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1. Advancing West Nile virus monitoring through whole genome sequencing: Insights from a One Health genomic surveillance study in Romagna (Italy)

Author

Brandolini, Martina, De Pascali, Alessandra Mistral, Zaghi, Irene, Dirani, Giorgio, Zannoli, Silvia, Ingletto, Ludovica, Lavazza, Antonio, Lelli, Davide, Dottori, Michele, Calzolari, Mattia, Guerra, Massimiliano, Biagetti, Carlo, Cristini, Francesco, Bassi, Paolo, Biguzzi, Rino, Cricca, Monica, Scagliarini, Alessandra, and Sambri, Vittorio

Published
2024
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2. The Influence of Altitude, Urbanization, and Local Vaccination Centers on Vaccine Uptake within an Italian Health District: An Analysis of 15,000 Individuals Eligible for Vaccination

Author

Andrea Ceccarelli, Giorgia Soro, Chiara Reali, Emilia Biguzzi, Roberta Farneti, Valeria Frassineti, Raffaella Angelini, Gian Luigi Belloli, Davide Gori, and Marco Montalti

Subjects
vaccine confidence, vaccine coverage, vaccination campaign, barriers, epidemiology, Medicine
Abstract

In Italy, free vaccinations for Herpes Zoster (HZ), pneumococcal (PCV), and influenza (FLU) are recommended each year for individuals turning 65. Despite this, achieving optimal vaccination coverage remains challenging. This study assesses coverage rates for HZ, PCV, and FLU in Forlì, Northern Italy, and examines how altitude, urban planning, and health organization variables (such as the presence of a vaccination center) impact vaccine uptake. Vaccination coverages were calculated for birth cohorts between 1952 and 1958 for each municipality in the Forlì area as of 1 March 2024. The geographical factors influencing the vaccination uptake were extracted from the Italian National Institute of Statistics (ISTAT) records and evaluated through a multivariate analysis. The sample analyzed included 15,272 vaccine campaign targets from Forlì’s province (185,525 citizens); the vaccine uptake rates for HZ, PCV, and FLU were 26.9%, 36.7%, and 43.5%, respectively. Gender did not appear to influence vaccine uptake. Living in a flat area appeared to increase vaccine uptake in a statistically significant way for all the vaccinations when compared to a mountainous area (HZ: OR: 1.50, PCV: OR: 1.33, FLU: OR: 1.67). The presence of a vaccine service in low-urbanized areas was shown to increase vaccine uptake for all vaccinations (HZ: OR: 1.65, PCV: OR: 1.93, FLU: OR: 1.53) compared with low-urbanized areas without a vaccination center or more urbanized areas with a vaccination center. This study emphasizes the significance of the territorial context, along with the ease of access to vaccinations and geographic barriers, as key determinants in achieving vaccination targets. Local health authorities should consider these factors when implementing vaccination campaigns.

Published
2024
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4. Anti-PF4 immunothrombosis without proximate heparin or adenovirus vector vaccine exposure

Author

Schönborn, Linda, Esteban, Olga, Wesche, Jan, Dobosz, Paulina, Broto, Marta, Puig, Sara Rovira, Fuhrmann, Jessica, Torres, Raquel, Serra, Josep, Llevadot, Roser, Palicio, Marta, Wang, Jing Jing, Gordon, Tom Paul, Lindhoff-Last, Edelgard, Hoffmann, Till, Alberio, Lorenzo, Langer, Florian, Boehme, Christian, Biguzzi, Eugenia, Grosse, Leonie, Endres, Matthias, Liman, Thomas, Thiele, Thomas, Warkentin, Theodore E., and Greinacher, Andreas

Published
2023
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8. von Willebrand factor neutralizing and non-neutralizing alloantibodies in 213 subjects with type 3 von Willebrand disease enrolled in 3WINTERS-IPS

Author

Pagliari, Maria Teresa, Budde, Ulrich, Baronciani, Luciano, Eshghi, Peyman, Ahmadinejad, Minoo, Badiee, Zahra, Baghaipour, Mohammad-Reza, Benítez Hidalgo, Olga, Biguzzi, Eugenia, Bodó, Imre, Castaman, Giancarlo, Goudemand, Jenny, Karimi, Mehran, Keikhaei, Bijan, Lassila, Riitta, Leebeek, Frank W.G., Lopez Fernandez, Maria Fernanda, Marino, Renato, Oldenburg, Johannes, Peake, Ian, Santoro, Cristina, Schneppenheim, Reinhard, Tiede, Andreas, Toogeh, Gholamreza, Tosetto, Alberto, Trossaert, Marc, Yadegari, Hamideh, Zetterberg, Eva M.K., Mannucci, Pier Mannuccio, Federici, Augusto B., Eikenboom, Jeroen, and Peyvandi, Flora

Published
2023
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12. The Influence of Altitude, Urbanization, and Local Vaccination Centers on Vaccine Uptake within an Italian Health District: An Analysis of 15,000 Individuals Eligible for Vaccination.

Author

Ceccarelli, Andrea, Soro, Giorgia, Reali, Chiara, Biguzzi, Emilia, Farneti, Roberta, Frassineti, Valeria, Angelini, Raffaella, Belloli, Gian Luigi, Gori, Davide, and Montalti, Marco

Subjects
VACCINATION status, HERPES zoster vaccines, VACCINATION coverage, METROPOLITAN areas, INFLUENCE of altitude
Abstract

In Italy, free vaccinations for Herpes Zoster (HZ), pneumococcal (PCV), and influenza (FLU) are recommended each year for individuals turning 65. Despite this, achieving optimal vaccination coverage remains challenging. This study assesses coverage rates for HZ, PCV, and FLU in Forlì, Northern Italy, and examines how altitude, urban planning, and health organization variables (such as the presence of a vaccination center) impact vaccine uptake. Vaccination coverages were calculated for birth cohorts between 1952 and 1958 for each municipality in the Forlì area as of 1 March 2024. The geographical factors influencing the vaccination uptake were extracted from the Italian National Institute of Statistics (ISTAT) records and evaluated through a multivariate analysis. The sample analyzed included 15,272 vaccine campaign targets from Forlì's province (185,525 citizens); the vaccine uptake rates for HZ, PCV, and FLU were 26.9%, 36.7%, and 43.5%, respectively. Gender did not appear to influence vaccine uptake. Living in a flat area appeared to increase vaccine uptake in a statistically significant way for all the vaccinations when compared to a mountainous area (HZ: OR: 1.50, PCV: OR: 1.33, FLU: OR: 1.67). The presence of a vaccine service in low-urbanized areas was shown to increase vaccine uptake for all vaccinations (HZ: OR: 1.65, PCV: OR: 1.93, FLU: OR: 1.53) compared with low-urbanized areas without a vaccination center or more urbanized areas with a vaccination center. This study emphasizes the significance of the territorial context, along with the ease of access to vaccinations and geographic barriers, as key determinants in achieving vaccination targets. Local health authorities should consider these factors when implementing vaccination campaigns. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Direct thrombectomy for stroke in the presence of absolute exclusion criteria for thrombolysis

Author

Cappellari, Manuel, Pracucci, Giovanni, Forlivesi, Stefano, Saia, Valentina, Limbucci, Nicola, Nencini, Patrizia, Inzitari, Domenico, Da Ros, Valerio, Sallustio, Fabrizio, Vallone, Stefano, Bigliardi, Guido, Zini, Andrea, Vinci, Sergio Lucio, Dell’Aera, Cristina, Bracco, Sandra, Cioni, Samuele, Tassi, Rossana, Bergui, Mauro, Naldi, Andrea, Carità, Giuseppe, Azzini, Cristiano, Casetta, Ilaria, Gasparotti, Roberto, Magoni, Mauro, Castellan, Lucio, Finocchi, Cinzia, Menozzi, Roberto, Scoditti, Umberto, Causin, Francesco, Viaro, Federica, Puglielli, Edoardo, Casalena, Alfonsina, Ruggiero, Maria, Biguzzi, Sara, Castellano, Davide, Cavallo, Roberto, Lazzarotti, Guido Andrea, Orlandi, Giovanni, Sgreccia, Alessandro, Denaro, Maria Federica, Cavasin, Nicola, Critelli, Adriana, Ciceri, Elisa Francesca Maria, Bonetti, Bruno, Chiumarulo, Luigi, Petruzzelli, Marco, Pellegrino, Carlo, Carimati, Federico, Burdi, Nicola, Prontera, Maria Pia, Auteri, Wiliam, Petrone, Alfredo, Guidetti, Giulio, Nicolini, Ettore, Ganci, Giuseppe, Sugo, Annalisa, Filauri, Pietro, Sacco, Simona, Squassina, Guido, Invernizzi, Paolo, Nuzzi, Nunzio Paolo, Corato, Manuel, Amistà, Pietro, Gentile, Mauro, Barbero, Stefano, Schirru, Federica, Craparo, Giuseppe, Mannino, Marina, Simonetti, Luigi, Mangiafico, Salvatore, and Toni, Danilo

Published
2020
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20. Erratum to ‘A comparative study in type 2 von Willebrand disease patients using four different platelet-dependent von Willebrand factor assays.’ [Research and Practice in Thrombosis and Haemostasis Volume 7, Issue 3, March 2023, 100139]

Author

Colpani, Paola, primary, Baronciani, Luciano, additional, Stufano, Francesca, additional, Cozzi, Giovanna, additional, Boscarino, Marco, additional, Pagliari, Maria Teresa, additional, Biguzzi, Eugenia, additional, and Peyvandi, Flora, additional

Published
2023
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23. Thrombolysis after dabigatran reversal: A nation-wide Italian multicentre study, systematic review and meta-analysis

Author

Michele Romoli, Eleonora Matteo, Ludovica Migliaccio, Mauro Gentile, Maria Giulia Mosconi, Giuseppe Maria Scura, Marcello Naccarato, Enrico Colangeli, Paolo Candelaresi, Vincenzo Andreone, Fabrizio Giammello, Rosa Fortunata Musolino, Cristina Dell’Aera, Federica Nicoletta Sepe, Edoardo Pronello, Leonardo Barbarini, Marcella Caggiula, Federica Rizzo, Marco Petruzzellis, Elisa Giorli, Maria Luisa Zedde, Sabrina Anticoli, Marilena Mangiardi, Mario Muto, Francesco Diana, Maria Vittoria De Angelis, Anna Digiovanni, Letizia Concari, Sara La Gioia, Maria Sessa, Sara Biguzzi, Francesco Cordici, Marco Longoni, Maria Ruggiero, Silvia Cenciarelli, Paolo Eusebi, Simona Sacco, Valeria Caso, Maurizio Paciaroni, Stefano Ricci, Andrea Zini, Danilo Toni, and David Giannandrea

Subjects
Stroke, thrombolysis, thrombectomy, Original Research Articles, Neurology (clinical), antidote, direct oral anticoagulants, Cardiology and Cardiovascular Medicine
Abstract

Introduction: Recent anticoagulant intake represents a contraindication for thrombolysis in acute ischemic stroke. Idarucizumab reverses the anticoagulant effect of dabigatran, potentially allowing for thrombolysis. This nation-wide observational cohort study, systematic review, and meta-analysis evaluated the efficacy and safety of thrombolysis preceded by dabigatran-reversal in people with acute ischemic stroke. Patients and methods: We recruited people undergoing thrombolysis following dabigatran-reversal at 17 stroke centers in Italy (reversal-group), people on dabigatran treated with thrombolysis without reversal (no-reversal group), and age, sex, hypertension, stroke severity, and reperfusion treatment-matched controls in 1:7 ratio (control-group). We compared groups for symptomatic intracranial hemorrhage (sICH, main outcome), any brain hemorrhage, good functional outcome (mRS 0–2 at 3 months), and death. The systematic review followed a predefined protocol (CRD42017060274), and odds ratio (OR) meta-analysis was implemented to compare groups. Results: Thirty-nine patients in dabigatran-reversal group and 300 matched controls were included. Reversal was associated with a non-significant increase in sICH (10.3% vs 6%, aOR = 1.32, 95% CI = 0.39–4.52), death (17.9% vs 10%, aOR = 0.77, 95% CI = 0.12–4.93) and good functional outcome (64.1% vs 52.8%, aOR = 1.41, 95% CI = 0.63–3.19). No hemorrhagic events or deaths were registered in no-reversal group (n = 12). Pooling data from 3 studies after systematic review (n = 1879), reversal carried a non-significant trend for sICH (OR = 1.53, 95% CI = 0.67–3.50), death (OR = 1.53, 95% CI = 0.73–3.24) and good functional outcome (OR = 2.46, 95% CI = 0.85–7.16). Discussion and conclusion: People treated with reperfusion strategies after dabigatran reversal with idarucizumab seem to have a marginal increase in the risk of sICH but comparable functional recovery to matched patients with stroke. Further studies are needed to define treatment cost-effectiveness and potential thresholds in plasma dabigatran concentration for reversal.

Published
2022
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24. Comparison of Two Alternative Procedures to Obtain Packed Red Blood Cells for β-Thalassemia Major Transfusion Therapy

Author

Davide Schiroli, Lucia Merolle, Eleonora Quartieri, Roberta Chicchi, Tommaso Fasano, Tiziana De Luca, Giuseppe Molinari, Stefano Pulcini, Thelma A. Pertinhez, Erminia Di Bartolomeo, Rino Biguzzi, Roberto Baricchi, and Chiara Marraccini

Subjects
β-thalassemia, packed red blood cells, metabolites, iron overload, blood transfusion, Microbiology, QR1-502
Abstract

β-thalassemia major (βTM) patients require frequent blood transfusions, with consequences that span from allogenic reactions to iron overload. To minimize these effects, βTM patients periodically receive leucodepleted packed red blood cells (P-RBCs) stored for maximum 14 days. The aim of this study was to compare two alternative routine procedures to prepare the optimal P-RBCs product, in order to identify differences in their content that may somehow affect patients’ health and quality of life (QoL). In method 1, blood was leucodepleted and then separated to obtain P-RBCs, while in method 2 blood was separated and leucodepleted after removal of plasma and buffycoat. Forty blood donors were enrolled in two independent centers; couples of phenotypically matched whole blood units were pooled, divided in two identical bags and processed in parallel following the two methods. Biochemical properties, electrolytes and metabolic composition were tested after 2, 7 and 14 days of storage. Units prepared with both methods were confirmed to have all the requirements necessary for βTM transfusion therapy. Nevertheless, RBCs count and Hb content were found to be higher in method-1, while P-RBCs obtained with method 2 contained less K+, iron and storage lesions markers. Based on these results, both methods should be tested in a clinical perspective study to determine a possible reduction of transfusion-related complications, improving the QoL of βTM patients, which often need transfusions for the entire lifespan.

Published
2021
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27. Phenotypic and genetic characterizations of the Milan cohort of von Willebrand disease type 2

Author

Omid Seidizadeh, Luciano Baronciani, Maria Teresa Pagliari, Giovanna Cozzi, Paola Colpani, Andrea Cairo, Simona Maria Siboni, Eugenia Biguzzi, and Flora Peyvandi

Subjects
Male, von Willebrand Diseases, Genotype, Mutation, von Willebrand Factor, Humans, Female, von Willebrand Disease, Type 2, Hematology
Abstract

von Willebrand disease (VWD) type 2 is caused by qualitative abnormalities of von Willebrand factor (VWF). This study aimed to determine the genotypic and phenotypic characterizations of a large VWD type 2 cohort from Milan. We included 321 patients (54% female) within 148 unrelated families from 1995 to 2021. Patients were fully characterized using laboratory phenotypic tests, and the genotypic diagnosis was confirmed by target genetic analysis using Sanger sequencing. Patients were diagnosed with type 2A (n = 98; 48 families), 2B (n = 85; 38 families), 2M (n = 112; 50 families), or 2N (n = 26; 12 families). Eighty-two unique VWF variants, including 8 novel variants, were found. The potential pathogenic effect of novel variants was assessed by in silico analysis. Most patients were heterozygous for a single variant (n = 259; 81%), whereas 37 cases (11%) had 2 variants (4 homozygous, 9 in trans, and 24 in cis). Twenty-five patients (8%) had ≥3 variants, mainly as a result of gene conversions. Among the 82 distinct variants identified, 5 different types, including missense (n = 64), gene conversion (n = 10), synonymous (n = 1), deletion (n = 4), and splice (n = 3), were observed. The results from this large cohort showed that VWD type 2 is invariably due to variants that do not prevent the synthesis of the protein, and a vast majority of patients (88%) had missense variants. Given the complexity of type 2 diagnosis and the necessity of performing several phenotypic tests, genetic analysis for patients suspected of having type 2 is beneficial to establish the correct diagnosis.

Published
2022
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29. Risk of parenterally transmitted hepatitis following exposure to invasive procedures in Italy: SEIEVA surveillance 2000-2021

Author

Caminada, Susanna, primary, Mele, Annamaria, additional, Ferrigno, Luigina, additional, Alfonsi, Valeria, additional, Crateri, Simonetta, additional, Iantosca, Giuseppina, additional, Sabato, Marise, additional, Tosti, Maria Elena, additional, D’Angelo, Franca, additional, Zotti, Carla, additional, Marengo, Noemi, additional, Cornio, Alessandro Roberto, additional, Russotto, Antonino, additional, Scarvaglieri, Maria Elisabetta, additional, Gallone, Angela, additional, Zoia, Irene, additional, Torchio, Pierfederico, additional, Melcarne, Lucia, additional, Castagno, Paolo, additional, Bassetti, Saveria, additional, Dama, Erika, additional, Orlandi, Silvia, additional, Busso, Stefania, additional, Andreoletti, Michela, additional, Fontana, Manuela, additional, Rametta, Stefania, additional, Cranco, Rosita, additional, Bonacina, Alessandra, additional, Lioce, Duilio, additional, Ciprioti, Rosamary, additional, Cappello, Maria Teresa, additional, Palma, Anna Maria, additional, Musso, Claudia, additional, Bussolino, Paola, additional, Smaniotto, Alessandro, additional, Ruffier, Mario, additional, Verardo, Marina, additional, Cipriani, Alessandro, additional, Cereda, Danilo, additional, Senatore, Sabrina, additional, Donadini, Annalisa, additional, Nespoli, Carla, additional, Gennati, Giorgio, additional, Piro, Antonio, additional, Vezzosi, Luigi, additional, Conca, Matteo, additional, Romani, Michela, additional, Tortorella, Franco Paolo, additional, Merlini, Paola Elvira, additional, Di Caterina, Davide, additional, Faccini, Marino, additional, Lamberti, Anna, additional, Rossetti, Eva, additional, Brugnoli, Rita, additional, Mainardi, Giulia, additional, Vezzoli, Alessandra, additional, Caso, Daniela, additional, Testa, Milena, additional, Costa, Daniela, additional, Senegaglia, Paola, additional, Spagna, Annamaria, additional, Lodola, Silvia, additional, Riboli, Simona, additional, Giompapa, Enza, additional, Roveri, Luigi Guido, additional, Guardigli, Gabriele, additional, Scalvinoni, Vanna, additional, Lombarda, Elena, additional, Gasparri, Serena, additional, Spertini, Silvia, additional, Gamper, Sabine, additional, Moretto, Giacomo, additional, Kofler, Elisabeth, additional, Ploner, Barbara, additional, Runggatscher, Verena, additional, Molinaro, Silvia, additional, Zuccali, Maria Grazia, additional, Franchini, Silvia, additional, Russo, Francesca, additional, Zanella, Francesca, additional, Ballarin, Debora, additional, Fiorito, Nahuel, additional, Zallot, Chiara, additional, Cian, Serena, additional, Bonsembiante, Erminio, additional, Mattiuzzo, Elena, additional, Munarin, Ludovica, additional, Palazzi, Barbara, additional, Sulaj, Arda, additional, Boin, Federica, additional, Carraro, Daniele, additional, Codolo, Antonella, additional, Fragapane, Marilena, additional, Formaglio, Andrea, additional, Giacobbe, Donatella, additional, Fenzi, Federica, additional, Gottardello, Lorena, additional, Cannizzo, Elisabetta, additional, Ceccon, Giulia, additional, De Stefani, Emanuela, additional, Casagrande, Paola, additional, Zotto, Alessandra Dal, additional, Zotto, Rita Dal, additional, Carlotto, Antonio, additional, Zorzi, Gemma, additional, Ivanovska, Sandra, additional, Postiglione, Chiara, additional, Colucci, Laura, additional, Rocco, Giulio, additional, Stacul, Rossana, additional, Breda, Ariella, additional, Bortolossi, Marisa, additional, Iob, Andrea, additional, Micossi, Simonetta, additional, Feltrin, Oriana, additional, Caernelos, Giuseppina, additional, Mela, Marco, additional, Frumento, Virna, additional, Opisso, Anna, additional, Cuccu, Alessandro, additional, Carpi, Antonella, additional, Giuffra, Paola, additional, Torracca, Francesca, additional, Castiglioni, Laura, additional, Mattei, Giovanna, additional, Gualanduzzi, Claudio, additional, Massimiliani, Erika, additional, Rampini, Alessandra, additional, Paglioli, Silvia, additional, Bisaccia, Eufemia, additional, Roversi, Sandra, additional, Resi, Davide, additional, Prengka, Anna, additional, Califano, Annalisa, additional, Santoro, Viviana, additional, Biguzzi, Emilia, additional, Reali, Chiara, additional, Morri, Michela, additional, Senatore, Daniela, additional, Balocchini, Emanuela, additional, Pierozzi, Costanza, additional, Angio, Francesco, additional, Kundisova, Lucia, additional, Isola, Alda, additional, Cecconi, Rossella, additional, Berti, Cristiana, additional, Matarazzo, Francesca, additional, Zini, Paola, additional, Staderini, Chiara, additional, Cordella, Vincenzo, additional, Brugnoli, Sara, additional, Sacchelli, Francesco, additional, Lucchesi, Lara, additional, Luzzoli, Rosa, additional, Gandolfo, Silvia, additional, Cibeca, Piero, additional, Galletti, Nicoletta, additional, Aquino, Francesco, additional, Lari, Maria, additional, Poropat, Roberta, additional, Ferrini, Rita, additional, Barbieri, Alessandro, additional, Conti, Vito, additional, Canale, Alice, additional, Moretti, Katia, additional, Buccino, Aniello, additional, Bartoli, Ilaria, additional, Cioni, Silvia, additional, Gennari, Giulia, additional, Rapaccini, Fabiola, additional, Bekshiu, Lumturi, additional, Zacchini, Federica, additional, Romani, Davide, additional, Sansone, Monica, additional, Foresi, Simona, additional, Piattellini, Giovanni, additional, Pasquale, Anna, additional, Brancaleoni, Maria Grazia, additional, Santocchia, Franco, additional, Proietti, Maria Laura, additional, Fiacchini, Daniel, additional, Giamprini, Maria Sole, additional, Iacobellis, Mariangela, additional, Van Will, Jacqueline, additional, Vaccaro, Alfredo, additional, Sbarbati, Maria Margherita, additional, Amelio, Alessandra, additional, Cimini, Daniela, additional, Moroni, Vania, additional, Francoletti, Daniela, additional, Marcellini, Mirella, additional, Scaccia, Federica, additional, Branchesi, Elisabetta, additional, Saracino, Selena, additional, Mezzanotte, Catia, additional, Cimica, Susanna, additional, Vitale, Vita, additional, Laici, Franca, additional, Petrelli, Irene, additional, Airini, Barbara, additional, Passarini, Gabriella, additional, Ruffini, Lucia, additional, Lambertucci, Anna Maria, additional, Mogetta, Annarita, additional, Ciarrocchi, Giuseppe, additional, Pistolesi, Marina, additional, Fratello, Erika, additional, Picciotti, Francesca, additional, Contrisciani, Roberta, additional, Angelini, Claudio, additional, Ribiscini, Silvia, additional, Scognamiglio, Paola, additional, Vairo, Francesco, additional, De Santis, Claudia, additional, Miglietta, Antonio Salvatore, additional, Colosi, Alberto, additional, Loffredo, Maria Rosaria, additional, Esterini, Giorgio, additional, Pendenza, Alessio, additional, Nappi, Maria Rosaria, additional, Casagni, Luca, additional, Santucci, Luigi, additional, Montecchi, Margherita, additional, Mangiagli, Franca, additional, Aquilani, Silvia, additional, Di Luzio, Giuseppe, additional, Provvidenti, Luca, additional, Giambi, Cristina, additional, Di Giacomo, Manuela, additional, Giansanti, Enrico, additional, Mancini, Cristiana, additional, Turchi, Claudio, additional, Soldato, Graziella, additional, D'Eugenio, Felesina, additional, Albanesi, Ida, additional, Montanaro, Carmen, additional, Di Giorgio, Giovanni, additional, Prozzo, Alessandra, additional, Sabatini, Paola, additional, Simonelli, Mena, additional, Morrone, Gaetano, additional, Citarella, Annarita, additional, Fossi, Elena, additional, Alfieri, Rosa, additional, Scotto, Milena, additional, Caiazzo, Anna Luisa, additional, Liquori, Antonia, additional, Chironna, Maria, additional, Prato, Rosa, additional, Martinelli, Domenico, additional, Fortunato, Francesca, additional, Cappelli, Maria Giovanna, additional, Loconsole, Daniela, additional, Morea, Anna, additional, Del Matto, Giulia, additional, Maluccio, Maria Giuseppina, additional, Pedote, Pasquale, additional, Termite, Stefano, additional, Cambria, Roberta, additional, Caputi, Giovanni, additional, Cipriani, Rosati, additional, Desiante, Francesco, additional, Menolascina, Stefania, additional, Laforgia, Vera, additional, Squicciarini, Rosella, additional, Vitale, Viviana, additional, Matera, Anna Maria, additional, Pagone, Onofrio, additional, Avella, Grazia Maria, additional, Madaro, Antonino, additional, Angelillis, Raffaele, additional, Moffa, Giuseppina, additional, Nesta, Maria, additional, De Santis, Carlo, additional, Ferraro, Marisa, additional, Aprile, Valerio, additional, Antonazzo, Marcello, additional, Laugello, Giovanni, additional, Mignuoli, Anna Domenica, additional, Afflitto, Giuseppe, additional, Caroleo, Benedetto, additional, Scrivano, Francesca, additional, Maradei, Antonio, additional, Romeo, Rocco Cataldo, additional, Zucco, Rossella, additional, Coscarelli, Pierluigi, additional, Bisbano, Alessandro, additional, Monesanti, Maria, additional, De Giorgio, Vincenzo, additional, Giordano, Antonella, additional, Mammì, Pier Domenico, additional, Lazzarino, Elisa, additional, Surace, Vittoria, additional, Mangione, Rossana, additional, Meli, Valentina, additional, Cuccia, Mario, additional, Longhitano, Elena, additional, Delogu, Fiorenzo, additional, Fracasso, Donatella, additional, Marceddu, Maria Vittoria, additional, Flore, Loredana, additional, Eugenia Marras, Maria Valentina, additional, Serpi, Rita, additional, Campus, Marco, additional, and Raggio, Alessia, additional

Published
2023
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33. Heparin- and Vaccine-Independent Anti-Platelet Factor 4 Immunothrombosis

Author

Schönborn, Linda, primary, Esteban, Olga, additional, Wesche, Jan, additional, Dobosz, Paulina, additional, Broto, Marta, additional, Rovira Puig, Sara, additional, Fuhrmann, Jessica, additional, Torres, Raquel, additional, Serra, Josep, additional, Llevadot, Roser, additional, Palicio, Marta, additional, Wang, Jing Jing, additional, Gordon, Tom, additional, Lindhoff-Last, Edelgard, additional, Hoffmann, Till, additional, Alberio, Lorenzo, additional, Langer, Florian, additional, Boehme, Christian, additional, Biguzzi, Eugenia, additional, Grosse, Leonie, additional, Endres, Matthias, additional, Liman, Thomas, additional, Thiele, Thomas, additional, Warkentin, Theodore, additional, and Greinacher, Andreas, additional

Published
2023
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37. Thrombolysis after dabigatran reversal: A nation-wide Italian multicentre study, systematic review and meta-analysis

Author

Romoli, Michele, primary, Matteo, Eleonora, additional, Migliaccio, Ludovica, additional, Gentile, Mauro, additional, Mosconi, Maria Giulia, additional, Scura, Giuseppe Maria, additional, Naccarato, Marcello, additional, Colangeli, Enrico, additional, Candelaresi, Paolo, additional, Andreone, Vincenzo, additional, Giammello, Fabrizio, additional, Fortunata Musolino, Rosa, additional, Dell’Aera, Cristina, additional, Sepe, Federica Nicoletta, additional, Pronello, Edoardo, additional, Barbarini, Leonardo, additional, Caggiula, Marcella, additional, Rizzo, Federica, additional, Petruzzellis, Marco, additional, Giorli, Elisa, additional, Zedde, Maria Luisa, additional, Anticoli, Sabrina, additional, Mangiardi, Marilena, additional, Muto, Mario, additional, Diana, Francesco, additional, De Angelis, Maria Vittoria, additional, Digiovanni, Anna, additional, Concari, Letizia, additional, La Gioia, Sara, additional, Sessa, Maria, additional, Biguzzi, Sara, additional, Cordici, Francesco, additional, Longoni, Marco, additional, Ruggiero, Maria, additional, Cenciarelli, Silvia, additional, Eusebi, Paolo, additional, Sacco, Simona, additional, Caso, Valeria, additional, Paciaroni, Maurizio, additional, Ricci, Stefano, additional, Zini, Andrea, additional, Toni, Danilo, additional, and Giannandrea, David, additional

Published
2022
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40. Real‐world data on emicizumab prophylaxis in the Milan cohort

Author

Sara Arcudi, Roberta Gualtierotti, Sonia Marino, Gabriella Nicolò, Eugenia Biguzzi, Alessandro Ciavarella, Marco Boscarino, Simona Maria Siboni, Lucia Schiavone, Cristina Novembrino, Carla Valsecchi, and Flora Peyvandi

Subjects
Cohort Studies, Factor VIII, Antibodies, Bispecific, Humans, Hematology, General Medicine, Antibodies, Monoclonal, Humanized, Hemophilia A, Genetics (clinical)
Published
2022
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41. Heterogeneity in ALSFRS-R decline and survival: a population-based study in Italy

Author

Mandrioli, Jessica, Biguzzi, Sara, Guidi, Carlo, Sette, Elisabetta, Terlizzi, Emilio, Ravasio, Alessandro, Casmiro, Mario, Salvi, Fabrizio, Liguori, Rocco, Rizzi, Romana, Pietrini, Vladimiro, Borghi, Annamaria, Rinaldi, Rita, Fini, Nicola, Chierici, Elisabetta, Santangelo, Mario, Granieri, Enrico, Mussuto, Vittoria, De Pasqua, Silvia, Georgoulopoulou, Eleni, Fasano, Antonio, Ferro, Salvatore, D’Alessandro, Roberto, and ERRALS Group

Published
2015
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42. Impact of the preparation method of red cell concentrates on transfusion indices in thalassemia patients: A randomized crossover clinical trial

Author

Roberto Reverberi, Elena Borotti, Maria Vittoria Riontino, Roberta Chicchi, M. R. Gamberini, Ruggero Buonocore, Daniela Lasagni, Giuseppina Angela Portararo, Monica Fortini, Eleonora Calori, Donatella Venturelli, Francesco Fagnoni, Maurizio Govoni, Alice Stievano, G. Ceccherelli, and Rino Biguzzi

Subjects
Adult, Male, medicine.medical_specialty, Erythrocytes, Thalassemia, Immunology, Buffy coat, 030204 cardiovascular system & hematology, urologic and male genital diseases, Gastroenterology, Hemoglobins, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Humans, Immunology and Allergy, Medicine, Prospective Studies, Whole blood, Cross-Over Studies, Red Cell, Transfusion Medicine, business.industry, Transfusion Reaction, Plasmapheresis, Hematology, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, Clinical trial, Treatment Outcome, Leukoreduction, Quartile, Female, Hemoglobin, Leukocyte Reduction Procedures, Erythrocyte Transfusion, business, RBC transfusion, 030215 immunology
Abstract

Background The average hemoglobin content of red cell concentrates (RCC) varies depending on the method of preparation. Surprisingly less data are available concerning the clinical impact of those differences. Study Design and Methods The effects of two types of RCC (RCC‐A, RCC‐B) on transfusion regime were compared in a non‐blinded, prospective, randomized, two‐period, and crossover clinical trial. RCC‐A was obtained by whole blood leukoreduction and subsequent plasma removal, RCC‐B removing plasma and buffy coat first, followed by leukoreduction. Eligible patients were adult, with transfusion‐dependent thalassemia (TDT). Results RCC‐A contained 63.9 (60.3–67.8) grams of hemoglobin per unit (median with 1st and 3rd quartile), RCC‐B 54.5 (51.0–58.2) g/unit. Fifty‐one patients completed the study. With RCC‐B, the average pre‐transfusion hemoglobin concentration was 9.3 ± 0.5 g/dl (mean ± SD), the average transfusion interval 14.2 (13.7–16.3) days, the number of RCC units transfused per year 39.3 (35.4–47.3), and the transfusion power index (a composite index) 258 ± 49. With RCC‐A, the average pre‐transfusion hemoglobin concentration was 9.6 ± 0.5 g/dl (+2.7%, effect size 0.792), the average transfusion interval 14.8 (14.0–18.5) days (+4.1%, effect size 0.800), the number of RCC units transfused per year 34.8 (32.1–42.5) (−11.4%, effect size −1.609), and the transfusion power index 272 ± 61 (+14.1%, effect size 0.997). All differences were statistically highly significant (p

Published
2021
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43. Real‐world data on emicizumab prophylaxis in the Milan cohort

Author

Arcudi, Sara, primary, Gualtierotti, Roberta, additional, Marino, Sonia, additional, Nicolò, Gabriella, additional, Biguzzi, Eugenia, additional, Ciavarella, Alessandro, additional, Boscarino, Marco, additional, Siboni, Simona Maria, additional, Schiavone, Lucia, additional, Novembrino, Cristina, additional, Valsecchi, Carla, additional, and Peyvandi, Flora, additional

Published
2022
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46. Successful Chemical Synovectomy in a Patient with Acquired von Willebrand Syndrome with Chronic Synovitis Due to Recurrent Knee Hemarthrosis: A Case Report

Author

Roberta Gualtierotti, Claudio De Magistris, Eugenia Biguzzi, Jacopo Acquati Lozej, Alessandra Iurlo, Luigi Piero Solimeno, and Flora Peyvandi

Subjects
Settore MED/09 - Medicina Interna, Rheumatology, Hemarthrosis, Settore MED/33 - Malattie Apparato Locomotore, Immunology and Allergy, Acquired von Willebrand syndrome, Chemical synovectomy, Settore MED/15 - Malattie del Sangue
Abstract

Acquired von Willebrand syndrome (AVWS) is a rare, non-hereditary bleeding disorder related to heterogeneous medical conditions such as hematological malignancies and cardiovascular and autoimmune diseases. We describe the clinical course of a 62-year-old man with polycythemia vera who experienced post-traumatic knee and leg swelling due to hemarthrosis. He was treated at another center with low molecular weight heparin due to misdiagnosed deep vein thrombosis further exacerbating the ongoing bleeding. At our center, he was diagnosed with AVWS with reduced von Willebrand factor (VWF):GPIbR plasma activity and loss of high molecular weight multimers (HMWM). He was treated with compressive bandages with resolution. Five months later, on clinical recurrence of knee and leg swelling, knee ultrasound scan showed the presence of chronic synovitis and a hemorrhagic Baker's cyst with signs of rupture. The treatment consisted of chemical synovectomy with rifampicin and steroids preceded by systemic replacement therapy using plasma-derived factor VIII-VWF concentrate. At the end of the treatment cycle, our patient reported complete resolution of knee pain and restoration of joint range of motion and function. Ultrasound evaluation confirmed complete resolution of knee capsule distension and Baker's cyst. Hemarthrosis is an anecdotal presentation of AVWS and chemical synovectomy was successful in treating this complication. A multidisciplinary approach allowed an effective management of this rare complication.

Published
2022

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