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The marine-terrestrial interlaced zone serves as a crucial spatial hub linking the functional zoning of both land and sea areas. Optimizing the ecological function, economic function, and national security function of the marine-terrestrial interlaced zone is of significant importance for promoting the coordination between land and sea functional oriented zoning and achieving their mutual beneficial interaction. It also contributes to enhancing the economic, social, and environmental benefits, effectively allocating resources, and advancing social sustainability. Building upon the clarification of the current development status and characteristics of China's marine-terrestrial interlaced zone, the research systematically examines the key issues existing in the coordination between land and sea functional oriented zoning at the marine-terrestrial interlaced zone. Furthermore, it puts forward key construction tasks and development pathways aimed at enhancing the coordination functions of the marine-terrestrial interlaced zone. [ABSTRACT FROM AUTHOR]

The structure characteristic of polyvinylidene fluoride membrane and graphene oxide was main introduced, respectively, and the advantages of organic-inorganic hybrid membrane were analyzed. The preparation method of GO/PVDF membrane were stated in detail, including solution casting method, electrospinning method, chemical grafting method, vacuum filtration method and so on. Based on the recent research status, the advantages and disadvantages of the above methods were analyzed. Then, the effects of GO on pore size, hydrophilicity and hydrophobicity, membrane flux, rejection, and mechanical properties of membrane were expounded. And the applications of GO/PVDF membrane in water treatment and other potential applications were reviewed. It was found that the solution casting method was simple and short, and the membrane produced by the chemical grafting method had a stable bond between each component and a long service time, while the membrane produced by the electrostatic spinning method had a large specific surface area and high porosity. The capillary action of the GO lamellar capillarity occurred, and the smaller particles would pass through the GO lamellar at a faster speed, the membrane flux was improved in macroscopic view. GO also improved surface finish, reduced the impurities blockage and pollution, and then improving service life of GO/PVDF membrane. The research direction and development trend of GO/PVDF membrane was prospected, thus would provide theoretical basis and technical support for the construction of efficient and stable PVDF separation membrane. [ABSTRACT FROM AUTHOR]

C5F10O has been put into practical application as a new environmental protection insulating gas that can replace SF6. Partial discharge and other faults will inevitably occur in the insulation equipment, resulting in the decomposition of C5F10O to produce harmful components such as weak insulation CF4, C2F6 and highly toxic CF2O, HF, etc. In order to ensure the safe operation of insulation equipment, these decomposition components need to be selectively removed by adsorption. The new graphene-like C3N material has a good application prospect in the field of gas detection. In this paper, the adsorption process of CuO-C3N on the main decomposition components CF4, C2F6 and highly toxic products CF2O and HF is calculated based on the first-principle. The adsorption energy, density of states, charge transfer amount, differential charge density and recovery time at different ambient temperatures are calculated and analyzed. The results show that CuO-C3N has good adsorption for HF, followed by CF2O, but it can not adsorb CF4 and C2F6. Therefore, CuO-C3N can be used as a high-performance gas adsorbent to remove the highly toxic HF gas in C5F10O insulation equipment. [ABSTRACT FROM AUTHOR]

[Objective] The present paper aimed to explore the photosynthesis-related cold-resistant genes in Mandragora chinghaiensis grown at high altitude and low temperature. [Method] Taking 0 °C low temperature stress Qinghai eggplant ginseng as the experimental material, the key time points were found through photosynthetic physiological experiments, and then transcriptomics analysis was carried out to screen photosynthetic related cold-resistant genes and perform real-time fluorescence quantitative analysis. [Result] The net photosynthetic rate, stomatal conductance, transpiration rate, maximum fluorescence, maximum photochemical efficiency of photosystem II, photochemical quenching coefficient, and electron transfer rate showed a gradual downward trend, while the intercellular CO2 concentration, initial fluorescence, and non-photochemical quenching coefficient showed an upward trend. Based on the comprehensive analysis of changes in photosynthetic and chlorophyll fluorescence parameters, the key time node was 12 hours. According to the analysis of transcriptome, seven genes were screened. Through qRT-PCR analysis, the expression of CP43 gene was up-regulated first and then down-regulated, showing an overall upward trend; The expression of CAB-8, САВ-11, СР24-10B, CH-02, FD-C2, and PSI-D2 genes was first down-regulated and then up-regulated, showing an overall downward trend. [Conclusion] The results of the study provided some theoretical support for the screening of photosynthesis-related cold resistance genes and the subsequent transgenic verification, the main purpose of screening genes has been achieved. [ABSTRACT FROM AUTHOR]

CF3I,as the most potential new environmental protection insulating gas of SF6,will produce C2F6,C2F4 and other strong greenhouse gases in cases of partial discharge, overheating and other defects in electrical equipment.In order to ensure the stable operation of power equipment, it is necessary to adsorb and remove the typical decomposition components of CF3I.In this paper, based on the first principle calculation method of density functional theory, the adsorption properties of C2F6 and C2F4 gas molecules by different amounts of Pt doped MoSe2 were investigated through adsorption indexes such as adsorption energy, adsorption distance, charge transfer and density of states. The results show that there are stable doping structures on the surface of MoSe2 doped with different amounts of Pt, and the conductivity of MoSe2 doped with Pt is effectively enhanced compared with that of intrinsic MoSe2. The adsorption effects of Pt doped MoSe2 on the decomposed components of CF3I are: Pt2-MoSe2>Pt-MoSe2>Pt3-MoSe2>Pt4-MoSe2. Pt2-MoSe2 shows strong chemical adsorption on C2F4 and weak physical adsorption on C2F6. Pt2-MoSe2 has selective adsorption to the decomposition components of CF3I, and hence is expected to be used as the adsorption and removal material of C2F4, a typical decomposition component of CF3I. [ABSTRACT FROM AUTHOR]

The phenomenon of urban growth and shrinkage coexist in China's rapid urbanization process, and urban shrinkage in the old industrial bases is a long-time disturbing problem. Based on the population and economic changes in cities of China's old industrial bases from 2009 to 2018, this paper analyzed the status and types of urban shrinkage and explored its influence mechanism. Results show that: (1) In general, the type of urban shrinkage of the old industrial base cities are mainly economic shrinkage, the type of population-economic shrinkage comes second, and pure population shrinkage is relatively few. The economic shrinkage and population-economic shrinkage cities mostly show the continuous spatial distribution, the population shrinkage type show the "dot" distribution features. (2) The shrinkage path goes as that economic decline precedes population loss in most old industrial base cities, and in few old industrial base cities, population loss led to economic decline. The cities in line with the former transformation path are mainly in central provinces and northeastern regions of China, while the cities in line with the latter transformation path are mainly in the northeast old industrial base. (3) The analysis of the influencing factors of old industrial base cities shows that birth rate, employment structure, industrial structure, opening-up policy, investment in science and technology affect the growth and shrinkage of urban population and economy in different directions and degrees. [ABSTRACT FROM AUTHOR]

人多能干细胞来源间充质干细胞 （hPSCs-MSCs） 具有与成体间充质干细胞 （MSCs） 相 似的分化功能, 还具有体外增殖能力强、来源丰富和免疫原性风险低等优点。hPSCs-MSCs 可应用于 免疫调节、抑制炎症、血管化和组织缺损修复及再生等多个领域, 使其成为在再生医学和组织工程中 应用最多的种子细胞。针对现有问题并结合相关文献, 对 hPSCs-MSCs 的分化、鉴定标准、纯化方法 和细胞性能等进行综述, 为 hPSCs-MSCs 在再生医学与组织工程领域中的应用研究提供理论依据。 [ABSTRACT FROM AUTHOR]

g3（green gas for gird） environmental protection gas（C4F7N/CO2 mixture）, as the most potential new environmentally friendly insulating substitute gas for SF6, has received extensive attention in recent years. Defects such as partial discharge and overheating are detected by analyzing the decomposed components in the g3 gas-insulated combined switchgear, which plays an important role in the evaluation and diagnosis of the operation status of power equipment. In this paper, the modification of Si atoms is proposed to improve the gas sensing and adsorption properties of MoS2. Based on the calculation method of density functional theory（DFT）, the intrinsic properties of MoS2 are explored through parameters such as adsorption energy, charge transfer, density of states and local density of states. The adsorption gas-sensing mechanisms of MoS2 and Si-MoS2 to the typical decomposition components of g3 gas—COF2, CF4, CF3CN. The analysis shows that Si atoms have a stable doping structure on the surface of MoS2. Compared with the intrinsic MoS2, the conductivity of MoS2 modified by Si atoms has been effectively enhanced; Si-MoS2 exhibits strong chemical adsorption to COF2 and CF4 gases, it is weak physical adsorption to CF3CN, the adsorption strength is CF4＞COF2＞CF3CN, and in the adsorption process Si-MoS2 always acts as an electron donor, transferring electrons to gas molecules; Si-modified MoS2 has selective adsorption to g3 gas decomposition components. It provides a theoretical basis for the development of MoS2 high-performance gas sensors for detecting CF4 and COF2 gases. The research results are also of great significance in reducing greenhouse gas emissions and improving the operational stability of GIS（Gas Insulated Switchgear). [ABSTRACT FROM AUTHOR]

Objective Optimize the latex perfusion technique and apply it to the construction of a murine craniofacial venous vascular model. Methods A total of nine 8-week-old male C57BL/6 mice weighing (25.0±1.3) g were randomly divided into three groups: 60% latex physiological saline group, 60% latex heparin group, and 30% latex heparin group. After completion of the perfusion, the specimens were immersed in 4° C formalin fixative for 24 h, followed by dissection, observation, and measurement of the extracranial blood vessel diameters. Results After 200 µL latex perfusion solution was injected into the external jugular vein, the supraorbital vein, infraorbital vein, temporal vein, retrofacial vein, masseter vein and external jugular vein were perfused in each group. After comparing the perfusion degree of the distal branches of blood vessels, sublingual vein and tip venule, it was found that the 30% latex heparin group had the best perfusion effect, followed by the 60% latex heparin group, and the 60% latex saline group had the worst perfusion effect. Conclusion The optimized latex perfusion technique can effectively infuse the veins in the head and face of mice, and this technique can provide a good reference for the study of the direction and morphology of facial veins in mice. [ABSTRACT FROM AUTHOR]

Accurate prediction of gas reservoir productivity is directly related to the effective formulation of development plans. Geophysical logging can directly obtain reservoir information from the wellbore, and effectively characterize the parameters related to productivity, such as porosity, permeability, and oil saturation, so the industry pays much attention to the research on logging prediction of gas reservoir productivity. After systematically investigating the literature reports on gas reservoir productivity prediction methods at home and abroad, the main controlling factors were briefly described that affect the gas reservoir productivity, and four common reservoir productivity logging prediction methods were summarized, such as logging curve feature method, mathematical statistics method, gas production index method, artificial intelligence method. Finally, the applicability of gas reservoir productivity logging prediction methods was analyzed, and the future gas reservoir productivity logging prediction methods were prospected. Providing a certain theoretical reference for the future optimization of various gas field productivity prediction methods. [ABSTRACT FROM AUTHOR]

行心脏手术治疗的患者大多心功能较差, 对麻醉的耐受性低, 因此在手术过程中合理选择麻醉药物对心 脏疾病患者术中维持血流动力学稳定、减少应激至关重要. 瑞马唑仑是-种新型镇静药物, 麻醉诱导具有起效迅 速、恢复快、血流动力学稳定及呼吸抑制轻微等优点, 已先后批准用于程序性镇静及全身麻醉. 目前, 瑞马唑仑在心 脏手术患者全身麻醉中应用的相关研究较少且样本量较小, 但其在心脏瓣膜置换术、冠状动脉旁路移植术、经皮二 尖瓣钳夹术等心脏手术中被发现可维持患者术中循环稳定性且不良反应较少. 瑞马唑仑具有较高有效性及较好安 全性, 有望成为行心脏手术治疗患者全身麻醉的候选镇静新药. [ABSTRACT FROM AUTHOR]

BACKGROUND: Vascular transplantation is a hot research topic in vascular surgery at present. However, the detection of mechanical properties of preserved vascular wall needs to be solved urgently. OBJECTIVE: To summarize the techniques used by researchers to study arterial wall mechanics and the problems faced in this research direction. METHODS: The first author searched CNKI, WanFang, PubMed, and Google Scholar databases for relevant literature published from 2016 to 2022. The Chinese search terms were “aortic blood vessel, arterial wall, mechanics, elasticity, detection method” and the English search terms were “aortic vessels, arterial walls, mechanical model, elastic structure, mechanical testing.” The relevant literature about the distribution of mechanical structure of aortic blood vessel walls and relevant detection methods were retrieved. Finally, 54 articles regarding mechanical and micromechanical testing were induced for review. RESULTS AND CONCLUSION: The arterial wall is characterized by complex microstructure, which affects the mechanical properties of vascular tissue. The main components include collagen and elastin fibers, proteoglycans, vascular smooth muscle cells, and matrix. These components are often damaged during cryopreservation. Among them, vascular smooth muscle cells play a key role in the active mechanical response of the arteries, and collagen and elastin determine the passive mechanical response. After the treatment of vascular grafts, the technologies of detecting vascular wall skeleton damage still need to be further explored or summarized to obtain a set of more accurate methods, so as to evaluate vascular wall skeleton damage in multiple dimensions and help in [ABSTRACT FROM AUTHOR]

BACKGROUND: Cryopreserved allogeneic blood vessels have broad clinical application prospects in vascular transplantation and repair. Cryopreservation is a common method to achieve long-term preservation of allogeneic blood vessels. During cryopreservation, effective cryoprotectants are essential to prevent vascular tissue hypothermia damage and maintain cell viability. However, there is no consensus on the choice of the best cryoprotectant. OBJECTIVE: To summarize the cryoprotectants used in major vascular tissue banks in recent years and compare their clinical effects, thereby providing a reference for the application of cryopreservation of allogeneic blood vessels in the future. METHODS: The relevant literature included in CNKI, WanFang, PubMed, and Google Scholar databases from 2015 to 2022 was retrieved by the first author. The Chinese search terms were “allogeneic blood vessels, artery, vein, cryopreservation, cryoprotective agent, cryoinjury, vascular transplantation.” The English search terms were “cryopreservation, blood vessels, vascular allografts, arteries, veins, cryoinjury, cryoprotectants, cryoprotective agents.” The relevant literature at home and abroad on vascular cryoprotectants used in clinic and their short-term and long-term results were searched. Finally, 54 articles were selected for review. RESULTS AND CONCLUSION: (1) In the study of cryopreservation of blood vessels, a combination of permeable and non-permeable cryoprotectant is often used to reduce damage to the structure of the vessel wall through programmed cooling and rapid thawing. (2) Despite the toxic effects of dimethyl sulfoxide, tissue bank product lists in many countries do not include any cardiovascular tissue cryopreserved with cryoprotectant other than dimethyl sulfoxide alone. At present, there are still many clinical complications after cryopreservation of allogeneic blood vessels for vascular transplantation, and some are even fatal. (3) As an essential component of protective agent, dimethyl sulfoxide is very important to balance its toxic effect and protective effect. Finding a new type of cryoprotectant that is safe, non-toxic and free of xenogeneic antigens is the main direction of current research, which is very important for the clinical development of allogeneic vascular grafts. [ABSTRACT FROM AUTHOR]

Urban-rural factors have been the most important elements to promote urban-rural linkage and regional cooperation in an urban-rural community of destiny. Various social resources are very necessary for social production and business activities in urban and rural areas. Rural development has been hindered and slowed by the dual system of urban and rural areas in China over a long time. However, only a single flow has been considered in the urban-rural factors. The current relationship between urban and rural areas has shifted from separation to integration. The flow of urban and rural factors has been characterized by the "multi-factors two-way freedom flow", particularly with the national policies leaning toward rural development, and the implementation of national strategies, such as "new urbanization", "rural revitalization", and " integrated urban-rural development ". Furthermore, agricultural production has gradually brought into the various promises of ecological conservation, leisure experience, and cultural inheritance. Rural development has entered an accelerated transformation period. The rural pluralistic values can be expected to realize for the rural revitalization strategy and transformation. It is very necessary to clarify the influencing mechanism of urban-rural factor flow for the rural multi-values in the urban-rural integrated development and all-round rural revitalization. Taking Chongqing in South China as the research area, this study aims to evaluate the flow of urban and rural factors, as well as the realization of rural multi-values. A systematic analysis was implemented on the correlation between rural and urban factor flow and rural multi-values, in order to explore the influence mechanism of rural factor flow, and then to empower the rural multi-values realization and the path of realizing rural multi-values under the flow of urban and rural elements. The results showed that: 1) The correlation logic law was established between rural-urban factor flows and the realization of rural multi-values. The comprehensive effects of population mobility, resource transfer, and social interaction between urban and rural systems were utilized to realize the multiple values in rural areas. Among them, the core, key and driving forces were the population flow, the resource transfer, and the social interaction, respectively. 2) There was a significant spatial difference in the factor flows between urban and rural areas. The population flow was relatively frequent with a spatial pattern of "high in the west and low in the east". There was a small difference in resource transfer, the high integration degree of urban and rural areas, the more interaction between urban and rural systems, and the highly active degree of resource transfer. There was a large difference between urban and rural development in southeast Chongqing and northeast Chongqing. There was a low integration degree of urban and rural, and the low active degree of resource transfer. Social interaction was less with the low activity, indicating a spatial pattern of "low-value series and high-value flower arrangement". 3) Rural multi-values were represented by supply, regulation, inheritance, and service values. The realization degree of rural multi-values was normally distributed with a spatial pattern of "high in the south and low in the north, and flower arrangement in the north". The distribution of flower arrangement in the main metropolitan area was mainly in the middle and low-value areas, while the northeast and southeast of Chongqing were in the middle and high-value areas. Low-value area was less. 4) The rural multi-values were attributed to the comprehensive effects of multiple factors, such as population flow, resource transfer, and social interaction. Population flow shared a significant positive correlation with the supply and adjustment value with a positive promotion, whereas a significant negative correlation was found with the inheritance value with a reverse inhibition effect. Resource transfer presented a significant positive correlation with the supply, adjustment, and service value, indicating a positive promoting effect. Social interaction showed a significant positive correlation to the adjustment and service value with a positive promotion effect, whereas, a significant negative correlation was found in the inheritance value with a reverse inhibition effect. 5) Rural multi-values should be started from three aspects: a new urban-rural relationship with the county territory as an important carrier, in order to establish an institutional channel for the free flow of factors with the full factor flow as the core. The rural value can be expected to realize with the high quality and multi-values in modern agriculture. [ABSTRACT FROM AUTHOR]

BACKGROUND: Gait is one of the optimal indicators of functional status in older adults. Gait parameters are associated with adverse health outcomes in older adults. OBJECTIVE: To summarize and compare the practical value of gait parameters, and to review the progress of research on spatio-temporal parameters and the risk of adverse health outcomes in older adults. METHODS: PubMed, Web of Science, and CNKI were searched for relevant literature published from January 2010 to June 2023 using the search terms of “gait speed, walking speed, step length, cadence, step frequency, step time, walking base, aged and elderly” in English and Chinese, respectively. A total of 52 papers were finally included for the systematic review. RESULTS AND CONCLUSION: Currently, researchers have focused on three basic temporal-spatial parameters, namely, step speed, step length and step frequency, to explore their association with adverse health outcomes in older adults. Reduced gait speed in older adults may increase the risk of falls, all-cause mortality, and may be an independent predictor of all-cause mortality. Older adults with slow gait speed are at higher risk of cognitive decline, and may be the preferred gait parameter in assessing cognitive impairment in older adults. Older adults with slow gait speed are more likely to have debilitating or common chronic illnesses, and are at higher risk of hospitalization and public care. Step length is positively correlated with individual height and lower limb length, but age-induced shortening of step length is not related to height or lower limb length, and shortening of step length reflects reduced physical function in older adults, and shortening of step length is a risk factor for falls and cognitive decline in older adults. Stride frequency is often used as a measure of exercise intensity, and a stride frequency of ≥ 100 steps/minute is predictive of all-cause mortality, and slowing of step frequency may lead to a higher risk of falls, hospitalization and all-cause mortality in older adults. Changes in gait parameters are closely related to the level of physical fitness in older adults, and there may be a bidirectional relationship between the two. The results of the study will provide a theoretical basis for further improving risk screening in clinical populations, refining health risk assessment in the elderly, improving health protection and promoting active health in the elderly. [ABSTRACT FROM AUTHOR]

我国社会经济不断发展的过程中，医疗事业也得到了突飞猛进的发展，药品是医疗行业发展中不可缺失 的重要一环，在药品生产和进入市场之前需要对药品的质量进行检验和控制，从而确保药品生产质量可以满足安全有 效，质量可控的质量属性要求。但是，在实际开展药品检验的过程中，还存在着一定的影响因素，如检验人员能力不 足，检验仪器精度以及样品选取等存在不当会导致整个检验环节受到严重影响，出现药品检验质量风险，检测结果的 准确性存在不足，不仅会影响到药品上市许可持有人、生产企业的经济效益，甚至可能会导致不符合质量标准的药品 流入到市场中，给患者的生命健康带来威胁。基于此，本文对药品检验质量风险进行了分析和探讨，并提出了几项药 品检验质控优化措施，以供参考。 [ABSTRACT FROM AUTHOR]

BACKGROUND: Small-diameter blood vessel prosthesis has a wide application value in the treatment of peripheral vascular diseases, but the problem of graft failure due to early thrombosis needs to be solved. OBJECTIVE: To summarize research progress on early thrombosis and prevention of small-diameter blood vessel prosthesis. METHODS: The relevant literature published on CNKI, Wanfang, PubMed, and Google Scholar databases from 2000 to 2020 was retrieved by the first author. The Chinese search terms were “small-diameter blood vessel prosthesis, small-diameter tubular stents, tissue-engineered blood vessels, antithrombotic, thrombosis, hemocompatibility, hydrophilicity, endothelialization”. The English search terms were “small-caliber vascular graft, vascular tissue engineering applications, endothelialization, hemocompatibility, surface modification”. The relevant literature on the pathophysiological mechanism and prevention of small-diameter blood vessel prosthesis thrombosis in China and abroad was retrieved, and the surface modification and endothelialization of biological materials were taken as the inclusion criteria. Finally, 57 articles were selected for review. RESULTS AND CONCLUSION: Prevention of thrombosis is a hotspot and a difficulty in the study of small-diameter blood vessel prosthesis. The research progress at home and abroad in recent years shows that the early thrombosis of small-diameter blood vessel prosthesis is related to plasma protein adsorption and contact activation of coagulation factors. By improving the surface hydrophilicity, releasing antithrombotic substances, planting seed cells and target gene induction, the thrombosis of small-diameter blood vessel prosthesis has been improved to a certain extent, but it is still in the experimental stage, and there is still a certain distance from clinical application. Therefore, it is necessary to further explore or optimize a more suitable vascular material to provide more choices for clinical application. [ABSTRACT FROM AUTHOR]

The modified sludge derived biochar BC-Fe, BC-RM and BC-Ca was prepared by co-pyrolysis of metal oxide add让ives (Fe2O3, red mud and CaO) and sewage sludge at a mass ratio of 1 ： The influence of additives on the characteristics of the sludgebiochar, as well as the speciation distribution of heavy metals (Pb, Zn, Cu, Cr, Mn) were investigated ・ The ecological risk of the biochar was assessed based on the risk assessment code (RAC)・ The results showed that compared with unmodified biochar (BC), the specific surface area of the three modified sludge derived biochar increased by 58.08%, 189. 58% and 122.99%, respectively, and the microstructure performance of the sludge derived biochar was improved in the meantime・ The study also revealed that Fe2O3 prevented Zn escaping from sludge derived biochar during pyrolysis process・ In addition, compared with BC, the fraction of residual state (F4) of Zn, Pb, Cr, Mn and Cu in BC-Ca increased by 1L76%,13. 03%, 26. 96%, 5. 55% and 2. 11 %, respectively. Heavy metals investigated in the BC-Ca were all in a low risk cond让ion according to the RAC risk assessment standard. [ABSTRACT FROM AUTHOR]

Objectives The study aims to facilitate China’s hydrogen energy industry and improve the quality of hydrogen, as well as solving the technical problem of argon impurity quantification due to the difficulty of effective separation of oxygen and argon in hydrogen quality analysis method. Methods An analytical method for accurate determination of trace argon impurity in hydrogen based on chromatographic correction factor is established. Firstly, the helium ionization gas chromatographic method is established through the self-prepared reference materials of argon in hydrogen and oxygen in hydrogen, along with the correction factors of oxygen and argon on the helium ionization gas chromatograph are researched; Secondly, the response relationship between oxygen and argon is calculated, while the long-term stability of which is investigated; Thirdly, by using the micro oxygen analyzer, the oxygen impurity content in hydrogen is measured. Results The argon impurity content in hydrogen is accurately determined according to the response relationship between oxygen and argon. Conclusions A new method combined helium ionization gas chromatography with electrochemical method is first proposed for the determination of trace argon impurity in hydrogen. It provides the guarantee on the accuracy data of argon content in hydrogen with the advantages of simplicity, strong operability and wide determination range, making up for the deficiency of argon impurity analysis method. Furthermore, the application of this method has great potential on the evaluation of the hydrogen quality. [ABSTRACT FROM AUTHOR]

[Objective/Meaning] The current situation of different types of rural-urban elderly migrants was analyzed in this paper, in order to provide decision-making reference for guaranteeing the rights and interests of the floating elderly population and promoting the citizenization of the agricultural transferring population. [Methods/Procedures] Based on the dynamic monitoring survey data of the floating population in China in 2017, the binary logistic regression model was used to reveal the long-term residence intention and influencing factors of different types of elderly floating population. [Results/Conclusions[ The study found that: (1) The long-term residence intention of the elderly floating population decreased in the order of the types including the non-local elderly care service, other type, the accompanying transferring of family members, and farmers ’doing business or seeking jobs in cities. (2) The long-term residence intention of the elderly floating population had the characteristics of obvious spatial agglomeration. The high-value areas were mainly distributed in the northeast and western regions of China, while the low-value areas were concentrated in the eastern region of China. (3) The type of household registration, the duration of inflow, the housing nature, the willingness to integrate and family difficulties were the main factors that determined the residence intention of all types of elderly floating population. In addition, there were significant differences in the dominant factors affecting the long-term residence intention of different types of elderly population. [ABSTRACT FROM AUTHOR]

Objective：To compare the cutting abilities and shaping abilities of three kinds of single formed nickel-titanium instruments for the simulated curved root canals, and to provide the basis for their clinical applications. Methods：A total of 40 single curved resin simulated root canals were selected and randomly divided into Reciproc Blue group, WaveOne Gold group, M3-L group, and ProTaper Gold group, and there were 10 single curved resin simulated root canals in each group. The simulated root canals in each group were prepared according to the user manuals, and the preparation time, difference in weights of simulated root canals before and after preparation, difference of bending angles of simulated root canals, apical deviations, removal amounts of internal and external resin, centering ratios of simulated root canals in various groups were recorded. Results：The preparation time of the simulated root canals in WaveOne Gold group was shorter than those in the other three groups (P<0.05), and the preparation time of the simulated root canals in ProTaper Gold group was longer than those in the other groups (P<0.05). There was no significant difference in wieight of the simulated root canals among four groups before and after preparation (P>0.05). The differences of bending angles of the simulated root canals in M3-L group before and after preparation was smaller than those in the other three groups (P<0.05). After preparation, the removal amount of internal resin of the apical zone (1－4 mm)was larger than extermal resin (P<0.05), and the removal amount of external resin of the middle zone (5－8 mm)was larger than internal resin (P<0.05)；at the positions 1, 3 and 6 mm from the apical foramen, the differences between the centering ratios of the simulated root canal in ProTaper Gold group and 1 was the largest, which was larger than those in the other three groups (P<0.05), and the differences between the centering ratio of the simulated root canals and 1 at each observation point in the other groups were not statistically significant (P>0.05). Conclusion：Reciproc Blue, WaveOne Gold and M3-L single formed nickel-titanium instruments can keep the shape of root canals better, and have better preparation efficiencies and center positioning ability than the ProTaper Gold multi-file system. Domestic single nickel-titanium instrument M3-L can better maintain the original curvature of the root canals. [ABSTRACT FROM AUTHOR]

Objective To investigate the risk factors for early recurrence of resectable pancreatic cancer and the establishment and application of a grading system. Methods A retrospective case-control study was conducted among 303 patients with resectable pancreatic cancer who underwent radical resection in Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, from March 2015 to June 2021, and according to the presence or absence of early recurrence (within 6 months after surgery), the 283 patients directly operated on were divided into early recurrence group with 95 patients and non-early recurrence group with 188 patients; 20 patients who received neoadjuvant therapy before surgery were enrolled as neoadjuvant therapy group. Observation indicators included general information, preoperative imaging data, preoperative laboratory data, routine blood test/blood biochemistry and derived indicators, tumor markers, and coagulation markers, and follow-up was conducted to observe recurrence-free survival. The t-test was used for comparison of normally distributed continuous data between two groups, and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups; the chi-square test was used for comparison of categorical data between two groups. A multivariate Logistic regression analysis was used to investigate the risk factors for early recurrence in patients with pancreatic cancer, and the receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value of each indicator. The Kaplan-Meier curve was plotted, and the Log-rank test was used for comparison of recurrence-free survival time between groups. Results The univariate analysis showed that compared with the non-early recurrence group, the early recurrence group had significantly lower body mass index (BMI) and triglyceride and significantly higher CA19-9, CA242, CA125, and plasma fibrinogen (all P < 0.05). The multivariate logistic regression analysis showed that BMI (odds ratio [OR]=1.150, 95% confidence interval [CI]: 1.038-1.273, P=0.007), plasma fibrinogen (OR=2.513, 95%CI: 1.355-4.663, P=0.003), and CA242 (OR=2.482, 95%CI: 1.067-5.774, P=0.035) were independent risk factors for early recurrence in patients with resectable pancreatic cancer. BMI, CA242, and plasma fibrinogen were included in the grading system, with a cut-off value of 23.00 kg/m², 30.0 U/mL, and 4.00 g/L, respectively. BMI < 23.00 kg/m² was counted as 1 point, otherwise it was counted as 0 point; CA242≥30.00 U/mL was counted as 1 point, otherwise it was counted as 0 point; plasma fibrinogen ≥4.00 g/L was counted as 1 point, otherwise it was counted as 0 point; the total score was 0-3 points. The patients in both the early recurrence group and the non-early recurrence group were scored, and the results showed that the early recurrence group had a significantly higher score than the non-early recurrence group [2(0-3) points vs 1(0-3) point, Z=-5.339, P < 0.001]. The Kaplan-Meier curve analysis showed that there was a significant difference in time to recurrence between groups (χ²=28.116, P < 0.001), and the higher the score, the shorter the expected time to recurrence. The patients with 3 points were defined as high-risk group and those with 0-2 points were defined as low-risk group, and the early recurrence rate was 84.6% in the high-risk group and 31.2% in the low-risk group. Conclusion The grading system based on BMI, plasma fibrinogen, and CA242 can reliably predict postoperative recurrence. [ABSTRACT FROM AUTHOR]

Pancreatic cancer is known as the " king of cancer". The incidence and mortality of pancreatic cancer are increasing year by year worldwide. The prognosis of pancreatic cancer is very poor, and the effect of existing diagnosis and treatment methods is limited. The Oncologist Branch of the Chinese Medical Doctor Association, the Pancreatic Disease Special Committee of the China International Exchange and Promotive Association for Medical and Health Care, and the Abdominal Tumor Special Committee of the China Medical Education Association convened relevant experts to put forward useful suggestions for clinical reference on nine aspects of home management of patients with pancreatic cancer, including condition communication, follow-up, nutritional support, cancer pain management, psychological adjustment, ascites management, jaundice management, and daily food management. The aim is to improve the quality of life and prolong the survival time of patients with pancreatic cancer. [ABSTRACT FROM AUTHOR]

A coagulation factor 8（F8）gene knockout mouse model was constructed based on CRISPR/Cas9 technique and its phenotype was verified. sgRNA target sites were designed according to exon 1 non-coding region to exon 26 downstream sequences of F8 gene，the sgRNA was obtained from in vitro transcription and mixed with mRNA of encoding Cas9. F0 generation positive knockout mice were obtained by microinjection of fertilized eggs. F8 -/- gene knockout homozygous mice（F8-/- mice）were obtained by breeding and genotype identification. The expression of F8 gene at mRNA level in main tissues was detected by reverse transcription PCR（RT-PCR），the protein expression of F8 gene in plasma was detected by enzyme-linked immunosorbent assay（ELISA），and the coagulation function of F8 knockout mice was detected by activated partial thromboplastin time（APTT）and fibrinogen content（FIB）. PCR and sequencing results showed that F8 gene was knocked out successfully in mouse genome，and RT-PCR and ELISA results demonstrated that the expression of F8 in F8-/- mice was significantly lower than that in wild-type mice（WT mice）（P < 0.0001，P<0.01）. APTT，FIB and drop blood test results revealed that the plasma coagulation time of F8-/- mice was significantly longer than that of WT mice. F8-/- mice had severe coagulation disorder phenotype， which restored to normal levels after administration of human factor VIII. The F8 gene knockout mice model is successfully constructed by CRISPR/Cas9 technique and its phenotype is preliminarily verified，which confirms that the deletion of F8 gene can lead to coagulation dysfunction. [ABSTRACT FROM AUTHOR]

To investigate the curative effect of sinus enlargement and opening partial middle turbinate resection combined with nerve branch block in patients with refractory sinusitis. Methods　A total of 60 patients with refractory sinusitis admitted to the Otolaryngology Department of The Second People’s Hospital of Qujing city from May 2019 to May 2021 were selected and divided into 2 groups by random number table method. The control group （n = 30 cases） was treated with sinus enlargement and middle turbinate resection，while in the study group （n = 30 cases），sinus enlargement，middle turbinectomy and nerve branch occlusion were performed. The effective rate， recurrence rate， visual analogue scale （ VAS）， clinical symptom score and clinical level indexes of the two groups were observed and analyzed. Results　The effective rate of operation in the study group was higher than that in the control group，and the recurrence rate was lower than that in the control group. The differences were statistically significant （P = 0.021，0.007）. VAS scores of 3 months，6 months and 1 year after the operation in the study group were lower than those in the control group and the differences were statistically signi icant （P = 0.041，0.039，0.017）. The clinical symptom score of the study group was lower than that of the control group and the differences were statistically significant （P = 0.028，0.037，0.010，0.022）. EOS，IFN-γ and basophils in the study group were better than those in the control group，and the differences were statistically significant （P = 0.029，0.003，0.045）. Conclusion　The treatment of refractory sinusitis with sinus enlargement， middle turbinate resection and nerve branch block can relieve the clinical symptoms and reduce the recurrence rate， which is worthy of application. [ABSTRACT FROM AUTHOR]

The classification of nano flooding technology and the research status of micro and macro flooding mechanisms are reviewed ・ The five major applications of intelligent nano flooding technology are introduced, and the advantages of this technology and conventional flooding technology are compared・ The performance effect, cost, safety and environmental protection analysis of the challenges faced by intelligent nano flooding technology, and give forwardoking development suggestions. [ABSTRACT FROM AUTHOR]

In this paper, Standard ke, RNG ke and Realizable ke are three turbulence models of high Reynolds number are used to simulate the CAARC model under different meshing, different wind fields environment, and different wind directions. The numerical simulation results were compared with wind tunnel test data at home and abroad, the conclusions are as follows: (1) The precision of the building boundary layer grid model has an important influence on the simulation results. When the best grid model is selected for simulation, the RMSE of RNG ke model is equal to that of wind tunnel test data, and the root mean square error of RNG model is 50% - 70% less than that of sparse grid model, and the error of other two models is about 40% - 50%. (2) In the case of B-type and D-type wind farms, the variation area and trend of the average wind pressure coefficient obtained by RNG ke model are basically the same, and there is no obvious difference, while the variation trend of the other two models is in different wind farms. The change range of environment is also very different, the difference is mainly reflected in the crosswind side and leeward side of the building. (3) On the leeward side, the average error of the model is about 90% smaller than that on the leeward side, and about 5% lower than that of the other two models. Generally speaking, under different simulation conditions, the accuracy, stability and regularity of the results obtained by RNG ke model are higher than those of the other models. [ABSTRACT FROM AUTHOR]

For the poor adhesion of superhydrophobic properties, the stability of surface superhydrophobic properties is improved. The effects of groove depth, bulge width and groove depth on contact angle were studied by 0. 05, 0. 10, 0. 15, 0. 20 mm micro-milling cutter on red copper surface, and low surface energy modification with stearic acid and alcohol mixture solution. The maximum contact angle is 157. 4° when the groove width is 0. 20 mm and the minimum contact angle is 81. 2°. With the increase of protruding width, the contact angle increases greatly first, then decreases slowly. When the protruding width is 0. 07 mm, the maximum contact angle is 159. 2°. The minimum contact angle is 144° when the groove width is 0. 20 mm. With the increase of groove depth, the contact angle will increase and then decrease. When the groove depth is 0. 03 mm, the maximum contact angle is 168°. The minimum contact angle is 101. 7° when the groove depth is 0. 02 mm. A large number of irregular microstructures will be found. When the surface of liquid and workpiece is in contact with each other, the surface becomes smaller and the contact angle becomes larger. [ABSTRACT FROM AUTHOR]

This study aims to explore the effect of flooding and waterlogging at the jointing stage of summer maize on the formation mechanism of yield in the Huaibei plain. Taking Denghai 605 as the test material, two treatments of water stress (including flooding and waterlogging) were carried out in a field experiment in the Wanbei experimental station of Anhui Agricultural University in 2018 and 2020. The normal water supply was also used as the control (CK). The parameters were analyzed, such as growth process, photosynthesis traits, dry matter accumulation, lodging resistance traits, male-female interval, ratio of leaf to grain, and yield of summer maize. The results showed as follows. 1) The duration from the jointing to silk and anthesis-silking interval were significantly (P<0.05) increased, compared with the CK, and the flooding treatment was significantly (P<0.05) greater than the waterlogging treatment. 2) The leaf area per plant, the chlorophyll content, and net photosynthesis rate (Pn) from the big trumpet to dough stage significantly (P<0.05) decreased in the flooding treatment, compared with the CK. The leaf area per plant from big trumpet to dough stage significantly (P<0.05) decreased in the waterlogging treatment, compared with the CK. The chlorophyll content and net photosynthesis rate only at big trumpet stage significantly (P<0.05) decreased in the waterlogging treatment, compared with the CK. 3) The dry matter accumulation of leaf, stem, ear, and whole plant from the big trumpet to maturity were significantly (P<0.05) reduced in the flooding and waterlogging treatment, compared with the CK. The dry weight of the whole plant is the most critical physiological index affecting the yield, and the rates of decrease were 53.99% and 23.65% for the dry matter accumulation of whole plant in the flooding and waterlogging treatment, respectively.4) The stem diameter and puncture strength were significantly (P<0.05) reduced in the flooding treatment compared with the CK. Meanwhile, the lodging rate significantly (P<0.05) increased in the flooding treatment, where the rate of increase was 78.53% compared with the CK. 5) The empty rods rate significantly (P<0.05) increased in the flooding and waterlogging treatment compared with the CK. The number of grains per ear is the most critical yield component factor affecting yield, and the grains number per ear and yield of summer maize significantly (P<0.05) decreased in the flooding and waterlogging treatment, compared with the CK, where the rates of decrease for the grain number per ear were 44.48% and 30.61%, respectively, whereas, those for the yield were 57.26% and 34.68%, respectively. The 1000-grain weight and the leaf area and number of grains per leaf were significantly (P<0.05) reduced in the flooding treatment, while, that significantly (P<0.05) increased in the waterlogging treatment, compared with the CK. The findings can provide a theoretical and technical support to the decision-making on the summer maize production in areas prone to the waterlogging disaster. [ABSTRACT FROM AUTHOR]

Objective To investigate the expression level and potential clinical value of serum HBV RNA in HBeAg-positive chronic hepatitis B（CHB） patients at different periods. Methods A total of 61 CHB patients who attended the outpatient and inpatient services of Department of Hepatology, Hangzhou Xixi Hospital, from August 2019 to December 2020 were enrolled, and according to the antiviral therapy for HBeAg-positive CHB patients, they can be divided into group A with untreated HBeAg-positive CHB（HBeAg+ and HBV DNA+） patients, group B with treatment-experienced patients before HBeAg seroconversion（HBeAg+ and HBV DNA-）, and group C with treatment-experienced patients after HBeAg seroconversion（HBeAg-and HBV DNA-）. Peripheral blood HBV RNA load was measured at different periods, and its correlation with HBsAg and HBV DNA was analyzed. The t-test was used for comparison of normally distributed continuous data between groups, and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups; the chi-square test was used for comparison of categorical data between groups; a Pearson or Spearman correlation analysis was used to describe the correlation between two variables. Results The positive rates of HBV RNA in these three groups were 100%（22/22）, 88.2%（15/17）, and 22.7%（6/22）, respectively. In group A, HBV RNA was positively correlated with HBsAg and HBV DNA（r=0.612 and 0.922, both P<0.01）, while in groups B and C, there was no correlation between HBV RNA and HBsAg. Group B had significantly higher levels of HBV RNA and HBsAg than group C（Z=-4.44 and-2.41, both P<0.05）. The HBV DNA-positive group had a significantly higher level of HBV RNA than the HBV DNA-negative group（Z=-6.16, P<0.01）. Conclusion After HBV DNA clearance achieved by antiviral therapy with nucleos（t）ide analogues in CHB patients, serum HBV RNA can still be detected in some of these patients. Since HBV RNA only comes from cccDNA in the liver, it can better reflect viral replication activity in the liver than HBV DNA and thus has a certain clinical value in the management of CHB patients. [ABSTRACT FROM AUTHOR]

Vibration frequency and energy in CNC milling process can indirectly reflect the influence of vibration on the surface quality of milling process. First,the principle of vibration test system is introduced,and then the frequency and energy data of milling system are tested by milling 6061-T651 aluminum alloy U slot. According to the obtained detection data,the vibration frequency and energy peak of milling machining under different spindle speed,different feed speeds and different milling depth are analyzed respectively. Analysis results show that when the spindle speed is less than 1 400 r/ min,the peak vibration energy increases and the cutting surface quality becomes worse. To improve the surface quality of machining workpiece,if the feed quantity per tooth is more than 0. 037 mm,the corresponding spindle speed is 1 400 r/ min,the vibration amplitude of nonlinear change will increase greatly. It is due to the small spindle speed and the increase of feed quantity per tooth,and results in the impact effect caused by the excessive torque borne on the machine tool spindle. With the increase of feed speed, the peak energy also increases gradually,indicating that the vibration increases with the increase of feed speed. The faster the feed speed,the greater the vibration of the system. The greater the depth of milling,the greater the vibration amplitude of milling and the worse the surface quality of milling. Thus it is necessary to reduce the milling depth in order to improve the surface quality. [ABSTRACT FROM AUTHOR]

The Lucaogou Formation reservoir of Jimu sar shal e oil in Xinjiang Oilfield Company has the characteristics of low porosity and low permeability, no developmental edge and bottom water, thin oil layer with well developed bedding plane, and thick oil quality. In the early stage, the open-hole packer completion fracturing technology had realized the new production and high yield of some single wells, but there was a lack of effective refracturing technology for open-hole packer completion horizontal wells. Aiming at the above problems, the research on multi-stage temporary plugging and refracturing technology was carried out. Through the experimental study on the key temporary plugging agent, it was found thee the temporary pluggin agent had t he advantages of pressure bearing of more than 60 Ml'a and dissolution rate of less t h an 3 % wit h in 6 days. The field test results of the selected temporary plugging agent it was good, and the oil output of typical Ji after fracturing was 47.5 t per day. This technology breaks the traditional idea that open-hole packer horizontal wells cannot be re fractured, and provides a reference for similar reservoirs and similar processes at home an d abroad. [ABSTRACT FROM AUTHOR]

In order to study the effects of preload on the residual stresses induced by surface mechanical rolling treatment（SMRT）, the three-dimensional finite element models in conjunction with a novel computation framework coupling the explicit dynamics and implicit statics were developed to simulate the process of surface mechanical rolling of AISI 4340 steel under preload. At first, the elastic deformation was produced in the finite element model to be surface mechanical rolled by applying the displacement load. Secondly, the displacement-preloaded side was completely constrained for freezing the displacement-induced elastic deformation. On this basis, the surface mechanical rolling of the finite element model with the freezing elastic deformation was then carried out. Lastly, the residual stresses induced by surface mechanical rolling treatment were comparatively studied after the freezing elastic deformation was released. The obtained results show that the surface mechanical rolled materials can produce the unfavorable tensile residual stresses in the treated surface, and the maximum compressive residual stresses can be reduced if the preloading direction is opposite to the direction of rolling pressure. The compressive residual stresses in the subsurface of surface mechanical rolled materials can be further reduced when the preload is released. It is therefore necessary to avoid the preload in the surface mechanical rolling process. [ABSTRACT FROM AUTHOR]

Objective·To study the role and mechanism of mucin 1 (MUC1) in the pathogenesis of HER2-positive breast cancer. Methods·Virus infection technology was employed to construct MT2/MUC1 and MT2/Vec/MUC1-CD overexpression cell lines; Western blotting was used to detect the expression level of relative proteins; the ability of cell proliferation, migration and sphere formation were detected by using cell counting kit-8 (CCK-8), colony formation, wound healing, transwell and sphere formation experiments respectively; inhibitor 6-AN was used to inhibit glucose-6-phosphate 1-dehydrogenase (G6PD) activity, and the proliferation of breast cancer cells was detected by CCK-8. GEPIA and Kaplan-Meier Plotter database were analyzed to figure out the relationship of HER2, MUC1 and G6PD expression with the survival of breast cancer patients. Results·Overexpression of MUC1 or MUC1-CD promoted the proliferation, clone formation, migration and sphere formation of MT2 HER2-positive breast cancer cells, as well as elevating the protein level of G6PD. Inhibition of G6PD activity significantly reduced cell proliferation induced by MUC1 and MUC1-CD. High level of G6PD protein in breast cancer tissues is associated with significantly lower survival of breast cancer patients. Conclusion·MUC1 may promote the progression of HER2-positive breast cancer by up-regulating the expression of G6PD, suggesting that inhibition of the pentose phosphate pathway may be a target for the treatment of HER2-positive breast cancer. [ABSTRACT FROM AUTHOR]

Although deep learning-based image coloring methods have achieved significant results, but there are still suffer from three problems: redundant stain, color dimming, and color deviation. To this end, this paper proposed an instance image coloring method combined with fine-grained attention (fine-grain self-attention, FGSA). Specifically, it firstly divided the extracted feature maps into color and spatial location, and combined the two parts of the fittingto improve the correspondence between the color and the spatial location of the image to mitigate the redundant color patches. Secondly, inspired by the principle of HDR for optical photography, it utilized convolutional kernels with small sensory fields to enhance or suppress the color features of the image, and combined them with softmax to dynamically map the features, thus improving contrast and alleviating the darkness of the coloring. Finally, combining different nonlinear basis functions increased the network’s representation of nonlinear colors and fitted a color distribution that was closest to the real image to address color bias. Extensive experimental results show that the proposed method achieves satisfactory results in instance image coloring. In particular, compared with the state-of-the-art methods, the proposed method improves 4.1% and 7.9% in feature perception evaluation indexes LPIPS and FID, respectively. [ABSTRACT FROM AUTHOR]

[Objective] The purposes of this study are to elucidate the long-term trends and periodic characteristics of runoff in the Dagu River Basin, and to offer the theoretical insights to guide water resource management and promote sustainable development in the Dagu River Basin. [Methods] The measured runoff data from the Nancun Hydrological Station（1956—2020） and the Zhazi Hydrological Station（1956—2016） were used to analyze the trend of annual runoff changes and abrupt change times using the Mann-Kendall test and sliding t-test. The Morlet continuous complex wavelet method was used to analyze the periodic characteristics of multi-year runoff in the basin. [Results] The annual runoff in the Dagu River Basin was generally declining, and there was a characteristic of more flow during the flood season（June—September） and less flow during the non-flood season. The peak flow usually occurred in August. The runoff of Nancun Station was abrupt in 1976, and the runoff of Zhazi station was abrupt in 1979. The runoff of the Dagu River Basin exhibited significant periodic variations at multiple time scales, with a dominant period of around 20 years, and significant oscillations before the 1980s. [Conclusion] The long-term series runoff of Dagu River Basin showed a trend of significant decline, and the basin runoff suddenly changed in the 1970s, and there were periodic changes in different time scales. In the future, the research on the mechanism of runoff change should be strengthened. [ABSTRACT FROM AUTHOR]

This study explored ways to improve the efficiency of rural domestic waste sorting treatment from the perspective of the participation of farmers. Firstly, we theoretically analyzed the participation of farmers in rural domestic waste sorting treatment and the associated impact on treatment efficiency. Second, based on the2019survey data from187villages in Hangzhou City, Zhejiang Province, the DEA（Data envelopment analysis）model was used to measure the efficiency of rural domestic waste sorting treatment with the participation of farmers. The Tobit model was used to analyze the impact of the participation of the farmers on treatment efficiency. Finally, the influence of the participation of farmers on the efficiency of rural domestic waste sorting treatment was further analyzed from the input–output perspective. The results indicated a low average rural domestic waste sorting treatment efficiency of0.58. The direct participation behaviors of farmers, such as the waste sorting awareness rate and supervision behavior, had a significant positive impact on the efficiency of rural domestic waste sorting treatment. Additionally, indirect participation, such as payment behavior, had a significantly negative impact on efficiency. The direct and indirect participation of the farmers affected input and output and impacted the efficiency of rural domestic waste sorting treatment. Based on the research conclusions, local governments should propose relevant measures to improve the efficiency of rural domestic waste sorting treatment. These measures could include reasonably increasing waste sorting treatment, strengthening publicity and education related to domestic waste sorting, guiding the domestic waste sorting of farmers, and establishing incentive mechanisms for farmers to participate in domestic waste sorting. [ABSTRACT FROM AUTHOR]

For the cable force adjustment of cable-stayed bridges, truss elements were used to simulate the cables, and the amount of inelastic contraction was introduced into the degree-of-freedom vector of the cables. Through matrix transformation of the overall structural balance equations, an influence matrix based on the amount of inelastic contraction was established. With the obtained influence matrix, in the case of the full-bridge cable adjustment, the target cable force can be accurately achieved in theory. In response to the needs of some cable adjustments in actual projects, variables 0 and 1 were introduced to indicate that no adjustment is needed, or some cable is to be adjusted. Based on the integer variables and the adjustment length of the cable, a mixed integer optimization model was established to conveniently realize partial cable adjustment and optimization analysis of the cable. The calculation example demonstrates the effectiveness and feasibility of the optimization model. [ABSTRACT FROM AUTHOR]

BACKGROUND: The main types of copper deposits are porphyry and skam types. Dacite porphyry is a rock type commonly developed in the porphyry Cu - Mo - Au system. The rock can be used for prospecting sign and ore - forming rock when there is well - developed hydrothermal alteration. The Dabaoshan deposit is currently the largest copper polymetallic deposit in South China Block. Previous studies have shown that the dacite porphyry of the mining area is not only the ore - forming parent rock, but also a favorable ore - bearing wall rock. However, there are some debates about the relationship between dacite porphyry and mineralization in this mining area. With the breakthrough of prospecting for medium and large dacite porphyry ore bodies in recent years, the relationship between dacite porphyry and mineralization has once again become a concern. OBJECTIVES : In order to understand the relationship between dacite porphyry alteration and mineralization of the Dabaoshan deposit. METHODS: Based on field work and indoor analysis, this paper uses X - ray fluorescence spectrometry ( XRF) and inductively coupled plasma - mass spectrometry ( ICP - MS) to determine copper, tungsten, silicon, aluminum and calcium in Dabaoshan dacite porphyry samples. The isotope composition, metal element contents and alteration characteristics of the dacite porphyry in the mining area were used to discuss the relationship between alteration and prospecting direction. RESULTS: The copper content changes from 107 to 6909 µg/ g, which is consistent with the copper ore grade of 0. 3% - 0. 5% in the mining area. The LOI and other geochemical indicators that can represent the degree of alteration are positively correlated with copper. Hydrothermal alteration is widely developed in dacite porphyry, including potassium, prophyliticition and quartz - sericitization from early to late stage. Among different stages of alterations, the copper content of quartz - sericitization is 2 to 5 times higher than other alteration types, indicating that quartz - sericitization is closely related to copper mineralization and is an important prospecting sign. CONCLUSIONS: The deep alteration intensity of the dacite porphyry ( below the 270m elevation) has not been weakened, suggesting a great prospecting potential. In addition, the contact zone between dacite porphyry and the Jurassic strata, and the xenoliths in the dacite porphyry are also important prospecting directions, which may host skarn - type copper - rich deposits. [ABSTRACT FROM AUTHOR]

Pancreatic cancer, with the characteristics of insidious onset, easy metastasis, chemotherapy resistance and poor prognosis, is a common malignant tumor of the digestive system. Early diagnosis and treatment of pancreatic cancer is one of the major problems in modern medicine, and there is an urgent need to find new diagnostic, prognostic biomarkers and therapeutic targets. MicroRNA (miRNA) is a small non-coding RNA which can regulate the expression of various genes. miRNAs have wide abnormal expressions in pancreatic cancer, and are closely related to the occurrence and development of pancreatic cancer. Thereby, miRNAs have the potential to become new diagnostic, prognostic and predictive biomarkers and therapeutic targets of pancreatic cancer. Many studies have initially shown that miRNAs have the application value in the diagnosis, treatment and prognosis evaluation of pancreatic cancer, but there are still some difficulties in the practical application and promotion. The mechanisms of miRNAs in pancreatic cancer remain to be further studied. [ABSTRACT FROM AUTHOR]

Taking a combine harvester as research object, based on the sound intensity test technology, the surface acoustic intensity of the harvester was tested by p-p method. According to the sound intensity distribution results of each test surface, the main noise sources of the harvester were analyzed and identified. The test results show that when the harvesting machine cutting, threshing, cleaning and other operating mechanisms stop working (that is, when the combine harvester is not in operation), the main noise source of each test surface is from the engine. When the cutting, threshing, cleaning and other operating institutions work normally (that is, when the harvester is under working condition), the main noise sources of each test surface are different. The front noise source is mainly from the engine, the header device and the intermediate conveying device，while the back end noise source is mainly from the threshing device, the cleaning device and the engine exhaust system. The left side noise source is mainly from the header device and the threshing device，and the right side noise source is mainly from the engine and header device. [ABSTRACT FROM AUTHOR]

According to the requirement of automatic parking system for identifying the parking slot by visual method, a parking slot recognition algorithm was proposed based on image gradient and Gaussian weighted cosine distance. The acquired parking space image was de-distorted, and the inverse-perspective transformation was performed to generate a top view. The gray processing and the image filtering processes were performed. The gradient of the preprocessed image was extracted by the Sobel operator, and the parking space position of parking slot was selected. An image gradient template was created, and a rotation template was created by bilinear interpolation to detect parking spaces at different angles. The Gaussian weighted cosine distance was used as the similarity measure to detect the position of parking slot in the image. The termination condition of the algorithm was designed to improve the speed of the algorithm. The experimental results show that the multiple parking spaces can be recognized under different working conditions by the proposed algorithm with fast recognition speed and not easy affecting by cracks on the road surface. [ABSTRACT FROM AUTHOR]

Pancreatic cancer(PC) remains one of the most challenging malignant tumor in gastrointestinal cancer, and the incidence and mortality rates are significantly increased in the past decades. The 5-years survival rate of PC is less than 8% since its dormant clinical symptoms and lacking of sensibility and specificity markers in early diagnosis. The early diagnosis of pancreatic cancer is a worldwide problem, and the early diagnosis rate is only 5%. Increasing early diagnosis rate is the key to improve the overall prognosis of pancreatic cancer. The key of early diagnosis and treatment of pancreatic cancer is to identify the high-risk population of pancreatic cancer, improve the sensitivity and specificity of early diagnosis technology, standardize the process of early diagnosis of pancreatic cancer, and standardize the treatment of early pancreatic cancer. To this end, this expert consensus is formulated. [ABSTRACT FROM AUTHOR]

The current situation of pancreatic cancer is that the etiology is not clear and prevention is impossible. The sensitivity and specificity of the auxiliary detection methods are low,and early diagnosis is a worldwide problem. The efficacy of existing treatment methods is not satisfactory,and it is difficult to break through in a short time. The overall 5-year survival rate is only 7. 2%. In the face of the current situation of pancreatic cancer,the solution to the key problems is to strengthen basic research,explore its etiology and pathogenesis,remove the cause,cut off the path of occurrence and development,which is the only correct way to overcome pancreatic cancer. It is an important way to significantly improve the efficacy by developing peripheral blood,urine detection technology with high sensitivity and specificity,imaging diagnosis technology,and improving the early diagnosis rate. However,the research on basic and early diagnostic techniques takes a long time and costs a lot,which makes it difficult to achieve results in a short time. Therefore,the problem to be solved urgently is to develop a personalized treatment plan through standardized MDT,optimized combination of existing diagnosis and treatment methods,so as to achieve the purpose of improving the efficacy. This expert consensus is developed from the first edition,which is based on the diagnosis and treatment status of pancreatic cancer and the dilemma that is difficult to break through in a short time,with reference to the successful diagnosis and treatment experience at home and abroad,combined with the national conditions of our country,after repeated deliberation,discussion and revison by many well-known experts in the domestic industry. This consensus discusses the meaning and purpose,the main tasks,the necessary objective conditions for carrying out,workflows,precautions,relevant clinical and basic research of MDT,multi-center MDT and eMDT mode exploration in detail. Through the formulation and publication of this consensus,we hope that it can help to promote the standardized development of pancreatic cancer MDT and improve the efficacy of pancreatic cancer in China,to summarize successful experience and promote international exchanges,to strengthen personnel training and echelon construction,to formulate relevant policies and promote the development of MDT in the whole country. This consensus is expert consensus on the MDT model developed in China,which is not only applicable to pancreatic cancer,but also can be used as a reference for other tumors. [ABSTRACT FROM AUTHOR]

With the development of China' s urbanization process, the coexistence of urban expansion and contraction has emerged, and the strategic mode of growth-oriented urban planning as a top-level design in the past needs to be adjusted. In order to objectively reveal the phenomenon of urban shrinkage in China, a comprehensive evaluation index system for urban shrinkage in China was constructed. This study used the shrinkage model, the subjective and objective weighting method, and multi-index comprehensive evaluation method to evaluate the driving mechanism of urban shrinkage in 288 prefecture-level cities or above in China. The gray correlation analysis in the DPS software explored the driving mechanism of urban shrinkage, and proposed the corresponding counter measures. The results show that: ① From the number and severity of the shrinking cities, there were 10 comprehensively shrinking cities, 41 population-related shrinking cities, 28 economy-related shrinking cities, and 3 society-related shrinking cities from 2011 to 2017, and different types of shrinking cities showed regional differences in severity. ② From the perspective of the spatial and temporal evolution of urban shrinkage, the number of shrinking cities from 2014 to 2017 showed a significant increase in comparison with that in the 2011-2014 period. The spatial distribution was mainly in the northeast region, and began to spread in other provinces and regions across the country. ③ From the perspective of long-term contraction and short-term contraction, whether they were comprehensively shrinking cities or population, economy or society-related shrinking cities, they were concentrated in the northeast region, and the number of long-term shrinking cities was significantly less than the short-term ones. ④ From the perspective of the combination of shrinking cities in different dimensions, there were a large number cities with population and economy-related shrinking cities, a small number of population and society-related shrinking cities, and no economy and society-related shrinking cities, and the number of full-dimensional shrinking cities was gradually increasing. ⑤ From the perspective of the influencing factors and driving mechanisms of urban shrinkage, traffic conditions, environmental quality, population growth, and technological innovation were the main factors that led to urban shrinkage. This study further summarized the mechanisms of core city or region adsorption, resource exhaustion, and regional adjustment. ⑥ From the perspective of coping strategies for urban shrinkage, the problems of urban shrinkage should be flexibly dealt with according to smart urban contraction, revival-oriented urbanization, and resilient urban construction. [ABSTRACT FROM AUTHOR]

In order to solve the problem of high temperature gradient near the construction joints in the step-by-step construction process of concrete engineering, an integrated cooling water pipe crack control technology based on step-by-step casting was proposed based on the traditional cooling water pipe, and the influence of the technology on the internal temperature of concrete was studied by embedding temperature measuring points. The results show that in the process of "twostep" concrete temperature rising, the temperature of "one-step" concrete can be raised evenly and synchronously with the integrated cooling water pipe crack control technology, which strengthens the uniformity of temperature change of step-by-step casting of concrete. It can significantly reduce the temperature difference on both sides of the of construction joints, improve the uniformity of temperature, and significantly reduce the number, width and length of cracks. [ABSTRACT FROM AUTHOR]

The current situation of pancreatic cancer is that the etiology is not clear and prevention is difficult. The sensitivity and specificity of the auxiliary detection method are low, and early diagnosis is a worldwide problem. The efficacy of existing treatment method is not satisfied and is difficult to break through in a short time. The 5-year overall survival rate is only 7.2%. In face of the current situation of pancreatic cancer, the key solution is to strengthen basic research, explore its etiology and pathogenesis, prevent carcinogenesis and development. Developments of the efficacy of peripheral blood and urine detection technology, imaging diagnosis technology are the critical manners to improve the early diagnosis rate. However, the research on basic and early diagnosis techniques takes a long time and costs a lot, which makes it difficult to achieve result in a short time. Therefore, the problem to be solved urgently is to develop a personalized treatment plan through standardized multi-disciplinary treatment (MDT), optimized combination of existing diagnosis and treatment methods, which may achieve the purpose of improving efficacy. This expert consensus is developed from the first edition, which is based on the diagnosis and treatment status of pancreatic cancer and the dilemma that is difficult to break through in a short time, with reference to the successful diagnosis and treatment experience at home and abroad, combined with the national condition of our country, repeated deliberation, discussion and revision by many domestic well-known experts. This consensus discusses the meaning and purpose, the main tasks, the necessary objective conditions for carrying out, workflows, precautions, relevant clinical and basic research of MDT, explorations of multi-center MDT mode and internet MDT (eMDT) mode in detail. Through the formulation and publication of this consensus, we hope that it can promote the development of standardized pancreatic cancer MDT and improve the therapeutic efficacy of pancreatic cancer in China, summarize successful experience and promote international exchanges, strengthen personnel training and echelon construction, formulate relevant policy and promote the development of MDT in the whole country. This is an expert consensus on the MDT model developed in China, which is not only applied to pancreatic cancer, but also can be used as a reference for other tumors. [ABSTRACT FROM AUTHOR]

Northeast China is a classic weakening area and becomes a difficult region of land development and high-quality development for the social-economic-ecological system. Its revitalization has the key supporting significance for the realization of the regional coordinated development in China. Based on the review on the evolution of the revitalization strategy of Northeast China and its experiences, this paper analyzes the current problems of Northeast China from the perspectives of the business environment, technological innovation, resources outflow, etc. And, the new situation and key relationship for the future revitalization of Northeast China are discussed. Then, we propose the whole thinking of revitalization development of Northeast China and design the strategical path from the perspectives of ecological protection, spatial development, and economic structure adjustment. [ABSTRACT FROM AUTHOR]

Objective To investigate the prognostic values of three different staging schemes including the number of lymph node metastasis ( N stage), lymph node ratio ( LNR) and log odd of positive lymph nodes ( LODDS) in pancreatic cancer patients after RO resection. Methods The clinical and pathological data of 307 pm1ereatic cm1eer patients who 1mderwent RO resection at Cancer Hospital of Chinese Academy of Medical Sciences from January 2010 to December 2018 were retrospectively analyzed. Kaplan-Meier and Cox propm1ional hazard regression models were used to analyze the indepedent prognostic factors. The area under the receiver operator characteristic curve ( A UC) was used to compare the prognostic efficacy of different lymph node staging systems. Results The median survival was 24. 0 months, I-year, 3-year and 5-year- survival rates were 72.0%,, 35.5% and 24.0%, respectively. Multivariate analysis showed that CA 199, differentiation, T stage, adjuvant therapy, N stage, LNR stage, and LODDS stage were independent prognostic factors for pancreatic cancer patients after RO resection (P<0.05). The A.UC values of the I-year survival rate for N stage, LNR stage, and LODDS stage were 0.591, 0.592 and 0.609, respectively. The A.UC values of the 3-ycar survival rate for N stage, LNR stage, and LODDS stage were 0.585, 0.588 and 0.593, respectively. The AUC values of the 5-ye,u- survival rate for N stage, LNR stage,,md LODDS stage were 0.554, 0.557 and 0.589, respectively. The AUC values of the LODDS stage were the highest while the N stage were the lowest, but there was no significant difference among these three systems (P>0. 05). For all patients, the LODDS staging system was slightly better than the N and LNR staging systems, but the difference was not statistically significant ( P > 0. 05). For patients with NO stage, the LODDS staging system showed better prediction performance than the N stage and LNR staging systems ( P< 0.05). Conclusions The N stage, LNR stage,,md LODDS stage arc independent prognostic factors for pancreatic cancer patients after R0 resection. For patients without lymph node metastasis., LODDS staging system is superior to N and LNR staging systems in predicting prognosis. [ABSTRACT FROM AUTHOR]

In view of technical requirements for rapid construction of concrete in marine environment, an experimental study on the performance of concrete for rapid construction of offshore engineering was carried. The workability, strength and durability of concrete were tested by using ordinary portland cement, high iron sulphoaluminate cement, high aluminum sulphoaluminate cement, high strength sulphoaluminate cement and additives. Experimental results show that sulphoaluminate cement has higher early strength than ordinary portland cement and high aluminum sulphoaluminate cement concrete has good workability, strength and durability. Its electric flux and diffusion coefficient are small and the durability of chloride resistance is better than that of high iron sulphoaluminate cement and high strength sulphoaluminate. High aluminum sulphoaluminate cement has high resistance to chloride attack and it can meet the requirements of high durability and rapid construction in the marine environment. [ABSTRACT FROM AUTHOR]