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Diagnostic Performance of Bronchoalveolar Lavage (1,3)-β-d-Glucan Assay for Pneumocystis jirovecii Pneumonia
- Source :
- Journal of Fungi, Vol 6, Iss 200, p 200 (2020), Journal of Fungi
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- We evaluated the performance of the (1,3)-β-d-glucan (BDG) assay on bronchoalveolar lavage fluid (BALF) as a possible aid to the diagnosis of Pneumocystis jirovecii pneumonia. BALF samples from 18 patients with well-characterized proven, probable, and possible Pneumocystis pneumonia and 18 well-matched controls were tested. We found that the best test performance was observed with a cut-off value of 128 pg/mL; receiver operating characteristic/area under the curve (ROC/AUC) was 0.70 (95% CI 0.52–0.87). Sensitivity and specificity were 78% and 56%, respectively; positive predictive value was 64%, and negative predictive value was 71%. The low specificity that we noted limits the utility of BALF BDG as a diagnostic tool for Pneumocystis pneumonia.
- Subjects :
- Microbiology (medical)
medicine.medical_specialty
Plant Science
Pneumocystis pneumonia
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
030212 general & internal medicine
lcsh:QH301-705.5
Ecology, Evolution, Behavior and Systematics
0303 health sciences
bronchoalveolar lavage fluid
medicine.diagnostic_test
Receiver operating characteristic
030306 microbiology
business.industry
Brief Report
Pneumocystis jirovecii Pneumonia
Area under the curve
medicine.disease
Predictive value
β-d-glucan
respiratory tract diseases
Bronchoalveolar lavage
lcsh:Biology (General)
Test performance
business
1 3 β d glucan
Subjects
Details
- Language :
- English
- Volume :
- 6
- Issue :
- 200
- Database :
- OpenAIRE
- Journal :
- Journal of Fungi
- Accession number :
- edsair.doi.dedup.....ad8e106c7c4fb00f14e2f808a3b303e7