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The Party Central Committee has placed a high priority on the preservation and transfer of cultural heritage in recent years. To this end, the Committee has released several significant documents, including Opinions on the Implementation of the Project for the Inheritance and Development of Excellent Traditional Chinese Culture, which clearly outline the goals and objectives of the preservation of intangible cultural heritage and are extremely significant both historically and practically. The national intangible cultural heritage list has gradually added many areas of the blue calico printing and dyeing procedures. It is discovered that there is some literature on blue calico, but there are not many in-depth discussions of the topic. The research angle on blue calico is primarily concentrated on its creative design and application, as well as its in a particular area. The term “comprehensive discussion” refers to the fact that all blue calico is included in the summary rather than being restricted to a specific area, and there is a dearth of literature that analyzes the data and text that have been transformed into pictures, graphs, charts, and diagrams from the standpoint of visualization. Therefore, it is very crucial to create a knowledge map and visualization analysis of the blue calico to comprehend the development state, identify research hotspots, and forecast the future development trend of the blue calico. Professor Chen Chaomei of the Drexel University in the United States created CiteSpace, a Java application for information visualization that has been widely used in a variety of fields. Its features include a good visualization effect, a large amount of information provided, simple operation, etc. To analyze the literature in the field of blue calico in terms of publications, authors and collaboration, source journals and institutions, keyword clustering mapping, and bursts, the paper chose journal articles and dissertations from the CNKI database. The paper then used CiteSpace visualization software to analyze the literature and provide a summary of the research content on China’s blue calico over the previous 23 years. Data support for the development of new research directions can be obtained through data visualization and analysis of the existing blue calico research literature from multiple dimensions scientifically and systematically, and understanding the current status and hot trends of blue calico research from a macroscopic point of view. It is discovered that: there are very few complete works on blue calico, and the research varies greatly by location; colleges and universities are the primary sources of literature research institutions, with the majority of them being collaborations between the same institution and department; the design of patterns or motifs, protection and inheritance, and innovation and development are the keywords that are concentrated in these areas; the literature research has undergone three phases: the period of exploration, the period of development, and the period of innovation and inheritance; and improving product design, cultural and creative products, printing, and dyeing direction is going to be a major trend in the future. The legacy of blue calico must adapt to the current circumstances while providing effective protection. Achieving a balance between inventive progress and inheritance requires the integration of current technology and digital communication while maintaining the use of natural raw materials, traditional techniques, and inherited pattern styles. [ABSTRACT FROM AUTHOR]

In order to study the effects of different density and row spacing on agronomic traits and yield of spring maize in this area,Shaandan 650 and Dafeng 30 were used as test varieties. Set up 2 lines 1 belt 40 cm + 80 cm (A), 3 lines 1 belt 40 cm + 40 cm + 120 cm (B), 3 lines 1 belt 60 cm + 60 cm + 120 cm (C), 4 lines 1 belt 40 cm +40 cm+40 cm plus 120c m (D), 4 lines 1 with 60 cm + 60 cm + 60 cm plus 120 cm wide-narrow row and control 60 cm equal row spacing (F) 6 row spacing configuration mode,two planting densities of 67 500 and 90 000 plants/hm²are set. The experimental design of the split plot of three factors was adopted, with the planting mode as the main area and the variety and density as the secondary zone, to explore the differences in agronomic traits and yield of maize under different row spacing configurations. The results showed that for the same variety, the plant height and ear height increased with the increase of density, while the stem diameter decreased with the increase of density. The plant height and ear height of the treatment of 3 rows and 1 belt (60 cm+60 cm+120 cm) were significantly higher than those of the other row spacings, the stem diameter is the opposite. Maize grain yield increased with the increase of density. The yield of 6 000 plants/hm²was obviously higher than that of 67 500 plants/hm²under the same planting pattern of the same variety. Ear diameter, ear length, row number per ear, grain number per row and 100-grain weight decreased with the increase of planting density, while bald tip length increased with the increase of planting density. The highest yield planting mode of Shaandan 650 is as follows: Under the density of 90 000 plants/hm², the yield was 18 504. 15 kg /hm²with 3 rows and one row spacing (40 cm+40 cm+120 cm); the second is 3 rows and 1 strip (60 cm+60 cm+120 cm) row spacing under the density of 90 000 plants/hm², the yield is 17 768. 55 kg /hm²;the highest yield of Dafeng 30 was 19 421. 40 kg /hm²under the planting density of 90 000 plants/hm²with 3 rows and 1 belt (60 cm+60 cm+120 cm). [ABSTRACT FROM AUTHOR]

[Objective]Cyprinus multitaeniata is one of the important economic fish in China. Understanding the structure and characteristics of complete mitogenome of Cyprinus multitaeniata, to provide a scientific basis for the protection and utilization of its germplasm resources. [Method]In this study, 26 pairs of primers were used to amplify the complete mitochondrial gene of C. multitaeniata. The position and characteristics of each gene and non-coding sequences were identified and analyzed by softwares. The sequence of C. multitaeniata was compared with the published sequences of Cyprinidae in GeneBank database and the phylogenetic tree was constructed. [Result]The total length of mitogenome of C. multitaeniata was 16 573 bp, and the base contents of A, T, C, and G were 32. 2%, 24. 9%, 27. 3%, and 15. 6%, respectively. There were 37 coding genes (22 tRNA genes, 13 coding protein genes, and 2 rRNA genes) and 2 noncoding sequence regions (OL and control regions) in the complete mitogenome C. multitaeniata. The start codon of 13 protein coding genes was ATG except for COX1 which was GTG. Stop codons included TAG (ATP8), TA (COX3, ATP6), T (ND2, COX2, ND3, ND4, Cty b) and TAA (ND1, COX1, ND4L, ND5, ND6). All the 22 tRNA genes except tRNASer (AGC) folded into the typical clover structure. Three typically conserved regions could be identified in the control region of C. multitaeniata. Phylogenetic analysis showed that the C. multitaeniata was closely related to the C. megalophthalmus. [Conclusion]The composition, length, and sequence of mitochondrial genes of C. multitaeniata were similar to those of typical vertebrates, and it is the closest to C. megalophthalmus in genetic relationship. The mitochondrial genome sequence is suitable for phylogenetic analysis of the C. multitaeniata. [ABSTRACT FROM AUTHOR]

Aflatoxin contamination in feed has seriously restricted the high-quality development of the feed industry and animal husbandry. Under the current comprehensive ban on antibiotics in feed in China, natural plant materials are highly regarded as ideal antibiotic substitutes. Eucommia ulmoides Oliv. is a traditional medicinal and edible plant resource in China. Its extract or raw powder added to feed can effectively contain aflatoxin contamination and improve the quality of livestock and poultry, making it an ideal feed substitute for antibiotics. In this paper, the inhibitory effect of E. ulmoides extract and its active ingredients on A. flavus and its beneficial effects in animal husbandry, aiming to provide reference for its application and promotion in the animal husbandry. [ABSTRACT FROM AUTHOR]

Objective: To explore the efficacy and mechanism of taohong siwu decoction on promoting fracture healing after proximal femoral nail antirotation（PFNA） in elderly patients with fntertrochanteric fracture based on phosphatidylinositol 3-kinase（PI3K）/serine protein kinase（Akt） signaling pathway. Methods: 90 elderly patients with fntertrochanteric fracture treated with PFNA who were admitted to Suining Hospital of Traditional Chinese Medicine from July 2021 to December 2022 were selected, patients were divided into control group and study group according to the random number table method, 45 cases each. Control group received routine intervention after operation, and study group received taohong siwu decoction on the basis of control group. The traditional Chinese medicine syndrome scores, fracture healing time, Harris hip function scores, hemorheology, PI3K/Akt signaling pathway related indicators were compared between two groups. Results: The hip pain, pain, fatigue, limb weakness, dizziness, insomnia, forgetfulness, spontaneous sweating,fear of wind and cold, chest tightness, shortness of breath, skin nails, pale complexion score and total score in study group were lower than those in control group after treatment（P＜0.05). The fracture healing time in study group was shorter than that in control group, Harris hip function score was higher than that of control group（P＜0.05). The hematocrit, plasma specific viscosity, whole blood specific viscosity and erythrocyte electrophoresis time in study group were lower than those in control group（P＜0.05). PI3K m RNA and Akt m RNA in study group were higher than those in control group after treatment（P＜0.05). Conclusion: Elderly patients with fntertrochanteric fracture are treat with taohong siwu decoction after PFNA surgery, which can promote the clinical prognosis of patients, reduce traditional Chinese medicine syndrome scores, promote the recovery of hip joint function, shorten the healing time of fractures, improve hemorheology of the body, and regulate the expression of PI3K/Akt signaling pathway. [ABSTRACT FROM AUTHOR]

Severe fever with thrombocytopenia syndrome (SFTS) and hemorrhagic fever with renal syndrome (HFRS) are infectious diseases. The epidemic of these two diseases can seriously affect human life and health, and is also a public health problem currently facing in the world. Due to the uneven level of medical development around the world, many doctors have insufficient understanding of these two diseases, which is likely to lead to missed diagnosis or misdiagnosis, and the patients are not treated correctly, which leads to aggravation of the disease and affects their prognosis. Clinically, the diagnosis of SFTS and HFRS mainly depends on the results of pathogenic examination and serological examination, but many medical institutions have not carried out these two examinations. Therefore, if epidemiological and clinical characteristics can be used to diagnose and differentiate these two diseases, it will help guide clinical practice. This paper reviews the research progress in the diagnosis and differential diagnosis of SFTS and HFRS at home and abroad in recent years. [ABSTRACT FROM AUTHOR]

At present, scholars at home and abroad mostly focus on the traditional swing pump, while the research on the structural design of the brand-new swing pump is relatively few.The new swing pump has complex structure and large flow pulsation. Therefore, based on the principle of variable aperture of iris mechanism, a new swing pump model with simple structure was proposed, and the kinematics analysis and internal flow field research of the new swing pump were carried out. Firstly, the working principle of the new swing pump was analyzed, the geometric model of the new swing pump was established, and the displacement, velocity and corresponding instantaneous flow equation of the iris mechanism were derived. Then, ICEM CFD software was used to mesh the new swing pump, and the fluid region of the new swing pump was numerically simulated by using the dynamic mesh technology of Fluent software and RNG k-ε turbulence model. Finally, the pressure distribution cloud diagram, velocity distribution cloud diagram and flow pulsation curve of the internal flow field of the new swing pump were obtained by numerical simulation. The correctness of the kinematics equation was verified by comparing the flow pulsation curve. The results show that the structural design of the new swing pump is effective, and the maximum instantaneous flow rate is 1 387.2 L/min, which meets the design requirements. At the same time, the pressure inside the new swing pump chamber is mainly concentrated in the aperture position surrounded by the iris mechanism, and the maximum pressure value is 0.45 MPa. The maximum flow velocity inside the cavity is mainly concentrated at the oil outlet and the oil inlet, and the maximum flow velocity can reach 62 m/s. The velocity curve and the flow pulsation curve have the same waveform. The new swing pump enriches the structure of the pump and provides a reference for the future research of this type of pump. [ABSTRACT FROM AUTHOR]

Faced with the high-quality demand for low-carbon and green development, we need to know if the construction of an intellectual property system (CIPS) can be a covert force to restrain the industrial pollution of Chinese cities. This paper regarded the establishment of intellectual property demonstration cities as a quasi-natural experiment. Based on explaining the impact mechanisms of CIPS on industrial emissions, this study adopted the panel data of 108 cities in the Yangtze River Economic Belt from 2003 to 2019 and empirically tested the emission reduction effect of CIPS and its mechanisms by using the difference-in-differences (DID) method. The heterogeneity, dynamic effects, and spatial spillover effects were also explored. The results showed that: ① At the urban level of the Yangtze River Economic Belt, the CIPS significantly reduced industrial pollution emissions, and the emission reduction effect kept in‑ creasing. This conclusion was still valid under a series of robustness tests, such as continuous DID and instrumental variable methods (IV). ② Heterogeneity analysis showed that the CIPS had good emission reduction performance in the upper, middle, and lower reaches of the Yangtze River and large and medium-sized cities, and the emission reduction effect was better in the upper reaches of the Yangtze River and large cities. The CIPS had more obvious inhibitory effects on water pollution and gas pollution than on soot pollution. ③ Spatial spillover effect analysis showed that the CIPS restrained the industrial pollution of the demonstration cities and their neigh‑ boring cities, the policy effect showed spatial spillover, and the indirect effect was greater than the direct effect. ④ Mechanism analysis showed that the CIPS could lead to urban industrial upgrading and allocation optimization through technological innovation, indirectly inhibit industrial pollution emissions, and directly promote industrial pollution control through green innovation. Based on this, this pa‑ per proposes to promote the CIPS, explore and implement differentiated intellectual property governance policies, and strengthen ex‑ changes and cooperation on intellectual property among cities, in order to drive the high-quality development of the Yangtze River Economic Belt through innovation. [ABSTRACT FROM AUTHOR]

As the geological environment of the diversion tunnel is changeable, and shield construction is a complex construction process, the risk probability is high, the risk is difficult to predict, and the economic loss and personal injury caused by the risk are immeasurable. Looking for and analyzing the possible risk sources in shield construction of diversion tunnel is helpful to ensure the safe construction of tunnel engineering. In this paper, for a diversion tunnel, the WBS-RBS method was used to build a risk matrix, identify the risk sources of tunnel shield construction through the study of the matrix, and then determined the weight of each risk factor of the tunnel through the Analytic Hierarchy Process, obtained the impact degree of each risk factor on the progress of tunnel shield construction, and formulated corresponding risk control measures according to the impact degree, so as to provide effective management methods for tunnel shield construction. It made the safety management of tunnel shield construction from post remediation to pre prevention, reduced the probability of risk occurrence, and improved the level of safety management of tunnel shield construction. [ABSTRACT FROM AUTHOR]

Objective To explore whether the influence of isoliquiritigenin on osteoblast differentiation in osteoporosis（OP） rats is related to the regulation of receptor activator of nuclear factor-κB ligand（RANKL）/receptor activator of nuclear factor-κB（RANK）/tumor necrosis factor receptor-associated factor 6（TRAF6） signaling pathway. Methods The postmenopausal OP rat model was established by castration. After 2 weeks of modeling, the rats were randomly grouped into model group, positive group（estradiol valerate 0.09 mg/kg）, and low dose（10 mg/kg）, medium dose（20 mg/kg） and high dose（40 mg/kg） isoliquiritigenin groups, with 10 rats per group, and another 10 rats were taken as the sham operation group. After the administration, ELISA method was applied to detect the levels of alkaline phosphatase（ALP） and estradiol（E2） in rat serum; Micro-CT was applied to scan and observe bone microstructure indicators; HE staining was applied to observe the histopathology of the femur; immunohistochemistry was applied to detect the expression of Runt-related transcription factor 2（Runx2） protein in rat femur; Western Blot was applied to detect the protein expression of RANKL, RANK and TRAF6 in rat femur. Results Compared with the model group, the bone tissue lesions of the rats in the positive group and the isoliquiritigenin groups were reduced, and new bone trabeculae could be seen; the levels of ALP [（107.94±9.83） U/L,（75.27±7.51） U/L,（89.35±9.14） U/L,（106.33±10.02） U/L vs（53.79±5.62） U/L] and E2 [（27.71±2.67） pg/mL,（18.36±1.82） pg/mL,（23.65±2.28） pg/mL,（27.46±2.71） pg/mL vs（14.64±1.59） pg/mL], the Tb.Th [（0.36±0.04） mm,（0.23±0.02） mm,（0.28±0.03） mm,（0.36±0.03） mm vs（0.12±0.01） mm], Tb.N [（4.45±0.44） 1/mm,（2.67±0.27） 1/mm,（3.36±0.34） 1/mm,（4.41±0.44） 1/mm vs（1.51±0.12） 1/mm], BMD [（0.37±0.04） g/cm²,（0.22±0.02） g/cm²,（0.29±0.03） g/cm²,（0.38±0.03） g/cm² vs（0.14±0.01） g/cm²], BV/TV [（11.94±1.23） %,（7.12±0.70） %,（8.49±0.85） %,（11.77±1.16） % vs（5.75±0.61） %] and the expression of Runx2 [（0.84±0.08）,（0.41±0.04）,（0.59±0.06）,（0.82±0.08） vs（0.27±0.03）] were increased（P＜0.05）, while the Tb.Sp [（0.25±0.02） mm,（0.43±0.04） mm,（0.34±0.03） mm,（0.23±0.02） mm vs（0.56±0.06） mm] and the expressions of RANKL [（0.42±0.04）,（0.86±0.08）,（0.64±0.06）,（0.45±0.04） vs（1.09±0.11）], RANK [（0.39±0.04）,（0.81±0.08）,（0.67±0.06）,（0.41±0.04） vs（1.03±0.10）], TRAF6 [（0.47±0.05）,（0.77±0.08）,（0.61±0.06）,（0.49±0.05） vs（0.96±0.09）] proteins were decreased（P＜0.05）, and isoliquiritigenin is dose-dependent. Conclusion Isoliquiritigenin may promote the differentiation of osteoblasts and improve femoral lesions by inhibiting the RANKL/RANK/TRAF6 signaling pathway, thus exerting an effective therapeutic effect on OP. [ABSTRACT FROM AUTHOR]

OBJECTIVE: Cold water immersion methods are not standardized in terms of operational indicators such as immersion temperature, duration and depth, leading to controversy over the efficacy of recovery from exercise fatigue in skeletal muscle. In this article, we analyze the effects of cold water immersion on muscle injury, muscle soreness and muscle strength recovery under different factors, in order to find the best immersion implementation plan, and thus provide evidence for the recovery of muscle fatigue. METHODS: A search of CNKI, WanFang Data, Web of Science, and PubMed databases was conducted for relevant literature published from January 1, 2000 to August 15, 2023. A total of 4 759 articles were initially retrieved, with 4 735 articles excluded through screening and 24 articles finally included. The Physical Therapy Evidence Database Scale was used to assess the methodological quality of the included literature, and Stata-MP 16 software was used to perform effect size combinations, subgroup analyses, Meta-regression, sensitivity tests, and publication bias analyses. RESULTS: (1) The article included a total of 24 randomized controlled trial studies, including 617 subjects, with overall high legal quality. (2) Meta-analysis showed that cold water immersion can significantly reduce creatine kinase blood value [standardized mean difference (SMD)=-0.17, 95% confidence interval (CI): -0.29 to -0.05, P < 0.01], alleviate muscle pain (SMD=-0.60, 95% CI: -0.81 to -0.38, P < 0.01), and promote maximum muscle strength recovery (SMD=0.17, 95% CI: 0.05 to 0.30, P < 0.01). (3) Subgroup analysis showed that: The immersing regimen with water temperature > 14 °C (SMD=-0.48, 95% CI: -0.76 to -0.20, P < 0.01) and duration of 12-14 minutes (SMD=-0.38, 95% CI: -0.61 to -0.15, P < 0.01) had the best effect in reducing creatine kinase blood values, and had a more significant intervention effect on endurance exercise (SMD=-0.45, 95% CI: -0.71 to -0.20, P < 0.01), while the immersion regimen with water temperature < 10 °C (SMD=-0.61, 95% CI: -0.79 to -0.43, P < 0.01), duration < 12 minutes (SMD=-0.76, 95% CI: -0.98 to -0.53, P < 0.01), and immersion depth above the iliac spine (SMD=-0.74, 95% CI: -0.97 to -0.52, P < 0.01) had the best effect on relieving muscle soreness, and had a more significant analgesic effect after endurance exercise (SMD=-0.42, 95% CI: -0.61 to -0.22, P < 0.01). (4) Meta regression showed that immersion water temperature, immersion duration, and exercise type were important regulatory factors affecting the effect size of creatine kinase; immersing water temperature and immersing depth were important regulatory factors affecting the effect size of visual analogue scale score, while exercise type was an important regulatory factor affecting the maximum isometric muscle strength effect size. CONCLUSION: (1) Evidence of extremely low to moderate strength suggests that cold water immersion can effectively reduce muscle damage, alleviate muscle soreness, and promote muscle strength recovery. (2) In terms of reducing muscle injury, immersion water temperature, immersion duration, and exercise type are significant regulatory factors that affect the efficacy of immersing. Among them, immersion water temperature > 14 °C and duration of 12-14 minutes are the best solutions to reduce muscle injury after exercise, and the immersing effect is better for endurance exercise. (3) In terms of reducing muscle soreness, immersion water temperature and immersion depth are important regulatory factors that affect the intervention effect. Among them, immersion water temperature < 10 °C, duration < 12 minutes, and immersing depth above the iliac spine are the best solutions to reduce muscle soreness, and have a better analgesic effect after endurance exercise. (4) In terms of promoting muscle strength recovery, exercise type is a key regulatory factor that affects the maximum isometric muscle strength effect. [ABSTRACT FROM AUTHOR]

The body of the armored vehicles, as a large box-type load-bearing structure, not only has to bear various loads, but also has a certain protection ability. It is a complex load-bearing system. The body is an important carrier in the whole life cycle of the armored vehicle. The structural design of the body and the analysis of the test mode have an important impact on the performance and reliability of the armored vehicle. In order to obtain the dynamic characteristic parameters of an amphibious vehicle body and verify its structural rationality, a new material amphibious vehicle body was taken as the research object, and computational modal and experimental modal analysis respectively were carried out. The reliability of the finite element model was verified by the comparative analysis of the modal parameters of the body and the test modal results. Based on the modal distribution of the body structure of the amphibious vehicle, the rationality of the body structure design was analyzed, which could avoid the occurrence of most low-order modal couplings. At the same time, in order to avoid the resonance generated in the vehicle maneuvering, the matching design of the external excitation sources such as the suspension device is put forward, which provides a theoretical basis for the optimal design of the body structure of an amphibious vehicle and the improvement of the dynamic response characteristics of the vehicle. [ABSTRACT FROM AUTHOR]

Due to the difficulty of obtaining data from few radiation sites and the low applicability of existing surface radiation estimation models in Yunnan Province, a high-precision solar radiation estimation model suitable for Yunnan Province needs to be explored. A multi-factor comprehensive estimation model(MFCE) applicable to Yunnan Province was constructed by using meteorological and remote sensing data to screen out 7 factors such as altitude and sunshine percentage, and the accuracy of parameters and calculation results in the model were calculated month by month. The correlation coefficients of the MFCE model were above 0. 7 for each month, which increase 0. 3 on average compared with other models. The root mean square error distribution is between 16. 21 and 33. 73 MJ/ m², which decrease compared with other models. The estimation results and accuracy of the MFCE model are greatly improved compared with the traditional models, and the proposed model provides help and scientific basis for the study of solar radiation in Yunnan Province and the rational use of solar energy. [ABSTRACT FROM AUTHOR]

When the daily average water temperature exceeds 32℃, the hatching rate and feeding rate of some warm water fish decrease with the increase of temperature, grow slowly or stop growing, and are easy to induce diseases. In summer, the water temperature in the fish pond is not always in the high temperature period. In this paper, based on the water and air temperature data of Fushun Aquaculture Meteorological Service Test Base from 2017 to 2019, the variation characteristics of water temperature in each layer of fish pond in summer were analyzed, and the prediction models of average and maximum water temperature on the sunny days were established by stepwise regression analysis. Results showed that the daily max. water temperature in each layer in summer occurs from 18:00 to 19:00, which lagged behind the temperature by 1-3 hours. The period when the water temperature ≥32℃ was mainly concentrated from 16:00 to 22:00, and the hourly average water temperature of each layer in this period was 32.9-33.1℃, 32.6-32.7℃ and 32.1-32.3℃, respectively. The water temperature of each layer fluctuated and rose with the temperature in summer, especially from mid-June to early-July, while the maximum values of temperature and water temperature appeared in late-July. The average number of days with water temperature ≥32℃ in summer was 23 days, accounting for a quarter of the whole summer, mainly from late July to mid-August. During this period, the daily average water temperature of each layer was 28.5-34.4℃, 28.2-34.1℃ and 27.9-33.9℃, respectively. The back substitution test in 2017-2018 and the forecast test in 2019 showed that the average absolute error of the model was 0.3-0.8℃, and the average relative error was within 2.6%, indicating that the model has good prediction effect and can be better applied to the prediction of fish pond water temperature in summer. [ABSTRACT FROM AUTHOR]

目的 基于人的全面发展理论, 以学生为中心, 探索护理伦理学课程思政新路径。方法 通过 充分挖掘思政元素, 创新思政教学方法, 综合评价等对护理伦理学课程思政进行设计, 采用自行设计的《护理伦 理学课程思政现状及满意度调查表》对 2022 级护理学专业 158 名学生进行调查。课程结束后, 通过理论和形 成性考核成绩, 调查表评价课程思政改革的教学效果。结果 学生对护理伦理学教学内容融入课程思政目标, 切入点, 元素和内容满意程度为 94.93%;运用角色扮演法, 启发式教学法, 小组辩论式教学法, 案例讨论式教学 法, 情景体验式等多种教学方法学生满意度为 97.47%。结论 以人的全面发展理论为视角, 探讨护理伦理学 课程思政建设路径及效果, 为专业课程思政建设路径研究和护理学专业课程思政改革拓展思路。 [ABSTRACT FROM AUTHOR]

Hybrid electrolyte lithium - air batteries have been widely studied due to their high theoretical energy density, but the oxygen reduction reaction ( ORR ) rate on the positive electrode of the battery is low, which is one of the main factors limiting the development of lithium - air batteries. This paper proposed the ruthenium (R u) doped monolayer graphene as anode catalyst for ORR. Based on the first principles, the electronic structures of n( n = 1 - 3) Ru doped graphenes were studied and the oxygen adsorption properties on these Ru doped graphene surfaces were calculated. Furthermore, the transition state ORR reaction path search method was used to study the ORR mechanism on Ru doped monolayer graphene surface in alkaline solution. The results sh ow that the graphenes doped with Ru atoms can obtain a stable structure, and the electrical conductivities are significantly improved. Compared with the original monolayer graphene, Ru doped graphenes show higher adsorption capacity toward 0 2 . The ORR on the surface of three Ru ( n = 3) doped graphene does not need to overcome any energy barrier. In addition, the adsorption energy of OH groups on the surface of three - Ru doped graphene is the lowest, which is conducive to the continuous ORR process. The results indicate that the three - Ru doped graphene is expected to be a novel ORR catalyst to improve the performance of hybrid electrolyte lithium - air batteries. [ABSTRACT FROM AUTHOR]

APT has caused great damage to enterprises and government. However, most detection methods do not take into account the two characteristics, that is temporal and spatial. The invaded host will produce temporal abnormal behaviors different from the usual. In terms of spatial,the invaded host will often continue to infiltrate other hosts. Therefore, this paper proposed the method to detect APT compromised hosts based on temporal- spatial characteristics. This method targeted the abnormal authentication behavior in APT. It constructed the host authentication graph, and extracted some important features from the graph. This method used LSTM to extract the temporal- based features of the host, built the host association graph and used G AT to obtain the spatial features and relationships between the hosts. It used neural network to extract features without manual feature selection. The method is tested on public data LANL, and the F1 score reaches 0. 979. [ABSTRACT FROM AUTHOR]

: Net carbon sink from land-use change has been one of the most important factors on the process of cultivated land use. The comprehensive zoning optimization of cultivated land use can be an effective way to realize the green and sustainable development of agriculture and improve the net carbon sink level of cultivated land use in China. A theoretical basis can also be provided for the protection of cultivated land at the national level, and the optimal allocation of cultivated land resources. In this study, the trend of net carbon sink of cultivated land use was estimated in 31 Provinces (cities and districts) in China from 2005 to 2020, particularly from the perspective of carbon source and carbon sink of cultivated land use. The dynamic evolution and interval difference were analyzed using Kernel density estimation. The decoupling effect was also established between the net carbon emission of cultivated land and agricultural economy. After that, the comprehensive zoning of cultivated land use was optimized to combine with the decoupling and characteristics in the main grain producing areas. A Grey Model (GM) was utilized to predict the change trend and decoupling status of net carbon sink in each comprehensive zoning from 2021 to 2035. The results showed that: 1) There was a fluctuating upward trend for the net carbon sink of cultivated land use, with an average annual growth rate of 3.740% in the study period. The spatial difference of carbon sink capacity was much better in the main grain producing areas, compared with the rest. 2) Kernel density estimation shows that the regional gap of net carbon sink of cultivated land use was gradually narrowing. However, there was still a regional imbalance. The main grain producing areas, the balance of production and marketing areas, and the main sales areas all showed a trend of diffusion to the high-value carbon sink areas. 3) There was the mainly strong decoupling between the net carbon emissions from the cultivated land use and agricultural economy in the study period. A comprehensive zone was achieved for the coordination of economic and ecological benefits in the most provinces (cities and districts), except for Beijing, Shanghai, Guangdong and Hainan in 2020. 4) The GM predicted that the carbon sink capacity of cultivated land use would maintain a steady growth from 2021 to 2035, and there was the strong decoupling status of each comprehensive zone. Consequently, it is very feasible for the unification of economic and ecological benefits in the future cultivated land use. The finding can also provide a strong reference and guidance for the “double carbon” goal in the field of cultivated land. Finally, the targeted optimization strategies and directions can be greatly contribute to the coordinated development of economic and ecological benefits of cultivated land use in the whole country and various comprehensive divisions, in order to achieve low-carbon, green, and high-quality development of cultivated land use. [ABSTRACT FROM AUTHOR]

BACKGROUND: According to the current clinical application of Nocardia rubra cell wall skeleton to the treatment of cervical erosion and its immune effect, considering the possibility of its treatment of chronic wounds. OBJECTIVE: To study the effect of Nocardia rubra cell wall skeleton for extemal use on the proliferation and apoptosis of adipogenic mesenchymal stem cells in vitro, and the impact on the survival rate and skin healing of adipogenic mesenchymal stem cells transplantation in vivo. METHODS: Adipogenic mesenchymal stem cells were treated with 10 mg/L Nocardia rubra cell wall skeleton for extemal use. CCK-8 and EDU kits were used to detect the viability and proliferation of adipogenic mesenchymal stem cells. Adipogenic mesenchymal stem cells were treated with 50% sucrose to induce apoptosis, and then with Nocardia rubra cell wall skeleton for extemal use. Afterwards, flow cytometry and TUNEL assay were used to detect the apoptosis. Nocardia rubra cell wall skeleton for extemal use (10 mg/L, 5 mL) was added to passage 3 adipogenic mesenchymal stem cells for 48 hours of culture. The pretreated cells labeled with the fluorescent dye CM-Dil were injected intracutaneously into the wound skin of diabetic mice. The cell survival rate was detected by the LB983 in vivo imaging system. Hematoxylin-eosin staining, Masson staining, and immunofluorescence were used to verify the healing of chronic wounds on day 14. RESULTS AND CONCLUSION: Nocardia rubra cell wall skeleton for extemal use could promote the viability and proliferation of adipogenic mesenchymal stem cells, and inhibit their apoptosis. Nocardia rubra cell wall skeleton for extemal use increased the survival rate of adipogenic mesenchymal stem cells under in vivo conditions. The wound healing rate is faster in diabetic mice. [ABSTRACT FROM AUTHOR]

Carbon ecological compensation is an effective means to coordinate regional ecological protection, promote economic development and achieve carbon neutrality. In order to build a diversified ecological compensation mechanism, promote the low-carbon transformation of the basin and achieve the goal of carbon neutrality in the Yellow River Basin, this paper took 9 provinces （regions） along the Yellow River as the research area, combined carbon neutrality targets with ecological compensation mechanisms and constructed a theoretical framework model of carbon ecological compensation. Based on carbon emissions and carbon sinks, the subject and object of carbon compensation were determined and supplementary example was used to explore the temporal and spatial evolution characteristics of carbon ecological compensation in the Yellow River Basin from 2007 to 2017. The results show that the regional heterogeneity of carbon compensation credits in the 9 provinces （regions） along the Yellow River, affected by the level of economic and social development, resources endowments, carbon resources use efficiency, willingness to pay and ability is relatively larger in terms of the temporal and spatial pattern. Except for Ningxia, Qinghai, Sichuan, Gansu and Inner Mongolia in the upper and middle reaches of the Yellow River contribute more to carbon emission reduction and sequestration and they are carbon compensated areas. The middle and lower reaches of Shaanxi, Shanxi, Henan and Shandong are carbon payment areas. The carbon deficit of Shanxi and Shandong is significantly higher than that of other provinces and the improvement of the ecological environment has a certain degree of lag. It is urgent to transform the economic development model to improve the matching degree of regional carbon emissions and resources endowment characteristics. Based on the results, policy recommendations for the construction of low-carbon transition and diversified ecological compensation mechanism in the Yellow River Basin are condensed. [ABSTRACT FROM AUTHOR]

Objective: To investigate the feasibility of the whole bone marrow attachment method to isolate and culture SD rat bone marrow mesenchymal stem cells in vitro, study their biological characteristics, and provide seed cells for bone tissue engineering. Methods: Two healthy SD rats aged 5 weeks with SPF grade were sacrificed by neck dissection. Femur and tibia of lower limbs were isolated, and BMSCs were cultured and purified by whole bone marrow adherent method. The growth of primary and passage cells was observed by inverted microscope, the growth and adherent rate curves were plotted to study their biological characteristics, and the surface markers, fat induction and bone formation were identified by flow cytometry. Results: BMSCs with good activity and high purity could be isolated by whole bone marrow adherent method in vitro. Under inverted microscope, the primary cells showed long spindle shape, short spindle shape and polygon shape, and the morphology of the passage cells was uniform and fibro-like. BMSCs were identified by flow cytometry: CD44 and CD90 were highly expressed, while CD31 and CD45 were low. The differentiation of osteoblasts was induced, and mineralized nodules were visible. Conclusion: BMSCs can be successfully isolated by whole bone marrow adherent culture method in vitro. The isolated, cultured and purified BMSCs are biologically stable, with high purity, good activity and multidirectional differentiation potential, which can provide seed cells for bone tissue engineering research. [ABSTRACT FROM AUTHOR]

In view of the concentration of measurement points in the traditional sensor optimization method with a large number of configurations,the relationship between optimization results and prediction errors was analyzed based on the information entropy theory,and an improved optimization method considering prediction errors was proposed. The reciprocal of the sum of normalized modal strain energy was used as the principal diagonal element of the prediction error covariance matrix,and the non-diagonal element was expressed by an exponential correlation equation combining the distance of measurement points and the response level. Aiming at maximizing the determinant of Fisher information matrix,the forward sequential sensor placement method was used to obtain the optimal location of measurement points. The finite element analysis results of the urban rail vehicle frames showed that the improved sensor optimization method is superior to the classical method in the performance of three evaluation criteria,and significantly reduces the concentrating effect of measurement points,which proves the effectiveness of the improved method in the configuration of bogie frame strain sensors. [ABSTRACT FROM AUTHOR]

To solve the problem that, ICP algorithm has a single feature for searching and low accuracy for registration, this paper proposed a point cloud registration algorithm based on multiple-feature matching. It chose the improved adaptive octree algorithm to segment the point cloud. Then it calculated the multiple features of the points after the local fitting of the leaf nodes by MLS algorithm. Next, this algorithm introduced the point pairs similarity based on multiple-feature to establish the matching points. Lastly, it computed the rotation matrix and translation matrix to achieve registration. Experiments show that this algorithm can effectively improve the accuracy of registration on the basis of keeping the point cloud registration speed high. And with the number of point sets increasing, the trend of accuracy for this method is increasing. [ABSTRACT FROM AUTHOR]

Objective To investigate the characteristics of flora microbiota before and after transjugular intrahepatic portosystemic shunt (TIPS) in patients with liver cirrhosis. Methods A total of 18 patients with liver cirrhosis who were hospitalized and underwent TIPS in Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, from July 2018 to July 2019 were enrolled. Fecal samples were collected from 18 patients before surgery, 6 fecal samples were collected at 1 month after surgery, and 9 were collected at 3 months after surgery. The results of liver function and coagulation were collected before and after surgery. Fecal samples were analyzed by the 16S rRNA high-throughput sequencing method, and the DADA2 method recommended by QIIME2 was used in the bioinformatics analysis. The intestinal flora was analyzed in terms of the generated amplified characteristic sequence, and the multiple hypothesis tests of LEfSe, SPSS (Alpha analysis), PERMANOVA (Beta analysis), and Pheatmap were used for analysis. For normally distributed continuous data, intergroup comparison of parameters at different time points was made by a repeated measures analysis of variance. For non-normally distributed continuous data, intergroup comparison of parameters at different time points was made using a generalized estimating equation, and further pairwise comparison was made using the Bonferroni method. Results There were significant differences in total bilirubin and total bile acid between groups before TIPS and during the three periods of time after TIPS (F=8.201 and 39.482, P=0.001 and P＜0.001). At 1 month after surgery, Beta diversity changes were observed in fecal samples (F=2.603, P=0.02), while there was no significant difference in Alpha diversity of the fecal samples between the three periods of time (P＞0.05). At the genus level, portal venous pressure before TIPS was negatively correlated with Bifidobacterium, Collinsella, and Ruminococcus (r=-0.35, -0.38, and -0.34, P=0.04, 0.02, and 0.04) and was positively correlated with Boletus (r=0.41, P=0.015). Other indices were also correlated with different components of the intestinal flora (P＜0.05). Conclusion There is a correlation between clinical indices and intestinal flora before TIPS. The composition of intestinal flora changes after TIPS, with a significant difference at the genus level. [ABSTRACT FROM AUTHOR]

BACKGROUND: Bone morphogenetic protein 2 (BMP-2) and vascular endothelial growth factor 165 (VEGF-165) play important roles in bone repair. It is of great significance to treat bone injury by lentivirus-transfected bone marrow mesenchymal stem cells combined with demineralized bone matrix. OBJECTIVE: To observe the therapeutic effects of bone marrow mesenchymal stem cells with lentivirus-mediated BMP-2 and VEGF-165 co-transfection and demineralized bone matrix in a rabbit model of osteonecrosis of the femoral head, so as to explore the feasibility of dual genes in the bone repair. METHODS: Femoral head necrosis model was prepared by liquid nitrogen freezing combined with core decompression. Rabbit models successfully prepared were divided into three groups (n=12/group): non-transfection group, treated with bone marrow mesenchymal stem cells combined with demineralized bone matrix; single gene transfection group, treated with BMP-2-transfected bone marrow mesenchymal stem cells combined with demineralized bone matrix; dual-gene transfection group, treated with BMP-2 and VEGF-165 co-transfected bone marrow mesenchymal stem cells combined with demineralized bone matrix. Four rabbits from each group were sacrificed at 3, 6, and 9 weeks postoperatively. Western blot was used to detect the expression of BMP-2 protein in the femoral head of each group. Hematoxylin-eosin staining was used to observe the repair of femoral head necrosis in each group. The study protocol was approved by the Animal Ethics Committee of Guilin Medical University. RESULTS AND CONCLUSION: BMP-2 positively expressed in all groups at 3, 6, and 9 weeks postoperatively, and the positive expression of target protein was significantly higher in the two transfection groups than the non-transfection group (P < 0.05). The positive expression of BMP-2 in the two transfection groups showed an increasing trend at three time periods. At 3 weeks postoperatively, there was no difference in the BMP-2 expression between the two transfection groups, while the BMP-2 expression was significantly increased in the dual-gene transfection group compared with the single gene transfection group at 6 and 9 weeks postoperatively (P > 0.05). In the dual gene transfection group, new osteophytes could fill in the defect of the femoral head at 9 weeks postoperatively, while in the other two groups, new osteophytes formed were not enough to fill in the defect. Hematoxylin-eosin staining indicated that primary trabeculae were formed in the non-transfection group, but there were more necrotic cells and less bone trabeculae. In the single gene transfection group, a large amount of trabeculae formed with good shape, some of which however were inferior to normal bone tissues because of fractures. In the dual gene transfection group, a mass of mature and dense trabeculae were formed and had normal shape. To conclude, lentivirus-mediated BMP-2 and VEGF-165 co-transfection is superior to single BMP-2 transfection in the combination of bone marrow mesenchymal stem cells and demineralized bone matrix for treating femoral head necrosis. Moreover, in vivo expression of target protein persists for a long time. [ABSTRACT FROM AUTHOR]

With the expansion of the fields of mobile robot applications and the complication of its working environment, traditional path planning algorithms become difficult to meet people' s requirements due to their own limitations. In recent years, bioinspired intelligent algorithms ( BIAs) are widely used in mobile robot path planning optimization because of its collective intelligence of the group and the characteristics of biological preference . First, this paper classified the bioinspired intelligent algorithms used in the path planning optimization according to their sources of the biomimetic mechanism. Then, to optimize the latest research results and summarize existing problems and solutions, it described systematically various new bioinspired intelligent algorithms used in the path planning optimization according to different categories, and also provided a detailed comparison and analysis of the algorithms performance in path planning optimization. Finally, it discussed further research direction about bioinspired intelligent algorithms. [ABSTRACT FROM AUTHOR]

In order to study seismic behaviors of corroded squat reinforced concrete (RC) shear wall, such as bearing capability, deformation capacity and energy-dissipating capacity under different spacing of horizontal reinforcement and diameter of longitudinal reinforcement, five RC shear walls were accelerated corrosion under the artificial climate to simulated coastal atmospheric environment, and pseudo-static tests of these corroded specimens with the same corrosion degree and axial compression ratio were carried out. The results show that the corrosion cracks along the longitudinal reinforcement are wider than those along the horizontal reinforcement and stirrup of concealed column, while the corrosion rate gives an opposite results. Reducing the spacing of the transversely distributed reinforcements can decrease the degree of shear failure of corroded specimens and improve the bearing capacity, ductility and energy dissipation capacity of corroded specimens in different degrees. The ductility gets the highest increase, which leads to the reduction of the shear deformation. The improvement of the seismic behavior of corroded squat RC shear walls by increasing the horizontal reinforcement ratio can be achieved by increasing the diameter of the longitudinal reinforcement, which makes the bearing capacity get the highest increase. The shear deformation of corroded specimens also gets larger because the bending capacity of the corroded specimens is greatly improved and the shear failure is delayed. [ABSTRACT FROM AUTHOR]

In order to expedite the transition of the Yellow River Simulator into the operational phase and quickly make use of its positive role in the difficulties of water resources shortage, economic imbalance and ecological fragility in the Yellow River Basin, an intelligent calculation method system for the Yellow River Simulator had been thoroughly sorted out and implemented. Drawing upon the concept of intelligent computing, the vital importance of the Yellow River Simulator’s intelligent computing was articulated from the perspectives of data storage and preprocessing, simulation computing power, and swift responsiveness, as well as its significance in ecological conservation and management, efficient water resources utilization and disaster evaluation and mitigation. Based on the architectural framework of the Yellow River Simulator, four branches of intelligent computing methods, namely biomimetic intelligent computing, machine learning, fuzzy computing and intelligent computation were summarized in detail. Envisioning the transformative potential of intelligent computation methodologies for the Yellow River Simulator, this paper explored its huge application prospects in development planning, disaster management and resources allocation. [ABSTRACT FROM AUTHOR]

Flexible Job-Shop scheduling problem with uncertain processing time has gradually become a new research hotspot in production scheduling. This paper used time Petri net to model interval flexible Job-Shop scheduling problem,then it carried out the reachability analysis based on the state class graph generated by the net model,and calculated all feasible fired sequences. After the timing analysis of these fired sequences,this paper proposed a reverse step method to obtain optimal scheduling strategy for lower(upper) bound of minimum makespan by solving the linear programming problem. Finally,it gave an example to demonstrate the correctness and feasibility of the proposed method. The proposed method can provide an effective solution for the actual interval flexible Job-Shop scheduling problem. [ABSTRACT FROM AUTHOR]

BACKGROUND: Bone morphogenetic protein 2 (BMP-2) and vascular endothelial growth factor 165 (VEGF-165) are essential cytokines for bone repair. Lentiviral transfection of stem cells is important for studying the biological changes of doubly transfected cells. OBJECTIVE: To study the feasibility of human BMP-2 and human VEGF-165 dual gene transfection of bone marrow mesenchymal stem cells (BMSCs) and to explore the osteogenic capacity of doubly transfected cells. METHODS: Rabbit BMSCs were divided into four groups: untransfected group, blank vector group transfected with control lentivirus, BMP-2 group transfected with Lv-BMP-2/GFP, and BMP-2/VEGF-165 group transfected with Lv-BMP-2/GFP and Lv-VEGH-165/RFP. Expression of targeted proteins was detected using western blot at different time after transfection. MTT assay was used to detect cell proliferation in each group. Alkaline phosphatase activity was measured at 14 days after transfection. RESULTS AND CONCLUSION: (1) The corresponding green and red fluorescent protein expressions were observed under fluorescence microscope in the blank vector, BMP-2, and BMP-2/VEGF-165 groups. (2) The corresponding target proteins were highly expressed in the BMP-2 and BMP-2/VEGF-165 groups at 3 days after transfection, but no significant changes were detected at 7, 14, and 21 days after transfection (P > 0.05). (3) Compared with the BMP-2 group, the proliferation of cells was slightly faster in the BMP-2/VEGF-165 group (P < 0.05), but significantly lower in the untransfected group and blank vector group (P < 0.05). (4) The activity of alkaline phosphatase in the BMP-2, and BMP-2/VEGF-165 groups was significantly higher than that in the untransfected and blank vector groups (P < 0.05). These findings reveal that BMSCs were successfully transfected by hBMP-2 and hVEGF-165, and the dual gene transfection could promote the production of alkaline phosphatase, thereby accelerating the osteogenic differentiation of BMSCs. Subject headings: Bone Marrow; Mesenchymal Stem Cells; Bone Morphogenetic Proteins; Vascular Endothelial Growth Factors; Lentivirus Infections; Cell Proliferation; Tissue Engineering Funding: the National Natural Science Foundation of China, No. 31160199; the Natural Science Foundation of Guangxi Zhuang Autonomous Region, No. 2014GXNSFAA118263; the Scientific Research Project of Guilin Medical University, No. LX2014254 [ABSTRACT FROM AUTHOR]

Soushenji records many short stories, among which there is no lack of information related to textile and clothing. Soushenji includes both myths and objects of textile and clothing, and textile and clothing items that existed in the historical life at that time. However, the historians on textile and clothing have not paid enough attention to the information on textile and clothing in Soushenji because the storyline of the novels is strange. The description of textile and clothing in Soushenji is still quite valuable. Textile myths and metaphysical textile objects are the exaggerated performance of textile production, life and psychology at that time, and the emergence of which has a profound root cause and psychology of textile and clothing economy and culture. At the same time, the detailed description of the ancient real textile clothing items is also worth examining and researching. It is precisely because these descriptions in Soushenji must have a sense of immersion that readers at that time had a sense of identity with the plot of the novel. Therefore, the research in this aspect can provide a glimpse of people’s textile and clothing production and life in the Eastern Jin Dynasty from another dimension, and even some of the descriptions can be complementary to the history. Through the two-dimensional analysis of literature and archaeological objects, the article provides a cultural interpretation of the textile and clothing information in Soushenji on the one hand based on the socio-psychological point of view; and on the other hand, the textile and clothing items in Soushenji are examined and re-studied from the techno-historical point of view, with the aim of analyzing the history of textile and clothing of the Eastern Jin Dynasty in the context of two-dimensional analysis of myths and historical materials. Two major conclusions are drawn. First, the textile myths in Soushenji have a profound social psychology, and that the real social psychology of the groups engaged in clothing production can be found in the exaggerated and unconventional descriptions of the period. The myth of the giant cocoon expresses the low productivity of silk weaving and the legacy of the silk cult; the myth of Dong Yong and the weaving maiden is only a story of filial piety in Soushenji, irrelated with love, but a manifestation of the producers’ desire for superior skills; the myth of the silkworm maiden with horse skin is a simple misinterpretation of the similarity between the images of horse, silkworm and woman constructed by the producers in the production process, as well as an artificial link between the forbidden original silkworm, the heavenly horse and the earthly silkworm. The construction reflects the attempt to glimpse the mechanics of how things happened at the time from the connection. The depiction of Fuyao in Soushenji is nothing more than a mystical approach to the failure of people to find costume visions for political figures, and its emergence is rooted in the physical reflection of the idea of the Mandate of Heaven. Second, the weaving in Soushenji is a fabric woven on the basis of the design requirements of the costume, thicker and denser than silk, unlike the traditional understanding. The names of costume items in Soushenji follow the representational structures of “material + costume” and “shape + costume”, which became important representations of ancient Chinese costume items. [ABSTRACT FROM AUTHOR]

Precision agriculture can play an important role in the development of intelligent agricultural machinery, due to fertilizer saving, low labor intensity, and high work efficiency. Among them, the amount of fertilizer discharge can directly dominate the crop yield. Nevertheless, the fertilizer discharge device was in a closed state during the live broadcast operation. Therefore, the detection of particle fertilizer discharge has been one of the development trends of intelligent and precise operation. Various approaches have been developed to replace granular fertilizers in recent years, such as the rotational speed, doppler effect, dynamic weighing, photoelectric, visual, and electrostatic ones. However, the low accuracy of detection has limited in the rapeseed mechanical direct seeding, due mainly to the large and disordered flow of fertilizer particles. There is a high demand for the real-time detection of high-throughput granular fertilizers during high-speed operations. In this study, the high-throughput particle flow dispersion and diversion serialization of "collision dispersion +sieve diversion +spiral tube constraint" were proposed to fully meet the agronomic requirements of fertilization and high-speed operation in rapeseed direct seeding operation. The high detection accuracy was also obtained under the large and disordered flow of fertilizer particles. A parallel detection device was designed for the diversion order of granular fertilizer using the discrete diversion order mechanism. The key parameters were then determined for the sensing detection structure, uniform fertilizer tube, sieve diversion structure, and spiral tube. A multi-channel signal synchronous acquisition system was also designed for the detection device of rapeseed live broadcast granular fertilizer, according to the multi-channel parallel detection and sensing. A test bench was constructed using a spiral disturbance cone centrifugal fertilizer feeder. The device performance tests were conducted to verify the effectiveness of discrete diversion serialization. The results showed that there was a gradual decrease in the coefficient of variation for each channel diversion of the detection device in an inclined state, as the speed increased when the speed of the fertilizer discharger was 100-130 r/min (fertilizer discharge frequency 361.80-631.60 Hz). The coefficient of variation exceeded 6.08% for each channel diversion under normal field operation with an inclination of 0°-5°. Once the discharge frequency of single-channel fertilizer was 30-80 Hz, the accuracy of the detection device with the spiral tube increased by 7.3 percentage points, compared with the straight tube. The detection accuracy was not less than 90.11% within the speed range of 100~130 r/min after displacement compensation, which was 9.3 percentage points higher than before. The experiment of vibration fertilizer discharge showed that the low-frequency vibration (0-30 Hz) significantly improved the discretization of granular fertilizer and detection accuracy. There was a stable detection accuracy of intermediate frequency vibration (30-110 Hz). High-frequency vibration (110-150 Hz) broke the serialization constraint of granular fertilizer for low detection accuracy. There was no significant impact of different vibration frequencies on the uniformity of the flow distribution in the detection device. The coefficient of variation exceeded 4.98% for each channel diversion. Field experiments showed that there was no significant impact of the light, vibration, and dust on the detection device under normal field operating speeds of 4.3-7.0 km/h. The detection accuracy of the device was not less than 90.05% when the speed of the fertilizer discharger was 100-130 r/min. The detection device can be expected to detect the fertilization operation of the equipment, in order to improve the quality of fertilization operation [ABSTRACT FROM AUTHOR]

In order to study the mechanical properties of RC shear wall in severe cold area, the results of the quasistatic tests of eight RC shear walls under freezing-thawing cycles were analyzed. Considering the impacts of the number of the freezing-thawing cycles, the concrete compressive strength and axial load ratio on the strength and the ductility of squat RC shear walls, the correction coefficient calculation model of characteristic point load (displacement) of the skeleton curve from the freezing-thawing damage members were established with freezing-thawing damage variable D to characterize the damage degree of freezing-thawing damage of concrete. By taking into account the strength and stiffness degradation caused by the cumulative damage effect, a cyclic degradation index β was introduced, and then the hysteretic rules and restoring force model applied to squat RC shear wall specimens after freezing-thawing cycles were proposed. For verifying the accuracy of the model, four low RC shear walls subjected different freezing-thawing cycles were selected to calculate their hysteretic curves and cumulative hysteretic energy dissipation, which were compared with the experimental data. The results are in good agreement, which means the restoring force model shows a good precision and can provide a theoretical basis for elasto-plastic analysis of shear wall structures in cold regions. [ABSTRACT FROM AUTHOR]

The design problem of l1 filters was studied for a class of discrete-time switched singular systems with positive constraints and time-varying delays. Through construction of an appropriate co-positive Lyapunov function and with the average dwell time technique, sufficient conditions in the form of linear programming were provided to ensure the corresponding filtering error system to be positive, regular, causal and exponentially stable. In addition, the effect of the exogenous disturbance input on the system performance was also analyzed and discussed. The sufficient conditions and design mechanisms for the corresponding filter to ensure that the filtering error system has the prescribed l1 disturbance attenuation performance were also given. Finally, a simulation example was provided to verify the effectiveness and feasibility of the proposed method. [ABSTRACT FROM AUTHOR]

Based on the experiment about static simulation of drainage ditches, the article used typical non-point source soluble nitrate andammonia nitrogen as an example to analyze the changing process and study the effects of nitrate nitrogen and ammonia nitrogenconcentrations in the simulated drainage water of different operation periods. The results showed that ammonia nitrogen and nitrate nitrogen inthe drainage ditches of different operating periods could be purified effectively. The purification process had the characteristics of‘fastpurification, wave balance’，in which ammonia nitrogen concentration decreased faster than nitrate nitrogen and the range of ammonianitrogen concentration in the 'wave balance' stage（⩽2 mg·L-1）was lower than nitrate nitrogen（⩾3 mg·L-1）. The different operationperiods had great influence on the purification rate of ammonia nitrogen and nitrate nitrogen in the ditches at the initial stage of theexperiment , in which the purification rate：The multi-years ditch>the 7-month-old ditch跃the 1-month-old ditch. In addition to the nitratepurification rate of nitrate nitrogen in non-ecological ditches of different operation had significant difference, no significant difference in theremaining stages; There was no significant difference in the change of ammonia nitrogen concentration in the ditch at different operatingperiods, except for the 'fluctuating balance' stage of the 7-month-old ditch（P=0.03<0.05）. There was significant difference in the early stage and the 'wave balance' stage of the purification process about nitrate nitrogen in the 7-month-old ditch and the 1-month-old ditch,the trend of purification for the multi-years ditch was similar, and no significant difference. In summary, the experiment proved that thegrowth of ditch operation periods could enhance the ability of purifying nitrogen，which had certain significance for further exploring thedevelopment process of the drainage ditch, rational design and management of the ecological ditches. [ABSTRACT FROM AUTHOR]

Objective To investigate the independent predictive factors for significant liver histological changes (SLHCs) in patients with HBeAg - positive high - viral - load chronic hepatitis B virus (HBV) infection and a normal alanine aminotransferase (ALT) level. Methods A retrospective analysis was performed on the clinical data of 116 previously untreated patients with HBeAg - positive high - viral -load (HBV DNA≥105 copies/ml) chronic HBV infection and a normal ALT level ( <50 U/L) who were hospitalized in Shanghai Public Health Clinical Center Affiliated to Fudan University from June 2013 to August 2015. The definition of SLHCs was inflammation ≥G2 and// or fibrosis ≥S2. The t - test or Mann - Whitney U rank sum test was used for comparison of continuous data between groups, and the chi -square test was used for comparison of categorical data between groups. Univariate and multivariate regression analyses were used to determine independent predictive factors for SLHCs. Results Of all the 116 patients, 47 (40. 5% ) had SLHCs. The multivariate analysis showed that age ( OR =2. 828 , P < 0. 05 ) , ALT ( OR = 1.011, P <0.05) , and gamma - glutamyl transpeptidase ( GGT) ( OR = 1. 089, P <0. 05) were independent predictors for SLHCs in patients with HBeAg - positive high - viral - load chronic HBV infection and a normal ALT level. The patients aged ≤30 years had a significantly lower incidence rate of SLHCs than those aged > 30 years (21.6% vs 49.4% , X2 = 6. 42, P =0. 015 ) , the patients with ALT ≤30 U/L had a significantly lower incidence rate of SLHCs than those with 30 U/L < ALT≤ 50 U/L (17.6% vs 50.0% ,;X2 = 19. 86, P <0.001), and the patients with GGT ≤40 U/L had a significantly lower incidence rate of SLHCs than those with GGT >40 U/L (28. 8% vs 66. 7% , x2 = 28. 63 , P < 0. 001 ) . Conclusion In patients with HBeAg - positive high -viral - load chronic HBV infection and a normal ALT level, those with an age of > 30 years, ALT > 30 U/L, and GGT > 40 U/L tend to develop SLHCs and need liver biopsy. [ABSTRACT FROM AUTHOR]

Ｏｂjｅｃｔｉｖｅ　Ｔｏ ｉｎｖｅｓｔｉｇａｔｅ ｔｈｅ ｓｉｍｐｌｅ ｓｅｒｕｍ ｍａｒｋｅｒｓ ｆｏｒ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ ｉｎ ｃｈｒｏｎｉｃ ｈｅｐａｔｉｔｉｓ Ｂ （ＣＨＢ）ｐａｔｉｅｎｔｓ ｗｉｔｈ ａｎ ａｌａｎｉｎｅ ａｍｉｎｏｔｒａｎｓｆｅｒａｓｅ （ＡＬＴ）ｌｅｖｅｌ ｏｆ ＜2 ｔｉｍｅｓ ｕｐｐｅｒ ｌｉｍｉｔ ｏｆ ｎｏｒｍａｌ （ＵＬＮ）. Ｍｅｔｈｏｄｓ　Ｔｈｅ ｃｌｉｎｉｃａｌ ｄａｔａ ｏｆ 2７8 ＣＨＢ ｐａｔｉｅｎｔｓ ｗｉｔｈ ＡＬＴ ＜2 × ＵＬＮ （ＵＬＮ ＝40 Ｕ/ Ｌ）ｗｅｒｅ ａｎａｌｙｚｅｄ ｒｅｔｒｏｓｐｅｃｔｉｖｅｌｙ. Ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ ｗａｓ ｄｅｆｉｎｅｄ ａｓ ａ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｏｒｙ ａｃｔｉｖｉｔｙ ｇｒａｄｅ （Ｇ）≥2. Ｔｈｅ ｔ - ｔｅｓｔ ｗａｓ ｕｓｅｄ ｆｏｒ ｃｏｍｐａｒｉｓｏｎ ｏｆ ｎｏｒｍａｌｌｙ ｄｉｓｔｒｉｂｕｔｅｄ ｃｏｎｔｉｎｕｏｕｓ ｄａｔａ ｂｅｔｗｅｅｎ ｇｒｏｕｐｓ，ａｎｄ ｔｈｅ Ｋｒｕｓｋａｌ - Ｗａｌｌｉｓ ｒａｎｋ ｓｕｍ ｔｅｓｔ ｗａｓ ｕｓｅｄ ｆｏｒ ｎｏｎ - ｎｏｒｍａｌｌｙ ｄｉｓｔｒｉｂｕｔｅｄ ｃｏｎｔｉｎｕｏｕｓ ｄａｔａ；ｔｈｅ ｃｈｉ - ｓｑｕａｒｅ ｔｅｓｔ ｗａｓ ｕｓｅｄ ｆｏｒ ｃｏｍｐａｒｉｓｏｎ ｏｆ ｃａｔｅｇｏｒｉｃａｌ ｄａｔａ ｂｅｔｗｅｅｎ ｇｒｏｕｐｓ. Ｍｕｌｔｉｖａｒｉａｔｅ ｌｏｇｉｓｔｉｃ ｒｅｇｒｅｓｓｉｏｎ ａｎａｌｙｓｉｓ ｗａｓ ｕｓｅｄ ｔｏ ｉｄｅｎｔｉｆｙ ｉｎｄｅｐｅｎｄｅｎｔ ｐｒｅｄｉｃｔｏｒｓ ｆｏｒ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ ｉｎ ＣＨＢ ｐａｔｉｅｎｔｓ ｗｉｔｈ ＡＬＴ ＜2 × ＵＬＮ. Ｔｈｅ ｒｅｃｅｉｖｅｒ ｏｐｅｒａｔｉｎｇ ｃｈａｒａｃｔｅｒｉｓｔｉｃ （ＲＯＣ）ｃｕｒｖｅ ｗａｓ ｕｓｅｄ ｔｏ ｅｖａｌｕａｔｅ ｔｈｅ ｄｉａｇｎｏｓｔｉｃ ｖａｌｕｅ ｏｆ ｓｅｒｕｍ ｍａｒｋｅｒｓ ｉｎ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ. Ｒｅｓｕｌｔｓ　Ｏｆ ｔｈｅ 2７8 ＣＨＢ ｐａｔｉｅｎｔｓ ｅｎｒｏｌｌｅｄ，1７５ （62. ９％ ）ｈａｄ ｎｏ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ （Ｇ0 - 1 ｇｒｏｕｐ）ａｎｄ 103 （3７. 1％ ）ｈａｄ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ （Ｇ2 - 4 ｇｒｏｕｐ）. Ｔｈｅｒｅ ｗｅｒｅ ｓｉｇｎｉｆｉｃａｎｔ ｄｉｆｆｅｒｅｎｃｅｓ ｉｎ ＡＬＴ，ａｓｐａｒｔａｔｅ ａｍｉｎｏｔｒａｎｓｆｅｒａｓｅ，ａｌｋａｌｉｎｅ ｐｈｏｓｐｈａｔａｓｅ，ｇａｍｍａ - ｇｌｕｔａｍｙｌ ｔｒａｎｓｐｅｐｔｉｄａｓｅ （ＧＧＴ），ａｌｂｕｍｉｎ，ｇｌｏｂｕｌｉｎ，ｐｒｏｔｈｒｏｍｂｉｎ ｔｉｍｅ （ＰＴ），ｐｌａｔｅｌｅｔ，ａｂｓｏｌｕｔｅ ｎｅｕｔｒｏｐｈｉｌ ｃｏｕｎｔ，ｈｙａｌｕｒｏｎｉｃ ａｃｉｄ （ＨＡ），ｇｌｙｃｏｃｈｏｌｉｃ ａｃｉｄ，ｐｒｅｃｏｌｌａｇｅｎ Ⅲ，ａｎｄ ｃｏｌｌａｇｅｎ ｔｙｐｅ Ⅳ（ⅣＣ）ｂｅｔｗｅｅｎ ｔｈｅ ｔｗｏ ｇｒｏｕｐｓ （ａｌｌ Ｐ ＜0. 0５）. Ｔｈｅ ｍｕｌｔｉｖａｒｉａｔｅ ｒｅｇｒｅｓｓｉｏｎ ａｎａｌｙｓｉｓ ｓｈｏｗｅｄ ｔｈａｔ ＧＧＴ，ＰＴ，ⅣＣ，ａｎｄ ＨＡ ｗｅｒｅ ｉｎｄｅｐｅｎｄｅｎｔ ｐｒｅｄｉｃｔｏｒｓ ｆｏｒ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ ｉｎ ＣＨＢ ｐａｔｉｅｎｔｓ ｗｉｔｈ ＡＬＴ ＜2 × ＵＬＮ （ＯＲ ＝1. 01５，1. 600，1. 1５1，ａｎｄ 1. 014，Ｐ ＝0. 008，0. 021，0. 003，ａｎｄ 0. 018）. Ｔｈｅ ａｒｅａｓ ｕｎｄｅｒ ｔｈｅ ＲＯＣ ｃｕｒｖｅ ｆｏｒ ＧＧＴ，ＰＴ，ＩＶＣ，ａｎｄ ＨＡ ｔｏ ｄｉａｇｎｏｓｅ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ ｗｅｒｅ 0. 804，0. ７22，0. ７0７，ａｎｄ 0. 632，ｒｅｓｐｅｃｔｉｖｅｌｙ. Ｔｈｅ ｃｕｔ - ｏｆｆ ｖａｌｕｅ ｏｆ 48. ５ Ｕ/ Ｌ ｆｏｒ ＧＧＴ ｔｏ ｐｒｅｄｉｃｔ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ ｈａｄ ａ ｓｐｅｃｉｆｉｃｉｔｙ ｏｆ ９0. 3％ ａｎｄ ａ ｎｅｇａｔｉｖｅ ｐｒｅｄｉｃｔｉｖｅ ｖａｌｕｅ ｏｆ ７4. 6％ . Ｃｏｎｃｌｕｓｉｏｎ　ＧＧＴ，ＰＴ，ＩＶＣ，ａｎｄ ＨＡ ａｒｅ ｉｎｄｅｐｅｎｄｅｎｔ ｐｒｅｄｉｃｔｏｒｓ ｆｏｒ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ ｉｎ ＣＨＢ ｐａｔｉｅｎｔｓ ｗｉｔｈ ＡＬＴ ＜2 × ＵＬＮ，ａｍｏｎｇ ｗｈｉｃｈ ＧＧＴ ｈａｓ ｔｈｅ ｈｉｇｈｅｓｔ ｐｒｅｄｉｃｔｉｖｅ ｖａｌｕｅ. [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical features of acute hepatitis B (AHB) and acute exacerbation of chronic hepatitis B (CHB) for differential diagnosis. Methods A retrospective analysis was performed on the clinical data of 96 AHB patients and 124 patients with acute exacerbation of CHB, who were admitted to the Public Health Clinical Center Affiliated to Fudan University from June to December, 2014. Comparison of continuous data between the two groups was made by Mann Whitney U test, while comparison of categorical data was made by chi-square test. Results There were no significant differences in the age of onset and sex between the AHB group and the acute exacerbation of CHB group; the incidence was higher in males than in females. Sexual transmission and iatrogenic transmission were the main routes of transmission for AHB, while mother-to-child transmission was the main route of transmission for acute exacerbation of CHB. The sensitivity and specificity of alanine aminotransferase (ALT) level ≥1072 U/L for diagnosing AHB were 78.6% and 79.2%, respectively. The sensitivity and specificity of S/CO ≥13.6 in the anti-HBc-IgM test for diagnosing AHB were 94.5% and 89.3%, respectively. At week 2 after admission, the AHB group showed significantly greater decreases in levels of HBsAg, HBeAg, and hepatitis B virus (HBV) DNA than the acute exacerbation of CHB group (P＜0.05). At week 8 after admission, the AHB group had significantly higher HBsAg clearance rate, anti-HBs seroconversion rate, HBeAg clearance rate, anti-HBe seroconversion rate, and HBV DNA clearance rate than the acute exacerbation of CHB group (P＜0.05). ConclusionIt is helpful for making the differential diagnosis between AHB and acute exacerbation of CHB to know the route of transmission, ALT level, anti-HBc-IgM test result (S/CO value), HBV DNA clearance rate, and the seroconversion rates of HBV markers. [ABSTRACT FROM AUTHOR]

Chronic hepatitis B (CHB) is one of the major causes of liver cirrhosis and hepatocellular carcinoma. Interferon and nucleos(t)ide analogues can control disease progression. However, they cause very low HBsAg clearance or seroconversion rates and relapse in most patients after treatment withdrawal. In recent years, the further understanding of the interaction between hepatitis B virus (HBV) and host gives birth to a large number of novel drugs that hold promise for successful cure of CHB. This paper reviews several novel drugs against HBV in phase I, II, or III clinical trials, and points out that these novel drugs against HBV have preliminarily indicated a bright future. [ABSTRACT FROM AUTHOR]

There are about 150 million people around the world with chronic hepatitis C virus (HCV) infection currently, of whom 20% will ultimately progress to cirrhosis and eventually die of end - stage liver disease and hepatocellular carcinoma. Interferon (IFN) has long been recognized as the cornerstone of the treatment of chronic hepatitis C because of its role in sustained virologic response and prevention of disease progression. However, it has limited efficacy and multiple adverse effects. In recent years, direct - acting antiviral agents (DAAs) have shown good efficacy. This review summarizes the recent advances in IFN - free anti - HCV therapeutic regimens based on DAAs. We believe that, with the emergence of DAAs , IFN - free therapies will develop rapidly and display better prospects. [ABSTRACT FROM AUTHOR]

Non-alcoholic fatty liver disease (NAFLD) affects up to a third of the population in developed countries. Between 10% and 30% of patients with NAFLD have non-alcoholic steatohepatitis (NASH). There are metabolic risk factors common to both NAFLD and cardiovascular disease, so patients with NASH have an increased risk of liver-related and cardiovascular death. This articles reviews the most recent advances in the management of NAFLD in five main areas: lifestyle modification, weight loss treatment, therapy for metabolic syndrome, insulin sensitizer and antioxidant pharmacotherapy, and management of end-stage liver disease. It is pointed out that clinicians need to pay more attention to metabolic syndrome in the diagnosis and treatment of NAFLD. [ABSTRACT FROM AUTHOR]

Most of Chu textile cultural relics in China are unearthed from tombs. Due to the long age and poor storage environment textiles are often incomplete and damaged with rust spots blood stains and other blots on the surface. At present the restoration of textile cultural relics is still mainly physical restoration. The process of physical restoration depending on the subjective aesthetics and experience of the restoration personnel is easy to cause problems such as unsatisfactory restoration effect or secondary damage. In order to reduce the contact with textile cultural relics a digital method was used in this study to restore the textiles of Chu tombs at the image level. The textile image database was established by collecting the image data of textile cultural relics in Chu tombs. The generative adversarial network GAN model in the deep learning method was used to repair the incomplete textile cultural relics at the image level avoiding touching textile cultural relics and reducing the secondary damage in the repair process. At the same time the generator with the U-Net structure was used in the study to reduce the number of down-sampling and up-sampling cancel the pooling layer and jump connection introduce dilated convolution expand the receptive field and reduce the loss of textile image data information. According to the characteristics of repeatability and regularity of textile images of Chu tombs we adopted adaptive step size for the generator. The larger the repair area the more the details and the more complex the pattern are and the smaller the step size should be. The smaller the repair area the less the details and the simpler the pattern are and the bigger the step size should be so that the computational efficiency can be improved. The discriminator is of seven-layer network structure including six convolutional layers and one fully connected layer. The ReLU function was selected as the activation function in the convolutional layers and the Sigmoid function was selected in the fully connected layer. By learning the data information input into the known area of the textile image database the generator generated data information close to the unknown area of the real textile image so as to restore the textile image. The discriminator was used to determine the authenticity of the generated image to adjust the parameters and the Chu textile image restoration was achieved through continuous optimization of the two. In order to further test the effectiveness of the repair model proposed in this study the typical image repair method DeepFill v2 algorithm was selected for comparative experiments. The image restored by DeepFill v2 is relatively blurred with artifacts noise and other phenomena. The image restored by the method proposed in this study is clear with the structure and pattern of the textile image being basically restored. In this study a digital method is proposed to repair some textile cultural relics unearthed from Chu tombs which are difficult to repair and fragile. The images of textile cultural relics are restored by the digital method to make the structure complete and pattern coherent which achieves a good restoration effect from subjective evaluation perspective. The restored textile relic images can be used to guide the restoration of physical objects exhibitions etc. which has certain significance for the study of Chu tomb textiles. [ABSTRACT FROM AUTHOR]

In this study, through field experiments, the effects of different proportions of earthworm fertilizer mixed with soil conditioner SA1(1.50 kg/m² of earthworm fertilizer, 3.00 kg/m² of soil conditioner), SA2(2.25 kg/m² of earthworm fertilizer, 2.25 kg/m² of soil conditioner), SA3(3.00 kg/m² of earthworm fertilizer, 1.50 kg/m² of soil conditioner), and the control on the physical and chemical properties of saline alkali soil and the growth of Leymus chinensis were studied, in order to provide some theoretical support for the improvement of saline alkali land with earthworm fertilizer mixed with soil conditioner. The results show that earthworm fertilizer mixed with soil conditioner could effectively improve the physical properties of saline alkali soil. Compared with the control, the soil moisture content of SA1, SA2, and SA3 significantly increased by 3.32%, 12.96% and 27.68%, respectively, and the bulk density decreased by 4.61%, 3.31%, and 6.62%. Earthworm fertilizer mixed with soil conditioner could effectively improve the chemical properties of saline alkali soil. Compared with the control, the pH of SA1, SA2, and SA3 decreased by 5.18%, 8.15%, and 5.73%. Compared with the control, organic matter and available nutrients were significantly improved. The increase of available phosphorus was the most significant, the value of SA1, SA2, and SA3 increased by 54.67%, 105.95%, and 129.76%. Compared with the control, the plant height, biomass, and leaf area of SA1, SA2, and SA3 significantly increased. The increase of the plant height, biomass, and leaf area of SA3was the most obvious and reached the level of significance, the values increased by 12.36%, 136.34%, and 96.53%, respectively. According to principal component analysis, the comprehensive improvement effect of SA3 was the best, with a score of 2.70. In conclusion, applying earthworm fertilizer mixed with soil conditioner could be an effective measure to improve the physical and chemical properties of saline alkali land and promote the growth of Leymus chinensis. [ABSTRACT FROM AUTHOR]

Subarachnoid hemorrhage (SAH) leads to ferroptosis with clinical evidence like iron metabolism deregulation, increased lipid peroxitation (LPO) and the inhibition of glutathione/glutathione peroxides 4 (GSH/GPX4). Ferroptosis mediated early brain injury (EBI) may occur in the 72-hour period following SAH (EBI-SAH) leads to the poor prognosis of SAH. Pharmacological targeting at ferroptosis mitigate EBI-SAH, provides a new target for future treatment and prevention of EBI-SAH through targeting at ferroptosis. [ABSTRACT FROM AUTHOR]

Two sets of multi-source precipitation fusion analysis products FAST and FRT products from 2020 to 2021, and the hourly precipitation data of 35 national meteorological stations in Chongqing after quality control were used to test the correlation and error of the two sets of products in combination with the topographic factors of each station, so as to provide data support for hydrometeorological research under complex terrain. Some results in this study showed that: (1) FAST and FRT products had good correlation with the observed value, positive correlation and small error. The overall product was lower than the observed value, and there was a slight difference between them. (2) On monthly and seasonal time scales, the accuracy of spring was the best, and the error and dispersion degree of flood season from May to September were the largest. (3) With the increase of precipitation grade, the distribution of product error, correlation and TS grade score became more discrete, the absolute value of error gradually increased, the TS grade score gradually decreased, and the correlation first decreased and then increased, among which the correlation of precipitation grade 0.1-1.9mm and ≥ 20mm was better. (4) In terms of terrain factors, the accuracy of products was slightly different, among which the accuracy of products on the slope was the best, followed by the flat slope, above the steep slope and gentle slope. The accuracy of products with undulation greater than 70m was the best; With the increase of altitude, the product accuracy decreased first. When the altitude was greater than 700m, the product accuracy increased. The accuracy of products with the Southwest and East slope directions was better, and the Southwest slope direction was the best. FAST and FRT precipitation products had high accuracy in Chongqing, which could effectively supplement the precipitation data in areas with few automatic stations. [ABSTRACT FROM AUTHOR]

Objective To establish a method for the determination of estradiol and progesterone contents illegally added in some brand ginseng tea reducing weight(sample 1) and some brand Paidu Yangyan oral liquid(sample 2). Methods The chromatographic Agilent C18column(4.6 mm×250.0 mm, 5 μm)was adopted with acetonitrile-water(70∶30) as the mobile phase;the flow rate was 1.0 m L/min,the detection wavelength was 225 nm and the column temperature was 30 ℃. Results Estradiol in the range of 5.7~57.2 μg/m L had good linearity(r=0.999 5), progesterone in the range of 0.57~22.70 μg/m L had good linearity(r=0.999 6); the average recovery rates(n=6) of estradiol and progesterone were 98.51% and 99.37% respectively. The contents of estradiol and progesterone in the sample 1 were 47.32, 166.85 μg/g respectively and which in the sample 2 were 54.71, 392.56 μg/g respectively. Conclusion This HPLC method is simple and quick with good repeatability and accurate detection results, and can be used as the determination method of estradiol and progesterone contents in the health care products. [ABSTRACT FROM AUTHOR]

BACKGROUND: Skin damage caused by radiation therapy and nuclear accidents is still a serious medical problem. It is difficult to achieve effective treatment results with single prevention and treatment methods. It is an important research direction to find new comprehensive treatment methods. OBJECTIVE: To observe the protective effect and the underlying mechanism of 1,2-propanediol combined with hepatocyte growth factor-modified exosomes derived from dental pulp stem cells on human epidermal radiation damage cell models. METHODS: (1) After infection of human dental pulp stem cells using recombinant adenovirus of human hepatocyte growth factor gene, exosomes, i.e., Ad. HGF DPSC-Exo, were isolated with ultracentrifugation. (2) HaCat cells were irradiated with X-ray. The cells were treated with 1,2-propanediol before irradiation and Ad.HGF DPSC-Exo after irradiation. Cell proliferative activity was determined by CCK-8 assay. Cell apoptosis was detected by flow cytometry. Cell migration was detected by cell scratch assay. The expression levels of P21 and P53 were detected by PCR. RESULTS AND CONCLUSION: 1,2-Propanediol, Ad.HGF.DPSC-Exo, Ad.HGF.DPSC-Exo + 1,2-propanediol could significantly improve the growth inhibition of HaCaT cells, reduce cell apoptosis, elevate cell proliferation and migration, and exhibit a good radiation protection effect. Moreover, the combined effect of Ad.HGF.DPSC-Exo + 1,2-propanediol was better. Furthermore, Ad.HGF.DPSC-Exo + 1,2-propanediol alleviated the cellular G2/M phase block and decreased the expression of cell cycle genes P53 and P21. In conclusion, 1,2-propanediol pretreatment combined with Ad.HGF.DPSC-Exo had significant protective effects on radiation-induced HaCaT cell injury and it provided novel ideas and potential methods for the prevention and treatment of radiation-induced skin damage. [ABSTRACT FROM AUTHOR]

The solid waste-based autoclaved aerated concrete (AAC) was prepared by granite stone powder and yellow river superfine sand as siliceous materials, carbide slag as calcareous material, as well as poly carboxy late superplasticizer as modifier. The effects of polycarboxylate superplasticizer dosage on paste fluidity, gassing process, compressive strength, dry density, porosity and pore size distribution of AAC were investigated. The results showed that when the water reducing agent dosage increased from 0.15% to 0.30%, the initial fluidity of the paste, the rate of gassing, the amount of gassing and porosity all gradually increased, and the compressive strength and dry density of the products gradually decreased. When the water reducing agent dosage was 0.25, the paste initial fluidity was 270 mm, the air generation was 208 mL, the porosity was 82.54%, the compressive strength was 2.9 MPa, the dry density was 509 kg/m1³, and the overall performance of A AC was optimal. When the water reducing agent dosage was larger than 0.2%, the large pores above 2 mm almost disappeared, and the porosity and the content of harmless pores in the pore wall had a more obvious effect on the compressive strength of A AC. [ABSTRACT FROM AUTHOR]

In order to find out the content of soil nutrients and chemical quality indicators of tobacco in the tobacco growing area of Shizong, Yunnan, and to provide a basis for the rational layout and scientific and accurate fertilization of roasted tobacco production. Soil samples and tobacco leaf samples were collected from seven township areas in Shizong County and 110 samples were collected and analysed for soil nutrients and chemical quality of tobacco leaf. This study showed that soil pH and effective calcium decreased with increasing altitude in the area, while altitude had no significant effect on other soil nutrients and tobacco quality. The overall soil pH in the Shizong area is suitable for tobacco plant growth, with 60% in the optimum range;92. 7% of the soil organic matter is in the ‘high’ and ‘very high’ range. The total nitrogen content of the bulk elements was in the ‘high’ and ‘very high’ range for 85. 5% of the total, while most of the alkaline nitrogen content was medium (63. 9%), 23. 1% in the ‘very high’ range and 13% in the ‘low’ range. Total phosphorus and potassium were deficient in the ‘low’ and ‘very low’ ranges, accounting for 71. 8% and 90. 7% respectively;however, fast-acting phosphorus and fast-acting potassium occupied The proportion of ‘medium’ and above was 98. 2% and 78. 1% respectively. The overall content of trace elements is high, but 29. 6% of effective sulphur and 25. 9% of effective molybdenum are at the ‘low’ and ‘ very low’ levels respectively, 100% of effective calcium and effective magnesium are at the ‘high’ and above levels, and effective copper, effective iron, effective manganese and water-soluble chlorine are abundant. However, 29. 6% of effective sulphur and 25. 9% of effective molybdenum were at ‘low’ and ‘very low’ levels respectively, 100% of effective calcium and effective magnesium were at ‘high’ and above levels, while effective copper, effective iron, effective manganese and water-soluble chlorine were abundant. The region should pay attention to the application of potassium and sulphur fertilizers and reduce calcium and magnesium inputs. [ABSTRACT FROM AUTHOR]