Search

Osteoarthritis (OA) is a common clinical chronic degenerative disease caused by the degeneration and loss of articular cartilage, which brings a heavy medical burden to patients and the country. The in-depth study of its mechanism is conducive to strengthen the treatment of OA. Recent studies have found that wingless type MMTV integration site family member 5A (Wnt5a) gene plays an important role in the pathogenesis and progress of OA. It can affect the independent pathogenesis of OA, such as aging, metabolic obesity, and trauma, and can participate in it through classical and non-classical Wnt signaling pathways. This paper reviews the role and mechanism of Wnt5a gene in OA, so as to provide benefit for related research. [ABSTRACT FROM AUTHOR]

Osteoarthritis (OA) is a chronic degenerative disease caused by aging, obesity, trauma, heredity and other factors, which is a difficult disease faced by orthopedic doctors in clinic, and brings a heavy burden to patients and families. Resveratrol is a natural compound with anti-inflammatory and antioxidant effects. It can affect cartilage aging, cartilage matrix metabolism, and cartilage injury in participate in the process of OA, which might be related to NF-KB, TLR4 and ERK signaling pathway. This paper reviews the research progress of resveratrol in the process of OA and its possible mechanism, so as to facilitate relevant research. [ABSTRACT FROM AUTHOR]

Cartilage injury is caused by inflammation, trauma, and tumor. Due to the anatomical factors of articular cartilage, its healing ability is poor. The preparation of tissue engineering materials to promote the repair of cartilage injury has attracted much attention. Magnesium and magnesium materials have attracted extensive attention because of their good biosafety, biocompatibility, degradability, and availability. They play an important role in the repair of cartilage injury such as osteoarthritis. This paper reviews the role and mechanism of magnesium and magnesium materials in the repair of articular cartilage injury. [ABSTRACT FROM AUTHOR]