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Objective: To explore the relationship study between serum myelin basic protein (MBP), lactate dehydrogenase (LDH) to albumin (ALB) ratio (LAR), ALB to globulin (GLB) ratio (AGR) and postoperative brain injury and prognosis in patients with glioma. Methods: 90 cases of patients with glioma who received surgical treatment admitted to Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical University from January 2017 to June 2019 were retrospectively selected, and they were divided into mild brain injury group with 51 cases, moderate brain injury group with 24 cases and severe brain injury group with 15 cases according to the score of the Glasgow Coma Scale (GCS) after surgery. After 3 years of follow-up, they were divided into death group and survival group according to the prognosis. Clinical data were collected, and serum MBP, LAR and AGR before surgery were detected. Spearman correlation was used to analyze the correlation between GCS score and serum MBP, LAR and AGR in patients with glioma, and multivariate logistic regression was used to analyze the influencing factors of death in patients with glioma. Results: Serum MBP and LAR in the mild, moderate and severe brain injury groups were increased successively, while AGR was decreased successively (P< 0.05). Spearman correlation analysis showed that postoperative GCS score in patients with glioma was negatively correlated with serum MBP and LAR, and positively correlated with AGR (all P<0.05). After 3 years of follow-up, the mortality rate of 90 cases of patients with glioma was 35.56% (32/90). Multivariate logistic regression analysis showed that World Health Organization (WHO) grade III, incomplete resection range, decreased postoperative GCS score and elevated MBP and LAR were the independent risk factors for death in patients with glioma, and elevated AGR was the independent protective factor (P<0.05). Conclusion: Serum MBP, LAR and AGR in patients with glioma are closely related to postoperative brain injury and poor prognosis, which may be used as indicators to evaluate postoperative brain injury and prognosis in patients with glioma. [ABSTRACT FROM AUTHOR]

Objective To explore the correlation between the loss of expression of alpha thalassemia with mental retardation syndrome gene (ATRX) and over expression of P53 in patients with glioma and to analyze the clinical significance of the two gene expression and multi-factors in the diagnosis and prognosis of glioma. Method The clinical data of 92 patients were collected, including 30 patients with astrocytoma of grade Ⅱ/Ⅲ (WHO), 50 with oligodendroglioma of grade Ⅱ/Ⅲ (WHO) and 12 with glioblastoma of grade Ⅳ (WHO). The Chi-square test was applied to analyze the relationship between the two gene expression and different pathological types of glioma. The Spearman’s rank correlation analysis was used to analyze the correlation between their different expression. Kaplan-Meier survival curve was designed to investigate the clinical value of their different expression in prognosis of patients with glioma. The other contributing factors were analyzed in the multivariate Cox regression analysis. Results There was a correlation between the different expression of ATRX and P53 and the pathological types of glioma (P＜0.05). The correlation analysis showed that the loss of expression of ATRX and over expression of P53 in glioma were negative correlated (r=0.426,P＜0.01). The multivariate analysis showed that the age over 60 years old, grade Ⅲ/Ⅳ (WHO), preoperative KPS scores below 60 points, lack of postoperative radiotherapy and chemotherapy, and lost expression of the ATRX were independently risk factors for poor prognosis. Conclusion In patients with glioma, the loss of expression of ATRX and over expression of P53 were closely related to one another, and they together with other clinical factors can better evaluate the prognosis of glioma patients. [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical, imaging findings and diagnosis and treatment experience of choroid plexus carcinoma（CPC） in children. Methods The clinical data of a child with CPC were analyzed retrospectively, and the relevant literature was reviewed. Results The patient, male, was admitted to the hospital for “left ventricular tumor” due to “sudden convulsion for 3 days”. After admission, the relevant examinations were improved, and the tumor was resected through the lateral ventricular triangle approach at a selected time. The postoperative pathological diagnosis was CPC. The results of literature review showed that papillary carcinoma of the choroid plexus in children was a relatively rare tumor of the central nervous system, and it was difficult to diagnose. Conclusions Clinical manifestations, imaging features and pathological features are the major basis for the diagnosis of this disease. Surgical operation is the first choice of treatment at present. Radiotherapy has certain curative effect. [ABSTRACT FROM AUTHOR]

Objective To explore the clinical characteristics of tuberous sclerosis comlex( TSC) combined with subependymal giant cell astrocytoma( SEGA). Method The clinical data of 1 patient of TSC combined with SEGA were analyzed retrospectively. Results The case was diagnosed as tuberous sclerosis,the pathological diagnosis of the brain tumor was SEGA. The recovery was good after surgical resection of the tumor. Conclusions Tuberous sclerosis can combine with subependymal giant cell astrocytoma. Surgical resection of the tumor is an effective treatment for SEGA. [ABSTRACT FROM AUTHOR]

Objective To report one case of syringomyelia (SM) combined with Charcot joint disease (CJ) , further improving diagnosis and treatment of the disease by the method of literature review. Method By reviewing the clinical features of the disease and the typical imaging features, in combination with related literature in order to improve diagnostic accuracy. Results The clinical diagnosis of the patient's left elbow sickness is the typical Charcot joint disease, the case is diagnosed as syringomyelia caused Chiari malformation by cervical spine MRI. Conclusion Clinical and radiological features is a major basis for diagnosis of the disease. There is currently no effective treatment but surgery has certain curative effect. [ABSTRACT FROM AUTHOR]

Objective: To explore the relationship between hemoglobin to red blood cell distribution width ratio (HRR), platelet to lymphocyte ratio (PLR), and short-term mortality of patients with moderate to severe traumatic brain injury (TBI) . Methods: The medical records of 162 patients with moderate to severe TBI who were admitted to Xuzhou Medical University Affiliated Hospital from September 2019 to September 2021 were retrospectively collected, and the patients were divided into death group and survival group based on their survival status within 30d of admission. The HRR and PLR were calculated, the influencing factors of short-term mortality of patients with moderate to severe TBI was analysed by multivariate Logistic regression, and the predictive value of the Glasgow Coma Scale (GCS) scores combined with HRR and PLR for short-term mortality of patients with moderate to severe TBI was analysed by the receiver operating characteristic (ROC) curve. Results: The mortality rate of 162 patients with moderate to severe TBI within 30 d of admission was 35.80% (58/162) . Compared with the survival group, the HRR decreased and PLR increased of the death group (P＜0.05) .The multivariate Logistic regression analysis showed that GCS scores less than 9 scores, dilated pupils, brain hernia, HRR decreased and PLR increased were independent risk factors for short-term mortality of patients with moderate to severe TBI (P＜0.05) . The ROC curve analysis showed that the area under the curve for predicted short-term mortality of patients with moderate to severe TBI by HRR and PLR combined with GCS scores was the largest, which was 0.924. Conclusion: HRR decrease and PLR increase are associated with short-term mortality of patients with moderate to severe TBI, which may become an auxiliary predictor of short-term mortality of patients with moderate to severe TBI, combining with HRR and PLR on the basis of GCS scores can enhance the predictive value of short-term mortality of patients with moderate to severe TBI. [ABSTRACT FROM AUTHOR]