1. Is hepatic GABA transaminase a promising target for obesity and epilepsy treatments?
- Author
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Kumrungsee T
- Subjects
- Humans, Animals, gamma-Aminobutyric Acid metabolism, 4-Aminobutyrate Transaminase metabolism, 4-Aminobutyrate Transaminase antagonists & inhibitors, Obesity metabolism, Obesity drug therapy, Epilepsy metabolism, Epilepsy drug therapy, Liver metabolism
- Abstract
γ-Aminobutyric acid (GABA) transaminase (GABA-T) is a GABA-degrading enzyme that plays an essential role in regulating GABA levels and maintaining supplies of GABA. Although GABA in the mammalian brain was discovered 70 years ago, research on GABA and GABA-T has predominantly focused on the brain. Notwithstanding the high activity and expression of GABA-T in the liver, the exact functions of GABA-T in the liver remain unknown. This article reviews the up-to-date information on GABA-T in the liver. It presents recent findings on the role of liver GABA-T in food intake suppression and appetite regulation. Finally, the potential functions of liver GABA-T in other neurological diseases, natural GABA-T inhibitors, and future perspectives in this research area are discussed., (© The Author(s) 2024. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.)
- Published
- 2024
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