Search

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Osteoporosis (OP) is one of the main problems affecting the health of middle-aged and elderly people, and its most serious complication is osteoporotic fracture (OPF), which also has a high disability and mortality rate. The accurate screening and diagnosis of OP mainly rely on imaging analysis, and the diagnosis result rely on the subjective judgment of doctors. Therefore, the traditional imaging method of OP have certain challenges to the accurate screening, diagnosis and differentiation of OP. The cross-fusion of machine learning (ML) and imaging images effectively improves the diagnostic efficiency of clinicians, while realizing the prediction of unknown diseases (such as OPF). Recently, significant progress has been made in the screening and diagnosis of OP and in the diagnosis and prediction of OPF. This paper will review the recent related studies on ML model-assisted screening and diagnosis of OP based on imaging data, so as to provide new ideas for accurate clinical diagnosis and treatment of OP. [ABSTRACT FROM AUTHOR]

Osteoporosis (OP) is a kind of bone disease related to aging. Its onset is obscure and development is gradual. Patients are without obvious clinical manifestations in the early stage. However, with the progress of the disease, bone loss and bone tissue microstructure destruction occur, and bone pain, spine deformation, and even osteoporotic fracture (OPF) and other serious complications may develop. Dual-energy X-ray absorption method is the current gold standard for clinical diagnosis of OP. Because its diagnostic accuracy is affected by the factors of body weight, lumbar degenerative changes, and aortic wall calcification, a false negative diagnosis is possible. In recent years, artificial intelligence (AI) has developed rapidly in the medical field. At present, AI has been widely used in the research of OP. Its research in the field of OP screening, diagnosis, and prediction has become a new hot spot. This paper expounds the application status and advantages of AI in OP diagnosis and treatment from four aspects, i.e., OP early screening, medical imaging performance, clinical diagnosis and treatment data, and OPF risk prediction, so as to provide a new direction for the accurate diagnosis and treatment of OP. [ABSTRACT FROM AUTHOR]

BACKGROUND: At present, although there are many clinical methods for the treatment of knee osteoarthritis, unfortunately, the clinical benefits of traditional treatment methods are limited. In recent years, there are many studies on intra-articular injection of autologous bone marrow aspiration concentrate in the treatment of knee osteoarthritis. OBJECTIVE: To review effect and mechanism of autologous bone marrow aspiration concentrate in the treatment of knee osteoarthritis. METHODS: Using “bone marrow aspiration concentrate, knee osteoarthritis, bone marrow mesenchymal stem cells, transforming growth factor β, platelet derived growth factor” as Chinese search terms, relevant articles were searched in the databases of CNKI, Wanfang, and VIP. Using “bone marrow aspirate concentrate, BMAC, knee osteoarthritis, KOA, bone marrow mesenchymal stem cells, BMSCs, transforming growth factor β, TGF-β, platelet derived growth factor, PDGF” as English search terms, relevant articles were searched in PubMed and Web of Science databases. The retrieval time was from database establishment to August 2021. According to the inclusion and exclusion criteria, 60 articles were finally included for review. RESULTS AND CONCLUSION: (1) Various components in the autologous bone marrow aspiration concentrate can play an important role in the treatment of knee osteoarthritis, which is mainly reflected in the differentiation of bone marrow mesenchymal stem cells into chondrocytes. Transforming growth factor β promotes the proliferation of chondrocytes, and platelet-derived growth factors can regulate the migration, differentiation, and mineralization of mesenchymal stem cells. Insulin-like growth factor 1, fibroblast growth factor 18, and bone morphogenetic protein can protect and repair articular cartilage. (2) Many studies have confirmed that intra-articular injection of bone marrow aspiration concentrate can not only alleviate the pain of patients with knee osteoarthritis, improve mobility, and reduce their dependence on painkillers, but also promote the regeneration of articular cartilage. (3) Bone marrow aspiration concentrate comes from autologous, has no immune rejection, is easy to make, and has low cost. It is an effective way to treat early knee osteoarthritis. Nevertheless, the mechanism of bone marrow aspiration concentrate in the treatment of knee osteoarthritis is still unclear and needs further research and exploration. [ABSTRACT FROM AUTHOR]

Bone marrow mesenchymal stem cells are a type of tissue stem cells with bone differentiation potential. They are the hot spot in medical research in the 21 st century. The proliferation and differentiation of BMSCs are closely related to postmenopausal osteoporosis( PMOP). Based on the theory of traditional Chinese medicine combined with modern medical research, this article explains the internal connection among kidney dominating the bone and producing the marrow-bone marrow mesenchymal stem cellspostmenopausal osteoporosis, and discusses the clinical application of kidney reinforcing and marrow-beneficial method in the treatment of PMOP, so as to explore the scientific and reasonable Chinese medicine prevention and treatment programs, to play the unique advantages of Chinese medicine in the treatment of PMOP, and to provide new ideas and method for the prevention and treatment of PMOP. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Osteoporosis ( OP) is one of the complications of spinal cord injury (SCI), which may seriously affect quality of life of the patients and cause heavy burden to their families. Based on the theory of traditional Chinese medicine and modern medical research, this paper expounds the internal relationship between kidney dominating bone and producing marrow and SCI-induced osteoporosis ( SIO), discusses the clinical application of reinforcing kidney and beneficial marrow in the treatment of SCI-induced osteoporosis, so as to explore a scientific and reasonable prevention and control plan by traditional Chinese medicine. The unique advantages of traditional Chinese medicine in the treatment of SCI-induced osteoporosis should be applied. New ideas and method in both theoretical innovation of kidney dominating bone and producing marrow and effective prevention and treatment of SIO with traditional Chinese medicine are provided. [ABSTRACT FROM AUTHOR]

Osteoporosis (OP) has become a major public health problem facing the whole world, especially with the acceleration of population aging in China, its prevention and treatment is urgent. In recent years, with the excavation and exploration of traditional Chinese medicine in China, many studies have found that Eucommia ulmoides Oliv, a kidney-tonifying traditional Chinese medicine, has obvious preventive and therapeutic effects on osteoporosis. Modem pharmacological research shows that the effective components of Eucommia ulmoides Oliv. can effectively prevent and treat osteoporosis by regulating estrogen level, expression of bone metabolism-related cytokines and osteoprotegerin, and comprehensive effect on proliferation and differentiation of osteoblasts, osteoclasts and bone marrow mesenchymal stem cells ( BMSCs). As a precursor cell of osteoblasts, BMSCs, exploring its differentiation mechanism is of great significance for guiding the prevention and treatment of osteoporosis. This article reviews the signal pathways related to the differentiation of BMSCs into osteoblasts induced by traditional Chinese medicine Eucommia ulmoides, in order to provide new ideas for the diagnosis and treatment of OP. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Postmenopausal osteoporosis(PMOP) represents the largest proportion of osteoporosis, and seriously affects the health of middle-aged and old women and their quality of life. Traditional Chinese medicine(TCM) has unique advantages in the treatment of PMOP, but the TCM diagnosis and treatment of PMOP mostly takes "kidney-bone" as the main theoretical basis, and often ignores the important role of "liver". Women with the liver as a congenital, therefore for elderly women, "treating from the liver" is particularly important. In this paper, the pathogenesis of PMOP was discussed based on the physiological functions of liver, such as hepatic main catharsis-free emotion, liver storing blood, liver-tendon, etc., so as to provide new ideas for the prevention and treatment of PMOP. [ABSTRACT FROM AUTHOR]

The theory of TCM inherits the treatment according to differentiation principle, emphasizing the integrity and unity of human beings as a whole body. The kidney governing bone and producing marrow is the congenital essence. The spleen governing muscle and filling with limbs is the postnatal source. They are interdependency to jointly maintain the normal physiological function of the human body. However, there is lack of objective molecular biology basis to explain its mechanism of action. The discovery of the OPG/RANK/RANKL signal transduction system is a milestone in the history of bone metabolism, which creates a new era of the research of prevention and treatment of postmenopausal osteoporosis (PMOP) with traditional Chinese medicine. The change of bone microscopic information is to express the effect of the system on the regulation mechanism of bone from the spleen and kidney. Based on the theory of spleen governing muscle and kidney governing bone, this paper reviews the etiology and pathogenesis of postmenopausal osteoporosis and the role of OPG/RANK/RANKL signaling pathway in bone metabolism, which aims to provide a scientific basis for the prevention and treatment of PMOP with traditional Chinese medicine from the molecular biological level, and to guide clinical practice better. [ABSTRACT FROM AUTHOR]

Objective To compare the efficacy of parathyroid hormone 1-34 (PTH) and alendronate ( ALN) in the treatment of osteoporosis combined with rheumatoid arthritis (RA) in women. Methods 98 female patients diagnosed with osteoporosis and RA after menopause were enrolled in our hospital from February 2017 to November 2017. Patients were divided into PTH group and ALN group according to the treatment plan. The two groups were treated with teriparatide or alendronate, respectively. The changes of bone mineral density and bone metabolism were observed after 6 months of treatment. Results After 6 months of treatment, the bone mineral density of lumbar spine increased significantly (P<0. 05). Compared with the ALN group, the mean percentage change of lumbar spine BMD in the PTH group was significantly higher at 6 months of treatment; while the femoral neck BMD was only significantly increased in the PTH group. Conclusion Parathyroid hormone (1-34) is more effective than alendronate in the short-term treatment of osteoporosis combined with rheumatoid arthritis in women. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical effect of percutaneous laser vaporization combined with duzhongyaotong pill in the treatment of lumbar disc herniation. Methods: 106 cases of patients with lumbar disc herniation who were treated in our hospital from April 2016 to April 2018 were selected and randomly divided into two groups. The control group was treated with percutaneous laser vaporization alone, and the observation group was treated with duzhongyaotong pill orally, 8 capsules each time, 3 times a day. The therapeutic efficacy, changes of VAS score, JOA score, serum interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α) levels before and after treatment were compared between the two groups. Results: After treatment, the effective rate of observation group was 88.68%(47/53), which was significantly higher than that of control group [73.58%(39/53)](P<0.05). After treatment, the VAS scores of both groups were significantly lower than those before treatment(P<0.05), while the JOA scores were significantly higher than those before treatment(P<0.05), and the VAS scores of observation group were significantly lower than those of the control group, and the JOA scores were significantly higher than those of the control group(P <0.05). The serum levels of IL-1β and TNF-α in both groups were significantly lower than those before treatment(P <0.05), and the serum levels of IL-1β and TNF-α in the observation group were significantly lower than those in the control group(P<0.05). No neurological injury or intervertebral disc inflammation occurred in the two groups. Conclusion: The clinical effect of percutaneous laser vaporization combined with duzhongyaotong pill in the treatment of lumbar intervertebral disc herniation was better than that of percutaneous laser vaporization alone, which can significantly improve the quality of life of patients and reduce the degree of pain, and its mechanism may be related to the reduction of serum inflammatory mediators IL-1β and TNF-α expression. [ABSTRACT FROM AUTHOR]

Osteoporotic fracture (OPF) is one of the most serious complications of osteoporosis, which seriously affects the health and quality of life of elderly patients. The spleen-muscle plays an important role in the development and degeneration of bone through its influences on blood circulation, nervous system and mitochondrial system. The theory of “spleen governing muscles” is a classical theory of Chinese medicine, which is consistent with the result of modern medical research. The dysfunction of the spleenmuscle can lead to decreased bone mass and decreased bone strength, which ultimately leads to OPF. This article is based on the theory of spleen governing muscles, from the starting point of spleen-muscle to investigate the correlation of spleen-muscles-bonesosteoporosis fracture, emphasizing the effect of spleen-muscle on the pathogenesis of OPF, and hope to provide theoretical basis for the prevention and treatment of OPF. [ABSTRACT FROM AUTHOR]

Osteoporotic fracture，one of the most serious complications of osteoporosis，seriously affects the health and quality of life in middle-aged and elderly patients． The idea of preventive treatment of a disease in traditional Chinese medicine is an important guiding ideology for disease prevention and control． This idea combines with the modern preventive medicine concept，the achievements of modern medical development in fracture prediction，and molecular biological mechanisms in signal pathways． It has deep significance in the prevention of osteoporotic fractures． This paper reviews based on the theory of preventive treatment of a disease，the origin of traditional Chinese medicine and the physiological and pathological characteristics of osteoporotic fractures， combined with the modern medical osteoporotic fracture prevention instruments and molecular biological mechanisms related signal pathways and other research result ． To explore the prevention and cure strategies of preventive treatment of a disease in the treatment of osteoporotic fracture，to improve people’s awareness to osteoporotic fracture prevention，and to realize the great goal of prevention and cure from the bud. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)