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Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore pathogenesis, characteristic genes and immune infiltration of rheumatoid arthritis (RA) by bioinformatics and machine learning methods, and to find correlation between characteristic genes and immune cells. Methods: Chips related to RA were obtained from GEO database, gene differences were analyzed by R language, and GO and KEGG were enriched and analyzed; machine learning methods, namely LASSO regression and SVM-RFE were used to screen disease characteristic genes, ROC curve and sample chips were used to detect accuracy of characteristic genes, CIBERPORT algorithm was used to analyze immune infiltration of RA, and correlation between characteristic genes and immune cells was analyzed. Results: A total of 90 differential genes were obtained from GSE12021 and GSE55235, including 64 up-regulated and 26 down-regulated differentially expressed genes. A total of 209 main items were obtained by GO analysis, mainly involving leukocyte activation, lymphocyte activation, B-cell receptor signaling pathway, etc; KEGG analysis showed that chemokine signaling pathway, IL-17 signaling pathway, Toll-like receptor signaling pathway and PPAR signaling pathway were closely related to RA; ten key genes such as IGHM, SLAMF8, CXCL10, FNDC4, AIM2, EGR1 and AKR1B10 were screened by mechanical learning method. Disease characteristic genes were IGHM, SLAMF8, CXCL10, AIM2 and AKR1B10 by ROC curve and sample chip; immune infiltration results showed that there were significant differences between synovial tissues of RA and normal tissues in 9 kinds of immune cells, such as plasma cells, CD8 T cell, CD4 T cell and T cell follicle helper. By analyzing correlation between disease characteristic genes and immune cells, it was found that there were significant correlations between 5 characteristic genes and some immune cells. Conclusion: There is a significant correlation between characteristic genes and immune cells of RA, which provides a preliminary basis for follow-up in-depth study of targeted diagnosis and treatment of RA. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Nanjing Agricultural University / Nanjuing Nongye Daxue Xuebao is the property of Journal of Nanjing Agricultural University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Osteoporosis（ OP） is an orthopedic disease characterized by decreased bone mass, decreased bone mineral density, damaged bone microstructure, and multiple fractures. At present, western medicine is the main treatment for OP, but the curative effect is not ideal. Therefore, it is necessary to find a drug treatment scheme to cure OP. With the development of traditional medicine research on OP, we find that icariin can promote bone formation, improve bone metabolism balance, and increase bone mineral density through MAPK signaling pathway, thus playing an anti-OP role. Therefore, we combine icariin and MAPK signaling pathway to promote osteoblast proliferation and differentiation, to inhibit osteoclast differentiation, and to promote osteogenic differentiation of bone marrow mesenchymal stem cells. The research progress of icariin mediated MAPK signaling pathway in the prevention and treatment of osteoporosis is reviewed in order to provide new ideas for clinical treatment of OP in the future. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Wuling power has an effective effect in the clinical treatment of knee arthritis, but its pharmacological effects, but its molecular mechanisms and drug active components are not yet clear. OBJECTIVE: Based on the network pharmacology method, the potential molecular mechanism of Wuling powder in the treatment of osteoarthritis was explored, and the role of these molecules and related signaling pathways was elaborated, providing a theoretical basis for further extraction of key drug compounds. METHODS: TCMSP was used to screen the active components and corresponding targets of Wuling powder, and Gene Cards, OMIM and DigSee disease databases were integrated to obtain the related targets of osteoarthritis. The potential targets of Wuling powder in the treatment of osteoarthritis were obtained by mapping and intersection on the Venny platform. The network of “single drug-active component-interaction target” and protein-protein interaction network of Wuling powder in the treatment of osteoarthritis were constructed by using the software of Cytoscape, and the functional enrichment analysis of GO and the enrichment analysis of KEGG pathway of Wuling powder in the treatment of osteoarthritis were carried out by using David database. Finally, the key active components and key targets of Wuling powder were verified through molecular docking by using PyMOL and other software. RESULTS AND CONCLUSION: A total of 52 active ingredients including β-sitosterol, catechin and taxifolin were screened. The protein-protein interaction analysis indicated that there were 26 key targets of Wuling powder in the treatment of osteoarthritis, including estrogen receptor 1 (ESR1), which can promote the proliferation of chondrocytes and inhibit the expression of related inflammatory cytokines, tumor protein p53 (tumor protein), which is involved in the inflammatory reaction of osteoarthritis p53, and ubiquitin ligase CUL3 (cullin3) that mediates apoptosis. The results of molecular docking showed that catechin with the lowest affinity and NTRK1 had a good molecular docking, indicating that the predicted key active components of Wuling powder have a good binding activity with the key targets of osteoarthritis treatment. There were 709 GO items in total, including 649 biological processes, 22 cell components and 38 molecular functions, which are mainly involved in the response to estrogen, inflammation and lipopolysaccharide. KEGG pathway enrichment analysis showed that the related pathways of key protein modules included AGE-RAGE signaling pathway, interleukin-17 signaling pathway, tumor necrosis factor signaling pathway, p53 signaling pathway, and estrogen signaling pathway, which are involved in the process of oxidative stress, inflammatory response and apoptosis of chondrocytes. The results showed that the active compounds β-sitosterol, catechin, taxifolin and hederagenin in Wuling powder could regulate relevant signaling pathways by regulating the expression of ESR1, TP53, CUL3 and MCM2 related protein targets, which can slow down the apoptosis of chondrocytes, strengthen the proliferation and repair of chondrocytes, and reduce the inflammatory response. [ABSTRACT FROM AUTHOR]

BACKGROUND: Shengyu Decoction can be used to treat osteonecrosis of the femoral head (ONFH), but its mechanism is unknown. OBJECTIVE: To explore the molecular mechanism of Shengyu Decoction in treating ONFH based on network pharmacology and molecular docking technology. METHODS: The active components and corresponding targets of Shengyu Decoction was screened by TCMSP database. The related targets of ONFH were obtained by the query results of GEO chip, OMIM and Gene Cards databases. The potential targets of Shengyu Decoction in the treatment of ONFH were obtained by mapping intersection by Venny platform. The network of “single drug-active target-potential target” and protein-protein interaction network of Shengyu Decoction in the treatment of ONFH were constructed by Cytoscape software. The action targets of Shengyu Decoction were analyzed by David database through the gene ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Autodock vina software was used to carry out molecular docking between key effective components and important targets, followed by the assessment of their binding activity. RESULTS AND CONCLUSION: A total of 66 active ingredients and 196 targets of Shengyu Decoction and 6 045 related targets of ONFH were screened out, and 73 intersected targets of Shengyu Decoction in the treatment of ONFH were obtained. The “single drug-active ingredient-target” network indicated that the main active ingredients were kaempferol, quercetin, β-sitosterol, stigmasterol, isorhamnetin, etc. Protein-protein interaction analysis showed that the main core targets were interleukin-6, vascular endothelial growth factor A, matrix metalloproteinase-9, etc. The GO functional enrichment analysis yielded 804 entries (P < 0.01), mainly involving oxidative stress response, angiogenesis regulation, cell cycle regulation, immune response, inflammatory factors, etc. The KEGG pathway enrichment analysis obtained 120 pathways, mainly involving hypoxia-inducible factor-1α signaling pathway, interleukin-17 signaling pathway, tumor necrosis factor signaling pathway, nuclear factor-κB signaling pathway, Toll-like receptor signaling pathway and other pathways related to inflammatory response, angiogenesis and immune regulation. Molecular docking results showed that the binding energies of the five core target proteins and the five main active components were far less than the reference values, indicating that the main active components are stably bound to the core target receptor proteins. To conclude, Shengyu Decoction can participate in the regulation of immune-inflammatory responses, bone metabolism, angiogenesis, and oxidative stress through the active components such as kaempferol, quercetin, β-sitosterol, stigmasterol, and isorhamnetin, thereby playing a role in the treatment of ONFH. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Nanjing Agricultural University / Nanjuing Nongye Daxue Xuebao is the property of Journal of Nanjing Agricultural University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: In recent years, with the deepening of medical research, it has been found that PI3K/AKT signaling pathway has a regulatory effect on vascular repair regeneration, osteoblast differentiation and proliferation, and osteoclast bone differentiation. This is very important for the treatment of femoral head necrosis. OBJECTIVE: To provide a brief overview of the main research progress in mechanisms of PI3K/AKT signaling pathway regulating femoral head necrosis in recent years, aiming to provide new ideas for the treatment of osteonecrosis of the femoral head in the future. METHODS: PubMed and MEDLINE database, Wanfang, CNKI, WIPO and CBM database were searched from 2012 to 2019, for relevant domestic and foreign literatures, including: (1) epidemiological study of osteonecrosis of the femoral head and related pathogenesis; (2) PI3K/AKT pathway related mechanism; (3) research literature on the effects of PI3K/AKT on factors related to vascular repair and regeneration; (4) research literature on the regulation of PI3K/AKT on osteoblast differentiation and proliferation-related factors; (5) literature on the regulation of PI3K/AKT on functional factors related to osteoclast differentiation. A total of 62 literatures were included for analysis and summary. RESULTS AND CONCLUSION: (1) The PI3K/AKT signaling pathway has been proven to be effective in the regulation of vascular repair regeneration, osteoblast differentiation, proliferation, apoptosis and osteoclast differentiation. After understanding these pathways, research and development of related drugs to improve the success rate of early conservative treatment of osteonecrosis of the femoral head have great development prospects and potential, opening up a new path for future orthopedic surgeons to treat osteonecrosis of the femoral head, and bringing new hope to patients and their families. (2) According to the different osteonecrosis of the femoral head conditions of patients, how to use PI3K/AKT signaling pathway to guide treatment becomes a breakthrough point and challenge of this technology, and more research is needed later. [ABSTRACT FROM AUTHOR]

BACKGROUND: With the continuous improvement of modern technology and medical level, although there are many ways to treat infectious bone defects, there is a lack of a viable early treatment regimen that combines anti-inflammatory, fracture healing, and biodegradable therapies, for the purpose of primary treatment measures. This is also the goal and motivation of future medical workers. OBJECTIVE: To investigate the application and prospect of bone tissue engineering in the treatment of infectious bone defects. METHODS: PubMed and MEDLINE database, WanFang, CNKI, VIP and CBM database were searched from 2013 to 2019 for relevant domestic and foreign literatures, including: (1) clinical application and research literature of local antibiotics; (2) experimental study on sustained release system (DDS) for the treatment of bone infection; (3) clinical and experimental literature on biological scaffold materials in large bone defects; (4) application and progress of bone tissue engineering in the repair of infectious bone defects; (5) literature on 3D printing technology. A total of 60 literature analyses and summaries were included. RESULTS AND CONCLUSION: (1) The local use of antibiotics at bone infection site was effective. (2) Bone tissue engineering had a great development prospect and potential in inducing bone regeneration to repair bone defects, which also pointed out a new way for orthopedic surgeons to treat infectious bone defects in the future, and gave new hope to patients and their families. The breakthrough and challenge of this technology is to explore the most suitable high-quality cells. (3) To explore the perfect combination of bone tissue engineering technology, antimicrobial agents and absorbable biomaterials for the treatment of infectious bone defects with new technologies is a new development direction of the orthopedic clinical treatment for infectious bone defect in the future. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To analyze the prognosis and related factors of hip replacement in elderly patients with osteoporosis, and to provide evidence for improving the prognosis of elderly patients with osteoporosis. Methods According to the prognosis, 154 cases of elderly patients with osteoporosis who underwent hip replacement from January 2015 to December 2017 were divided into observation group (poor prognosis) and control group (good prognosis). The related data of the two groups were compared retrospectively, and the factors affecting the prognosis were analyzed using logistic multivariate regression. Results The prognosis was good in 121 cases at 6 months after operation with a good prognosis rate of 78.57%. The proportion of BMI of 27 - 35kg/m2, rehabilitation intervention time (7 d),and postoperative complications in the observation group were significantly higher than those in the control group , postoperative use of oral vitamin D were significantly lower than that in the control group (P<0.05). The bone mineral density and serum levels of PTH and BLAP in the observation group were (-3.04±0.36), (30.65±3.98) μg/mL, and（42.13±5.27）μg/L, respectively. The above values were (-2.73±0.20), (25.76±3.32) μg/mL, and（34.95±4.32）μg/L, respectively, in the control group (P<0.05). Logistic regression analysis showed that high BMI and low bone mineral density were independent risk factors for poor prognosis after hip replacement, and rehabilitation intervention time was a protective factor. Conclusion There are many influencing factors for the prognosis of hip replacement in elderly patients with osteoporosis. The independent risk factors include high BMI and low bone mineral density. Early postoperative rehabilitation training can improve prognosis. [ABSTRACT FROM AUTHOR]

BACKGROUND: Nonunion and delayed union of fractures not only cause great troubles to individuals and families, but bring huge financial burden to the society. The optimal fracture treatment requires understanding of the complex physiological process of fracture healing. OBJECTIVE: To explore and compare the fracture healing mechanism by reviewing the relevant literature, so as to provide new idea for clinical diagnosis and treatment. METHODS: CNKI, WanFang, VIP and PubMed databases were retrieved with the keywords of “fracture healing, nonunion, inflammation, signaling pathways, osteoclasts, osteoblast, BMP, Wnt, Hedgehog, PTH” in Chinese and English, respectively. The articles concerning the molecular/signaling pathway/cell of fracture healing mechanism, the repetitive studies were excluded, and finally 46 eligible articles were enrolled for analysis. RESULTS AND CONCLUSION: (1) By summarizing and discussing the mechanism of fracture healing from the aspects of inflammation stage, signal pathway and cell, we found that the contradiction between clinical and early scientific research (such as adverse reactions) can be unified in deep research. (2) However, the current research results cannot solve all clinical problems due to the complicated mechanisms of fracture healing. (3) The interaction between different molecules makes it difficult to find a clinically significant marker for the clinical diagnosis of early nonunion. (4) It is necessary to develop more sophisticated experimental equipment and design more rigorous scientific research programs to serve the clinical practice. (5) However, according to the current research results, we can consider cooperating with biomimetic delivery of signals for bone tissue engineering to make the original isolated, planar and static research results have three-dimensional dynamics more in line with the clinical treatment needs, which is the future direction. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Nanjing Agricultural University / Nanjuing Nongye Daxue Xuebao is the property of Journal of Nanjing Agricultural University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Preliminary studies have shown that panax notoginseng saponins can promote the repair of osteocyte ultrastructure in a rabbit with alcohol-induced osteonecrosis of the femoral head. OBJECTIVE: To observe the structural changes of osteocytes in a rabbit with steroid-induced osteonecrosis of the femoral head treated with panax notoginseng saponins by transmission electron microscope. METHODS: Ninety 9-10 weeks old healthy male New Zealand rabbits (provided by Laboratory Center of Guangxi University of Chinese Medicine), weighting 3.5-4.0 kg were selected. Rabbit models of steroid-induced osteonecrosis of the femoral head were established by injecting modified horse serum combined with methylprednisolone sodium succinate. Fifteen rabbits died, so the remaining 75 rabbits were divided into three groups (n=25 per group), and then treated with normal saline, cervus and cucumis polypeptide or panax notoginseng saponins, respectively for 5 weeks. The structural changes of osteocytes were observed under transmission electron microscope. RESULTS AND CONCLUSION: In the normal saline group, the number of mature osteocytes was reduced, vascular endothelial cells were damaged, and mitochondria swelling, fuzzy cristae structure, nuclear fragmentation, and lipid droplets were observed. In the cervus and cucumis polypeptide and panax notoginseng saponins groups, there were more mature osteocytes and less vascular endothelial cell damage, swollen mitochondria alleviated with clear structure, and the numbers of mast adocytes and lipid droplets were decreased. The structural changes of osteocytes in the cervus and cucumis polypeptide and panax notoginseng saponins groups were significantly more encouraging than those in the normal saline group (P < 0.05). Our results indicate that show that, panax notoginseng saponins can repair the osteocyte structure of rabbits with steroid-induced osteonecrosis of the femoral head. [ABSTRACT FROM AUTHOR]

BACKGROUND: Since the Urist et al. from the USA found that bone morphogenetic proteins contribute to bone regrowth in 1965, bone induction has been a hot spot worldwide. In recent years, the study on bone morphogenetic proteins in China has also entered the clinical trial stage.OBJECTIVE: To review the clinical application and research progress of bone morphogenetic proteins in bone and cartilage tissue engineering.METHODS: "Bone morphogenetic protein, bone tissue engineering, cartilage tissue engineering, osteoarthritis, fracture, nonunion, bone defect, osteonecrosis of femoral head, gene therapy" in English and Chinese, respectively were used as keywords. The first author retrieved the literature concerning the clinical application of bone morphogenetic proteins in bone and cartilage in Pub Med, Medline, Embase, CNKI,WanF ang, and VIP databases from 2000 to 2018. A total of 62 eligible articles were included after excluding repeated studies.RESULTS AND CONCLUSION: From five aspects including arthritis, fracture, bone nonunion, bone defect; femoral head necrosis and gene therapy, clinical researches and outcomes of BMPs in bone and cartilage tissue engineering are summarized. Bone morphogenetic proteins possess strong bone-inducing active osteogenic factor, which can not only promote bone growth, but also promote the repair of cartilage, tendons and ligaments. Because of its high effectiveness and safety, it has been highly regarded in recent years. A variety of transforming growth factors mutually applied in bone and cartilage tissue engineering will become a hot spot in orthopedic research, which needs further investigation. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: With the increasing number of patients undergoing knee arthroplasty in China, the complications caused by the mismatch of prosthesis with anatomical parameters arouse extensive attentions. OBJECTIVE: To measure the anatomical parameters of the knee joints in healthy Zhuang ethnic group from Guangxi Zhuang Autonomous Region, China, using three-dimensional (3D) reconstruction technology, thus providing reference for the design and placement of the hip prosthesis. METHODS: Sixty-eight individuals, including 30 females and 38 males, were selected from 217 healthy people undergoing CT examination. All data were imported into Mimics 15.0 software used for 3D reconstruction, and then the knee parameters were then measured and analyzed. RESULTS AND CONCLUSION: There was no significant difference in the parameters of the bilateral femur and tibia (P > 0.05). The femoral parameters had significant differences between genders (P < 0.05). The width of tibial platform, sagittal length of lateral tibial platform, distance between medial tibial plateau and fibular head, and posterior slope of tibial plateau showed no significant differences between genders (P > 0.05), while there were significant differences in the width of medial/lateral tibial platform, and sagittal length of medial tibial platform between genders (P < 0.05). The sagittal length of medial femoral condyle was negatively correlated with age, and all femoral parameters were positively correlated with height; while only the width of medial and lateral tibial platform were positively correlated with height. To conclude, 3D reconstruction technology is available for research on the morphology of the knee joint in the Zhuang ethnic group from Guangxi Zhuang Autonomous Region, which provides references for prosthesis design and research appropriate for the Zhuang ethnic group. [ABSTRACT FROM AUTHOR]

BACKGROUND: A silk fibroin/chitosan scaffold has good biocompatibility, osteoinductivity and degradability. OBJECTIVE: To review the structure, performance and application of the silk fibroin/chitosan scaffold in bone, cartilage and soft tissue engineering regeneration. METHODS: PubMed, Wanfang, and CNKI databases were retrieved by computer for articles related to the structure, performance and application of the silk fibroin/chitosan scaffold in orthopedics published from 1998 to 2016. The keywords were “chitosan, silk protein, bone tissue engineering” in English and Chinese, respectively. RESULTS AND CONCLUSION: The silk fibroin/chitosan scaffold is characterized by good biocompatibility, bone inductivity and biodegradability that make cells grow well on the scaffold. The silk fibroin/chitosan scaffold has been widely used in bone tissue engineering, and has a prominent performance in bone defect repair and cartilage injury treatment. Meanwhile, the silk fibroin/chitosan scaffold exerts a crucial role in wound healing as well as in the treatment of spinal nerve injury and other soft tissue injuries. However, the silk fibroin/chitosan scaffold currently is less reported in the clinical use due to various reasons, and it will be the main research direction of future efforts. As is known to us, silk protein can be used to prepare the cruciate ligament and construct tissue-engineered nuclei; therefore, the silk fibroin/chitosan scaffold can be developed in the treatment of tendon ligament injury and intervertebral disc tissue engineering. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective This study analyzes anatomical parameters of the hip in healthy people in Guangxi Zhuang Autonomous Region, in order to provide evidence for the design and placement of the hip prosthesis. Methods One hundred people were selected from 327 healthy people who were performed CT scans in our hospital, including 48 females and 52 males. The images were imported into Mimics 15. 0 to perform 3D reconstruction and to analyze the parameters impacted to the hip arthroplasty. The data were compared with other results from national and international studies. Results The measurement results for the relevant parameters of the hip showed that SID was 55. 38 ± 2. 76, AD was 58. 73 ± 4. 40, CE was 39. 41 ± 5. 64, AI was 14. 75 ± 3. 20, ABA was 49. 76 ± 4. 98, Sharp angle was 37. 20 ± 3. 75, AVA was 37. 20 ± 3. 75, ADD was 10. 45 ± 2. 22, AHI was 84. 90 ±3. 20, NSA was 127. 67 ± 4. 13, FNA was 13. 98 ± 0. 78, FHD was 43. 80 ± 4. 63, FHH was 30. 32 ± 4. 90, FND was 34. 04 ±3. 25, FCL was 46. 11 ± 5. 32, and FO was 38. 55 ± 4. 62, respectively. The medial-lateral diameter of bone medullary cavity at the plane of 20 mm above was 41. 98 ± 3. 02, midpoint was 25. 95 ± 2. 42, and 20 mm below the lesser trochanter was 19. 86 ± 1. 46, respectively. The internal of the isthmus was 9. 83 ± 1. 15 and external of the isthmus diameter was 26. 69 ± 2. 05. The results showed that there were significant differences of most parameters of the hip between two genders and between the left and right except AHI, NSA, 20 mm below the lesser trochanter, and internal of the isthmus. Conclusion There are differences of hip joint parameters between healthy people in Guangxi Zhuang Autonomous Region and other areas. Compared with other published data, CE angle is the most different, internal diameter of isthmus is smaller, and the morphology of the proximal femur partial is smaller. [ABSTRACT FROM AUTHOR]