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Objective: To observe the effect of Tongyuan acupuncture method on serum neurotrophic factors and hypothalamic-pituitary-adrenal axis function in patients with post stroke depression (PSD) of liver qi stagnation type. Methods: According to the random number table method, 102 PSD patients admitted to Foshan Hospital of Traditional Chinese Medicine from September 2021 to November 2022 were divided into a control group (n=51, receiving routine treatment) and an observation group (n=receiving Tongyuan acupuncture on the basis of the control group). The efficacy, depression and changes of serum neurotrophic factors and hypothalamic-pituitary-adrenal axis function indexes were compared between two groups. Results: Compared with control group, the total clinical effective rate in observation group was higher(P<0.05). Compared with control group 4 weeks after treatment and 8 weeks after treatment, the Hamilton Depression Scale 24 item version (HAMD-24) score in observation group was lower (P<0.05). Compared with control group 8 weeks after treatment, the serum nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1) in observation group were higher, and the plasma adrenocorticotropic hormone (ACTH), cortisol (Cor) and corticotropin releasing hormone (CRH) were lower(P<0.05). Conclusion: PSD patients of liver qi stagnation type are treat with Tongyuan acupuncture method, the depressive symptoms can be significantly alleviate, the serum neurotrophic factors can be regulate, and the function of hypothalamus-pituitary-adrenal axis can be improve, which has high application value. [ABSTRACT FROM AUTHOR]

During the process of infecting plants,phytopathogenic fungi secrete cell wall degrading enzymes to destroy plant cell walls in order to successfully invade the host. Studies have shown that cellulase,pectinase,xylanase,chitinase,and esterase in the cell wall degrading enzymes secreted by pathogenic bacteria are involved in the process of plant cell wall degradation and pathogenic bacteria. However,there is relatively little research on the function of the lytic polysaccharide monooxygenase in the cell wall degrading enzymes in the process of pathogen invasion of plants. Based on the recent research progress of auxiliary active enzymes and cleavage polysaccharide monooxygenases belonging to the auxiliary active enzymes,this article summarizes the distribution,types,functions of auxiliary active enzymes and the role of cleavage polysaccharide monooxygenases in plant diseases. The research aims to provide reference and basis for the function research and disease prevention and control of auxiliary active enzymes in plant diseases. [ABSTRACT FROM AUTHOR]

Objective: To explore the clinical characteristics, delayed diagnosis factors and complication risk factors of children with tracheobronchial foreign body. Methods: A total of 167 children with suspected tracheobronchial foreign bodies, admitted to our hospital from May 2014 to July 2022, were used as the study subjects. Among the 167 patients, 112 were male and 55 were female, with a mean age (25.10 ± 21.51) months. According to the results of bronchoscopy, the children were divided into foreign bodies (n=140) and non-foreign bodies (n=27). The child was divided into delayed diagnosis group (n=100) and early diagnosis group (n=40) according to whether the diagnosis time of the child was admitted within 24h. All children were divided into complications (n=122) and complications (n=18). Results: There were no significant differences between the foreign body group and the non-foreign body group in terms of gender, age, and time to see a doctor after onset (P>0.05). There were significant differences in the retention site, CRP, PCT, imaging at the first diagnosis, residence of the children and the history of foreign body inhalation(P>0.05). The multivariate logistics regression, with whether delayed diagnosis was the dependent variable, showed that age, imaging at first diagnosis, residence of the child, and history of foreign body inhalation were independent risk factors (P>0.05). The results of multifactorial logistic regression with the occurrence of complications as the dependent variable showed that age, imaging at the first visit, the child's place of residence, delayed diagnosis and history of foreign body aspiration were independent risk factors (P>0.05). Conclusion: Children with tracheobronchial foreign bodies have obvious age characteristics, delayed diagnosis and complications are affected by complex factors such as age, foreign body inhalation history and imaging examination. [ABSTRACT FROM AUTHOR]

Objective To study the efficacy of fibrinogen (FIB) concentrate combined with carboprost tromethamine in the early treatment of postpartum hemorrhage (PPH). Methods Patients with PHH admit-ted to the hospital from January 2018 to May 2021 were selected as study subjects and divided into the experi-mental group (32 cases) and the control group (32 cases) by randomized number tables. The experimental group was treated with (0. 2-0. 3g) / 10 kg FIB concentrate combined with 250 jig carboprost tromethamine, and the control group was treated with 250 pg carboprost tromethamine. The clinical efficacy and blood loss, coagulation indexes [activated partial thrombin time (APTT), plasma thrombin time (TT),prothrombin time (PT),FIB,and D-dimer (D-D)] before and after medication of the two groups were compared. Results The total effective rate of experimental group was 90. 62% (29/32),which was significantly higher than that of the control group 68.75% (22/32),and the difference was statistically significant (P<0. 05). There was no statistical significance in the blood loss between the two groups at 15 min postpartum (P>0. 05), and the blood loss in the experimental group was significantly less than that in the control group at two hours after drug treatment and 24 hours after postpartum, with statistical significance (P<0.05). There was no statistical significance in APTT,TT,PT,FIB and D-D values between the two groups before delivery ( P >0. 05). APTT, TT,PT and D-D values of the experimental group were significantly lower than those of the control group after delivery, while FIB value was significantly less than that in the control group at two hours after drug treatment and 24 hours after postpartum, with statistical significance (P<0.05). There was no statistical significance in APTT, TT,PT, FIB and D-D values between the two groups before delivery (P>0.05). APTT, TT,PT and D-D values of the experimental group were significantly lower than those of the control group after delivery, while FIB value was significantly higher than that of the control group, with statistical significance (P<0.05). Conclusion The combination of FIB concentrate and carboprost tromethamine in the treatment of PPH has better effect, less blood loss and better coagulation function, which is worthy of further clinical research and promotion. [ABSTRACT FROM AUTHOR]

香豆素在自然界中广泛存在于各类植物中, 也存在少数的真菌及细菌中, 是植物次级代谢产 物。香豆素类化合物广泛的药理活性与其结构密不可分。该文对香豆素类化合物来源、结构与分类及抗炎活 性进行了综述。 [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of Liu-Shen-Wan on transplanted tumors in mice with colon cancer based on the polarization of M2 macrophages in the tumor microenvironment. Methods We established a subcutaneous transplantation tumor model of mice with CT26 colon cancer. Mice were randomly divided into vehicle, oxaliplatin, and oxaliplatin combined with Liu-Shen-Wan groups. Treatment was administered for three weeks, and tumor volume was measured. All mice were weighed during the administration. After the end of the treatment, the mice were dissected and tumors were photographed and weighed. Spleen index was calculated. The expression levels of IFN-γ and IL-12P40 in serum and related blood biochemical indices were measured. The expression levels of M2 macrophage polarization indices, namely, IL-10 and TGF-β, in serum and tumor tissues were detected. The infiltration degree of M2 macrophages in each group was observed by immunohistochemical experiments. Results The tumor volume and mouse weight in the oxaliplatin combined with Liu-Shen-Wan group significantly decreased compared with those in the vehicle group. The spleen index increased, and the expression levels of IFN-γ and IL12P40 in serum also significantly increased. The mice had no obvious side effects after the drug treatment. In addition, the expression levels of IL-10 and TGF-β in the serum and tissues of mice in the oxaliplatin combined with Liu-Shen-Wan group significantly decreased. The expression levels of CD68 and CD206 in tumor tissues also decreased. Conclusion The anti-tumor effect of Liu-Shen-Wan on the transplanted tumors of mice with colon cancer is related to the inhibition of M2 macrophage polarization in the tumor microenvironment. [ABSTRACT FROM AUTHOR]

With lithium acetate and butyl titanate as lithium and titanium sources, and cetyltrimethylammonium bromide (CTAB) as the soft template, the sol-gel method is used to obtain CTAB-added lithium titanium by roasting. The compound (Li4Ti5O12) was pickled with hydrochloric acid to prepare a lithium titanium ion sieve (H4Ti5O12, HTO). The effects of crystal phase, morphology and time on the adsorption capacity of lithium titanium ion sieve were investigated by thermogravimetric analysis (TG-DTG), X-ray diffraction (XRD), scanning electron microscopy (SEM), contact angle and performance tests. Compared with the addition amount of CTAB, 0.1 g CTAB ionic sieve precursor has fewer impurities and pure crystal phase. The quasi-second-order kinetic correlation coefficient R²(0.997 24) of HTO is greater than that of first-order kinetic correlation coefficient R²(0.984 35), indicating that the adsorption process is consistent with chemisorption. The adsorption capacity of HTO in Li+ solution for 24 h reaches 24.44 mg/g, and after 8 times of adsorption and desorption, the adsorption capacity remains at 23.68 mg/g, only reduces by 3.1%. Therefore, HTO has good cyclic adsorption performance and stability, and has a broad market prospect. [ABSTRACT FROM AUTHOR]

To study the performance of system combining common development and energy storage of deep geothermal energy under sustainable development conditions, seven evaluation criteria were defined. Thermal breakthrough time, water level and vertical displacement were used to assess the sustainable development of deep geothermal energy, and total recoverable energy, stored energy, energy gain coefficient and energy recovery efficiency were used to assess the operating performance of proposed system. Based on the well system which consists of two production wells and one injection well in Juancheng geothermal field, the coupled thermo-hydro-mechanical processes subject to seasonal exploitation and storage were demonstrated and the rationality and applicability of proposed evaluation criteria were validated, using the integrated geothermal reservoir model. The results showed that recoverable heat energy could increase about 360% by adding artificial thermal storage into common geothermal reservoir development, and the proposed system could meet the sustainable development demands of thermal breakthrough time, water level and vertical displacement. It is strongly recommended to add energy storage into the future geothermal reservoir development system, which promotes the development and utilization of urban deep geothermal energy on a larger scale and with higher quality. [ABSTRACT FROM AUTHOR]

OBJECTIVE: The perioperative optimization measures of accelerated rehabilitation surgery run through the whole hospitalization period of patients with open spinal surgery. The clinical efficacy and safety of tranexamic acid in open spinal surgery were evaluated using meta-analysis. METHODS: Databases of PubMed, Embase, Ovid, Cochrane Library, CNKI, CBM, Wanfang, and VIP were searched. According to the inclusion and exclusion criteria, ten prospective randomized controlled trials were obtained. Endnote software was utilized to manage the literature. The extracted data were analyzed using Revman 5.3 software for meta-analysis, mainly analyzing the intraoperative blood loss, postoperative blood loss, total perioperative blood loss, postoperative hemoglobin, operation time, length of hospital stay, blood transfusion rate, and thrombotic complications by using tranexamic acid in open spinal surgery. RESULTS: (1) A total of 10 high-quality prospective randomized controlled studies were included in 802 patients. (2) Meta-analysis results showed that tranexamic acid significantly reduced intraoperative blood loss (MD=-210.38, 95%CI: -267.31 to -153.45, P < 0.000 01), postoperative drainage (MD=-113.40, 95%CI: -126.97 to -99.83, P < 0.000 01), total perioperative blood loss (MD=-266.85, 95%CI: -351.18 to -182.52, P < 0.000 01), and postoperative hemoglobin loss (SMD=0.20, 95%CI: 0.02-0.38, P=0.03) compared with the control group, with significant difference. Moreover, the length of hospital stay (MD=-1.09, 95%CI: -1.86 to -0.32, P=0.006) significantly reduced, and blood transfusion rate (RR=0.61, 95%CI: 0.48 to 0.79, P=0.000 1) significantly reduced. Operation time (MD=-7.75, 95%CI: -16.65 to 1.15, P=0.09) did not shorten. (3) There was no significant difference in the incidence of thrombotic complications between the tranexamic acid group and the control group (RR=0.92, 95%CI: 0.47 to 1.82, P=0.81). CONCLUSION: Tranexamic acid can significantly reduce the perioperative blood loss of open spine surgery, shorten hospital stay, lower blood transfusion rate, and is safe and reliable. The use of tranexamic acid in open spinal surgery can promote enhanced recovery of patients after surgery; the initial dose of tranexamic acid is 10-15 mg/kg, maintenance dose 1.0-2.0 mg/kg per hour. It may be the best solution for intravenous tranexamic acid in open spine surgery. [ABSTRACT FROM AUTHOR]

Objective: To investigate the characteristics of a asymmetry in adults with attention-deficit/hy peractivity disorder ( ADHD), and the relationships with ecological executive function (EF). Methods: Forty-nine a dults diagnosed with ADHD and 45 normal subjects were recruited. The self-ratings of Behavior Rating Inventory of Executive Function, Adult Version (BRlEF-A) were used to measure the ecological EF. The subjects were recorded with EEG signals during an eye-closed resting-state condition. The absolute power in a band was analyzed, and the a absolute power of different regions and the correlations with ecological executive function were analyzed. Results: The a absolute power asymmetries of frontal and forehead were lower in patients with ADHD than in normal controls ( Ps < 0. 05). The ADHD group showed significantly higher indices ofbehavioral regulation and metacogniton in BRIEF-A than control group ( Ps < 0. 001) . In the control group, the a absolute power asymmetries of FP2-FP1 (r = 0. 43, P < 0. 05) and F4-F3 ( r = 0. 43, P < 0. 05) were positively correlated with the moni tor scores, but there was no correlation between the a absolute power asymmetry and EF in adults with ADHD. Conclusion: This study demonstrated the ecological EF deficiencies exist in adults with ADHD, and abnor mal frontal a absolute power asymmetry may be involved in the neuropathological mechanism of impaired self-mo nitor ability of adult ADHD patients. [ABSTRACT FROM AUTHOR]

Objective: To explore the characteristics of resting state electroencephalogram (EEG) in adults with attention-deficit/hyperactivity disorder ( ADHD ) and their correlations with executive function deficits. Methods: Totally 33 adults with ADHD and 30 normal controls were selected to evaluate their eco-executive function by the Behavior Rating Inventory of Executive Function (Adult Version, BRIFF-A) . The absolute power of EEG at different frequency bands and their correlations with executive function deficits were analyzed. Results: The scores of all factors of ecological executive function and the absolute power of 6 wave in whole brain and the absolute power of ~ in central region were higher in ADHD group than in the control group ( P < 0. 01). The working memory scores in patients with ADHD were positively correlated with the absolute power of bilateral frontal 6 wave ( r = 0. 43, 0. 49, Ps < 0. 05), the emotional control scores were positively correlated with the absolute power of ~ wave in bilateral central regions ( r = 0. 43, 0. 49, Ps < 0. 05). Conclusion: It indicates that there are deficits of the ecological executive function in adults with ADHD. The abnormal power of 6 wave in frontal lobe and ~ wave in central parietal lobe of adult ADHD may be involved in the neuropathological mechanism of working memory deficit and poor emotion control respectively. [ABSTRACT FROM AUTHOR]

The Sri Lankan Port City project provides land for urban construction through land reclamation, a large number of dredgers, traffic vessels, and cargo ships are employed during the construction process. Therefore, it is necessary to simulate the wave field during the construction process to evaluate the influence of waves on engineering ships. Based on GFS sea surface wind field data and GEBCO water depth data, the wave numerical models Wave Watch III and SWAN were nested in multiple layers to establish a numerical simulation system suitable for wave field in the Port City area of Sri Lanka. The system was verified by comparing with the measured data. Based on this system, numerical analysis was conducted on the wave field in the Port City construction area at different construction stages. The trend of wave height, period and direction in the whole construction process of typical construction site was obtained. This paper provides an effective method for the numerical simulation of wave fields in nearshore waters, and provides an important reference basis for the reasonable arrangement of engineering ship operation window and the improvement of construction efficiency. [ABSTRACT FROM AUTHOR]

The Japanese Society of Gastroenterology (JSGE) first published evidence-based clinical practice guidelines for cholelithiasis in 2010, followed by a revision in 2016. In April 2023, JSGE published the 2021 edition of evidence-based clinical practice guidelines for cholelithiasis based on the clinical issues associated with cholelithiasis in the databases such as Medline, Cochrane, and Igaku Chuo Zasshi and the latest evidence in literature published in the past five years. The revised edition reviews related clinical questions in the previous edition from the aspects of the epidemiology, pathogenesis, diagnosis, treatment, prognosis, and complications of cholelithiasis and reclassifies them into three categories, with 52 questions in total, among which there are 29 background questions dealing with basic background knowledge, 19 clinical questions, and 4 future research questions requiring further accumulation of evidence, thereby providing guidance for decision making in the clinical management of patients with cholelithiasis. [ABSTRACT FROM AUTHOR]

The effect of intersection angle on the primary and secondary atomization of vacuum induction melting gas atomization (VIGA) was studied by the combination of experiments and computational fluid dynamics CFD simulations. The VOF (volume of fluid) multiphase flow model based on the Euler-Lagrange method was used to simulate the primary atomization process and the discrete phase model (DPM) was used to simulate the breakup process and predict the particle size distribution (PSD) of Taylor analogy breakup (TAB) in secondary atomization. The results show that the simulated area of recirculation zone decreases with the increase of intersection angle. The fragmentation morphology of metal melt is presented as "fountain→umbrella" and the primary droplets size is 0.3~0.9mm. The Weber number (We) of liquid droplets is 10~90. With increasing intersection angle， the average particle size of the powders decreases gradually. Moreover， these simulation results prove reasonable， which the simulated particle size of the powders is in agreement with the experimental one when the intersection angle is 36°. [ABSTRACT FROM AUTHOR]

In the design process of the submerged floating tunnel, it is necessary to carry out the hydrodynamic engineering test to determine the relevant hydrodynamic parameters, and verify the feasibility of the scheme. There is no engineering case of SFT and no monitored date, the physical model test approach is critical in making breakthrough of this engineering technique. In this paper, the physical model test method of SFT was discussed with reference to the marine and ocean engineering test method. The basic principles of model tests including the dimensionless similarity criterion and the technology of fluid velocity measurement were discussed. Then hydrodynamic test contents of SFT were elaborated, covering the towing test for tunnel body, wave effect on tunnel body, plane motion mechanism (PMM) test, the circulating water channel test, the vortex-induced motion (VIM) test, the ocean basin test and the hydroelastic model test; test principles. Testing procedures and key influential factors of the result were given in detail correspondingly. [ABSTRACT FROM AUTHOR]

In this paper, the computational fluid dynamics software FLUENT was used to establish the cross-sectional flow model of the submerged floating tunnel with different characteristics in the uniform flow field, and to study the characteristics of forces and flow field of different sections. The results show that: 1) the drag coefficient and lift coefficient of ellipse section are relatively small, while those of square section are relatively large; The vortex shedding frequency of ellipse section is larger than that of square section. 2) the separation angle of square section is the smallest, while the separation angle of long-tip square section is the largest. 3) the length of back flow area and wake area of circle section is the minimum, and the length of backflow area and wake area of double square section is the maximum; the wake area of the long-tip square section has the smallest width while the square section has the largest width. [ABSTRACT FROM AUTHOR]

In this paper, 25 characterized cross-section of submerged floating tunnel were introduced, and the drag coefficients, lift coefficients, added-mass coefficients, water damping, vertical force, horizontal force and bending moment of those sections were derived; the former four were by CFD method, the latter three by potential theory. Further study subjects were proposed such as the problem of "resistance" and "yield", cross-section comparison and critical parameter analysis. [ABSTRACT FROM AUTHOR]

Using the computational fluid dynamics software Fluent and its user-defined function (UDF) to establish the vortex induced motion model of different typical cross-sections of submerged floating tunnels (SFT) in uniform flow field, and to study the motion characteristics of different cross-sections. It is found that: 1) the displacement amplitude analysis results of different cross-sections show that the displacement of the double-square section is smaller than the double-round and single-round section; 2) two sections are selected to analyze the displacement amplitude, motion trajectory and vortex shedding mode under various reduction rates. The results indicate that the displacement amplitude will increase significantly in the lock-in range; 3) the vortex-excited motion models with different system stiffness were established and the force changes of the tube were analyzed. The results show that when the resonance occurs, the force of the tube will increase obviously; 4) compared with circular shape cross-section, when the constraint of square cross-section is weak, the force is increased evidently and the frequency of vortex is decreased obviously. [ABSTRACT FROM AUTHOR]

BACKGROUND: Clinical conservative treatment can easily lead to the recurrence of lumbar disc herniation. Backward walking is a popular rehabilitation exercise method for the treatment of lumbar disc herniation. After clinical guidance treatment, patients walk backwards and follow up statistics, confirming that walking backwards is an effective rehabilitation exercise therapy. OBJECTIVE: Based on biomechanics, the significance of backward walking for lumbar rehabilitation was explored by finite element analysis. METHODS: The three-dimensional model of lumbar spine was established based on CT images, and then the mechanical conditions of lumbar spine were simulated. The finite element method was used to examine the role of backward walking in the treatment of lumbar disc herniation from the mechanical point of view. RESULTS AND CONCLUSION: (1) The displacement of L1-L2 intervertebral disc was only 1/2 of that of the gait, and the stress of the intervertebral disc was greatly reduced when walking backwards. (2) The stress of L1-L2 intervertebral disc during gait progression was 2.35 times as much as that during walking backwards. (3) Therefore, the changes of stress and displacement of lumbar spine and intervertebral disc are smaller than that of normal gait, which reduces the pressure on nucleus pulposus and helps the recovery of patients with lumbar disc herniation. [ABSTRACT FROM AUTHOR]

In order to explore the pollination biology characteristics of Pleione formosana Hayata, their flowering phenology, pollen vigor, stigma receptivity, breeding systems, and insect pollination behaviors were observed for 2 consecutive years in the Daiyunshan National Nature Reserve in Fujian. It was found that Bombus trifasciatus and Bombioxylocopa chinensis are the pollinators of P. formosana. The thorax heights of Bombus trifasciatus and Bombioxylocopa chinensis were (1.4±0.2) cm and (1.5±0.2) cm, respectively, both of which were higher than the height of the pollination channel entrance by (0.8±0.2) cm. The pollinating insect enters the flower through the mid-lobe of the outer bending lip. When it finds no nectar as reward, it exits the flower; the anther cap will then open causing the viscidium of the pollinium to adhere to the back of the pollinator. When the pollinator enters the same flower or different flowers, the pollination may be completed. It is speculated that P. formosana may attract insects through its golden yellow stripes (fake nectar-guide) on its lips for pollination, which is food-deceptive. Breeding experiments showed that P. formosana is highly self-compatible and that there is no apomixis or self-pollination. The pollination success of this species depends on its pollinators. Therefore, the population density of pollinators and their frequency of visiting flowers may be important factors affecting the fruit set of P. formosana, and ultimately affect the maintenance and expansion of its population. [ABSTRACT FROM AUTHOR]

Objective To investigate the associations between genetic variations of DNA polymerase kappa (POLK) and treatment response to platinum-based chemotherapy of small cell lung cancer (SCLC), and to analyze the influencing factors on survival. Methods Five haplotype-tagging single nucleotide polymorphisms (htSNPs) of POLK were genotyped by Sequenom MassARRAY methods in 1 030 SCLC patients who received platinum-based chemotherapy, and had different response and survival time. The associations between SNPs and treatment response were analyzed by computing the odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regression model. Cox regression was used for survival analysis between SNPs and overall survival by computing the hazard ratios (HRs) and 95% CIs. Results Among 1 030 cases, 558 (54.2%) cases received cis-platinum and etoposide treatment while others treated with carboplatin and etoposide. Seven hundred and eighty eight patients were chemotherapy responders in the study with a response rate of 76.5%. The median follow-up time of these patients was 22.0 months. Patients were followed up to get their survival information. The median survival time of these patients was 22.5 months. Six hundred and seventy three patients (65.3%) had died by the last date of follow-up to get their survival information (Dec 21, 2017). Five htSNPs of POLK were not associated with the chemotherapy response of SCLC patients who received platinum-based chemotherapy (all P>0.05). Multivariate Cox proportional hazards regression model analysis showed that, rs73120833 of POLK was significantly associated with the overall survival (OS) of SCLC patients, compared with POLK rs73120833 T allele, C allele can prolong OS (adjusted HR=0.87, 95% CI=0.77-0.97, P=0.021). The remaining 4 SNPS, including rs10077427, rs3756558, rs4549504 and rs5744545, were not significantly associated with overall survival. Age≤56, KPS> 80, limited-stage, chemotherapy response and radiation therapy can remarkably prolong OS (all P<0.05). Conclusion These results suggest that POLK genetic polymorphism rs73120833 plays an important role on the prognosis of SCLC patients, which can be potential genetic biomarker for SCLC personalized treatment. [ABSTRACT FROM AUTHOR]

Moisture content of grain is one of the greatest significant factors affecting the quality of food, which still plays an important role as an indicator in food storage, acquisition, processing,transportation, and so on. Recently, as the rapid development of the intelligent combine harvester, intelligent harvest and yield measurement have become possible. It is necessary to monitor the moisture content of grain in real time in automatic harvest. In addition, only when the weight of the harvested grain is converted to the weight of the grain with a fixed moisture content, the yield information can be measured more accurately, and the cause of loss rate can be analyzed more comprehensively. Comparing the domestic machine with that in other countries, the fact is that some latest combine harvesters designed in other nations have installed the real-time grain moisture content monitoring system, while the majority of the domestic combine harvesters have not yet used this technology in practice. By virtue of the huge cost of introducing the measurement systems from other nations, the import of this machine has not been applied in agriculture industry universally. Therefore, in the light of this situation, the research on the on-line monitoring of the grain moisture content for the combine harvester will be of great value in the domestic area to some extent. In order to analyze the influence of edge effect on the capacitive plate, a finite element analysis software COMSOL Multiphysics was adopted to establish the capacitive plate and its working environment model. The influences of the thickness of the capacitive plate, the plate spacing and the relative area on the edge effect have been evaluated. The three-factor and three-levelorthogonal experiment optimization simulation was carried out, using capacitance ratio and sensitivity as the evaluation indicator. According to the simulation results, a copper plate with a plate thickness of 0.15 mm, a plate spacing of 20 mm and a relative area of 3 000 mm2 between the plates was selected. Based on the STM32F103 series microprocessor chip, an on-line monitoring system of grain moisture has been constructed. This system included the power supply module, high frequency excitation signal module, AC (alternating current) small signal amplification circuit, capacitor plate, signal conditioning circuit, mean response power detector, and other designed sensor detection circuits. For the aim of the more accurate consequence of the monitor with respect to the moisture content of cereals, simplifying the circuit structure and reducing the cost, Multisim simulation and experimental verification were carried out on various frequency sources respectively. Then, the high frequency signal with the frequency of 10 MHz was selected as the excitation signal of the monitoring device. Finally, in order to get the changing relationship between the moisture content and the voltage, the output signal of the circuit was converted from a non-sinusoidal wave caused by the capacitor charge and discharge to a DC (Direct Current) voltage by a mean response power detector taking the AD8361 as a core. Moreover, the device could monitor the grain moisture content on-line, and real-time display and store information The indoor static monitoring and on-field monitoring test were conducted withthe on-line monitoring device of grain moisture content. As a result, the maximum relative error of indoor static monitoring test was 1.57% and the maximum relative error of field monitoring test was 2.07%. [ABSTRACT FROM AUTHOR]

The extraction of inulin from Jerusalem artichoke was carried out by hydrothermal method. Through designing single factor experiment, three main factors affecting the extraction temperature, time and phosphoric acid concentration were determined. Using response surface method for optimal analysis of the extraction process of inulin, using the Design-Expert software to design three factors and three levels of experiments, obtained the best extraction conditions of inulin; water bath temperature 87 °C, extraction time 82 min,phosphate concentration 0.7 g/L,under this condition,the extraction rate of inulin reached 22.44%. The results are consistent with the predicted values, which proves that the prediction model is effective and can be used to optimize the extraction process of inulin. This study provides theoretical basis and data support for the further development and utilization of Jerusalem artichoke in plateau area. [ABSTRACT FROM AUTHOR]

Aiming at the problem that combine harvester cannot obtain reliable grain flow information in complex noise background, wavelet transform (WT) is proposed to denoise the output signal of grain flow sensor. The method is as follows: using the LabVIEW data acquisition card to acquire the output signal of the grain flow sensor and analyzing the amplitude-frequency characteristics of signal, in which the energy-dominant frequency band is set as the grain effective signal, and the chaotic and the frequency band with flat amplitude change are set as the noise signal. The spectrum of original signal and noise is used to determine how to choose the wavelet function and decomposition scale. By analyzing the amplitude-frequency characteristics of the original signal, the energy-dominant center frequency in the grain flow is 40 Hz, and the noise is distributed in 2 frequency bands, of which the signal energy attenuation is faster, the bandwidth distribution is narrower and the change trend is consistent with the original signal in 500-600 Hz band, so the bands are the vibration noise of the yield platform. Above 800 Hz the signal changes slowly in energy attenuation, the bandwidth distribution is wide and the changes are random, so the bands are the high-frequency noise of the yield platform. In the research, the yield measuring system is designed to obtain the yield information. The Mallat algorithm is applied to decompose and remove the noise components of grain flow signal, the DB4 wavelet is chosen as the wavelet function and the decomposition scale is 6. The effective data of grain flow are reconstructed by wavelet and calibrated by the analog to digital converter channel of microcomputer. The maximum relative error of the grain mass is 1.68% under different grain flow after calibration. The position data are obtained by the Beidou Navigation Satellite System (BDS) with the pseudo-range differential position technology. The yield measuring system is installed on the combine harvester to simulate the rice operation experiment. The quantitative rice is transported to the grain tank and output at different rates per unit time, and the speed of driving wheel of the grain-conveying auger is gradually increased in the grain flow experiment. After the WT for the output signal of the flow sensor, reconstructing the base frequency of the grain flow information can be removed by the vibration noise. The relative error of the grain flow measurement is 6.18% and the average relative error is 5.37%. The yield data recorded in the production system are imported into the PC (personal computer) to plot the yield map. The map confirms that the BDS differential location data are reliable and the grain flow information in the test area is consistent with the experiment. Through the WT of the information output by grain flow sensor, the spectrum of the signal after the wavelet denoising is compared with the original signal, and the feasibility and the accuracy of the flow signal denoising are validated as well as the grain flow information reconstructing method based on the Mallat algorithm. This research can provide a reference for the original information denoising and the reconstructing of effective information in the complex operating environment of agricultural machinery. [ABSTRACT FROM AUTHOR]

This study aims to explore the genetic polymorphism of rapedseed materials in southern areas of Shaanxi Province, unreveal the genetic background, identify the relationship among all materials, and provide the theoretical basis for rapedseed breeding. Genetic diversity of 56 Brassica napus inbred lines in southern Shaanxi were investigated using variable renaturing temperature-based PCR, in which 34 pairs of SRAP markers and 25 pairs of SSR markers were employed. The results demonstrated that total 273 alleles were verified using SRAP markers, in which 8 alleles were detected by per pair of molecular markers. And genetic polymorphism information content of each SRAP locus was between 0.32 -0.93 , with an average of 0.64. Meanwhile 168 alleles were found using SSR, and 7 alleles were achieved per pair of SSR markers. Genetic polymorphism information content of each SSR locus was between 0.03 -0.92, and the average of which was 0.54. Additionally, the genetic similarity of the 56 varieties ranged from 0.34 to 0.93 with an average value of 0.69 for SRAP and from 0.30 to 0.92 with an average value of 0.57 for SSR. Cluster analysis showed that genetic similarity coefficient of 56 different materials were 0.47 - 0.93 for SRAP and 0.49 - 0.92 for SSR markers, respectively. UPGMA cluster analysis of genetic similarity showed that all the materials were clustered into one group at the genetic similarity of 0.47 for SRAP and 0.49 for SSR. By comparison, SRAP showed higher potential in determining genetic polymorphism than SSR. Very narrow genetic background was observed for the most materials of 56 inbred Brassica napus lines in this study. It is an urgent task for Brassica napus breeders to introduce diversified germplasm resources into Brassica napus breeding program. [ABSTRACT FROM AUTHOR]

The geographical traceability of ivory intercepted at frontier ports is an important prerequisite for identifying the source of illegal ivory,determining the major poaching hotspots,describing the smuggling channels and cracking down on the illegal trade of ivory.In this study,we used the method of mitochondrial DNA haplotype to trace the geographical origin of 126 ivory samples intercepted at frontier ports in China.A total of 22 geographic haplotypes were identified from 126 samples,including two clades and seven subclades.Through the comparative analysis of Loxodonta Localizer database,the geographic origin of 109 samples was determined,and then inferred three sources:Tridom protected ecosystem in the Congo Basin of Central Africa; Kenya,Tanzania and Uganda in East Africa and the Kavango-Zambezi(KAZA)Transfrontier Conservation Area of southern Africa.These three areas are also internationally recognized as the most serious hot spots for ivory poaching.Combining the traceability results with the ivory poaching,trafficking and smuggling networks of transnational criminal organizations will provide effective information and focus for customs anti-smuggling departments to combat the international ivory smuggling chain. [ABSTRACT FROM AUTHOR]

A new static aeroelastic analysis method for the HAWT was proposed based on the modified blade element momentum (BEM) theory. The deformation curves of the blade under different steady wind speeds were analyzed. The prebending design principles and a profile design method were developed. The static aeroelastic analyzing result of the prebending and unprebending blade shows that， the aerodynamic performance is influenced by the cross section shape change， blade axial and torsional deformation. The prebending blade’s actual power has certain decrease because of the blade torsional deformation. This study provides theoretical basis and design method for the blade. [ABSTRACT FROM AUTHOR]

Considering the low structural performance of wind turbine airfoils designed just with aerodynamic performance as an optimization objective， a new multi-objective optimization method is proposed based on improved multi-objective particle swarm optimization， which balances aerodynamic and structural performance of airfoils. The airfoils with thickness of 40% are parametrically described using the wind turbine airfoil integrated theory. The optimization objectives are the maximum lift-drag ratio when designing attack angles and the maximum inertia moment about the chord axis， with such requirements as stalling characteristics， sensitivity to leading edge roughness and design lift at off-design condition considered together. The Pareto-optimal set of airfoils is obtained. The representative airfoils in the set outperform the airfoil (DU00-W2-401) in terms of aerodynamic and structural performance. [ABSTRACT FROM AUTHOR]

Most of the airfoil representations do not have a large enough domain to select the optimal airfoil in that they mainly depend on control points and initial airfoils. Based on the parametric profile representation， which originated from Joukowski conformal transformation， an improved genetic algorithm was designed to obtain airfoils with a high lift-to-drag ratio. ICEM and FLUENT were coupled to generate airfoils， reconstruct mesh， set boundary conditions and calculate aerodynamic performances. The results showed that the new airfoil has a higher lift coefficient and lift-to-drag ratio in on-design and off-design operation conditions and at the main range of attack angles. This multidisciplinary design integrates well parametric representation and CFD simulation， which can also provide a reference for similar aerodynamic optimization designs. [ABSTRACT FROM AUTHOR]

The aim of this study was to investigate the effects of black carbon (BC) addition on soil organic carbon (SOC) mineralization and soil nutrients. BC was produced by pyrolysis of Cunninghamia lanceolata litter in the laboratory at nine temperatures (300- 700℃). Soil was mixed with BC material and incubated for 28 days. The results indicated that the soil CO2 emission rate was higher at the earlier stage of incubation( 0- 3 d), and became slower in the later phase( 3- 28 d). The accumulation amounts of soil CO2-C were increased with temperature increase. Compared to control soil,there was a significant increase in soil organic carbon,available P, available K and soil p H with BC additions treatment,but a small decrease in soil available N. This paper can provide the scientific information for BC application in reducing forest soil carbon emission and increasing soil fertility. [ABSTRACT FROM AUTHOR]

BACKGROUND: After the medial open wedge high tibial osteotomy, the deformity of lower limb force line moving inward and knee varus can be corrected, which will inevitably lead to compensatory changes in the position of adjacent joints to adapt to the new force line. Up to now, there are relatively few studies to systematically and comprehensively measure the compensatory changes of hip joint, patellofemoral joint, ankle joint and other adjacent joints from the perspective of imaging. OBJECTIVE: To analyze the compensatory changes of hip joint, patellofemoral joint, and ankle joint caused by the changes of lower limb force line from the perspective of imaging after medial open wedge high tibial osteotomy. METHODS: The imaging data of 49 patients who underwent medial open wedge high tibial osteotomy in Affiliated Hospital of Qingdao University from June 2016 to December 2019 were retrospectively analyzed. To evaluate the efficacy of lower limb line correction after medial open wedge high tibial osteotomy, hip-knee-ankle angle, lateral distal femoral angle, medial proximal tibial angle, joint line convergence angle, weight bearing line ratio, and tibial posterior slope were measured in all patients with preoperatively and immediately postoperatively and at the end of the follow-up. To evaluate the compensatory changes of hip joint, patellofemoral joint, and ankle joint after medial open wedge high tibial osteotomy, the hip abduction angle, tibial plafond inclination angle, talar inclination angle, Caton-Deschamps index, lateral patellar shift, lateral patellar tilt, medial space of patellofemoral joint, and lateral space of patellofemoral joint were measured in all patients before treatment and after the last follow-up. RESULTS AND CONCLUSION: (1) After medial open wedge high tibial osteotomy, the lower extremity line correction of the patients was satisfactory, and there was statistical significance in the comparison of hip-knee-ankle angle, medial proximal tibial angle, joint line convergence angle, and weight bearing line ratio before and immediately after the operation, and in the last follow-up (P < 0.05). (2) There was no increase in tibial posterior slope after medial open wedge high tibial osteotomy, and there was no significant difference between tibial posterior slope before and after treatment (P > 0.05). (3) The hip adduction was aggravated after treatment, and the difference between preoperative and last follow-up of hip abduction angle was statistically significant (P < 0.05). An ankle varus was corrected after treatment, and the difference between tibial plafond inclination angle and talar inclination angle before surgery and the last follow-up was statistically significant (P < 0.05). (4) The position of patella decreased after treatment, and the difference of Caton-Deschamps index between preoperative and postoperative data was statistically significant (P < 0.05), but there was no anteroposterior and lateral displacement, or patella tilt (P > 0.05). [ABSTRACT FROM AUTHOR]

Objective To optimize the freeze-drying technology of demethoxy curcumin nanostructured lipid carriers. Methods With the appearance! color and redispersibility as the investigation indexes ' the influence of types and concentrations of cryoprotectant on nanostructured lipid carriers freeze-dried powder was investigated and the parameters of freeze-drying technology was optimized. Results The optimized freeze-drying technology was as follows) adding 5% mannitol as a cryoprotectant into nanostructured lipid carriers emulsion! prefreezing at -80 # for 24 h after shaking! heating up to -35 # ' maintaining for 16 h, then heating up to 30 # and maintaining for 8 h. Conclusion The freeze-dried powder obtained by adopting optimized technology is loose and easy to be dispersed, which improves the stability of preparation. [ABSTRACT FROM AUTHOR]

目的：评价来曲唑联合唑来膦酸治疗雌激素受体（ ER）／孕激素受体（ PR）阳性的绝经后乳腺癌骨转移患者的疗效。方法绝经后乳腺癌骨转移患者124例，ER阳性69例，PR阳性55例，ER、PR均阳性43例。采用来曲唑联合唑来膦酸治疗64例（联合组），采用唑来膦酸治疗26例（唑来膦酸组），采用来曲唑治疗34例（来曲唑组）。观察三组骨转移灶治疗效果、骨转移性疼痛镇痛效果、不良反应发生情况。结果唑来膦酸组完全缓解0例、部分缓解2例、稳定7例、进展17例，有效率34．6％；来曲唑组分别为0、3、11、20例和41．2％；联合组分别为2、10、28、24例和62．5％；联合组有效率高于唑来膦酸组和来曲唑组（ P均＜0．05）。唑来膦酸组镇痛显效4例、有效7例、无效15例，镇痛有效率为57．7％；来曲唑组分别为5、10、19例和55．9％；联合组分别为12、37、15例和76．6％；联合组镇痛有效率高于唑来膦酸组和来曲唑组（P均＜0．05）。唑来膦酸组发生发热5例、流感样症状3例、晚期骨关节症状0例、低钙血症3例、肾功能一过性损害1例，来曲唑组分别为0、1、5、4、0例，联合组分别为12、8、8、5、2例，三组不良反应发生情况相比，P均＞0．05。结论来曲唑联合唑来膦酸治疗ER／PR阳性的绝经后乳腺癌骨转移患者可缩小骨转移灶，缓解骨痛，且不良反应较轻，效果优于来曲唑或唑来膦酸单药应用。 [ABSTRACT FROM AUTHOR]

Objective To explore the radiosensitivity of β-elemene on Colo320 cells transplanted tumor in nude mice and its molecular mechanisms. Methods Colo320 cells transplanted tumor model was established by cell suspension inoculation in nude mice. Then the transplanted mice with 0.8-1.0cm3 tumor were randomly divided into 4 groups: control, β-elemene (40mg/kg), radiation (4Gy), and β-elemene (40mg/kg) + radiation (4Gy) groups, with four to five mice in each. Tumor weight and morphology were observed in each group. In addition, the apoptosis of tumor cells was measured by TUNEL and the expression of Fas gene was detected by immunohistochemistry. Results The nude mice transplanted tumor model was successfully established. Compared with that in control and simple radiation groups, tumor weight was significantly decreased in β-elemene combined with irradiation group (P<0.05). At the same time, the apoptosis rate and the expression of Fas gene in tumor cells were significantly increased (P<0.05) in β-elemene combined with irradiation group compared with control and simple radiation groups. Conclusion β-elemene could enhance the radiosensitivity of Colo320 cells transplanted tumor in nude mice probably by inducing Fas-mediated apoptosis of tumor cells. [ABSTRACT FROM AUTHOR]

Objective This study aims to investigate the associations between genetic variations of pyroptosis pathway related key genes and adverse events (AEs) of postoperative chemoradiotherapy (CRT) in patients with rectal cancer. Methods DNA was extracted from the peripheral blood which was collected from 347 patients before CRT. Sequenom MassARRAY was used to detect the genotypes of 43 haplotype-tagging single nucleotide polymorphisms (htSNPs) in eight pyroptosis genes, including absent in melanoma 2 (AIM2), caspase-1 (CASP1), caspase-4(CASP4), caspase-5 (CASP5), caspase-11 (CASP11), gasdermin D (GSDMD), gasdermin E (GSDME) and NLR family pyrin domain containing 3 (NLRP3). The associations between 43 htSNPs and AEs were evaluated by the odd ratios (ORs) and 95% confidence intervals (CIs) by unconditional logistic regression models, adjusted for sex, age, clinical stage, tumor grade, Karnofsky performance status (KPS), surgical procedure, and tumor location. Results Among the 347 patients with rectal cancer underwent concurrent CRT with capecitabine after surgery, a total of 101(29.1%) occurred grade ≥ 2 leukopenia. rs11226565 (OR=0.41, 95% CI: 0.21-0.79, P=0.008), rs579408(OR=1.54, 95% CI: 1.03-2.29, P=0.034) and rs543923 (OR=0.63, 95% CI: 0.41-0.98, P=0.040) were significantly associated with the occurrence of grade ≥ 2 leukopenia. One hundred and fifty-six (45.0%) had grade ≥ 2 diarrhea, two SNPs were significantly associated with the occurrence of grade ≥ diarrhea, including CASP11 rs10880868 (OR=0.55, 95% CI: 0.33-0.91, P=0.020) and GSDME rs2954558 (OR=1.52, 95% CI: 1.01-2.31, P=0.050). In addition, sixty-six cases (19.0%) developed grade ≥2 dermatitis, three SNPs that significantly associated with the risk of grade ≥2 dermatitis included GSDME rs2237314 (OR=0.36, 95% CI: 0.16-0.83, P=0.017), GSDME rs12540919 (OR=0.52, 95% CI: 0.27-0.99, P=0.045) and NLRP3 rs3806268 (OR=1.51, 95% CI: 1.03-2.22, P=0.037). There was no significant difference in the association between other genetic variations and AEs of rectal cancer patients (all P>0.05). Surgical procedure and tumor location had great impacts on the occurrence of grade ≥2 diarrhea and dermatitis (all P<0.01). Conclusion The genetic variants of CASP4, CASP11, GSDME and NLRP3 are associated with the occurrence of AEs in patients with rectal cancer who received postoperative CRT, suggesting they may be potential genetic markers in predicting the grade of AEs to achieve individualized treatment of rectal cancer. [ABSTRACT FROM AUTHOR]

Epidermal growth factor receptor （EGFR） is one of the primary therapeutic targets for metastatic colorectal cancer（mCRC）.However，primary or acquired resistance to anti-EGFR therapy has long been a crucial problem to be solved urgently.Abnormal activation of EGFR-related signaling pathways in tumor cells，genomic instability and genetic or epigenetic changes are the most common mechanism of resistance to anti-EGFR therapy. Meanwhile，recent evidences showed that alterations of cell abundance and cytokines in the tumor microenvironment are also closely related to anti-EGFR therapy resistance. In this review，we will summarize the research progress about the mechanism of resistance to anti-EGFR therapy in CRC from the aspects of both the tumor cell and tumor microenvironment. [ABSTRACT FROM AUTHOR]

During the long-term cycle use of amine solution, thermal degradation, chemical degradation and oxidative degradation will occur due to the influence of various factors, which will have adverse effects on the corrosion, foaming degree and desulfurization efficiency of the solvent. Among them, the thermal stable salts(HSS) produced by oxidative degradation has a great influence on the solvent, resulting in the aggravation of equipment corrosion, the increase of amine solution loss and the decrease of desulfurization efficiency. Therefore, in order to maintain the long-term stable and efficient operation of the device, it is necessary to remove the thermal stable salts in the desulfurizer. In this paper, the principles and characteristics of electrodialysis method to remove the heat stable salts were analyzed, and the heat stable salts removal facilities using electrodialysis method developed by Zhejiang Manatee Environmental Polytron Technologies Inc. was applied to CNOOC Zhoushan Petrochemical Co., Ltd, which was taken for example of removing heat stable salts from the system amine solution. The feasibility of the electrodialysis method to remove the heat stable salts in the industrial application was illustrated. Meanwhile, some questions and suggestions were put forward. [ABSTRACT FROM AUTHOR]

目的 观察调节型双通道空肠间置代胃术( a-OJI ) 对胃癌患者全胃切除术后近期血钙水平的影响。方 法选择行全胃切除术的胃癌患者60 例， 术中采用a-OJI 重建消化道35 例（ 观察组） 、Roux-en-Y 食管空肠吻合术 ( RY) 重建消化道25 例（ 对照组） ， 分别于术前及术后1 、3 、6 、9 、12 个月时检测血钙水平， 并将两组按年龄及性别进 行分层分析。结果与术前比较， 术后两组血钙水平均持续降低( P 均< 0. 05 ) ， 且观察组高于同时点对照组( P 均 < 0. 05 ) ， 但两组血钙总体水平仍处于正常范围。不同性别同年龄段两组血钙水平差异均无统计学意义， 同性别年 龄＞ 60 岁者观察组术后各时点血钙水平均高于对照组( P 均< 0. 05 ) 。结论相较于RY 消化道重建术， a－DJI 消 化道重建术对胃癌患者全胃切除术后近期血钙水平影响小； 术后血钙水平降低主要与年龄有关， 因此消化道重建 术后特别是老年患者需及时补钙。 [ABSTRACT FROM AUTHOR]

Changes of hydro-meteorological factors in the source region of the Yangtze River are a global concern. Pervious research focused on the temporal and spatial variation characteristics in hydro-meteorological factors. Research on the relationships between hydrometeorological factors and large- scale circulation in the source region of the Yangtze River is scarce. Based on the hydro- meteorological factors and large- scale atmospheric circulation factors in the source region of the Yangtze River, trends, volatilities and periodic changes of hydro-meteorology factors (precipitation, evapotranspiration and streamflow) during 1957-2012 were explored by using Mann- Kendall method, detrended fluctuation analysis method and wavelet analysis method. The relationships between hydro- meteorological factors and largescale atmospheric circulation factors were further studied. Meanwhile, the driving mechanism of large-scale atmospheric circulation on hydro-meteorological factors was disclosed by analyzing the water vapor flux in the source region of the Yangtze River. The results showed that climatic situations in the source region of the Yangtze River were basically characterized by warm and dry during 1990s. Since 2000s, the climatic turned to warm and wet. Time series of hydrometeorological factors in the source region of the Yangtze River had positive long- rang correlations. Climatic situation in the source region of the Yangtze River will keep warm and wet in the future. There were 1- 5 year, 10- 24 year and 25- 45 year periods of hydrometeorological factors in the source region of the Yangtze River. South Asian monsoon (SAM) is a relative important large- scale atmospheric circulation that can influence the precipitation and streamflow in the source region of the Yangtze River. It is mainly because the southwest vapor fluxes driven by the SAM are dominant source of vapor fluxes in the source region of the Yangtze River. [ABSTRACT FROM AUTHOR]

In order to carry out a precise and high-reliability design for the main shaft of MW wind turbine, a strength analysis and optimiza tion method was proposed based on WorkBench. Firstly, The finite element model of main shaft with accessories was established, a lamina model was used to simulate bearing, and the ultimate strength and fatigue strength of the main shaft were calculated according to IEC standard. Then the relevant design variables were defined and parameterized according to the hot spot's location, and the response surfaces model were built and analyzed by using the DOE method of LHS. To minimize the weight and equivalent stress, a multi-objective optimization algorithm was used to optimize and the results were verified. The results show that the mass of main shaft is reduced by 2% after optimization, the maximum stress is reduced by 8%, and the safety margin of fatigue increased by 16.56%. The reliability and economy of main shaft have been improved. [ABSTRACT FROM AUTHOR]

Objective:To explore the caller characteristics of psychological assistance hotline and changes over time during the COVID-19 epidemic. Methods: The calls of Jiangsu' s psychological assistance hotline during the COVID-19 epidemic from February 1, 2020 to April 30, 2020 were collected, and the contents of the calls were classified. The changes of the number of incoming calls over time were analyzed. Results: The number of calls related to COVID-19 was 1610, accounting for 23. 3 % of the total calls. The calls about COVID-19 included psychological problems ( emotional behavior problems caused by COVID-19, recurrence of original mental problems, and psychological problems at home), information consultation and other problems. Among psychological problems, the rate of recurrence of original mental problems was significantly higher in April than in February ( 15. 7 % vs. 5. 3 %, P < 0. 05). Conclusion: During the COVID-19 epidemic, the psychological assistance hotline calls mainly focused on psychological problems and information consultation. The number of calls decreased with the improvement of the epidemic situation. [ABSTRACT FROM AUTHOR]

Four kinds of film base and product were producted by adding different mesh of Calcium carbon­ate in paper-process reconstituted tobacco, whose physical and smoke indexes were tested. As the change of physical and smoke indexes of film base and product with the increase of Calcium carbonate mesh was analyzed. The results showed that physical indexes including tensile strength, burst strength, filling value and equilibrium moisture content of film base and product all presented an increasing trend except the bulk index declined. Overall, the effect of Calcium carbonate mesh on physical indexes of paper-process reconstituted tobacco was more remarkable than the film base. The smoke indexes testing results showed a higher Calcium carbonate mesh would lead to higher carbon monoxide, tar and total particulate matter in paper-process reconstituted tobacco and film base smoke, the effect of Calcium carbonate mesh on moisture, CO/tar ratio, the number of puffs and nicotine content in product smoke was smaller. In order to decrease the carbon monoxide content in product smoke, the mesh of Calcium carbonate should be smaller. The appropriate mesh was under 600 mesh. [ABSTRACT FROM AUTHOR]

BACKGROUND: Tendon derived stem cells exist in the tendon and have unique functions for tendon repair. Different cytokines have different effects on the proliferation and differentiation of tendon derived stem cells. Platelet-rich plasma refers to the blood product obtained from the whole blood through gradient centrifugation and stratification, which contains a variety of cytokines that could help to promote the regeneration of ligaments and tendons. OBJECTIVE: To investigate the latest progress of effects of cytokines and platelet-rich plasma on proliferation and differentiation of tendon derived stem cells. METHODS: Using “tendon derived stem cells, tendon stem/progenitor cells, tendon stem cell, platelet-rich plasma, ligament injury” as keywords in English and “tendon derived stem cells, platelet-rich plasma, ligament injury” in Chinese, the first author searched PubMed, CNKI, and Wanfang for relevant articles published from 2007 to 2019. Literature unrelated to the purpose of the study and repetitive literature were excluded, and 83 articles that meet the criteria were included for review.RESULTS AND CONCLUSION: Tendon derived stem cells are ideal cells for the treatment of tendon injury in cell transplantation. Its proliferation and differentiation are influenced by cytokines. Platelet-rich plasma contains a large number of cytokines, which can stimulate the proliferation and differentiation of tendon derived stem cells and have the potential to become a carrier of cell transplantation. Exploring the relationship between cytokines and proliferation and differentiation of tendon stem cells will provide a new approach for the clinical application of tendon derived stem cells. [ABSTRACT FROM AUTHOR]

Objective To investigate the associations between the genetic variations of apoptosis genes and the adverse events of postoperative concurrent chemoradiotherapy in patients with rectal cancer. Methods We enrolled 362 patients with stage Ⅱ to Ⅲ rectal cancer who received concurrent chemoradiotherapy. Whole blood sample (2 ml) was collected from patient at the time of enrollment before therapy. Sequenom MassARRAY was used to detect the genotypes of 29 haplotype-tagging single nucleotide polymorphisms (htSNPs) in eight apoptosis genes, including Fas cell surface death receptor(FAS), Fas ligand(FASL), apoptotic peptidase activating factor 1(APAF1), BCL2 associated X(BAX), TNF-related apoptosis-inducing ligand(TRAIL), TNF-related apoptosis-inducing ligand receptor 1(TRAILR1), TNF-related apoptosis-inducing ligand receptor 2(TRAILR2) and caspase-7(CASP7). The associations between genotypes and adverse events of chemoradiotherapy were measured by unconditional logistic regression model. Results Three hundred and sixty two patients were treated with total mesorectal excision surgery followed by a total radiation dose of 50 Gy applied in 25 fractions over a period of 5 weeks concurrently with daily administration of capecitabine (1 600 mg/m² per day, continuously for 2 weeks and taking a week off every 21-day cycle). One hundred and six patients (29.3%) had grade≥2 myelosuppression. Three SNPs associated with the risk of grade ≥2 myelosuppression included FAS rs1468063 (OR=1.51, 95% CI: 1.07-2.15, P=0.020), APAF1 rs11296996 (OR=0.69, 95% CI: 0.49-0.98, P=0.039) and BAX rs4645904 (OR=0.69, 95% CI: 0.50-0.97, P=0.030). One hundred and sixty one patients (44.5%) developed grade≥2 diarrhea. Five SNPs that significantly associated with risk of grade≥2 diarrhea included APAF1 rs11296996 (OR=1.42, 95% CI: 1.02-2.00, P=0.040), rs74619561 (OR=2.16, 95% CI: 1.27-3.68, P=0.005), CASP7 rs12263370 (OR=1.67, 95% CI: 1.05-2.66, P=0.029), rs12247479 (OR=1.85, 95% CI: 1.12-3.08, P=0.017) and TRAIL rs112822654 (OR=0.68, 95% CI: 0.48-0.96, P=0.027). The remaining SNPs were not related to the adverse events of chemoradiotherapy (all P>0.05). Grade≥2 myelosuppression occurred less frequently in male than in female (P=0.046); Surgical treatment and tumor location had great impact on the occurrence of grade≥2 diarrhea (all P<0.001) and dermatitis (all P<0.05). Conclusions The genetic variations of FAS, APAF1, BAX, TRAIL and CASP7 are related to the adverse events of concurrent chemoradiotherapy in patients with rectal cancer, which may be potential genetic biomarkers for individualized treatment of rectal cancer. [ABSTRACT FROM AUTHOR]

In this paper, we studied several numerical calculation problems in submerged floating tunnel (SFT) covering simulation method and necessity of tube torsion, finite-element division length, necessity of geometric nonlinearity, structural damping, water damping, added-water-mass-coefficient and finite element type selection for cable in terms of engineering parameters impact, calculation efficiency, design risk and acceptable tolerances. Main findings are: 1) the necessity of modeling torsion effect of tube of SFT depends on its cross-section's outline geometry character, width-height-ratio, mooring cable length, and transverse arrangement of cable; 2) the necessity for using geometry-nonlinear algorithm, which costs more computational efforts, is in positive correlation with the degree of load on tube as well as height-length ratio; 3) in most cases the assumption of constant water damping in overall structural dynamic analysis can satisfy the accuracy of engineering problem. [ABSTRACT FROM AUTHOR]

Submerged floating tunnel sectional model research methods normally are flume physical model test, mathematical modeling or both thereof. We pointed out that the exiting studies have neglected or ignored the stiffness contribution of tube and shore connections, this unreal boundary setting of section model would impact the practical engineering use and guide value of research outcrops. In this paper, the principle and quick calculation formula for deriving section's real stiffness were provided; then configuration of improved flume test with real stiffness were proposed; finally, the need for a numerical tool to link the results of real stiffness section model research results and the three-dimensional overall structural analysis were conceived, and the first-step attempts of using wake oscillators to simulate section's vortex induced motion derived from both physical tests and CFD calculations. [ABSTRACT FROM AUTHOR]