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目的探究环状RNA hsa_circ_0002316（circOMA1）是否参与泌乳素瘤耐药调控及其作用机制是什么。方法通过RT-qPCR检测临床泌乳素瘤标本中circOMA1表达情况（5例敏感泌乳素瘤标本和12例耐药泌乳素瘤标本）。通过慢病毒载体构建稳定表达外源性circOMA1 MMQ细胞系模型进行体外实验，分为MMQ NC组及MMQ OMA1组。通过构建裸鼠皮下肿瘤模型进行体内实验，分为MMQ NC+卡麦角林（CAB）组、MMQ NC+溴隐亭（BRC）组、MMQ OMA1+CAB组、MMQ OMA1+BRC组。通过CCK8、Western blot、ELISA等表型实验检测circOMA1对耐药机制中的细胞增殖和泌乳素（PRL）分泌两个方面的影响。通过Western blot、ELISA、免疫组化等实验检测circOMA1对多巴胺受体表达的影响。通过TargetScan、CircInteractome等软件分析预测、 microRNA-145-5p（miR-145-5p） minic补救实验探究circOMA1调控多巴胺受体机制。结果RT-qPCR结果显示多巴胺受体激动剂（DAs）耐药泌乳素瘤中circOMA1表达升高（P＜0.01）。在细胞实验及裸鼠皮下肿瘤实验中，与MMQ NC组相比，MMQ OMA1组DAs敏感性降低，细胞增殖水平和泌乳素分泌水平升高（P＜0.05）。Western blot和免疫组化结果显示，MMQ OMA1组多巴胺2型受体（DRD2）表达下调，多巴胺5型受体（DRD5）表达上调，环3’，5’-单磷酸腺苷（cAMP）水平上调（P＜0.05）。此外，在MMQ OMA1组中miR-145-5p表达下调，kelch重复序列和BTB结构域蛋白7（KBTBD7）mRNA及蛋白表达水平上调（P＜0.05），然而MMQ OMA1组转染miR-145-5p minic后，KBTBD7表达下调，DRD2表达上调（P＜0.05），表明过表达miR-145-5p逆转了circOMA1对KBTBD7的促进作用。结论circOMA1通过miR-145-5p/KBTBD7轴下调DRD2表达，降低泌乳素瘤对DAs敏感性，并且调控多巴胺受体表达激活cAMP通路促进泌乳素合成释放，从而促进泌乳素瘤耐药性。

近年来，结构性磁共振成像（sMRI）和功能性磁共振成像（fMRI）被广泛应用于抑郁症研究。从结构形态学、结构网络、功能网络3个角度探索抑郁症患者的大脑异常，了解其发病机制，辅助医生临床诊断、治疗和预后。目前大量研究发现抑郁症患者的海马体、杏仁核出现不同程度的萎缩，脑网络的连接强度、图论属性等均出现显著异常，且出现异常的脑区对应于人的情绪调节、注意力和认知控制等功能，异常的程度与抑郁的严重程度呈现高度相关性。从不同角度对抑郁症的研究现状进行综述，并对未来的研究提出了建议。

机器学习根据历史数据的模式预测未来，近年来进行了大量研究并得到了应用，但在处理动态、非完整、非结构化信息上与人类相去甚远。为此，引入人的决策，结合机器学习、知识库，构建了一个人在回路的混合增强智能闭环系统。基于 Sawyer 协作机器人搭建了人机融合实验平台，设计了机器人抓取实验。实验结果表明，相比单一机器学习方式，在引入人类智能后，Sawyer在应对非结构化环境下的抓取任务中表现更佳。

针对目前冷链物流信息缺失、溯源难等问题，基于物联网技术及微服务系统架构，研究并设计端到端的冷链云服务系统，实现冷链物流全周期、不同业务场景数据监控等功能，解决现有冷链监测系统信息孤岛、数据无法共享等问题，达到冷链监控不断链的实际需求。冷链云服务系统包括智能监测终端、云服务管理平台及冷链管家App，可应用到医药、生鲜、水果、鲜花等领域，主要针对系统在医药冷链行业的应用，尤其是医药冷链行业的存储、运输、销售三大业务场景展开详细说明。设计的系统运行稳定，已被投入商业运营，且被众多医药行业用户认可。

【目的】对粘结托槽前后菌斑中变形链球菌数量的差异进行定量研究。【方法】采用自身对照法。每个患者分两阶段取样：粘结托槽前和粘结托槽后4周；取样牙位包括上4个切牙。设计针对变链菌的特异性引物和MGB探针，应用实时荧光定量PCR技术测定每毫克菌斑样本中变链菌的数量。【结果】同一患者粘托槽前后变链菌数值分别为5．31×10^6／mg和6．35×10^6／mg，其差别有统计学意义（P=0．0025）。【结论】患者粘结托槽后，菌斑中变链菌密度的明显升高，可能是正畸治疗中自垩斑发生率较高的原因之一。

Copyright of Journal of Atomic & Molecular Physics (1000-0364) is the property of Journal of Atomic & Molecular Physics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Based on the data of Kenya's four national population censuses, exploratory spatial data analysis, standard deviation ellipse, and population shift-share model were used to analyze the spatial pattern evolution characteristics of the population distribution of 47 administrative units in Kenya from 1989 to 2019. Then, this paper employed geographic detector to further analyze the influencing factors. The results show that: ① During the study period, the distribution pattern of population density in Kenya is relatively stable, showing high southwest and low northeast. ② There are obvious spatial differences in population offset growth in different cities, mainly positive offset growth and negative offset growth types. And the population distribution center is northwest of the capital Nairobi and continues to migrate southeast. ③ Natural and socio-economic factors jointly influence the spatial evolution pattern of population distribution in Kenya. Under the influence of elevation, climate, precipitation, economic development level and transportation infrastructure construction, the population is concentrated in a few areas along the southwest and southeast coasts of Kenya. Kenya has roughly formed a high-density population cluster centered on Nairobi, the national administrative center, Kisumu on the shores of Lake Victoria, and Mombasa, the largest port on the coast. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Graphics is the property of Journal of Graphics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aiming at the existing air suction hole tray seedling sowing machine in the face of more impurities and no pill granulation irregular small particle vegetable seeds there are suction holes clogging and lead to the decline in the accuracy of seed discharge technical problems. In this study, a vegetable seedling planter based on high-voltage electrostatic adsorption characteristics was designed by discarding the small aperture and long conductance suction holes. The dielectric insulating layer material is determined by theoretical analysis and simulation tests of potential contour distribution. The results show that: as the relative dielectric constant of the dielectric insulating layer gradually increases, the distribution of equipotential lines between the type hole and the seed box is gradually dense, the potential difference gradually increases, the electric field is gradually strengthened, and the electrostatic adsorption force on the polarised seeds gradually increases, and the adsorption state becomes more and more stable; Construct a mechanical model of electrostatic adsorption, clarify the main factors affecting the electrostatic adsorption force and their interrelationships. The results show that the main factors affecting the size of the effective electrostatic adsorption force in the pore are the output voltage of the electrostatic generator, the hole machining diameter, the material of the dielectric insulating layer, the relative permittivity of the seed layer, the spacing between the pore and the seed layer, and the material of the electrode sheath and the inner and outer diameters of the pore. And determine the electrical parameters and ranges affecting the seeding performance; A three-factor, three-level Box-Behnken centre combination test was carried out with the hole machining diameter, positive high-voltage electrostatic generator output voltage and tilt angle of the seed box bottom as test factors, and sowing pass index, reseeding index and leakage index as response indicators. The results showed that the order of influence of the test factors on the sowing compliance index was the output voltage of the forward high-voltage electrostatic generator, the hole machining diameter, and the tilt angle of the bottom of the seed box; and the order of influence on the reseeding index and the leakage index was the hole machining diameter, the output voltage of the forward high-voltage electrostatic generator, and the tilt angle of the bottom of the seed box. The interaction terms of the diameter of the pore processing and positive HVEG output voltage had significant effects on seeding pass index, reseeding index and leakage index. Mathematical models were obtained between the test factors and the response indicators. Applying Design-Expert 10.0.4 software to optimise the mathematical regression model with multiple objectives, the best parameter combinations were obtained as follows: the hole machining diameter 5.91 mm, positive high-voltage electrostatic generator output voltage 17.67 kV, and tilt angle of the bottom of the seed box 14.69°, and the sowing qualification index at this time was 91.13%, the reseeding index was 3.02%, and the omission index was 5.85%; In the seeding performance verification test, the seeding pass index decreased by 0.61 percentage points, the reseeding index decreased by 0.17 percentage points and the missed seeding index increased by 0.78 percentage points compared to the optimised results. The test error is within the permissible range, and the parameter optimization results are reliable and meet the technical requirements of precision sowing. The results of the study can provide a reference for the research and development of mechanical equipment for precision sowing of vegetable seeds with irregular small particles, and at the same time, provide an academic reference for the research of quantitative adsorption and rapid separation methods and equipment development of irregular small particles materials. [ABSTRACT FROM AUTHOR]

In order to explore the mesoscopic mechanism of rock damage and the characteristics of precursor to destruction, the shear failure acoustic emission test was carried out on carbonaceous shale, the phase-space reconstruction and correlation dimension calculation of the three acoustic emission parameters were carried out by Grassberger-Procaccia(G-P) algorithm, and the evolution law of correlation dimension in the whole process of carbonaceous shale destruction was analyzed by using fractal theory. The results show that the acoustic emission activity is active in different stages of rock deformation, and there is a calm period. The acoustic emission ringing count, energy, and amplitude sequences all have fractal characteristics, and the correlation dimensions of the three show the change law of “ ascending dimension-dynamic fluctuation-dimensionality reduction ” in the whole process of destruction. The dimensionality reduction phenomenon occurs before the destruction of the rock and ends after the destruction of the rock sample, so it can be used as the precursor information of the rock instability failure as the calm period, and the dimensionality reduction phenomenon of the associated dimension of the ringing count and energy is more significant and lasts longer, which is more suitable as the precursor information of the rock instability failure than the amplitude. [ABSTRACT FROM AUTHOR]

Copyright of China Rural Water & Hydropower is the property of China Rural Water & Hydropower Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of the Chinese Society of Agricultural Engineering is the property of Chinese Society of Agricultural Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Applied Chemical Industry is the property of Shaanxi Research Design Insitute of Petroleum & Chemical Industry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 系统性评价弯角椎体成形术治疗骨质疏松性椎体压缩骨折 (OVCF) 的有效性及安全性。方法 通过万方、中国知网、维普中文数据库、中国生物医学文献数据库、Embase、Web Of Science、PubMed、Cochrane Library 数据库检索弯角椎体成形术 (CVP) 、单侧椎体成形术 (UVP) 和双侧椎体成形术 (BVP) 治疗 OVCF 的相关文 献, 对纳入的文献进行 Meta分析, 比较三种手术方式的有效性和安全性, 包括视觉模拟疼痛评分 (VAS) 、功能障碍 指数 (ODI) 、手术时间、X线曝光次数、骨水泥注入量、骨水泥渗漏次数、骨水泥非理想分布率。结果　共纳入7篇文 献、共 610 例患者, 其中 CVP 201 例、UVP 215 例、BVP 194 例。Meta 分析表明, 与 UVP 患者比较, CVP 患者骨水泥注 入量增加 (MD=0.105, 95% CI为 0.049～0.160, P=0.0001), 骨水泥非理想分布率、骨水泥渗漏率降低 (RR=0.094, 95% CI 为 0.040～0.221, P=0.0001; RR=0.372, 95% CI 为 0.222～0.624, P=0.0001), 两者 VAS、ODI、手术时间、X 线曝光次数比较差异无统计学意义 (MD=-0.066, 95% CI为-0.167～0.036, P=0.204; MD=0.324, 95% CI为-1.025～ 1.673, P=0.638; MD=0.319, 95% CI 为 -0.450～1.087, P=0.416; MD=-0.033, 95% CI 为 -1.168～1.102, P= 0.954)。与BVP患者比较, CVP患者VAS、手术时间、X线曝光次数、骨水泥注入量、骨水泥非理想分布率、骨水泥渗 漏 率 降 低 (MD=-0.110, 95% CI 为-0.210～-0.010, P=0.031; MD=-16.726, 95% CI 为-17.503～-15.948, P= 0.0001; MD=-8.620, 95% CI为-9.702～-7.538, P=0.0001; MD=-1.533, 95% CI 为-1.600～-1.466, P=0.0001; RR= 0.324, 95% CI 为 0.126～0.834, P=0.0001; RR=0.366, 95% CI 为 0.216～0.620, P=0.0001), 两组 ODI 比较差异无 统计学意义 (MD=-0.394, 95% CI 为-1.878～1.091, P=0.603)。结论 CVP 治疗 OVCF 可以通过单侧入路优化骨 水泥的分布, 达到双侧入路的矫形效果, 与UVP和BVP相比疗效更好、安全性更高。 [ABSTRACT FROM AUTHOR]

Copyright of Journal of Chinese Mass Spectrometry Society is the property of Journal of Chinese Mass Spectrometry Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of the Chinese Society of Agricultural Engineering is the property of Chinese Society of Agricultural Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The impact of climate change is becoming increasingly urgent and severe. Meanwhile, global geopolitical situation remains tense, fueled by challenges such as economic downturn, energy crisis, debt crisis in developing countries, and intensifying competition among major powers. Against this backdrop, global climate governance faces multiple difficulties, and the leading channel for multilateral climate governance under the United Nations Framework Convention on Climate Change (UNFCCC) has seen setbacks. With carbon neutrality forming a broad political consensus around the world, different countries have launched a new round of competition and cooperation on green technology and industry, energy transformation and infrastructure construction in developing countries. Major country competition has shifted from competition on carbon emission space and development rights under the UNFCCC over the years to competition for climate-related rules, green standards, and the dominant position in the green industry chain. The scope of greenhouse gas emissions reduction has been further expanded to the international aviation and shipping industry, and nonstate actors are playing an increasingly important role in climate governance. In the future, China should continue to adhere to the multilateral process of global climate governance under the UNFCCC, actively participate in and lead the formulation of green rules, advocate the principle of “Common but Differentiated Responsibilities”, proactively assume international obligations commensurate with its national conditions, development stages, and capacities, and work with all parties to promote global climate governance in an effort to build a community with a shared future for mankind. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Shanghai Jiao Tong University (1006-2467) is the property of Journal of Shanghai Jiao Tong University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Railway Science & Engineering is the property of Journal of Railway Science & Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Data Acquisition & Processing / Shu Ju Cai Ji Yu Chu Li is the property of Editorial Department of Journal of Nanjing University of Aeronautics & Astronautics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To observe the application of 18F-FDG positron emission computed tomography （PET）/electronic computed tomography （CT）-guided percutaneous lung biopsy in the diagnosis of pulmonary space-occupying lesions. Methods Totally 325 patients with suspected pulmonary space-occupying lesions, including 102 patients who underwent percutaneous lung biopsy after 18F-FDG PET/CT high metabolism target localization （observation group） and 223 patients who underwent lung biopsy guided solely by CT （control group） were selected. Based on the pathological examination results of biopsy tissue combined with follow-up results as the clinical final diagnosis （gold standard), and after 18FFDG PET/CT localization, the detection rate, sensitivity, specificity, and accuracy of pathological diagnosis of biopsy tissues after percutaneous lung biopsy were calculated. Results ① The final clinical diagnosis showed that there were 84 cases of malignant lesions and 12 cases of benign lesions in 96 patients of the observation group. The pathological results of 96 patients' biopsy tissue showed there were 14 cases of benign lesions and 82 cases of malignant lesions. Among the 14 benign lesions, 2 were clinically diagnosed as malignant lesions and 12 were benign lesions. The final clinical diagnosis showed that there were 162 cases of malignant lesions and 34 cases of benign lesions in 196 patients of the control group. The pathological results of biopsy tissues from 196 patients showed there were 61 cases of benign lesions and 135 cases of malignant lesions. Among the 61 cases of benign lesions, 27 were clinically diagnosed as malignant lesions and 34 were benign lesions. ② The detection rate, sensitivity, specificity, and accuracy of pathological diagnosis in the observation group were 94. 1% （96/102), 97. 6% （82/84), 100% （12/12), and 97. 9% （94/96), respectively. The detection rate, sensitivity, specificity, and accuracy in the control group were 87. 8% （196/223), 83. 3% （135/162), 100% （34/34), and 86. 2% （169/196), respectively. Compared with the control group, the sensitivity and accuracy of pathological diagnosis in the observation group were higher （χ2 = 10. 856 and 9. 848, respectively； all P<0. 01）. Conclusion Compared with the simple CT guidance, 18F-FDG PET/CT high metabolic target localization can improve the accuracy of intraoperative localization and histopathological diagnosis in puncture biopsy. [ABSTRACT FROM AUTHOR]

Copyright of Feed Research is the property of Editorial Board of Feed Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the effects of Baduanjin combined with resistance exercise on glucose and lipid metabolism, oxidative stress and quality of life in elderly patients with type 2 diabetes (T2DM). Methods: 238 cases of elderly patients with T2DM who were treated in our hospital from April 2021 to May 2022 were selected. According to the method of random number table, they were divided into the control group (on the basis of conventional treatment, they received resistance exercise intervention, 119 cases) and the combined group (on the basis of the control group, they received Baduanjin intervention, 119 cases). The improvement of glucose and lipid metabolism, oxidative stress and quality of life in the two groups were observed. Results: 12 weeks after intervention, body mass index and waist hip ratio in the combined group were lower than those in the control group (P<0.05). 12 weeks after intervention, fasting blood glucose (FBG), 2 h postprandial blood glucose (2hPG) and glycosylated hemoglobin (HbAlc) in the combined group were lower than those in the control group (P<0.05). 12 weeks after intervention, high- density lipoprotein cholesterol (HDL-C) in the combined group was higher than that in the control group (P<0.05), while low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG) were lower than those in the control group. 12 weeks after intervention, malondialdehyde (MDA) in the combined group was lower than that in the control group, while superoxide dismutase (SOD) and catalase (CAT) were higher than those in the control group (P<0.05). 12 weeks after intervention, the scores of all dimensions of the MOS 36-item short-form health survey (SF-36) in the combined group were higher than those in the control group (P<0.05). Conclusion: Baduanjin combined with resistance exercise in elderly patients with T2DM can effectively improve the oxidative stress, glucose and lipid metabolism, and improve the quality of life of patients. [ABSTRACT FROM AUTHOR]

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Copyright of Chinese Journal of Refrigeration Technology is the property of Shanghai Society of Refrigeration and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal on Communication / Tongxin Xuebao is the property of Journal on Communications Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to explore the removal effect and degradation mechanism of the reactive black 5 dye in the aerobic granular sludge system. a constant working volume sequential batch reactor（SBR) was set up to cultivate aerobic granular sludge under alternative anaerobic and aerobic operating condition to treat synthetic azo dye wastewater.The removal efficiency of COD, NH+4-N and PO43--P and the removal load of reactive black 5 were measured in the SBR system, and the mechanism of azo dyes was further explored by high through-put sequencing of 16S rRNA gene.The results showed that the SBR system had a good effect in removing pollutants, the removal rates of COD, NH+4-N and PO43--P reached 90%, 95% and above 95% at the end of culture period, and the removal of azo dye maintained around 0.005 kg·（kg·d）-1.The azo double bond of the reactive black 5 dye mainly broke at the anaerobic stage, and the intermediates containing benzene and naphthalene rings were degraded at the aerobic stage.High-throughput sequencing analysis of the 16S rRNA gene showed that azo dye increased the nitrogen load of the SBR system, thus increasing the abundance of nitrifying bacteria and the bacteria which had the function of denitrifying or degrading aromatic substances genera such as Paracoccus, Azoarcus and Thauera. [ABSTRACT FROM AUTHOR]

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