Search

Recent studies found that the intestinal flora is involved in the occurrence and development of CRC. In particular, Ruminococcus shows a decreased abundance in patients with CRC and can affect gastrointestinal health through cross-feeding and promoting butyrate production. Although the research on Ruminococcus is gradually increasing, no unified understanding of its influence on the occurrence and development of CRC has been established. This work summarizes the relationship of Ruminococcus with CRC and its possible anticancer mechanism to provide a theoretical basis for the further exploration of biological prevention and treatment of CRC in the future. [ABSTRACT FROM AUTHOR]

Fecal microbiota transplantation (FMT) has a unique therapeutic effect on a variety of diseases, and its common therapeutic approaches mainly include oral administration, nasointestinal tube, colonoscopy, enema and etc. Among them, because of its convenience in taking, the injury of taking oral administration multiple times is relatively small. But oral fecal bacteria will affect the FMT effect if it disintegrates in the stomach or small intestine. Colon targeted drug delivery system (CTDDS) enables drugs to act on the colon more accurately, which can improve the therapeutic effect and reduce the adverse reactions. In addition to the traditional pH-sensitive, time-delayed, enzyme-triggered, pressure-dependent and so on, CTDDS has developed into magnetic-driven, ligand (acceptor) -mediated, nano-drug and so on with the deepening of research. In recent years, some studies have combined them and used CTDDS to carry out FMT, which has achieved certain effects. This paper systematically introduces the application of CTDDS in FMT. [ABSTRACT FROM AUTHOR]

盆底功能障碍性疾病(PFD)是由于盆底支持结构薄弱、缺损及功能障碍等原因引起的一系列 盆底功能性疾病的总称。目前,PFD发病率逐年增高,最常见于中老年经产妇,起病隐匿,易迁延不愈,严重影 响了患者的生活质量。对 PFD 的治疗方式分为保守治疗和手术治疗,该文将对 PFD 的各种治疗方式进行 综述。 [ABSTRACT FROM AUTHOR]

Colorectal cancer is one of the top three malignant tumors in the world. With the rapid development of medical technology and the strengthening of national awareness of cancer screening, rectal cancer has been diagnosed and treated timely. At present, the application of low rectal tumor preservation operation is becoming more and more common. Anastomotic leakage and anterior resection syndrome are the most common complications of low rectal cancer. How to preserve anal and reduce the incidence of complications has always been the concern of scholars at home and abroad. In order to improve the survival time and quality of life of patients with low rectal cancer, this paper expounds five key problems: fully preoperative evaluation of anorectal function and staging, reasonable neoadjuvant therapy, safe distal margin, the selection of surgical methods and the timing of preventive stoma. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Beijing University of Traditional Chinese Medicine is the property of Journal of Beijing University of Traditional Chinese Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To prepare the nano-crystalline of oridonin and to investigate the effect on the proliferation and apoptosis of colorectal cancer cells. Methods The contents of oridonin nanosuspensions were prepared by high pressure homogenization. The nano-crystalline of oridonin was obtained after adding 5% mannitol, and then shaking and lyophilizing.The solubility was determined in vitro.Colorectal cancer cells (Lovo cells, SW480 cells, HCT-116 cells and HCT-8 cells) were cultured in vitro and incubated with different concentrations of nano-crystalline of oridonin (0, 5, 10, 15 and 25 μg/mL) . Cell proliferation was detected by cytometry. The apoptosis and cell cycle of cultured cells in different concentrations of nano-crystalline of oridonin (5, 10 and 25 μg/mL) were detected. Results The nanosuspensions and nano-crystalline of oridonin was prepared successfully.There were significant differences in the proliferation inhibition rate among four kinds of colorectal cancer cells that were intervened by different concentrations of nano-crystalline of oridonin for 24 h and 72 h (all P<0.05 ) .The nano-crystalline of oridonin with concentration of 25 μg/mL had the strongest inhibitory effect on cell proliferation as compared with the others (all P<0.05). The nano-crystalline of oridonin could block cell cy-cle of the Lovo cells and HCT-8 cells at G1 phase, and block the HCT-16 and SW480 cell cycle at S phase. Conclusion The vitro dissolution of nano-crystalline of oridonin is higher than oridonin. The nano-crystalline of oridonin can significantly inhibit the proliferation, induce the apoptosis and block the cell cycle of four kinds of colorectal cancer cells. [ABSTRACT FROM AUTHOR]