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According to the data of 23 seismic stations of the Yakutia branch of GS RAS, the seismicity monitoring of the territory of the Republic of Sakha (Yakutia) was carried out for 2016–2017. During this period, more than 800 earthquakes with an energy class of KR≥7.1 (magnitude M≥1.7) were registered. This is somewhat more than in 2015 (N=567) and is due to the extension of the time interval of work up to 2 years. The epicenters were located in the zones of interaction between large lithospheric plates: the Eurasian and North American in the Northeastern and Arctic regions, as well as the Eurasian and Amur in the southern regions of Yakutia. The clusters of these events comprised two extended (Arctic-Asian and Baikal-Stanovoy) seismic belts. On the map of epicenters, these zones are displayed as a continuous strip of earthquakes from the Olekma River to the Sea of Okhotsk in the south and in the form of separate groups and clusters of earthquakes between the Laptev and Okhotsk Seas – in the northeast and in the Arctic. The highest seismic activity was noted in the Olekma area, the Stanovoy Ridge and the Aldan Highlands (Southern Yakutia) and the Chersky Ridge and Laptev Sea (in the North-East). Information on the manifestations of local seismicity in the Lena River Delta, where from August 2016 to December 2017 is given. 25 temporary field automatic stations under the joint Russian-German project "Seismicity and neotectonics of the Laptev Sea region" (SIOLA) in 2016–2018 operated. The first results of the distribution of Arctic earthquakes in the lower reaches of the Lena River in space, time, by depth and their connection with active tectonics are considered.

Актуальність. Згідно з керівництвом ACC/AHA короткостроковою метою лікування пацієнтів із нестабільною стенокардією є купірування ішемії і запобігання пов’язаним із нею явищам. Лікарські засоби (ЛЗ) метаболічної дії, що застосовуються в комплексній терапії з базисними кардіотропними засобами, дозволяють підвищити ефективність проведеного лікування в цілому. Одним із таких лікарських засобів є Тіотриазолін®. Мета дослідження: доказ більш високої ефективності терапії із застосуванням лікарського засобу Тіотриазолін® (розчин для ін’єкцій 25 мг/мл при курсовому застосуванні в складі комплексної терапії) у порівнянні з базисною терапією гострого коронарного синдрому (ГКС) без підйому сегмента ST. Матеріали та методи. Клінічне дослідження завершили 100 (в основній групі — 50, у контрольній групі — 50) пацієнтів із діагнозом «ОКС без підйому сегмента ST». Головним показником ефективності була комбінована змінна, що містила у собі оцінку наступних показників: збільшення ФВ за даними ехокардіографії більш ніж на 5 %; зменшення сумарної тривалості епізодів ішемії міокарда за добу за даними добового моніторування ЕКГ за методом Холтера не менше ніж на 10 %; зменшення кількості шлуночкових порушень ритму серця за добу за даними добового моніторування ЕКГ за методом Холтера не менше ніж на 10 %. Результати. Середня оцінка ефективності в основній групі склала 1,66 бала, а в контрольній — 0,74 бала (р

The paper addresses major achievements, current trends, and challenges in systems studies on energy development. Further evolution of the methodology for these studies in the context of "digitalization" will depend on the development of artificial intelligence tools. The scope of planned work and possible means for its implementation in the systems studies on the energy development in the future information society are investigated for various forms of its organization.

The structure, phase composition, static strength, and impact toughness of 10Kh3A steel of two heats with a nitrogen content higher than the solubility limit under standard conditions (from here on, overequilibrium content of 0.105 and 0.173% N at [C] + [N] = 0.26 and 0.3%, respectively) are studied. The steel is produced by electroslag remelting under nitrogen pressure (ESRP). The effect of this method on the inclusion cleanliness of steel in comparison with the electrode metal (grade 10 steel) is investigated. The porosity of the steel ingot is estimated in the initial state, after forging, and after hot isostatic pressing (HIP). Hot plastic deformation by forging decreases the volume fraction of pores from 0.07% (in the as-cast metal) to 0.013%. Additional HIP weakly affects the volume fraction of pores and does not change the pore size. The effects of the hot-rolling temperature and reduction (800, 850, 900–1050°C and e = 10, 20–90%, respectively), the quenching temperature, and the rate of subsequent cooling on the steel structure are studied. The conditions that provide the formation of a fine-grained martensitic structure in the steel with 0.173% N and allow a high level of hardness and tensile strength to 1800 MPa at satisfactory ductility to be achieved are revealed. The steel with 0.173% N is shown to have a better combination of strength and ductility than the steel with 0.105% N.

The article discusses the features of land management for agricultural organizations in conditions of radioactive contamination, and also suggests the most effective ways to reduce the negative impact of radioactive contamination on agricultural production.

The rapid rise in prices for charge materials used for smelting heat-resistant nickel alloy and steels leads to a significant rise in the cost of the final product. In order to curb the rise in prices for semi-finished products FSUE «VIAM» together with metallurgical plants of the industry, is carrying out work on testing and introducing new types of charge materials that can replace the currently used high-frequency materials. The article discussed the materials tested instead of those currently used in the smelting of steels and alloys containing chromium, tungsten and molybdenum, produced at domestic enterprises from domestic raw materials.

The statistical data on epilepsy, etiology and pathogenesis of the disease are given in the article. The main causes that affect the occurrence of epileptic seizures, and possible predictors that are sensitive to these causes (metabolic rate, blood flow velocity, change in electrical activity of the brain) are highlighted. The blood flow dynamics in the common carotid artery, which supplies the brain with oxygen and nutrients is proposed to be considered as one of the possible internal physiological parameters that are believed to be predictors of epileptic seizures.

In continuation of joint work of FSUE «VIAM» and IMET RAN named after Baikov, in the field of obtaining low-alloy steels with increased mechanical properties with a super-equilibrium nitrogen content, the mechanical properties, structure, and chemical composition of the obtained steel were studied. It is shown that steel 10KH3A with a super-equilibrium nitrogen content (up to 0,2) electroslag remelting under pressure DESHP-0,1 (FSUE «VIAM») provides a high level of properties (ultimate strength 1670 MPa) while maintaining high mechanical characteristics (elongation 10%, constriction 50%).

A nonlocal boundary-value problem for evolutional pseudodifferential equations in an infinite layer is considered in this paper. The notion of the partially parabolic boundary-value problem is introduced when a solving function decreases exponentially only by the part of space variables. This concept generalizes the concept of a parabolic boundary value problem, which was previously studied by one of the authors of this paper (A. A. Makarov). Necessary and sufficient conditions for the pseudodifferential operator symbol are obtained in which partially parabolic boundary-value problems exist. It turned out that the real part of the symbol of a pseudodifferential operator should increase unboundedly powerfully in some of the spatial variables. In this case, a specific type of boundary conditions is indicated, which depend on a pseudodifferential equation and are also pseudodifferential operators. It is shown that for solutions of partially parabolic boundary-value problems, smoothness in some of the spatial variables increases. The disturbed (excitated) pseudodifferential equation with a symbol which depends on space and temporal variables is also investigated. It has been found for partially parabolic boundary-value problems what pseudodifferential operators are possible to be disturbed in the way that the input equation of this boundary-value problem would remain correct in Sobolev-Slobodetsky spaces. It is also shown that although the properties of increasing the smoothness of solutions in part of the variables for partially parabolic boundary value problems are similar to the property of solutions of partially hypoelliptic equations introduced by L. H\"{o}rmander, these examples show that the partial parabolic boundary value problem does not follow from partial hipoellipticity; and vice versa - an example of a partially parabolic boundary value problem for a differential equation that is not partially hypoelliptic is given.

In this paper, we synthesize and analyze algorithms for detecting ultra-wideband quasi-radio signals against the background of Gaussian white noise and interference with linear frequency modulation under various a priori uncertainty conditions. Among the many UWB signals, a separate most promising class was identified – UWB QRS, whose structure is similar to narrowband radio signals, but the condition of relative narrowband for them is not fulfilled. A linear frequency modulation signal is considered as an interference when estimating the effectiveness of the detector of a UWB QRS. The selected interfering signal can be either intentional or unintentional, and is of the greatest interest to consider, since it has a similar structure to a useful signal and have the greatest destructive effect on correct reception. The dependence of the signal omission probability on the interference parameter and the interference-to-signal ratio is obtained, which allows to increase the detection efficiency by several orders of magnitude. A comparative analysis of the resistance to interfering signals of various detector circuits is performed. Recommendations are formulated to improve the efficiency of detectors operating in a complex interference environment, destabilizing information and technical influences, or attempts to unauthorized access to information.

One of the most crucial issues in the design of the ITER machine is the electromagnetic (EM) loads associated with eddy currents induced in the conducting structures during plasma disruptions. The ITER database contains tens of calculation scenarios for possible plasma disruption events. The duration of these scenarios is usually limited by the end of the plasma current quench when the toroidal plasma current decreases to zero. For further EM analysis, the currents in the poloidal field coils are conventionally assumed constant after the end of the current quench. Such approach is not good for estimation of electromagnetic loads acting on the tokamak components located outside vacuum vessel. A possible way to solve this problem is to employ pre-determined coil current variations over the entire period of observation including time interval after the current quench. This paper describes an approach to such electromagnetic calculations and comparative results for selected cases with/out an extended current-time specification.

The article deals with the treatment of ischemic heart disease. The attention is focused on the use as a part of combination therapy of drugs with proven metabolic action that normalize metabolic processes in myocardium, increase energy-saving and energy-synthesizing cell function, thus not affecting central hemodynamics, and thereby protect the cardiomyocytes. One of these drugs is Thiotriazolin. A meta-analysis of publications has been carried out on the use of Thiotriazolin (oral and parenteral) in patients with different forms of stable ischemic heart disease., Статья посвящена вопросам лечения ишемической болезни сердца. Акцентировано внимание на применении в составе комплексной терапии препаратов с доказанным метаболическим действием, которые нормализуют метаболические процессы в миокарде, повышают энергосберегающую и энергосинтезирующую функции клеток, при этом не влияя на центральную гемодинамику, и таким образом защищают кардиомиоциты. Одним из таких лекарственных средств является Тиотриазолин®. Проведен метаанализ публикаций, посвященных использованию Тиотриазолина® (внутрь и парентерально) у пациентов с разными формами стабильной ишемической болезни сердца.

The article deals with the treatment of acute coronary syndrome. We have considered the use of drugs with metabolic action as a part of the combination therapy, their feature is the ability to increase energy-saving and energy-synthesizing function of cells without affecting the central hemodynamics, and thus to protect cardiomyocytes. One of these drugs is Thiotriazolin. The article puts together the data from clinical studies on the efficacy and safety of Thiotriazolin (impact on the changes in echocardiography parameters, 24-hour Holter monitoring, 6-minute walk test)., Статья посвящена вопросам лечения острого коронарного синдрома. Рассматривается применение в комплексной терапии препаратов метаболического действия, особенностью которых является способность повышать энергосберегающую и энергосинтезирующую функции клеток, не влияя при этом на центральную гемодинамику, и таким образом защищать кардиомиоциты. Одним из таких лекарственных средств является Тиотриазолин®. В статье систематизированы данные клинических исследований эффективности и безопасности Тиотриазолина® (влияние на изменение параметров эхокардиографии, суточного мониторирования электрокардиографии по Холтеру, теста 6-минутной ходьбы)., Стаття присвячена питанням лікування гострого коронарного синдрому. Розглядається застосування в комплексній терапії препаратів метаболічної дії, особливістю яких є здатність підвищувати енергозберігаючу й енергосинтезуючу функції клітин, не впливаючи при цьому на центральну гемодинаміку, і таким чином захищати кардіоміоцити. Одним із таких лікарських засобів є Тіотриазолін®. У статті систематизовані дані клінічних досліджень ефективності й безпечності Тіотриазоліну® (вплив на зміни параметрів ехокардіографії, добового моніторування електрокардіографії за Холтером, тесту 6-хвилинної ходьби).

В статье продемонстрированы элиминационные характеристики физиологической системы почек на фоне применения метода водной нагрузки с форсированным диурезом в интенсивной терапии острого отравления таллием. Сделаны выводы о целесообразности и эффективности использования метода парентеральной водной нагрузки с форсированным диурезом в лечении острой таллиевой интоксикации.

В статье приведены результаты исследования токсикокинетики таллия в организме человека при острой таллиевой интоксикации. Исследованы концентрации таллия в сыворотке крови и моче, а также ее динамика в интервалах времени. Изучены показатели эндотоксикоза, который сопровождал острое отравление таллием. Сделаны выводы в отношении клинико-лабораторных параллелей и особенностей токсикокинетики таллиевой интоксикации.

The article considers the problems of teaching information technology to the adult population of Russia in accordance with the strategic direction of the country's development until 2025 - the digital economy, which requires improving the process of teaching information technology (IT), developing new pedagogical technologies and methods focused on modern conditions. Evaluation of developed methods of teaching IT and overcoming the psychological barrier in a large sample of the country's population for a long time shows their replicability and effectiveness.

In the classification of c-type cytochromes, the class III includes multihemic cytochromes c with low redox potential constituting the cytochrome c3 superfamily. Most of the cytochromes described have been isolated from sulfate or sulfur reducing bacteria. We report here the comparison between two multihemic cytochromes, the newly characterized 50 kDa cytochrome from Desulfuromonas acetoxidans and the cytochrome c7 from the same strain in order to contribute to understanding the relationships between members of this superfamily. The thermostability of these cytochromes was studied by circular dichroism (CD) and differential scanning calorimetry (DSC). The influence of the temperature on the redox potential was also investigated. The data clearly indicate the presence of two domains in 50 kDa cytochrome and a drastic loss of stability of cytochrome c7 in comparison to cytochrome c3. The results are discussed in the light of the structural properties of the cytochrome c3 superfamily and two sub-groups in this family are proposed.

The method of estimation of the geometry changes due to electronic excitations using resonance Raman intensities and the results of quantum chemical calculations was extended on the transition metal complexes with organic ligands. The local nature of the MLCT transitions greatly simplifies the method in that it is possible to work only with a fragment of the initial rather complicated complex ion. The method is applied to the study of the Ru(II) complexes with 2,2 ′ -bipyridine.

Compte rendu du travail de l'Academie des Sciences en matiere de perspectives energetiques d'ici l'an 2000: etude de la consommation d'energie, de la politique de maitrise de l'energie, de l'amelioration de la structure de production de l'energie et de l'influence du developpement de l'industrie energetique sur l'economie nationale

Considered in this paper is the use of "Ukrkosmos" services at deployment and operation of terrestrial TV broadcasting network in DVB-T standard.

The slow extraction of particles from the accelerator using parametric resonance of betatron oscillations is investigated. A special feature of the parametric resonance is the absence of separatrix on a phase plane. Therefore frequencies of betatron oscillations of the particles to be extracted at each revolution are to change abruptly. A value of this jump is need to be sufficient to transfer the frequencies of betatron oscillations of these particles inside the band of parametric resonance from the region outside and to ensure the increase of the oscillation amplitude in two revolutions, which is required to throw the particles in a gap of the extraction septum-magnet. It can be achieved through the energy losses of the particles, as ones passes through the thin target, and the use of sextupole lenses. Suggested techniques of the slow extraction can be applied for resonance of the higher order as well.

The perspective and development of a unified satellite system of information transfer for the Ukraine are presented. The features of a hybrid network of information transfer and the space segment are disclosed.

The results of the technical designing of a satellite distribution network of data support, created in Ukraine, are presented. Its technical feasibility and some features of its implementation are discussed.

The development aspects of a national network of monitoring stations using the NAVSTAR (USA) and GLONASS (RF) systems and, in the long term, GNSS are given on the basis of the projects ESA, EGNOS and GALILEO.

The thermostability of wild type Desulfovibrio vulgaris Hildenborough tetraheme cytochrome c3 and its H22M, H25M, H35M and H70M mutants was studied by circular dichroism technique in the far UV and Soret regions. It was shown that wild type cytochrome is extremely thermostable and retains structural and functional properties up to 110 degrees C. Mutations do not change overall secondary structure and local structure of the hemes vicinity. All mutants are much more unstable to heat denaturation than the wild type cytochrome. Point mutation (His/Met replacement) results in extraordinary 30-45 degrees C decrease in the protein thermostability depending on the mutation. We may conclude therefore that the heme region is important not only for the functional properties of the cytochrome but also for the overall protein thermostability.

The Storage-Accelerating Complex (SAC) of heavy ions is intended for the storage of ions up to Neon, their acceleration up to an energy of 300 MeV/n (A/Z=2), and physical experiment on an internal target with the electron cooling need at a high energy. The experiments can be performed both with narrow and wide beams on the targets. The stored current is about 10/sup 9/-10/sup 11/ particles, the luminosity is expected to be 10/sup 29/-10/sup 30/ cm/sup -2/ sec/sup -1/, the ion beam life-time - several tens of seconds. >

Two-step photodissociation of molecules is considered. Spatial radiation absorption is taken into account. Appropriate estimations and numerical calculations are presented. Conclusions are drawn about two-step photodissociation efficiency and quantum yield.

Binary mixtures of molecules with identical physical and chemical properties are considered. Infra-red laser radiation is assumed to excite vibrations of the chosen molecular component. Various possibilities for stimulation of selective chemical reactions are discussed. Appropriate estimations and numerical calculations of selectivity are presented.

Saved energy is viewed in our country as an energy resource of paramount importance, and energy-saving policy lies at the basis of the entire national energy program. There are two components to this policy. One component is energy saving as such, through the introduction of energy-saving technologies and advanced equipment to reduce losses of all kinds and thereby achieve higher efficiency in energy end use, and through changes in the production structure in favor of less energy intensive industries. Total annual savings achieved during the remaining years of this century will amount to 540–580 million tonnes of coal equivalent to (tce), or 1.6–1.7 × 1019 J. The other component of energy-saving policy is the substitution of nuclear energy, hydropower, and coal for high-cost hydrocarbons, through further electrification of thermal processes in industry, through large scale application of electric drives for gas pipeline compressors, and through exploitation of nuclear energy not only for the generation of electricity but also for heat supply. These measures are expected to yield annual savings of 400–500 million tce, or 1.2–1.5 × 1019 J. The foundation for the successful implementation of energy-saving policy is the state system of planning and implementing specialized but interconnected programs.