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Current theories of Autism Spectrum Disorder (ASD) suggest atypical use of context in ASD, but little is known about how these atypicalities influence speech perception. We examined the influence of contextual information (lexical, spectral, and temporal) on phoneme categorization of people with ASD and in typically developed (TD) people. Across three experiments, we found that people with ASD used all types of contextual information for disambiguating speech sounds to the same extent as TD; yet they exhibited a shallower identification curve when phoneme categorization required temporal processing. Overall, the results suggest that the observed atypicalities in speech perception in ASD, including the reduced sensitivity observed here, cannot be attributed merely to the limited ability to utilize context during speech perception.

Glioblastoma is a clinically and molecularly heterogeneous disease, and new predictive biomarkers are needed to identify those patients most likely to respond to specific treatments. Through prospective genomic profiling of 459 consecutive primary treatment-naïve IDH-wildtype glioblastomas in adults, we identified a unique subgroup (2%, 9/459) defined by somatic hypermutation and DNA replication repair deficiency due to biallelic inactivation of a canonical mismatch repair gene. The deleterious mutations in mismatch repair genes were often present in the germline in the heterozygous state with somatic inactivation of the remaining allele, consistent with glioblastomas arising due to underlying Lynch syndrome. A subset of tumors had accompanying proofreading domain mutations in the DNA polymerase POLE and resultant "ultrahypermutation". The median age at diagnosis was 50 years (range 27-78), compared with 63 years for the other 450 patients with conventional glioblastoma (p

Profound changes due to Open-Access (OA) publications lead to organizational changes in universities and libraries. This study examines Israeli librarians' perceptions regarding their role and the academic library's role in promoting OA-publications, including the barriers, challenges, needs, and requirements necessary to promote OA publishing. Lack of a budget for OA-agreements, no cooperation from university management, and researchers' unfamiliarity with OA were among the most prominent barriers. Librarians see great importance in their role of advising researchers regarding OA. However, they insist on a regulated OA-policy at the national and institutional levels to strengthen their status as change-leaders of the OA-movement.

Numerous studies have examined the positive and negative effects of various types of interactions that occur while children view electronic book (e-book) stories. However, the effects of the different types of interactions have not been compared, and more importantly, the optimal amount and reoccurrence of these interactions on children has not been explored. The present study was designed to fill this gap by examining the effect of amount, type and reoccurrence of e-book interactions on kindergarteners' new word learning and story comprehension. To do so, 72 children aged 5-6 year-old viewed three picture e-book stories in one session read by digital narrators, and then repeated this procedure in a second session. Each story included a word clarification or a story elaboration type of interaction, which occurred at low (every two screens), medium (every screen), or high frequency (more than once on most screens) during viewing. Following each story, participants were asked to define target words and answer comprehension questions. Results showed that increasing the amount of interactions, whether word clarifications or elaborations, enhanced word learning and story comprehension following the second exposure to the e-book stories. These findings suggest that interruptions during e-book viewing to explain difficult words or expand the plot by inferential information, do not interfere with the narrative course and do not impair learning processes, at least not in the amounts of interactions examined in this study. These conclusions bear practical implications for the design of e-books, and more generally, for the interactive approach adults may adopt when reading a story to children.

BACKGROUND: The presence of blebs increases the rupture risk of intracranial aneurysms (IAs). OBJECTIVE: To evaluate whether cross-sectional bleb formation models can identify aneurysms with focalized enlargement in longitudinal series. METHODS: Hemodynamic, geometric, and anatomical variables derived from computational fluid dynamics models of 2265 IAs from a cross-sectional dataset were used to train machine learning (ML) models for bleb development. ML algorithms, including logistic regression, random forest, bagging method, support vector machine, and K-nearest neighbors, were validated using an independent cross-sectional dataset of 266 IAs. The models ability to identify aneurysms with focalized enlargement was evaluated using a separate longitudinal dataset of 174 IAs. Model performance was quantified by the area under the receiving operating characteristic curve (AUC), the sensitivity and specificity, positive predictive value, negative predictive value, F1 score, balanced accuracy, and misclassification error. RESULTS: The final model, with three hemodynamic and four geometrical variables, along with aneurysm location and morphology, identified strong inflow jets, non-uniform wall shear stress with high peaks, larger sizes, and elongated shapes as indicators of a higher risk of focal growth over time. The logistic regression model demonstrated the best performance on the longitudinal series, achieving an AUC of 0.9, sensitivity of 85%, specificity of 75%, balanced accuracy of 80%, and a misclassification error of 21%. CONCLUSIONS: Models trained with cross-sectional data can identify aneurysms prone to future focalized growth with good accuracy. These models could potentially be used as early indicators of future risk in clinical practice.

BackgroundVariations in survival among patients with oligodendroglioma are unexplained by known prognostic factors. To assess the impact of peripheral immune profiles on prognosis, we applied immunomethylomics analyses-DNA methylation of archived whole blood samples, to characterize immune cells.MethodsWe compared the proportions of immune cells from patients with oligodendroglioma to other glioma subtypes and controls. We used recursive partitioning analysis (RPA) within the oligodendrogliomas to correlate with survival.ResultsPatients with oligodendrogliomas (141) were median age at diagnosis of 44 years; 57% male; 75% White; 60% prior chemotherapy; and 25% on dexamethasone at sample collection. Patients with oligodendrogliomas had immune profiles more similar to controls than other glioma subtypes, though with notably lower B-cells. RPA of patients with oligodendrogliomas delineated 2 survival groups based on an interaction between age and B-naïve cells. Patients with longer survival (median 24.2 years) were ≤42 years of age with higher B-naïve cells versus worse survival (median 16.9 years) who were ≤42 years of age with lower B-naïve cells or >42 years of age (P = .00032). Patients with worse survival also had lower CD4- and CD8-naïve T-cells. Similar immune profiles were observed in an independent cohort of oligodendroglioma patients prior to surgery.ConclusionsPeripheral blood immune profiles in oligodendroglioma suggested that younger patients with lower B-naïve cells experienced shorter survival. Though our findings lack of validation cohort and use a heterogenous patient population, they suggest peripheral blood immune profiles may be prognostic for patients with glioma and warrant further investigation.

Abstract Background Over 1.9 million Arabs live in Israel and constitute 21% of the total population. Despite being a disadvantaged minority population with wide gaps in health indicators, Arabs have higher Human Papillomavirus (HPV) and Measles, Mumps, and Rubella (MMR) vaccination rates compared with the general Jewish population. Methods In-depth interviews with 21 health care providers, 16 Arab mothers, and 16 teenagers were conducted to collect information about health system enablers to HPV and MMR vaccination. All interviews were conducted in Arabic by an Arab researcher, audio-recorded, transcribed, and analysed using thematic analysis of the transcripts. Themes were mapped according to the WHO Health Systems Building Block Framework. Results We identified several health system enablers. On the service delivery level, accessible and availability of vaccination services, delivery of vaccines through the school system and mother child clinics, and framing vaccinations as the norm were themes. Personable characteristics of the health workforce, the health care providers belonging to the same cultural group, and high levels of trust towards healthcare professionals were reported. Vaccination provided at no cost was also identified. On the leadership/governance level, the Arab community felt equal treatment and distribution of services, which was also an enabler reported. Despite high vaccine uptakes, parents and teenagers had limited knowledge regarding vaccination, particularly HPV. Conclusions This study highlights that a combination of good access and delivery to vaccination, delivered by a culturally competent, available, accessible respectful workforce can enable disadvantaged minorities to achieve high vaccine coverage, in particular in a cultural context where the population trusts and follows medical advice. Such evidence can serve as a basis for developing policies, interventions, and guidance to improve vaccine uptake among other underserved minority communities.

This interview in the journal Tracés looks at the issue of gender inequality in Prehistory. Researchers Anne Augereau, Claudine Cohen and Aline Thomas discuss the archaeological methods that can be used to document gender relations in the Palaeolithic and Neolithic periods and explain what is at stake in this research. In particular, they show how certain grand narratives stand in the way of our archaeological knowledge of gender and relations between men and women. Critically distancing ourselves from the idea of a “nature” that would underpin the sexual division of labour or from the myth of a primitive matriarchy is seen not only as a prerequisite for scientific knowledge of humanity’s past but also as a means of making a relevant contribution to current feminist issues.

Abstract In the current investigation, elemental boron was added to form a series of Ti53.3-xNb10Zr10Ni10Co10Fe6.7Bx Compositionally Complex Alloys (CCAs). Alloying was done via vacuum arc melting in amounts of 0.0, 5.3, and 10.6 at.%. From the thermodynamic parameters, adding B to the base alloy increased the system’s entropy. The microstructure of the prepared CCAs was characterized using scanning electron microscopy, transmission electron microscopy, and X-ray diffraction (XRD). The mechanical properties of CCAs as related to microstructure were assessed. According to XRD results, B-based intermetallic phases were obtained in the prepared CCAs, which were binary as Ti3B4 and ZrB2 and ternary as FeNbB and Nb3Co4B7. These intermetallic phases notably provided strengthening effects to the B-added alloys. Ti48Nb10Zr10Ni10Co10Fe6.7B5.3 CCA showed the most homogenous microstructure obtained by the arc melting process. Adding B increased Young’s modulus from 141 GPa (without B) to 195 GPa and 260 GPa with 5.3 and 10.6 at.%B, respectively. Hardness also increased from 502 to 606 HV with 5.3 at.% B and to 648 HV with 10.6 at.%B. Accordingly, the wear resistance increased with B addition where 10.6 at.%B sample showed the lowest wear rate among the other conditions. However, 5.3 at.% B was nominated as the optimum addition amount due to its notable microstructure homogeneity.

Abstract This study sought to investigate the demographic and clinical characteristics of Sudanese men diagnosed with prostate cancer (PCa) to highlight differences in diagnosis among the three major ethnolinguistic groups. A total of 532 patients with confirmed PCa diagnosis through biopsy were enrolled from six medical centers in Sudan. The majority of patients, comprising 84.2% (448/532), were diagnosed with advanced-stage disease, with a Grade group above 3. There were no discernible differences in PCa aggressiveness among the ethnolinguistic groups. However, higher levels of prostate-specific antigen (PSA) were observed in the Niger-Congo group, where 55.2% had PSA values exceeding 50 ng/ml. Patients from this group were also diagnosed at a younger age. In contrast, 90.5% of Afro-Asiatic patients are over 60 years old. Further analysis conducted within an age-matched subgroup of patients (n = 273) revealed a higher incidence of perineural invasion in the Afro-Asiatic group. This research represents the first investigation of PCa across different African ethnic groups and associates a higher incidence of perineural invasion with a specific ethnic group. While recent efforts have been made to establish African-relevant risk models to mitigate PCa health disparities, there remains a need for further investigation into genetically distinct populations within the African continent.