11 results on '"Accorsi L"'
Search Results
2. Does malnutrition affect survival in cirrhosis?
- Author
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Merli, M, Riggio, O, Dally, L, Capocaccia, L, Lionetti, R, Deluca, M, Guardascione, Ma, Surrenti, M, Marra, F, Gentilini, P, Nardone, G, Budillon, G, Loguercio, C, Blanco, Cd, Coltorti, M, Guglielmi, W, Francavilla, A, Sandri, G, Mazzetti, M, Dipietralata, Mm, Lolli, R, Marchesini, G, Fava, A, Spadaro, Aldo, Paese, P, Belmonte, A, Graziani, Mg, Luminari, M, Accorsi, L, Boccia, S, Colella, F, Tamaro, G, Toigo, G, Pedretti, G, Fiaccadori, F, and Capocaccia, R.
- Published
- 1996
3. Paracentesis: a new needle for an old technique
- Author
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Boccia S, Macario F, Merighi A, Sergio Gullini, Rollo, and Accorsi L
- Subjects
Ascitic fluid ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Process improvement ,Ascites ,Punctures ,Surgery ,Needles ,medicine ,Paracentesis ,Drainage ,Humans ,medicine.symptom ,business ,Disposable Equipment - Abstract
The increasing use of paracentesis has prompted us to look into medical devices that might be useful for making the technique quicker and safer. Therefore we have designed a sterile, disposable, painless and safe needle that allows us to perform paracentesis in 30 patients, extracting an average of 6,000 cc of ascitic fluid in about 120 minutes, without any serious complications.
- Published
- 1991
4. Sclerosi endoscopica ed embolizzazione percutanea delle varici
- Author
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Boccia, S., Basso, O., Macario, F., Cantarini, A., Accorsi, L., Mannella, P., Galeotti, Roberto, Tartari, S., and Gullini, S.
- Published
- 1988
5. The relationship with patients in healthcare: Which workplace resources can lessen the impact of social stressor? | La relazione con i pazienti in sanità: Quali risorse lavorative per attenuare l'impatto degli stressor sociali?
- Author
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Guglielmetti, C., Gilardi, S., Accorsi, L., and Daniela Converso
6. Testing surgical face masks in an emergency context: The experience of italian laboratories during the COVID-19 pandemic crisis
- Author
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Fabiana Quaglia, Luca Accorsi, Stefano Stracquadanio, Gianluigi De Falco, Francesco Di Natale, Ivan Corradi, Fabrizia Helfer, Roberta Colicchio, Devid Maniglio, Nicola Paone, Filippo Caraci, Giandomenico Nollo, Sofia Cosentino, Marta Rigoni, Marina Mingoia, L. Montalto, Nunzio Tuccitto, Andrea D’Anna, Paolo Chiariotti, Paolo Castellini, Andrea Miraglia, Francesco Tessarolo, Ernesto Di Maio, L. Benedetti, Serena Simoni, Antonio Terrasi, Aurora Cuoghi, Salvo Baglio, Mario Musumeci, Alessia Tricomi, Paola Salvatore, Luigi Rovati, Luca Agostino Vitali, Leopoldo Angrisani, Alessia Baleani, Elena Veronesi, Ivo Iavicoli, Dezemona Petrelli, Mattia Piccini, Stefania Stefani, Alberto Ferrari, Giacomo Cuttone, Carlo Muscas, Tessarolo, F., Nollo, G., Maniglio, D., Rigoni, M., Benedetti, L., Helfer, F., Corradi, I., Rovati, L., Ferrari, A., Piccini, M., Accorsi, L., Veronesi, E., Cuoghi, A., Baglio, S., Tuccitto, N., Stefani, S., Stracquadanio, S., Caraci, F., Terrasi, A., Tricomi, A., Musumeci, M., Miraglia, A., Cuttone, G., Cosentino, S., Muscas, C., Vitali, L. A., Petrelli, D., Angrisani, L., Colicchio, R., D'Anna, A., Iavicoli, I., De Falco, G., Di Natale, F., Di Maio, E., Salvatore, P., Quaglia, F., Mingoia, M., Castellini, P., Chiariotti, P., Simoni, S., Montalto, L., Baleani, A., and Paone, N.
- Subjects
Bacterial filtration efficiency ,Covid-19 ,Differential pressure ,Masks ,Pandemic ,Sars-2 ,Standard testing ,Third mission ,COVID-19 ,Humans ,Italy ,Laboratories ,Pandemics ,Coronavirus disease 2019 (COVID-19) ,Computer science ,Health, Toxicology and Mutagenesis ,Population ,lcsh:Medicine ,Economic shortage ,Context (language use) ,010501 environmental sciences ,surgical masks ,01 natural sciences ,Article ,Settore MED/01 - Statistica Medica ,03 medical and health sciences ,0302 clinical medicine ,National level ,Operations management ,030212 general & internal medicine ,education ,0105 earth and related environmental sciences ,education.field_of_study ,Settore ICAR/03 - Ingegneria Sanitaria-Ambientale ,Mask ,testing method ,lcsh:R ,bacterial filtration efficiency ,differential pressure ,masks ,pandemic ,standard testing ,third mission ,Public Health, Environmental and Occupational Health ,Face masks ,Laboratorie ,Human - Abstract
The first wave of the COVID-19 pandemic brought about a broader use of masks by both professionals and the general population. This resulted in a severe worldwide shortage of devices and the need to increase import and activate production of safe and effective surgical masks at the national level. In order to support the demand for testing surgical masks in the Italian context, Universities provided their contribution by setting up laboratories for testing mask performance before releasing products into the national market. This paper reports the effort of seven Italian university laboratories who set up facilities for testing face masks during the emergency period of the COVID-19 pandemic. Measurement set-ups were built, adapting the methods specified in the EN 14683:2019+AC. Data on differential pressure (DP) and bacterial filtration efficiency (BFE) of 120 masks, including different materials and designs, were collected over three months. More than 60% of the masks satisfied requirements for DP and BFE set by the standard. Masks made of nonwoven polypropylene with at least three layers (spunbonded–meltblown–spunbonded) showed the best results, ensuring both good breathability and high filtration efficiency. The majority of the masks created with alternative materials and designs did not comply with both standard requirements, resulting in suitability only as community masks. The effective partnering between universities and industries to meet a public need in an emergency context represented a fruitful example of the so-called university “third-mission”.
- Published
- 2021
7. Hybrid biofabricated blood vessel for medical devices testing.
- Author
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Portone A, Ganzerli F, Petrachi T, Resca E, Bergamini V, Accorsi L, Ferrari A, Sbardelatti S, Rovati L, Mari G, Dominici M, and Veronesi E
- Abstract
Current in vitro and in vivo tests applied to assess the safety of medical devices retain several limitations, such as an incomplete ability to faithfully recapitulate human features, and to predict the response of human tissues together with non-trivial ethical aspects. We here challenged a new hybrid biofabrication technique that combines bioprinting and Fast Diffusion-induced Gelation strategy to generate a vessel-like structure with the attempt to spatially organize fibroblasts, smooth-muscle cells, and endothelial cells. The introduction of Fast Diffusion-induced Gelation minimizes the endothelial cell mortality during biofabrication and produce a thin endothelial layer with tunable thickness. Cell viability, Von Willebrand factor, and CD31 expression were evaluated on biofabricated tissues, showing how bioprinting and Fast Diffusion-induced Gelation can replicate human vessels architecture and complexity. We then applied biofabricated tissue to study the cytotoxicity of a carbothane catheter under static condition, and to better recapitulate the effect of blood flow, a novel bioreactor named CuBiBox (Customized Biological Box) was developed and introduced in a dynamic modality. Collectively, we propose a novel bioprinted platform for human in vitro biocompatibility testing, predicting the impact of medical devices and their materials on vascular systems, reducing animal experimentation and, ultimately, accelerating time to market., Competing Interests: No potential conflict of interest was reported by the author(s)., (© 2024 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis Group.)
- Published
- 2024
- Full Text
- View/download PDF
8. Novel bioprinted 3D model to human fibrosis investigation.
- Author
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Petrachi T, Portone A, Arnaud GF, Ganzerli F, Bergamini V, Resca E, Accorsi L, Ferrari A, Delnevo A, Rovati L, Marra C, Chiavelli C, Dominici M, and Veronesi E
- Subjects
- Animals, Humans, Fibrosis, Cell Differentiation physiology, Extracellular Matrix metabolism, Fibroblasts metabolism, Collagen Type I metabolism, Transforming Growth Factor beta metabolism
- Abstract
Fibrosis is shared in multiple diseases with progressive tissue stiffening, organ failure and limited therapeutic options. This unmet need is also due to the lack of adequate pre-clinical models to mimic fibrosis and to be challenged novel by anti-fibrotic therapeutic venues. Here using bioprinting, we designed a novel 3D model where normal human healthy fibroblasts have been encapsulated in type I collagen. After stimulation by Transforming Growth factor beta (TGFβ), embedded cells differentiated into myofibroblasts and enhanced the contractile activity, as confirmed by the high level of α - smooth muscle actin (αSMA) and F-actin expression. As functional assays, SEM analysis revealed that after TGFβ stimulus the 3D microarchitecture of the scaffold was dramatically remolded with an increased fibronectin deposition with an abnormal collagen fibrillar pattern. Picrius Sirius Red staining additionally revealed that TGFβ stimulation enhanced of two logarithm the collagen fibrils neoformation in comparison with control. These data indicate that by bioprinting technology, it is possible to generate a reproducible and functional 3D platform to mimic fibrosis as key tool for drug discovery and impacting on animal experimentation and reducing costs and time in addressing fibrosis., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Tiziana Petrachi, Alberto Portone, Gaelle Francoise Arnaud, Francesco Ganzerli, Valentina Bergamini, Elisa Resca, Luca Accorsi, Alberto Ferrari, Annalisa Delnevo, Luigi Rovati, Caterina Marra, Chiara Chiavelli, Massimo Dominici and Elena Veronesi DECLARE NO competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
9. A new strategy to prevent biofilm and clot formation in medical devices: The use of atmospheric non-thermal plasma assisted deposition of silver-based nanostructured coatings.
- Author
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Gallingani T, Resca E, Dominici M, Gavioli G, Laurita R, Liguori A, Mari G, Ortolani L, Pericolini E, Sala A, Laghi G, Petrachi T, Arnauld GF, Accorsi L, Rizzoli R, Colombo V, Gherardi M, and Veronesi E
- Subjects
- Mice, Animals, Coated Materials, Biocompatible chemistry, Anti-Bacterial Agents pharmacology, Biofilms, Silver chemistry, Metal Nanoparticles
- Abstract
In industrialized countries, health care associated infections, the fourth leading cause of disease, are a major health issue. At least half of all cases of nosocomial infections are associated with medical devices. Antibacterial coatings arise as an important approach to restrict the nosocomial infection rate without side effects and the development of antibiotic resistance. Beside nosocomial infections, clot formation affects cardiovascular medical devices and central venous catheters implants. In order to reduce and prevent such infection, we develop a plasma-assisted process for the deposition of nanostructured functional coatings on flat substrates and mini catheters. Silver nanoparticles (Ag NPs) are synthesized exploiting in-flight plasma-droplet reactions and are embedded in an organic coating deposited through hexamethyldisiloxane (HMDSO) plasma assisted polymerization. Coating stability upon liquid immersion and ethylene oxide (EtO) sterilization is assessed through chemical and morphological analysis carried out by means of Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). In the perspective of future clinical application, an in vitro analysis of anti-biofilm effect has been done. Moreover, we employed a murine model of catheter-associated infection which further highlighted the performance of Ag nanostructured films in counteract biofilm formation. The anti-clot performances coupled by haemo- and cytocompatibility assays have also been performed., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Gallingani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2023
- Full Text
- View/download PDF
10. Assessing Biocompatibility of Face Mask Materials during COVID-19 Pandemic by a Rapid Multi-Assays Strategy.
- Author
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Petrachi T, Ganzerli F, Cuoghi A, Ferrari A, Resca E, Bergamini V, Accorsi L, Burini F, Pasini D, Arnaud GF, Piccini M, Aldrovandi L, Mari G, Tomasi A, Rovati L, Dominici M, and Veronesi E
- Subjects
- Humans, Masks, SARS-CoV-2, Textiles, COVID-19, Pandemics
- Abstract
During the coronavirus disease 2019 (COVID-19) pandemic, scientific authorities strongly suggested the use of face masks (FMs). FM materials (FMMs) have to satisfy the medical device biocompatibility requirements as indicated in the technical standard EN ISO 10993-1:2018. The biologic evaluation must be confirmed by in vivo tests to verify cytotoxicity, sensitisation, and skin irritation. Some of these tests require an extensive period of time for their execution, which is incompatible with an emergency situation. In this study, we propose to verify the safety of FMMs combining the assessment of 3-[4,5-dimethylthiazolyl-2]-2,5-diphenyltetrazolium bromide (MTT) with quantification of nitric oxide (NO) and interleukin-6 (IL-6), as predictive markers of skin sensitisation or irritation based on human primary fibroblasts. Two hundred and forty-two FMMs were collected and classified according to spectrometer IR in polypropylene, paper, cotton, polyester, polyethylene terephthalate, 3-dimensional printing, and viscose. Of all FMMs tested, 50.8% passed all the assays, 48% failed at least one, and only 1.2% failed all. By a low cost, rapid and highly sensitive multi assays strategy tested on human skin fibroblasts against a large variety of FMMs, we propose a strategy to promptly evaluate biocompatibility in wearable materials.
- Published
- 2021
- Full Text
- View/download PDF
11. Testing Surgical Face Masks in an Emergency Context: The Experience of Italian Laboratories during the COVID-19 Pandemic Crisis.
- Author
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Tessarolo F, Nollo G, Maniglio D, Rigoni M, Benedetti L, Helfer F, Corradi I, Rovati L, Ferrari A, Piccini M, Accorsi L, Veronesi E, Cuoghi A, Baglio S, Tuccitto N, Stefani S, Stracquadanio S, Caraci F, Terrasi A, Tricomi A, Musumeci M, Miraglia A, Cuttone G, Cosentino S, Muscas C, Vitali LA, Petrelli D, Angrisani L, Colicchio R, D'Anna A, Iavicoli I, De Falco G, Di Natale F, Di Maio E, Salvatore P, Quaglia F, Mingoia M, Castellini P, Chiariotti P, Simoni S, Montalto L, Baleani A, and Paone N
- Subjects
- Humans, Italy, COVID-19 prevention & control, Laboratories, Masks standards, Pandemics
- Abstract
The first wave of the COVID-19 pandemic brought about a broader use of masks by both professionals and the general population. This resulted in a severe worldwide shortage of devices and the need to increase import and activate production of safe and effective surgical masks at the national level. In order to support the demand for testing surgical masks in the Italian context, Universities provided their contribution by setting up laboratories for testing mask performance before releasing products into the national market. This paper reports the effort of seven Italian university laboratories who set up facilities for testing face masks during the emergency period of the COVID-19 pandemic. Measurement set-ups were built, adapting the methods specified in the EN 14683:2019+AC. Data on differential pressure (DP) and bacterial filtration efficiency (BFE) of 120 masks, including different materials and designs, were collected over three months. More than 60% of the masks satisfied requirements for DP and BFE set by the standard. Masks made of nonwoven polypropylene with at least three layers (spunbonded-meltblown-spunbonded) showed the best results, ensuring both good breathability and high filtration efficiency. The majority of the masks created with alternative materials and designs did not comply with both standard requirements, resulting in suitability only as community masks. The effective partnering between universities and industries to meet a public need in an emergency context represented a fruitful example of the so-called university "third-mission".
- Published
- 2021
- Full Text
- View/download PDF
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