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基于昼夜节律的相关认识阐述卒中发病的时间规律及影响因素，探讨卒中防控的新策略。 收集、整理现代医学关于昼夜节律与卒中发病时间的相关性文献，进行综合分析。卒中发病存在显 著的昼夜差异并具有周期性变化，血压、血糖、血脂、Hcy等相关因素出现昼夜节律紊乱可能是导致 卒中存在高发时段的部分原因。适时服用防治药物，调整生活方式，保持自身昼夜节律的稳定，是健 全卒中防控策略和降低卒中发病风险的重要措施。 Abstract: To explore the circadian variation in the timing of stroke and related influence factors based on the theory of circadian rhythm, to provide ideas for prevention strategy of stroke. Literature on correlation between circadian rhythm and the onset time of stroke were searched and analyzed, and the results showed that there were significant diurnal variations and cyclical changes in the timing of stroke. Circadian rhythm disorders caused by blood pressure, blood sugar, blood lipids, homocysteine may partly influence the occurrence of stroke. Healthy lifestyle and keeping blood pressure, blood sugar and blood lipids normal are all very important for keeping the circadian rhythm stable, which are also the important measures of stroke prevention.

Copyright of Journal of Test & Measurement Technology is the property of Publishing Center of North University of China and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: A large number of studies have confirmed that the therapeutic effectiveness of mesenchymal stem cell secretome is comparable to that of mesenchymal stem cells, but the mechanism of its action is still unclear. OBJECTIVE: To summarize the research progress of mesenchymal stem cell secretome in recent years, to investigate the molecular mechanism of its therapeutic effect, to analyze the current problems and to look forward to the future development. METHODS: The terms “exosomes, mesenchymal stem cells secrete, extracellular vesicles, mesenchymal stem cells, mechanism” were used as English search terms in the PubMed database. Articles that were not related to the research purpose of the article and duplicated articles were excluded. At the same time, we combined the method of literature tracking. Finally, 109 articles that met the criteria were incuded for the review. RESULTS AND CONCLUSION: (1) The mesenchymal stem cell secretome promotes tissue repair and regeneration through delivering genetic material, immunomodulatory factors, growth factors, etc. to target cells, by activating anti-apoptotic, regulating angiogenesis, modulating fibrosis and pro-survival pathways in target cells. (2) The potential of mesenchymal stem cell secretome in disease therapy has also been confirmed. Numerous research results have shown that mesenchymal stem cell secretome can be used as a new cell-free treatment for inflammatory and degenerative diseases. (3) Mesenchymal stem cell secretome has been engineered to have more efficient therapeutic effects in recent years. However, due to the heterogeneity of the mesenchymal stem cell secretome and the complexity of its components, the exact mechanism of its therapeutic effect is still unclear. (4) At present, further research is needed to identify the key targets of mesenchymal stem cell secretome, and innovative specific and enhanced mesenchymal stem cell secretome should be developed by combining with engineering and genetic engineering technologies in the future. [ABSTRACT FROM AUTHOR]

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Copyright of Guangdong Agricultural Sciences is the property of South China Agricultural University, Guangdong Academy of Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Smart Agriculture is the property of Smart Agriculture Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the clinical application value of modified 7Fr pancreatic duct plastic stent in biliary drainage. Methods Clinical data were collected from 121 patients with choledocholithiasis who underwent endoscopic retrograde cholangiopancreatography (ERCP) lithotomy and biliary drainage in Department of Hepatobiliary Surgery, The Affiliated Hospital of Guizhou Medical University, from April 2021 to June 2022, and according to the method for postoperative biliary drainage, they were divided into modified stent group with 59 patients and nasobiliary drainage group with 60 patients. The patients in the modified stent group received drainage with the modified 7Fr pancreatic duct plastic stent, and those in the nasobiliary drainage group received nasobiliary drainage. A retrospective analysis was performed for their clinical data, and stent dislodgement was observed for the modified stent group. The two groups were compared in terms of clinical outcome, postoperative comfort, and postoperative complications. The independent-samples t test was used for comparison of normally distributed continuous data between groups, and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between groups; the chi-square test was used for comparison of categorical data between groups. Results Both groups achieved a stone clearance rate of 100%. There were significant differences between the two groups in the length of postoperative hospital stay and the total length of hospital stay (t = -3.997 and 2.317, both P ＜0.05). After treatment, both groups had significant reductions in total bilirubin (TBil), direct bilirubin (DBil), indirect bilirubin (IBil), alkaline phosphatase (ALP), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (all P ＜0.05), and there were no significant differences between the two groups in the changes in TBil, DBil, IBil, ALP, alanine aminotransferase, and AST after treatment (all P ＞0.05). Also, no significant differences were observed between the two groups in the changes in biochemical parameters after treatment (all P ＞0.05). There were significant differences between the two groups in comfort score within 24 hours after surgery and the time to first eating and drinking after surgery (t = 2.001, 3.579, and 4.604, all P ＜0.05). There were no significant differences in complications between the two groups (all P ＞0.05). In the modified stent group, the rate of spontaneous stent dislodgement was 83.05%, and there were no complications such as stent occlusion, displacement, rupture, perforation, and infection. Conclusion After complete bile duct stone removal by ERCP, biliary drainage using the modified 7Fr pancreatic duct plastic stent has a similar effect to nasobiliary drainage and can shorten the length of postoperative hospital stay, improve postoperative comfort, and accelerate postoperative recovery, with a relatively high spontaneous dislodgement rate. Therefore, it is safe and effective in clinical practice. [ABSTRACT FROM AUTHOR]

Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Prataculturae Sinica is the property of Acta Prataculturae Sinica Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

As a substitute for inorganic glass, organic optical resin has the advantages of light mass, good impact resistance, easy processing, and strong adjustability. The refractive index is one of the main parameters of optical resins. The level of refractive index can directly affect the thickness, aesthetics and comfort of the finished lens. Improving the refractive index of optical resins without reducing the overall performance of optical resins has always been a hot and difficult point in this field. The introduction of sulfur with high molar refractive index into optical resins is considered to be one of the most effective and commonly used methods. In this paper, sulfur-containing optical resins are divided into olefins, epoxys, episulfides, sulfur heterocyclic rings, and polyurethanes. The research progress in recent years at home and abroad is briefly reviewed, involving monomer synthesis, monomer polymerization, and the influences of monomer structures on the comprehensive performances of optical resins. The properties and development of the above materials are also analyzed. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Chongqing University of Posts & Telecommunications (Natural Science Edition) is the property of Chongqing University of Posts & Telecommunications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)