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To analyze the macroscopic distribution characteristics of global wave, based on the FHDI-GNWM global wave data from 2011 to 2015, a study was conducted on the global significant wave height Hs, spectral peak period Tp, and main wave direction Dmain. The study shows that the global average of significant wave height Hs generally exhibits a characteristic of being greater in the southern hemisphere than in the northern hemisphere, and in the southern hemisphere, there is an obvious high- value area of significant wave height Hs with an average value greater than 3.6 m, which corresponds to the Antarctic Circumpolar Current region. There are significant differences in the macroscopic distribution characteristics of wave height for the major oceans worldwide, such as the Northwest Pacific, East Pacific, North Atlantic, South Atlantic, and Indian Ocean. The average spectral peak period Tp in most of the world's oceans is greater than 12 s, and Tp on the west coast of each continent is significantly greater than on the east coast. The distribution pattern of the primary wave direction worldwide is not obvious, and there are significant differences in the main wave direction in different sea areas. [ABSTRACT FROM AUTHOR]

The experimental purpose is through investigating the effects of combined application of urea on dry matter, nitrogen accumulation, transport and yield of maize, to provide a theoretical basis for mining a reasonable nitrogen fertilizer for high yield of maize. The field experiment was conducted in 2016 and 2018 with a single factor randomized block design. Five treatments were set in the southern mountainous area of Ningxia. CK has no nitrogen application during whole growth season of maize. T1 was applied with 150kg·ha-1 conventional urea base and 75kg·ha-1 conventional urea topdressing in large bell stage. T2 was based on 75kg·ha-1 conventional urea and 75kg·ha-1 controlled-release urea and 75kg·ha-1 conventional urea in large bell stage. T3 consists of 75kg·ha-1 conventional urea based and 150kg·ha-1 controlled-release urea based, T4 is a basal application of controlled release urea of 225kg·ha-1. The results showed that the combined application of conventional urea and controlled-release urea could significantly increase the yield compared with CK. Under T3 treatment, the 2-year average yield was higher than that of single application of conventional or controlled-release urea, and reached the maximum in each treatment. Combined application increased the growth rate of leaf area index (LAI) and leaf area index (LAI) in early growth period, but slowed down the decline rate of LAI in late growth period. Compared with CK and T1, controlled release urea treatment significantly increased dry matter accumulation and grain nitrogen accumulation at mature stage. The dry matter transfer before anthesis was low in the treatment with controlled release urea, but it mainly increased the dry matter accumulation after anthesis and the contribution rate of dry matter accumulation after anthesis to the dry matter accumulation of grain, and it increased first and then decreased with the increase of controlled release urea content. Compared with single application of conventional urea, controlled release urea treatment increased nitrogen utilization rate(REN), nitrogen agronomic utilization rate(AEN), nitrogen partial productivity(PFPN) and fertilizer contribution rate(FCR), and T3 had the highest increase. Based on two years experiment results, applying controlled release urea to conventional urea at a ratio of 2:1 may save labor and increase maize yield. [ABSTRACT FROM AUTHOR]

In May 2023, the American Association for the Study of Liver Diseases (AASLD) published AASLD Practice Guidance on Prevention, Diagnosis, and Treatment of Hepatocellular Carcinoma (2023) online. The guidance mainly focuses on the prevention, diagnosis, and treatment of hepatocellular carcinoma (HCC) and provides corresponding suggestions and guidance for the problems existing in current clinical practice. The guidance emphasizes the importance and target population of HCC screening, specifies the diagnostic criteria and methods for early HCC, highlights the role of surgical treatment and related precautions in the treatment of HCC, and mentions the use of other treatment methods (such as radiotherapy, ablation, interventional therapy, and targeted therapy) and their own advantages and disadvantages. In addition, the guidance also introduces the details of HCC followup, such as examination items and frequency. The author’s team makes an excerpt of this guidance and systematically introduces the various key points for evaluation and related recommendations for clinical management, in order to provide a basis for the clinical management and decision- making of HCC patients from the aspect of evidence－based medicine. [ABSTRACT FROM AUTHOR]

【Objective】The present paper aimed to explore which proportion of nitrogen and phosphorus fertilizer combined with drip irrigation water and fertilizer integration in the Yellow River Diversion Irrigation Area can promote the accumulation and transfer of spring maize dry matter in Yinchuan Plain, and its effects on fertilizer utilization rate and yield, so as to provide a basis for the integration of drip irrigation water and fertilizer for spring maize in the Yellow River Diversion Irrigation Area. 【Method】The experiment was carried out in the Yinchuan Plain of the Yellow River Irrigation Area from 2019 to 2020. The maize variety Yinyu 274 was used as the material. The conventional application rates of local nitrogen and phosphorus fertilizers were 417 and 142.50 kg/hm². The conventional application rate of 70% nitrogen and phosphorus fertilizer was 291.90 and 99.75 kg/hm2. The conventional application rates of 130% nitrogen and phosphorus fertilizer were 542.10 and 185.25 kg/hm2. Six treatments with different proportions of nitrogen and phosphorus fertilizers were set up as T1 （N 0, P 0）, T2 （N 100%, P 70%）, T3 （N 100%, P 100%）, T4 （N 70%, P 100%）, T5 （N 130%, P100%）, T6 （N 100%, P 130%）. The effects of different ratios of nitrogen and phosphorus combined application on the dry matter accumulation, dry matter transport, grain contribution rate, nutrient utilization rate and yield of maize under drip irrigation, water and fertilizer integration were analyzed.【Result】The combined application of nitrogen fertilizer 291.9 kg/hm2 and phosphorus fertilizer 142.50 kg/hm² under the combined application of six kinds of nitrogen and phosphorus fertilizers had the best overall effect. The absorption of phosphorus and nitrogen by maize was significantly higher than that of other treatments. The nutrient requirements of maize throughout its growth period were satisfied. Compared with other treatments, the dry matter accumulation increased by 6.28%-22.90%, and the dry matter transport and grain contribution rate increased by 4.60%-11.10%. Compared with conventional combined application, nitrogen fertilizer utilization rate, phosphate fertilizer utilization rate, nitrogen fertilizer partial productivity and phosphate fertilizer partial productivity were significantly increased by 52.23%, 18.92%, 57.07% and 9.95% in T4 treatment. It can also significantly improve the corn ear formation rate, the number of grains per ear, and the weight of 100 kernels, thereby increasing the yield. The yield could be increased by 8.34%-9.95% compared with the conventional nitrogen and phosphorus application, and the maximum yield was 21 916.39 kg/hm².【Conclusion】The combined application of nitrogen fertilizer 291.90 kg/hm² and phosphorus fertilizer 142.50 kg/hm² under drip irrigation water and fertilizer integration in the Yellow River Diversion Irrigation Area can significantly increase the dry matter accumulation before and after flowering, and improve the dry matter transport, transport rate and contribution to seeds, and improve N fertilizer utilization, phosphorus fertilizer utilization and N fertilizer bias productivity, thus increasing maize yield. [ABSTRACT FROM AUTHOR]

Hypercrosslinked polymer (HCP) is a class of microporous organic polymer connected by light elements (C, H, O, and N) through covalent bonds. In order to efficiently adsorb soluble organic dyes in water treatment, here, an ionic HCP (HCP-SO3Na) was prepared through an efficient Friedel-Crafts reaction from sodium 4-(phenylamino)benzenesulfonate and benzene in the presence of formaldehyde dimethyl acetal and anhydrous FeCl3. A series of characterizing techniques such as elemental analysis, infrared spectroscopy, N2 adsorption/desorption analysis, solid-state 13C nuclear magnetic resonance spectroscopy and thermogravimetric analysis were employed to characterize the structure and thermal property of the ionic polymer. It was found that HCP-SO3Na was an amorphous microporous polymer with large specific surface area and high thermostability. The specific surface area and micropore area were 587 m2/g and 411 m²/g, respectively. The adsorption of HCP-SO3Na for the organic dye of Rhodamine B demonstrated the ―SO3Na groups distributing uniformly in the polymer could increase the saturation capacity of HCP. The maximum adsorption capacity was up to 431 mg/g. The adsorption process conformed to kinetic pseudo-second-order model and Langmuir model. HCP-SO3Na can be easily recovered and reused five times without significant loss of activity. [ABSTRACT FROM AUTHOR]

目的 探讨信息化输血系统在手术室输血管理中的应用,为输血科工作走上高质量、标准化的 轨道提供参考。方法 选取该院2019年5月至2021年5月收治的100例行手术治疗且术中输血的患者,其中 应用常规输血系统的50例患者作为对照组,应用信息化输血系统的50例患者作为观察组,比较2组申请输血 平均耗时、输血前核对规范率、输血记录单书写规范率、血制品交接规范率。结果 观察组申请输血平均耗时 短于对照组(P <0.05);2组输血前核对规范率比较,差异无统计学意义(P >0.05);观察组输血记录单书写规 范率、血制品交接规范率均高于对照组(P <0.05)。结论 信息化输血系统可有效缩短申请输血耗时,提高输 血记录单书写规范率和血制品交接规范率,提升工作效率和管理质量,在输血管理工作中有较高的应用价值。 [ABSTRACT FROM AUTHOR]

Aiming at the strong kinematic coupling problem of parallel mechanism, a novel uncoupled rotational parallel mechanism with two degrees of freedom was proposed. Its kinematical output characteristics were analyzed and mobility was calculated in terms of the position and orientation characteristics method. According to the actuated wrench screw theory and the closed vector approach, mathematical models of the posture and the angular velocity of the mechanism were established. Singularity analysis was performed based on the linear dependence of the kinematic screw system and constraint screw, respectively, and all singular configurations were given as well. The expression mapping the kinematical conditioning index and the structural factor, the input angular displacement was deduced. Structural condition of the fully-isotropic performance for the mechanism was discussed in detail. Finally, kinematical simulation of the mechanism was carried out. The results indicate that the mechanism has the uncoupled kinematics characteristics. Especially, when the structure size of the mechanism meets certain requirement, the velocity Jacobian is an identical matrix, therefore, the mechanism will show the fully isotropic performance. [ABSTRACT FROM AUTHOR]

Open search can identify all modifications of masses within a given wide precursor mass tolerance window. But open search does not account for modified fragment ions when matching peptide with spectrum, resulting in reduced sensitivity compared to traditional variable modification searching. Inserting complementary ions is an intuitive strategy to address this weakness. In this study, different spectrum processing methods making use of complementary ions were investigated. DeconTop20, which deisotope and deconvolute the spectrum, then adding the top 20 peaks’ complementary ions, was shown to be the best method for open search. The identification of peptides for open search relies only on the match between peptide fragment ions and MS/MS spectrum peaks, the filter power of precursor mass is ignored, which makes open search less sensitive than close search and more dependent on the resolution of tandem mass spectrum. Even using DeconTop20, the identification sensitivity of open search decreases rapidly when the resolution of mass spectrometry decreased. Clearly, the conventional complementary ion based method is not efficient to improve the identification sensitivity for low resolution data. Complementary ion spectrum is the spectrum composed of all the complementary ions of its original spectrum, which contains equivalent peptide-fragment information. The probability for a spectrum and its complementary ion spectrum matched to the same decoy peptide sequence is much lower than they matched to the same target peptide sequence. Based on this principle, a complementary ion spectrum strategy was proposed to improve the sensitivity of the open search. In this strategy, only the identical peptides identified by both the complementary ion spectrum and its original spectrum were considered as a valid match. In this study, the average ratio for a spectrum and its complementary ion spectrum match to the same decoy peptide sequence was 15%, which meant 85% false positives matches could be filtered out with this constraint, and a great increase of identification number were achieved under given false discovery rate. The sensitivity of this strategy increases significantly compared to conventional open search as the fragment ion tolerance increases. When applying 0.05 u fragment ion tolerance, the numbers of peptide-spectrum matches and peptides with 1% FDR increased by 40% and 42%, respectively; if 0.5 u fragment ion tolerance was used, the increments get to 116% and 97%. Clearly, this strategy can greatly reduce the dependence of open search on the resolution of mass spectrometry. [ABSTRACT FROM AUTHOR]

To analyze the macroscopic distribution characteristics of different exceedance probability wave heights in global waves, based on the five-year FHDI-GNWM global wave data from 2011 to 2015, the spatial macroscopic distribution patterns of different exceedance probabilities significant wave heights Hs worldwide were studied. The research shows that Hs with different exceedance probabilities exhibit obvious strong extremes and weak middles globally. For the Northwest Pacific, North Atlantic, and South Atlantic, Hs with different exceedance probabilities show a "first increase then decrease" trend with increasing latitude. For the Eastern Pacific, Hs with different exceedance probabilities exhibit a distinct pattern of being strong in the south and weak in the north, forming a distinct high-value zone near 55毅S. For the Indian Ocean, a distinct high-value zone is formed near 50毅S, and then decreases northward along the latitude zone. [ABSTRACT FROM AUTHOR]

Curcumin is a polyphenol extracted from the rhizome of Rhizoma Curcumae Longae with anti - inflammatory, antioxidant, and antitumor effects. It can also increase the sensitivity to chemoradiotherapy and protect hepatic and renal function. It is involved in the regulation of various signaling pathways and the expression of oncogenes and thus may become a potential anti - tumor drug for pancreatic cancer. This article reviews the mechanism of action of curcumin in inhibiting the proliferation and inducing the apoptosis of pancreatic cancer cells and inhibiting the signaling pathways involved in pancreatic cancer. [ABSTRACT FROM AUTHOR]

Objective Through the comprehensive geriatric assessment， the incidence of anxiety and related risk factors of the elderly hypertensive patients in the general hospital are understood and the basis for clinical intervention is provided．Methods We randomly selected the patients with primary hypertension diagnosed in the Department of Geriatrics in our hospital as the research objects. The elderly patients were evaluated comprehensively. The Hamilton Anxiety Scale (HAMA) was used to assess the incidence of anxiety in hypertensive patients and to identify the related risk factors．Results A total number of 317 elderly hypertensive patients were enrolled in this study. The age was 60~96 years old. The average age was(82.6 ± 6.4) years old. Among all the participants，173 were men (54.6%) were male and 144 were women (45.4%) were female．The incidence of anxiety mong all pecrticipants was 27.1%(86/317)，with 10.7%(34/317)in male and 16.4% (52/317)in femde．The independent risk factors for hypertension and anxiety in the elderly were 24 hours average blood pressure，disability and insomnia(p＜0.05) ．Conclusions Multiple factors can effect anxiety symptoms of inpatients.Using CGA can detect potential problems in early stage，and develop personalized intervention measures to improve the quality of life of the elderly. [ABSTRACT FROM AUTHOR]

Objective To develop a rapid method for the identification of inactivated C. albicans by surface-enhanced Raman spectroscopy (SERS). Methods Live C. albicans cultures were exposed to heating, formaldehyde and fungicidal drug (amphotericin B). The corresponding SERS spectra were acquired for the investigation and comparison. Results The spectra acquired with three different inactivation methods exhibited similar features of dead C. albicans, which showed significant difference from the spectra of the live culture. Conclusion This SERS method can identify the inactivated C. albicans rapidly. Hopefully it will provide a convenient tool for quick identification of other inactivated pathogenic microorganisms. [ABSTRACT FROM AUTHOR]

The collecting machinery of mulching plastic film offers an important technological means to curb the farmland residue pollution. The main method of residual film recycling in Xinjiang is the raking-film working. Due to the complex cotton field environment and the poor raking film effect of whole profiling of the used plastic film collector, the raking film tooth can not simultaneously carry out the monomer film collecting with copying with different cotton field terrain, which causes a low collecting rate during the process of residual film recycling. For the problem, this paper proposed a collecting-film mechanism of the profiling of the monomer. The theoretical design and mechanical analysis of the mechanism of collecting film were carried out. With the method of complex vector, the profiling-mechanism dynamics model was established, which involved the relationship between the reacting force of soil to land wheel of profiling and the spring-tooth resilience force. Based on the establishment and analysis of dynamics model, the collecting-film influencing factor could be initially determined. And the relevance of the spring-tooth stress states and the raking-film mechanism's operating condition was further explored. In order to confirm the operation parameters of the device of collecting film, the experiment of the response surface with 5 levels and 3 factors was accomplished on the soil bin trolley test-bed with the spring tooth of the raking film. Three test parameters, i.e. spring tooth number, test-car speed and spring tooth diameter, were chosen as the influence factors of the test-bed experiment. And collecting rate of residual film recycling was selected as the evaluation index of the test-bed experiment. Quadratic orthogonal rotation combination trial design was applied to build the quadratic polynomial regressive model, which interpreted the relationship between the experimental influence factors and evaluation index. Using the data analysis software of Design-Expert 8.0.6, the matching mathematical regression pattern was developed, the relation of salient factors with the evaluation index was analyzed, and the parameters of test were improved. The optimum combination of parameters could be reached when the number of spring teeth was 5, the diameter of spring tooth was 12 mm, and the speed of test car was 1.85 m/s. By using the soil bin trolley testing, the optimized results were verified on the basis of optimization parameters combination. The experimental consequences manifested that the collecting-film rate of the mechanism of monomer profiling raking-film was more than 88.5%, the optimization prediction model based on the quadratic multinomial fitting model was reliable, and the film recycling requirement could be met by the structure and working parameters combination. According to the standing cotton stalks standard field experiment in Changji, Xinjiang, the experimental cotton field was selected, which was pressed by the wheel of picking cotton locomotive and produced different fluctuation of pits and soil slope, and the results from the cotton field and the laboratory were basically consistent. The research provides an original theoretical reference for the design of raking film mechanism of single profiling, as well as the parameter optimization of remnant plastic film collector. [ABSTRACT FROM AUTHOR]

Objective: To explore the effect of long/chain fatty milk with different structure on the blood lipid levels, liver function, the influence of protein metabolism and the immune cell function of gastrointestinal tumor patient. Methods: 90 cases of the middle-late cancer patients were selected and randomly divided into the experimental group and control group respectively (n = 45). The patients were given nutrient solution with such as nitrogen and heat in the form of three bags with the "all-in-one" via deep vein infusion. The patients in experimental group were given 20%STG 250 mL and the patients in control group were given 20%MCT/LCT250mL, 5d for a period of treatment. ①The effects of fat emulsions on patients with liver function, blood lipids and clinical adverse reactions were observed. ② By monitoring the patients' concentration of serum total protein, albumin, prealbumin changes before and after the fat emulsion was given, two different kinds of fat emulsion effects on patients with protein metabolismand nitrogen balance were evaluated. ③ The peripheral blood in two groups of patients on the 1, 3 and 5 days after drug administration respectively and monitor immune function index changes in patients were collected. Results: ①The blood lipid levels of two groups of patients were significantly increased after Intravenous nutrition with 1 day (P < 0.05), but there was no significant difference between the two groups; the blood lipid levels in two groups of patients increased on 3th and 5th day after the infusion, the blood lipid levels in the experimental group increased more obviously than the control group (P < 0.05). ② The liver function index of patients in two groups were significantly increased on 1 day after being given the nutrition support (P < 0.01), but the liver function index of patients in the control group significantly rise faster than that in the experimental group, there was significant difference between two groups (P < 0.05). Among them, the TBil (total bilirubin) is still higher than that of preoperative in the control group on 3th and 5th day after nutritional support, and decreased slower; but that in the experimental group had fallen to normal, there was significant difference between the two groups.③the level of protein in the experiment group were significantly higher than that of control group, and the nitrogen balance in experiment group was significantly better than that of control group (P<0.05)④ the levels of CD3 +, CD4 +, CD4 + / CD8 + in the two groups were higher than that before the nutrition support (P<0.05) .The various immune function index in experiment group showed a significant rise on 1st, 3th and 5th day after intravenous infusion nutrition,which was significantly higher than that in control group, (P < 0.05). Conclusions: The structured lipid could significantly decrease the blood lipid level, reduce the liver function, effectively improve the nitrogen balance, stable the protein level, and promote the recovery of immune function compared to the physical structure of lipid emulsion mixed long/chain lipid. [ABSTRACT FROM AUTHOR]

The Gulf of Guinea in West Africa is dominated by swells, extreme waves are also characterized by this kind of wave, and it is different from that along the China coast for which extreme waves are induced by typhoon. When determining the design wave parameters for such sea areas that dominated by swells, study approaches for the typhoon waves are not suitable. In order to provide methods as reference for the calculation of nearshore extreme wave along swell-dominated coasts, two of the most used methods are summarized according to the wave study reports performed by DHI for ports in West Africa, and then finally the average of the calculated values from these two methods is recommended for designs. [ABSTRACT FROM AUTHOR]

Based on the Kribi Deep Sea Port project, a method of analysis on wave induced downtime is proposed, combining the ship mooring study, wave measurement data and wave propagating model. The results are compared and validated with that performed by foreign institutes. A method to analyze the influence of long period wave on the downtime is proposed and precautions in transformation from downtime to unavailable days are also pointed out. The method can be made reference for similar projects. [ABSTRACT FROM AUTHOR]

Aiming at falut diagnosis of EGR system during it’s working period, the characteristics of EGR valve drived by DC motor were researched, fault types of EGR system were summarized, including electric fault which includes H-Bridge short circuit to battery, short circuit to ground, short circuit overload error and open load error and functional fault which includes valve jammed error and zero drift. EGR valve zero position self-learning was carried out during functional diagnosis. The diagnostic and protection strategy was proposed and all kinds of diagnosis tests were carried out on a diesel engine. The results indicate that the diagnosis method can identify the various faults of EGR system in time. The corresponding protection strategy can work timely, which meets the demand of OBDII system application. [ABSTRACT FROM AUTHOR]

This paper discussed the non-monotonic problems and perturbations with commonsense reasoning, and established a structure of robotic commonsense reasoning based on improved active logic and metacognition loop (MCL). First, as to the problem that robots were prone to suffer from perturbations when executing missions, incorporated MCL to monitor perturbations and to guide robots. Second, improved active logic by defining three kinds of relationship between facts and commonsense, so called contained, negated, and irrelevant. Further, according to these definitions, this paper proposed the precondition and definition of contradicted knowledge and corresponding handling methods. What is more, it presented two kinds of attributions that the relationship of facts, namely that contained, had transitivity, and that the logic reasoning rules did not have direct transitivity. Facilitated by above improvements, active logic could deal with contradicted knowledge more efficiently. At the end, the experiment that the Pr2 robot gets a book validates the effects of the fact that MCL and improved active logic can help robots deal with perturbations and contradicted knowledge. [ABSTRACT FROM AUTHOR]

Nanomedicine requires the preparation of drug (gene) delivery vehicles with multiple response functions or targeting ability, for which new nanomaterials are constantly introduced. As an emerging class of crystalline porous materials, covalent organic frameworks (COFs) have the characteristics of high crystallinity, tunable pore size and easy modification of surface structure. The frame structure is completely determined by the building blocks and linkages, and the frame with the expected structure can be designed by reticular chemistry. The exposed active end groups on the surface of the structure could be functionalized through post-synthesis modification strategies, which expands the applicability of COFs in nanomedicine. This review briefly discusses the preparation strategies of COFs from the perspective of different linkages, and reviews the applications of COFs as antitumor agents and delivery vehicles in oncology medicine in detail. Finally, the existing problems of COFs in the field of tumor treatment and their future development directions are summarized and discussed. [ABSTRACT FROM AUTHOR]

Based on the Kribi Deep Sea Port project, a method of analysis on wave induced downtime is proposed, combining the ship mooring study, wave measurement data and wave propagating model. The results are compared and validated with that performed by foreign institutes. A method to analyze the influence of long period wave on the downtime is proposed and precautions in transformation from downtime to unavailable days are also pointed out. The method can be made reference for similar projects. [ABSTRACT FROM AUTHOR]

To assist conservationists make specific protection plans for the crested ibis (Nipponia nippon), promote the re⁃introduction success and increase its wild population size, we sampled 35 nest sites within 3 m×3 m quadrats to measure 22 habitat features from July to November during 2014-2019 in Dongzhai, Henan Province. Our results showed that the majority of nests were built in coniferous and broad-leaved mixed forests (n=23) and coniferous forests (n=10). At the early stage of rewilding, crested ibis had relatively diverse choices for nesting trees. At the later stage, however, they showed a clear preference for Pinus massoniana (n=27, 81. 8%) in the low Dabie Mountain. The average diameter at breast-height of the nesting trees was (35. 53±9. 82) cm, the average height was (16. 07±2. 27) m, and the average height of the nest from the ground was (12. 58±1. 70) m (n=33) . There were significant differences among diameters at breast height of the nesting trees, distance to the foraging sites from the nesting trees, distance to road, and the upper and lower canopy size at the nesting sites. Most nest sites were selected in the middle (n=18) or upper (n=11) positions of the trees. And nests adjacent to roads would interfere with the hatching success. Furthermore, distance to the foraging sites from the nesting trees had a significant impact on the survival rate of the young. This study further enhances the understanding of crested ibis nest site selection and provides certain reference significance for crested ibis conservation. [ABSTRACT FROM AUTHOR]

In this paper, the accuracy of the main indicators of the FHDI Global Normal Wave Model (FHDI-GNWM) is verified by selecting the observation data of 23 representative wave buoys in the oceans over the world. The results show that the verification results of wave heights calculated with model are good and meet the preset target. The correlation coefficient between the wave periods calculated with the model and the wave periods measured at the buoys is generally low, but the distribution characteristics are highly consistent. Compared with the accuracy test index parameters of wave mathematical models by internationally renowned bodies such as NOAA, OWI, ECMWF, BMT, and DHI based on buoy measured data, the results show that all the above global wave mathematical models have better wave height verification, but the wave periods tend to have low correlation coefficient and large dispersion, therefore, the verification of wave periods needs to combine Hs-Tp scatter plot, wave period rose diagram/frequency distribution figures, etc. to evaluate the overall distribution. [ABSTRACT FROM AUTHOR]

Aiming at rehabilitation training requirement for patients with ankle injury, a novel human ankle rehabilitation robot was designed based on 2-RURU/RR-type parallel mechanism. Firstly, motion output characteristic of the mechanism was analyzed and degree of freedom was computed by using the screw theory. The posture angular displacement and angular velocity equations were derived. The workspace of the mechanism was solved based on the numerical search method. Then, kinematic performances were analyzed by using the motion/force transmission index, and the performance distribution map of the mechanism was described. Optimal design of the mechanism was carried out based on the global transmission index. Finally, kinematics simulation was carried out based on ADAMS software, the physical prototype was built and rehabilitation test was performed as well. The results indicate that the rotation center of the designed ankle rehabilitation robot is adjustable, and it has uncoupled kinematic characteristics. After the optimization design, the ratio of the well transmission workspace of the mechanism is improved by 10.8%. The kinematic simulation and physical prototype experimental research show that the motion range of the rehabilitation robot can fully meet the rehabilitation training requirements of human ankle. The paper provides the key theoretical basis for the development of the parallel ankle rehabilitation robot. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect and mechanism of HBV 一 stimulated HTR8 一 S/Vneo mitochondrial antiviral signaling protein (MAVS) signaling pathway on the immune response of peripheral blood mononuclear cell (PBMC) to hepatitis B vaccine. Methods The HTR8 - S/Vneo were co 一 incubated with serum of HBV - DNA positive patients. MAVS siRNA transfection was hereby applied for silencing of MAVS and MAVS plasmid transfection was applied for overexpression of MAVS in HTR8 一 S/Vneo. We then cocultured them with human immune cells assembly PBMC and subsequently stimulated with hepatitis B vaccine. The mRNA and protein expression levels of MAVS, NF - kB, pNF - kB, IRF3 and pIRF3 in HTR8 一 S/Vneo were detected by reverse transcription 一 quantitative real 一 time PCR (RT 一 qPCR) and flow cytometry (FCM). The levels of IL - 2, IL - 6, IFN 一 p and IL 一 17 were detected by enzyme - linked immunosorbent assay (ELISA), and the proportion of CD4+ T cell were detected by flow cytometry. The data were analyzed for t test. Results HBV down 一 regulated the mRNA expression levels of MAVS, NF - kB, IRF3 (£ 二 6. 66, P 二 0. 003; £ 二 14. 18, P < 0. 001; £ 二 3. 70, P 二 0. 021) and the protein expression levels of MAVS, NF - kB, pNF - kB(£ 二 3. 42, P = 0. 042; £ 二 4. 23, P = 0. 013; £ 二 4. 86, P - 0. 008), and inhibited the production of IFN - p(£ 二 9. 83, P = 0. 010). Silencing MAVS down 一 regulated the mRNA and protein expression of MAVS(£ 二 31. 20, P < 0. 001; £ 二 6. 53, P = 0. 023), inhibited the expression of IFN - p(£ 二 5. 46, P =0. 032), and reduced the proportion of CD4+ T cells in PBMC(£ 二 9. 07, P = 0. 001). Overexpression of MAVS induced IFN 一 B production(£ 二一 34. 26, P < 0. 001; t - -5. 11, P = 0, 036), but the proportion of CD4 * T cells did not show significant effect (/二 一 0. 73, P 二 0. 506). Conclusion HBV can inhibit the MAVS signaling pathway in HTR8 一 S/Vneo. Overexpression of MAVS could promote the immune response to hepatitis B vaccine in PBMC. [ABSTRACT FROM AUTHOR]

We studied the unique kinematic properties in massive filament G352.63-1.07 at 103 au spatial scale with the dense molecular tracers observed with the Atacama Large Millimeter/submillimeter Array. We find the central massive core M1 (12 M ⊙) being separated from the surrounding filament with a velocity difference of v − v ¯ sys = − 2 km s − 1 and a transverse separation within 3″. Meanwhile, as shown in multiple dense-gas tracers, M1 has a spatial extension closely aligned with the main filament and is connected to the filament toward both its ends. M1 thus represents a very beginning state for a massive, young star-forming core escaping from the parental filament, within a timescale of ∼4000 yr. Based on its kinetic energy (3.5 × 1044 erg), the core escape is unlikely solely due to the original filament motion or magnetic field but requires more energetic events such as a rapid intense anisotropic collapse. The released energy also seems to noticeably increase the environmental turbulence. This may help the filament to become stabilized again. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of different proportions of enteral combined with parenteral nutrition treatment on patients with severe traumatic brain injury (s TBI). Methods: The subjects of study were s TBI patients admitted to the Neurointensive Care Unit of Chongqing Emergency Medical Center from October 2020 to August 2022. 70 patients who met the inclusion and exclusion criteria were randomly divided into the experimental group and the control group with 35 cases each. Calculate the daily caloric requirements of patients and provide nutritional support according to different proportion of enteral and parenteral nutrition programs. The experimental group was given enteral and parenteral nutrition support at a ratio of 2:1, while the control group was given enteral and parenteral nutrition support at a ratio of 1:1. The differences of nutritional status indicators (hemoglobin, albumin, prealbumin, total protein), immune function indicators [CD3, CD4, CD4/CD8, immunoglobulin (Ig)A, Ig M, Ig G], inflammatory indicators [C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6)] and complications between the two groups were statistically compared. Results: In terms of immune function, the levels of CD4, CD4/CD8 and Ig A in the experimental group were significantly higher than those in the control group 14 d after nutritional support (P＜0. 05); There was no significant difference between the two groups in nutritional status, inflammatory indicators and complications (P＞0. 05). Conclusions: Enteral nutrition-based combined nutritional support can promote the recovery of immune function in patients with s TBI, but there is no significant difference in nutritional status, inflammatory indicators and complications between different proportions of enteral combined parenteral nutrition treatment. [ABSTRACT FROM AUTHOR]

To solve the problem that the classification of pedestrian attributes was affected by the imbalanced pedestrian attributes, a pedestrian attribute classification was proposed based on label sensitive convolutional neural network(CNN). The existing convolutional neural network structure was adjusted. By integrating the positive and negative channel activation modules, the model could perceive more detailed pedestrian attributes. The attribute imbalance loss function was introduced, and the network weights were adaptively updated according to the imbalance ratio of attributes. The back propagation of error was used to increase the weight of small-class attributes, and the sensitivity of model to the small-class attributes was improved. 54 attributes were classified on the PETA data set. The results show that compared with MLCNN and other methods, the new method is improved for 36 classification tasks. The average accuracy, the average recall and the average AUC are increased by 2.13%, 2.38% and 1.19%, respectively. [ABSTRACT FROM AUTHOR]

Achieving AlGaN epitaxial layer with high Al content and excellent electrical properties is one of the most important aspects in the preparation of deep ultraviolet optoelectronic devices. In this work, a series of Si-Al x Ga1 - x N epitaxial layers with high Al content (x > 0. 60) were obtained on AlN/ sapphire substrates using molecular beam epitaxy (MBE) system, based on the growth method of periodic thermal desorption. Al content was modulated by changing the size of Al source supply, and n-type doping was realized with Si. The physical properties of the epitaxial layers were characterized. The results show that: Al content of the epitaxial layers shows a linear relationship with the Al flux size, which lays the foundation for the growth of AlGaN epitaxial layers with precise content. The AFM measurements reflect that the surface morphology of the AlGaN epitaxial layers strongly depend on the Ga supply. The electrical properties of Si-AlGaN epitaxial layers were measured based on the Vanderbilt method, and the good performance was confirmed. The free electron concentration, electron mobility and resistivity of the sample with Al content of 0. 93 reach 8. 9 × 10 18 cm - 3, 3. 8 cm 2 ·V - 1 ·s - 1 and 0. 18 Ω·cm respectively at room temperature. [ABSTRACT FROM AUTHOR]

In this paper, conventional continuous epitaxial growth and metal modulated epitaxial (MME) growth of AlN were investigated with the plasma-assisted molecular beam epitaxy (PA-MBE) system. It is difficult to control the growth mode of the conventional continuous epitaxial growth method, in which excessive Al-rich and N-rich growth modes easily occur, and also a slightly Al-rich growth mode is accompanied by the appearance of some pits, leading to rough surface morphology. However, the growth mode of AlN films is easier to control by MME method, by which AlN films with good morphology can be fabricated by adjusting the supply time of Al and N sources. The optimized MME solution is proposed as follows: firstly, opening the Al source shutter for 30 s, then opening the Al and N source shutters for 60 s, and finally opening the N source shutter alone for 72 s, the ratio of Al source shutter opening time to N source shutter opening time of a single cycle is 0. 7. Almost pits-free AlN films with a low roughness of 0. 3 nm (2 μm × 2 μm) are fabricated after 40 cycles. [ABSTRACT FROM AUTHOR]

A numerical wave model is used to make a preliminary statistical analysis of the distribution characteristics of sea waves in the coastal sea areas based on the FHDI-GNWM hindcast wave data from 2015 to 2019 and preliminary conclusions were drawn as following: 1) the wave direction in the study sea area is basically consistent with the wind direction and the main wave direction in winter is E direction while the main wave direction in summer is SSW direction; and 2) the waves in the study sea area are mainly wind waves and characterized obviously by monson waves with smaller wave heights in summer with an average wave height between 0:4 m and 0.7 m and bigger wave heights in winter with an average wave height between 0.85 m and 1.1 m. Furthermore, the wave-induced downtime related to ship loading and unloading is also analyzed for a container terminal based on ship mooring testing. The results of the study provide reference for the knowledge of the characteristics of waves and winds in the coastal sea areas and for the designs of similar port projects. [ABSTRACT FROM AUTHOR]

The micro-grid is an important part of future Smart Distribution Automation, and the micro-grid technology is a trend of the future distributed power system. Combined with the current hot issue in the field of power system, i.e. , micro-grid stability problem, an experiment course of "stability analysis experiment of micro-grid based on small-signal model" is proposed for the students of electrical engineering and related majors, The course includes theoretical knowledge of MATLAB/Simulink, theoretical knowledge of DC micro-grid and stability analysis, small signal modeling of converter and stability analysis of cascade converters. It also contains choosing topics and the corresponding MATLAB simulation, seminars and so on. Students are required to master the simple DC micro-grid small signal stability analysis within 20 courses. This experiment course focuses on the issues concerned at present and nearly future, combines the control theory analysis with new energy power grid, makes students understand the new development of science and technology and the academic trends, enlightens students’ thought of scientific research, and introduces the research method (small signal analysis) to the experiment teaching activities. [ABSTRACT FROM AUTHOR]

Objective Dyslipidemia has shown to be associated with cardiovascular, metabolic and renal diseases. This study aimed to investigate the association between residual cholesterol and the risk of subclinical renal damage (SRD). Methods A total of 2 342 participants were recruited from the previously established Hanzhong Adolescent Hypertension Study cohort. According to estimated glomerular filtration rate(eGFR) and urinary albumin-to-creatine ratio(uACR), the subjects were divided into SRD group and non-SRD group. The associations of residual cholesterol with eGFR, uACR, and the risk of SRD were analyzed by multiple linear and Logistic regression analyses. Results Residual cholesterol was positively correlated with uACR(r=0.081, P<0.001) but negatively correlated with eGFR (r=-0.091, P<0.001). Multiple linear regression analysis revealed that residual cholesterol was an influencing factor of uACR (β=0.075, P<0.001) and eGFR (β=-0.027, P<0.001) after adjustment for gender, age, smoke, alcohol, exercise, BMI, hypertension, diabetes and serum uric acid. In addition, Logistic regression analysis revealed that residual cholesterol was significantly associated with the risk of SRD independently of potential confounders [OR(95% CI)=1.387 (1.113-1.728), P<0.001]. Further subgroup analysis showed that residual cholesterol was significantly associated with the risk of SRD in women but not in men. Conclusion Residual cholesterol is a contributing factor in the risk of subclinical renal damage with gender-specific association. [ABSTRACT FROM AUTHOR]

Objective Based on our previously established salt-sensitive hypertension cohort, we aimed to examine the association of genetic variants in uromodulin with blood pressure(BP) responses to dietary interventions of sodium and potassium intake. Methods In 2004, 514 subjects from 124 families in Mei County, Shaanxi Province, were recruited to establish the salt-sensitive hypertension study cohort. Among them, 333 non-parent subjects were selected and sequentially maintained on a normal-diet for 3 days, low-salt diet for 7 days, then a high-salt diet for 7 days and a high-salt diet with potassium supplementation for another 7 days. Thirteen single nucleotide polymorphisms(SNPs) in the uromodulin gene were genotyped on the MassARRAY platform. Results BP levels decreased from the baseline to low-salt diet, increased from low-salt to high-salt diet, and decreased again from the high-salt diet to the high-salt plus potassium supplementation intervention. SNPs rs77875418 and rs4997081 of the uromodulin gene were significantly associated with diastolic BP(DBP) and mean arterial pressure(MAP) responses to high-salt diet. In addition, SNPs rs77875418, rs79245268, rs4293393, rs6497476, rs4997081, rs13333226, and rs12917707 were significantly associated with systolic BP(SBP), DBP, and MAP responses to high-salt diet with potassium supplementation. Conclusion Genetic variants in uromodulin gene are significantly associated with BP responses to sodium and potassium supplementation, suggesting that uromodulin may be mechanistically involved in BP sodium-sensitivity and potassium-sensitivity. [ABSTRACT FROM AUTHOR]

Objective 4-like protein with down-regulated expression and development in neural precursor cells (NEDD4L) plays an important role in blood pressure (BP) regulation and sodium homeostasis by regulating epithelial sodium channel protein. In this study, we aimed to explore the relationship of NEDD4L gene polymorphisms with BP responses to sodium and potassium intake. Methods In 2004, 514 subjects from 124 families in Meixian County, Shaanxi Province, were recruited to establish a salt-sensitive hypertension study cohort. All the subjects received a 3-day baseline survey, a 7-day low-salt diet, a 7-day high-salt diet, and finally a 7-day high-salt and potassium supplementation. Their BP was measured and peripheral blood samples were collected at different intervention periods. The 14 gene polymorphisms of NEDD4L gene were genotyped and analyzed by MassARRAY platform. Results BP decreased on a low-salt diet, and significantly increased on a high-salt diet, and decreased again after potassium supplementation. NEDD4L SNPs rs74408486 were significantly associated with systolic BP, diastolic BP and mean arterial pressure responses to the low-salt diet. SNPs rs292449 and rs2288775 were significantly associated with pulse pressure response to the high-salt diet. In addition, SNPs rs563283 and rs292449 were significantly associated with diastolic BP, mean arterial pressure, and pulse pressure responses to high-salt and potassium supplementation diet. Conclusion NEDD4L gene polymorphisms were significantly associated with BP responses to sodium and potassium intake, suggesting that NEDD4L gene may be involved in the development of salt sensitivity and potassium sensitivity. [ABSTRACT FROM AUTHOR]

Objective M3 muscarinic acetylcholine receptor(M3 receptor), encoded by CHRM3 gene, is widely distributed in the cardiovascular system and plays an important role in cardiac regulation. The aim of this study was to assess the association of genetic variants in M3 receptor with blood pressure(BP) responses to controlleddietary sodium and potassium interventions. Methods A total of 333 subjects from 124 families were recruited from the rural areas of northern China. After a three-day baseline observation, they were sequentially on a seven-day low-salt diet, a seven-day high-salt diet, and a seven-day high-salt diet plus potassium supplementation. Thirteen CHRM3 single nucleotide polymorphisms(SNPs) were selected for analysis. Results SNP rs10802811 of the CHRM3 was significantly associated with diastolic BP(DBP) and mean arterial pressure(MAP) responses to both low-salt and high-salt diets while SNPs rs6429147, rs373288072, rs114677844 and rs663148 showed significant associations with systolic BP(SBP) and MAP responses to high-salt diet. In addition, SNP rs6692904 was significantly associated with SBP, DBP and MAP responses to high-salt diet with potassium supplementation. Conclusion Genetic variants in M3 receptor are significantly associated with BP responses to sodium and potassium intervention, suggesting that M3 receptor may be mechanistically involved in BP salt and potassium sensitivity. [ABSTRACT FROM AUTHOR]

Objective Corin, a transmembrane serine protease that can cleave atrial natriuretic peptide precursor (pro-ANP) into atrial natriuretic peptide with smaller bioactive molecules, participates in the pathophysiologicalprocess of hypertension and cardiac hypertrophy. The purpose of this study was to explore the relationship of Corin gene variation with blood pressure responses to sodium and potassium dietary interventions. Methods In 2004, we recruited 514 participants from 124 families in 7 villages of Baoji, Shaanxi Province, China. All the subjects received a 3-day normal diet, a 7-day low-salt diet, a 7-day high-salt diet, and finally a 7-day high-salt and potassium supplementation. Fifteen single nucleotide polymorphisms (SNPs) of Corin gene were selected for final analysis. Results SNPs rs12509275 were significantly associated with diastolic blood pressure (DBP) response to low-salt diet, while rs3749584 was associated with pulse pressure (PP) response to low-salt diet.SNP rs3749584 and rs10517195 were significantly associated with PP response to high-salt diet. In addition,rs17654278 were significantly associated with systolic blood pressure (SBP) response to high-salt and potassium supplementation, rs2271037 was significantly correlated with DBP responses to high-salt and potassium supplementation, and rs4695253, rs12509275, rs2351783, rs36090894 were significantly associated with PP response to high-salt and potassium supplementation. Conclusion Corin gene polymorphisms were associated with blood pressure response to sodium and potassium, suggesting that Corin gene may be involved in pathophysiological process of salt sensitivity and potassium sensitivity. [ABSTRACT FROM AUTHOR]

With the progress of era, the training of qualified innovative talents does not only rely solely on teaching laboratory resources. This article introduced guidance and methods of the experimental platform based on the spirit of national experimental teaching demonstration center of "The 12th Five Year Plan". Professional quality training platform, research quality training platform, engineering quality training platform and innovative practice platform are built up to train students' ability by fully using advantage resources of professional and industry. These platforms form an experimental teaching environment which has prominent professional features, quality sharing resource, teaching and research collaboration, combination of university and enterprise. It offers a broad platform for students to improve their practice ability and research ability, promote their knowledge, ability, quality and coordinated development. [ABSTRACT FROM AUTHOR]

Objective To intervene chronic salt load and potassium supplementation in the previously established "Salt Sensitive Hypertension Research Cohort", aiming to explore the population's renal aminase The relationship between genetic polymorphism and blood pressure sodium and potassium responsiveness. Methods In 2004, 514 subjects from 126 families were recruited in Meixian, Shaanxi Province to establish Perceptual Hypertension Study Cohort", among them, 334 non-parents were tested for chronic salt load and potassium supplementation intervention, including 3d normal diet-7d low-salt diet -7d high-salt diet -7d high-salt potassium diet. The MassARRAY detection platform was used to type and detect 10 polymorphic loci of the reninase gene. Results The reninase gene polymorphism site rs2576178 was correlated with systolic blood pressure and mean arterial pressure responsiveness during low salt period (systolic blood pressure: β=-2.730, P=0.005; mean arterial pressure: β= -1.718, P=0.028). In addition, the rs17109290 locus is correlated with the diastolic blood pressure response during the low-salt period (β= -1.608, P=0.031). This study did not observe the correlation between these polymorphic sites and blood pressure potassium responsiveness. Conclusion The genetic polymorphism of reninase gene is associated with The responsiveness of blood pressure during the low salt period is closely related, suggesting that the reninase gene may be involved in the formation of blood pressure salt sensitivity. [ABSTRACT FROM AUTHOR]

Class-imbalanced data refers to the large difference in the number of samples in different classes.AUC is an important metric to measure the performance of classifiers on the imbalanced datasets.Since AUC is not differentiable,researchers have proposed many surrogate pairwise loss functions to optimize AUC.The number of pairwise losses is the product of the number of positive and negative samples.Many positive and negative pairs with small pair loss affect the performance of classifiers.To solve this problem,this paper proposed a weighted pairwise loss function WPLoss.By assigning higher loss weights to the positive and negative samples with higher pairwise losses,WPLoss reduced the impact of positive and negative sample pairs with smaller pairwise losses.The experimental results on 20 newsgroup and Reuters-21578 datasets verify the validity of WPLoss,indicating that WPLoss can improve the performance of the classifier for class-imbalanced data. [ABSTRACT FROM AUTHOR]

In order to solve the problem of strong motion coupling caused by structural coupling of parallel mechanisms, a novel 2-CPR/RRR planar translational parallel mechanism with one pure constrained kinematic chain was proposed. Based on the screw theory, the degree of freedom and output motion characteristics of the mechanism were analyzed. The position vector equations were established in terms of the geometric conditions of the mechanism, and the kinematic mathematical mode were derived under the different input forms, rotary or linear. Kinematic simulation was performed by using Admas and Matlab, the kinematical curves of displacement, speed and acceleration were described. Finally, a new hybrid 3 D printer was designed based on the parallel mechanism proposed. The experimental results show that when the rotary displacements of the cylindrical pair is selected as the actuated inputs, the Jacobian matrix is a diagonal one and the mechanism has the uncoupled kinematics. Especially, while the linear displacements of the pair is as the inputs, the Jacobian becomes an unit matrix and it shows fully-isotropic throughout its whole workspace. [ABSTRACT FROM AUTHOR]

This paper proposed the concept of weighted mean face to deal with the problem of pose varied face recognition.Firstly, according to face vacillating change, this paper defined the calculation method of the weight of each pose varied face, and then proposed the construction method of weighted mean face. Then, based on the pitch angles of pose varied faces, it divided the pose varied faces into three levels: upward view, parallel view and downward view. In each view level, constructing weighted mean face, thus it formed a weighted mean face matrix. Finally, this paper used the improved locality preserving projection method to extract deep feature of weighted mean face matrix and realized pose varied face recognition. The experiments show that the proposed approach can effectively extract the key information of pose varied faces and improve recognition effect greatly. [ABSTRACT FROM AUTHOR]

In order to distinguish the perception and controller of end-to-end automatic steering models, this paper improved the structure of the deep learning network. By pre-training an autoencoder and gelling a good road feature alter encoding, it used the encoder as a perception and trained with the steering wheel angle prediction controller model by end-to-end approach. The training results show that the improved automatic steering network model converges faster, and the predicted angle can change well with the change of the actual angle. By using the decoder and the feature map reverse propagation method respec­tively , this paper restored the road pictures and visualized the road characteristics that the automatic steering model focused on. [ABSTRACT FROM AUTHOR]

Objective To investigate the expression of the long non - coding RNA (IncRNA) XLOC -007123 in cancer and adjacent tissue, as well as hepatoma cell lines, in patients with hepatitis B - related hepatocellular carcinoma ( HCC) , and the association between its expression level and clinicopathological features. Methods A total of 52 patients with hepatitis B - related HCC who underwent resection of HCC in Center of Hepatobiliary Surgery , 302 Hospital of PLA. from December 2013 to December 2015 were enrolled, and HCC tissue samples were collected. Adjacent tissue samples collected from the same patient were used as controls. Quantitative real - time PCR was used to measure the expression of the; IncRNA XLOC -007123 in HCC tissue, adjacent tissue, and hepatoma cell lines in the patients with hepatitis B - related HCC. Normal liver cell line L02 and hepatoma cell lines HuH7 , HepG2 . and SMMC - 7721 were obtained from Research Center for Clinical and Translational Medicine, 302 Hospital of PLA. The nonparametrie Wilcoxon rank sum test was used to compared the expression of the IncRNA XLOC -007123 between HCC tissue and adjacent tissue, and the independent samples t - test was used to compare the expression of the IncRNA XLOC -007123 between HCC cell lines and the normal liver cell line;. The chi - square test was used for comparison of clinical indices. Results In the patients with hepatitis B - related HCC. the expression of the IncRNA XLOC -007123 was significantly lower in HCC tissue than in adjacent tissue (P <0. 01 ) also, the expression of the; IncRNA XLOC -007123 was significantly lower in HuH7. HepG2, and SMMC -7721 cells than in L02 cells (all P<0.05). The; expression of the IncRNA XLOC -007123 was associated with the serum level of alpha - fetoprotein ( AFP) and tumor stage (X<2 =7.738 and 7. 589 , both P <0. 05 ). Conclusion There is a reduction in the expression of the IncRNA XLOC -007123 in hepatitis B - related HCC tissue, which is associated with the serum level of AFP and pathological staging, suggesting that the IncRNA XLOC -007123 may exert a regulatory effect in the development and progression of hepatitis B - related HCC and may become a potential marker for the diagnosis of hepatitis B - related HCC. [ABSTRACT FROM AUTHOR]

To research the seismic behavior of concrete filled T-section steel tube columns and steel beam frames, two specimens were tested by quasi-static test. The influence of axial compression ratio on the frame hysteretic behavior was discussed. The experimental results show that the beam-hinge failure mechanism is realized. With the increase of horizontal load, the hysteretic curves of frames become fuller and fuller. The displacement ductility coefficients in two loading directions are above 4.0, which satisfies the seismic design requirement of building structure. Axial compression ratio is the major factor that affects frame seismic behavior. The higher the axial compression ratio is, the greater the energy dissipation capacity is, but the displacement ductility of the frame is reduced. A simple tri-linear restoring force model was proposed, which could provide the reference for the application of the concrete filled T-section steel tube columns and steel beam frame in engineering. [ABSTRACT FROM AUTHOR]

In order to avoid the singular problem of within-class separation degree matrix caused by small sample problem in supervised kernel locality preserving projection algorithm,this paper proposed a novel supervised locality preserving projection method based on the maximum separation degree difference. It first presented the concept of within-class separation degree and between-class separation degree, then constructed the discriminant criterion of differential mode based on within-class separation degree matrix and between-class separation degree matrix. It extended the algorithm to the nonlinear case,and proposed the supervised kernel locality preserving projection based on maximum separation degree. Finally, experimental results on Yale, ORL and CAS-PEAL-R1-P0SE face databases show that the proposed method is effective. [ABSTRACT FROM AUTHOR]