660,650 results on '"A Arnold"'
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2. Does Charter School Autonomy Improve Matching of Teacher Attributes with Student Needs? EdWorkingPaper No. 24-1049
- Author
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Annenberg Institute for School Reform at Brown University, Jane Arnold Lincove, Salem Rogers, Alex Handler, Tara Kilbride, and Katharine O. Strunk
- Abstract
We examine the efficiency of traditional school districts versus charter schools in providing students with teachers who meet their demographic and education needs. Using panel data from the state of Michigan, we estimate the relationship between enrollment of Black, Hispanic, special education, and English learner students and the presence of Black, Hispanic, Special Education, and ESL teachers, and test whether this relationship differs at charter and traditional district-run schools. Because charter schools typically have less market power in hiring than large districts, we compare charter school employment practices to traditional public schools in districts of comparable size. Our results suggest that charter schools are more likely to employ same race teachers for Black students but not Hispanic students, and districts schools are slightly better at providing ESL and SPED teachers. We conclude that charter autonomy does not necessary generate better student-teacher matches, but Michigan charters may occupy a market niche by serving Black students and staffing Black teachers.
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- 2024
3. Do Mid-Career Teacher Trainees Enter and Persist Like Their Younger Peers? EdWorkingPaper No. 24-1015
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Annenberg Institute for School Reform at Brown University, Salem Rogers, and Jane Arnold Lincove
- Abstract
In the context of an ongoing national conversation about teacher shortages, we build on prior literature on the efficacy of teacher certification pathways by comparing entry and exit patterns based on age at the time of certification. All trainees who complete a state certification process have invested substantial time and resources into entering teaching. Competing employment opportunities and expectations might vary with age. We use both linear regression and discrete-time hazard models to examine employment and subsequent exit of newly certified teacher trainees in Michigan from 2011 to 2023. We find that while mid-career entrants in their 30s and 40s compose a small share of new certificates, they are more likely to enter a teaching position and no more likely to subsequently exit than counterparts who were certified in their early 20s. Mid-career pathways also contribute to teacher diversity by attracting more Black and male teachers who enter and persist.
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- 2024
4. The Effects of a Statewide Ban on School Suspensions. EdWorkingPaper No. 24-1004
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Annenberg Institute for School Reform at Brown University, Jane Arnold Lincove, Catherine Mata, and Kalena E. Cortes
- Abstract
This research uses the implementation of a school suspension ban in Maryland to test whether a top-down state-initiated ban on suspensions in early primary grades can influence school behavior regarding school discipline. Beginning in the fall of 2017, the State of Maryland banned the use of out-of-school suspensions for grades PK-2, unless a student posed an "imminent threat" to staff or students. This research investigates (1) what was the effect of the ban on discipline outcomes for students in both treated grades and upper elementary grades not subject to the ban? (2) did schools bypass the ban by coding more events as threatening or increasing the use of in-school suspensions? and (3) were there differential effects for students in groups that are historically suspended more often? Using a comparative interrupted time series strategy, we find that the ban is associated with a substantial reduction in, but not a total elimination of, out-of-school suspensions for targeted grades without substitution of in-school suspensions. Disproportionalities by race and other characteristics remain after the ban. Grades not subject to the ban experienced few effects, suggesting the ban did not trigger a schoolwide response that reduced exclusionary discipline.
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- 2024
5. Intellectual Capital Measurement in Higher Education Institutions Context from the Professors Perspective
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Yuranis Vargas-Atencio, Julio Cesar Acosta-Prado, and Arnold Alejandro Tafur-Mendoza
- Abstract
Intellectual capital has aroused growing interest in higher education; however, one area for improvement in its study is how to measure it adequately. Therefore, it is necessary to have instruments based on current models of intellectual capital. This study aims to design and validate an intellectual capital measurement scale in accredited higher education institutions (HEIs) from the perspective of professors. The study was instrumental because a measurement scale was developed. The sample consisted of 341 professors from six accredited HEIs on the Colombian Caribbean Coast. The statistical analysis consisted of three stages: item analysis, collection of validity evidence based on the internal structure and the relationship with other variables, and reliability analysis using the internal consistency method. The scale's internal structure corroborated intellectual capital composition based on human, structural, and relational components. Regarding convergent evidence, all variables possess this source of validity evidence. Reliability levels were also good. Previously, an instrument has yet to be developed those measures intellectual capital in HEIs from the perspective of professors. This study provides a scale that focuses on the characteristics of this stakeholder and is based on an innovative model of intellectual capital composed of human, structural, and relational capital. The theoretical contribution of the study lies in developing a test based on two current models of intellectual capital: the Intellectus model and the Balanced Scorecard model. It also contributes to practice by providing a tool for measuring intellectual capital that allows its adequate management, improvement, and decision-making within higher education.
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- 2024
6. Decoupling Pulse Tube Vibrations from a Dry Dilution Refrigerator at milli-Kelvin Temperatures
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The NUCLEUS collaboration, Wex, A., Rothe, J., Peters, L., Abele, H., Angloher, G., Arnold, B., Corona, M. Atzori, Bento, A., Bossio, E., Burkhart, J., Canonica, L., Cappella, F., Cappelli, M., Casali, N., Cerulli, R., Cruciani, A., Del Castello, G., Roccagiovine, M. del Gallo, Doblhammer, A., Dorer, S., Erhart, A., Friedl, M., Fichtinger, S., Garai, A., Ghete, V. M., Giammei, M., Goupy, C., Hauff, D., Jeanneau, F., Jericha, E., Kaznacheeva, M., Kinast, A., Kluck, H., Langenkämper, A., Lasserre, T., Lhuillier, D., Mancuso, M., Martin, R., Mauri, B., Mazzolari, A., Mazzucato, E., Neyrial, H., Nones, C., Oberauer, L., Ortmann, T., Pattavina, L., Petricca, F., Potzel, W., Pröbst, F., Pucci, F., Reindl, F., Romagnoni, M., Schermer, N., Schieck, J., Schönert, S., Schwertner, C., Scola, L., Soum-Sidikov, G., Stodolsky, L., Strauss, R., Tamisari, M., Thalmeier, R., Tomei, C., Vignati, M., Vivier, M., and Wagner, V.
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Physics - Instrumentation and Detectors - Abstract
With the rising adoption of dry dilution refrigerators across scientific and industrial domains, there has been a pressing demand for highly efficient vibration decoupling systems capable of operation at cryogenic temperatures in order to achieve the low vibration levels required for operation of sensitive equipment like cryogenic detectors or quantum devices. As part of the NUCLEUS experiment, a cryogenic spring pendulum has been engineered to effectively isolate pulse tube vibrations by establishing an autonomous frame of reference for the experimental volume, while sustaining temperatures below 10 mK. Attaining attenuation of up to two orders of magnitude within the region of interest of the NUCLEUS cryogenic detectors, we achieved displacement RMS values in the order of 1 nm in the axial direction and 100 pm radially, thereby reducing vibrations below typical environmental levels. Our successful detector operation across multiple cooldown cycles demonstrated negligible sensitivity to pulse tube induced vibrations, culminating in the achievement of an ultra-low $(6.22 \pm 0.07)$ eV baseline resolution on a gram-scale CaWO$_4$ cryogenic calorimeter during continuous pulse tube operation over the course of several weeks.
- Published
- 2025
7. Knife-Edge Diffraction of Scalar and Vector Vortex Light
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Maduro, Richard Aguiar, Fritsch, Amanda Kronhardt, and Franke-Arnold, Sonja
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Physics - Optics - Abstract
Various methods have been introduced to measure the orbital angular momentum (OAM) of light, from fork holograms to Dove prism interferometers, from tilted lenses to triangular apertures - each with their own benefits and limitations. Here we demonstrate how simple knife-edge diffraction can be used to identify the OAM of an optical phase vortex from the formation of fork dislocations within the Fresnel diffraction pattern. For vector vortex beams without net OAM, the conventional Fresnel fringes are recovered, whereas the polarization in the geometric shadow is changed in its ellipticity. The observed diffraction patterns agree with simulations and their features can be explained by considering diffraction as an interference phenomenon. Knife-edge diffraction provides not only an instructive illustration of various properties of phase and polarization vortices, but can also serve as an ideal method for the quick determination of optical OAM, with potential applications beyond optics, where alternative detection measurement methods may be harder to realize., Comment: 6 pages and 5 figures
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- 2025
8. Modeling measurements for quantitative imaging subsurface targets
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Kim, Arnold and Tsogka, Chrysoula
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Electrical Engineering and Systems Science - Signal Processing ,Physics - Geophysics - Abstract
We study ground-penetrating synthetic aperture radar measurements of scattering by targets located below a rough air-soil interface. By considering the inherent space/angle limitations of this imaging modality, we introduce a simplified model for measurements. This model assumes (i) first-order interactions between the target and the air-soil interface, (ii) scattering by the target below a flat air-soil interface, and (iii) a point target model. Using the method of fundamental solutions to simulate two-dimensional simulations of scalar waves for the direct scattering problem, we systematically study each of these data modeling assumptions. To test and validate these assumptions, we apply principal component analysis to approximately remove ground bounce signals from measurements and then apply Kirchhoff migration on that processed data to produce images. We show that images using this modeled data are nearly identical to those that use simulated measurements from the full direct scattering problem. In that way, we show that this model contains the essential information contained in measurements. Consequently, it provides a theoretical framework for understanding how inherent space/angle limitations affect subsurface imaging systems.
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- 2025
9. Adverse Weather Conditions Augmentation of LiDAR Scenes with Latent Diffusion Models
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Matteazzi, Andrea, Colling, Pascal, Arnold, Michael, and Tutsch, Dietmar
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Computer Science - Computer Vision and Pattern Recognition - Abstract
LiDAR scenes constitute a fundamental source for several autonomous driving applications. Despite the existence of several datasets, scenes from adverse weather conditions are rarely available. This limits the robustness of downstream machine learning models, and restrains the reliability of autonomous driving systems in particular locations and seasons. Collecting feature-diverse scenes under adverse weather conditions is challenging due to seasonal limitations. Generative models are therefore essentials, especially for generating adverse weather conditions for specific driving scenarios. In our work, we propose a latent diffusion process constituted by autoencoder and latent diffusion models. Moreover, we leverage the clear condition LiDAR scenes with a postprocessing step to improve the realism of the generated adverse weather condition scenes., Comment: This is an intermediate version of our work
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- 2025
10. Scattering by nanoplasmonic mesoscale assemblies
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Khan, Md. Imran, Ghosh, Sayantani, and Kim, Arnold D.
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Physics - Optics ,Physics - Computational Physics - Abstract
The flexibility and versatility of nanoassembled plasmonic structures provide platforms for mesoscale tunable optical modulation. Our recently developed model for these nanoassembled plasmonic structures is composed of a dielectric spherical core surrounded by a concentric spherical shell containing a random distribution of AuNPs. This model provides a useful platform for studying the role of a controlled amount of disorder on scattering by a particle. In that context, we explore the angular distribution of scattered light for different sizes (5 - 20 nm) and filling fractions (0.1 - 0.3) of the AuNP in the coatings. The simulations reveal that the coating of AuNPs redistributes power in a way that suppresses angular side lobes, thereby guiding the scattered power preferentially in the forward direction. These results highlight that with the ability to tune both the spatial and the spectral aspects of the scattering profile, these coated structures may serve as a platform for a variety of applications, including passive cloaking, scattering enhancement, and high-resolution imaging.
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- 2024
11. Highway Dimension: a Metric View
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Feldmann, Andreas Emil and Filtser, Arnold
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Computer Science - Data Structures and Algorithms - Abstract
Realistic metric spaces (such as road/transportation networks) tend to be much more algorithmically tractable than general metrics. In an attempt to formalize this intuition, Abraham et al. (SODA 2010, JACM 2016) introduced the notion of highway dimension. A weighted graph $G$ has highway dimension $h$ if for every ball $B$ of radius $\approx 4r$ there is a hitting set of size $h$ hitting all the shortest paths of length $>r$ in $B$. Unfortunately, this definition fails to incorporate some very natural metric spaces such as the grid graph, and the Euclidean plane. We relax the definition of highway dimension by demanding to hit only approximate shortest paths. In addition to generalizing the original definition, this new definition also incorporates all doubling spaces (in particular the grid graph and the Euclidean plane). We then construct a PTAS for TSP under this new definition (improving a QPTAS w.r.t. the original more restrictive definition of Feldmann et al. (SICOMP 2018)). Finally, we develop a basic metric toolkit for spaces with small highway dimension by constructing padded decompositions, sparse covers/partitions, and tree covers. An abundance of applications follow.
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- 2024
12. Roadmap on Quantum Magnetic Materials
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Grubišić-Čabo, Antonija, Guimarães, Marcos H. D., Afanasiev, Dmytro, Aguilar, Jose H. Garcia, Aguilera, Irene, Ali, Mazhar N., Bhattacharyya, Semonti, Blanter, Yaroslav M., Bosma, Rixt, Cheng, Zhiyuan, Dan, Zhiying, Dash, Saroj P., Dueñas, Joaquín Medina, Fernandez-Rossier, Joaquín, Gibertini, Marco, Grytsiuk, Sergii, Houmes, Maurits J. A., Isaeva, Anna, Knekna, Chrystalla, Kole, Arnold H., Kurdi, Samer, Lado, Jose, Mañas-Valero, Samuel, Lopes, J. Marcelo J., Marian, Damiano, Na, Mengxing, Pabst, Falk, Pierantoni, Sergio Barquero, Regout, Mexx, Reho, Riccardo, Rösner, Malte, Sanz, David, van der Sar, Toeno, Sławińska, Jagoda, Verstraete, Matthieu J., Waseem, Muhammad, van der Zant, Herre S. J., Zanolli, Zeila, and Soriano, David
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Fundamental research on two-dimensional (2D) magnetic systems based on van der Waals materials has been gaining traction rapidly since their recent discovery. With the increase of recent knowledge, it has become clear that such materials have also a strong potential for applications in devices that combine magnetism with electronics, optics, and nanomechanics. Nonetheless, many challenges still lay ahead. Several fundamental aspects of 2D magnetic materials are still unknown or poorly understood, such as their often-complicated electronic structure, optical properties, and magnetization dynamics, and their magnon spectrum. To elucidate their properties and facilitate integration in devices, advanced characterization techniques and theoretical frameworks need to be developed or adapted. Moreover, developing synthesis methods which increase critical temperatures and achieve large-scale, high-quality homogeneous thin films is crucial before these materials can be used for real-world applications. Therefore, the field of 2D magnetic materials provides many challenges and opportunities for the discovery and exploration of new phenomena, as well as the development of new applications. This Roadmap presents the background, challenges, and potential research directions for various relevant topics in the field on the fundamentals, synthesis, characterization, and applications. We hope that this work can provide a strong starting point for young researchers in the field and provide a general overview of the key challenges for more experienced researchers., Comment: 87 pages, 24 figures. Roadmap based on the discussions during the workshop on Quantum Magnetic Materials hosted by the Lorentz Centre in Leiden, the Netherlands (Oct. 2023)
- Published
- 2024
13. Energy scaling in a compact bulk multi-pass cell enabled by Laguerre-Gaussian single-vortex beams
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Koltalo, Victor, Westerberg, Saga, Redon, Melvin, Beaufort, Gaspard, Raab, Ann-Kathrin, Guo, Chen, Arnold, Cord L., and Viotti, Anne-Lise
- Subjects
Physics - Optics - Abstract
We report pulse energy scaling enabled by the use of Laguerre-Gaussian single-vortex ($\text{LG}_{0,l}$) beams for spectral broadening in a sub-40 cm long Herriott-type bulk multi-pass cell. Beams with orders ${l= 1-3}$ are generated by a spatial light modulator, which facilitates rapid and precise reconfiguration of the experimental conditions. 180 fs pulses with 610 uJ pulse energy are post-compressed to 44 fs using an $\text{LG}_{0,3}$ beam, boosting the peak power of an Ytterbium laser system from 2.5 GW to 9.1 GW. The spatial homogeneity of the output $\text{LG}_{0,l}$ beams is quantified and the topological charge is spectrally-resolved and shown to be conserved after compression by employing a custom spatio-temporal coupling measurement setup., Comment: 8 pages, 9 figures
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- 2024
14. Structural characterization of the candidate Weyl semimetal CeGaGe
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Scanlon, Liam J., Bhusal, Santosh, Hoffmann, Christina M., He, Helen, Parkin, Sean R., Arnold, Brennan J., and Gannon, William J.
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Materials Science - Abstract
Weyl semimetals have a variety of intriguing physical properties, including topologically protected electronic states that coexist with conducting states. Possible exploitation of topologically protected states in a conducting material is promising for technological applications. Weyl semimetals that form in a non-centrosymmetric structure that also contain magnetic moments may host a variety of emergent phenomena that cannot be seen in magnetic, centrosymmetric Weyl materials. It can be difficult to distinguish definitively between a centrosymmetric structure and one of its non-centrosymmetric subgroups with standard powder X-ray diffractometers in cases where two atoms in the compound have nearly the same atomic number, as is the case for the candidate Weyl semimetal CeGaGe. In these cases, a careful single-crystal neutron diffraction experiment with high-angle reflections provides complimentary information to X-ray diffraction and definitively resolves any ambiguity between centrosymmetric and non-centrosymmetric crystal structures. Single-crystal neutron diffraction measurements on the candidate Weyl semimetal CeGaGe confirms that its structure is non-centrosymmetric, described by space group 109 $\left(I4_1md\right)$ rather than the centrosymmetric space group 141 $\left(I4_1/amd\right)$. There are many high-angle reflections in the data set that give clear, physically intuitive evidence that CeGaGe forms with $I4_1md$ symmetry since Bragg planes of these reflections can contain Ga with no Ge or vice versa whereas the Bragg planes for a structure with $I4_1/amd$ symmetry would have a mix of Ga and Ge. Further, in some crystals we have studied, there is clear evidence for a structural transition from body-centered $I4_1md$ symmetry to primitive $P4_3$ and/or $P4_1$ symmetry.
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- 2024
15. Short-reach Optical Communications: A Real-world Task for Neuromorphic Hardware
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Arnold, Elias, Edelmann, Eike-Manuel, von Bank, Alexander, Müller, Eric, Schmalen, Laurent, and Schemmel, Johannes
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Computer Science - Neural and Evolutionary Computing - Abstract
Spiking neural networks (SNNs) emulated on dedicated neuromorphic accelerators promise to offer energy-efficient signal processing. However, the neuromorphic advantage over traditional algorithms still remains to be demonstrated in real-world applications. Here, we describe an intensity-modulation, direct-detection (IM/DD) task that is relevant to high-speed optical communication systems used in data centers. Compared to other machine learning-inspired benchmarks, the task offers several advantages. First, the dataset is inherently time-dependent, i.e., there is a time dimension that can be natively mapped to the dynamic evolution of SNNs. Second, small-scale SNNs can achieve the target accuracy required by technical communication standards. Third, due to the small scale and the defined target accuracy, the task facilitates the optimization for real-world aspects, such as energy efficiency, resource requirements, and system complexity.
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- 2024
16. LiDAR-based Registration against Georeferenced Models for Globally Consistent Allocentric Maps
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Quenzel, Jan, Mallwitz, Linus T., Arnold, Benedikt T., and Behnke, Sven
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Computer Science - Robotics ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Modern unmanned aerial vehicles (UAVs) are irreplaceable in search and rescue (SAR) missions to obtain a situational overview or provide closeups without endangering personnel. However, UAVs heavily rely on global navigation satellite system (GNSS) for localization which works well in open spaces, but the precision drastically degrades in the vicinity of buildings. These inaccuracies hinder aggregation of diverse data from multiple sources in a unified georeferenced frame for SAR operators. In contrast, CityGML models provide approximate building shapes with accurate georeferenced poses. Besides, LiDAR works best in the vicinity of 3D structures. Hence, we refine coarse GNSS measurements by registering LiDAR maps against CityGML and digital elevation map (DEM) models as a prior for allocentric mapping. An intuitive plausibility score selects the best hypothesis based on occupancy using a 2D height map. Afterwards, we integrate the registration results in a continuous-time spline-based pose graph optimizer with LiDAR odometry and further sensing modalities to obtain globally consistent, georeferenced trajectories and maps. We evaluate the viability of our approach on multiple flights captured at two distinct testing sites. Our method successfully reduced GNSS offset errors from up-to 16 m to below 0.5 m on multiple flights. Furthermore, we obtain globally consistent maps w.r.t. prior 3D geospatial models., Comment: Presented at IEEE International Symposium on Safety, Security, and Rescue Robotics (SSRR), New York City, USA, November 2024
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- 2024
17. MedAutoCorrect: Image-Conditioned Autocorrection in Medical Reporting
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Asiimwe, Arnold Caleb, Surís, Dídac, Rajpurkar, Pranav, and Vondrick, Carl
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Computer Science - Computer Vision and Pattern Recognition - Abstract
In medical reporting, the accuracy of radiological reports, whether generated by humans or machine learning algorithms, is critical. We tackle a new task in this paper: image-conditioned autocorrection of inaccuracies within these reports. Using the MIMIC-CXR dataset, we first intentionally introduce a diverse range of errors into reports. Subsequently, we propose a two-stage framework capable of pinpointing these errors and then making corrections, simulating an \textit{autocorrection} process. This method aims to address the shortcomings of existing automated medical reporting systems, like factual errors and incorrect conclusions, enhancing report reliability in vital healthcare applications. Importantly, our approach could serve as a guardrail, ensuring the accuracy and trustworthiness of automated report generation. Experiments on established datasets and state of the art report generation models validate this method's potential in correcting medical reporting errors.
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- 2024
18. Measuring and Forecasting Conversation Incivility: the Role of Antisocial and Prosocial Behaviors
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Yu, Xinchen, Arnold, Hayden, Su, Benjamin, and Blanco, Eduardo
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Computer Science - Computers and Society - Abstract
This paper focuses on the task of measuring and forecasting incivility in conversations following replies to hate speech. Identifying replies that steer conversations away from hatred and elicit civil follow-up conversations sheds light into effective strategies to engage with hate speech and proactively avoid further escalation. We propose new metrics that take into account various dimensions of antisocial and prosocial behaviors to measure the conversation incivility following replies to hate speech. Our best metric aligns with human perceptions better than prior work. Additionally, we present analyses on a) the language of antisocial and prosocial posts, b) the relationship between antisocial or prosocial posts and user interactions, and c) the language of replies to hate speech that elicit follow-up conversations with different incivility levels. We show that forecasting the incivility level of conversations following a reply to hate speech is a challenging task. We also present qualitative analyses to identify the most common errors made by our best model., Comment: The 19th International AAAI Conference on Web and Social Media (ICWSM 2025) Accepted
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- 2024
19. Observation of an Extraordinary Type V Solar Radio Burst: Nonlinear Evolution of the Electron Two-Stream Instability
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Benz, Arnold O., Huber, Clemens R., Timmel, Vincenzo, and Monstein, Christian
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Solar type V radio bursts are associated with type III bursts. Several processes have been proposed to interpret the association, electron distribution, and emission. We present the observation of a unique type V event observed by e-CALLISTO on 7 May 2021. The type V radio emission follows a group of U bursts. Unlike the unpolarized U bursts, the type V burst is circularly polarized, leaving room for a different emission process. Its starting edge drifts to higher frequency four times slower than the descending branch of the associated U burst. The type V processes seem to be ruled by electrons of lower energy. The observations conform to a coherent scenario where a dense electron beam drives the two-stream instability (causing type III emission) and, in the nonlinear stage, becomes unstable to another instability, previously known as the electron firehose instability (EFI). The secondary instability scatters some beam electrons into velocities perpendicular to the magnetic field and produces, after particle loss, a trapped distribution prone to electron cyclotron masering (ECM). A reduction in beaming and the formation of an isotropic halo are predicted for electron beams continuing to interplanetary space, possibly observable by Parker Solar Probe and Solar Orbiter., Comment: 12 pages, 5 figures
- Published
- 2024
- Full Text
- View/download PDF
20. Numerical analysis of a constrained strain energy minimization problem
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Aleman, Tilman and Reusken, Arnold
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Mathematics - Numerical Analysis - Abstract
We consider a setting in which an evolving surface is implicitly characterized as the zero level of a level set function. Such an implicit surface does not encode any information about the path of a single point on the evolving surface. In the literature different approaches for determining a velocity that induces corresponding paths of points on the surface have been proposed. One of these is based on minimization of the strain energy functional. This then leads to a constrained minimization problem, which has a corresponding equivalent formulation as a saddle point problem. The main topic of this paper is a detailed analysis of this saddle point problem and of a finite element discretization of this problem. We derive well-posedness results for the continuous and discrete problems and optimal error estimates for a finite element discretization that uses standard $H^1$-conforming finite element spaces., Comment: 24 pages, 9 figures
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- 2024
21. Machine learning the Ising transition: A comparison between discriminative and generative approaches
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Zhang, Difei, Schäfer, Frank, and Arnold, Julian
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Condensed Matter - Disordered Systems and Neural Networks ,Condensed Matter - Statistical Mechanics ,Computer Science - Machine Learning - Abstract
The detection of phase transitions is a central task in many-body physics. To automate this process, the task can be phrased as a classification problem. Classification problems can be approached in two fundamentally distinct ways: through either a discriminative or a generative method. In general, it is unclear which of these two approaches is most suitable for a given problem. The choice is expected to depend on factors such as the availability of system knowledge, dataset size, desired accuracy, computational resources, and other considerations. In this work, we answer the question of how one should approach the solution of phase-classification problems by performing a numerical case study on the thermal phase transition in the classical two-dimensional square-lattice ferromagnetic Ising model., Comment: 11+5 pages, 4+4 figures
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- 2024
22. 3D Wasserstein generative adversarial network with dense U-Net based discriminator for preclinical fMRI denoising
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Soltanpour, Sima, Chang, Arnold, Madularu, Dan, Kulkarni, Praveen, Ferris, Craig, and Joslin, Chris
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Functional magnetic resonance imaging (fMRI) is extensively used in clinical and preclinical settings to study brain function, however, fMRI data is inherently noisy due to physiological processes, hardware, and external noise. Denoising is one of the main preprocessing steps in any fMRI analysis pipeline. This process is challenging in preclinical data in comparison to clinical data due to variations in brain geometry, image resolution, and low signal-to-noise ratios. In this paper, we propose a structure-preserved algorithm based on a 3D Wasserstein generative adversarial network with a 3D dense U-net based discriminator called, 3D U-WGAN. We apply a 4D data configuration to effectively denoise temporal and spatial information in analyzing preclinical fMRI data. GAN-based denoising methods often utilize a discriminator to identify significant differences between denoised and noise-free images, focusing on global or local features. To refine the fMRI denoising model, our method employs a 3D dense U-Net discriminator to learn both global and local distinctions. To tackle potential over-smoothing, we introduce an adversarial loss and enhance perceptual similarity by measuring feature space distances. Experiments illustrate that 3D U-WGAN significantly improves image quality in resting-state and task preclinical fMRI data, enhancing signal-to-noise ratio without introducing excessive structural changes in existing methods. The proposed method outperforms state-of-the-art methods when applied to simulated and real data in a fMRI analysis pipeline.
- Published
- 2024
23. Towards Automated Verification of Logarithmic Arithmetic
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Arnold, Mark G., Bailey, Thomas A., and Cowles, John R.
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Computer Science - Logic in Computer Science ,Computer Science - Hardware Architecture ,B.2 - Abstract
Correctness proofs for floating point programs are difficult to verify. To simplify the task, a similar, but less complex system, known as logarithmic arithmetic can be used. The Boyer-Moore Theorem Prover, NQTHM, mechanically verified the correctness of a simple implementation of logarithmic arithmetic. It also verified some useful theorems about accumulated relative error bounds for addition, multiplication and division in this logarithmic number system. These theorems were used to verify a program that approximates e^x using a truncated Taylor series. Axioms that characterize the finite precision of the logarithmic system using a rational base, b, were shown by the prover to be satisfiable for any choice of 1 < b < 2. The prover verified the correctness of a function for converting an arbitrary rational value to a logarithmic representation. It also verified that multiplication and division implementations produce exact results for exact inputs, and that addition implementation produces a result as accurate as possible for exact inputs. When these operations are used in combination by a program, such as evaluating a polynomial, the relative error increases in a way that can be bounded by simple expressions, referred to here as tolerances. Several mechanically verified theorems about tolerances allow us to construct mechanically verified proofs about logarithmic arithmetic programs. Although similar to interval arithmetic, tolerances are especially suited to logarithmic arithmetic., Comment: 21 pages, Originally a 1994 technical report from University of Wyoming and Computational Logic, Inc
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- 2024
24. Community Research Earth Digital Intelligence Twin (CREDIT)
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Schreck, John, Sha, Yingkai, Chapman, William, Kimpara, Dhamma, Berner, Judith, McGinnis, Seth, Kazadi, Arnold, Sobhani, Negin, Kirk, Ben, and Gagne II, David John
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Computer Science - Artificial Intelligence ,Physics - Atmospheric and Oceanic Physics - Abstract
Recent advancements in artificial intelligence (AI) for numerical weather prediction (NWP) have significantly transformed atmospheric modeling. AI NWP models outperform traditional physics-based systems, such as the Integrated Forecast System (IFS), across several global metrics while requiring fewer computational resources. However, existing AI NWP models face limitations related to training datasets and timestep choices, often resulting in artifacts that reduce model performance. To address these challenges, we introduce the Community Research Earth Digital Intelligence Twin (CREDIT) framework, developed at NSF NCAR. CREDIT provides a flexible, scalable, and user-friendly platform for training and deploying AI-based atmospheric models on high-performance computing systems. It offers an end-to-end pipeline for data preprocessing, model training, and evaluation, democratizing access to advanced AI NWP capabilities. We demonstrate CREDIT's potential through WXFormer, a novel deterministic vision transformer designed to predict atmospheric states autoregressively, addressing common AI NWP issues like compounding error growth with techniques such as spectral normalization, padding, and multi-step training. Additionally, to illustrate CREDIT's flexibility and state-of-the-art model comparisons, we train the FUXI architecture within this framework. Our findings show that both FUXI and WXFormer, trained on six-hourly ERA5 hybrid sigma-pressure levels, generally outperform IFS HRES in 10-day forecasts, offering potential improvements in efficiency and forecast accuracy. CREDIT's modular design enables researchers to explore various models, datasets, and training configurations, fostering innovation within the scientific community.
- Published
- 2024
25. Explainable Search and Discovery of Visual Cultural Heritage Collections with Multimodal Large Language Models
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Arnold, Taylor and Tilton, Lauren
- Subjects
Computer Science - Computer Vision and Pattern Recognition - Abstract
Many cultural institutions have made large digitized visual collections available online, often under permissible re-use licences. Creating interfaces for exploring and searching these collections is difficult, particularly in the absence of granular metadata. In this paper, we introduce a method for using state-of-the-art multimodal large language models (LLMs) to enable an open-ended, explainable search and discovery interface for visual collections. We show how our approach can create novel clustering and recommendation systems that avoid common pitfalls of methods based directly on visual embeddings. Of particular interest is the ability to offer concrete textual explanations of each recommendation without the need to preselect the features of interest. Together, these features can create a digital interface that is more open-ended and flexible while also being better suited to addressing privacy and ethical concerns. Through a case study using a collection of documentary photographs, we provide several metrics showing the efficacy and possibilities of our approach., Comment: 16 pages, CHR 2024: Computational Humanities Research Conference, December 4 - 6, 2024, Aarhus University, Denmark
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- 2024
26. Automated Image Color Mapping for a Historic Photographic Collection
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Arnold, Taylor and Tilton, Lauren
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Computer Science - Computer Vision and Pattern Recognition ,Statistics - Applications - Abstract
In the 1970s, the United States Environmental Protection Agency sponsored Documerica, a large-scale photography initiative to document environmental subjects nation-wide. While over 15,000 digitized public-domain photographs from the collection are available online, most of the images were scanned from damaged copies of the original prints. We present and evaluate a modified histogram matching technique based on the underlying chemistry of the prints for correcting the damaged images by using training data collected from a small set of undamaged prints. The entire set of color-adjusted Documerica images is made available in an open repository., Comment: 11 pages, CHR 2024: Computational Humanities Research Conference, December 4 - 6, 2024, Aarhus University, Denmark
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- 2024
27. Multivariate Data Augmentation for Predictive Maintenance using Diffusion
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Thompson, Andrew, Sommers, Alexander, Russell-Gilbert, Alicia, Cummins, Logan, Mittal, Sudip, Rahimi, Shahram, Seale, Maria, Jaboure, Joseph, Arnold, Thomas, and Church, Joshua
- Subjects
Computer Science - Machine Learning - Abstract
Predictive maintenance has been used to optimize system repairs in the industrial, medical, and financial domains. This technique relies on the consistent ability to detect and predict anomalies in critical systems. AI models have been trained to detect system faults, improving predictive maintenance efficiency. Typically there is a lack of fault data to train these models, due to organizations working to keep fault occurrences and down time to a minimum. For newly installed systems, no fault data exists since they have yet to fail. By using diffusion models for synthetic data generation, the complex training datasets for these predictive models can be supplemented with high level synthetic fault data to improve their performance in anomaly detection. By learning the relationship between healthy and faulty data in similar systems, a diffusion model can attempt to apply that relationship to healthy data of a newly installed system that has no fault data. The diffusion model would then be able to generate useful fault data for the new system, and enable predictive models to be trained for predictive maintenance. The following paper demonstrates a system for generating useful, multivariate synthetic data for predictive maintenance, and how it can be applied to systems that have yet to fail.
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- 2024
28. AAD-LLM: Adaptive Anomaly Detection Using Large Language Models
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Russell-Gilbert, Alicia, Sommers, Alexander, Thompson, Andrew, Cummins, Logan, Mittal, Sudip, Rahimi, Shahram, Seale, Maria, Jaboure, Joseph, Arnold, Thomas, and Church, Joshua
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Computational Engineering, Finance, and Science - Abstract
For data-constrained, complex and dynamic industrial environments, there is a critical need for transferable and multimodal methodologies to enhance anomaly detection and therefore, prevent costs associated with system failures. Typically, traditional PdM approaches are not transferable or multimodal. This work examines the use of Large Language Models (LLMs) for anomaly detection in complex and dynamic manufacturing systems. The research aims to improve the transferability of anomaly detection models by leveraging Large Language Models (LLMs) and seeks to validate the enhanced effectiveness of the proposed approach in data-sparse industrial applications. The research also seeks to enable more collaborative decision-making between the model and plant operators by allowing for the enriching of input series data with semantics. Additionally, the research aims to address the issue of concept drift in dynamic industrial settings by integrating an adaptability mechanism. The literature review examines the latest developments in LLM time series tasks alongside associated adaptive anomaly detection methods to establish a robust theoretical framework for the proposed architecture. This paper presents a novel model framework (AAD-LLM) that doesn't require any training or finetuning on the dataset it is applied to and is multimodal. Results suggest that anomaly detection can be converted into a "language" task to deliver effective, context-aware detection in data-constrained industrial applications. This work, therefore, contributes significantly to advancements in anomaly detection methodologies.
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- 2024
29. Parent Engagement in Child-Focused Interventions: A Systematised Review of Qualitative Allied Health Literature
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Victoria Burney, Clare M. McCann, and Angela Arnold-Saritepe
- Abstract
Background: Parent engagement in child-focused interventions is increasingly recognised as an important aspect of effective intervention delivery. While several fields have an emerging literature around parent engagement, no reviews currently exist which combine findings across allied health literatures. Objective: This review aimed to explore factors relevant to understanding parent engagement in child-focused interventions, as described in qualitative literature across allied health disciplines, toward informing the clinical practice of helping professionals in effectively engaging parents. Methods: A systematised qualitative literature review was carried out, with a comprehensive search of five online databases (CINAHL, Embase, MEDLINE, PsycINFO, Scopus) for allied health literature (specifically: behaviour analysis, occupational therapy, psychology, and speech-language therapy) using parent engagement key words. Reference searching and citation tracking steps supported the search. Thematic synthesis was used as the overarching framework and analysis approach. Results: 8824 unique studies were generated in the search. Of the 71 studies which met inclusion criteria, 38 reported qualitative findings and were included in the analysis. Five themes were identified including: societal context, interpersonal context, clinician features, family features, and relationship as engagement. Conclusions: Findings support conceptual explanations of parent engagement as a complex and dynamic process, emphasising the joint contributions of parents and clinicians in developing therapeutic relationships which promote engagement. Across allied health research there are consistency of understandings around parent engagement, supporting the conclusion that clinicians can look to literatures from various helping fields to inform clinical practice around engaging parents in interventions.
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- 2024
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30. From Fragmentation to Coherence: Student Experience of Assessment for Learning
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Julie Arnold and Jill Willis
- Abstract
Student experience of Assessment for Learning (AfL) pedagogies ideally provides multiple entry points for students to take past learning forward into future learning. In practice, points of disconnection may confound the accessibility of AfL's repertoire of practices. This paper investigates the AfL experiences of students with likely language and attentional difficulties and their peers in three Australian secondary schools. Ninety-two students shared their insights in interviews and focus groups, with data analysed abductively through a conceptual frame of six dimensions. Common practical effects for students included recognition and value of a range of teacher practices. Students with language and attentional difficulties indicated more uneven recall of processes, especially when teacher practice of AfL was fragmented and classroom routines prioritised summative assessment. Fragmentation in turn compromised the emotional and evaluative dimensions of experience that catalyse continuity in learning. Critical insights from students about how they searched for and secured cohesive experiences points to how AfL offers agentic possibilities for learning beyond the immediate activities of the classroom.
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- 2024
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31. For better or worse
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WHITTALL, ARNOLD
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- 2024
32. Increasing adherence and collecting symptom-specific biometric signals in remote monitoring of heart failure patients: a randomized controlled trial.
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Mohapatra, Sukanya, Issa, Mirna, Ivezic, Vedrana, Doherty, Rose, Marks, Stephanie, Lan, Esther, Chen, Shawn, Rozett, Keith, Cullen, Lauren, Reynolds, Wren, Rocchio, Rose, Fonarow, Gregg, Ong, Michael, Speier, William, and Arnold, Corey
- Subjects
heart failure ,mHealth ,remote monitoring ,Humans ,Heart Failure ,Mobile Applications ,Male ,Telemedicine ,Female ,Middle Aged ,Patient Compliance ,Aged ,Prospective Studies ,Motivation ,Fitness Trackers - Abstract
OBJECTIVES: Mobile health (mHealth) regimens can improve health through the continuous monitoring of biometric parameters paired with appropriate interventions. However, adherence to monitoring tends to decay over time. Our randomized controlled trial sought to determine: (1) if a mobile app with gamification and financial incentives significantly increases adherence to mHealth monitoring in a population of heart failure patients; and (2) if activity data correlate with disease-specific symptoms. MATERIALS AND METHODS: We recruited individuals with heart failure into a prospective 180-day monitoring study with 3 arms. All 3 arms included monitoring with a connected weight scale and an activity tracker. The second arm included an additional mobile app with gamification, and the third arm included the mobile app and a financial incentive awarded based on adherence to mobile monitoring. RESULTS: We recruited 111 heart failure patients into the study. We found that the arm including the financial incentive led to significantly higher adherence to activity tracker (95% vs 72.2%, P = .01) and weight (87.5% vs 69.4%, P = .002) monitoring compared to the arm that included the monitoring devices alone. Furthermore, we found a significant correlation between daily steps and daily symptom severity. DISCUSSION AND CONCLUSION: Our findings indicate that mobile apps with added engagement features can be useful tools for improving adherence over time and may thus increase the impact of mHealth-driven interventions. Additionally, activity tracker data can provide passive monitoring of disease burden that may be used to predict future events.
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- 2025
33. Association between immunosuppressive medications and COVID-19 hospitalisation and death: a retrospective cohort study.
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Sechrist, Samantha, Tang, Emily, Arnold, Benjamin, and Acharya, Nisha
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COVID-19 ,EPIDEMIOLOGIC STUDIES ,Epidemiology ,Public health ,Rheumatology ,Humans ,COVID-19 ,Male ,Retrospective Studies ,Female ,Middle Aged ,Hospitalization ,Immunosuppressive Agents ,Aged ,SARS-CoV-2 ,Adult ,Adrenal Cortex Hormones ,Immunocompromised Host ,Risk Factors ,Antirheumatic Agents ,COVID-19 Drug Treatment - Abstract
IMPORTANCE: Immunocompromised status is a risk factor for severe SARS-CoV-2 infection. Little is known about how systemic corticosteroid dose and concurrent use of immunosuppressants are associated with COVID-19 outcomes. OBJECTIVE: To assess the association between corticosteroid dose/duration and concurrent immunosuppressant use on COVID-19 hospitalisation and death in the era of COVID-19 vaccinations. DESIGN: This is a retrospective cohort study using a deidentified insurance claims database from 1 July 2020 to 30 June 30, 2022, with the risk period starting on 1 July 2021. Impact of corticosteroid exposures and concurrent use of other immunosuppressants was assessed with attributable risk analysis and Cox regression that included COVID-19 vaccination status and time-updated dichotomous immunosuppressive medication exposures. PARTICIPANTS: There were 10 109 596 eligible patients enrolled during the risk period, each with at least 365 days of continuous enrolment prior to 1 July 2021. EXPOSURES: Systemic corticosteroids, disease-modifying antirheumatic drugs (DMARDs), tumour necrosis factor-alpha inhibitors (TNFis) and other immunosuppressive drug categories. MAIN OUTCOMES: Incidence rate ratios and hazard ratios for COVID-19 hospitalisation and death. RESULTS: Corticosteroids were prescribed to 1 379 049 (13.6%) of 10 109 596 individuals. After adjustment, corticosteroids were associated with an increased risk of COVID-19 hospitalisation (HR: 5.40; 95% CI 5.27 to 5.53; p
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- 2024
34. Stabilization of reactive rare earth alkyl complexes through mechanistic studies
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Tanuhadi, Elias, Bair, Anna S, Johnson, Mary, Fontaine, Philip, Klosin, Jerzy, Pal, Sudipta, and Arnold, Polly L
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Inorganic Chemistry ,Chemical Sciences ,Chemical sciences - Abstract
Rare earth tris(alkyl) complexes such as M(CH2SiMe3)3(sol) n are widely used as precursors for many compounds and as homogeneous catalysts for alkene polymerization and alkane functionalization. However, the thermal instability of those most conveniently made from the commercially available lithium salt of the neosilyl anion, LiCH2SiMe3, Li(r), restricts their utility. We present a new range of synthetically useful, more kinetically stable rare earth neosilyl solvates, derived from a full kinetic study of the various possible decomposition mechanisms of 7 known and 12 new solvated rare earth neosilyl complexes M(CH2SiMe3)3(sol) n M = Sc(iii), Y(iii), Lu(iii), Sm(iii), and sol = THF; TMEDA; DMPE; diglyme ((CH3)2(OCH2CH2)2O, G2), triglyme ((CH3)2(OCH2CH2)3O, G3). Surprisingly, simply using higher-denticity donors to sterically disfavor neosilyl γ-H elimination is not effective. While Sc(r)3((CH3)2(OCH2CH2)2O) has a half-life, t 1/2, of 258.1 h, six times longer than for Sc(r)3(C4H8O)2 (t 1/2 = 43 h), Lu(r)3((CH3)2(OCH2CH2)2O) and Y(r)3((CH3)2(OCH2CH2)2O) do not show the expected, analogous increased t 1/2. This is because new decomposition pathways appear for poorly fitting donors. Finally, kinetic studies demonstrate the impact of small, and increasing amounts of LiCl on the kinetics of the reactivity of the smaller alkyls Y(r)3(THF)2 and Lu(r)3(THF)2; molecules used in hydrocarbon chemistry and catalysis for fifty years. A new route to pure Y(r)3(THF)2, which avoids the traditional use of Li(r), is presented.
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- 2024
35. A temperature-sensitive and less immunogenic Sendai virus for efficient gene editing.
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Stevens, Christian, Carmichael, Jillian, Watkinson, Ruth, Kowdle, Shreyas, Reis, Rebecca, Hamane, Kory, Jang, Jason, Park, Arnold, Pernet, Olivier, Khamaikawin, Wannisa, Hong, Patrick, Thibault, Patricia, Gowlikar, Aditya, An, Dong, and Lee, Benhur
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CCR5 ,CRISPR/Cas9 ,HIV ,Paramyxoviridae ,Sendai virus ,gene editing ,hematopoietic stem and progenitor cells ,monocytes ,viral vector ,Gene Editing ,Humans ,Sendai virus ,Receptors ,CCR5 ,Hematopoietic Stem Cells ,Genetic Vectors ,CRISPR-Cas Systems ,Temperature ,HIV-1 ,Transduction ,Genetic ,HIV Infections ,Monocytes - Abstract
UNLABELLED: The therapeutic potential of gene editing technologies hinges on the development of safe and effective delivery methods. In this study, we developed a temperature-sensitive and less immunogenic Sendai virus (ts SeV) as a novel delivery vector for CRISPR-Cas9 and for efficient gene editing in sensitive human cell types with limited induction of an innate immune response. ts SeV demonstrates high transduction efficiency in human CD34+ hematopoietic stem and progenitor cells (HSPCs) including transduction of the CD34+/CD38-/CD45RA-/CD90+(Thy1+)/CD49fhigh stem cell enriched subpopulation. The frequency of CCR5 editing exceeded 90% and bi-allelic CCR5 editing exceeded 70% resulting in significant inhibition of HIV-1 infection in primary human CD14+ monocytes. These results demonstrate the potential of the ts SeV platform as a safe, efficient, and flexible addition to the current gene-editing tool delivery methods, which may help further expand the possibilities in personalized medicine and the treatment of genetic disorders. IMPORTANCE: Gene editing has the potential to be a powerful tool for the treatment of human diseases including HIV, β-thalassemias, and sickle cell disease. Recent advances have begun to overcome one of the major limiting factors of this technology, namely delivery of the CRISPR-Cas9 gene editing machinery, by utilizing viral vectors. However, gene editing therapies have yet to be implemented due to inherent risks associated with the DNA viral vectors typically used for delivery. As an alternative strategy, we have developed an RNA-based Sendai virus CRISPR-Cas9 delivery vector that does not integrate into the genome, is temperature sensitive, and does not induce a significant host interferon response. This recombinant SeV successfully delivered CRISPR-Cas9 in primary human CD14+ monocytes ex vivo resulting in a high level of CCR5 editing and inhibition of HIV infection.
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- 2024
36. Lipid Membrane Domains Control Actin Network Viscoelasticity.
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Arnold, Daniel and Takatori, Sho
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Viscosity ,Elasticity ,Actins ,Membrane Microdomains - Abstract
The mammalian cell membrane is embedded with biomolecular condensates of protein and lipid clusters, which interact with an underlying viscoelastic cytoskeleton network to organize the cell surface and mechanically interact with the extracellular environment. However, the mechanical and thermodynamic interplay between the viscoelastic network and liquid-liquid phase separation of 2-dimensional (2D) lipid condensates remains poorly understood. Here, we engineer materials composed of 2D lipid membrane condensates embedded within a thin viscoelastic actin network. The network generates localized anisotropic stresses that deform lipid condensates into triangular morphologies with sharp edges and corners, shapes unseen in many 3D composite gels. Kinetic coarsening of phase-separating lipid condensates accelerates the viscoelastic relaxation of the network, leading to an effectively softer composite material over intermediate time scales. We dynamically manipulate the membrane composition to control the elastic-to-viscous crossover of the network. Such viscoelastic composite membranes may enable the development of coatings, catalytic surfaces, separation membranes, and other interfaces with tunable spatial organization and plasticity mechanisms.
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- 2024
37. Cause-Specific Mortality among Infants in a Randomized Controlled Trial of Azithromycin Compared to Placebo for Prevention of Mortality.
- Author
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Ouattara, Mamadou, Sié, Ali, Bountogo, Mamadou, Boudo, Valentin, Ouedraogo, Thierry, Dah, Clarisse, Lebas, Elodie, Hu, Huiyu, Lansdale, Aimee, Fetterman, Ian, Arnold, Benjamin, Lietman, Thomas, and Oldenburg, Catherine
- Subjects
Humans ,Azithromycin ,Infant ,Infant Mortality ,Anti-Bacterial Agents ,Burkina Faso ,Cause of Death ,Female ,Male ,Respiratory Tract Infections ,Infant ,Newborn ,Malaria - Abstract
Although community randomized trials have found a reduction in all-cause child mortality in communities receiving mass azithromycin distribution compared with placebo, individually randomized trials have not found similar protective effects. If a direct effect of azithromycin for prevention of child mortality exists, it is likely due to reduction in infectious mortality. Here, we assessed cause-specific mortality in a large randomized controlled trial of azithromycin administered during well-infant visits in Burkina Faso for prevention of mortality. Among 32,877 enrolled infants, the most common causes of death by 6 months of age were malaria, acute respiratory infections, and diarrheal disease. We found no evidence of a difference in the distribution of cause of death by randomized treatment assignment (P = 0.42) or in any infectious-specific cause of death. The results of this analysis are consistent with no direct effect of azithromycin on infant mortality when administered during well-infant visits.
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- 2024
38. Impact of Small-Quantity Lipid-Based Nutrient Supplements on Pubertal Status of 9-13-Year Olds: A Follow-Up Study of the iLiNS-DYAD-Ghana Trial.
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Nti, Helena, Adu-Afarwuah, Seth, Oaks, Brietta, Prado, Elizabeth, Arnold, Charles, Hastings, Paul, Guyer, Amanda, Dewey, Kathryn, Amponsah, Benjamin, Bentil, Helena, Mensah, Mavis, Adjetey, Ebenezer, Tan, Xiuping, Aryee, Lois, Labi, Fatimah, and Manu, Adom
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Ghana ,SQ-LNS ,adolescents ,birth weight ,first 1000 d ,pubertal development - Abstract
BACKGROUND: Early and delayed puberty are both associated with adverse health and psychosocial outcomes. OBJECTIVES: We assessed the impact of provision of small-quantity lipid-based nutrient supplement (SQ-LNS) to mothers during pregnancy and 6 mo postpartum and to their children aged 6-18 mo, on pubertal status. METHODS: This study was a follow-up to a partially double-blind randomized controlled trial. At ≤20 wk, 1320 females were randomly assigned to receive daily: iron and folic acid during pregnancy and placebo 0-6 mo postpartum; or multiple micronutrients during pregnancy and 0-6 mo postpartum; or SQ-LNS during pregnancy and 0-6 mo postpartum and to their children from 6 to 18 mo. We re-enrolled 966 and 919 children at 9-11 y and 11-13 y, respectively. We calculated a total pubertal status score based on the Petersen Pubertal Development Scale (PDS) to assess growth spurt, skin changes, body hair, facial hair, voice break, breast development, and menstruation. Pubertal status was regressed on childs age to generate age-adjusted PDS z-scores (aPDSZ); we performed interaction and mediation analyses. RESULTS: Mean ± standard deviation aPDSZ did not differ between the SQ-LNS and non-LNS groups at 9-11 y (0.01 ± 0.95 compared with -0.01 ± 0.98; P = 0.958) but was more advanced in the SQ-LNS group at 11-13 y (0.07 ± 1.04 compared with -0.04 ± 0.98; P = 0.049) in the adjusted model. The effect of SQ-LNS varied by sex (P-interaction = 0.003) and household asset index z-score (P-interaction = 0.002): Puberty was more advanced in the SQ-LNS compared with non-LNS group among females (P = 0.007) but not males (P = 0.877), and within lower (P = 0.002) than average (P = 0.436) and higher (P = 0.332) socioeconomic households. CONCLUSION: Provision of SQ-LNS during the first 1000 d of life advanced pubertal status among females. TRIAL REGISTRATION NUMBER: This trial was registered at clinicaltrials.gov as NCT00970866 (https://clinicaltrials.gov/ct2/show/record/NCT00970866).
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- 2024
39. Understanding the Effectiveness of Water, Sanitation, and Hygiene Interventions: A Counterfactual Simulation Approach to Generalizing the Outcomes of Intervention Trials.
- Author
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Brouwer, Andrew, Zahid, Mondal, Eisenberg, Marisa, Arnold, Benjamin, Ashraf, Sania, Benjamin-Chung, Jade, Colford, John, Ercumen, Ayse, Luby, Stephen, Pickering, Amy, Rahman, Mahbubur, Kraay, Alicia, Eisenberg, Joseph, and Freeman, Matthew
- Subjects
Sanitation ,Humans ,Bangladesh ,Hygiene ,Diarrhea ,Child ,Preschool ,Infant ,Water Supply ,Bayes Theorem ,Female ,Male - Abstract
BACKGROUND: While water, sanitation, and hygiene (WASH) interventions can reduce diarrheal disease, many large-scale trials have not found the expected health gains for young children in low-resource settings. Evidence-based guidance is needed to improve interventions and remove barriers to diarrheal disease reduction. OBJECTIVES: We aimed to estimate how sensitive WASH intervention effectiveness was to underlying contextual and intervention factors in the WASH Benefits (WASH-B) Bangladesh cluster-randomized controlled trial. METHODS: The investigators measured diarrheal prevalence in children enrolled in the WASH-B trial at three time points approximately 1 year apart (n=17,187 observations). We developed a susceptible-infectious-susceptible model with transmission across multiple environmental pathways and evaluated each of four interventions [water (W), sanitation (S), hygiene (H), and nutrition (N) applied individually and in combination], compliance with interventions, and the impact of individuals not enrolled in the study. Leveraging a set of mechanistic parameter combinations fit to the WASH-B Bangladesh trial using a hybrid Bayesian sampling-importance resampling and maximum-likelihood estimation approach, we simulated trial outcomes under counterfactual scenarios to estimate how changes in six WASH factors (preexisting WASH conditions, disease transmission potential, intervention compliance, intervenable fraction of transmission, intervention efficacy, and community coverage) impacted intervention effectiveness. RESULTS: Increasing community coverage had the greatest impact on intervention effectiveness (e.g., median increases in effectiveness of 34.0 and 45.5 percentage points in the WSH and WSHN intervention arms when increasing coverage to 20%). The effect of community coverage on effectiveness depended on how much transmission was along pathways not modified by the interventions. Intervention effectiveness was reduced by lower levels of preexisting WASH conditions or increased baseline disease burden. Individual interventions had complementary but not synergistic effects when combined. DISCUSSION: To realize the expected health gains, future WASH interventions must address community coverage and transmission along pathways not traditionally covered by WASH. The effectiveness of individual-level WASH improvements is reduced more the further the community is from achieving the coverage needed for herd protection. https://doi.org/10.1289/EHP15200.
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- 2024
40. Seroepidemiology of trachoma in a low prevalence region receiving annual mass azithromycin distribution in Maradi, Niger.
- Author
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Amza, Abdou, Kadri, Boubacar, Nassirou, Beido, Arzika, Ahmed, Gebreegziabher, Elisabeth, Hu, Huiyu, Zhong, Lina, Chen, Cindi, Yu, Danny, Abraham, Thomas, Liu, YuHeng, Wickens, Karana, Doan, Thuy, Martin, Diana, Arnold, Benjamin, Lietman, Thomas, and Oldenburg, Catherine
- Subjects
Humans ,Chlamydia trachomatis ,Trachoma ,Azithromycin ,Bacterial Proteins ,Immunoglobulin G ,Antibodies ,Bacterial ,Antigens ,Bacterial ,Anti-Bacterial Agents ,Prevalence ,Seroepidemiologic Studies ,Child ,Child ,Preschool ,Infant ,Niger ,Female ,Male ,Mass Drug Administration - Abstract
BackgroundTrachoma programs use the indicator trachomatous inflammation--follicular (TF) to monitor indication for and response to treatment for trachoma at the district level. Alternative indicators, including serologic markers, are increasingly being evaluated for trachoma surveillance. We evaluated seroprevalence of IgG antibodies to the Pgp3 antigen in two districts in Maradi, Niger thought to have low TF prevalence.MethodsData were collected as part of the baseline assessment of the Azithromycin Reduction to Reach Elimination of Trachoma (ARRET) trial in September 2021. A random sample of 80 communities was selected from Mayahi and Guidan Roumdji districts, both of which had TF prevalence
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- 2024
41. Spatial resolution enhancement using deep learning improves chest disease diagnosis based on thick slice CT.
- Author
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Yu, Pengxin, Zhang, Haoyue, Wang, Dawei, Zhang, Rongguo, Deng, Mei, Yang, Haoyu, Wu, Lijun, Liu, Xiaoxu, Oh, Andrea, Abtin, Fereidoun, Prosper, Ashley, Ruchalski, Kathleen, Wang, Nana, Zhang, Huairong, Li, Ye, Lv, Xinna, Liu, Min, Zhao, Shaohong, Li, Dasheng, Hoffman, John, Aberle, Denise, Liang, Chaoyang, Qi, Shouliang, and Arnold, Corey
- Abstract
CT is crucial for diagnosing chest diseases, with image quality affected by spatial resolution. Thick-slice CT remains prevalent in practice due to cost considerations, yet its coarse spatial resolution may hinder accurate diagnoses. Our multicenter study develops a deep learning synthetic model with Convolutional-Transformer hybrid encoder-decoder architecture for generating thin-slice CT from thick-slice CT on a single center (1576 participants) and access the synthetic CT on three cross-regional centers (1228 participants). The qualitative image quality of synthetic and real thin-slice CT is comparable (p = 0.16). Four radiologists accuracy in diagnosing community-acquired pneumonia using synthetic thin-slice CT surpasses thick-slice CT (p 0.99). For lung nodule detection, sensitivity with thin-slice CT outperforms thick-slice CT (p 0.05). These findings indicate the potential of our model to generate high-quality synthetic thin-slice CT as a practical alternative when real thin-slice CT is preferred but unavailable.
- Published
- 2024
42. Infant diet quality index predicts nutrients of concern and ultra-processed food intake in low-income children in the United States.
- Author
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Chaney, Alana, Arnold, Charles, Frongillo, Edward, Ritchie, Lorrene, Steele, Euridice, and Au, Lauren
- Subjects
Complementary feeding ,Infant diet ,Ultra-processed foods ,children ,toddlers - Abstract
BACKGROUND: Diet quality during infancy can influence nutrient intake and ultra-processed foods (UPFs) consumption throughout later childhood. OBJECTIVES: This study investigated the predictive validity of Infant Diet Quality Index (IDQI) scores from 0 to 1 y of age and consumption of select nutrients and UPFs at different time points in low-income children aged 2-5 y. METHODS: Dietary surveys and 24-h dietary recalls collected between ages 0 and 12 months from 2613 Special Supplemental Women, Infants, and Children Infant Toddler Feeding Practices Study-2 participants were used to assess infant diet quality by final IDQI score ranging from 0 (nonadherence to dietary guidelines) to 1 (complete adherence to guidelines). Single 24-h recalls collected across multiple time points per child aged between 2 and 5 y were used to determine nutrient intakes: vitamin B12 (μg), vitamin D (μg), calcium (mg), iron (mg), zinc (mg), potassium (mg), saturated fat (g), dietary fiber (g), and added sugars (g). Likewise, Nova was used to classify foods (to estimate the percentage of energy from foods) by level of industrial processing at each point in time across ages 2-5 y. Survey-weighted regression analyses estimated associations between total IDQI score and nutrient intake and percentage of energy consumption from each Nova food group at each age between 2-5 y. RESULTS: IDQI scores based on diet quality from 0-1 y of age were positively associated with childrens dietary fiber and potassium intake at ages 2-5 y. Additionally, IDQI was negatively associated with added sugar intake. No associations were observed between IDQI and saturated fat consumption. IDQI scores at age 1 were positively associated with the percentage of energy attributed to unprocessed/minimally processed foods (20%-23%) and negatively associated with UPF consumption at ages 2-5 y (-24% to -29%). CONCLUSIONS: IDQI predicts intake of select nutrients and UPF consumption among low-income US children aged 2-5 y.This trial was registered at https://clinicaltrials.gov/study/NCT02031978 as Feeding My Baby - A National WIC Study, NCT02031978.
- Published
- 2024
43. A framework for translating tauopathy therapeutics: Drug discovery to clinical trials
- Author
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Feldman, Howard H, Cummings, Jeffrey L, Boxer, Adam L, Staffaroni, Adam M, Knopman, David S, Rizzo, Stacey J Sukoff, Territo, Paul R, Arnold, Steven E, Ballard, Clive, Beher, Dirk, Boeve, Bradley F, Dacks, Penny A, Diaz, Kristophe, Ewen, Colin, Fiske, Brian, Gonzalez, M Isabel, Harris, Glenn A, Hoffman, Beth J, Martinez, Terina N, McDade, Eric, Nisenbaum, Laura K, Palma, Jose‐Alberto, Quintana, Melanie, Rabinovici, Gil D, Rohrer, Jonathan D, Rosen, Howard J, Troyer, Matthew D, Kim, Doo Yeon, Tanzi, Rudolph E, Zetterberg, Henrik, Ziogas, Nick K, May, Patrick C, and Rommel, Amy
- Subjects
Biomedical and Clinical Sciences ,Biological Psychology ,Clinical Sciences ,Neurosciences ,Psychology ,Acquired Cognitive Impairment ,Frontotemporal Dementia (FTD) ,Aging ,Rare Diseases ,Alzheimer's Disease ,Dementia ,Neurodegenerative ,Brain Disorders ,Clinical Research ,Orphan Drug ,Alzheimer's Disease Related Dementias (ADRD) ,Clinical Trials and Supportive Activities ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,5.1 Pharmaceuticals ,Neurological ,Humans ,Tauopathies ,Drug Discovery ,Clinical Trials as Topic ,Biomarkers ,Translational Research ,Biomedical ,tau Proteins ,Drug Development ,biomarkers ,development ,early-phase clinical trials ,preclinical ,tauopathy ,therapeutics ,early‐phase clinical trials ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
The tauopathies are defined by pathological tau protein aggregates within a spectrum of clinically heterogeneous neurodegenerative diseases. The primary tauopathies meet the definition of rare diseases in the United States. There is no approved treatment for primary tauopathies. In this context, designing the most efficient development programs to translate promising targets and treatments from preclinical studies to early-phase clinical trials is vital. In September 2022, the Rainwater Charitable Foundation convened an international expert workshop focused on the translation of tauopathy therapeutics through early-phase trials. Our report on the workshop recommends a framework for principled drug development and a companion lexicon to facilitate communication focusing on reproducibility and achieving common elements. Topics include the selection of targets, drugs, biomarkers, participants, and study designs. The maturation of pharmacodynamic biomarkers to demonstrate target engagement and surrogate disease biomarkers is a crucial unmet need. HIGHLIGHTS: Experts provided a framework to translate therapeutics (discovery to clinical trials). Experts focused on the "5 Rights" (target, drug, biomarker, participants, trial). Current research on frontotemporal degeneration, progressive supranuclear palsy, and corticobasal syndrome therapeutics includes 32 trials (37% on biologics) Tau therapeutics are being tested in Alzheimer's disease; primary tauopathies have a large unmet need.
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- 2024
44. Integrating community health workers into HIV care clinics: a qualitative study with health system leaders and clinicians in the Southern United States.
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Fuller, Shannon, Arnold, Emily, Xavier, Jessica, Ibe, Chidinma, Steward, Wayne, Myers, Janet, Rebchook, Greg, and Koester, Kimberly
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Care integration ,Community health workers ,HIV ,Qualitative research ,Humans ,HIV Infections ,Community Health Workers ,Qualitative Research ,Mississippi ,Interviews as Topic ,Male ,Female ,Ambulatory Care Facilities ,Louisiana ,Capacity Building ,Leadership - Abstract
BACKGROUND: Community health workers (CHWs) can support patient engagement in care for a variety of health conditions, including HIV. This paper reports on the experiences of HIV clinics and health departments that integrated CHWs into their health systems as part of a capacity-building initiative to address HIV-related disparities in the United States. METHODS: Semi-structured interviews were conducted with key informants (n = 14) in two Ryan White HIV/AIDS program jurisdictions: Mississippi (jurisdiction covers the entire state) and the city of New Orleans, Louisiana. This work was part of a larger evaluation of an initiative that used a Learning Collaborative model to facilitate the implementation of evidence-informed interventions to address HIV care continuum gaps in four jurisdictions. The two jurisdictions that focused on integrating CHWs into HIV care clinics and support service agencies were selected for this sub-analysis. Interview participants included HIV clinic leaders and staff, health department leaders, and other Learning Collaborative leaders. Interview transcripts were coded and analyzed for themes related to the acceptability, feasibility, and perceived impact of CHW integration. RESULTS: Overall, participants expressed interest in having support from CHWs at HIV clinics and service agencies to assist with patient retention and engagement efforts. However, there were challenges integrating CHWs into existing systems (e.g., gaining access to electronic health records, changing policies to conduct home visits, and clarifying roles and scope of work). Negotiating contracts and accessing funding for CHW positions presented major challenges that often contributed to turnover and conflicts around scope of practice. When health departments leveraged existing funding streams to support CHW positions, the clinics and agencies where the CHWs worked had limited flexibility over the hiring process. CONCLUSIONS: Our findings reinforce the value and acceptability of CHWs as part of the workforce in HIV clinical and support service settings; however, integrating CHWs into clinics and service agencies required effort. Training the CHWs was not sufficient; other staff and clinicians had to understand the role of CHWs to facilitate their integration into health systems. Resources are needed to support organizations in incorporating CHWs effectively, and long-term, flexible sources of funding are necessary for these positions.
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- 2024
45. Comparison of Diagnosis Codes to Clinical Notes in Classifying Patients with Diabetic Retinopathy
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Yonamine, Sean, Jian, Chu, Alabi, Rolake O, Kaidonis, Georgia, Chan, Lawrence, Borkar, Durga, Stein, Joshua D, Arnold, Benjamin F, and Sun, Catherine Q
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Clinical Trials and Supportive Activities ,Diabetes ,Machine Learning and Artificial Intelligence ,Clinical Research ,Networking and Information Technology R&D (NITRD) ,4.2 Evaluation of markers and technologies ,Clinical notes ,Diabetic retinopathy ,ICD-9 ,ICD-10 ,Natural language ,Natural language processing - Abstract
PurposeElectronic health records (EHRs) contain a vast amount of clinical data. Improved automated classification approaches have the potential to accurately and efficiently identify patient cohorts for research. We evaluated if a rule-based natural language processing (NLP) algorithm using clinical notes performed better for classifying proliferative diabetic retinopathy (PDR) and nonproliferative diabetic retinopathy (NPDR) severity compared with International Classification of Diseases, ninth edition (ICD-9) or 10th edition (ICD-10) codes.DesignCross-sectional study.SubjectsDeidentified EHR data from an academic medical center identified 2366 patients aged ≥18 years, with diabetes mellitus, diabetic retinopathy (DR), and available clinical notes.MethodsFrom these 2366 patients, 306 random patients (100 training set, 206 test set) underwent chart review by ophthalmologists to establish the gold standard. International Classification of Diseases codes were extracted from the EHR. The notes algorithm identified positive mention of PDR and NPDR severity from clinical notes. Proliferative diabetic retinopathy and NPDR severity classification by ICD codes and the notes algorithm were compared with the gold standard. The entire DR cohort (N = 2366) was then classified as having presence (or absence) of PDR using ICD codes and the notes algorithm.Main outcome measuresSensitivity, specificity, positive predictive value (PPV), negative predictive value, and F1 score for the notes algorithm compared with ICD codes using a gold standard of chart review.ResultsFor PDR classification of the test set patients, the notes algorithm performed better than ICD codes for all metrics. Specifically, the notes algorithm had significantly higher sensitivity (90.5% [95% confidence interval 85.7, 94.9] vs. 68.4% [60.4, 75.3]), but similar PPV (98.0% [95.4-100] vs. 94.7% [90.3, 98.3]) respectively. The F1 score was 0.941 [0.910, 0.966] for the notes algorithm compared with 0.794 [0.734, 0.842] for ICD codes. For PDR classification, ICD-10 codes performed better than ICD-9 codes (F1 score 0.836 [0.771, 0.878] vs. 0.596 [0.222, 0.692]). For NPDR severity classification, the notes algorithm performed similarly to ICD codes, but performance was limited by small sample size.ConclusionsThe notes algorithm outperformed ICD codes for PDR classification. The findings demonstrate the significant potential of applying a rule-based NLP algorithm to clinical notes to increase the efficiency and accuracy of cohort selection for research.Financial disclosuresProprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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- 2024
46. Effects of prenatal small-quantity lipid-based nutrient supplements on pregnancy, birth, and infant outcomes: a systematic review and meta-analysis of individual participant data from randomized controlled trials in low- and middle-income countries.
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Dewey, Kathryn, Wessells, K, Arnold, Charles, Adu-Afarwuah, Seth, Arnold, Benjamin, Ashorn, Per, Ashorn, Ulla, Garcés, Ana, Huybregts, Lieven, Krebs, Nancy, Lartey, Anna, Leroy, Jef, Maleta, Kenneth, Matias, Susana, Moore, Sophie, Mridha, Malay, Okronipa, Harriet, and Stewart, Christine
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antenatal interventions ,balanced energy protein supplementation ,fetal growth restriction ,infant stunting ,infant wasting ,low birth weight ,maternal nutrition ,preterm birth ,Female ,Humans ,Infant ,Newborn ,Pregnancy ,Birth Weight ,Developing Countries ,Dietary Supplements ,Infant ,Low Birth Weight ,Lipids ,Micronutrients ,Pregnancy Outcome ,Prenatal Care ,Prenatal Nutritional Physiological Phenomena ,Randomized Controlled Trials as Topic - Abstract
BACKGROUND: Undernutrition during pregnancy increases the risk of giving birth to a small vulnerable newborn. Small-quantity lipid-based nutrient supplements (SQ-LNSs) contain both macro- and micronutrients and can help prevent multiple nutritional deficiencies. OBJECTIVES: We examined the effects of SQ-LNSs provided during pregnancy compared with 1) iron and folic acid or standard of care (IFA/SOC) or 2) multiple micronutrient supplements (MMSs) and identified characteristics that modified the estimates of effects of SQ-LNSs on birth outcomes. METHODS: We conducted a 2-stage meta-analysis of individual participant data from 4 randomized controlled trials of SQ-LNSs provided during pregnancy (n = 5273). We generated study-specific and subgroup estimates of SQ-LNS compared with IFA/SOC or MMS and pooled the estimates. In sensitivity analyses, we examined whether the results differed depending on methods for gestational age dating, birth anthropometry, or study design. RESULTS: SQ-LNSs (compared with IFA/SOC) increased birth weight [mean difference: +49 g; 95% confidence interval (CI): 26, 71 g] and all birth anthropometric z-scores (+0.10-0.13 standard deviation); they reduced risk of low birth weight by 11%, newborn stunting by 17%, newborn wasting by 11%, and small head size by 15%. Only 2 trials compared SQ-LNSs and MMSs; P values for birth outcomes were >0.10 except for head circumference (e.g., z-score for gestational age: +0.11; 95% CI: -0.01, 0.23). Effect estimates for SQ-LNSs compared with IFA/SOC were greater among female infants and, for certain outcomes, among mothers with body mass index
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- 2024
47. XUV yield optimization of two-color high-order harmonic generation in gases
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Raab, Ann-Kathrin, Redon, Melvin, Abbing, Sylvianne Roscam, Fang, Yuman, Guo, Chen, Smorenburg, Peter, Mauritsson, Johan, Viotti, Anne-Lise, L'Huillier, Anne, and Arnold, Cord L.
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Physics - Atomic Physics - Abstract
We perform an experimental two-color high-order harmonic generation study in argon with the fundamental of an ytterbium ultrashort pulse laser and its second harmonic. The intensity of the second harmonic and its phase relative to the fundamental are varied, in a large range compared to earlier works, while keeping the total intensity constant. We extract the optimum values for the relative phase and ratio of the two colors which lead to a maximum yield enhancement for each harmonic order in the extreme ultraviolet spectrum. Within the semi-classical three-step model, the yield maximum can be associated with a flat electron return time vs. return energy distribution. An analysis of different distributions allows to predict the required relative two-color phase and ratio for a given harmonic order, total laser intensity, fundamental wavelength, and ionization potential.
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- 2024
48. Project MPG: towards a generalized performance benchmark for LLM capabilities
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Spangher, Lucas, Li, Tianle, Arnold, William F., Masiewicki, Nick, Dotiwalla, Xerxes, Parusmathi, Rama, Grabowski, Peter, Ie, Eugene, and Gruhl, Dan
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Computer Science - Software Engineering ,Computer Science - Artificial Intelligence - Abstract
There exists an extremely wide array of LLM benchmarking tasks, whereas oftentimes a single number is the most actionable for decision-making, especially by non-experts. No such aggregation schema exists that is not Elo-based, which could be costly or time-consuming. Here we propose a method to aggregate performance across a general space of benchmarks, nicknamed Project "MPG," dubbed Model Performance and Goodness, additionally referencing a metric widely understood to be an important yet inaccurate and crude measure of car performance. Here, we create two numbers: a "Goodness" number (answer accuracy) and a "Fastness" number (cost or QPS). We compare models against each other and present a ranking according to our general metric as well as subdomains. We find significant agreement between the raw Pearson correlation of our scores and those of Chatbot Arena, even improving on the correlation of the MMLU leaderboard to Chatbot Arena.
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- 2024
49. No Argument Left Behind: Overlapping Chunks for Faster Processing of Arbitrarily Long Legal Texts
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Fama, Israel, Bueno, Bárbara, Alcoforado, Alexandre, Ferraz, Thomas Palmeira, Moya, Arnold, and Costa, Anna Helena Reali
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computer Science - Computers and Society ,Computer Science - Machine Learning - Abstract
In a context where the Brazilian judiciary system, the largest in the world, faces a crisis due to the slow processing of millions of cases, it becomes imperative to develop efficient methods for analyzing legal texts. We introduce uBERT, a hybrid model that combines Transformer and Recurrent Neural Network architectures to effectively handle long legal texts. Our approach processes the full text regardless of its length while maintaining reasonable computational overhead. Our experiments demonstrate that uBERT achieves superior performance compared to BERT+LSTM when overlapping input is used and is significantly faster than ULMFiT for processing long legal documents., Comment: Presented at 15th Symposium in Information and Human Language Technology (STIL) @ BRACIS'24
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- 2024
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50. Evaluation Of P300 Speller Performance Using Large Language Models Along With Cross-Subject Training
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Parthasarathy, Nithin, Soetedjo, James, Panchavati, Saarang, Parthasarathy, Nitya, Arnold, Corey, Pouratian, Nader, and Speier, William
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Computer Science - Human-Computer Interaction ,Computer Science - Computation and Language - Abstract
Amyotrophic lateral sclerosis (ALS), a progressive neuromuscular degenerative disease, severely restricts patient communication capacity within a few years of onset, resulting in a significant deterioration of quality of life. The P300 speller brain computer interface (BCI) offers an alternative communication medium by leveraging a subject's EEG response to characters traditionally highlighted on a character grid on a graphical user interface (GUI). A recurring theme in P300-based research is enhancing performance to enable faster subject interaction. This study builds on that theme by addressing key limitations, particularly in the training of multi-subject classifiers, and by integrating advanced language models to optimize stimuli presentation and word prediction, thereby improving communication efficiency. Furthermore, various advanced large language models such as Generative Pre-Trained Transformer (GPT2), BERT, and BART, alongside Dijkstra's algorithm, are utilized to optimize stimuli and provide word completion choices based on the spelling history. In addition, a multi-layered smoothing approach is applied to allow for out-of-vocabulary (OOV) words. By conducting extensive simulations based on randomly sampled EEG data from subjects, we show substantial speed improvements in typing passages that include rare and out-of-vocabulary (OOV) words, with the extent of improvement varying depending on the language model utilized. The gains through such character-level interface optimizations are approximately 10%, and GPT2 for multi-word prediction provides gains of around 40%. In particular, some large language models achieve performance levels within 10% of the theoretical performance limits established in this study. In addition, both within and across subjects, training techniques are explored, and speed improvements are shown to hold in both cases., Comment: 21 pages, 11 figures, 1 table. arXiv admin note: substantial text overlap with arXiv:2405.13329
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- 2024
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