仙灵骨葆胶囊治疗绝经后骨质疏松症有效性的系统评 价和Meta 分析.

Objective To evaluate the efficacy and safety of Xianling Gubao capsule in the treatment of postmenopausal osteoporosis. Methods Seven electronic databases (from the date of establishment to November 2017) were retrieved. The literatures were screened according to the inclusion criteria and exclusion criteria. All the trials were assessed according to the Cochrane Handbook 5. 1 for Systematic Reviews of Intervention and the analyses was performed using RevMan5. 3 Software. Results A total of 1 779 articles were retrieved, 16 papers were selected, and 19 original studies were included, with a total sample size of 1 492 cases. Meta-analysis showed that the efficacy of Xianling Gubao capsule alone in improving bone mineral density of the lumbar vertebrae was superior to that of routine treatment (MD 0． 08, 95% CI 0． 03 to 0． 14). Xianling Gubao capsule combined with routine intervention was better than routine treatment in terms of improving effective ratio (OR 3． 35, 95%CI 1． 86 to 6． 05) and pain (MD -1． 71, 95% CI -2． 39 to -1． 03). The curative effect of single routine intervention plus Xianling Gubao capsule was better than that of single routine intervention in bone mineral density of the lumbar vertebrae (MD 0． 06, 95%CI 0． 04 to 0． 07). Xianling Gubao capsule combined with routine intervention was superior to routine interventions in improving hip bone mineral density (MD 0． 08, 95%CI 0． 03 to 0． 14). Conclusion Xianling Gubao capsule is effective in improving bone mineral density of the lumbar vertebrae, increasing clinical effective rate, and improving pain. However, the advantage in improving hip bone density is not obvious. The total treatment course may be an important influencing factor. Xianling Gubao capsule combined with single anti-osteoporosis drug has synergistic effect, but the synergistic effect is not obvious when combined with two or more anti-osteoporosis drugs. [ABSTRACT FROM AUTHOR]