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Leisure plays an important role in people's happiness; therefore, facilitating participation in leisure activities has become one of the pathways to improve urban residents' wellbeing and realize high-quality new urbanization. This study focuses on migrant workers' leisure behavior and quality of life. Based on the selfselection hypothesis and structural equation modeling analysis, this study explores the influence of both leisure environment and leisure attitude on leisure behavior. First, our analysis of the leisure environment revealed that leisure behaviors differed according to leisure environments. Residents of resource-rich communities had the longest leisure time, a medium leisure distance, and a positive leisure attitude. Communities with medium leisure resources had the shortest leisure time and closest leisure distance. Communities with scarce leisure resources had the longest leisure distance and the most negative leisure attitude. Second, by examing the match of leisure attitudes and leisure environments, we found that the average leisure time of matching groups was longer, and they generally spent their leisure time within 1 kilometer around the community. Furthermore, the leisure time of residents in communities with scarce leisure resources did not show significant differences. For the mismatching groups of leisure attitudes and environments, about 60% of the residents spent less than 2 hours on average per day, and the leisure distance did not show any significant difference. Third, the structural equation modeling analysis indicated that both attitude and environmental attributes can affect migrant workers' leisure behavior; they further interact with each other and jointly determine residents' leisure behavior. The temporal (leisure time) and spatial (leisure distance) dimensions of leisure behavior are influenced by different mechanisms. Leisure attitude has the most direct effect on leisure time, while the effects of leisure environment on leisure distance are complex. Socio-demographic attributes affect leisure environment, leisure attitude, and leisure behavior. Men and women do not differ in terms of leisure time, but women's leisure distance is greater than men's. Age has no significant effect on residents' leisure behavior, but younger persons enjoy more leisure. Monthly household income has a significantly negative effect on residents' leisure time and leisure distance, while it has a significantly positive effect on leisure environment. Persons with higher education pay more attention to their leisure life, and spend more time and travel to participate in more leisure activities. This study makes three contributions. First, in the context of leisure scenarios, it promotes the combination of self-selection effect and rational behavior theory, and fully considers the role played by attitude in the mechanism of environmental influence on behavior. Existing studies of transportation mostly follow functionalism in the pursuit of efficiency, and the scope and ability of residents' self-selection is limited. This study of leisure behavior empirically demonstrates the importance of leisure environment and leisure concepts cultivation. Second, the study of migrant workers' leisure provides inspiration for the construction of new urbanization. In China's rapid urbanization, migrant workers have made positive contributions to the development of cities at the sacrifice of their youth and health. The leisure self-selection effect can be used to improve residents' leisure participation and subjective well-being by enhancing the community's leisure environment. Third, the migrant worker group is diversifying. With the deepening of new urbanization, their daily lives are changing and they are making continual efforts to adapt to urban life, rather than remaining passive. [ABSTRACT FROM AUTHOR]

The article systematically summarizes the research achievements in the content and methods of rural tourism innovation at home and abroad from the perspectives of innovation influencing factors, innovation mechanisms, innovation modes, innovation paths, innovation evaluation models, as well as qualitative and quantitative methods such as field investigation, field testing, and numerical analysis. Prospects were made for the further improvement of the deconstruction and reconstruction of the influencing factors of rural tourism innovation, the innovation mode and improvement path of rural tourism, the comprehensive integration of mechanisms and research methods to assist in rural poverty reduction and rural community recovery. [ABSTRACT FROM AUTHOR]

目的　总结 1例酒精性肝硬化并发食管胃静脉曲张出血 (EVB) 伴早期食管癌的治疗方法。方法　回顾 性分析1例酒精性肝硬化并发 EVB 伴早期食管癌患者的临床资料，总结其治疗方案。结果　患者中年男性，因“黑 便 2 d，腹痛、呕血5 h”入院，既往有“酒精性肝硬化，食管静脉曲张 (重度) ，门脉高压性胃病”病史 2 年余，“食管中上 段黏膜病变，早癌可能”病史 2 年余，“胃底静脉曲张组织胶注射”手术史4月余，“内镜下食管曲张静脉套扎术”手术 史9 d，饮酒史 30 余年，平均每日饮酒量折合乙醇约 200 g。入院后行急诊内镜检查提示急性上消化道出血，未见明 显活动性出血，给予药物止血、输血、保肝及营养支持等治疗。首次入院3个月后患者返院复查，明确诊断为肝硬化 失代偿期、门静脉高压、EVB、早期食管癌，既往有 EVB 史，符合经颈静脉肝内门体静脉分流术 (TIPSS) 手术适应证， 有内镜黏膜下剥离术 (ESD) 手术指征。排除禁忌证，于首次入院 3个月后行 TIPSS，术后随访 2月余，首次入院 4个 月胃镜检查显示曲张静脉直径较前缩小。排除禁忌证，于首次入院 6 个月行食管静脉曲张内镜下预防性套扎术，套 扎后接着进行早期食管癌 ESD，手术顺利，术后随访 10 个月，病情稳定。结论　对于肝硬化并发EVB伴早期食管癌 的患者，在对黏膜病变处采取内镜治疗等手术操作前可先行 TIPSS，TIPSS 可同时改善食管和胃底静脉的曲张程度， 能减少内镜手术中及术后再出血风险。 [ABSTRACT FROM AUTHOR]

An e-commerce closed-loop supply chain game model under the subsidy policy was constructed based on different cooperation models of partial authorization, full delegation and two-way competition. The key factors for manufacturers to engage in product green innovation were explored and the impact of government subsidies and innovation cost factors on product green innovation and pricing decisions was analyzed. It was shown that manufacturers make green innovation only when government subsidies or cost savings from green innovation are large enough. Government subsidies and manufacturers’ willingness to make green innovation are the highest under the partial authorization model. In contrast, government subsidies are the lowest under the two-way competition model and manufacturers’ willingness to make green innovation is the lowest under the full delegation model. Green innovation under the subsidy policy can reduce the selling price, increase the recycling price, and significantly improve manufacturers’ profit. [ABSTRACT FROM AUTHOR]

To evaluate the application value of serum 25-hydroxyvitamin D [25 (OH)D], anti-Mullerian hormone (AMH) and inhibin B (INHB) in pregnancy outcome of in vitro fertilization-embryo transfer (IVR-ET) in patients with diminished ovarian reserve (DOR). 292 DOR patients who underwent IVR-ET assisted pregnancy in our hospital from August 2019 to October 2021 were selected, according to the pregnancy outcome after assisted pregnancy, they were divided into pregnancy group (n=158) and non-pregnancy group (n=134), the clinical data and the levels of serum 25(OH)D, AMH and INHB in the two groups were compared, the predictive value of serum 25 (OH)D, AMH and INHB in separate and combination detection for pregnancy failure was evaluated by the receiver operating characteristic (ROC) curve. The influencing factors of pregnancy failure were analyzed by single factor analysis and multiple logistic regression. The levels of serum 25 (OH)D, AMH and INHB in pregnant group were significantly higher than those in non-pregnancy group (P<0.05). ROC curve analysis result showed that the area under the curve (AUC) of serum 25(OH)D, AMH, INHB and their combined detection in predicting IVR-ET pregnancy failure in patients with DOR were 0.714 (0.631~0.802), 0.801 (0.731~0.852), 0.634 (0.578~0.741), 0.853 (0.806~0.913) respectively, the AUC of the combined detection in predicting IVR-ET pregnancy failure in patients with DOR was higher than those in the separate detection. Single factor analysis results showed that the number of sinus follicles<5, the number of retrieved eggs<8, follicle stimulating hormone (FSH) / luteinizing hormone (LH)≥ 1.8, serum 25 (OH)≤ 25.05 μg/L, serum AMH≤ 1.08 ng/mL, serum INHB≤ 84.28 pg/ml in the non-pregnancy group were significantly higher than those in pregnancy group (P<0.05). Multiple logistic regression analysis results showed that FSH/LH≥1.8, serum 25(OH)D≤ 25.05 μg/L, serum AMH≤ 1.08 ng/mL, serum INHB≤ 84.28 pg/mL were the risk factors of IVR-ET pregnancy failurein patients with DOR (P<0.05). The low levels of serum 25(OH)D, AMH and INHB are related to IVR-ET pregnancy failure in patients with DOR, and the combined detection of the above index levels has high auxiliary predictive value for IVR-ET pregnancy failure. [ABSTRACT FROM AUTHOR]

Objective: To study the relationship between serum leptin, irisin, sex hormone binding globulin (SHBG) and aquaporin 8 (AQP8) and sex hormone levels and pregnancy outcome in patients with polycystic ovary syndrome (PCOS) infertility undergoing in vitro fertilization-embryo transfer (IVF-ET). A total of 293 patients with PCOS infertility undergoing IVF-ET who were admitted to our Hospital from January 2020 to January 2022 were selected, and the patients were divided into clinical pregnancy failure group (n=118) and clinical pregnancy success group (n=175) according to whether or not the pregnancy was clinically successful. Clinical data of patients were collected, and serum leptin, irisin, SHBG and AQP8 levels were measured. Pearson's correlation coefficient was used to analyze the correlation between serum leptin, irisin, SHBG and AQP8 levels and sex hormone levels in PCOS infertility, multivariate Logistic regression was used to analyze influencing factors of pregnancy outcome in PCOS infertility patients undergoing IVF-ET, and receiver operating characteristic (ROC) curves were used to analyze the value of serum leptin, irisin, SHBG and AQP8 levels alone and in combination to predict clinical pregnancy failure in PCOS infertility patients undergoing IVF-ET. Compared to the clinical pregnancy success group, the clinical pregnancy failure group had lower follicle stimulating hormone (FSH), gonadotropin (Gn) dosage, number of eggs gained, fertilization rate, excellent embryo rate and SHBG levels, and higher luteinizing hormone (LH), LH/FSH, testosterone (T), insulin resistance index (HOMA-IR), leptin, irisin and AQP8 levels. Pearson correlation coefficients showed that serum leptin, irisin and AQP8 were negatively correlated with FSH level, and positively correlated with LH, LH/FSH and T levels in patients with PCOS infertility (all P＜0.05). SHBG was positively correlated with FSH level, and negatively correlated with LH, LH/FSHand T levels (all P＜0.05). Multivariate Logistic regression analysis showed that LH/FSH, T, HOMA-IR, leptin, irisin and AQP8 were independent risk factors for clinical pregnancy failure in patients undergoing IVF-ET for PCOS infertility, and excellent embryo rate and SHBG were independent protective factors (all P＜0.05). The ROC curves showed that the area under the curve (AUC) for serum leptin, irisin, SHBG and AQP8 levels in combination to predict clinical pregnancy failure in PCOS infertility patients undergoing IVF-ET were greater than each indicator alone. Serum leptin, irisin, SHBG and AQP8 levels are associated with FSH, LH, LH/FSH, T levels and clinical pregnancy failure in PCOS infertility patients undergoing IVF-ET, and it is helpful to predict the pregnancy outcome of patients with PCOS infertility. [ABSTRACT FROM AUTHOR]

In order to improve the stability of power system operation, in view of the problem that the line power and node voltage will exceed the limit due to the influence of uncertain factors during the operation of the power grid, considering the two uncertain factors of wind power and load fluctuation, a risk value index of over-limit risk is proposed to identify the vulnerability of the power grid. link. First, define the risk value index of line power over-limit and node voltage over-limit risk value respectively; then, use the n-k method to simulate the situation of line disconnection and node failure in the power grid respectively, and obtain the line over-limit risk value and node over-limit risk Lines and nodes are sorted by value; and the binary decision diagram (BDD) algorithm is used to improve the identification efficiency of the n-k method; then experiments are carried out on the IEEE 30-node system and the IEEE 118-node system to verify the out-of-limit risk value index and the n-k identification method effectiveness and universality; Finally, the line disconnection and node fault are simulated respectively, and the identification indicators and methods are evaluated based on the load shedding of the IEEE 118-node system. [ABSTRACT FROM AUTHOR]

To explore the influencing factors and mechanism of people’s trust on autonomous vehicles(AVs), the trust model of AVs was designed from six perspectives: information content, information carrier, information channel, system transparency, technical capability and situation management. The structure validity, convergent validity and discriminant validity of confirmatory factor analysis, the intermediary effect analysis and path analysis were used for the fitting test of the structural equation model. It was found that information channel, system transparency and information carrier have significant effect on AVs trust. Information content, information carrier and information channels not only affect AVs trust directly, but also affect AVs trust through the intermediary variable of system transparency. [ABSTRACT FROM AUTHOR]

The lithium-rich cathode material xLi2MnO3· (1-x) LiMO2 (M=Ni, Co, Mn, etc., 0< x< 1) has the huge advantages of high capacity (up to 300 mA·h/g or more) and low cost, and is known as probably the most important next-generation cathode material for lithium-ion batteries. It has received great attention and extensive research from various countries. At present, this material still has problems such as low initial (first cycle) Coulomb efficiency, poor cycle performance, and serious voltage attenuation, which all seriously hinder the development and practical application of the material. In order to solve these problems of this material, especially its insufficient cycle stability and voltage attenuation, a lot of research work has been carried out on the degradation mechanism and stability improvement of the lithium-rich cathode material, and some important progresses have been made in recent years. This article introduces the structure and working principle of the lithium-rich cathode material, focusing on the research work in recent years on the degradation mechanism of the lithium-rich cathode material and improving the stability of the lithium-rich cathode material. The further research work has been prospected. [ABSTRACT FROM AUTHOR]

In the modular multilevel converter based multi-terminal DC (MMC-MTDC) system, the virtual synchronous generator (VSG) control cannot take into account the problem of DC voltage fluctuation regulation when maintaining the frequency stability of the AC grid. The U 2 -P DC voltage droop control was introduced into the VSG controller for the receiving-end converter in the MMC-MTDC system, and the VSG control with additional DC voltage was obtained. This control can not only realize the frequency adjustment in the AC region, but also control the DC voltage. By analyzing the influence of moment of inertia in VSG on the frequency response of AC grid, an adaptive virtual moment of inertia adjustment method based on fuzzy control was designed on the basis of additional DC voltage VSG control. By flexibly adjusting the virtual inertia, the converter shows smoother and faster dynamic response performance in the process of supporting frequency fluctuation. The effectiveness of the proposed strategy is verified on the MATLAB/ Simulink simulation platform, which shows that the proposed strategy can adjust the frequency and DC voltage at the same time and can show better frequency dynamic response performance. [ABSTRACT FROM AUTHOR]

Postpartum hemorrhage is still one of the main causes of maternal death. Some studies have confirmed that oxytocin administration during labor is associated with a higher risk of postpartum hemorrhage, especially when the dose used during labor is high, the duration of time is long, or the woman does not receive active management in the third stage of labor. The desensitization sequence in oxytocin receptors is one of the pathophysiologic hypotheses, and clinically this can manifest as a reduction in oxytocin-induced contractility, resulting in uterine atony and postpartum hemorrhage. This paper reviews the research progress of the association between oxytocin during labor and risk of postpartum hemorrhage, so as to contribute to the establishment of a reasonable oxytocin administration and decrease the incidence of postpartum hemorrhage secondary to uterine atony. [ABSTRACT FROM AUTHOR]

Objective: To investigate the factors of spontaneous recanalization (SR) and its impact on long-term prognosis in patients with acute ST -segment elevation myocardial infarction (STEMI). Methods: The study consecutively enrolled patients diagnosed with STEMI and underwent primary percutaneous coronary intervention in Nanjing First Hospital from July 2011 to April 2019. Patients were divided into the SR group (TIMI flow grade 0-1) and the non -SR group (TIMI flow grade 2-3) based on the results of coronary angiography. The data of the two groups were collected, including general clinical data, laboratory test results, coronary angiography and drug treatment. The primary endpoint was all - cause death. Results: Total 1 124 patients were enrolled, including 272 patients (24.2%) in the SR group and 852 patients (75.8%)in the non-SR group. Patients with SR were significantly decreased in proportions of hypertension, creatine kinase isoenzyme -MB (CK -MB) peak value, creatinine levels, uric acid levels, thrombus vessel aspiration rate, intra-aortic balloon pump (IABP) implantation rate and in-hospital mortality, compared with the non-SR group. However, the left ventricular ejection fraction was higher in the SR group than in the non-SR group. Multivariate logistic regression analysis showed that hypertension was a disadvantage for SR (OR=0.744, 95%CI: 0.561-0.985, P=0.039). The follow-up period was 79 (61, 101) months, during which 124 patients occurred all - cause mortality. Kaplan - Meier curves indicated that there was no significant difference in survival time between the SR group and the non-SR group (log-rank P=0.182). Multivariate COX regression analysis revealed that age, Killip classification, creatinine, in-hospital IABP implantation, left ventricular ejection fraction, single-vessel disease, ticagrelor and β -blocker were independent predictors of all - cause death in STEMI patients. Conclusion: Nearly 1/4 of STEMI patients occur SR before the primary percutaneous coronary intervention. Hypertension is an unfavorable factor for SR occurrence. However, long -term follow-up reveals that SR does not reduce all-cause mortality in STEMI patients. [ABSTRACT FROM AUTHOR]

The growth and decline of yin and yang, and the conflict between healthy qi and pathogenic factor are important theoretical foundations for traditional Chinese medicine (TCM) to interpret disease occurrence and development, which is of significance for guiding the understanding of "inflammation to cancer" of chronic gastritis and its prevention and treatment. From the perspective of Western medicine, the imbalance of the immune system is the root cause of tumors, and immunotherapy is hailed as the most promising means for curing cancer. The theories of yin and yang, and healthy qi and pathogenic factor of TCM have much in common with the understanding of immunity in western medicine. Especially in recent years, the idea that tumor immunotherapy should return from " immune enhancement '' to " immune normalization" is similar to the core idea of " harmonizing yin and yang, reinforcing healthy qi to dispel pathogenic qi" in TCM. Based on the combination of theories from both traditional Chinese medicine and Western medicine, this paper aims to promote the theoretical integration and development of traditional Chinese medicine and Western medicine in prevention and treatment of inflammation to cancer" of chronic gastritis. [ABSTRACT FROM AUTHOR]

目的探讨健康行为管理对功能性便秘(FC)患者生活质量及便秘症状的影响。方法选取2017年4-7月在本院门诊就诊的153例FC患者为研究对象,并随机分成对照组(76例)和干预组(77例)。对照组采用常规健康教育和护理方法,干预组在对照组基础上联合健康行为管理,比较两组便秘症状及生活质量改善情况。结果干预组生活质量评分、便秘症状评分明显优于对照组,差异均有统计学意义(P<0.05)。结论健康行为管理能有效改善FC患者症状,提高其生活质量,值得在临床上推广应用。 [ABSTRACT FROM AUTHOR]

In order to improve the efficiency of the purchasing system, the relationship between centralized governmental purchasing price and its determinants was analyzed. Seven hundred and eighty three cases of desktop computer purchasing projects at an affiliated hospital of a university were included in the study, multiple linear regression analysis was performed, purchasing prices of the computers were used as dependent variables, and factors including purchasing method, basic parameters of the computer, year of purchasing, suppliers and manufacturers were used as independent variables. Purchasing method was found to be the most significant influencing factor for purchasing price and purchasing performance. CPU type and disk capacity had the second importance. Year of purchasing, installation of the Windows system and memory capacity sequentially came as the least influential factors. The types of suppliers, manufacturers and video cards had no statistical significance. It was indicated that mass centralized governmental purchasing method was an effective approach to reduce purchasing price of desktop computers, and it helped to eliminate brand monopoly and promote the incorrupt governmental policy of "fairness, justice and transparency" during the centralized purchasing process in colleges and universities. [ABSTRACT FROM AUTHOR]

Objective To observe the effect of curcumin on DNA methyltransferase (Dnmts) activity and tumor suppressor gene human H-cadherin (CDH13) in non-small-eell lung cancer i NSCLC A549 cells and to explore the mechanism of curcumin s demethylation. Methods A549 cells were divided into two groups: the observation group and the control group. Cells in the observation group were cultured with 40 μmol/ L curcumin and the culture medium, while cells in the control group only with the culture medium. MTT assay was used to detect the cell proliferation, and RT-PCR was used to detect the expression of CDH13 mRNA. CpG island methylation status of CDH13 promoter was detected by methylation-specific PCR (MSP) . and catalytic activity of Dnmts was detected by enzyme colorimetric determination kit. Results The OD of the observation group was 0. 638 ±0. 184. which was lower than that (0. 859 ±0. 040) of the control group (P < 0.05). The relative expression level of CDH13 mRNA in the observation group was 0.64 ±0.09. which was higher than that (0.43 ±0. 12) of the control group. There were methylation amplification bands, but no demethylation bands in the control group, and there were both methylation amplification bands and demethylation bands in the observation gmup. In the observation group and the control group, the activities of Dnmtl were separately (0. 153 ±0.016) and (0. 770 ± 0.014) μmol/min, and the activities of Dnmt3b were (0. 137 ±0.020) and (0. 179 ±0.013) μmol/min, respectively. The activities of Dnmtl and Dnmt3b in the observation group were lower than those in the control group (all P < 0. 05). Conclusion Curcumin inhibits the methylation status of CDH13 by decreasing the activity of Dnmts. and thereby inhibits A549 cell proliferation. [ABSTRACT FROM AUTHOR]

Objective To investigate the relationship between serum complement- C1q/TNF related protein 1 (CTRP1), CTRP5 and ratio of CTRP1 to CTRP5 (CTRP1/CTRP5) and unstable angina pectoris (UAP). Methods A total of 103 patients with UAP were selected as subjects. Patients were divided into the mild coronary stenosis group (GS≤39, n=53) and the severe coronary stenosis group (GS＞39, n=50) according to the median of Gensini (GS) score. Patients were divided into the single-vessel lesion group (n=20), the double-vessel lesion group (n=46) and the multi-vessel lesion group (n=37), according to the number of coronary artery lesions. Forty-seven patients with cardiac neurosis whose coronary stenosis was less than 50% were selected as the control group. Enzyme linked immunosorbent assay was used to detect serum levels of CTRP1 and CTRP5, and then the level of CTRP1/CTRP5 was calculated. Results The levels of CTRP1, CTRP5 and CTRP1/CTRP5 were higher in the UAP group than those in the control group (P＜0.05). The levels of CTRP1 and CTRP5 were higher in the severe coronary stenosis group than those of the mild coronary stenosis group (P＜0.05). The level of CTRP1 was higher in the multi-vessel lesion group than that in the single-vessel lesion group among UAP with different vascular lesions (P＜0.05). Results of multivariate Logistic analysis showed that CTRP1 was an independent predictor of UAP. ROC curve analysis showed that the area under the ROC curve (AUC) of serum CTRP1, CTRP5 and CTRP1/CTRP5 for UAP assisted screening were 0.757, 0.631 and 0.625, and the cut-off values were 870.33 µg/L, 43.04 µg/L and 18.41, respectively. The sensitivity of CTRP1/CTRP5 was higher (84.5%), and the specificity of CTRP1 was higher (78.7%). Conclusion CTRP1 and CTRP5 are involved in the occurrence and development of UAP. Detection of serum levels of CTRP1 and CTRP5 and calculation of CTRP1/CTRP5 levels are helpful for UAP screening and disease assessment. [ABSTRACT FROM AUTHOR]

Formyldeoxycholic acid modified Fe3O4 nanoparticles (FDCA-MNPs)have been successfully constructed. The structure, morphology and magnetic properties of FDCA-MNPs are characterized by Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM)and vibrating sample magnetometer. Oxytetracycline (OTC) is used as a model drug to evaluate the drug loading and release behaviors of FDCA-MNPs. The maximum loading of OTC is 59. 7 mg/g, and the loading behavior follows Freundlich adsorption balance equations with multilayer adsorption．Furthermore, FDCA-MNPs@OTC shows a higher release rate at pH=9 (11. 8%)than that of pH=7 (8. 8%). The bacteriostatic activities of FDCA-MNPs, OTC, FDCA-MNPs@OTC against E. coli are compared in vitro. The results show that FDCA-MNPs have no inhibition-activity for E. coli, meanwhile, FDCA-MNPs@OTC displays better sterilization ability than OTC at the same concentration. The minimum antibacterial concentration is 3 μg/mL, and the antibacterial rate reaches 97. 8%. It is proved that the synergistic effect of drug carrier and drugs reveals good antibacterial properties and reduce the dosage of antibiotics. [ABSTRACT FROM AUTHOR]

The symmetrical and asymmetrical rolling process was used to produce Cu/Al composite strip. Interfacial reaction during annealing and strengthening mechanism after asymmetrical rolling were investigated. The interfacial microstructure and fracture morphology of tensile test were obtained by scanning electrical microscope. The distribution of interfacial elements was analyzed by line scanning and electron microprobe analysis. The interfacial phases were analyzed by XRD. The peeling and tensile tests were carried out to study mechanical properties of the composite strips. The results indicate that the diffusion layer with three sublayers forms after annealed at 400 °C for 1 h. There is a sudden change of element content in each sublayer. A large amount of copper and the CuAl2, Cu9Al4, CuAl and Cu4 Al phases are detected on the Al peeled surface, while only the Cu9Al4 and Cu4Al phases are detected on the Cu peeled one. Therefore, the asymmetrical rolling bonding can improve the interfacial strength and tensile property of the composite strip and reduce the damage of interfacial interlayer from the failure. [ABSTRACT FROM AUTHOR]

The experiment was to study the effect of enzymatic hydrolysis of soybean meal in bait on growth and intestinal health of Procambarus clarkii. A total of 300 healthy (26.30±3.19) g Procambarus clarkii were randomly divided into four groups, with three replicates in each group and 25 Procambarus clarkii in each replicate. Procambarus clarkii in experimental group A (control group) were fed with basal diet, experimental group B, group C and group D were fed with 36%, 40% and 44% enzymatic hydrolysis soybean meal instead of soybean meal and fish meal in basal diet. The experiment lasted for 6 w. The results showed that the weight gain rate and specific growth rate of Procambarus clarkii in group B and group C were significantly higher than those in control group (P<0.05). The feed coefficient of Procambarus clarkii in group B and group C was significantly lower than that in control group (P<0.05). Firmicutes and Tenericutes in group B and group C were significantly higher than those in other groups, while Proteobacteria and Vibrionaceae were obviously lower than those in other groups. The experiment indicates that the appropriate proportion of enzymolysis soybean meal in diets was 36% to 40%. Too high supplemental level can reduce the growth performance of Procambarus clarkii, change the structure of intestinal flora, which is not conducive to the cultivation of Procambarus clarkii. [ABSTRACT FROM AUTHOR]

BACKGROUND: With the constant innovation and development of micro-pattern technology, it has also been applied widely in cell biology, tissue engineering and regenerative medicine, which provides new impetus for the construction of artificial tissues in vitro. OBJECTIVE: To summarize the classification, characteristics and application of micro-pattern technique in tissue engineering. METHODS: The authors performed a data retrieval of PubMed, Web of Science and CNKI to search the articles addressing micro-pattern technique and its application in tissue engineering published from 2001 to 2017, and reviewed the literatures systematically. The keywords were “micro-pattern technique, tissue engineering” in English and Chinese, respectively. RESULTS AND CONCLUSION: Using the micro-pattern technique, patterned cell alignment is formed to control the shape of stem cells, and regulate stem cell fusion and differentiation. Moreover, artificial tissue engineering products have been developed and used as tissue substitutes for bone tissue engineering, muscle tissue engineering, vascular tissue engineering, nerve tissue engineering and liver tissue engineering. However, cell biology mechanisms and internal mechanisms underlying the use of micro-pattern technique in the artificial tissue construction need to be further explored and elucidated. For example, future investigations are warranted on how to construct artificial muscle tissue using the micro-pattern technique, how to purify Schwann cells, as well as the development and innovation of micro-pattern technique in vascular and liver tissue engineering research. [ABSTRACT FROM AUTHOR]

糖原累积症（glycogen storage disease, GSD）是先天性酶缺陷所致糖原代谢异常相关的一 种常染色体隐性遗传病。本研究以浙江大学医学院附属儿童医院 2019 年 １月 １日至 2020 年 12 月 30 日收治的 ３例糖原累积症Ⅰα型合并泌尿系结石患儿为研究对象，对 ３例患儿的临床资料、辅助检查、 治疗经过进行回顾性分析。 [ABSTRACT FROM AUTHOR]

Objective: To study the relationship between circulating tumor cells （CTC） and serum scc-ag and keratin 19 soluble fragment（cy-fra21-1） levels in patients with non-small cell lung cancer （NSCLC）. Methods: 100 NSCLC patients admitted to our hospital from February 2017 to February 2019 were included in the study, which was referred to as NSCLC group. Another 100 patients with benign lung lesions admitted to our hospital at the same time were taken as the benign lesion group. Another 100 healthy volunteers who underwent physical examination in our hospital at the same time were selected as the control group. The CTC and serum scc-ag and cy-fra21-1 levels of the three groups were detected and compared, and the correlation between CTC and serum scc-ag and cy-fra21-1 levels was analyzed by Pearson correlation. The diagnostic efficacy of CTC and serum scc-ag and cy-fra21-1 levels in NSCLC was analyzed by ROC curve. In addition, the relationship between CTCS, serum scc-ag, cy-fra21-1 and lymph node metastasis in NSCLC patients was analyzed. Results: The levels of CTC, serum scc-ag and cy-fra21-1 in the NSCLC group and the benign lesion group were higher than those in the control group, and the levels of CTC, serum scc-ag and cy-fra21-1 in the NSCLC group were higher than those in the benign lesion group （all P<0.05）. Pearson correlation analysis showed that there was a positive correlation between CTC and serum scc-ag and cy-fra21-1 levels in NSCLC patients （r=0.642、0.601, P<0.05）. According to ROC curve analysis, the combined detection of CTC, serum scc-ag and cy-fra21-1 levels in the diagnosis of NSCLC showed that the area under the curve, the sensitivity and the specificity were all higher than those measured separately （all P<0.05）. The levels of CTC and serum scc-ag and cy-fra21-1 in patients with NSCLC lymph node metastasis were higher than those in patients without lymph node metastasis （all P<0.05）. Conclusion: There is a significant positive correlation between CTCS and serum scc-ag and cy-fra21-1 levels in NSCLC patients, and the combined detection of the three can improve the diagnostic value of NSCLC, and the above three indicators are closely related to lymph node metastasis. [ABSTRACT FROM AUTHOR]

Objective: To explore the correlation of serum hydrogen sulfide (H2S), growth differentiation factor-15 (GDF-15), Pentraxin-3 (PTX-3) levels with blood coagulation function, inflammation indexes and disease score in sepsis patients. Methods: 52 cases of sepsis patients admitted to our hospital from February 2018 to February 2020 were randomly selected as the sepsis group, and 46 cases of septic shock patients admitted to the same period were selected as the shock group, at the same time, 50 healthy people who had physical examination in our hospital were taken as control group. Serum H2S, GDF-15, PTX-3 levels, coagulation function and inflammation indexes were detected in the three groups of subjects. The coagulation function indexes include platelet count (PLT), activited partial thomboplastin time (APTT), prothrombin time (PT), and fibrinogen (FIB). Acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ), Quick sequential organ failure assessment (qSOFA) were used to score the patients in the sepsis group and shock group. The correlation of serum H2S, GDF-15, PTX-3 with patients' coagulation function, inflammation indexes and disease score were analyzed. Results: The serum H2S, PLT in the sepsis group and shock group were lower than that in the control group, and the shock group was lower than the sepsis group (P<0.05). Serum GDF-15, PTX-3, APTT, PT, FIB, PCT, CRP in the sepsis group and shock group were higher than those in the control group, and the shock group was higher than the sepsis group (P<0.05). The scores of APACHEⅡ and qSOFA in the sepsis group were significantly lower than those in the shock group (P<0.05). Serum H2S was positively correlated with PLT (P<0.05), and negatively correlated with APTT, PT, FIB, PCT, CRP, APACHE II score, qSOFA score (P<0.05). Serum GDF-15, PTX-3 were negatively correlated with PLT (P<0.05), and positively correlated with APTT, PT, FIB, PCT, CRP, APACHE II score, qSOFA score (P<0.05). Conclusions: Serum H2S in sepsis patients was significantly down-regulated, while serum GDF-15 and PTX-3 are increased. The three are closely related to coagulation function, inflammation and disease score, which may be an important reason for the progress of sepsis. [ABSTRACT FROM AUTHOR]

Objective To screen out the optimal conditions for extraction and purification of total flavonoids from the herb pair of Scutellariae barbatae and Hedyotis diffusa. Methods Single factor and L9 (34) orthogonal experiment was de signed with the extraction ratio and extract quantity of totfl flavonoids as indexes,using matching of herb pair,ethanol concentration, solid-liquid ratio, extraction time as inspected elements. The technical process for purification of total flavonoids with the static and dynamic adsorption experiments was screened by adsorption and desorption ratio as targets. Results The optimll process conditions were : ethanol concentration 70%，the matching of herb pair of 4 a 1，the solid-liquid ratio of 1 : 25，extraction for 3 times and 2h for each time. The parameters of the purification process were as follows : concentration of sample 63. 14 mg/ ml and pH value 4. 0, which used in the chromatographic column of polyamide resin at a flow velocity of 1. 5 ml/min. The chromatographic column was eluted with purified water of 3. lBV,and then eluted with 65% ethanol concentration of 9. 3BV at a flow velocity of 3ml/min. The purity of the total flavonoids was 40. 39% in the fine product, and the transfer rate was 8.. 57%. Conclusion The optimal process conditions were reasonable and feasibl.. The purification technique of polyamide resin was uncomplicated and had a good effect. [ABSTRACT FROM AUTHOR]

目的: 探讨血清脑钠肽(BNP)、肌钙蛋白I(TnI)及D-二聚体水平对急性肺栓塞患者病情及预后评估的价值。方法选取急性肺栓塞患者96例(观察组)，其中大面积肺栓塞12例、次大面积肺栓塞52例、非大面积肺栓塞32例；好转出院90例，死亡6例；另外选取体检健康者26例作为对照组。比较两组入院时外周静脉血血清BNP、TnI及D-二聚体水平。采用受试者工作特征(ROC)曲线分析血清BNP、TnI、D-二聚体单独及联合检测对急性肺栓塞患者预后的诊断价值。结果观察组血清BNP、TnI、D-二聚体水平均高于对照组(P均<0．05)，非大面积、次大面积、大面积肺栓塞患者血清BNP、TnI、D-二聚体水平逐渐升高(P均<0．05)，死亡患者血清BNP、TnI、D-二聚体水平均高于存活者(P均<0．05)。血清BNP、TnI、D-二聚体联合检测对急性肺栓塞患者预后评估的ROC曲线下面积为0．864、敏感性为0．825、特异性为0．835，均高于三项单独检测。结论急性肺栓塞患者血清BNP、TnI、D-二聚体水平升高，三者的水平变化可反映急性肺栓塞病情及预后，三者联合检测可提高对其预后的评估价值。 [ABSTRACT FROM AUTHOR]

For comprehensively understanding of the chemical composition in Xueshuan Xinmaining Tablet（XXT）, ultra high performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF MS) was developed. The automated data processing software UNIFI was selected to perform the screening analysis on the structural characteristics and MS fragmentation behavior, especially for characteristic fragments. Separation was performed on a Waters ACQUITY UPLC BEH C18 column (100 mm×2.1 mm×1.7 μm) at 40 °C. The mobile phase was consisted of 0.1% formic acid aqueous solution (A) and 0.1% formic acid in acetonitrile (B) with the flow rate of 0.4 mL/min. The data were collected with Masslynx V4.1 workstation. The MS raw data were processed using the streamlined workflow of UNIFI software to quickly identify the chemical components that met the match criteria with the in-house Traditional Medicine Library and the self-built database. The self-built database of compounds, such as saponins, flavonoids, volatile oil, amino acids and so on, was established by searching online databases such as China Journals of Full-Text Database (CNKI), PubMed, Medline, Web of Science and ChemSpider. By comparing the exact molecular mass, retention time, and mass spectrometry fragment ion information of each component, a total of 187 chemical constituents are identified, including triterpenoid saponins, phenanthrenes, oxadienes, steroids and other structural types of compound. This method is rapid and comprehensive for analysis of the chemical constituents of complicated herbal extracts. XXT is rich in small chemical components with various structural types. The study offers the pharmacodynamic basis for antithrombus effect and multi-target mechanism of XXT. [ABSTRACT FROM AUTHOR]

For the embedded professionals training in Chinese universities, the theory teaching is too much, practice teaching is too few. It lacks practice environment and platform support in practice teaching, and students learning process lacks interest, and enthusiasm is not high. Combined with excellent engineers training and discipline competition platform, we carry out teaching reform through the construction of embedded direction of the theory and practice of curriculum system. The establishment of innovative embedded talent training platform is based on “ Learning and Competition” platform. We hope our experience can play a reference role in the cultivation of innovative talents in the universities. [ABSTRACT FROM AUTHOR]

Experimental teaching reform is a complex system engineering. Tis paper analyzes problems and the reasons in the current teaching course of "digital system design". The required teaching content, teaching methods and the key means for the course of experimental teaching are presented. New ideas are put forward on practice teaching reform, and the form of microlecture teaching is introduced into practice. The results show that the reform measures can stimulate students' interest in learning, promote student mastery of theoretical knowledge and understanding, and improve practice and innovative ability of students, provide a useful reference for the future teaching practice. [ABSTRACT FROM AUTHOR]

目的：了解天津市居民丙型肝炎（丙肝）患病率和丙型肝炎病毒（HCV）感染情况，为丙肝的防治提供依据。方法①丙肝患病率调查：采用整群抽样方法随机抽取547782名区县所辖的街／乡和本市户籍居民，根据丙肝诊断标准（WS 213-2008）确诊丙肝。分析不同年龄、不同性别及不同地区丙肝患病率。②HCV感染情况调查：采取整体分层随机抽样的方法，从547782名调查对象中抽取1～59岁者2181名，采用ELISA法检测抗-HCV，分析不同年龄、不同性别及不同地区丙肝患病率。结果①丙肝患病率：天津市居民丙肝患病率为24．10／10万（132／547782），丙肝患病率随年龄增加而增高（χ2＝14．85，P＜0．05），远高于历年最高报告值。男性、女性居民丙肝患病率分别为33．04／10万、15．25／10万，P＜0．05；市内六区患病率最高，为42．97／10万，与其他地区比较P＜0．05。②抗-HCV阳性率：本次调查为0．64％（14／2181），远低于1992年的1．7％，男性与女性差异无统计学意义；50～59岁人群抗-HCV阳性率明显高于其他各年龄者，P均＜0．05。结论天津市居民抗-HCV感染率较1992年明显下降，但是丙肝患病率远高于历年最高报告值。 [ABSTRACT FROM AUTHOR]