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Three radiation detection tools were employed to assess natural radiation levels in Mamuju Regency, West Sulawesi, Indonesia. These tools comprised the NaI(Tl) Scintillator, the Geiger Muller Counter (GMC), and the Electronic Personal Dosimeter (EPD). The NaI(Tl) Scintillator and GMC measured ambient dose equivalent (H*(10)), while the EPD exclusively gauged personal dose equivalent (Hp(10)). A total of 75 measuring points were designated for assessment. Results from H*(10) measurements indicated that the GMC recorded an average H*(10) 41% higher than that of the NaI(Tl) Scintillator, with specific rates of 0.769 µSv/h and 0.457 µSv/h, respectively. Both instruments exhibited proficiency in detecting elevated levels of radiation. Discrepancies in the outcomes were attributed to differences in detector type and efficiency. The GMC, equipped with an energy-compensated detector, demonstrated enhanced efficiency compared to the NaI(Tl) Scintillator, particularly when subjected to high energy flux radiation. Anomalies emerged in the Hp(10) measurements, which surpassed the H*(10) measurements. This difference is due to the EPD's use of a conventional GM detector, which is capable of detecting gamma, beta, and X-ray radiation. [ABSTRACT FROM AUTHOR]

Mangrove seedlings are exposed to several environmental stress factors, which frequently affect the current state of their ecosystems. We examined the density, diversity, distribution, survival rates, and biophysical parameters of over 900 naturally existing seedlings in natural, degraded, and restored coastline ecosystems in Guyana. Systematic sampling was conducted for 1 year following the point-centred quarter method (PCQM) during the wet and dry seasons. The restored ecosystems had greater seedling densities (1546.44–5506.303 individuals/ha), diversity (0.65–0.65), and richness (0.46–0.51) when compared to the natural and degraded ecosystems. Seedling survival rates [41.9–53.4%] were greater in the natural ecosystems, but short-term seasonal variations were prevalent in the restored ecosystems. Significant disparities were observed in seeding biophysical parameters [df = 8, p

In mangrove forests, one of the most noticeable characteristics is the unique interplay between soil and water, which facilitates the movement of nutrients and sediments throughout their ecosystems. In this study, comparisons were made between the physicochemical characteristics of soil (pH, EA, OC, EC, N, P, K, Mg, Ca, S, Fe, Zn, Cu, and Mn) and water (pH, temperature, and electrical conductivity) found in natural, degraded, and restored mangrove ecosystems along the coastline of Guyana. Sampling was done using a Random Block Design (RBD) in six study sites for six months. This study revealed that there were no significant variations in most of the physicochemical parameters found in soil and water within ecosystem type or season. However, notable differences were seen in the pH of water (6.45–7.88), as well as Fe (0.60–21.62 ppm, p 0.75) showed higher associations between soil physicochemical properties concerning ecosystem types, when compared to water parameters.

Abstract Mangrove leaves have unique features that enable them to cope with shifting environmental conditions while preserving their general functionality and efficiency. We examined the morphological characteristics and chlorophyll content (spectroscopically) of 600 mature Avicennia germinans leaves selected from 30 trees located in one degraded, one restored, and one natural mangrove ecosystem along Guyana's coastline. Systematic sampling was carried out using the closest individual sampling method in the wet and dry seasons. We hypothesized that both habitat type and seasonality influence the leaf traits and chlorophyll content of A. germinans. Our findings showed that A. germinans leaves are mesophyllous, and traits such as leaf perimeter, area, length, width, dry mass, wet mass, turgid mass, leaf‐specific area, and relative water content showed fluctuations in ecosystems (one‐way ANOVA, p .75) were also established for over 10 leaf parameters in both seasons while PCA and multiple regression analyses further confirmed the strong relationships between leaf morphological features and their respective locations. Changes in chlorophyll concentration were most noticeable in the degraded ecosystem while variations in leaf traits were more pronounced in the restored mangrove area. This may be due to the various disturbances found in each ecosystem coupled with fluctuations in the seasons. Our results demonstrate that mangroves, to some extent, alter their plant structures to cope with environmental stressors present in the various ecosystems they thrive in to maintain their survival.

This study reviewed the state-of-the-art knowledge on Nypa fruticans-based (hereafter Nypa-based) land use along with the corresponding ecosystem services that contribute to the wellbeing of mangrove-dependent communities (MDCs) in the tropics. In relation to the land uses, Nypa’s ecosystem service valuation, restoration potential and threats were also explored. Nypa-based land uses documented in tropical countries since the last century include, Natural Nypa Forests (NNF), Nypa Plantations (NP), Nypa-Aquaculture Systems (NAS), and Nypa-Agriculture Systems (NAgS). Even though land use-specific variations were found in distribution, abundance, and ecosystem services provided, it appears that there is the great overlap of reported ecosystem services regardless of Nypa land use. The provisioning ecosystem services of Nypa have been made use of at the subsistence level by man for millennia. These especially include its use as a source of food, fuel, and fiber. Nypa is unique among the many mangroves as being about the only one that has significantly been developed for commercial exploitation beyond the typical destructive harvest for wood and charcoal as seen in most other mangroves. Our review presents new research that has made important inroads in exploring Nypa’s yet untapped commercial potential for livelihood provisioning for poor MDCs. Building further on these pioneering results holds major promise for the development of new sustainable livelihood opportunities for MDCs. The review also shows that Nypa provides substantial supporting, regulating and cultural services. These services have been rarely studied, and Nypa’s contribution to the wellbeing of MDCs are therefore not well-acknowledged. Our review also suggests that at the landscape level, Nypa also holds major promise as a way to rapidly sequester atmospheric carbon dioxide, protect coastal areas from weather extremes, rehabilitate abandoned aquaculture ponds and transform aquaculture towards greater sustainability. Therefore, we recommend further intensification of Nypa-based land uses in conjunction with the further development of value-added Nypa products for livelihood support, as well as basic research on the ecological niche-specific suitability of Nypa-based land uses, and their associated ecosystem services.

IntroductionGuillain–Barré syndrome (GBS) is a rare disease that affects almost 0.8–1.9 cases per 100,000 people worldwide every year. This is the most prevalent cause of subacute flaccid paralyzing illness today. It is a subacute inflammatory demyelinating polyradiculoneuropathy; the typical scenario involves ascending symmetrical flaccid paralysis, but in some circumstances, sensory, autonomic, and cranial neuropathy may also be involved. Several vaccines have been found to have complications since the previous century. Numerous case reports of GBS in the literature have been reported following COVID-19 vaccines in recent times.ObjectiveThis study aimed to conduct a comprehensive examination of GBS cases that have been reported after COVID-19 vaccines; to analyze the descriptive statistical analysis of data gathered regarding clinical, laboratory, electrophysiological, and radiological characteristics; to discuss, based on the available evidence, whether the disease has a preference for a particular vaccine type; and to speculate on the potential pathogenesis.MethodologyThis review has been carried out by recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.ResultReviewing 60 case reports illustrated that most of them are from the USA (18.1%) and the majority of affected individuals were males (60%). The results favored the association between vector-based SARS-CoV-2 vaccine, particularly AstraZeneca vaccine, and the GBS. The mean of symptoms onset is 11.4 days. The results of diagnostic tests such as LP are consistent mostly with albumin-cytological dissociation (81.81%), where brain and spine MRI was unremarkable in 59.52%. Regarding electrodiagnostic tests, AIDP is the most common variant (61.81%). The management was not consistent among the case reports. However, IVIG is the most frequent way of treating these patients (68.33%). The functional outcome was documented in 47 patients; 65% improved with medical management.ConclusionThis study aimed to conduct a systematic review of reported cases of GBS following COVID-19 vaccines and descriptive statistical analysis of collected data on clinical, laboratory, electrophysiological, and radiological features, to discuss, based on available results, whether the disease has a predilection to a specific vaccine type and to speculate the potential pathogenesis.

Abstract Microbial proteases are one of the most demanding enzymes for various industries with diverse applications in food, pharmaceutics, and textile industries to name the few. An extracellular alkaline metalloprotease was produced and purified from moderate halophilic bacterial strain, Bacillus cereus TS2, with some unique characteristics required for various industrial applications. The protease was produced in basal medium supplemented with casein and was partially purified by ion exchange chromatography followed by ammonium sulphate precipitation. The alkaline metalloprotease has molecular weight of 35 kDa with specific activity of 535.4 µM/min/mg. It can work at wide range of pH from 3 to 12, while showing optimum activity at pH 10. Similarly, the alkaline metalloprotease is stable till the temperature of 80 °C and works at wide range of temperature from 20 to 90 °C with optimum activity at 60 °C. The turnover rate increases in the presence of NaCl and Co+2 with k cat/KM of 1.42 × 103 and 1.27 × 103 s-1.M-1 respectively, while without NaCl and Co+2 it has a value of 7.58× 102. The alkaline metalloprotease was relatively resistant to thermal and solvent mediated denaturation. Applications revealed that the metalloprotease was efficient to remove hair from goat skin, remove blood stains and degrade milk, thus can be a potential candidate for leather, detergent, and food industry.

Purpose The purpose of this study was to to produce vermiwash and vermicompost using organic waste material and study its effect on the growth, development and yield of tomato plants(Lycopersicon esculentum Mill.) in field condition. Method The experiment was carried out in two phases: the production of vermicompost followed by vermiwash using Eisenia foetida earthworms and the cultivation of tomato plants using the same. In the first phase of production of vermicompost, three types of organic waste (dry grass clippings, dry neem leaves and a combination of dry grass clippings and dry neem leaves) were utilized with three replications. The second phase consisted of a Randomized Block Design (RBD) with four treatments and three replications in the field condition. The treatments were control (C), vermicompost (V), vermiwash (W) and a combination of vermicompost and vermiwash (VW).ResultsThe results revealed that the vermicompost produced had a dark color, finely divided peat-like material, with desirable soil odor and a fine smooth texture and an adequate nutritional value, which was confirmed to have good quality. The vermiwash produced from the different vermicomposting bins was brownish colour liquid and had all the essential macro and micro-nutrients. The combination of vermicompost and vermiwash (0.05 kg + 0.05 l) significantly (p < 0.05) resulted in the highest yield followed by vermiwash (0.1 l) and vermicompost (0.1 kg).Conclusion The combination of vermicompost and vermiwash as a bio-fertilizer had a positive effect on the plant growth parameters and production of the tomato plants.

Purpose Organic waste is a serious concern across the globe contributed by human activity that can be managed by efficient process like vermicomposting which can reduce the waste that is dumped in landfills into useful product vermicompost. This research was conducted to study the bio-conversion of organic waste (fruit and vegetable waste) using Perionyx excavatus into quality vermicompost. Method Three organic waste treatments were used for the vermicomposting process: FW [Fruit waste + Cow Dung], VW [Vegetable waste + Cow Dung], FVW [Fruit waste + Vegetable waste + Cow Dung]. A control group was set up without earthworms for each treatment. The compost was harvested after 38 days, weighed and the rate of production per day was calculated. The harvested compost was then subjected to physico-chemical analysis to determine the nutrient status. Results The experimental group had a significant rate of production with higher quantity than the control groups. Vermicompost produced from vegetable waste was 515.45 g (51.55%) which was the highest among all the treatments. The lowest amount of compost was produced by the Fruit + Vegetable waste treatment in the control group (184.16 g). The nutrient status was within the acceptable range for the experimental groups. Conclusion Epigeic earthworm Perionyx excavatus is highly efficient in reducing organic waste (fruit and vegetable waste) into vermicompost enriched with nutrients necessary for plant growth.

The aim of this study was to compare the antibiotic potency of Cyanthillium cinereum and Moringa oleifera (natural antibiotics) against Ampicillin and Erythromycin (synthetic antibiotics) using zone of inhibition and both the natural and synthetic antibiotic was treated against Staphylococcus aureus, Klebsiella. pneumoniae and Pseudomonas aeruginosa. The extracts from the natural agents were obtained by the use of methanol (polar) and hexane (non-polar). The bacteria were treated with six different conc. (100%, 75%, 50%, 25%, 10% and 5%) of the extracts, where the largest zone of inhibition was observed with C. cinereum extract at 5% concentration against S. aureus with mean and standard deviation of 22.1±2.1. S. aureus followed by P. aeruginosa was most susceptible towards the treatments. The correlation (Pearson) indicated that the conc. of the extract was indirectly proportional to the zone of inhibition. The phytochemical analysis revealed that C. cinereum contained alkaloids, catecholic tannins, saponins, flavones, volatile oils phenols and steroids and M. oleifera only contained Alkaloid, tannins and steroids.

Abstract Purpose The present research was conducted with the objective of exploring the vermicomposting process, which involves different stages such as building of a vermicompost station; import of a compost earthworm (Eisenia foetida); and production of vermicompost using dry grass clippings, rice straw and cow manure. The vermicompost produced can be of significant value to the end users like farmers for replacement of chemical fertilizers and procuring better prices for the organic produce using such composting material locally available at much lower cost. Methods Vermicomposting was done using Eisenia foetida with three treatments [T1 (Rice straw), T2 (Rice straw + grass) and T3 (Grass)]. Temperature, humidity and pH were measured during the process. The population of earthworms, the production of vermicompost, and the chemical and microbial characteristics of the vermicompost were recorded after sixty (60) days and hundred twenty (120) days. The data were analyzed statistically using Sigma Plot 12.0. Results Results indicated that for all the three treatments the temperature was in the range of 0–35 °C, the humidity was between 80 and 100% and the pH fluctuated in the range of 5.5–7.0 and stabilized to near neutral on the 60th day. The combination of rice straw and grass had the highest rate of vermicompost production of 105 kg/m2 followed by grass and rice straw with 102.5 kg/m2 and 87 kg/m2, respectively, at the end of 120 days. Conclusion The harvested vermicompost had an excellent nutrient status, confirmed by the chemical analyses, and contained all the essential macro- and micronutrients.

Bu araştırmanın amacı, pedagojik formasyon temelli alan öğretmenlerinin öğretme-öğrenme sürecine ilişkin yeterlik düzeylerini belirlemektir. Çalışma, Pedagojik Formasyon Sertifika Programına kayıtlı 87 öğrencinin sekiz hafta boyunca altı okulda yaptıkları gözlemlere dayalı olarak gerçekleştirilmiştir. Gözlemin nasıl yapılacağına ilişkin eğitilen öğretmen adayları aracılığıyla toplanan verilere göre, alan öğ- retmenleri; dersin giriş etkinliklerini ara sıra, geliştirme ve sonuç etkinliklerini ise her zaman gerçekleş- tirmektedirler. Öğretmenler, derslerde en çok düz anlatım yöntemini en az ise örnek olay yöntemini kullanmayı tercih etmektedirler. Öğretmenler öğretme-öğrenme sürecinde, eğitim araçlarında ise en çok yazı tahtasını en az ise gerçek nesneler ve modelleri kullanmaktadırlar.

Cartoons have widely been being used as an alternate approach for determining individuals' perceptions recently. Within this respect, study aims at determining secondary school students' perception about the social unity and solidarity values via cartoons. The participants of the study conducted as a qualitative research design and as a case study are 100 students from two different schools in two cities. The data of the study were collected through a data sheet consisted of a cartoon and four questions related to the cartoon. For analysing the data content analysis technique was administered and in this framework, the themes for each questions were defined. Frequencies for themes and subthemes were used for interpretations. The findings revealed that the great majority of the participants got the message of the cartoon correctly, felt sympathy, sorrow, unity and solidarity, love and respect, hope, peace, separation, and longing about the cartoon. The findings also manifested that the participants remarked the main values in the cartoon as social unity and solidarity, fellowship, friendship and social relations. Finally, the results indicated that they interpreted the message of the cartoon mostly with the proverbs such as “united we stand united we are stronger”, “many hands make light work”, and “no one is rich enough to do without his neighbour”. As a result, the study revealed that the students understood the message of the cartoons correctly, supported their perceptions with the right words and proverbs, and also revealed that use of cartoons are strong alternative approach if used properly.

Bu araştırmanın temel amacı öğretmenlerin Okul Temelli Mesleki Gelişim Modeline ilişkin görüşlerinin belirlenmesidir. Tarama modelinde yürütülen araştırmanın çalışma grubunu farklı alanlardan 114 ilköğretim öğretmeni oluşturmaktadır. Araştırma verileri Öz-değerlendirme anketi ile toplanmıştır. Toplanan verilerin çözümünde betimsel istatistiklerden (aritmetik ortalama, standart sapma),t testinden ve tek yönlü varyans analizinden yararlanılmıştır. Bulgular öğretmenlerin cinsiyetlerinin OTMG modeline ilişkin görüşlerinde farklılığa neden olduğunu; ölçeğin genelinde bayan öğretmenlerin Meslek Değerler ve Etik Davranışlar boyutunda erkek öğretmenlerin, Öğretme-Öğrenme Sürecine İlişkin Beceri, Ölçme-Değerlendirme Becerileri ve Özel Alan Becerileri boyutunda bayan öğretmenlerin daha olumlu görüşlere sahip olduğunu ortaya koymuştur. Bulgular ayrıca Çevre etkileşimi ve Veli iletişim boyutlarında beceriye dayalı alan öğretmenlerinin diğer alanlardan daha düşük olduğu belirlenmiştir. Araştırma kapsamında önerilerde bulunulmuştur.

Abstract Background Home blood pressure monitoring (HBPM) is gaining popularity among hypertensive patients. This study aimed to explore the influence of self-initiated HBPM on primary care patients with hypertension. Methods Six in-depth interviews and two focus group discussions were conducted, taking into consideration the experiences of 24 primary care patients with hypertension. These patients had been using HBPM as part of their hypertension management. The overriding influences were grouped under themes which emerged from analyzing the data using the grounded theory approach. Results There are both positive and negative influences of self-initiated HBPM. Patients used the readings of their HBPM to decide on many aspects of their hypertension management. The HBPM readings both influenced their adherence to diet and exercise and provided certain reassurance when they experienced symptoms. In addition, the act of discussing their HBPM readings with their health care providers resulted in an enhanced doctor-patient therapeutic relationship. Nevertheless, HBPM created confusion at times in some patients, particularly with regard to the target blood pressure level and the need for medication. This led to some patients making their own medical decisions based on their own standards. Conclusions HBPM is becoming an integral part of hypertension management. Primary care patients who self-initiated HBPM reported being more self-efficacious, but lack of participation and guidance from their doctors created confusion, and hindered the true benefit of HBPM.

As the number of infections and deaths attributable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to rise, it is now becoming apparent that the health impacts of the Coronavirus disease (COVID-19) may not be limited to infection and the subsequent resolution of symptoms. Reports have shown that patients with SARS-CoV-2 infection may experience multiple symptoms across different organ systems that are associated with adverse health outcomes and develop new cardiac, renal, respiratory, musculoskeletal, and nervous conditions, a condition known as Long COVID or the post-acute sequelae of COVID-19 (PASC). This review provides insights into distinct subphenotypes of Long COVID and identifies microbiota dysbiosis as a common theme and crucial target for future therapies. Another important finding is that Long COVID is associated with prolonged and increased inflammation, potentially attributable to immune system dysfunction. A promising solution lies in the potential of probiotics to mitigate Long COVID symptoms by restoring gut microbiota balance and modulating the immune response. By evaluating the current clinical development landscape of the use of probiotics to treat Long COVID symptoms, this paper provides recommendations for future research by stressing the need to understand the modulation of bacterium strains followed by probiotic therapy to understand the association of microbiota dysbiosis with Long COVID symptoms. This will facilitate the development of effective probiotic formulations that could serve as reliable therapies against Long COVID., Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest., (Copyright © 2025 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)

Memory loss is becoming an increasingly significant health problem, largely due to Alzheimer's disease (AD), which disrupts the brain in several ways, including causing inflammation and weakening the body's defenses. This study explores the potential of medicinal plants as a source of novel therapeutic agents for AD. First, we tested various plant extracts against acetylcholinesterase (AChE) in vitro , following molecular docking simulations with key AD-related protein targets such as MAO-B, P-gp, GSK-3β, and CD14. Rosemary extract was found to be the most inhibitory towards AChE. The compounds found in rosemary (oleanolic acid), sage (pinocembrin), and cinnamon (italicene) showed promise in potentially binding to MAO-B. These chemicals may interact with a key protein in the brain and alter the production and removal of amyloid-β. Luteolin (from rosemary), myricetin (from sage), chamigrene, and italicene (from cinnamon) exhibited potential for inhibiting tau aggregation. Additionally, ursolic acid found in rosemary, sage, and chamigrene from cinnamon could modulate CD14 activity. For the first time, our findings shed light on the intricate interplay between neuroinflammation, neuroprotective mechanisms, and the immune system's role in AD. Further research is needed to validate the in vivo efficacy and safety of these plant-derived compounds, as well as their interactions with key protein targets, which could lead to the development of novel AD therapeutics., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Author(s).)

Cancer is one of the major leading causes of mortality globally and chemo-drug-resistant cancers pose significant challenges to cancer treatment by reducing patient survival rates and increasing treatment costs. Although the mechanisms of chemoresistance vary among different types of cancer, cancer cells are known to share several hallmarks, such as their resistance to apoptosis as well as the ability of cancer stem cells to produce metastatic daughter cells that are resistant to chemotherapy. To address the issue of chemo-drug resistance in cancer cells, a tetracistronic expression construct, Ad-MBR-GFP, encoding adenovirus-mediated expression of MOAP-1, Bax, RASSSF1A, and GFP, was generated to investigate its potential activity in reducing or inhibiting the chemo-drug resistant activity of the human breast cancer cells, MCF-7-CR and MDA-MB-231. When infected by Ad-MBR-GFP, the cancer cells exhibited round cell morphology and nuclei condensation with positive staining for annexin-V. Furthermore, our results showed that both MCF-7-CR and MDA-MB-231 cells stained positively for CD 44 and negatively for CD 24 (CD44+/CD24-) with high levels of endogenous ALDH activity whereas SNU-1581 breast cancer cells were identified as CD 44-/CD 24- cells with relatively low levels of endogenous ALDH activity and high sensitivity toward chemo-drugs, suggesting that both CD 44 and ALDH activity contribute to chemo-drug resistance. Moreover, both MCF-7-CR and MDA-MB-231 cells showed strong chemo-drug sensitivity to cisplatin when the cells were infected by Ad-MBR-GFP, leading to 9-fold and 2-fold reduction in the IC 50 values when compared to cisplatin treatment alone, respectively. The data were further supported by 3D (soft agar) and spheroid cell models of MCF-7-CR and MDA-MB-231 cells which showed a 2-fold reduction of a number of cell colonies and spheroid size when treated with both Ad-MBR-GFP and cisplatin, and compared to control. Other than chemo-sensitivity, Ad-MBR-GFP-infected cancer cells retarded cell migration. Flow cytometry analysis showed that the mechanism of action of Ad-MBR-GFP involved cell cycle arrest at the G1 phase and inhibition of cellular DNA synthesis. Taken together, our investigation showed that Ad-MBR-GFP mediated chemo-drug sensitization in the infected cancer cells involved the activation of apoptosis signaling, cell cycle arrest, and inhibition of DNA synthesis, suggesting that Ad-MBR-GFP is potentially efficacious for the treatment of chemo-drug resistant cancers., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)

Two-dimensional (2D) nanomaterials have garnered enormous attention seemingly due to their unusual architecture and properties. Graphene and graphene oxide based 2D nanomaterials remained the most sought after for several years but the quest to design superior 2D nanomaterials which can find wider application gave rise to development of non-graphene 2D materials as well. Consequently, in addition to graphene based 2D nanomaterials, 2D nanostructures designed using macromolecules (such as DNAs, proteins, peptides and peptoids), transition metal dichalcogenides, transition-metal carbides and/or nitrides (MXene), black phosphorous, chitosan, hexagonal boron nitrides, and graphitic carbon nitride, and covalent organic frameworks have been developed. Interestingly, these 2D nanomaterials have found applications in diagnosis and treatment of various diseases including Alzheimer's disease (AD). Although AD is one of the most debilitating neurodegenerative conditions across the globe; unfortunately, there remains a paucity of effective diagnostic and/or therapeutic intervention for it till date. In this scenario, nanomaterial-based biosensors, or therapeutics especially 2D nanostructures are emerging to be promising in this regard. This review summarizes the diagnostic and therapeutic platforms developed for AD using 2D nanostructures. Collectively, it is worth mentioning that these 2D nanomaterials would seemingly provide an alternative and intriguing platform for biomedical interventions., Competing Interests: Declaration of Competing Interest There are none, (Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)

Background: Screening new natural molecules with pharmacological and/or cosmetic properties remains a highly sought-after area of research. Moreover, essential oils and volatile compounds have recently garnered significant interest as natural substance candidates. In this study, the volatile components of Pistacia lentiscus L. essential oils (PLEOs) isolated from the fruit and its main compounds, alpha-pinene, and limonene, are investigated for antioxidant, antidiabetic, and dermatoprotective activities., Methods: In vitro antioxidant activity was investigated using 2,2'-diphenyl-1-picrylhydrazyl (DPPH), fluorescence recovery after photobleaching (FRAP), and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) methods. The antidiabetic and dermatoprotective effects were studied using enzyme inhibitory activities., Results: Antioxidant tests showed that PLEO has the best activity (ranging from 29.64 ± 3.04 to 73.80 ± 3.96 µg/mL) compared to its main selected molecules (ranging from 74 ± 3.72 to 107.23 ± 5.03 µg/mL). The α-glucosidase and α-amylase assays demonstrated that the elements tested have a promising antidiabetic potential with IC50values ranging from 78.03 ± 2.31 to 116.03 ± 7.42 µg/mL and 74.39 ± 3.08 to 112.35 ± 4.92 µg/mL for the α-glucosidase and α-amylase assays, respectively, compared to the standard drug. For the tyrosinase test, we found that the EOs (IC50 = 57.72 ± 2.86 µg/mL) followed by limonene (IC50 = 74.24 ± 2.06 µg/mL) and α-pinene (IC50 = 97.45 ± 5.22 µg/mL) all exhibited greater inhibitory effects than quercetin (IC50 = 246.90 ± 2.54 µg/mL)., Conclusions: Our results suggest that the biological activities of PLEO, as well as its main compounds, make them promising candidates for the development of new strategies aimed at improving dermatoprotection and treating diseases associated with diabetes mellitus and oxidative stress., Competing Interests: The authors declare no conflict of interest., (© 2023 The Author(s). Published by IMR Press.)