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Objective To explore the impact of passive smoking during pregnancy on neurobehavioral developmental abnormalities in 1 - year - old children. Methods 1 363 pairs of mothers and children from the Shenzhen birth Cohort study platform were selected as the research objects. Questionnaire was used to investigate the general demography characteristics and passive smoking of pregnant women during pregnancy, and the age and development process questionnaire (ASQ - 3/ASQ: SE) was used to assess the neurobehavioral development of children at one year old. Analyze the impact of passive smoking during pregnancy on neurobehavioral developmental abnormalities in 1 - year - old children using a logistic regression model. Results Passive smoking during pregnancy had varying degrees of harmful effects on the development of 1 - year - old children, except for gross movements. Compared with those without passive smoking, pregnant women with severe passive smoking in early pregnancy had an increased risk of delayed development in communication (OR - 1. 932, 95% Cf: 1. 023 - 3. 648), fine motor skills (OR = 3. 388, 95% CI: 1. 232 - 9. 317), problem - solving (OR = 3. 270, 95% CI: 1. 317 - 7.795), and social emotional development (OR = 1.792, 95% CI: 1. 159 - 2.772) among their offspring. In mid - pregnancy, pregnant women who smoke passively had an increased risk of delayed development in communication (OR = 1, 802, 95%CI: 1.068 -3.039) and personal social (OR = 1.705, 95% CI: 1.080 -2.837) among their offsprings while pregnant women who smoke heavily had an increased risk of delayed development in communication (OR = 2. 864, 95% CI: 1.322-6.240) and social emotional (OR = 1.882, 95% CI: 1. 081 - 3.275) among their offspring. In late pregnancy, pregnant women with severe passive smoking had an increased risk of delayed communication (OR = 3. 415, 95 % CI: 1. 366 - 3. 158), fine motor skills (OR = 3. 976 times, 95% CI: 1. 838 - 13. 360), and social emotional development (OR = 2. 231, 95% C/: 1. 234 - 4. 032) in their offspring. Conclusion Passive smoking in the early, middle, and late stages of pregnancy can have varying degrees of harmful effects on the neurobehavioral development of offspring at one year old. Suggest relevant departments to increase publicity and education efforts, guide the public to reduce indoor smoking and pay attention to maternal health and early neurobehavioral development in children. [ABSTRACT FROM AUTHOR]

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Objective To verify the predictive value of FRAX by using rheumatoid arthritis (RA) in patients with T2DM. Methods 324 T2DM patients hospitalized in a Grade A hospital from January to May 2023 were selected and divided into OP and non-OP groups, their general clinical data and bone density were collected, and RA option in FRAX was replaced with T2DM for scoring. The differences in general clinical data and corrected FRAX scores were compared between the two groups. The predictive ability of FRAX after RA correction can be analyzed by logistic regression model and ROC curve, and its intervention threshold can be determined by sensitivity and specificity. Ninety-three T2DM patients who hospitalized during June to July 2023 were used to verify their clinical application value. Results The proportion of women, OP group, higher age, longer diabetes duration, previous fracture history, glucocorticoid use and adjusted MOFP and adjusted HFP were higher than the non-OP group; weight and BMI were lower than the non-OP group (P<0.05). In the validation group, the proportion of women, age, duration of diabetes, BMI, adjusted MOFP, and number of adjusted HFP were higher than those without fracture, with P<0.05. Conclusion The correction for FRAX-MOFP 6% or correction for FRAX-HFP 3% had good accuracy as the intervention threshold, and RA correction for FRAX could improve the probability of fracture risk assessment for T2DM patients in western Guangxi. [ABSTRACT FROM AUTHOR]

针对退化率较高的产品具有不稳定的退化路径以及产品个体差异对退化过程的影响，建立了一种新的随机效应退化模型，即漂移参数和扩散参数均为随机变量且两者之间呈线性关系的Wiener退化过程模型.基于该模型获得了产品剩余寿命分布与可靠度函数，同时设计了估计模型参数的EM (expectation maximization)算法.最后，通过分析钛合金疲劳裂纹数据以及与现有模型结果的比较，验证了所建模型的有效性和准确性.

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Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To probe into the correlation between ERCC1 expression and clinicopathological characters and efficacy of postoperative platinum-based adjuvant chemotherapy in esophageal cancer. METHODS: 115 patients with esophageal cancer accepting operation in Shanxi Tumor Hospital from Jan. 1st 2013 to Jun. 30th 2015 were selected to conduct die ERCC1 expression detection, correlation of ERCC1 expression and clinicopathological characters were analyzed. RESULTS: The positive expression of ERCC1 was 54.8% (63/115). The 1-year recurrence rale of positive expression of ERCC1 patients with postoperative platinum-based adjuvant chemotherapy was 17. 1% (6/35), 1-year survival rale was 82. 6% (29/35). And I -year recurrence rale of negative expression of ERCC1 patients with postoperative platinum-based adjuvant chemotherapy was 11. l%(3/27), 1-year survival rale was 88.9% (24/27). CONCLUSIONS: There are no correlation between ERCC1 expression and patients gender, age, location, length of tumor, degree of tumor differentiation, pathological type, lympho node metastasis and international TNM staging system. The 1-year recurrence rale of positive expression of ERGC1 patients with postoperative platinum-based adjuvant chemotherapy was higher than that of ERCC1-negative patients. Therefore, patients with ERCC1-negative esophageal cancers may benefit from platinum-based adjuvant chemotherapy. [ABSTRACT FROM AUTHOR]