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Astrocytes are heavily activated in Alzheimer's disease, engulfing damaged synapses, Aß proteins, Tau proteins, apoptotic cells and other substrates. However, these substrates are difficult to degrade, accumulate as the disease progresses, and impair the phagocytosis of astrocytes. During phagocytosis, astrocytes recognize different substrates through a variety of phagocytosis receptors and partially degrade the substrates through degrading enzymes and lysosomal pathways. The accumulation of Aß and Tau proteins in astrocytes caused astrocyte immune and metabolic disorders, and Aẞ toxicity changed after phagocytosis. In addition, astrocytes and microglia form a complementary pattern and cooperate to complete phagocytosis through interaction. Regulating the pathway of astrocyte phagocytosis and degradation is believed to be a potential novo therapeutic for clinical treatment of Alzheimer's disease. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

【Objective】The cytochrome P450 family is an important enzyme system involved in glucosinolate synthesis in cruciferous plants, where in the CYP83 subfamily plays a predominant role in core structure formation, this work aims to investigate the Chinese cabbage (Brassica rapa ssp. Pekinensis) CYP83B1 gene functional role.【Method】RT-PCR was used to clone the CYP83B1 gene. Bioinformatics analysis software was utilized to predict the encoded protein's physicochemical properties, homology of the encoded protein, and promoter cis-acting elements. The expression pattern of BrCYP83B1 was analyzed by RT-qPCR, and a plant overexpression vector was constructed for further experimentation.【Result】The cDNA length of BrCYP83B1 was 1 500 bp, encoding a total of 499 amino acids. The protein belonged to cytochrome P450 superfamily and predominantly located in the cytoplasm. Its secondary structure primarily comprised of α-helixes and irregular coil. Homologous comparison illustrated that BrCYP83B1 had close relationship with Brassica napus L and Brassica oleracea L. var. italica. The BrCYP83B1 promoter contained cis-acting elements that were involved in the response to salicylic acid（SA), abscisic acid（ABA), and methyl jasmonate（MeJA), suggesting that the expression of BrCYP83B1 gene may be regulated by hormones. The expression of BrCYP83B1was detected in various plant organs, including the roots, stems, leaves, flowers and fruits from RT-qPCR results. Notably, the highest expression was observed in the leaves. Moreover, BrCYP83B1 significantly presented induction upon treatment with MeJA, while its expression was repressed by SA. Additionally, ABA treatment initially up-regulated and subsequently down-regulated the gene.【Conclusion】BrCYP83B1 may be involved in the response regulation of Chinese cabbage to hormones. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Ecology & Rural Environment is the property of Journal of Ecology & Rural Environment Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the effects of the Nrf2 activator CDDO-Im on hepatic steatosis in high-fat diet-induced obese mice. Methods: Thirty-three male C57BL/6J mice were randomly divided into two groups: one group of 16 mice was fed a normal diet, while the other group of 17 mice was fed a high-fat diet to establish an obesity model. After successful modeling, the mice were randomly divided into four groups: normal diet solvent control group (Control ND group), normal diet Nrf2 activator group (Nrf2(+) ND group), high-fat diet solvent control group (Control HFD group), and high-fat diet Nrf2 activator group (Nrf2 (+) HFD group). Nrf2 activator CDDO-Im and an equal volume of solvent were administered by gavage for 6 weeks, and the serum triglycerides (TG), total cholesterol (T-CHO), and low-density lipoprotein cholesterol (LDL-C) levels were measured in all groups. Hematoxylin-eosin (HE) staining was performed to observe the morphological changes in liver tissues. RT-qPCR was used to detect the mRNA expression levels of liver Nrf2 downstream antioxidant genes Ngol, Hol, and Gele, while Western Blot was used to assess the protein expression levels of NQO1, HO-1, and GCLC in the liver. Results: Compared with that in the normal mice, body weight, TG, LDL-C and hepatic steatosis in obese mice increased (P<0.05), while protein expression of GCLC decreased (P<0.05). In obese mice, compared with that in the solvent control group, body weight, serum TG levels and hepatic steatosis of mice in the Nrf2 activator group reduced (P<0.05), mRNA expression levels of Ngol and Gele increased (P<0.05), and protein expression levels of NQO1 and GCLC elevated (P<0.05). Conclusion: The Nrf2 activator CDDO-Im can ameliorate hepatic steatosis in high-fat diet-induced obese mice, and its mechanism may be through upregulating the expression of antioxidant genes, thus inhibits hepatic oxidative stress. [ABSTRACT FROM AUTHOR]

Objective: To analyze the technical key points of short ⁃ term high cervical spinal cord electrical stimulation in the treatment of severe consciousness disorders in patients with brain injury and clinical diagnostic and therapeutic value of this procedure. Methods: A retrospective analysis was conducted on 10 cases of short ⁃term high cervical spinal cord stimulation performed at the Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University from June to September 2023. The technical key points of the surgical process were analyzed, and the clinical application value was evaluated through follow⁃up analysis. Results: Under general anesthesia, with the patient in the prone position, a percutaneous puncture of the thoracic 8 intervertebral space was performed to access the extradural space, and under X⁃ray fluoroscopy, the top of the spinal cord stimulation electrode was successfully placed at the level of C2. Stimulation therapy was conducted for 2⁃3 week, with stimulation parameters selected as follows: frequency 5/ 70 Hz, voltage 1-5V, small stimulation cycle: on for 15 min, off for 15 min, large stimulation cycle: on at 08: 00 am, off at 20: 00 pm. Follow⁃up was conducted at 4 weeks post⁃surgery, with 1 out of 8 patients in a vegetative state（VS）reaching a minimally conscious state （MCS）+, 5 patients remaining MCS⁃, and 2 patients still in a VS status. Among the 2 patients who were MCS⁃ preoperatively, 1 patient recovered from a MCS, and 1 patient reached MCS+, with no surgery⁃related complications observed in either case. Conclusion: Short⁃ term high cervical spinal cord stimulation is minimally invasive, safe and effective, with short⁃term therapeutic and diagnostic value. It has broad prospects for application in the diagnosis and treatment of consciousness disorders. Attention should be paid to the specific difficulties and technical aspects of electrode placement during the surgical procedure. [ABSTRACT FROM AUTHOR]

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Zhejiang Electric Power is the property of Zhejiang Electric Power Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Materials Engineering / Cailiao Gongcheng is the property of Journal of Materials Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Materials Engineering / Cailiao Gongcheng is the property of Journal of Materials Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: There are still many problems to be solved or perfected in the treatment of ischemic heart disease by stem cell transplantation. Among them, the key of stem cell transplantation in the treatment of ischemic heart disease is that the transplanted cells can home to the damaged myocardium and survive there. OBJECTIVE: To evaluate the effect of tanshinone IIA on the survival and homing ability of myocardial precursor cells under hypoxia and investigate its related mechanism. METHODS: H9c2 cells were selected as the myocardial precursor cell model. The H9c2 cells were respectively intervened with cobalt chloride, tanshinone IIA+cobalt chloride and tanshinone IIA+cobalt chloride+AG126(ERK1/2 pathway inhibitor). Cell proliferation was detected with MTS method. Cell apoptosis was analyzed using flow cytometry. Cell migration was evaluated by scratch assay. The expression levels of ERK1/2 pathway related proteins (ERK1/2, p-ERK1/2, HIF- 1α, cleaved caspase-3, and MMP-9) were assessed using western blot assay. RESULTS AND CONCLUSION: (1) Compared with the cobalt chloride group, the proliferation of H9c2 cells treated with cobalt chloride combined with tanshinone IIA was accelerated; the apoptosis was reduced; and the homing ability was enhanced. During this process, the expression of ERK1/2 had no significant changes (P > 0.05), but the expression levels of p-ERK1/2, HIF-1α, and MMP-9 were significantly increased (P < 0.05), and the expression of cleaved caspase-3 was significantly decreased (P < 0.05). (2) Compared with the cobalt chloride + tanshinone IIA group, the ERK1/2 pathway in H9c2 cells treated with cobalt chloride + tanshinone IIA + AG126 was significantly inhibited, and the ability of cell survival and migration to the injured area was significantly decreased. (3) The results showed that tanshinone IIA could promote the survival and homing ability of myocardial precursor cells under hypoxia by regulating ERK1/2 pathway. [ABSTRACT FROM AUTHOR]

Copyright of Natural Gas Geoscience is the property of Natural Gas Geoscience and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shenyang Pharmaceutical University is the property of Shenyang Pharmaceutical University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Experimental Technology & Management is the property of Experimental Technology & Management Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Metal Working (1674-165X) is the property of Metal Working Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Dense mesh stent is the first choice for the treatment of giant aneurysms. However, due to the dense mesh and abnormal hemodynamic conditions after implantation, the risk of thromboembolism increases. Surface grafting of phosphorylcholine（PC） can improve the anticoagulant performance of implanted stents, but the preparation process of traditional biomolecular coupling method is complex. In this study, amino-rich coating（PDA/PAa） was constructed by grafting polyallylamine（PAa） on the surface of dopamine（PDA） coating through Schiff base reaction and Michael addition under alkaline condition. 2-methacryloyloxyethyl phosphorylcholine（MPC） was covalently fixed on the surface of the amino-rich coating by Michael addition reaction. The PDA/PAa/MPC coating was successfully fabricated by X-ray photoelectron spectroscopy（XPS）. The results of platelet adhesion test and whole blood test showed that the PDA/PAa/MPC coating had good anticoagulant activity. Cell experiments showed that the PDA/PAa/MPC coating had good cytocompatibility and could inhibit the adhesion and proliferation of smooth muscle cells（A7r5）. [ABSTRACT FROM AUTHOR]

Objective: To investigate the role of Ca2+-activated small conductance SK3 potassium channels in Cu-Aβ complex-induced microglial activation and the downstream signaling pathway. Methods: The Cu-Aβ complex-induced release of tumor necrosis factor-α (TNF-α) and hydrogen peroxide (H2O2) in cell culture supernatants were detected using ELISA and the Amplex Red reagent. The levels of mRNA and protein of potassium channels as well as phosphorylation levels of related signaling molecules were detected by qPCR and Western blot. Results: (1) The experimental results of pretreatment with different ion channel blockers or potassium channel blockers of different subtypes showed that SK3 channels may mediate microglial activation caused by Cu-Aβ complex. (2) The results of qPCR and Western blot detection showed that Cu-Aβ complex could upregulate SK3 mRNA and protein expression in microglia. (3) The application of SK3-siRNA to knock down SK3 expression showed that the downregulation of SK3 expression significantly inhibited microglial activation caused by Cu-Aβ complex. (4) The experimental results of Western blot detection showed that PI3K/Akt signaling and ERK signaling were involved in microglial activation caused by Cu-Aβ complex. (5) The results of experiments using specific blockers of signaling molecules further showed that SK3 channels may lie upstream of the PI3K/Akt-ERK signaling pathway during the microglial activation induced by the Cu-Aβ complex. Conclusions: SK3 channels mediate microglial inflammatory responses induced by Cu-Aβ complex through the downstream PI3K/Akt-ERK signaling pathway [ABSTRACT FROM AUTHOR]

Copyright of Journal of Engineering for Thermal Energy & Power / Reneng Dongli Gongcheng is the property of Journal of Engineering for Thermal Energy & Power and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Fudan University Journal of Medical Sciences is the property of Fudan University Journal of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Tsinghua Journal of Education is the property of Tsinghua University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

With the rapid development of China's urbanization, a large number of new urban spaces such as university towns have emerged. At the same time, the geographical "separation" between university towns and urban centers established on the fringe of the city has gradually emerged. This article uses "islandization" to summarize this phenomenon, and from the perspective of teacher behavior, take Jinan Changqing University Town as an example to explore. Mainly use questionnaire survey method and interview method to analyze the daily behavior characteristics of teachers' commuting, shopping, medical treatment, leisure, etc., and reveal the influencing factors and formation mechanism of the "islandization" of university towns. The study found that the incomplete living service facilities in university towns have made most teachers choose to live in the downtown area. The separation of work and residence has caused teachers to commute with high frequency and time. The life needs of teachers are not fully satisfied in the university city, so daily activities such as shopping, medical treatment, and leisure tend to be carried out in the downtown area. Therefore, it can be seen from the behavior of teachers that there are three levels of space in the Changqing University Town, the center of Changqing District, and the center of Jinan, and the characteristics of islanding of the University Town are obvious. Moreover, islandization is formed under the interrelation and mutual influence of three factors: material, behavior and psychology. [ABSTRACT FROM AUTHOR]

Copyright of Natural Gas Industry is the property of Natural Gas Industry Journal Agency and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Electronic Components & Materials is the property of Electronic Components & Materials and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Lubrication Engineering (0254-0150) is the property of Editorial Office of LUBRICATION ENGINEERING and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Computer Engineering & Applications is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 观察急性脑梗死患者血清Klotho水平变化，并分析其与卒中后认知障碍（PSCI）的关系。方法 选 择急性脑梗死患者661例（观察组），卒中后3个月根据北京版蒙特利尔认知量表（MoCA）评分分为PSCI患者238例 （MoCA 评分<26分）、认知正常 423例（MoCA 评分≥26分），另选择同期体检健康者 100例作为对照组。采用 ELISA 法检测两组血清Klotho水平，将急性脑梗死患者根据血清Klotho水平的3个四分位截点分为4个四分位数区间，比 较其PSCI发病率。多因素Logistic回归分析急性脑梗死患者血清Klotho水平对其发生PSCI的影响，采用Pearson相 关分析法分析急性脑梗死患者血清Klotho水平与MoCA评分的关系，受试者工作特征（ROC）曲线评价血清Klotho水 平对急性脑梗死患者发生 PSCI 的预测效能。结果 观察组血清 Klotho 水平低于对照组，观察组 PSCI 患者血清 Klotho 水平低于认知正常患者（P 均<0. 05）。血清 Klotho 水平在 Q1、Q2、Q3和 Q4四分位数区间的急性脑梗死患者 PSCI 发病率分别为 81. 07%（137/169）、28. 99%（49/169）、17. 96%（30/167）、13. 10%（22/168），急性脑梗死患者的 PSCI发病率随着血清Klotho水平升高而降低（P<0. 01）。多因素Logistic回归分析结果显示，血清Klotho水平降低是 急性脑梗死患者发生 PSCI的独立危险因素（P均<0. 05）。急性脑梗死患者血清 Klotho水平与 MoCA评分呈正相关 关系（r=0. 438，P<0. 01）。血清 Klotho 预测急性脑梗死患者发生 PSCI 的曲线下面积为 0. 819（95% CI：0. 788～ 0. 847）；当血清Klotho预测PSCI的约登指数为0. 538时，对应的截断值为259. 98 ng/L，敏感度为71. 01%，特异度为 82. 76%。结论 急性脑梗死患者血清Klotho水平降低且发生PSCI者降低更明显，血清Klotho水平降低与急性脑梗 死患者发生PSCI有关，且对PSCI的发生具有一定预测价值。 [ABSTRACT FROM AUTHOR]

Copyright of Journal of Shanghai University / Shanghai Daxue Xuebao is the property of Journal of Shanghai University (Natural Sciences) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Dalian University of Technology / Dalian Ligong Daxue Xuebao is the property of Journal of Dalian University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Test & Measurement Technology is the property of Publishing Center of North University of China and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effect of Kunxian capsule combined with candesartan axetil on blood pressure, renal function, blood lipids and inflammatory factors in patients with chronic glomerulonephritis complicated with hypertension. Methods 101 patients with chronic glomerulonephritis who were admitted to our hospital from November 2017 to December 2019 were selected and randomly divided into observation group (51 cases) and control group (50 cases). The control group was treated with candesartan cilexetil on the basis of conventional treatment, and the observation group was treated with Kunxian capsule on the basis of the control group. The clinical efficacy and adverse reactions of the two groups were compared. Results The total effective rate of the observation group was significantly higher than that of the control group (P<0.05). After treatment, the blood pressure, renal function indexes (24 h Upro, BUN, Scr), blood lipid indexes (TG, TC, LDL-C), and inflammatory factors of the two groups (IL-6, hs-CRP) significantly decreased, and the observation group was significantly lower than the control group (P<0.05). After treatment, the blood lipid index HDL-C of the two groups increased significantly, and the blood lipid index HDL-C of the observation group was significantly higher than that of the control group (P<0.05). Conclusion Kunxian capsule combined with candesartan axetil can enhance the clinical efficacy, improve renal function, regulate blood lipids and reduce inflammation in patients with chronic glomerulonephritis complicated with hypertension. [ABSTRACT FROM AUTHOR]