39 results on '"Abdul Hamid Z"'
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2. Synthesis of silver nanoparticle-decorated hydroxyapatite nanocomposite with combined bioactivity and antibacterial properties
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Bee, Soo-Ling, Bustami, Yazmin, Ul-Hamid, A., Lim, Keemi, and Abdul Hamid, Z. A.
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- 2021
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3. Osteoblasts migration, attachment and human bone marrow-mesenchymal stem cells osteogenic differentiation towards surface engineered and growth factors conjugated poly(lactic acid) microspheres
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Mohd Sabee, M. M. S., Kamalaldin, N. A., Yahaya, B. H., and Abdul Hamid, Z. A.
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- 2020
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4. Preparation and optimization of surface-engineered poly(lactic acid) microspheres as a drug delivery device
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Abdul Hamid, Z. A., Tham, C. Y., and Ahmad, Z.
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- 2017
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5. Hydrogel Scaffolds: Advanced Materials for Soft Tissue Re-growth
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Abdul Hamid, Z. A., Blencowe, A., Palmer, J., Abberton, K. M., Morrison, W. A., Penington, A. J., Qiao, G. G., Stevens, G., Magjarevic, Ratko, editor, Osman, Noor Azuan Abu, editor, Abas, Wan Abu Bakar Wan, editor, Wahab, Ahmad Khairi Abdul, editor, and Ting, Hua-Nong, editor
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- 2011
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6. Expert eValuation of Efficacy and Rationality of Vildagliptin 'EVER-Vilda': An Indian Perspective
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Sanjay Kalra, Abdul Hamid Zargar, GR Sridhar, Ashok Kumar Das, Jamal Ahmed, Jagdish Chander Mohan, G Vijayakumar, Ajay Kumar, Rakesh Kumar Sahay, Vageesh Ayer, Kaushik Pandit, Ganapathi Bantwal, Arun Srinivas, AG Unnikrishnan, Sushil Jindal, Saumitra Ray, Manash P Baruah, Kajal Ganguly, Sachin Mittal, Ameya Joshi, Joe George, Ganesh HK, Nitin Kapoor, Santosh Ramakrishnan, Chetan Shah, Atul Dhingra, and Balram Sharma
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Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor is effective in reducing HbA1c levels in patients with type 2 diabetes (T2DM) when administered as monotherapy, dual or triple combination therapy. In India, Vildagliptin is commonly prescribed in T2DM patients because it reduces mean amplitude of glycemic excursion (MAGE), has lower risk of hypoglycemia and is weight neutral. Early combination therapy with vildagliptin and metformin is effective and well-tolerated in patients with T2DM, regardless of age or ethnicity. In view of already existing data on vildagliptin and the latest emerging clinical evidence, a group of endocrinologists, diabetologists and cardiologists convened for an expert group meeting to discuss the role and various combinations of vildagliptin in T2DM management. This practical document aims to guide Physicians and Specialists regarding the different available strengths and formulations of vildagliptin for the initiation and intensification of T2DM therapy.
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- 2024
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7. محددات تدفق الإستثمار الأجنبي المباشر دراسة قياسية تحليلية لعينة من الدول النامية للمدة (1996-2020)
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Omar Hassan and Abdul Hamid Zahir
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الإستثمار الأجنبي المباشر ,الدول النامية ,دول ذات الدخل المتوسط الأعلى ,الناتج المحلي الإجمالي ,History of scholarship and learning. The humanities ,AZ20-999 ,Language and Literature - Abstract
تهدف هذه الدراسة الى قياس العوامل المحددة للإستثمار الأجنبي المباشر في الدول النامية ذات الدخل المتوسط الاعلى ضمن تصنيفات الدخل للبنك الدولي وتشمل خمسة دول وهي (المكسيك, البرازيل, ماليزيا, رومانيا والصين) للمدة 1996-2020. ولغرض التعرف على اهم عوامل جذب هذا النوع من الاستثمار في هذه الدول إعتمدت الدراسة على الأسلوب الكمي بإستخدام نموذج الإنحدار الذاتي للإبطاء الموزع والمتعلق بمعطيات بيانات البانل المتوازنة (Panel-ARDL) وذلك لتقدير معلمات تلك العوامل المحددة تدفق الإستثمار الأجنبي المباشر على المديين القصير والطويل والمتمثلة في كل من (معدل نمو الناتج المحلي الإجمالي, الاستقرار السياسي, إجمالي تكوين رأس المال, معدل التضخم وسعر الصرف). وتبين من نتائج الدراسة بأنه على المدى القصير لا يوجد تأثير معنوي ذو دلالة احصائية بين الإستثمار الأجنبي المباشر والمتغيرات المفسرة له, أما نتائج التقدير على المدى الطويل لقد أظهرت علاقة إيجابية ذات تأثير معنوي بين الإستثمار الأجنبي المباشر وكل من معدل نمو الناتج المحلي الإجمالي والاستقرار السياسي وإجمالي تكوين رأس المال في دول عينة الدراسة خلال المدة التي غطتها الدراسة. اما المتغيرات التي أثرت بشكل سلبي على الإستثمار الأجنبي المباشر فهما كل من متغير سعر الصرف ومعدل التضخم, فالأول كان ذات تأثير سلبي ومعنوي أما الثاني فكان ذو اثر سلبي ولكن غير معنوي, وكان متغير معدل نمو الناتج المحلي الاجمالي هو الأكثر تأثيرا في جذب الإستثمار الأجنبي المباشر, وتقترح الدراسة بأنه على دول الدراسة ان تواصل خطواتها في إطار المحافظة على الاستقرار الإقتصادي, وإعداد خطة إستثمارية شاملة وواقعية لجميع الفرص الاستثمارية, وكذلك العمل على إستقرار الأوضاع السياسية والتي تعد من العوامل المهمة في تحقيق الحجم المرغوب لتدفق رؤوس الأموال الأجنبية في دول الدراسة.
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- 2023
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8. Preparation and optimization of surface-engineered poly(lactic acid) microspheres as a drug delivery device.
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Abdul Hamid, Z. A., Tham, C. Y., and Ahmad, Z.
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POLYLACTIC acid ,CHEMICAL sample preparation ,DRUG delivery devices ,MATHEMATICAL optimization ,HYDROLYSIS ,SURFACE chemistry ,FUNCTIONAL groups ,FOURIER transform infrared spectroscopy - Abstract
One of the challenges in using poly(lactic acid) (PLA) as a drug delivery device is its lack of active functional groups and its hydrophobic nature. Therefore, a simple and feasible hydrolysis treatment using sodium hydroxide (NaOH) and hydrochloric acid (HCL) at different concentrations and treatment durations was utilized to modify the PLA microspheres' surface hydrophobicity. In this research, we report the chemical and morphological changes of surface-engineered PLA microspheres/films with regard to its integrity as a drug delivery carrier. After the hydrolysis treatment, Fourier transform infrared spectroscopy results confirmed that there were chemical changes in the surface-engineered PLA microspheres as they changed from being hydrophobic to hydrophilic; additionally, an increase in -OH functional group was also detected. This change is also indicated by the increase in hydrophilicity of the bulk surface as illustrated by XPS analysis, contact angle, and zeta potential measurements. These results suggest that the hydrolysis treatment is a feasible way to change the surface properties of PLA microspheres to become more compatible with biological environment and to increase the amount of active functional sites. However, the bulk morphology changed from smooth to porous structure after 48 h and started to degrade after prolonged hydrolysis treatment. Thus, this work underlines the importance of controlling the hydrolysis treatment so as not to compromise the bulk morphology and integrity of PLA microspheres while enhancing its hydrophilicity. [ABSTRACT FROM AUTHOR]
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- 2018
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9. IMPACT India: A novel approach for optimum diabetes care
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Ashok K Das, Viswanathan Mohan, Shashank Joshi, Siddharth Shah, Abdul Hamid Zargar, Sanjay Kalra, Ambika Gopalakrishnan Unnikrishnan, Ajay Kumar, Ambrish Mithal, and Nikhil Tandon
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1000-day challenge ,diabetes mellitus ,glycated hemoglobin ,impact india ,india diabetes care index ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
India has the second largest population with diabetes mellitus in the world. Long-term, uncontrolled diabetes is associated with increased microvascular and macrovascular (commonly cardiovascular) complications and death. The large burden of uncontrolled diabetes in India could be because of lack of treatment adherence, limited access to laboratory testing, lack of physical activity, and poor dietary habits. This creates a compelling need for a greater involvement of healthcare professionals (HCPs) in improving societal awareness and regular monitoring of glycemic control, which is limited in patient outreach programs. IMPACT India, launched in November 2018, is a diabetes control program with a three-pronged approach aimed at creating an impact at the level of HCPs, society, and individuals living with diabetes. The India Diabetes Care Index (iDCI®), a quarterly aggregate index of glycated hemoglobin, fasting plasma glucose (FPG), and postprandial plasma glucose (PPG), forms the backbone of IMPACT India. The program uses iDCI® to evaluate glycemic control at periodic intervals, sensitize HCPs about the glycemic control status, and optimize diabetes care by escalating pharmacotherapy including insulin whenever required. Societal awareness will be created by social media to achieve actionable awareness based on the iDCI® reports. At baseline (January 2018 to June 2018), the database (2.39 million) revealed an average glycated hemoglobin of 8.56%, FPG of 172 mg/dL, and PPG of 253 mg/dL. Also, 74% of the patients had HbA1c >7% and FPG >130 mg/dL and >83% of the patients had PPG >160 mg/dL. The IMPACT India program aims to positively impact diabetes care in India by achieving at least 1% glycated hemoglobin reduction in 1000 days.
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- 2021
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10. Access to information and use of IT as a dimension of preparedness for hospital practice among Malaysian housemen
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Abd Manaf, N. H., primary, Omar, A., additional, Adeyemi, A. A., additional, Mohd, D., additional, Ismail, I., additional, and Abdul Hamid, Z., additional
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- 2013
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11. Lifestyle, Quality of Life and Physical Activity Barriers among Female Students of Kerman University of Medical Sciences, Iran
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Mohammad Pourranjbar and Abdul Hamid Zeytoonli
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physical activity ,barriers ,quality of life ,lifestyle ,female students ,university ,Immunologic diseases. Allergy ,RC581-607 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Physical activity level among women is unsatisfactory worldwide due to the increasing use of computer games, internet and some social barriers. This study aimed to investigate the lifestyle, quality of life and physical activity barriers among female students of Kerman University of Medical Sciences, Iran. Methods: According to Morgan's table, 374 students were selected as research sample in 2017. They were provided with three questionnaires including 68 items (5-point Likert scale) to assess their physical activity barrier, quality of life and lifestyle (LSQ). Data were analyzed through SPSS 20 and using One-Sample t-test, ANOVA, Tukey and Spearman tests. Results: All students were aware of the positive effects of physical activity on the quality of life, but their average level of participation in physical activity per week was lower than the average rate. There was a significant relationship between physical activity and quality of life (p < 0.005). Personal issues, development of internet and technology, advertisements, social issues, lack of facilities for physical activity, as well as financial and economic issues were respectively the most important barriers of participation in physical activities among studied students. Conclusions: Elimination of physical activity barriers and designing health education programs in order to promote regular physical activity and increase physical self-esteem of participants are recommended. Providing more facilities and safe environments would have positive effects in improving health and quality of lifestyle in female students.
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- 2019
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12. Preparation and Properties of Polyvinyl Alcohol/Banana Frond Flour Biodegradable Film.
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Mat Suki, F. M., Ismail, H., and Abdul Hamid, Z. A.
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POLYVINYL alcohol ,BIODEGRADABLE plastics ,TENSILE strength ,COST control ,MOLDING of plastics - Abstract
A series of biodegradable films, based on polyvinyl alcohol (PVA) and banana frond flour (BFF) was prepared using a solution-casting method. BFF was added to PVA in order to improve biodegradability and reduce cost. The blended films were evaluated for their tensile properties, water absorption, water vapour transmissibility (WVT) and degradation under natural weathering. Tensile strength and elongation at the break of PVA/BFF films were lower than unfilled PVA film, but the tensile modulus was higher. Water absorption and WVT of the blended films increased upon increasing the BFF content. The presence of BFF influences degradation and causes a reduction of the tensile properties of the PVA/BFF blended films. [ABSTRACT FROM AUTHOR]
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- 2014
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13. Diabetes and COVID-19: A Review
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Arjun Baidya, Santosh Kumar Singh, Sarita Bajaj, Abdul Hamid Zargar, Parminder Singh, Sambit Das, and Anand Shankar
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Corona virus ,COVID-19 ,diabetes mellitus ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Coronavirus Disease 2019 (COVID-19) is an emerging disease and since its first identification in Wuhan, China, in December 2019, there has been a rapid increase in cases and deaths across the world. COVID-19 has been shown to have an immense impact in infected persons with diabetes, worsening their outcome, especially in elderly, smokers, obese, those having CVD, CKD, poor glycemic control and long duration of diabetes. In this review we summarize the current understanding of `the impact of COVID-19 on diabetes and discusses the pathophysiological mechanisms and management of diabetes and its complication in this scenario.
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- 2020
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14. Polymorphic analysis of leptin promoter in obese/diabetic subjects in Kashmiri population
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Rubiya Dar, Shabhat Rasool, Ajaz Ahmad Waza, Gazalla Ayoub, Meenu Qureshi, Abdul Hamid Zargar, Iftikhar Bashir, Tariq Jan, and Khurshid Iqbal Andrabi
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diabetes ,leptin ,leptin receptor ,obesity ,single-nucleotide polymorphisms ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background: The role of common variants in leptin promoter has already been established to play a major role in obesity and diabetes in humans. The study was accordingly focused on leptin promoter variants and their potential association with diabetes and obesity in ethnic population from Kashmir, India. Methods: Allele frequencies of 620 Kashmiri subjects with diabetes (200), obese subjects (200), and ethnically matched healthy controls (200) were tested for the Hardy–Weinberg disequilibrium. Among 200 obese subjects, a total of 50 persons were with diabetes. The genotype and allele frequencies were evaluated using the Chi-square or Fisher's exact tests. Results: Sequence analysis revealed two reported variations i.e., rs72563764C>T and rs7799039G>A in promoter region. Both variants show homozygous as well as heterozygous genotypes. These variations indicated significant difference with respect to allelic and genotypic frequencies in all groups i.e., persons with diabetes, obese, and obese persons with diabetes (P < 0.05). We also analyzed the association of these variations with biochemical characteristics and found significant association of rs72563764C>T with triglycerides (TG) in obese patients and fasting plasma glucose (FPG) and random blood sugar (RBS) in obese/persons with diabetes. Also rs7799039G>A showed association with postprandial plasma sugar (PPPS) in obese patients and FPG and resting plasma glucose (RPG) in obese persons with diabetes. Conclusions: Our results are suggestive of the association of leptin promoter gene variations i.e., rs72563764C>T and rs7799039G>A with both diabetes and obesity.
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- 2019
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15. Diabetes insipidus: The other diabetes
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Sanjay Kalra, Abdul Hamid Zargar, Sunil M Jain, Bipin Sethi, Subhankar Chowdhury, Awadhesh Kumar Singh, Nihal Thomas, A G Unnikrishnan, Piya Ballani Thakkar, and Harshad Malve
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Antidiuretic hormone ,desmopressin ,polydipsia ,polyuria ,vasopressin ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Diabetes insipidus (DI) is a hereditary or acquired condition which disrupts normal life of persons with the condition; disruption is due to increased thirst and passing of large volumes of urine, even at night. A systematic search of literature for DI was carried out using the PubMed database for the purpose of this review. Central DI due to impaired secretion of arginine vasopressin (AVP) could result from traumatic brain injury, surgery, or tumors whereas nephrogenic DI due to failure of the kidney to respond to AVP is usually inherited. The earliest treatment was posterior pituitary extracts containing vasopressin and oxytocin. The synthetic analog of vasopressin, desmopressin has several benefi ts over vasopressin. Desmopressin was initially available as intranasal preparation, but now the oral tablet and melt formulations have gained significance, with benefits such as ease of administration and stability at room temperature. Other molecules used for treatment include chlorpropamide, carbamazepine, thiazide diuretics, indapamide, clofibrate, indomethacin, and amiloride. However, desmopressin remains the most widely used drug for the treatment of DI. This review covers the physiology of water balance, causes of DI and various treatment modalities available, with a special focus on desmopressin.
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- 2016
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16. Efficacy and safety of Vitamin D supplementation during pregnancy: A randomized trial of two different levels of dosing on maternal and neonatal Vitamin D outcome
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Shahnaz Ahmad Mir, Shariq Rashid Masoodi, Shafia Shafi, Iqra Hameed, Maqsood Ahmad Dar, Mir Iftikhar Bashir, Arshad Iqbal Wani, Zaffar Amin Shah, Shameema Parveen, Abdul Hamid Zargar, and Parviz Ahmad Shah
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Dose ,efficacy ,pregnancy ,Vitamin D ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction: Pregnant women represent a typical group susceptible to dietary and mineral deficiencies. This study was sought to assess the efficacy and safety of various doses of 25-hydroxyvitamin D (25[OH]D) supplementation during pregnancy and ratify the inadequacy of the recommended daily allowance for Vitamin D in vulnerable groups. Materials and Methods: A total of 100 pregnant women were included in this open-label, parallel group, prospective, randomized, and controlled trial. Study subjects were assigned to four treatment groups: Group 1 (n = 26), 1000 IU of Vitamin D daily; Group 2 (n = 21), 30,000 IU of Vitamin D monthly; Group 3 (n = 27), 2000 IU of Vitamin D daily; and Group 4 (n = 26), 60,000 IU Vitamin D monthly. Group 1 and 2 were further analyzed together as Group 1K (1000 IU daily and 30,000 IU monthly), and Group 3 and 4 as Group 2K (2000 IU daily and 60,000 IU monthly). The analysis was done on an intention to treat basis. Results: A total of 87 patients completed the study; 21 in Group 1, 25 in Group 2, 18 in Group 3, and 23 in Group 4. The levels of 25(OH)D at baseline ranged from 1.3 to 58.0 with a mean of 24.2 ± 15.1 ng/ml. Postsupplementation, 25(OH)D levels ranged from 11.5 to 70.3 with a mean of 40.2 ± 12.2 ng/ml. The postsupplementation levels of 25(OH)D were higher in Group 2K (42.86 ± 12.83) than in Group 1K (36.96 ± 10.56) with P value of 0.023. Conclusion: We concluded that Vitamin D supplementation with 2000 IU/day or 60,000 IU/month is very effective and safe in achieving Vitamin D sufficiency in pregnant women.
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- 2016
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17. Optimal TCSC Allocation via Chaotic Immune Symbiotic Organisms Search for Voltage Profile Improvement
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Mohamad Zamani Mohamad Khairuzzaman, Musirin Ismail, Suliman Saiful Izwan, Syed Mustaffa Sharifah Azma, Mohd Ali Nur Zahirah, Mansor Mohd Helmi, and Abdul Hamid Zulkiffli
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Environmental sciences ,GE1-350 - Abstract
As the load demand in a power system increases, power system operators struggle to maintain the power system to be operated within its acceptable limits. If no mitigation actions are taken, a power system may suffer from voltage collapse, which in turn leads to blackout. Flexible AC Transmission System (FACTS) devices can be employed to help improve the voltage profile of the power system. This paper presents the implementation of Chaotic Immune Symbiotic Organism Search (CISOS) optimization technique to solve optimal Thyristor Controlled Series Compensator (TCSC) in a power system for voltage profile improvement. Validation process are conducted on IEEE 26-bus RTS resulting in the capability of CISOS in solving the allocation problem with a better voltage profile. Comparative studies conducted with respect to Particle Swarm Optimization (PSO) and Evolutionary Programming (EP) has revealed the superiority of CISOS over PSO and EP in solving the optimal allocation problem by producing optimal solution with a better voltage profile. The results and information obtained from this study can help power system operator in terms of optimal compensation in power system as well as improving the operation of a power system.
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- 2020
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18. Tight glycemic control and cardiovascular effects in type 2 diabetic patients
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Latha Subramanya Moodahadu, Ruchi Dhall, Abdul Hamid Zarġar, Sudhakar Banġera, Lalitha Ramani, and Ramesh Katipally
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Diabetes mellitus ,gliptins ,non pharmacological measures ,oral hypoglycemic agents ,tight glycemic control ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Diabetes Mellitus (DM) with poor glycemic control is one of the leading causes for cardiovascular mortality in diabetic patients. Tight glycemic control with glycosylated haemoglobin of
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- 2014
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19. Protocol of an observational study to evaluate diabetic nephropathy through detection of microalbuminuria in Indian patients
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Gokulnath, Manisha Sahay, Sanjay Kalra, Vijay Vishwanathan, Abdul Hamid Zargar, Pradeep G Talwalkar, Subhash Kumar Wangnoo, Debasish Maji, G Vijay Kumar, Ramesh Kumar Sharma, Deodatta Chafekar, Brij Mohan, Ganapathi Bantwal, Anil Bansali, and Jasmeet Singh Sahni
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Diabetic nephropathy ,dipstick test ,health policy ,India ,microalbuminuria ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Aim: To assess the prevalence of persistent microalbuminuria (MAU), its clinical correlates by dip stick method, its predictive value for potential kidney disease and the utility of this test as objective cue for health care seeking behavior in adult Indian patients with type 2 diabetes mellitus. Materials and Methods: Approximately 400,000 patients shall be enrolled in this multicentric, cross sectional study. Patients meeting eligibility criteria shall be screened for MAU through urine dipstick test using random daytime single spot urine specimen. Result shall be expressed either positive or negative based on the presence or absence of albumin in the urine and will be correlated with the corresponding random blood glucose. Height, weight, waist circumference and blood pressure shall be assessed. There will be three visits with a minimum interval of 28 days between two visits, to be completed within 180 days, and at least two of three urine tests measured in this period must show elevated albumin levels to diagnose MAU. Conclusion: Detection of MAU through the dipstick method is postulated to be a rapid, reliable test for early detection of diabetic nephropathy, which, in turn will help the physician to plan treatment strategy. Further, it will help to identify the disease burden on the individual and society, and may serve as an objective cue for improved health care seeking behavior, as well as a catalyst for health policy change.
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- 2013
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20. South Asian Consensus Guideline: Use of insulin in diabetes during Ramadan
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Md Faruque Pathan, Rakesh Kumar Sahay, Abdul Hamid Zargar, Syed Abbas Raza, A K Azad Khan, Mohammed Ashraf Ganie, Nazrul Islam Siddiqui, Firoz Amin, Osama Ishtiaq, and Sanjay Kalra
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Aspart ,basal insulin ,detemir ,glargine ,lispro ,premixed insulin ,regular insulin ,type 1 diabetes ,type 2 diabetes ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
A person with diabetes mellitus (DM) has every right to perform the ritual of fasting during Ramadan. In daily practice we come across both type 1 and type 2 DM who wish to fast. This Consensus Statement describes the pre-Ramadan assessment, planning, prescription, management, and monitoring of patients on insulin, who wish to fast.
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- 2012
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21. Hyperglycemic emergencies in Indian patients with diabetes mellitus on pilgrimage to Amarnathji yatra
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Mohd Ashraf Ganie, Satish Koul, Hilal A Razvi, Bashir Ahmed Laway, and Abdul Hamid Zargar
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Amarnath shrine ,diabetic ketoacidosis ,high altitude climbing ,starvation ,type 2 diabetes mellitus ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background: Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) represent two distinct metabolic derangements manifested by insulin deficiency and severe hyperglycemia, with estimated mortality rates of 2.5-9%. In patients with type 2 diabetes mellitus (DM) controlled by diet or oral agents, DKA does not occur unless there is significant severe stress such as severe sepsis, major surgery, trauma, etc. We observed many such emergencies occurring in pilgrims. Objective: We analyzed the data of 13 patients with DM admitted in our endocrine department with hyperglycemic emergencies during 2 years of the annual pilgrimage (yatra) to Amarnathji. Materials and Methods: We reviewed and analyzed the case records of 13 yatris with DM who were referred and admitted in our hospital with hyperglycemic emergencies during the yatra season (July-August) of 2006 and 2007. Results: Eleven of 13 had DKA and 1 each had HHS and hypoglycemia. After initial clinical assessment and blood sampling for blood counts, electrolytes, blood gases, urinalysis, chest radiography, and electrocardiography, these cases were managed with standard protocol published by American Diabetes Association (ADA) for the management of DKA and HHS. Average blood glucose was 466 mg/dl and nine subjects had moderate to severe ketonuria. All the cases, except one, were in stable condition at the time of discharge. Conclusion: High altitude, strenuous exertion of going uphill, withdrawal of insulin or oral hypoglycemic drugs, starvation, sepsis, and alcohol intake were recorded as predisposing factors. Therefore, there is an immense need for institution of a special health education program to all the yatris before taking the endeavor.
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- 2012
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22. Role of oral hypoglycemic agents in the management of type 2 diabetes mellitus during Ramadan
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Mir Iftikhar Bashir, Md Faruque Pathan, Syed Abbas Raza, Jamal Ahmad, A K Azad Khan, Osama Ishtiaq, Rakesh K Sahay, Aisha Sheikh, and Abdul Hamid Zargar
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Gliptins ,hypoglycemia ,insulin sensitizers ,Ramadan fasting ,sulfonylureas ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
It is obligatory for all adult Muslims to observe fast during the holy month of Ramadan, but sick individuals including those with diabetes mellitus are exempted from the duty of fasting. Specific medical advice must be provided to individual patients concerning the potential risks they must accept if they decide to fast. Any alteration in medications deemed necessary to provide an effective and safe antidiabetic regimen should be instituted well before the start of Ramadan. Diet-controlled patients and those well controlled on insulin sensitizers have low risk of hypoglycemia and may safely fast with some modification in the timing of the doses. Newer generation sulfonylureas (gliclazide MR and glimepiride) have reasonable safety profile during Ramadan fasting and are economical options for a large number of diabetics worldwide, especially in the developing countries; older, long acting sulfonylureas like glibenclamide and chlorpropamide should be avoided during fasting. Oral DPP-IV inhibitors are important substitutes to sulfonylureas for patients with diabetes mellitus during fasting owing to their glucose-dependent mechanism of action, efficacy, and tolerability. This group of drugs causes a moderate A1c reduction, are weight neutral, and have a very low risk of hypoglycemia. Short-acting insulin secretagogues are an option in the subset of fasting diabetic patients who have predominantly post-prandial hyperglycemia.
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- 2012
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23. Pattern of urinary albumin excretion in normotensive young and adolescent Indian women with polycystic ovary syndrome
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Mohd Ashraf Ganie, Khalid Jamal Farooqui, Mohd Ashraf Bhat, Mohammad Muzzafar Mir, Zaffar Amin Shah, Syed Douhath, Syed Hussain Mir, Fouzia Rashid, Shazia Naqshi, Mohd Ibrahim Masoodi, S A Zargar, and Abdul Hamid Zargar
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Endothelial dysfunction ,microalbuminuria ,polycystic ovary syndrome ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Objective: Polycystic ovarian syndrome (PCOS) is a clinically heterogeneous endocrine disorder affecting up to 4-8% of women of reproductive age. The aim of this study was to evaluate the presence of microalbuminuria in women with PCOS and study its correlation with the various metabolic, clinical, and hormonal parameters. Materials and Methods: A cross-sectional study involving 69 PCOS women was carried out in a tertiary care center hospital. The diagnosis of PCOS was made according to the Rotterdam criteria. Blood samples were collected in the follicular phase of the menstrual cycle and analyzed for fasting luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), 17-hydroxyprogesterone (17-OHP), total testosterone (T), glucose, insulin, and lipid profile. Urinary albumin was measured in the first void spot urine sample. Results: The mean age of the subjects was 22.0 ± 4.1 years and 21.8 ± 4.7 years in normoalbuminuric and microalbuminuric groups, respectively. Urinary albumin excretion (UAE) varied from 5 mg/l to 100 mg/ml, with a median of 5 mg/l. Microalbuminuria was observed in 17/69 (24.6%) of subjects. The mean UAE was 3.65 ± 4.44 mg/l in the normoalbuminuria group versus 45.29 ± 22.74 mg/l in the microalbuminuria group. Upon univariate analysis, hip circumference, diastolic blood pressure, and fasting blood glucose showed significant correlations with urinary albumin concentration (r = 0.264, 0.264, and 0.551, respectively; P = 0.028, 0.029, and 0.000, respectively). No association between UAE and the usual cardiovascular risk factors could be found upon regression analysis. Conclusion: About 24.6% of women with PCOS showed presence of microalbuminuria in the first void spot urine sample. Screening for the presence of microalbuminuria can help in early identification of a subset of PCOS women with a high risk for future CVD, who can be subjected to preventive strategies at the earliest. However, further studies are needed before recommending routine use of UAE in PCOS cases for the detection of CVD risk.
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- 2012
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24. Selective preservation of anterior pituitary functions in patients with Sheehan′s syndrome
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Bashir Ahmad Laway, Shahnaz Ahmad Mir, Tariq Gojwari, Tariq Rashid Shah, and Abdul Hamid Zargar
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Corticotrophs ,empty sella ,postpartum hemorrhage ,regular cycles ,Sheehan′s syndrome ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background: Sheehan′s syndrome manifests as hypopituitarism following a child birth usually preceded by postpartum hemorrhage. The symptoms range from vague feelings of ill health to symptoms of a full blown panhypopituitarism. A large series of such patients is not described in the literature. Materials and Methods: We present the details of ten women with partial Sheehan′s syndrome. They presented with post-partum hemorrhage and lactation failure. Results: After delivery, seven out of ten patients had regular menstrual cycles indicating preservation of gonadotroph function. Lactotroph, thyrotroph, and somatotroph failure were present in all and corticotrophs preservation was documented in four out of ten patients. The hypophysial magnetic resonance imaging (MRI) confirmed empty sella in all. Conclusion: lactotroph, somatotroph and thyrotroph failure are common in patients with Sheehan′s syndrome. In addition to known preservation of gonadotroph axis, corticotroph axis may be preserved in some of these patients arguing against the universal treatment of these patients with glucocorticoids.
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- 2011
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25. Crafting a conference: Endocrine Society of India Annual Conference Bhopal 2013
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Sushil Jindal, Sanjay Kalra, Sachin Chittawar, and Abdul Hamid Zargar
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Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2013
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26. Guidelines regarding management of adrenal insufficiency in the Holy month of Ramadan
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Sheelu S Siddiqi, S K Singh, Shakeel Ahamad Khan, Osama Ishtiaq, Md. Faruque Pathan, Syed Abbas Raza, A K Azad Khan, Abdul Hamid Zargar, and Ganapathy Bantwal
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Adrenal insufficiency ,diet ,drug of choice ,physical activity ,Ramadan ,sick-day management ,warning sign ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Adrenal insufficiency is a life-threatening event, so it is recommended for patients with known adrenal insufficiency to be properly educated regarding sick-day management. In the month of Ramadan, people refrain from eating and drinking during daylight hours. It is very important for patients with adrenal insufficiency, who wish to keep a fast, to be well aware of the disease, the suitable drug to be used for that particular period, warning signs, sick-day management, physical activity, and dietary limits. This article describes guidelines for the sick-day management of patients with adrenal insufficiency, in the month of Ramadan.
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- 2012
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27. Fasting guidelines for diabetic children and adolescents
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Kiswhar Azad, Fauzia Mohsin, Abdul Hamid Zargar, Bedowra Zabeen, Jamal Ahmad, Syed Abbas Raza, Samin Tayyeb, Sarita Bajaj, Osama Ishtiaq, and Sanjay Kalra
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Adolescent ,Ramadan ,type 1 diabetes ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Fasting during the month of Ramadan, the ninth month of Islamic lunar calendar, is obligatory for all healthy adult and adolescent Muslims from the age of 12 years. Fasting starts from early dawn (Sohur/Sehri) till sunset (Iftar). During this period one has to abstain from eating and drinking. Islam has allowed many categories of people to be exempted from fasting, for example, young children, travelers, the sick, the elderly, pregnant, and lactating women. According to expert opinion, patients with type 1 diabetes (type 1 DM) who fast during Ramadan are at a very high risk to develop adverse events. However, some experienced physicians are of the opinion that fasting during Ramadan is safe for type 1 DM patients, including adolescents and older children, with good glycemic control who do regular self-monitoring and are under close professional supervision. The strategies to ensure safety of type 1 diabetic adolescents who are planning to fast include the following: Ramadan-focused medical education, pre-Ramadan medical assessment, following a healthy diet and physical activity pattern, modification in insulin regimen, and blood glucose monitoring as advised by the physician.
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- 2012
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28. South Asian Consensus Guideline: Use of GLP-1 analogue therapy in diabetes during Ramadan
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Md Faruque Pathan, Rakesh Kumar Sahay, Abdul Hamid Zargar, Syed Abbas Raza, A K Azad Khan, Nazrul Islam Siddiqui, Firoz Amin, and Sanjay Kalra
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DPP4 ,exanetide ,hypoglycemia ,insulin ,Liraglutide ,oral antidiabetic drugs ,type 2 diabetes ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Ramadan is a lunar based month, during which Muslims across the world observe the ritual fast. This provides a challenge not only to the diabetic patient who wishes to observe the fast but also to the health care professional managing his diabetes. The challenge is to use therapies which are effective in maintaining good glycemic control and at the same time have a low propensity to cause hypoglycemia during the several hours of no calorie intake. The GLP-1 analogues are unique agents which are effective in providing glycemic reduction with a very low risk of hypoglycemia and hence find an important place in the management of diabetes during Ramadan. This Consensus Statement describes the pre-Ramadan assessment, planning, prescription and management and monitoring of patients who are on GLP-1 analogues, with or without other antidiabetic therapies.
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- 2012
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29. Training in endocrinology: The Indian perspective
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Chitra Selvan, Sujoy Ghosh, Sanjay Kalra, and Abdul Hamid Zargar
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Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2013
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30. Rising rural body-mass index is the main driver of the global obesity epidemic in adults
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Bixby, Honor, Bentham, James, Zhou, Bin, Di Cesare, Mariachiara, Paciorek, Christopher J., Bennett, James E., Taddei, Cristina, Stevens, Gretchen A., Rodriguez-Martinez, Andrea, Carrillo-Larco, Rodrigo M., Khang, Young-Ho, Soric, Maroje, Gregg, Edward W., Miranda, J. Jaime, Bhutta, Zulfiqar A., Savin, Stefan, Sophiea, Marisa K., Iurilli, Maria L. C., Solomon, Bethlehem D., Cowan, Melanie J., Riley, Leanne M., Danaei, Goodarz, Bovet, Pascal, Chirita-Emandi, Adela, Hambleton, Ian R., Hayes, Alison J., Ikeda, Nayu, Kengne, Andre P., Laxmaiah, Avula, Li, Yanping, McGarvey, Stephen T., Mostafa, Aya, Neovius, Martin, Starc, Gregor, Zainuddin, Ahmad A., Abarca-Gomez, Leandra, Abdeen, Ziad A., Abdrakhmanova, Shynar, Ghaffar, Suhaila Abdul, Hamid, Zargar Abdul, Garba, Jamila Abubakar, Abu-Rmeileh, Niveen M., Acosta-Cazares, Benjamin, Adams, Robert J., Aekplakorn, Wichai, Afsana, Kaosar, Agdeppa, Imelda A., Aguilar-Salinas, Carlos A., Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Naser, Ahmadvand, Alireza, Ahrens, Wolfgang, Ajlouni, Kamel, AlBuhairan, Fadia, AlDhukair, Shahla, Al-Hazzaa, Hazzaa M., Ali, Mohamed M., Ali, Osman, Alkerwi, Ala'a, Al-Othman, Amani Rashed, Al-Raddadi, Rajaa, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N., Amouyel, Philippe, Amuzu, Antoinette, Bo, Lars, Anderssen, Sigmund A., Angquist, Lars H., Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Aounallah-Skhiri, Hajer, Araujo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E., Arlappa, Nimmathota, Aryal, Krishna K., Aspelund, Thor, Assah, Felix K., Assuncao, Maria Cecilia F., Aung, May Soe, Auvinen, Juha, Avdicova, Maria, Azevedo, Ana, Azizi, Fereidoun, Azmin, Mehrdad, Babu, Bontha V., Baharudin, Azli, Bahijri, Suhad, Baker, Jennifer L., Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, Jose R., Barbagallo, Carlo M., Barcelo, Alberto, Barkat, Amina, Barros, Aluisio J. D., Barros, Mauro V. G., Bata, Iqbal, Batieha, Anwar M., Batista, Rosangela L., Battakova, Zhamilya, Batyrbek, Assembekov, Baur, Louise A., Beaglehole, Robert, Bel-Serrat, Silvia, Ben Romdhane, Habiba, Benedics, Judith, Benet, Mikhail, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Bettiol, Heloisa, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K., Bi, Hongsheng, Bi, Yufang, Biehl, Anna, Lele, Elysee Claude Bika, Bikbov, Mukharram, Bista, Bihungum, Bjelica, Dusko J., Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B., Bjorkelund, Cecilia, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M., Boehm, Bernhard O., Boeing, Heiner, Boggia, Jose G., Boissonnet, Carlos P., Bonaccio, Marialaura, Bongard, Vanina, Bopp, Matthias, Borchini, Rossana, Borghs, Herman, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn C. E., Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Breda, Joao, Brenner, Hermann, Brewster, Lizzy M., Brian, Garry R., Brinduse, Lacramioara, Bruno, Graziella, Bueno-de-Mesquita, H. Bas, Bugge, Anna, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, Cabrera de Leon, Antonio, Cacciottolo, Joseph, Cai, Hui, Cama, Tilema, Cameron, Christine, Camolas, Jose, Can, Gamze, Can, Gunay, Candido, Ana Paula C., Canete, Felicia, Capanzana, Mario V., Capuano, Eduardo, Capuano, Vincenzo, Cardoso, Viviane C., Carlsson, Axel C., Carmuega, Esteban, Carvalho, Maria J., Casanueva, Felipe F., Casas, Juan-Pablo, Caserta, Carmelo A., Celikcan, Ertugrul, Censi, Laura, Cesar, Juraci A., Chamukuttan, Snehalatha, Chan, Angelique W., Chan, Queenie, Chaturvedi, Himanshu K., Chaturvedi, Nishi, Rahim, Norsyamlina Che Abdul, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheng, Yiling J., Chetrit, Angela, Chikova-Iscener, Ekaterina, Chiolero, Arnaud, Chiou, Shu-Ti, Chirlaque, Maria-Dolores, Cho, Belong, Cho, Yumi, Christensen, Kaare, Christofaro, Diego G., Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Claessens, Frank, Clarke, Janine, Clays, Els, Concin, Hans, Confortin, Susana C., Cooper, Cyrus, Coppinger, Tara C., Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L., Crampin, Amelia C., Crujeiras, Ana B., Cruz, Juan J., Cucu, Alexandra, Cui, Liufu, Dallongeville, Jean, Damasceno, Albertino, Damsgaard, Camilla T., Dankner, Rachel, Dantoft, Thomas M., D'Arrigo, Graziella, Dasgupta, Parasmani, Dastgiri, Saeed, Dauchet, Luc, Davletov, Kairat, De Backer, Guy, De Bacquer, Dirk, De Curtis, Amalia, de Gaetano, Giovanni, De Henauw, Stefaan, de Oliveira, Paula Duarte, De Ridder, Karin, de Rooij, Susanne R., De Smedt, Delphine, Deepa, Mohan, Deev, Alexander D., Dehghan, Abbas, Delisle, Helene, Delpeuch, Francis, Dennison, Elaine, Deschamps, Valerie, Dhana, Klodian, Dhimal, Meghnath, Di Castelnuovo, Augusto F., Dias-da-Costa, Juvenal Soares, Diaz, Alejandro, Dika, Zivka, Djalalinia, Shirin, Do, Ha T. P., Dobson, Annette J., Donati, Maria Benedetta, Donfrancesco, Chiara, Donoso, Silvana P., Doering, Angela, Dorobantu, Maria, Dorosty, Ahmad Reza, d'Orsi, Eleonora, Doua, Kouamelan, Drygas, Wojciech, Duan, Jia Li, Duante, Charmaine A., Duda, Rosemary B., Duleva, Vesselka, Dulskiene, Virginija, Dumith, Samuel C., Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Eddie, Ricky, Egbagbe, Eruke E., Eggertsen, Robert, Eiben, Gabriele, Ekelund, Ulf, El Ati, Jalila, Eldemire-Shearer, Denise, Eliasen, Marie, Elliott, Paul, Engle-Stone, Reina, Erasmus, Rajiv T., Erem, Cihangir, Eriksen, Louise, Eriksson, Johan G., Escobedo-de la Pena, Jorge, Evans, Alun, Faeh, David, Fall, Caroline H., Sant'Angelo, Victoria Farrugia, Farzadfar, Farshad, Fattahi, Mohammad R., Felix-Redondo, Francisco J., Ferguson, Trevor S., Fernandes, Romulo A., Fernandez-Berges, Daniel, Ferrante, Daniel, Ferrari, Marika, Ferreccio, Catterina, Ferrer, Eldridge, Ferrieres, Jean, Fijalkowska, Anna, Fink, Gunther, Fischer, Krista, Flores, Eric Monterubio, Foeger, Bernhard, Foo, Leng Huat, Forslund, Ann-Sofie, Forsner, Maria, Fouad, Heba M., Francis, Damian K., Franco, Maria do Carmo, Franco, Oscar H., Frontera-Juan, Guillem, Fuchs, Flavio D., Fuchs, Sandra C., Fujita, Yuki, Furusawa, Takuro, Gaciong, Zbigniew, Gafencu, Mihai, Galeone, Daniela, Galvano, Fabio, Gao, Jingli, Garcia-de-la-Hera, Manoli, Gareta, Dickman, Garnett, Sarah P., Gaspoz, Jean-Michel, Gasull, Magda, Gates, Louise, Gazzinelli, Andrea, Geiger, Harald, Geleijnse, Johanna M., Ghanbari, Ali, Ghasemi, Erfan, Ghasemian, Anoosheh, Gheorghe-Fronea, Oana-Florentina, Giampaoli, Simona, Gianfagna, Francesco, Gill, Tiffany K., Giovannelli, Jonathan, Gironella, Glen, Giwercman, Aleksander, Godos, Justyna, Gogen, Sibel, Goldsmith, Rebecca A., Goltzman, David, Goncalves, Helen, Gonzalez, Angel R., Gonzalez-Chica, David A., Gonzalez-Gross, Marcela, Gonzalez-Leon, Margot, Gonzalez-Rivas, Juan P., Gonzalez-Villalpando, Maria-Elena, Gottrand, Frederic, Graca, Antonio Pedro, Graff-Iversen, Sidsel, Grafnetter, Dusan, Grajda, Aneta, Grammatikopoulou, Maria G., Gregor, Ronald D., Grodzicki, Tomasz, Grontved, Anders, Grosso, Giuseppe, Gruden, Gabriella, Gu, Dongfeng, Gualdi-Russo, Emanuela, Gudmundsson, Elias F., Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L., Gulliford, Martin C., Gunnlaugsdottir, Johanna, Gunter, Marc, Guo, Xiuhua, Guo, Yin, Gupta, Prakash C., Gupta, Rajeev, Gureje, Oye, Gurzkowska, Beata, Gutierrez, Laura, Gutzwiller, Felix, Hadaegh, Farzad, Hadjigeorgiou, Charalambos A., Haghshenas, Rosa, Halkjaer, Jytte, Hardy, Rebecca, Kumar, Rachakulla Hari, Hassapidou, Maria, Hata, Jun, Haugsgjerd, Teresa, He, Jiang, He, Yuna, Heidinger-Felso, Regina, Heinen, Mirjam, Hejgaard, Tatjana, Hendriks, Marleen Elisabeth, Henriques, Ana, Hernandez Cadena, Leticia, Herrala, Sauli, Herrera, Victor M., Herter-Aeberli, Isabelle, Heshmat, Ramin, Hill, Allan G., Ho, Sai Yin, Ho, Suzanne C., Hobbs, Michael, Hofman, Albert, Hopman, Wilma M., Horimoto, Andrea R. V. R., Hormiga, Claudia M., Horta, Bernardo L., Houti, Leila, Howitt, Christina, Htay, Thein Thein, Htet, Aung Soe, Htike, Maung Maung Than, Hu, Yonghua, Huerta, Jose Maria, Huhtaniemi, Ilpo Tapani, Petrescu, Constanta Huidumac, Huisman, Martijn, Husseini, Abdullatif, Chinh Nguyen Huu, Huybrechts, Inge, Hwalla, Nahla, Hyska, Jolanda, Iacoviello, Licia, Ibarluzea, Jesus M., Ibrahim, Mohsen M., Wong, Norazizah Ibrahim, Ikram, M. Arfan, Irazola, Vilma E., Ishida, Takafumi, Islam, Muhammad, Ismail, Aziz al-Safi, Ivkovic, Vanja, Iwasaki, Masanori, Jaaskelainen, Tuija, Jackson, Rod T., Jacobs, Jeremy M., Jaddou, Hashem, Jafar, Tazeen, James, Kenneth, Jamil, Kazi M., Jamrozik, Konrad, Janszky, Imre, Janus, Edward, Jarani, Juel, Jarvelin, Marjo-Riitta, Jasienska, Grazyna, Jelakovic, Ana, Jelakovic, Bojan, Jennings, Garry, Jeong, Seung-Lyeal, Jiang, Chao Qiang, Jimenez, Ramon O., Joffres, Michel, Johansson, Mattias, Jokelainen, Jari J., Jonas, Jost B., Jorgensen, Torben, Joshi, Pradeep, Jovic, Dragana P., Jozwiak, Jacek, Juolevi, Anne, Jurak, Gregor, Juresa, Vesna, Kaaks, Rudolf, Kafatos, Anthony, Kajantie, Eero O., Kalter-Leibovici, Ofra, Kamaruddin, Nor Azmi, Kameli, Yves, Kapantais, Efthymios, Karki, Khem B., Kasaeian, Amir, Katibeh, Marzieh, Katz, Joanne, Katzmarzyk, Peter T., Kauhanen, Jussi, Kaur, Prabhdeep, Kavousi, Maryam, Kazakbaeva, Gyulli, Keil, Ulrich, Keinan-Boker, Lital, Keinanen-Kiukaanniemi, Sirkka, Kelishadi, Roya, Kelleher, Cecily, Kemper, Han C. G., Kerimkulova, Alina, Kersting, Mathilde, Key, Timothy, Khader, Yousef Saleh, Khalili, Davood, Khateeb, Mohammad, Khaw, Kay-Tee, Kheiri, Bahareh, Khosravi, Alireza, Khouw, Ilse M. S. L., Kiechl, Stefan, Kiechl-Kohlendorfer, Ursula, Killewo, Japhet, Kim, Jeongseon, Kim, Yeon-Yong, Klimont, Jeannette, Klumbiene, Jurate, Knoflach, Michael, Koirala, Bhawesh, Kolle, Elin, Kolsteren, Patrick, Koenig, Jurgen, Korpelainen, Raija, Korrovits, Paul, Korzycka, Magdalena, Koskinen, Seppo, Kouda, Katsuyasu, Kovacs, Viktoria A., Kowlessur, Sudhir, Koziel, Slawomir, Kratzer, Wolfgang, Kriemler, Susi, Kristensen, Peter Lund, Krokstad, Steinar, Kromhout, Daan, Kruger, Herculina S., Kubinova, Ruzena, Kuciene, Renata, Kuh, Diana, Kujala, Urho M., Kujundzic, Enisa, Kulaga, Zbigniew, Kumar, R. Krishna, Kunesova, Marie, Kurjata, Pawel, Kusuma, Yadlapalli S., Kuulasmaa, Kari, Kyobutungi, Catherine, Quang Ngoc La, Laamiri, Fatima Zahra, Laatikainen, Tiina, Lachat, Carl, Laid, Youcef, Tai Hing Lam, Morovic, Maja Lang, Lanska, Vera, Lappas, Georg, Larijani, Bagher, Latt, Tint Swe, Laugsand, Lars E., Lauria, Laura, Lazo-Porras, Maria, Khanh Le Nguyen Bao, Le Port, Agnes, Le, Tuyen D., Lee, Jeannette, Lee, Jeonghee, Lee, Paul H., Lehtimaki, Terho, Lemogoum, Daniel, Levitt, Naomi S., Lilly, Christa L., Lim, Wei-Yen, Lima-Costa, M. Fernanda, Lin, Hsien-Ho, Lin, Xu, Lind, Lars, Linneberg, Allan, Lissner, Lauren, Litwin, Mieczyslaw, Liu, Jing, Loit, Helle-Mai, Lopes, Luis, Lopez, Tania, Lopez-Garcia, Esther, Lorbeer, Roberto, Lotufo, Paulo A., Lozano, Jose Eugenio, Luksiene, Dalia, Lundqvist, Annamari, Lundqvist, Robert, Lunet, Nuno, Lytsy, Per, Ma, Guansheng, Ma, Jun, Machado-Coelho, George L. L., Machado-Rodrigues, Aristides M., Machi, Suka, Maggi, Stefania, Magliano, Dianna J., Magriplis, Emmanuella, Maire, Bernard, Majer, Marjeta, Makdisse, Marcia, Malekzadeh, Fatemeh, Malekzadeh, Reza, Malhotra, Rahul, Malyutina, Sofia, Maniego, Lynell V., Manios, Yannis, Mann, Jim I., Manzato, Enzo, Margozzini, Paula, Markaki, Anastasia, Markey, Oonagh, Ioannidou, Eliza Markidou, Marques, Larissa Pruner, Marques-Vidal, Pedro, Marrugat, Jaume, Martin, Rosemarie, Martin-Prevel, Yves, Martorell, Reynaldo, Martos, Eva, Marventano, Stefano, Masoodi, Shariq R., Mathiesen, Ellisiv B., Mathur, Prashant, Matijasevich, Alicia, Matsha, Tandi E., Mazur, Artur, Mbanya, Jean Claude N., McFarlane, Shelly R., Mckee, Martin, McLachlan, Stela, McLean, Rachael M., McLean, Scott B., McNulty, Breige A., Yusof, Safiah Md, Mediene-Benchekor, Sounnia, Medzioniene, Jurate, Mehdipour, Parinaz, Meirhaeghe, Aline, Meisfjord, Jorgen, Meisinger, Christa, Menezes, Ana Maria B., Menon, Geetha R., Mensink, Gert B. 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A, Plans-Rubió P, Poh BK, Pohlabeln H, Pop RM, Popovic SR, Porta M, Portegies MLP, Posch G, Poulimeneas D, Pouraram H, Pourshams A, Poustchi H, Pradeepa R, Price AJ, Price JF, Puder JJ, Pudule I, Puhakka SE, Puiu M, Punab M, Qasrawi RF, Qorbani M, Quoc Bao T, Radhika MS, Radic I, Radisauskas R, Rahman M, Raitakari O, Raj M, Rajkumar H, Rakhmatulloev S, Ramachandra Rao S, Ramachandran A, Ramke J, Ramos E, Ramos R, Rampal L, Rampal S, Rao KM, Rascon-Pacheco RA, Rasmussen M, Redon J, Reganit PFM, Regecová V, Revilla L, Ribas-Barba L, Ribeiro R, Riboli E, Rigo F, Rinaldo N, Rinke de Wit TF, Rito A, Ritti-Dias RM, Rivera JA, Robitaille C, Rodrigues D, Rodríguez-Artalejo F, Rodriguez-Perez MC, Rodríguez-Villamizar LA, Rojas-Martinez R, Rojroongwasinkul N, Romaguera D, Rosengren A, Rouse I, Roy JGR, Rubinstein A, Rühli FJ, Ruidavets J-B, Ruiz Moreno E, Ruiz-Betancourt BS, Russo P, Rust P, Rutkowski M, Sabanayagam C, Sachdev HS, Safiri S, Saidi O, Salanave B, Salazar-Martinez E, Salmerón D, 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H, Zapata ME, Zaw KK, Zdrojewski T, Zeljkovic Vrkic T, Zeng Y, Zhao D, Zhao W, Zheng W, Zheng Y, Zholdin B, Zhou M, Zhu D, Zhussupov B, Zimmermann E, Zuñiga Cisneros J, Ezzati M, Yiallouros, Panayiotis K. [0000-0002-8339-9285], APH - Societal Participation & Health, APH - Aging & Later Life, Epidemiology and Data Science, Public and occupational health, APH - Health Behaviors & Chronic Diseases, and APH - Personalized Medicine
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Male ,Rural Population ,obesity ,Obesity, body mass index ,Settore MED/09 - Medicina Interna ,Letter ,Urban Population ,Epidemiology ,[SDV]Life Sciences [q-bio] ,humanos ,body-mass index ,adolescente ,Geographic Mapping ,Sex Factor ,países desarrollados ,Rural Health ,purl.org/pe-repo/ocde/ford#3.03.09 [https] ,systematic analysis ,Body Mass Index ,países en desarrollo ,80 and over ,risk factors ,Age Factor ,physical-activity ,mediana edad ,mapeo geográfico ,Aged, 80 and over ,anciano ,purl.org/pe-repo/ocde/ford#3.02.18 [https] ,dieta ,Age Factors ,health ,adulto ,Middle Aged ,Multidisciplinary Sciences ,adulto joven ,[SDV] Life Sciences [q-bio] ,estado nutricional ,nutrition ,Science & Technology - Other Topics ,NUTRITION ,Female ,HEALTH ,pooled analysis ,Diet, Healthy ,worldwide trends ,Human ,Developed Countrie ,Adult ,Adolescent ,purl.org/pe-repo/ocde/ford#3.03.04 [https] ,FOOD SYSTEM ,Socio-culturale ,Nutritional Status ,URBAN ,Aged ,Developed Countries ,Developing Countries ,Humans ,Obesity ,Sex Factors ,Urban Health ,Young Adult ,POOLED ANALYSIS ,Developing Countrie ,MIDDLE-INCOME COUNTRIES ,SYSTEMATIC ANALYSIS ,Urban rural Obesity Body-Mass-Index ,obesidad ,Middle-income countries ,food system ,urban ,weight ,Healthy ,Science & Technology ,índice de masa corporal ,Diet ,PHYSICAL-ACTIVITY ,WORLDWIDE TRENDS ,Risk factors ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,WEIGHT - Abstract
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities(.)(1,2) This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity(3-6). Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017-and more than 80% in some low- and middle-income regions-was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing-and in some countries reversal-of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories., This study was funded by the Wellcome Trust. H.B. was supported by a Medical Research Council Doctoral Training Partnership Studentship, J.B. by a Royal Society Research Grant, and M.D.C. by an Academy of Medical Sciences Springboard Award. We thank L. Jaacks, B. Popkin, S. Sundberg and W. Willett for recommendations of relevant citations. The authors are responsible for the views expressed in this Letter and they do not necessarily represent the views, decisions, or policies of the institutions with which they are affiliated.
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- 2019
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31. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants
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A., Soric, Maroje, Jerome, Charles Sossa, Soumare, Aicha, Staessen, Jan A., Starc, Gregor, Stathopoulou, Maria G., Staub, Kaspar, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D., Stergiou, George S., Stessman, Jochanan, Stieber, Jutta, Stöckl, D., Stocks, Tanja, Stokwiszewski, Jakub, Stratton, Gareth, Strufaldi, Maria Wany, Sun, C. A., Sundstroem, Johan, Sung, Y. T., Sunyer, Jordi, Suriyawongpaisal, Paibul, Swinburn, Boyd A., Sy, Rody G., Szponar, Lucjan, Tai, E. Shyong, Tammesoo, Mari-Liis, Tamosiunas, Abdonas, Tang, Line, Tang, Xun, Tanser, Frank, Tao, Yong, Tarawneh, Mohammed Rasoul, Tarp, Jakob, Tarqui-Mamani, Carolina B., Taylor, Anne, Tchibindat, Felicite, Thijs, Lutgarde, Thuesen, Betina H., Tjonneland, Anne, Tolonen, Hanna K., Tolstrup, Janne S., Topbas, Murat, Topor-Madry, Roman, Torrent, Maties, Traissac, Pierre, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Trinh, Oanh T. 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Goya, Wareham, Nicholas, Weerasekera, Deepa, Whincup, Peter H., Widhalm, Kurt, Widyahening, Indah S., Wiecek, Andrzej, Wilks, Rainford J., Willeit, Johann, Wojtyniak, Bogdan, Wong, Jyh Eiin, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Frederick C., Wu, Jianfeng, Wu, Shou Ling, Xu, Haiquan, Xu, Liang, Yamborisut, Uruwan, Yan, Weili, Yang, Xiaoguang, Yardim, Nazan, Ye, Xingwang, Yiallouros, Panayiotis K., Yoshihara, Akihiro, You, Qi Sheng, Younger-Coleman, Novie O., Yusoff, Ahmad F., Zainuddin, Ahmad A., Zambon, Sabina, Zdrojewski, Tomasz, Zeng, Yi, Zhao, Dong, Zhao, Wenhua, Zheng, Yingfeng, Zhou, Maigeng, Zhu, Dan, Zimmermann, Esther, Cisneros, Julio Zuniga, NCD Risk Factor Collaboration (NCD-RisC), Di Cesare, M., Bentham, J., Stevens, G.A., Zhou, B., Danaei, G., Lu, Y., Bixby, H., Cowan, M.J., Riley, L.M., Hajifathalian, K., Fortunato, L., Taddei, C., Bennett, J.E., Ikeda, N., Khang, Y.H., Kyobutungi, C., Laxmaiah, A., Li, Y., Lin, H.H., Miranda, J.J., Mostafa, A., Turley, M.L., 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JR, Barbagallo CM, Barceló A, Barkat A, Barros MV, Bata I, Batieha AM, Batista RL, Baur LA, Beaglehole R, Romdhane HB, Benet M, Bernabe-Ortiz A, Bernotiene G, Bettiol H, Bhagyalaxmi A, Bharadwaj S, Bhargava SH, Bhatti Z, Bhutta ZA, Bi HS, Bi Y, Bjerregaard P, Bjertness E, Bjertness MB, Björkelund C, Blake M, Blokstra A, Bo S, Bobak M, Boddy LM, Boehm BO, Boeing H, Boissonnet CP, Bongard V, Bovet P, Braeckman L, Bragt MCE, Brajkovich I, Branca F, Breckenkamp J, Brenner H, Brewster LM, Brian GR, Bruno G, Bueno-de-Mesquita HB, Bugge A, Burns C, de León CA, Cacciottolo J, Cama T, Cameron C, Camolas J, Can G, Cândido APC, Capuano V, Cardoso VC, Carvalho MJ, Casanueva FF, Casas J-P, Caserta CA, Castetbon K, Chamukuttan S, Chan AW, Chan Q, Chaturvedi HK, Nishi Chaturvedi N, Chen C-J, Chen F, Chen H, Chen S, Chen Z, Cheng C-Y, Chetrit A, Chiolero A, Chiou S-T, Chirita-Emandi A, Cho Y, Kaare Christensen K, Chudek J, Renata Cifkova R, Claessens F, Clays E, Concin H, Cooper C, Cooper R, Coppinger TC, Costanzo C, Cottel D, Cowell C, Craig CL, Crujeiras AB, D'Arrigo G, d'Orsi E, Dallongeville J, Damasceno A, Damsgaard CT, Dankner R, Luc Dauchet L, De Backer G, De Bacquer D, de Gaetano G, De Henauw S, De Smedt D, Deepa M, Deev AD, Dehghan A, Delisle H, Delpeuch F, Dhana K, Di Castelnuovo AF, Dias-da-Costa JS, Diaz A, Djalalinia S, Do HTP, Dobson AJ, Donfrancesco C, Döring A, Doua K, Drygas W, Egbagbe EE, Eggertsen R, Ekelund U, El Ati J, Elliott P, Engle-Stone R, Erasmus RT, Erem C, Eriksen L, Escobedo-de la Peña J, Evans A, Faeh D, Fall CH, Farshad Farzadfar F, Felix-Redondo FJ, Ferguson TS, Fernández-Bergés D, Ferrante D, Ferrari M, Ferreccio C, Ferrieres J, Finn JD, Fischer K, Monterubio Flores E, Föger B, Foo LH, Forslund A-S, Fortmann SP, Fouad HM, Francis DK, Franco MdC, Franco OH, Guillermo Frontera G, Fuchs FH, Fuchs SC, Fujita Y, Furusawa T, Gaciong Z, Gafencu M, Gareta D, Garnett SP, Gaspoz J-M, GasulL M, Gates L, Geleijnse JM, Ghasemian A, Giampaoli S, GianfagnA F, Giovannelli J, Giwercman A, Goldsmith RA, Gonzalez Gross M, González Rivas JP, Gorbea MB, Gottrand F, Graff-Iversen S, Grafnetter D, Grajda A, Grammatikopoulou MG, Gregor RD, Grodzicki T, Grøntved A, Gruden G, Grujic V, Gu D, Guan OP, Gudnason V, Guerrero R, Guessous I, Guimaraes AL, Gulliford MC, Gunnlaugsdottir J, Guo XK, Guo Y, Gupta PC, Gureje O, Gurzkowska B, Gutierrez L, Gutzwiller F, Halkjær J, Hardy R, Kumar RH, Hayes AJ, He J, Hendriks ME, Hernandez Cadena L, Heshmat R, Hihtaniemi IP, Sai SY, Ho SC, Hobbs M, Hofman A, Hormiga CM, Horta BH, Houti L, Htay TT, Htet AS, Htike MMT, Hu Y, Hussieni HS, Huu CN, Huybrechts I, Hwalla N, Iacoviello L, Iannone AG, Ibrahim MM, Ikram MA, Irazola VE, Islam M, Iwasaki M, Jackson RT, Jacobs JM, Tazeen Jafar T, Jamil KM, Jamrozi K, Jasienska G, Jiang CQ, Joffres M, Johansson M, Jonas JB, Jørgensen T, Joshi P, Juolevi A, Jurak G, Vesna Jureša V, Kaaks R, Kafatos A, Kalter-Leibovici O, Kapantais E, Kasaeian A, Katz J, Kaur P, Kavousi M, Keil U, Keinan Boker L, Kelishadi R, Kemper HHCG, Kengne AP, Kersting M, Key T, Khader YS, Khalili D, Khang Y-H, Kay-Tee H Khaw K-TH, Khouw LMSL, Kiechl S, Killewo J, Kim J, Kiyohara Y, Klimont J, Kolle E, Kolsteren P, Korrovits P, Koskinen S, Kouda K, Koziel S, Kratzer W, Krokstad S, Kromhout D, Kruger HS, Kula K, Kulaga Z, Kumar RK, Kusuma YS, Kuulasmaa K, Laamiri FZ, Laatikainen T, Lachat C, Laid Y, Lam TH, Landrove O, Lanska V, Lappas G, Laugsand LE, Nguyen Bao KL, Le TD, Leclercq C, Lee J, Jeonghee Lee J, Lehtimäki T, Lekhraj R, León-Muñoz LM, Lim W-Y, M Fernanda Lima-Costa MF, Lin H-H, Lin X, Linneberg A, Lissner L, Litwin M, Liu J, Lorbeer R, Lotufo PA, Lozano JE, Luksiene D, Lundqvist A, Lunet N, Lytsy P, Ma G, Machi S, Maggi S, Magliano DJ, Makdisse M, Malekzadeh R, Malhotra R, Mallikharjuna Rao K, Manios Y, Mann JI, Manzato E, Margozzini P, Markey O, Marques-Vidal P, Marrugat P, Martin-Prevel Y, Martorell R, Masoodi SR, Matsha TE, Mazur A, Mbanya JCN, McFarlane SR, McGarvey ST, McKee M, McLachlan S, McLean RM, McNulty BA, Md Yusof S, Mediene-Benchekor S, Meirhaeghe A, Meisinger A, Mendes LL, Menezes AMB, Mensink GBM, Meshram II, Metspalu A, Mi JM, Michaelsen KF, Miller JC, Miquel JF, Mišigoj-Duraković M, Mohamed MK, Mohammad K, Mohammadifard N, Mohan V, Mohd Yusoff MF, Molbo D, Møller NC, Molnár D, Mondo CK, Monterrubio EA, Monyeki KDK, Leila B Moreira LB, Morejon A, Moreno LA, Morgan K, Mortensen EL, Moschonis G, Mossakowska M, Mota J, Motlagh ME, Motta J, Mu TT, Muiesan ML, Müller-Nurasyid M, Murphy N, Mursu J, Murtagh EM, Musa KI, Musil V, Nagel G, Nakamura H, Námešná J, Nang EEK, Nangia VB, Nankap M, Narake S, Navarrete-Muñoz EM, Nenko I, Neovius M, Nervi F, Neuhauser HK, Nguyen ND, Ngoc Nguyen Q, Nieto-Martínez RE, Ning G, Ninomiya T, Nishtar S, Noale M, Norat T, Noto D, Al Nsour M, O'Reilly D, Ochoa-Avilés AM, Oh K, Olayan IH, Olinto MTA, Oltarzewski M, Omar MA, Onat A, Ordunez P, Ortiz AP, Osler M, Osmond C, Ostojic AM, Otero JA, Overvad K, Paccaud F, Padez C, Pajak A, Palli D, Palloni A, Palmieri L, Panda-Jonas S, Panza F, Parnell WR, Parsaeian M, Pednekar MS, Peeters PH, Peixoto SV, Pereira AC, Pérez CM, Peters A, Peykari N, Pham ST, Pigeot I, Pikhart H, Pilav A, Pilotto L, Pistelli F, Pitakaka F, Piwonska A, Piwonski J, Pedro Plans-Rubió P, Poh BK, Porta M, Portegies MLP, Poulimeneas D, Pradeepa R, Prashant M, Price JF, Puiu M, Punab M, Qasrawi RF, Qorbani M, Quoc Bao T, Radic I, Ricardas Radisauskas R, Rahman M, Raitakari O, Raj M, Ramachandra Rao S, Ramachandran A, Ramke J, Ramos R, Rampal S, Rasmussen F, Redon J, Reganit PFM, Robespierre Ribeiro R, Riboli E, Rigo F, Rinke de Wit TF, Ritti-Dias RM, Juan A Rivera JA, Robinson SM, Robitaille C, Rodríguez-Artalejo F, Rodriguez-Perez MdC, Rodríguez-Villamizar LA, Rojas-Martinez R, Rojroongwasinkul N, Romaguera D, Ronkainen K, Rosengren A, Rouse I, Rubinstein A, Rühli FJ, Rui O, Ruiz-Betancourt BS, Russo Horimoto ARV, Rutkowski M, Sabanayagam C, Sachdev HS, Saidi O, Salanave B, Salazar Martinez E, Salomaa V, Salonen JT, Salvetti M, Sánchez-Abanto J, Sandjaja A, Sans S, Santos DA, Santos O, dos Santos RN, Santos R, Sardinha LB, Sarrafzadegan N, Saum K-U, Savva SC, Scazufca M, Schaffrath Rosario A, Schargrodsky H, Schienkiewitz A, Schmidt IM, Schneider IJ, Schultsz C, Schutte AE, Sein AA, Sen A, Senbanjo IO, Sepanlou SG, Shalnova SA, Shaw JE, Shibuya K, Shin Y, Shiri R, Siantar R, Sibai AM, Silva AM, Simon M, Simons J, Simons LA, Sjostrom M, Slowikowska-Hilczer J, Slusarczyk P, Smeeth L, Smith MC, Snijder MB, So H-K, Sobngwi E, Söderberg S, Soekatri MYE, Solfrizzi V, Sonestedt E, Sørensen TIA, Sorić M, Sossa Jérome C, Soumare A, Staessen JA, Starc G, Stathopoulou MG, Staub K, Stavreski B, Steene-Johannessen J, Stehle P, Stein AD, Stergiou GS, Stessman J, Stieber J, Stöckl D, Stocks T, Stokwiszewski J, Stratton G, Strufaldi MW, Chien-An Sun C-A, Sundström J, Sung Y-T, Sunyer J, Suriyawongpaisal P, Swinburn BA, Sy RG, Szponar L, E Shyong Tai E, Tammesoo M-L, Tamosiunas A, Tang L, Tang X, Tanser F, Tao Y, Tarawneh M, Jakob Tarp J, Tarqui-Mamani CB, Taylor A, Félicité Tchibindat F, Thijs L, Thuesen BH, Tjonneland A, Tolonen HK, Janne S Tolstrup JS, Topbas M, Topór-Madry R, Torrent M, Traissac P, Trichopoulos D, Trinh OTH, Trivedi A, Tshepo L, Tulloch-Reid MK, Tuomainen T-P, Tuomilehto J, Tynelius P, Tzotzas T, Tzourio C, Ueda P, Ukoli FAM, Ulmer H, Unal B, Valdivia G, Susana Va S, Valvi D, van der Schouw YT, Van Herck K, Van Minh H, van Valkengoed IGM, Vanderschueren D, Vanuzzo D, Vatten L, Vega T, Velasquez-Melendez G, Veronesi G, Verschuren WMM, Viegi G, Viet L, Viikari-Juntura E, Vineis P, Vioque P, Virtanen JK, Visvikis-Siest S, Viswanathan B, Vollenweider P, Voutilainen S, Vrijheid M, Wade AN, Wagner A, Walton J, Wan Mohamud WN, Wang M-D, Wang Q, Wang YX, Wannamethee SG, Wareham N, Deepa Weerasekera D, Whincup PH, Widhalm K, Widyahening IS, Wiecek A, Wilks RJ, Willeit J, Wojtyniak B, Wong, Wong TY, Woo J, Woodward M, Wu FC, JianFeng Wu JF, Wu SL, Xu H, Xu L, Yamborisut U, Yan W, Yang X, Yardim N, Ye X, Yiallouros PK, Yoshihara A, Qi Sheng You QS, Younger-Coleman NO, Yusoff AF, Ahmad A Zainuddin AA, Zambon S, Zdrojewski T, Zeng Y, Zhao D, Zhao W, Zheng Y, Zhou M, Zhu D, Zimmermann E, Zuñiga Cisneros J, General Internal Medicine, AII - Amsterdam institute for Infection and Immunity, Public and occupational health, Global Health, and APH - Amsterdam Public Health
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Male ,Obesidad ,CHILDREN ,Salud ,Review ,países desarrollados ,Global Health ,Body Mass Index ,Body mass index, population study ,0302 clinical medicine ,Models ,Factores de riesgo cardiovascular ,Medicine ,body mass index ,underweight ,overweight ,obesity ,Young adult ,Human Nutrition & Health ,education.field_of_study ,Humane Voeding & Gezondheid ,General Medicine ,ASSOCIATION ,11 Medical And Health Sciences ,adulto ,predicción ,adulto joven ,CARDIOVASCULAR-DISEASE ,thinness/epidemiology ,NONCOMMUNICABLE DISEASES ,NCD Risk Factor Collaboration (NCD-RisC) ,Enfermedades cardiovasculares ,Developed country ,teorema de Bayes ,Medical sciences ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,Thinness ,Humans ,education ,Developing Countries ,obesidad ,VLAG ,Science & Technology ,Models, Statistical ,CAUSE-SPECIFIC MORTALITY ,Bayes Theorem ,medicine.disease ,QP ,Obesity ,adult body-mass ,Indice de masa corporal (IMC) ,RISK-FACTORS ,Adolescent ,Adult ,Developed Countries ,Female ,Forecasting ,Obesity/epidemiology ,Prevalence ,Thinness/epidemiology ,Young Adult ,RA ,Body mass index ,Demography ,Meta-Analysis ,Gerontology ,Settore MED/09 - Medicina Interna ,Nutrition and Disease ,humanos ,adolescente ,Overweight ,países en desarrollo ,Voeding en Ziekte ,Medicine and Health Sciences ,Global health ,030212 general & internal medicine ,Non-U.S. Gov't ,Medicine (all) ,Research Support, Non-U.S. Gov't ,prevalencia ,Public Health, Global Health, Social Medicine and Epidemiology ,Statistical ,Underweight ,medicine.symptom ,pooled analysis ,Life Sciences & Biomedicine ,obesity/*epidemiology ,Population ,030209 endocrinology & metabolism ,Research Support ,Medicine, General & Internal ,EPIDEMIC ,General & Internal Medicine ,Journal Article ,Life Science ,ddc:610 ,Obesidad morbida ,OBESITY PREVENTION ,OVERWEIGHT ,business.industry ,índice de masa corporal ,COHORTS ,purl.org/pe-repo/ocde/ford#3.02.00 [https] ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,Ciencias socio biomédicas ,business ,delgadez - Abstract
Copyright © NCD Risk Factor Collaboration. Open Access article distributed under the terms of CC BY., Background: Underweight and severe and morbid obesity are associated with highly elevated risks of adverse health outcomes. We estimated trends in mean body-mass index (BMI), which characterises its population distribution, and in the prevalences of a complete set of BMI categories for adults in all countries. Methods: We analysed, with use of a consistent protocol, population-based studies that had measured height and weight in adults aged 18 years and older. We applied a Bayesian hierarchical model to these data to estimate trends from 1975 to 2014 in mean BMI and in the prevalences of BMI categories (, Wellcome Trust, Grand Challenges Canada
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- 2016
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32. The role of selected flavonoids from bajakah tampala ( Spatholobus littoralis Hassk.) stem on cosmetic properties: A review.
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Novalia Rahmawati Sianipar R, Suryanegara L, Fatriasari W, Tangke Arung E, Wijaya Kusuma I, Setiati Achmadi S, Izyan Wan Azelee N, and Ain Abdul Hamid Z
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Cosmetics made from natural ingredients are increasingly popular because they contain bioactive compounds which can provide many health benefits, more environmentally friendly and sustainable. The health benefits obtained from natural-based ingredients include anti-aging, photoprotective, antioxidant, and anti-inflammatory. This article reviewed the potential of selected flavonoids from bajakah tampala ( Spatholobus littoralis Hassk.) as the native plant in Indonesia. We present in silico, in vitro, in vivo, and clinical research data on the use of selected flavonoids that have been reported in other extracts., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors.)
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- 2023
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33. The Role of PKC-MAPK Signalling Pathways in the Development of Hyperglycemia-Induced Cardiovascular Complications.
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Jubaidi FF, Zainalabidin S, Taib IS, Abdul Hamid Z, Mohamad Anuar NN, Jalil J, Mohd Nor NA, and Budin SB
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- Enzyme Activation, Humans, MAP Kinase Signaling System, Mitogen-Activated Protein Kinases metabolism, p38 Mitogen-Activated Protein Kinases metabolism, Diabetes Complications complications, Diabetes Mellitus, Hyperglycemia complications
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Cardiovascular disease is the most common cause of death among diabetic patients worldwide. Hence, cardiovascular wellbeing in diabetic patients requires utmost importance in disease management. Recent studies have demonstrated that protein kinase C activation plays a vital role in the development of cardiovascular complications via its activation of mitogen-activated protein kinase (MAPK) cascades, also known as PKC-MAPK pathways. In fact, persistent hyperglycaemia in diabetic conditions contribute to preserved PKC activation mediated by excessive production of diacylglycerol (DAG) and oxidative stress. PKC-MAPK pathways are involved in several cellular responses, including enhancing oxidative stress and activating signalling pathways that lead to uncontrolled cardiac and vascular remodelling and their subsequent dysfunction. In this review, we discuss the recent discovery on the role of PKC-MAPK pathways, the mechanisms involved in the development and progression of diabetic cardiovascular complications, and their potential as therapeutic targets for cardiovascular management in diabetic patients.
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- 2022
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34. Fallen lung sign in a traumatic partial bronchial tear: A case report.
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Sayuti KA, Wan Ahmed WA, Abdul Hamid Z, and Mazlan MZ
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The fallen lung sign describes the lung collapse at the dependent region away from the hilum. It is usually a specific sign for complete bronchial tear. We present a case of a young patient post mechanical ventilation for a traumatic head injury with unexpected CT thorax findings of fallen lung secondary to a partial bronchial tear. The patient was managed conservatively with specific ventilator strategy and successfully discharged home. Partial bronchial tear with fallen sign is a very rare cases reported., (© 2022 The Authors.)
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- 2022
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35. Onyx in Brain Arteriovenous Malformation Embolisation.
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Hashim H, Muda AS, Abdul Aziz A, and Abdul Hamid Z
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Introduction: Embolisation has long been used as an adjunct to surgical resection in the treatment of brain arteriovenous malformation (bAVM). The most commonly used embolic material, n-butylcyanoacrylate glue, requires experience and skill to handle its quick and unpredictable flow and polymerisation. A new liquid embolic agent, ethylene vinyl alcohol copolymer (Onyx), is less adhesive and polymerises slowly, which provides better control for radiologists performing embolisation., Objective: To report our experience in embolisation using Onyx alone or in combination with histoacryl for bAVM embolisation in our tertiary referral centre., Methods: We retrospectively reviewed the anatomy, technical conditions, complications and clinical outcome of all bAVM patients embolised at our centre using Onyx alone or in combination with n-butylcyanoacrylate glue., Results: Between 2010 and 2013, 13 patients [6 (46.2%) male; 7 (53.8%) female; aged, 14-57 years] were included, and a total of 31 embolisations were performed. Clinical presentation included hemorrhage [9 (69.2%)], seizures [2 (15.4%)], and headache [2 (15.4%)]. Most AVMs were located in the brain hemispheres [12 (92.3%)] and measured <3 cm [7 (53.8%]. Complete occlusion of the AVM was obtained in 2 (15.4%) patients; 11 (84.6%) patients had partial occlusion [6 (54.5%) had <50% nidus occlusion]. Complications occurred in four procedures involving 3 patients (morbidity, 23.1%). This resulted in the death of 1 patient (mortality, 7.7%) and complete recovery with no disability in 2 patients., Conclusion: The total nidal occlusion achieved herein is comparable to other similar studies. Our morbidity and mortality were higher compared to other studies which may be attributed to the small number of patients. More data is being collected which may better reflect on our experience.
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- 2016
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36. The association of nuclear abnormalities in exfoliated buccal epithelial cells with the health status of different agricultural activities farmers in Peninsular Malaysia.
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Abdul Hamid Z, Mohd Zulkifly MF, Hamid A, Lubis SH, Mohammad N, Ishak I, Mohd Saat NZ, Othman HF, Ghazali AR, Mohd Rafaai MJ, Mohd Noor MR, and Rajab NF
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Background: Pesticide exposure possesses risk of genotoxicity to humans, particularly farmers. Despite accumulating evidences linking genotoxicity to pesticide exposure, epidemiological studies to address pesticide toxicity in occupationally exposed farmers in Malaysia remain underreported. Thus, this study was aimed to determine the presence of nuclear abnormalities through the assessment of micronucleus (MN) and binucleus (BNu) frequencies in exfoliated buccal epithelial cells from farmers who were exposed to pesticides. A cross-sectional study of farmers among different agricultural activities farmers in Bachok and Pasir Puteh, Kelantan, North East of Peninsular Malaysia was done to evaluate the presence of nuclear abnormalities and its correlation with their health status and farming activities., Results: Analysis of buccal cells revealed that the frequency of MN was significantly higher (p < 0.05) in farmers as compared to controls. In contrast, no significant difference (p > 0.05) was observed for BNu frequency in between groups. Correlation analysis showed that apart from a significant (p < 0.05) and positive correlation between the duration of fertilizers exposure and frequencies of MN (r = 0.42, P = 0.001) and BNu (r = 0.37, P = 0.02), no other correlation of various confounding factors on the formation of MN and BNu were observed., Conclusion: In conclusion, pesticide and fertilizers exposure may contribute to the promotion of nuclear anomalies among Malaysian farmers who are engaged in mixed plantation activities. Further assessment of larger populations is important to address and overcome the potential risk of pesticide-induced genotoxicity.
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- 2016
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37. Lineage-related cytotoxicity and clonogenic profile of 1,4-benzoquinone-exposed hematopoietic stem and progenitor cells.
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Chow PW, Abdul Hamid Z, Chan KM, Inayat-Hussain SH, and Rajab NF
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- Animals, Antigens, Ly metabolism, Apoptosis drug effects, Biomarkers metabolism, CD11b Antigen metabolism, Cells, Cultured, Colony-Forming Units Assay, Dose-Response Relationship, Drug, Flow Cytometry, Hematopoietic Stem Cells metabolism, Hematopoietic Stem Cells pathology, Immunophenotyping, Leukocyte Common Antigens metabolism, Male, Membrane Proteins metabolism, Mice, Mice, Inbred ICR, Phenotype, Stem Cell Niche, Benzoquinones toxicity, Cell Lineage, Cell Proliferation drug effects, Hematopoietic Stem Cells drug effects
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Hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) are sensitive targets for benzene-induced hematotoxicity and leukemogenesis. The impact of benzene exposure on the complex microenvironment of HSCs and HPCs remains elusive. This study aims to investigate the mechanism linking benzene exposure to targeting HSCs and HPCs using phenotypic and clonogenic analyses. Mouse bone marrow (BM) cells were exposed ex vivo to the benzene metabolite, 1,4-benzoquinone (1,4-BQ), for 24h. Expression of cellular surface antigens for HSC (Sca-1), myeloid (Gr-1, CD11b), and lymphoid (CD45, CD3e) populations were confirmed by flow cytometry. The clonogenicity of cells was studied using the colony-forming unit (CFU) assay for multilineage (CFU-GM and CFU-GEMM) and single-lineage (CFU-E, BFU-E, CFU-G, and CFU-M) progenitors. 1,4-BQ demonstrated concentration-dependent cytotoxicity in mouse BM cells. The percentage of apoptotic cells increased (p < 0.05) following 1,4-BQ exposure. Exposure to 1,4-BQ showed no significant effect on CD3e(+) cells but reduced the total counts of Sca-1(+), CD11b(+), Gr-1(+), and CD45(+) cells at 7 and 12 μM (p < 0.05). Furthermore, the CFU assay showed reduced (p < 0.05) clonogenicity in 1,4-BQ-treated cells. 1,4-BQ induced CFU-dependent cytotoxicity by significantly inhibiting colony growth for CFU-E, BFU-E, CFU-G, and CFU-M starting at a low concentration of exposure (5μM); whereas for the CFU-GM and CFU-GEMM, the inhibition of colony growth was remarkable only at 7 and 12μM of 1,4-BQ, respectively. Taken together, 1,4-BQ caused lineage-related cytotoxicity in mouse HPCs, demonstrating greater toxicity in single-lineage progenitors than in those of multi-lineage., (Copyright © 2014 Elsevier Inc. All rights reserved.)
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- 2015
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38. The role of Hibiscus sabdariffa L. (Roselle) in maintenance of ex vivo murine bone marrow-derived hematopoietic stem cells.
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Abdul Hamid Z, Lin Lin WH, Abdalla BJ, Bee Yuen O, Latif ES, Mohamed J, Rajab NF, Paik Wah C, Wak Harto MK, and Budin SB
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- Animals, Bone Marrow Cells drug effects, Bone Marrow Cells physiology, Cell Survival drug effects, Cell Survival physiology, Male, Mice, Mice, Inbred ICR, Plant Extracts isolation & purification, Reactive Oxygen Species metabolism, Cell Culture Techniques methods, Hematopoietic Stem Cells drug effects, Hematopoietic Stem Cells physiology, Hibiscus, Plant Extracts pharmacology
- Abstract
Hematopoietic stem cells- (HSCs-) based therapy requires ex vivo expansion of HSCs prior to therapeutic use. However, ex vivo culture was reported to promote excessive production of reactive oxygen species (ROS), exposing HSCs to oxidative damage. Efforts to overcome this limitation include the use of antioxidants. In this study, the role of Hibiscus sabdariffa L. (Roselle) in maintenance of cultured murine bone marrow-derived HSCs was investigated. Aqueous extract of Roselle was added at varying concentrations (0-1000 ng/mL) for 24 hours to the freshly isolated murine bone marrow cells (BMCs) cultures. Effects of Roselle on cell viability, reactive oxygen species (ROS) production, glutathione (GSH) level, superoxide dismutase (SOD) activity, and DNA damage were investigated. Roselle enhanced the survival (P < 0.05) of BMCs at 500 and 1000 ng/mL, increased survival of Sca-1(+) cells (HSCs) at 500 ng/mL, and maintained HSCs phenotype as shown from nonremarkable changes of surface marker antigen (Sca-1) expression in all experimental groups. Roselle increased (P < 0.05) the GSH level and SOD activity but the level of reactive oxygen species (ROS) was unaffected. Moreover, Roselle showed significant cellular genoprotective potency against H2O2-induced DNA damage. Conclusively, Roselle shows novel property as potential supplement and genoprotectant against oxidative damage to cultured HSCs.
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- 2014
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39. Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats.
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Abdul Hamid Z, Budin SB, Wen Jie N, Hamid A, Husain K, and Mohamed J
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- Acetates, Acute Kidney Injury metabolism, Acute Kidney Injury pathology, Analgesics, Non-Narcotic toxicity, Animals, Antioxidants administration & dosage, Antioxidants pharmacology, Creatinine blood, Glutathione metabolism, Male, Malondialdehyde metabolism, Phytotherapy, Plant Extracts administration & dosage, Plant Extracts pharmacology, Rats, Rats, Sprague-Dawley, Acetaminophen toxicity, Acute Kidney Injury chemically induced, Acute Kidney Injury prevention & control, Oxidative Stress drug effects, Zingiberaceae
- Abstract
Paracetamol (PCM) overdose can cause nephrotoxicity with oxidative stress as one of the possible mechanisms mediating the event. In this study, the effects of ethyl acetate extract of Zingiber zerumbet rhizome [200 mg per kg of body weight (mg/kg) and 400 mg/kg] on PCM-induced nephrotoxicity were examined. Rats were divided into five groups containing 10 rats each. The control group received distilled water while other groups were treated with extract alone (400 mg/kg), PCM alone (750 mg/kg), 750 mg/kg PCM+200 mg/kg extract (PCM+200-extract), and 750 mg/kg PCM+400 mg/kg extract (PCM+400-extract), respectively, for seven consecutive days. The Z. zerumbet extract was given intraperitoneally concurrent with oral administration of PCM. Treatment with Z. zerumbet extract at doses of 200 and 400 mg/kg prevented the PCM-induced nephrotoxicity and oxidative impairments of the kidney, as evidenced by a significantly reduced (P<0.05) level of plasma creatinine, plasma and renal malondialdehyde (MDA), plasma protein carbonyl, and renal advanced oxidation protein product (AOPP). Furthermore, both doses were also able to induce a significant increment (P<0.05) of plasma and renal levels of glutathione (GSH) and plasma superoxide dismutase (SOD) activity. The nephroprotective effects of Z. zerumbet extract were confirmed by a reduced intensity of renal cellular damage, as evidenced by histological findings. Moreover, Z. zerumbet extract administered at 400 mg/kg was found to show greater protective effects than that at 200 mg/kg. In conclusion, ethyl acetate extract of Z. zerumbet rhizome has a protective role against PCM-induced nephrotoxicity and the process is probably mediated through its antioxidant properties.
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- 2012
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