Search

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the mechanism of glucocorticoid-induced osteoporosis (GIOP) by comparing the changes of bone mineral density (BMD), pathological tissue, and the protein expression of leptin and vascular endothelial growth factor (VEGF) before and after modeling. Methods Rats received intramuscular injection of dexamethasone sodium phosphate (Dex) on their vastus for 8 weeks to establish the GIOP model. The rats were sacrificed after 8 weeks. Bone mineral density (BMD) and HE staining were performed on the right femur and tibia to determine the optimal modeling dose. The protein expressions of leptin and VEGF in rats of SHAM and DEX group were detected using immunohistochemistry and Western blotting. Results The results of BMD and HE staining showed that 2.5 mg/kg of Dex was the optimal dosage for GIOP modeling. The expression of leptin and VEGF in Dex2.5 mg/kg group decreased significantly (P<0.05) compared to those in Sham group, and the difference was statistically significant. Conclusion The effect of glucocorticoid on the induction of osteoporosis is through inhibition of leptin and VEGF expression, leading to the inhibition of angiogenesis and osteogenic differentiation. The present study indicates that leptin and VEGF might be potential targets for the pathogenesis of osteoporosis. [ABSTRACT FROM AUTHOR]

Objective To explore the influencing factors related to the quality of life in patients with chronic heart failure (CHF), and provide a reference basis for the prevention and care of such patients. Methods The information of 182 patients who visited Guang zanmen Hospital of China Academy of Chinese Medical Sciences? Dongfang Hospital of Beijing University of Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine and other hospitals during 2010 - 2012 were selected to construct a database, and statistical analysis such as frequency, difference analysis and multiple regression were performed with SPSS 23. 0 software. Results The effect of different factors on the scores in different dimensions of the SF-36 scale showed that gender had a significant effect on physical functioning (P =Q. 015), vitality (P = Q. 007), mental health (jP =0. 017), and social functioning (P =0. 020); age had an effect on physical functioning (尸=0. 013), role-physical (P =0. 02), and role-emotional (P = Q. 007) ; education level had an influence on physical functioning (P <0. 001 ), vitality (jP =0. 019 ), role-emotional {P

Objective To evaluate the efficacy and safety of Rhizoma Drynariae total flavonoids (Qiangu Capsule) in the treatment of postmenopausal osteoporosis rats, and to explore the innovative and safe applications of Rhizoma Drynariae total flavonoids (Qiangu Capsule) in the treatment of postmenopausal osteoporosis. Methods Seven commonly used databases were went through to screen for randomized controlled trials of total flavonoids (Qiangu Capsule) for the treatment of postmenopausal osteoporotic rats. The SYRCLE animal test bias risk assessment tool was used to evaluate the quality of included studies. Results After preliminary screening and rigorous evaluation, 12 studies were included, including a total of 246 samples, and the quality of the included literature was generally low. The results of meta-analysis showed that in rats Rhizoma Drynariae total flavonoids (Qiangu Capsule) could improve the bone mineral density at lumbar spine (WMD=0.03, 95%CI 0.02-0.04, P<0.001) and femur (WMD=0.03, 95%CI 0.02-0.03, P<0.001), as well as serum BGP, ALP and CTX levels, but the effect on serum calcium and serum phosphorus levels and the dose-effect relationship still need more animal experiments to explore and verify. Safety aspects were not reported in the literature. Conclusion The total flavonoids (Qiangu Capsule) could improve bone mineral density and some blood bone metabolic markers in postmenopausal osteoporosis rats to some extent. However, given the limitations of the number and quality of the included studies, the above conclusions need to be verified by more high-quality studies. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To provide evidence of the effects of total flavonoids from Rhizoma Drynariae(TFRD)on postmenopausal osteoporosis(PMOP).Method CNKI, China biomedical database, Chinese Science and Technique Journals Database, Wanfang database, the Cochrane Library, PubMed, and EMBASE had been retrieved by computer to collect data of randomized controlled clinical trials on the effects of Qianggu Capsule(the main component is TFRD) in treatment of PMOP.The retrieval time was from database establishment to November 2017.System evaluation and meta-analysis were performed by RevMan 5.3. Results Six references were included, including a total of 8 researches.In terms of clinical efficiency and improving bone mineral density of femur, Qianggu Capsule combined with conventional treatment was better than conventional treatment, the Meta result were RR=1.50,95% CI(1.04,2.17),P=0.03 and. Compared with the conventional treatment group, the difference was not statistically significant in improving bone mineral density of lumbar spine or hip and calcium, phosphorus, alkaline phosphatase, osteocalcin, and other biochemical indicators in blood. Its side effects included constipation, dry mouth, nausea and gastrointestinal reactions. But after treatment with symptomatic treatment, drug withdrawal was needless. Conclusion There is a lack of strong evidence to support that TFRD can play a fundamental role in PMOP.Although compare with conventional treatment, there is no obvious advantage in improving bone mineral density and calcium, phosphorus, alkaline phosphatase, osteocalcin, and other biochemical indicators in blood, but clinical research evidence shows that it has a certain effect in improving the patient’s symptoms, and has good safety. [ABSTRACT FROM AUTHOR]

Objective To evaluate the efficacy and safety of acupuncture in the treatment of postmenopausal osteoporosis(PMOP). Methods Six Chinese and English databases were searched electronically, and the retrieval date was up to November 2017. According to the Cochrane Hand book 5.3, the quality of the research included in this study was assessed. Meta-analyses were performed using Revman 5.3 Software. Results A total of 10 articles were included, including 710 patients, with 354 cases in the trial group and 356 cases in the control group. Meta-analyses showed that: ①Acupuncture compared with conventional therapy(CT) [RR=1.36, 95% CI(1.18, 1.57), Z=4.34, P<0.0001], Acupuncture + CT compared with CT [RR=1.31, 95% CI(1.14, 1.50), Z=3.77, P=0.0002], indicating that Acupuncture and Acupuncture + CT both could improve clinic efficiency; ②Acupuncture compared with CT [MD=-2.36, 95% CI(-4.20,-0.53), Z=2.53, P=0.01], Acupuncture + CT compared with CT [MD=-1.61, 95% CI(-2.06,-1.16), Z=7.01, P<0.00001], indicating that both Acupuncture and Acupuncture + CT all could reduce pain degree. Conclusion Compared with conventional treatment alone, acupuncture or acupuncture combined with conventional therapy can improve the effective rate and pain symptoms. It is worthy of clinical application. However, in view of the limitations of the included literature, there is a need for more high-quality, large sample, multicenter, well-designed randomized controlled trials in future research, to further support and enhance the effectiveness and safety of acupuncture for postmenopausal osteoporosis. [ABSTRACT FROM AUTHOR]

Objective To evaluate the efficacy and safety of Xianling Gubao capsule in the treatment of postmenopausal osteoporosis. Methods Seven electronic databases (from the date of establishment to November 2017) were retrieved. The literatures were screened according to the inclusion criteria and exclusion criteria. All the trials were assessed according to the Cochrane Handbook 5. 1 for Systematic Reviews of Intervention and the analyses was performed using RevMan5. 3 Software. Results A total of 1 779 articles were retrieved, 16 papers were selected, and 19 original studies were included, with a total sample size of 1 492 cases. Meta-analysis showed that the efficacy of Xianling Gubao capsule alone in improving bone mineral density of the lumbar vertebrae was superior to that of routine treatment (MD 0． 08, 95% CI 0． 03 to 0． 14). Xianling Gubao capsule combined with routine intervention was better than routine treatment in terms of improving effective ratio (OR 3． 35, 95%CI 1． 86 to 6． 05) and pain (MD -1． 71, 95% CI -2． 39 to -1． 03). The curative effect of single routine intervention plus Xianling Gubao capsule was better than that of single routine intervention in bone mineral density of the lumbar vertebrae (MD 0． 06, 95%CI 0． 04 to 0． 07). Xianling Gubao capsule combined with routine intervention was superior to routine interventions in improving hip bone mineral density (MD 0． 08, 95%CI 0． 03 to 0． 14). Conclusion Xianling Gubao capsule is effective in improving bone mineral density of the lumbar vertebrae, increasing clinical effective rate, and improving pain. However, the advantage in improving hip bone density is not obvious. The total treatment course may be an important influencing factor. Xianling Gubao capsule combined with single anti-osteoporosis drug has synergistic effect, but the synergistic effect is not obvious when combined with two or more anti-osteoporosis drugs. [ABSTRACT FROM AUTHOR]

Objective　To construct a risk predictive tool of early osteoporotic fractures according to the characteristics of 40-65- year-old females and the Chinese medical syndromes. Methods　Data of the risk factors and Chinese medical syndromes of 1 823 40-65-year-old women, who were in East District Beijing and Xuhui District Shanghai, were collected using registration method . The observation continued for 3 years. The data were balanced using SMOTE over stratified method . The risk factors and Chinese medical syndromes were screened base on the strategy tree model. The risk evaluation tool was established. Results　The C4． 5 calculation method was used as tool to establish the prediction model. The risk factors of fragile fractures in high risk patients were firstly screened out. The predictive model was then established. Due to the small sample size, cross-validation was adopted in the censor setting. Expert was selected in Mode. The purity of trimming was set to 75, and overall trimming was adopted.According to the growth and trimming rules, the stratified tree model established included 5 layers, 19 censor points, and 6 explanatory variables. The parameters were bone mineral density, dizziness, meat, number of productions, blurred vision, and fatigue, in order of importance. After the stratification of each influencing factor by layer, the proportion of the final fracture population accounted for 13%. The prediction probability of the prediction model was used to draw the subject’s working characteristic curve, and the result showed that the area under the curve was 0． 871 (95% CI = 0． 8226 - 0． 9211). Conclusion 　Based on the demographic characteristics of Beijing and Shanghai, the stratification model of osteoporotic fractures in women aged 40 to 65 years was established. [ABSTRACT FROM AUTHOR]

To establish an early risk prediction tool for osteoporotic fractures that combines demographic risk factors and TCM symptoms in females aged between 40 and 65 years in Beijing and Shanghai． Methods In this study，risk factors and TCM symptoms of 1129 women aged 40 to 65 years at high risk of osteoporosis were collected in Dongcheng District of Beijing and Xuhui District of Shanghai from March to August 2009 using a registered study method ． Observational registration continued for three consecutive years． The SMOTE oversampling algorithm was used to balance the data． Group Lasso's logistic regression model was used to screen for risk factors associated with osteoporosis and TCM symptoms，and a risk assessment tool for osteoporotic fractures was established． Results Based on the grplasso package of R 3. 3. 3 software，we studied risk factors of postmenopausal osteoporotic fractures and TCM syndrome factors at different λ levels． Finally，combining mathematics and medical science，we believe that the variables selected are the best when λ = 0. 0235． The specific group variables include: bone mineral density，age， food type，height，menstruation，number of births，and liver and kidney yin deficiency． Further，based on the logistic regression model，osteoporotic fracture prediction tools were derived: P = - 1. 88 + 0. 437* BMD + 0. 289* age + 0. 023* rice noodles - 0. 007* dairy products - 0. 096* soy products - 0. 128* meat - 0. 084* fish - 0. 007* fresh vegetables - 0. 018* eggs + 0. 047 * seaweeds + 0. 048* height - 0. 035 * whether became shorter - 0. 081 * menarche age + 0. 171 * whether menopause + 0. 121* menopause years + 0. 039* number of pregnancy + 0. 192* number of birth - 0. 056* whether the uterus and ovary were resected + 0. 05* fever of hands and feet - 0. 094* night sweat + 0. 008* soft legs + 0. 15* dizziness - 0. 048* blurred vision - 0. 045* dry eyes - 0. 089 * bad heat + 0. 08 * hair loss + 0. 034 * loose teeth - 0. 101 * bitter mouth + 0. 004 * irritable + 0. 054* afternoon hot flash - 0. 056* insomnia + 0. 019* dreaminess and easily frightened - 0. 02* chest thrush + 0. 137* lower limb spasm． The receiver operating characteristic curve was plotted against the predictive probability of the predictive model． The result showed that the area under the curve was 0. 8775 ( 95% CI = 0. 8412 - 0. 9138) ． Conclusion A preliminary risk prediction tool for osteoporotic fractures in 40 to 65-year-old females based on the demographic characteristics of Beijing and Shanghai was established． [ABSTRACT FROM AUTHOR]

Objective To summarize the types，advantages，and disadvantages of risk prediction tools for osteoporotic fractures， so as to provide the basis and reference for the follow-up clinical research and clinical research． Methods From the perspective of common diagnostic techniques and risk assessment tools for osteoporotic fractures，the clinical diagnosis techniques of osteoporotic fractures and the commonly used risk assessment tools nationally and internationally were reviewed． Ｒesults In the aspect of diagnosis technology，dual energy X-ray absorption measurement technology，quantitative ultrasound technology，quantitative CT technology，and nuclear magnetic resonance technology were mainly used． They had advantage in accuracy and intuition but had defects in high cost and radiation． In the simple tools for fracture risk prediction，the International Osteoporosis Foundation Assessment Tool，the Garvan nomogram assessment tool，the Q Fracture C algorithm，the Asian osteoporosis self-screening tool， and the Beijing Friendship Hospital Osteoporosis Self-Assessment Tool were used． They had great advantage in easy use，but had defects in sensitivity，specificity，and extrapolation． In addition，traditional Chinese medicine risk assessment model based on the characteristics of symptoms and signs or TCM syndrome could be used in the early prevention of osteoporotic fractures． Conclusion The diagnostic technique and risk assessment tool of osteoporotic fractures are increasing day by day． However，it is not common to adapt to the characteristics of high risk population of osteoporotic fractures in China． Ｒisk prediction tools for Chinese population should be constructed． [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)