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目的探究肌球蛋白重链7基因来源的微小RNA-208b-3p（miR-208b-3p）对心肌成纤维细胞纤维化表型的调控作用。方法通过miRNA 表达谱芯片分析18周龄的糖尿病db/db小鼠和db/m对照小鼠心肌中差异的miRNAs。通过实时荧光定量PCR（RT-qPCR）检测miR-208b-3p 在血管紧张素Ⅱ（Ang Ⅱ）和高糖/葡萄糖氧化酶（G/Go）处理的C57BL/6乳小鼠心肌细胞（NMVCs）和心肌成纤维细胞（mCFs）中的表达；利用CCK8细胞增殖实验、流式细胞术和纤维化相关蛋白（包括COL1A1、COL3A1和α-SMA）表达检测来了解miR-208b-3p对mCFs纤维化表型的影响；双萤光素酶报告基因实验检测miR-208b-3p与潜在靶基因Mtf2和Pgrmc1 3'端非翻译区（3'-UTR）的结合作用；利用RT-qPCR和Western blot 法分别检测miR-208b-3p转染的 mCFs中Mtf2 和Pgrmc1 表达；通过小干扰RNA（siRNA）抑制Mtf2和Pgrmc1表达，并检测对mCFs中纤维化相关蛋白表达的作用。结果miRNA 表达谱和RT-qPCR结果证实miR-208b-3p在糖尿病db/db小鼠心肌中表达显著升高。miR-208b-3p前体与宿主基因Myh7在db/db小鼠心肌中表达显著升高，miR-208b-3p与Myh7 mRNA在乳小鼠来源的mCFs和NMVCs中均有表达，但在NMVCs中水平更高。miR-208b-3p在Ang Ⅱ和G/Go处理后的mCFs和NMVCs中表达均明显升高。miR-208b-3p可显著增加mCFs中纤维化相关蛋白COL1A1、COL3A1和α-SMA表达，但不影响mCFs的增殖能力和细胞周期分布特征。双萤光素酶报告基因实验显示miR-208b-3p与Mtf2和Pgrmc1 3'-UTR有结合作用。miR-208b-3p可在转录后水平抑制mCFs中Mtf2和Pgrmc1表达。miR-208b-3p、Mtf2 siRNA和Pgrmc1 siRNA均能一致性地促进mCFs中纤维化相关蛋白表达。结论miR-208b-3p通过靶向Mtf2和Pgrmc1基因发挥促进mCFs中纤维化相关基因表达的作用。

Objective To investigate the risk factors of cardiac arrest and to establish the logistic regression model. Methods Totally 238 patients with mechanical ventilation in a tertiary hospital were selected from September, 2019 to January, 2020. Multiple indicators of cardiac arrest group (n=72) and non-cardiac arrest group (n=166) were compared. Logistic regression was used to establish a risk prediction model, and the model power and its accuracy were evaluated by receiver operating characteristic. Results The study finally included arrhythmia, hypoxemia, acid-base imbalance, septic shock, history of cardiac arrest, multiple organ dysfunction syndrome to construct the risk prediction model. This model’s area under curve of receiver operating characteristic was 0. 909. When the best predicted probability was 0. 343, the sensitivity and specificity of the logistic model were 0. 819 and 0. 855, respectively. Conclusion The risk prediction model has satisfactory prediction effects and can be used to predict the risk of cardiac arrest in patients with mechanical ventilation, providing the reference for management and preventative treatment for high-risk cardiac arrest patients. (目的 探讨影响心脏骤停风险的因素, 并建立Logistic回归预测模型。方法 选取2019年9月—2020年1月医院收治的行机械通气的238例患者作为研究对象, 将心脏骤停组(n=72)和非心脏骤停组(n=166)的各项因素进行对比, 通过Logistic回归分析建立风险预测模型, 并通过ROC曲线检验模型的预测效果。结果 本研究共纳入心律失常、低氧血症、酸碱失衡、感染性休克、心脏骤停病史、多器官功能障碍综合症6个影响因素构建风险预测模型。本研究的ROC下面积为0. 909, 当最佳界值为0. 343时, 灵敏度为0. 819, 特异度为0. 855。结论 本模型预测效果良好, 适用于临床实践, 在机械通气患者中应用此模型可为临床医护人员及时采取预防性管理措施提供参考。)

Copyright of Chinese Journal of Pathophysiology is the property of Jinan University, School of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Yellow River is the property of Editorial Board of Yellow River and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The European Union (EU) is an important target market for the export of the plant-derived agro-products of China, and it is also one of the regions with the strictest food safety control. In recent years, EU has withdrawn the approval of a variety of pesticides, and lowered the maximum residue limits (MRLs) of related pesticides to the limit of quantification (LOQ), which had a significant impact on international trade of agro-products. The members of the World Trade Organization (WTO) pay more attention on the pesticide residue measures that EU has taken. In this article, the cases of the specific trade concerns on sanitary and phytosanitary measures (SPS STCs) related to the EU pesticide residue control that proposed by WTO members from 1995 to 2022 were analyzed and studied. The basic situation of the WTO member concerns about the measures that EU has taken on pesticides residue limits were systematically analyzed, including the total number of STCs, the members who raised the STCs, the specific measures that have been taken, the types of agro-products that are concerned, as well as the status of the STCs. The main countermeasures to overcome the negative impacts of the EU’s strict measures of the pesticide residue limits on international trade were elaborated and proposed. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Geology & Exploration is the property of Geology & Exploration Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Pearl River is the property of Pearl River Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Pearl River is the property of Pearl River Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Pearl River is the property of Pearl River Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Silk is the property of Zhejiang Sci-Tech University Magazines and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Oncology is the property of Editorial Board of China Oncology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Studies have shown that the bony anatomy of the radius and ulna plays a role in the stability of the distal radioulnar joint, especially the shape of the distal radius sigmoid notch. Previous studies have mostly focused on cadaver studies or biomechanical studies, while few studies have used imaging methods to assess the effect of morphology on the stability of the distal radioulnar joint. OBJECTIVE: To assess the effect of different shapes of sigmoid notch of distal radius on the stability of distal radioulnar joint by CT. METHODS: The CT images of wrist and forearm of 151 cases were analyzed retrospectively. According to the morphological characteristics of the sigmoid notch of the distal radius on the axial CT image, it was divided into four shapes “Flat”, “Ski”, “C” and “S”. The chi-square test was used to compare the differences between the 4-type notch. According to the clinical diagnosis of distal radioulnar joint instability, they were divided into instability group and stability group to compare the effects of different forms of radial sigmoid notch on the stability of distal radioulnar joint. RESULTS AND CONCLUSION: (1) There were 151 patients with wrist injury, including 77 males and 74 females, with an average age of 39.0 (55.0-32.0) years. There were 42 cases of Flat type radial sigmoid notch (27.8%), 47 cases of Ski type radial sigmoid notch (31.1%), 39 cases of C type radial sigmoid notch (25.8%), and 23 cases of S type radial sigmoid notch (15.2%). (2) According to the clinical diagnosis, the patients were divided into distal radioulnar joint instability group and stability group. There were 85 cases (56.3%) in the instability group, including 27 cases of Flat type, 30 cases of Ski type, 11 cases of C type and 17 cases of S type. There were 66 cases (43.7%) in the stable group, including 15 cases of Flat type, 17 cases of Ski type, 28 cases of C type and 6 cases of S type. (3) The statistical results showed that there were significant differences in the stability of distal radioulnar joint with different shapes of sigmoid notch of distal radius (Pearson X² =17.583, P=0.001). The distal radioulnar joint instability rate of type C sigmoid notch was the lowest, and there was a statistical difference with the other three types. The instability rate of distal radioulnar joint in Flat, S and Ski type sigmoid notch was higher, and there was no significant difference among the three groups. (4) It is concluded that Ski type and Flat type sigmoid notches of the distal radius are the most common, while type C sigmoid notch of the distal radius is helpful to maintain the stability of distal radioulnar joint. [ABSTRACT FROM AUTHOR]

Copyright of Water Conservancy Science & Techonlogy & Economy is the property of Water Conservancy Science & Technology & Economy Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Wool Textile Journal is the property of National Wool Textile Science & Technology Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Rural Water & Hydropower is the property of China Rural Water & Hydropower Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The Lipschitz continuity of solution mapping to parametric vector primal and dual Ky Fan in equalities in normed linear space is studied.The concepts of parameter vector primal and dual Ky Fan inequality and its efficient solutions are proposed, and the pseudo-monotonicity and strong quasiconvexity（quasi-concavity） of vector functions are introduced.The Lipschitz continuity optimality conditions of the solution mapping to parametric vector primal and dual Ky Fan inequalities are obtained by using the analysis method, and give an example to illustrate. [ABSTRACT FROM AUTHOR]

Copyright of China Oncology is the property of Editorial Board of China Oncology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Atomic Energy Science & Technology is the property of Editorial Board of Atomic Energy Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Agricultural Science & Technology (1008-0864) is the property of Journal of Agricultural Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shaanxi University of Science & Technology is the property of Journal of Shaanxi University of Science & Technology Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Henan Agricultural Sciences is the property of Editorial Board of Journal of Henan Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao is the property of Chinese Journal of Applied Ecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Herein, the slope- scale dynamic changes in water cycle processes such as infiltration, evapotranspiration, thermal-moisture conditions in the active layer, and suprapermafrost groundwater in response to changes in the underlying surface conditions are analyzed based on the complete hydrometeorological observation network in the small Fenghuoshan watershed (FHS)- a typical permafrost basin- in the source region of the Yangtze River. The following four key results were obtained: ① The multi- year average of actual evapotranspiration (ET ) of the FHS during the growing season was 472. 1 ± 42. 9 mm, and the order of meteorological factors affecting the ET was as follows: net radiation (sensitivity coefficient SRn = 1. 22, correlation coefficient R = 0. 93) > air temperature ( STa = 0. 33, R = 0. 84) > relative humidity (SHR = 0. 32, R = 0. 46) > wind speed (SU = - 0. 25, R = - 0. 27). The ET was positively correlated with vegetation cover and altitude on the slope scale. ② The initial and stable infiltration rates increased with altitude on the slope scale. During the initial thawing, completely thawed, and initial freezing periods, the respective stable infiltration rates at various slope positions were as follows: top of slope (1. 07 mm / min, 0. 63 mm / min, 0. 88 mm / min) > middle of slope (0. 29 mm / min, 0. 45 mm / min, 0. 21 mm / min) > base of slope (0. 11 mm / min, 0. 30 mm / min, 0. 10 mm / min), while the influence of vegetation coverage on the infiltration rate varied with the freezing-thawing period. ③ The differences in the freezing and thawing initiation times on the sunny and shady slopes, and at different slope positions, were reflected in the changes in soil moisture and groundwater level, thus explaining the spatial-temporal differences in the runoff- generation areas of the permafrost basin in going from the sunny slope to the shady slope, and from low altitude to high altitude. ④ The freezing-thawing regime of the active layer below 50 cm depth was found to significantly affect the groundwater dynamics, and the influence of topography, vegetation, and soil texture differences on heat transfer jointly led to the spatial variations in the suprapermafrost groundwater dynamics on the slope scale. [ABSTRACT FROM AUTHOR]

Copyright of Engineering Mechanics / Gongcheng Lixue is the property of Engineering Mechanics Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to overcome the problems of texture information loss, color offset distortion and reconstruction performance degradation in case of super resolution of images in low illumination environment, this paper proposed a super-resolution method of low illumination image based on color restoration and edge preservation. Based on anchored neighborhood regression (ANR), the method introduced the illuminance enhancement function of color restoration and edge preservation to improve the significance of image content and edge texture. Meanwhile, it selected the weighted least squares (WLS) as the central surround function to suppress the degradation of high-frequency features. Moreover, for the Y-channel component of YCbCr color space, it used the edge preserving illuminance enhancement function to calculate reflection component to further enhance the edge texture feature. The experimental results show that the proposed method achieves better visual effect. Compared with other methods, the PSNR of this method is improved by 63. 15%, SSIM is improved by 46. 86% and the perceived quality (PI) is improved by 4.12%. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Northwest A & F University - Natural Science Edition is the property of Editorial Department of Journal of Northwest A&F University (Natural Science Edition) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)