1. Galactomannan and 1, 3-β-D-Glucan Assay in Bronchoalveolar Lavage Fluid for the Diagnosis of Invasive Pulmonary Aspergillosis in Malignant and Non-malignant Patients
- Author
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Rana El-Gendi, Doaa Ghaith, Soheir Fathy Helal, Hadir A. El-Mahallawy, and Iman K. Behiry
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Non malignant ,General Medicine ,Invasive pulmonary aspergillosis ,Gastroenterology ,respiratory tract diseases ,03 medical and health sciences ,Galactomannan ,chemistry.chemical_compound ,0302 clinical medicine ,Bronchoalveolar lavage ,030228 respiratory system ,chemistry ,Internal medicine ,Positive predicative value ,medicine ,030211 gastroenterology & hepatology ,In patient ,business ,1 3 β d glucan - Abstract
BACKGROUND: Serum 1, 3-β-D-glucan (BDG) assay was recommended for diagnosing fungal infections. AIM: We aimed to assess 1, 3-β-D-glucan in bronchoalveolar lavage (BAL) fluid in invasive pulmonary aspergillosis (IPA). METHODS: Out of 104 patients clinically suspected fungal, 45 were probable, 18 possible, and 41 unlikely according to EORTC/MSG 2008 criteria. Measuring BAL BDG and galactomannan were done. RESULTS: The sensitivity, specificity, and positive and negative predictive values (PPV and NPV) for BDG were 44%, 71%, 62%, and 54%; for galactomannan 84%, 83%, 84%, and 83%; and 93%, 66%, 75%, and 90%, respectively, when combining both tests. A significant different performance of GM; p = 0.0008 was detected in patients with malignant disorders when compared to non-malignant; but not for BDG; p = 0.121. CONCLUSION: We can conclude that BAL-BDG is helpful if positive in a clinically suspected IFI case, but if negative cannot rule out fungal infection. Thus, combining results of BAL-GM and BAL-BDG are recommended.
- Published
- 2021