS), Instituto de Engenharia de Sistemas e Computadores (INESC), Institute for Research in Biomedicine [Barcelona, Spain] (IRB), University of Barcelona-Barcelona Institute of Science and Technology (BIST), The Arctic University of Norway (UiT), This project has received funding from the European Union’s Horizon 2020 Research and Innovation programme under grant agreement No 871075., INRAE, European Project: 871075,ELIXIR-CONVERGE, and The Arctic University of Norway [Tromsø, Norway] (UiT)
- Subjects
Use Cases ,Data management tools ,Data management plan ,Persona development ,[SDV]Life Sciences [q-bio] - Abstract
Task 5.1 aims to analyse the different demonstrators in light of the process necessary to implement their DMPs and to propose a categorization based on users’ needs. This effort will provide input to WP1 with respect to needs in terms of experts and resources across ELIXIR Nodes (Task 1.3, Business plans). It is expected that some of them will be generic whereas others will be very specific to projects, which is an important factor for establishing a strategy towards the sustainability of such a service in all its diversity.D5.1 therefore describes the needs in terms of DMP of the demonstrator use-cases and proposes a project categorization from the point of view of :- Area of expertise- The resources they use / toolkit- Training needsThe first challenge was to develop a method to describe the needs of the users and their current practices in terms of data management as a prerequisite to the development of an adequate toolkit. The method adopted with the guidance of WP2 and WP3 relied on the description of users stories, and scenarios for different types of personas. In addition, a table was also developed to collect knowledge on the current practices and existing resources in terms of data management with guidance from WP1 and WP3. The six demonstrator use-cases are divided into two waves to facilitate having a broad diversity of data types, potential users and variable expertise and, at the same time, have first mature demonstrator use-cases that can start providing input to other WPs in the projects. The Plant and the Marine Metagenomics demonstrator use-cases were used as testers for the method developed as they are the two selected ones for the first wave. Federated access to human genomics data belongs to the second wave of demonstrator use-cases. However, considering its broad reach, it has been partially developed for this deliverable. User stories and scenarios with personas were developed by WP5 partners on the Plant, Marine metagenomics and Federated access to human genomics data: GDPR use-cases. The table on existing tools and resources was also filled in by WP5 partners and target interviews of researchers for some of the demonstrator use-cases. Additional input was sought from the ELIXIR communities for the demonstrator use-cases mentioned before.This method implemented to describe the demonstrator use-cases in detail has beenefficient to isolate the specific context of each case, and to identify specific tools/resources in relation with the use-cases that can be used for data management.The main aspect used to classify a new use-case is the type of biological material linked to the data that links to many specific requirements, e.g. legal and scientific metadata. The second is the relation of the personas with the data, e.g. consumers/producers, and the type of data, including workflows, models, and the various types of experimental data. The landscape analysis of the resources already available in relation with the demonstrator use-cases and the different stages of a data management plan, showed that the guidelines developed by WP1 are very useful to clarify the scope of these stages before filling such a survey.The personas/users related to the use-cases are very diverse but always include the researchers in various positions, e.g. data consumer, data producer, data owner, PI writing a proposal, and the data curators. This will be further developed in collaboration with WP2. Finally, the work achieved to deliver D5.1 facilitated the development of pages dedicated to the “domains” in the RDMKit website (https://rdmkit.elixir-europe.org/) for demonstrator use-case 1, 3, 4 and 6. In these pages, specific challenges linked with the demonstrator use-cases are highlighted, and dedicated resources to solve them are listed. These tools have also been flagged in bio.tools with the domain name.
- Published
- 2021
27. ELIXIR-CONVERGE: Annex 1 to Deliverable D5.1 - User Stories_v1
- Author
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Adam-Blondon, Anne-Françoise, Alper, Pinar, Capella-Gutierrez, Salvador, Faria, Daniel, Portell Silva, Laura, Hospital, Adam, and Willassen, Nils-Peder
- Subjects
CONVERGE ,ELIXIR - Abstract
Annex 1 to ELIXIR-CONVERGE Deliverable D5.1 - Categorisation of the pilot projects
- Published
- 2021
- Full Text
- View/download PDF
28. Webinar on Plant Data Management for Phenotyping Experiments
- Author
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Pommier Cyril, Michotey Celia, and ADAM BLONDON Anne-Françoise
- Subjects
FAIR, data standard, Plant Phenotyping, MIAPPE, Crop Ontology, MCPD - Abstract
The Minimal Information About Plant Phenotyping Experiment, MIAPPE (www.miappe.org) has been designed by ELIXIR, EMPHASIS and Bioversity international to guide plant scientists in the management of experimental data and to facilitate integration with genotyping data.The webinar gives an overview of the current practices and methods for plant phenotyping data standardization. A recording of the webinar is available:https://youtu.be/Fq2j16jzdBA The webinar was organized in the frame of the AGENT and GenRes Bridge projects that received funding from the European Union’s Horizon 2020 research and innovation programme under respective grant agreements No 862613, and No 817580.
- Published
- 2021
- Full Text
- View/download PDF
29. Resistance to Plasmopara viticola in grapevine ‘Bianca’ is controlled by a major dominant gene causing localised necrosis at the infection site
- Author
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Bellin, Diana, Peressotti, Elisa, Merdinoglu, Didier, Wiedemann-Merdinoglu, Sabine, Adam-Blondon, Anne-Françoise, Cipriani, Guido, Morgante, Michele, Testolin, Raffaele, and Di Gaspero, Gabriele
- Published
- 2009
- Full Text
- View/download PDF
30. Developing infrastructures for FAIR data in plant biology
- Author
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Pommier, Cyril, Cornut, Guillaume, Alaux, Michael, Dzale Yeumo, Windpouire Esther, Flores, Raphaël, Letellier, Thomas, Michotey, Célia, Mohellibi, Nacer, Durand, Sophie, Kimmel, Erik, Quesneville, Hadi, Adam-Blondon, Anne-Françoise, Unité de Recherche Génomique Info (URGI), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité centrale de documentation information scientifique et technique de versailles UC DIST, Institut National de la Recherche Agronomique (INRA), IPK, European Project: 676559,H2020,H2020-INFRADEV-1-2015-1,ELIXIR-EXCELERATE(2015), ADAM-BLONDON, Anne-Françoise, and ELIXIR-EXCELERATE: Fast-track ELIXIR implementation and drive early user exploitation across the life-sciences. - ELIXIR-EXCELERATE - - H20202015-09-01 - 2019-08-31 - 676559 - VALID
- Subjects
[SDV] Life Sciences [q-bio] ,[SDV]Life Sciences [q-bio] ,Data Management Plan ,Plant - Abstract
International audience; INRA is involved in several EU infrastructures (e.g. ELIXIR, EMPHASIS) or global initiatives (e.g. Wheat Initiative, Research Data Alliance) contributing to the development of : (i) community recommendations for data standardization (e.g. Dzale-Yeumo et al 2017, https://doi.org/10.12688/f1000research.12234.2), (ii) data standards for phenotyping data (www.miappe.org), (iii) crop specific ontologies in the frame of the CropOntology (http://www.cropontology.org/) and (iv) standard web services (www.brapi.org). These global resources are used to capture the data produced in large scientific projects with a standard and structured vocabulary and to store them into INRA’s central repository for plant genomic, phenomic and genetic data, GnpIS (https://urgi.versailles.inra.fr/gnpis/) under the FAIR principles (https://www.force11.org/group/fairgroup/fairprinciples). In parallel, we have developed tools to support federation of databases. The first one is a light data discovery tool based on text indexing technologies, which allows to find data across several distinct databases based on a common high level generic data model (Spannagl et al 2016). The current federates 15 databases from 6 countries (https://urgi.versailles.inra.fr/wheatis/). Another tool allowing data search on phenotyping data and based on BrAPI web services is also about to be released in the frame of the H2020 ELIXIR-Excelerate project, n°676559. The long term resilience and success of such federations will highly depend on the capacity to animate and structure the community working on data for plant biology.
- Published
- 2019
31. A reference integrated map for cultivated grapevine (Vitis vinifera L.) from three crosses, based on 283 SSR and 501 SNP-based markers
- Author
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Vezzulli, Silvia, Troggio, Michela, Coppola, Giuseppina, Jermakow, Angelica, Cartwright, Dustin, Zharkikh, Andrey, Stefanini, Marco, Grando, M. Stella, Viola, Roberto, Adam-Blondon, Anne-Françoise, Thomas, Mark, This, Patrice, and Velasco, Riccardo
- Published
- 2008
- Full Text
- View/download PDF
32. Physical mapping in large genomes: accelerating anchoring of BAC contigs to genetic maps through in silico analysis
- Author
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Paux, Etienne, Legeai, Fabrice, Guilhot, Nicolas, Adam-Blondon, Anne-Françoise, Alaux, Michaël, Salse, Jérôme, Sourdille, Pierre, Leroy, Philippe, and Feuillet, Catherine
- Published
- 2008
- Full Text
- View/download PDF
33. Anchoring of a large set of markers onto a BAC library for the development of a draft physical map of the grapevine genome
- Author
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Lamoureux, Didier, Bernole, Anne, Le Clainche, Isabelle, Tual, Sarah, Thareau, Vincent, Paillard, Sophie, Legeai, Fabrice, Dossat, Carole, Wincker, Patrick, Oswald, Marilyn, Merdinoglu, Didier, Vignault, Céline, Delrot, Serge, Caboche, Michel, Chalhoub, Boulos, and Adam-Blondon, Anne-Françoise
- Published
- 2006
- Full Text
- View/download PDF
34. Development and characterization of a large set of microsatellite markers in grapevine (Vitis vinifera L.) suitable for multiplex PCR
- Author
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Merdinoglu, Didier, Butterlin, Giséle, Bevilacqua, Lucie, Chiquet, Vincent, Adam-Blondon, Anne-Françoise, and Decroocq, Stéphane
- Published
- 2005
- Full Text
- View/download PDF
35. Genetic dissection of a TIR-NB-LRR locus from the wild North American grapevine species Muscadinia rotundifolia identifies paralogous genes conferring resistance to major fungal and oomycete pathogens in cultivated grapevine
- Author
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Feechan, Angela, Anderson, Claire, Torregrosa, Laurent, Jermakow, Angelica, Mestre, Pere, Wiedemann-Merdinoglu, Sabine, Merdinoglu, Didier, Walker, Amanda R., Cadle-Davidson, Lance, Reisch, Bruce, Aubourg, Sebastien, Bentahar, Nadia, Shrestha, Bipna, Bouquet, Alain, Adam-Blondon, Anne-Françoise, Thomas, Mark R., and Dry, Ian B.
- Published
- 2013
- Full Text
- View/download PDF
36. A grapevine Shaker inward K+ channel activated by the calcineurin B-like calcium sensor 1–protein kinase CIPK23 network is expressed in grape berries under drought stress conditions
- Author
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Cuéllar, Teresa, Pascaud, François, Verdeil, Jean-Luc, Torregrosa, Laurent, Adam-Blondon, Anne-Françoise, Thibaud, Jean-Baptiste, Sentenac, Hervé, and Gaillard, Isabelle
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- 2010
- Full Text
- View/download PDF
37. A new version of the grapevine reference genome assembly (12X.v2) and of its annotation (VCost.v3)
- Author
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Institut National de la Recherche Agronomique (France), Università degli Studi di Udine, Institute of Applied Genomics (Italy), Flanders Institute for Biotechnology, Ghent University, European Cooperation in Science and Technology, Agence Nationale de la Recherche (France), Ministero delle Politiche Agricole Alimentari e Forestali, Adam-Blondon, Anne-Françoise [0000-0002-3412-9086], Canaguier, Aurélie, Grimplet, Jérôme, Di Gaspero, Gabriele, Scalabrin, Simone, Duchêne, Eric, Choisne, Nathalie, Mohellibi, Nacer, Guichard, Cécile, Rombauts, Stéphane, Le Clainche, Isabelle, Bérard, Aurélie, Chauveau, Aurélie, Bounon, Rémi, Rustenholz, Camille, Morgante, Michele, Le Paslier, Marie Christine, Brunel, Dominique, Adam-Blondon, Anne-Françoise, Institut National de la Recherche Agronomique (France), Università degli Studi di Udine, Institute of Applied Genomics (Italy), Flanders Institute for Biotechnology, Ghent University, European Cooperation in Science and Technology, Agence Nationale de la Recherche (France), Ministero delle Politiche Agricole Alimentari e Forestali, Adam-Blondon, Anne-Françoise [0000-0002-3412-9086], Canaguier, Aurélie, Grimplet, Jérôme, Di Gaspero, Gabriele, Scalabrin, Simone, Duchêne, Eric, Choisne, Nathalie, Mohellibi, Nacer, Guichard, Cécile, Rombauts, Stéphane, Le Clainche, Isabelle, Bérard, Aurélie, Chauveau, Aurélie, Bounon, Rémi, Rustenholz, Camille, Morgante, Michele, Le Paslier, Marie Christine, Brunel, Dominique, and Adam-Blondon, Anne-Françoise
- Abstract
The grapevine reference genome was published by Jaillon et al. [1]. The sequence for the first version of the genome, called the 8X version, was obtained using a whole genome shotgun strategy and the Sanger sequencing technology and was assembled from reads representing 8X coverage. Soon after, the assembly was improved through the addition of 4X of additional coverage, including more Bacterial Artificial Chromosome end sequences that greatly improved the scaffolding of the sequence contigs [2], [3]. The corresponding scaffolds and raw sequences were deposited in European Molecular Biology Laboratory (EMBL) archives (FN594950-FN597014, 2065 entries, release 102). A new chromosome assembly was also developed, based on an improved version of the maps used for the 8X genome version [2], [3], [4], [5] and was also archived at EMBL (FN597015-FN597047, 33 entries, release 102): it is referenced in the grapevine community as the 12X.v0 version of the grapevine reference genome. The chromosome sequence scaffolding of this version still necessitated improvements as around 9% of the sequence was not anchored to chromosomes (with the corresponding scaffolds stacked in the “Unknown” chromosome) and 3.5% of the sequence could be assigned to a chromosome but without certain placement and orientation within the chromosome (stacked in additional “random” chromosomes).
- Published
- 2017
38. The ELIXIR infrastructure for plant phenotyping-genotyping data management
- Author
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Adam-Blondon, Anne-Françoise, Unité de Recherche Génomique Info (URGI), Institut National de la Recherche Agronomique (INRA), ITQB, ELIXIR-PT, and European Project: 676559,H2020,H2020-INFRADEV-1-2015-1,ELIXIR-EXCELERATE(2015)
- Subjects
[SDV]Life Sciences [q-bio] ,Plant Biology ,Data managment ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2019
39. ELIXIR-EXCELERATE D7.3: Implementation of BRAPI (Plant Breeding API) at all participating nodes
- Author
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Miguel, Célia, Pommier, Cyril, Finkers, Richard, Coppens, Frederik, Bolser, Dan, Ruiz, Manuel, Adam-Blondon, Anne-Françoise, Gruden, Kristina, Ramšak, Živa, Papoutsoglou, Evangelia, Faria, Daniel, Costa, Bruno, and Chaves, Inês
- Subjects
FAIDARE ,BrAPI ,phenotype ,breeding ,plant ,EXCELERATE ,ELIXIR ,omics ,FAIR - Abstract
High-throughput “omics” technologies are widely used and increasingly important to support plant biology research and breeding of diverse plant species for production of food, feed, fibre and other biomaterials, and bio-energy. Significant advances in plant science can be obtained from the integration of available genomic and genotyping data with diverse types of phenotyping data, including field or greenhouse experimental data, molecular, -omics and image data. Although most -omics data, and especially phenomic data, are being generated in increasing scale, either from public or private research institutes, the dispersion of datasets and metadata among multiple repositories and their often poor description and annotation, make their use and exploitation still challenging or even unapproachable. To help unlock the full potential of a multi-omics approach to plant science, the overarching goal of this work package is to make plant data reusable and interoperable in accordance with the FAIR principles (i.e. Findable, Accessible, Interoperable and Re-usable). Hence, several standards have been built these past years for the annotation of data sets, and the ELIXIR plant community is co-authoring most of them. Their use has been demonstrated by exemplary application to data from diverse species published in public repositories (Deliverable 7.1). They are also the foundation of the ELIXIR Plant Data Search Service, FAIDARE, that gives access to distributed and standardized datasets. This service uses the Breeding API (BrAPI1), an API for accessing data relevant for plant breeding developed by the international plant community (Deliverable 7.2). It is based on a federation of plant phenotyping/genotyping data repositories, accessible through a single data discovery webportal2, that connects not only ELIXIR data repositories, but also any other Breeding API compatible database. This work represents a major step towards plant FAIR data and a significant tool for the international plant community focused on plant breeding, either of crops or forest trees. Furthermore, with this deliverable we reach the main goal of WP7, to provide a distributed infrastructure to allow plant genotype-phenotype analysis based on the widest available public datasets, and we give an important contribution to address goal one of the ELIXIR-EXCELERATE project: Deliver world-leading data services for academia and industry.
- Published
- 2019
- Full Text
- View/download PDF
40. Opportunities and needs within the consortium
- Author
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Adam-Blondon, Anne-Françoise, Pezzotti, Mario, Daniela, Holtgraewe, Kersey, Paul, Unité de Recherche Génomique Info (URGI), Institut National de la Recherche Agronomique (INRA), University of Verona (UNIVR), Universität Bielefeld = Bielefeld University, Royal Botanic Garden , Kew, Adam-Blondon A-F, Pezzotti M, European Project: CA17111,INTEGRAPE, Università degli studi di Verona = University of Verona (UNIVR), and Royal Botanic Gardens [Kew]
- Subjects
Grapes ,Bioinformatics ,[SDV]Life Sciences [q-bio] ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2019
41. Palaeogenomic insights into the origins of French grapevine diversity
- Author
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Danish Council for Independent Research, Agence Nationale de la Recherche (France), Ramos-Madrigal, Jazmín, Wiborg Runge, Anne Kathrine, Laurent, Bouby, Lacombe, Thierry, Samaniego Castruita, José Alfredo, Adam-Blondon, Anne-Françoise, Figueiral, Isabel, Hallavant, Charlotte, Martínez-Zapater, José M., Schaal, Caroline, Töpfer, Reinhard, Petersen, Bent, Sicheritz-Pontén, Thomas, This, Patrice, Bacilieri, Roberto, Gilbert, Thomas P., Wales, Nathan, Danish Council for Independent Research, Agence Nationale de la Recherche (France), Ramos-Madrigal, Jazmín, Wiborg Runge, Anne Kathrine, Laurent, Bouby, Lacombe, Thierry, Samaniego Castruita, José Alfredo, Adam-Blondon, Anne-Françoise, Figueiral, Isabel, Hallavant, Charlotte, Martínez-Zapater, José M., Schaal, Caroline, Töpfer, Reinhard, Petersen, Bent, Sicheritz-Pontén, Thomas, This, Patrice, Bacilieri, Roberto, Gilbert, Thomas P., and Wales, Nathan
- Abstract
The Eurasian grapevine (Vitis vinifera) has long been important for wine production as well as being a food source. Despite being clonally propagated, modern cultivars exhibit great morphological and genetic diversity, with thousands of varieties described in historic and contemporaneous records. Through historical accounts, some varieties can be traced to the Middle Ages, but the genetic relationships between ancient and modern vines remain unknown. We present target-enriched genome-wide sequencing data from 28 archaeological grape seeds dating to the Iron Age, Roman era and medieval period. When compared with domesticated and wild accessions, we found that the archaeological samples were closely related to western European cultivars used for winemaking today. We identified seeds with identical genetic signatures present at different Roman sites, as well as seeds sharing parent–offspring relationships with varieties grown today. Furthermore, we discovered that one seed dated to ~1100 CE was a genetic match to ‘Savagnin Blanc’, providing evidence for 900 years of uninterrupted vegetative propagation.
- Published
- 2019
42. Datasets annotated for at least 1 woody plant, cereal and solanaceous species; genotype, phenotype and sample metadata submitted to appropriate public archives
- Author
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Adam-Blondon, Anne-Françoise, Chaves, Inês, Coppens, Friederik, Costa, Bruno, Finkers, Richard, Horro, Carlos, Kersey, Paul, Mihotey, Celia, Miguel, Celia, Papoutsoglu, Evangelia, Pommier, Cyril, and Ramsak, Ziva
- Abstract
Plant omics data is often not published, or dispersed among multiple repositories and,owing to poor annotation of submissions with descriptive metadata, effectively not FAIR(i.e. Findable, Accessible, Interoperable and Re-usable). In this work package, our goal isto make plant -omics data FAIR, and the first part of this work has involved thedevelopment of standards for the annotation of data sets, and their exemplary applicationto diverse data from diverse species. Finally, the annotated data has been made availablein the public repositories. In developing these standards, we have built from previous work in the field, most notablythe development of the Minimal Information about a Plant Phenotyping experiment(MIAPPE) standard (http://www.miappe.org). We have taken MIAPPE as our startingpoint, and extended and revised it according to the characteristics of our exemplar data. Because a proposed standard becomes a real one through its adoption, we have activelyparticipated in the wider community developing MIAPPE, with the goal of incorporatingour developments within the official MIAPPE specification. A particularly important issue is the identification of material used in an experiment.Materials used within and between experiments may be related to each other (by time,space, condition or genealogy), and multiple assays may be taken from the samematerial; moreover, what is often of interest is to connect experimental data to thephysical material assayed (or at least, related physical material, such as a stock held in agermplasm repository). We have taken special care in aligning the MIAPPE standardswith the FAO Multi Crop Passport Descriptor Data standard used by the gene banks andused the BioSamples database (http://www.ebi.ac.uk/biosamples) as an integrative layerto allow us to capture the relationships between samples and the measurements thathave been made upon them.
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- 2018
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43. Extended diversity analysis of cultivated grapevine Vitis vinifera with 10K genome-wide SNPs
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Laucou, Valérie, Launay, Amandine, Bacilieri, Roberto, Lacombe, Thierry, Adam-Blondon, Anne-Françoise, Bérard, Aurélie, Chauveau, Aurélie, de Andrés, Maria Teresa, Hausmann, Ludger, Ibáñez, Javier, Le Paslier, Marie-Christine, Maghradze, David, Martinez-Zapater, José Miguel, Maul, Erika, Ponnaiah, Maharajah, Töpfer, Reinhard, Péros, Jean-Pierre, Boursiquot, Jean-Michel, Amélioration génétique et adaptation des plantes méditerranéennes et tropicales (UMR AGAP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Unité de Recherche Génomique Info (URGI), Institut National de la Recherche Agronomique (INRA), Etude du Polymorphisme des Génomes Végétaux (EPGV), Instituto Madrileño de Investigación y Desarrollo Rural, Agrario y Alimentario (IMIDRA), Institute for grapevine breeding Geilweilerhof (IRZ), Universidad de La Rioja (UR), National Wine Agency of Georgia, Research project of Transnational Plant Alliance for Novel Technologies toward implementing the Knowledge Based Bio-Economy (PLANT - KBBE) in Europe (France, Germany and Spain), European Commission, Hausmann, Ludger, Ibáñez Marcos, Javier, Martínez-Zapater, José M., Hausmann, Ludger [0000-0002-4046-9626], Ibáñez Marcos, Javier [0000-0002-6286-5638], and Martínez-Zapater, José M. [0000-0001-7217-4454]
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Heredity ,Grapes ,Animal Types ,[SDV]Life Sciences [q-bio] ,lcsh:Medicine ,Wine ,Variant Genotypes ,Polymorphism, Single Nucleotide ,Linkage Disequilibrium ,Fruits ,Beverages ,Molecular Genetics ,vitis vinifera ,Genome-Wide Association Studies ,Genetics ,Medicine and Health Sciences ,Animals ,[SDV.BV]Life Sciences [q-bio]/Vegetal Biology ,Domestic Animals ,Inbreeding ,Vitis ,lcsh:Science ,Molecular Biology ,Flowering Plants ,Nutrition ,Alcoholic Beverages ,génome ,lcsh:R ,Organisms ,matrice ,Biology and Life Sciences ,Computational Biology ,Eukaryota ,Genetic Variation ,Human Genetics ,Genomics ,Plants ,Genome Analysis ,Diet ,Genetic Mapping ,génotypage ,Grapevine ,lcsh:Q ,vigne ,Zoology ,Genome, Plant ,Research Article ,Genome-Wide Association Study - Abstract
Grapevine is a very important crop species that is mainly cultivated worldwide for fruits, wine and juice. Identification of the genetic bases of performance traits through association mapping studies requires a precise knowledge of the available diversity and how this diversity is structured and varies across the whole genome. An 18k SNP genotyping array was evaluated on a panel of Vitis vinifera cultivars and we obtained a data set with no missing values for a total of 10207 SNPs and 783 different genotypes. The average inter-SNP spacing was ~47 kbp, the mean minor allele frequency (MAF) was 0.23 and the genetic diversity in the sample was high (He = 0.32). Fourteen SNPs, chosen from those with the highest MAF values, were sufficient to identify each genotype in the sample. Parentage analysis revealed 118 full parentages and 490 parent-offspring duos, thus confirming the close pedigree relationships within the cultivated grapevine. Structure analyses also confirmed the main divisions due to an eastern-western gradient and human usage (table vs. wine). Using a multivariate approach, we refined the structure and identified a total of eight clusters. Both the genetic diversity (He, 0.26–0.32) and linkage disequilibrium (LD, 28.8–58.2 kbp) varied between clusters. Despite the short span LD, we also identified some non-recombining haplotype blocks that may complicate association mapping. Finally, we performed a genomewide association study that confirmed previous works and also identified new regions for important performance traits such as acidity. Taken together, all the results contribute to a better knowledge of the genetics of the cultivated grapevine, The GrapeReSeq project (Large scale resequencing in the Vitis genus for identification of resistance genes, SNP discovery and high throughput genotyping) was funded by Research project of Transnational Plant Alliance for Novel Technologies toward implementing the Knowledge Based Bio-Economy (PLANT - KBBE2008) in Europe (France, Germany and Spain)
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- 2018
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44. Data standards for plant phenotyping: MIAPPE and its implementations
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Pommier, Cyril, Cornut, Guillaume, Letellier, Thomas, Michotey, Célia, Neveu, Pascal, Ruiz, Manuel, Larmande, Pierre, Kersey, Paul J., Cwiek Kupczynska, Hanna, Krajewski, Paweł, Coppens, Frederik, Finkers, Richard, Laporte, Marie-Angélique, Faria, Daniel, Miguel, Célia M., Chavez, Inês, Adam Blondon, Anne-Françoise, Costa, Bruno, Unité de Recherche Génomique Info (URGI), Institut National de la Recherche Agronomique (INRA), Université Paris Saclay (COmUE), Mathématiques, Informatique et STatistique pour l'Environnement et l'Agronomie (MISTEA), Institut National de la Recherche Agronomique (INRA)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Amélioration génétique et adaptation des plantes méditerranéennes et tropicales (UMR AGAP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut de Recherche pour le Développement (IRD), European Molecular Biology Laboratory European Bioinformatics Institute, Institute of Plant Genetics, Polska Akademia Nauk = Polish Academy of Sciences (PAN), Polish Academy of Sciences (PAN), Department of plant systems biology, Flanders Institute for Biotechnology, Plant Breeding, Wageningen University and Research [Wageningen] (WUR), Bioversity International [Montpellier], Bioversity International [Rome], Consultative Group on International Agricultural Research [CGIAR] (CGIAR)-Consultative Group on International Agricultural Research [CGIAR] (CGIAR), Instituto Gulbenkian de Ciência, Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Phenome Emphasis France, and European Project: 211601,EC:FP7:INFRA,FP7-INFRASTRUCTURES-2007-1,ELIXIR(2007)
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[SDV]Life Sciences [q-bio] ,[SDV.BV]Life Sciences [q-bio]/Vegetal Biology ,[INFO]Computer Science [cs] ,[MATH]Mathematics [math] - Abstract
International audience; Plant Phenotyping data management following the FAIR (Findable, Accessible, Interoperable, Resusable) is highly challenging because of its heterogenity. Thus, simply integrating and consolidating data within a single dataset like a phenotyping network is already a complicated task which is even more complex when trying to link different datasets together. To adress this problem, the Minimal Information About Plant Phenotyping Experiment standard construction has been initiated four years ago, with the help of experts from European infrastructures and institutes like Elixir, Emphasis, INRA, WUR, iBet, IPK, EBI and IPG PAS. It adresses the need of data publication and reuse through a checklist that formalize and document the minimal metadata necessary to ensure long term FAIRness of field or greenhouse datasets, including high througputs phenotyping ones. This list has been implemented in several databases like GnpIS or eDale, in a file format, ISA Tab, in a web service, the Breeding API and an RDF implementation is under construction. We will review those implementations, show its current adoption state and detail the plans for the future evolutions of the standard.
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- 2018
45. Data standards for plant phenotyping: MIAPPE and its implementations [W785]
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Pommier, Cyril, Cornut, Guillaume, Letellier, Thomas, Michotey, Célia, Neveu, Pascal, Manuel Ruiz, Larmande, Pierre, Kersey, Paul J., Cwiek, Hanna, Krajewski, Pawel, Coppens, Frederik, Finkers, Richard, Laporte, Marie-Angélique, Faria, Daniel, Miguel, Célia M., Chavez, Ines, Adam-Blondon, Anne-Françoise, and Costa, Bruno
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F30 - Génétique et amélioration des plantes - Abstract
Plant Phenotyping data management following the FAIR (Findable, Accessible, Interoperable, Resusable) is highly challenging because of its heterogenity. Thus, simply integrating and consolidating data within a single dataset like a phenotyping network is already a complicated task which is even more complex when trying to link different datasets together. To adress this problem, the Minimal Information About Plant Phenotyping Experiment standard construction has been initiated four years ago, with the help of experts from European infrastructures and institutes like Elixir, Emphasis, INRA, WUR, iBet, IPK, EBI and IPG PAS. It adresses the need of data publication and reuse through a checklist that formalize and document the minimal metadata necessary to ensure long term FAIRness of field or greenhouse datasets, including high througputs phenotyping ones. This list has been implemented in several databases like GnpIS or eDale, in a file format, ISA Tab, in a web service, the Breeding API and an RDF implementation is under construction. We will review those implementations, show its current adoption state and detail the plans for the future evolutions of the standard.
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- 2018
46. Molecular, genetic and transcriptional evidence for a role of VvAGL11 in stenospermocarpic seedlessness in grapevine
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Boursiquot Jean-Michel, Le Cunff Loïc, Ramos Rodrigo, de los Ángeles Miccono María, Houel Cléa, Casanueva Ximena, Guerrero Marcos, Soto Braulio, Mejía Nilo, Hinrichsen Patricio, and Adam-Blondon Anne-Françoise
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Botany ,QK1-989 - Abstract
Abstract Background Stenospermocarpy is a mechanism through which certain genotypes of Vitis vinifera L. such as Sultanina produce berries with seeds reduced in size. Stenospermocarpy has not yet been characterized at the molecular level. Results Genetic and physical maps were integrated with the public genomic sequence of Vitis vinifera L. to improve QTL analysis for seedlessness and berry size in experimental progeny derived from a cross of two seedless genotypes. Major QTLs co-positioning for both traits on chromosome 18 defined a 92-kb confidence interval. Functional information from model species including Vitis suggested that VvAGL11, included in this confidence interval, might be the main positional candidate gene responsible for seed and berry development. Characterization of VvAGL11 at the sequence level in the experimental progeny identified several SNPs and INDELs in both regulatory and coding regions. In association analyses performed over three seasons, these SNPs and INDELs explained up to 78% and 44% of the phenotypic variation in seed and berry weight, respectively. Moreover, genetic experiments indicated that the regulatory region has a larger effect on the phenotype than the coding region. Transcriptional analysis lent additional support to the putative role of VvAGL11's regulatory region, as its expression is abolished in seedless genotypes at key stages of seed development. These results transform VvAGL11 into a functional candidate gene for further analyses based on genetic transformation. For breeding purposes, intragenic markers were tested individually for marker assisted selection, and the best markers were those closest to the transcription start site. Conclusion We propose that VvAGL11 is the major functional candidate gene for seedlessness, and we provide experimental evidence suggesting that the seedless phenotype might be caused by variations in its promoter region. Current knowledge of the function of its orthologous genes, its expression profile in Vitis varieties and the strong association between its sequence variation and the degree of seedlessness together indicate that the D-lineage MADS-box gene VvAGL11 corresponds to the Seed Development Inhibitor locus described earlier as a major locus for seedlessness. These results provide new hypotheses for further investigations of the molecular mechanisms involved in seed and berry development.
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- 2011
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47. Patterns of sequence polymorphism in the fleshless berry locus in cultivated and wild Vitis vinifera accessions
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Coriton Olivier, Vernerey Marie-Stéphanie, Le Paslier Marie-Christine, N'Diaye Amidou, Lacombe Thierry, Canaguier Aurélie, Dereeper Alexis, Bacilieri Roberto, Péros Jean-Pierre, Guichard Cécile, Chaïb Jamila, Bounon Rémi, Houel Cléa, Brunel Dominique, This Patrice, Torregrosa Laurent, and Adam-Blondon Anne-Françoise
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Botany ,QK1-989 - Abstract
Abstract Background Unlike in tomato, little is known about the genetic and molecular control of fleshy fruit development of perennial fruit trees like grapevine (Vitis vinifera L.). Here we present the study of the sequence polymorphism in a 1 Mb grapevine genome region at the top of chromosome 18 carrying the fleshless berry mutation (flb) in order, first to identify SNP markers closely linked to the gene and second to search for possible signatures of domestication. Results In total, 62 regions (17 SSR, 3 SNP, 1 CAPS and 41 re-sequenced gene fragments) were scanned for polymorphism along a 3.4 Mb interval (85,127-3,506,060 bp) at the top of the chromosome 18, in both V. vinifera cv. Chardonnay and a genotype carrying the flb mutation, V. vinifera cv. Ugni Blanc mutant. A nearly complete homozygosity in Ugni Blanc (wild and mutant forms) and an expected high level of heterozygosity in Chardonnay were revealed. Experiments using qPCR and BAC FISH confirmed the observed homozygosity. Under the assumption that flb could be one of the genes involved into the domestication syndrome of grapevine, we sequenced 69 gene fragments, spread over the flb region, representing 48,874 bp in a highly diverse set of cultivated and wild V. vinifera genotypes, to identify possible signatures of domestication in the cultivated V. vinifera compartment. We identified eight gene fragments presenting a significant deviation from neutrality of the Tajima's D parameter in the cultivated pool. One of these also showed higher nucleotide diversity in the wild compartments than in the cultivated compartments. In addition, SNPs significantly associated to berry weight variation were identified in the flb region. Conclusions We observed the occurrence of a large homozygous region in a non-repetitive region of the grapevine otherwise highly-heterozygous genome and propose a hypothesis for its formation. We demonstrated the feasibility to apply BAC FISH on the very small grapevine chromosomes and provided a specific probe for the identification of chromosome 18 on a cytogenetic map. We evidenced genes showing putative signatures of selection and SNPs significantly associated with berry weight variation in the flb region. In addition, we provided to the community 554 SNPs at the top of chromosome 18 for the development of a genotyping chip for future fine mapping of the flb gene in a F2 population when available.
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- 2010
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48. Construction of nested genetic core collections to optimize the exploitation of natural diversity in Vitis vinifera L. subsp. sativa
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Boursiquot Jean-Michel, Adam-Blondon Anne-Françoise, Lacombe Thierry, Vezzulli Silvia, Laucou Valérie, Fournier-Level Alexandre, Le Cunff Loïc, and This Patrice
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Botany ,QK1-989 - Abstract
Abstract Background The first high quality draft of the grape genome sequence has just been published. This is a critical step in accessing all the genes of this species and increases the chances of exploiting the natural genetic diversity through association genetics. However, our basic knowledge of the extent of allelic variation within the species is still not sufficient. Towards this goal, we constructed nested genetic core collections (G-cores) to capture the simple sequence repeat (SSR) diversity of the grape cultivated compartment (Vitis vinifera L. subsp. sativa) from the world's largest germplasm collection (Domaine de Vassal, INRA Hérault, France), containing 2262 unique genotypes. Results Sub-samples of 12, 24, 48 and 92 varieties of V. vinifera L. were selected based on their genotypes for 20 SSR markers using the M-strategy. They represent respectively 58%, 73%, 83% and 100% of total SSR diversity. The capture of allelic diversity was analyzed by sequencing three genes scattered throughout the genome on 233 individuals: 41 single nucleotide polymorphisms (SNPs) were identified using the G-92 core (one SNP for every 49 nucleotides) while only 25 were observed using a larger sample of 141 individuals selected on the basis of 50 morphological traits, thus demonstrating the reliability of the approach. Conclusion The G-12 and G-24 core-collections displayed respectively 78% and 88% of the SNPs respectively, and are therefore of great interest for SNP discovery studies. Furthermore, the nested genetic core collections satisfactorily reflected the geographic and the genetic diversity of grape, which are also of great interest for the study of gene evolution in this species.
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- 2008
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49. Shifting the limits in wheat research and breeding using a fully annotated reference genome
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Appels, Rudi, Eversole, Kellye, Stein, Nils, Feuillet, Catherine, Keller, Beat, Rogers, Jane, Pozniak, Curtis J., Choulet, Frédéric, Distelfeld, Assaf, Poland, Jesse, Ronen, Gil, Sharpe, Andrew G., Barad, Omer, Baruch, Kobi, Keeble-gagnère, Gabriel, Mascher, Martin, Ben-zvi, Gil, Josselin, Ambre-aurore, Himmelbach, Axel, Balfourier, François, Gutierrez-gonzalez, Juan, Hayden, Matthew, Koh, Chushin, Muehlbauer, Gary, Pasam, Raj K., Paux, Etienne, Rigault, Philippe, Tibbits, Josquin, Tiwari, Vijay, Spannagl, Manuel, Lang, Daniel, Gundlach, Heidrun, Haberer, Georg, Mayer, Klaus F. X., Ormanbekova, Danara, Prade, Verena, Šimková, Hana, Wicker, Thomas, Swarbreck, David, Rimbert, Hélène, Felder, Marius, Guilhot, Nicolas, Kaithakottil, Gemy, Keilwagen, Jens, Leroy, Philippe, Lux, Thomas, Twardziok, Sven, Venturini, Luca, Juhász, Angéla, Abrouk, Michael, Fischer, Iris, Uauy, Cristobal, Borrill, Philippa, Ramirez-gonzalez, Ricardo H., Arnaud, Dominique, Chalabi, Smahane, Chalhoub, Boulos, Cory, Aron, Datla, Raju, Davey, Mark W., Jacobs, John, Robinson, Stephen J., Steuernagel, Burkhard, Van Ex, Fred, Wulff, Brande B. H., Benhamed, Moussa, Bendahmane, Abdelhafid, Concia, Lorenzo, Latrasse, David, Bartoš, Jan, Bellec, Arnaud, Berges, Hélène, Doležel, Jaroslav, Frenkel, Zeev, Gill, Bikram, Korol, Abraham, Letellier, Thomas, Olsen, Odd-arne, Singh, Kuldeep, Valárik, Miroslav, Van Der Vossen, Edwin, Vautrin, Sonia, Weining, Song, Fahima, Tzion, Glikson, Vladimir, Raats, Dina, Číhalíková, Jarmila, Toegelová, Helena, Vrána, Jan, Sourdille, Pierre, Darrier, Benoit, Barabaschi, Delfina, Cattivelli, Luigi, Hernandez, Pilar, Galvez, Sergio, Budak, Hikmet, Jones, Jonathan D. G., Witek, Kamil, Yu, Guotai, Small, Ian, Melonek, Joanna, Zhou, Ruonan, Belova, Tatiana, Kanyuka, Kostya, King, Robert, Nilsen, Kirby, Walkowiak, Sean, Cuthbert, Richard, Knox, Ron, Wiebe, Krysta, Xiang, Daoquan, Rohde, Antje, Golds, Timothy, Čížková, Jana, Akpinar, Bala Ani, Biyiklioglu, Sezgi, Gao, Liangliang, N’daiye, Amidou, Kubaláková, Marie, Šafář, Jan, Alfama, Françoise, Adam-blondon, Anne-françoise, Flores, Raphael, Guerche, Claire, Loaec, Mikaël, Quesneville, Hadi, Condie, Janet, Ens, Jennifer, Maclachlan, Ron, Tan, Yifang, Alberti, Adriana, Aury, Jean-marc, Barbe, Valérie, Couloux, Arnaud, Cruaud, Corinne, Labadie, Karine, Mangenot, Sophie, Wincker, Patrick, Kaur, Gaganpreet, Luo, Mingcheng, Sehgal, Sunish, Chhuneja, Parveen, Gupta, Om Prakash, Jindal, Suruchi, Kaur, Parampreet, Malik, Palvi, Sharma, Priti, Yadav, Bharat, Singh, Nagendra K., Khurana, Jitendra P., Chaudhary, Chanderkant, Khurana, Paramjit, Kumar, Vinod, Mahato, Ajay, Mathur, Saloni, Sevanthi, Amitha, Sharma, Naveen, Tomar, Ram Sewak, Holušová, Kateřina, Plíhal, Ondřej, Clark, Matthew D., Heavens, Darren, Kettleborough, George, Wright, Jon, Balcárková, Barbora, Hu, Yuqin, Salina, Elena, Ravin, Nikolai, Skryabin, Konstantin, Beletsky, Alexey, Kadnikov, Vitaly, Mardanov, Andrey, Nesterov, Michail, Rakitin, Andrey, Sergeeva, Ekaterina, Handa, Hirokazu, Kanamori, Hiroyuki, Katagiri, Satoshi, Kobayashi, Fuminori, Nasuda, Shuhei, Tanaka, Tsuyoshi, Wu, Jianzhong, Cattonaro, Federica, Jiumeng, Min, Kugler, Karl, Pfeifer, Matthias, Sandve, Simen, Xun, Xu, Zhan, Bujie, Batley, Jacqueline, Bayer, Philipp E., Edwards, David, Hayashi, Satomi, Tulpová, Zuzana, Visendi, Paul, Cui, Licao, Du, Xianghong, Feng, Kewei, Nie, Xiaojun, Tong, Wei, Wang, Le, Appels, Rudi, Eversole, Kellye, Stein, Nils, Feuillet, Catherine, Keller, Beat, Rogers, Jane, Pozniak, Curtis J., Choulet, Frédéric, Distelfeld, Assaf, Poland, Jesse, Ronen, Gil, Sharpe, Andrew G., Barad, Omer, Baruch, Kobi, Keeble-gagnère, Gabriel, Mascher, Martin, Ben-zvi, Gil, Josselin, Ambre-aurore, Himmelbach, Axel, Balfourier, François, Gutierrez-gonzalez, Juan, Hayden, Matthew, Koh, Chushin, Muehlbauer, Gary, Pasam, Raj K., Paux, Etienne, Rigault, Philippe, Tibbits, Josquin, Tiwari, Vijay, Spannagl, Manuel, Lang, Daniel, Gundlach, Heidrun, Haberer, Georg, Mayer, Klaus F. X., Ormanbekova, Danara, Prade, Verena, Šimková, Hana, Wicker, Thomas, Swarbreck, David, Rimbert, Hélène, Felder, Marius, Guilhot, Nicolas, Kaithakottil, Gemy, Keilwagen, Jens, Leroy, Philippe, Lux, Thomas, Twardziok, Sven, Venturini, Luca, Juhász, Angéla, Abrouk, Michael, Fischer, Iris, Uauy, Cristobal, Borrill, Philippa, Ramirez-gonzalez, Ricardo H., Arnaud, Dominique, Chalabi, Smahane, Chalhoub, Boulos, Cory, Aron, Datla, Raju, Davey, Mark W., Jacobs, John, Robinson, Stephen J., Steuernagel, Burkhard, Van Ex, Fred, Wulff, Brande B. H., Benhamed, Moussa, Bendahmane, Abdelhafid, Concia, Lorenzo, Latrasse, David, Bartoš, Jan, Bellec, Arnaud, Berges, Hélène, Doležel, Jaroslav, Frenkel, Zeev, Gill, Bikram, Korol, Abraham, Letellier, Thomas, Olsen, Odd-arne, Singh, Kuldeep, Valárik, Miroslav, Van Der Vossen, Edwin, Vautrin, Sonia, Weining, Song, Fahima, Tzion, Glikson, Vladimir, Raats, Dina, Číhalíková, Jarmila, Toegelová, Helena, Vrána, Jan, Sourdille, Pierre, Darrier, Benoit, Barabaschi, Delfina, Cattivelli, Luigi, Hernandez, Pilar, Galvez, Sergio, Budak, Hikmet, Jones, Jonathan D. G., Witek, Kamil, Yu, Guotai, Small, Ian, Melonek, Joanna, Zhou, Ruonan, Belova, Tatiana, Kanyuka, Kostya, King, Robert, Nilsen, Kirby, Walkowiak, Sean, Cuthbert, Richard, Knox, Ron, Wiebe, Krysta, Xiang, Daoquan, Rohde, Antje, Golds, Timothy, Čížková, Jana, Akpinar, Bala Ani, Biyiklioglu, Sezgi, Gao, Liangliang, N’daiye, Amidou, Kubaláková, Marie, Šafář, Jan, Alfama, Françoise, Adam-blondon, Anne-françoise, Flores, Raphael, Guerche, Claire, Loaec, Mikaël, Quesneville, Hadi, Condie, Janet, Ens, Jennifer, Maclachlan, Ron, Tan, Yifang, Alberti, Adriana, Aury, Jean-marc, Barbe, Valérie, Couloux, Arnaud, Cruaud, Corinne, Labadie, Karine, Mangenot, Sophie, Wincker, Patrick, Kaur, Gaganpreet, Luo, Mingcheng, Sehgal, Sunish, Chhuneja, Parveen, Gupta, Om Prakash, Jindal, Suruchi, Kaur, Parampreet, Malik, Palvi, Sharma, Priti, Yadav, Bharat, Singh, Nagendra K., Khurana, Jitendra P., Chaudhary, Chanderkant, Khurana, Paramjit, Kumar, Vinod, Mahato, Ajay, Mathur, Saloni, Sevanthi, Amitha, Sharma, Naveen, Tomar, Ram Sewak, Holušová, Kateřina, Plíhal, Ondřej, Clark, Matthew D., Heavens, Darren, Kettleborough, George, Wright, Jon, Balcárková, Barbora, Hu, Yuqin, Salina, Elena, Ravin, Nikolai, Skryabin, Konstantin, Beletsky, Alexey, Kadnikov, Vitaly, Mardanov, Andrey, Nesterov, Michail, Rakitin, Andrey, Sergeeva, Ekaterina, Handa, Hirokazu, Kanamori, Hiroyuki, Katagiri, Satoshi, Kobayashi, Fuminori, Nasuda, Shuhei, Tanaka, Tsuyoshi, Wu, Jianzhong, Cattonaro, Federica, Jiumeng, Min, Kugler, Karl, Pfeifer, Matthias, Sandve, Simen, Xun, Xu, Zhan, Bujie, Batley, Jacqueline, Bayer, Philipp E., Edwards, David, Hayashi, Satomi, Tulpová, Zuzana, Visendi, Paul, Cui, Licao, Du, Xianghong, Feng, Kewei, Nie, Xiaojun, Tong, Wei, and Wang, Le
- Abstract
Wheat is one of the major sources of food for much of the world. However, because bread wheat's genome is a large hybrid mix of three separate subgenomes, it has been difficult to produce a high-quality reference sequence. Using recent advances in sequencing, the International Wheat Genome Sequencing Consortium presents an annotated reference genome with a detailed analysis of gene content among subgenomes and the structural organization for all the chromosomes. Examples of quantitative trait mapping and CRISPR-based genome modification show the potential for using this genome in agricultural research and breeding. Ramírez-González et al. exploited the fruits of this endeavor to identify tissue-specific biased gene expression and coexpression networks during development and exposure to stress. These resources will accelerate our understanding of the genetic basis of bread wheat.
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- 2018
50. Extended diversity analysis of cultivated grapevine Vitis vinifera with 10K genome-wide SNPs
- Author
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European Commission, Hausmann, Ludger [0000-0002-4046-9626], Ibáñez Marcos, Javier [0000-0002-6286-5638], Martínez-Zapater, José M. [0000-0001-7217-4454], Laucou, Valérie, Launay, ,Amandine, Bacilieri, Roberto, Lacombe, Thierry, Adam-Blondon, Anne-Françoise, Bérard, Aurélie, Chauveau, Aurélie, Andrés, M. Teresa de, Hausmann, Ludger, Ibáñez Marcos, Javier, Le Paslier, Marie Christine, Maghradze, David, Martínez-Zapater, José M., Maul, Erika, Ponnaiah, Maharajah, Töpfer, Reinhard, Péros, Jean Pièrre, Boursiquot, J. M., European Commission, Hausmann, Ludger [0000-0002-4046-9626], Ibáñez Marcos, Javier [0000-0002-6286-5638], Martínez-Zapater, José M. [0000-0001-7217-4454], Laucou, Valérie, Launay, ,Amandine, Bacilieri, Roberto, Lacombe, Thierry, Adam-Blondon, Anne-Françoise, Bérard, Aurélie, Chauveau, Aurélie, Andrés, M. Teresa de, Hausmann, Ludger, Ibáñez Marcos, Javier, Le Paslier, Marie Christine, Maghradze, David, Martínez-Zapater, José M., Maul, Erika, Ponnaiah, Maharajah, Töpfer, Reinhard, Péros, Jean Pièrre, and Boursiquot, J. M.
- Abstract
Grapevine is a very important crop species that is mainly cultivated worldwide for fruits, wine and juice. Identification of the genetic bases of performance traits through association mapping studies requires a precise knowledge of the available diversity and how this diversity is structured and varies across the whole genome. An 18k SNP genotyping array was evaluated on a panel of Vitis vinifera cultivars and we obtained a data set with no missing values for a total of 10207 SNPs and 783 different genotypes. The average inter-SNP spacing was ~47 kbp, the mean minor allele frequency (MAF) was 0.23 and the genetic diversity in the sample was high (He = 0.32). Fourteen SNPs, chosen from those with the highest MAF values, were sufficient to identify each genotype in the sample. Parentage analysis revealed 118 full parentages and 490 parent-offspring duos, thus confirming the close pedigree relationships within the cultivated grapevine. Structure analyses also confirmed the main divisions due to an eastern-western gradient and human usage (table vs. wine). Using a multivariate approach, we refined the structure and identified a total of eight clusters. Both the genetic diversity (He, 0.26–0.32) and linkage disequilibrium (LD, 28.8–58.2 kbp) varied between clusters. Despite the short span LD, we also identified some non-recombining haplotype blocks that may complicate association mapping. Finally, we performed a genomewide association study that confirmed previous works and also identified new regions for important performance traits such as acidity. Taken together, all the results contribute to a better knowledge of the genetics of the cultivated grapevine
- Published
- 2018
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