间充质干细胞分泌组发挥作用的分子机制.

BACKGROUND: A large number of studies have confirmed that the therapeutic effectiveness of mesenchymal stem cell secretome is comparable to that of mesenchymal stem cells, but the mechanism of its action is still unclear. OBJECTIVE: To summarize the research progress of mesenchymal stem cell secretome in recent years, to investigate the molecular mechanism of its therapeutic effect, to analyze the current problems and to look forward to the future development. METHODS: The terms “exosomes, mesenchymal stem cells secrete, extracellular vesicles, mesenchymal stem cells, mechanism” were used as English search terms in the PubMed database. Articles that were not related to the research purpose of the article and duplicated articles were excluded. At the same time, we combined the method of literature tracking. Finally, 109 articles that met the criteria were incuded for the review. RESULTS AND CONCLUSION: (1) The mesenchymal stem cell secretome promotes tissue repair and regeneration through delivering genetic material, immunomodulatory factors, growth factors, etc. to target cells, by activating anti-apoptotic, regulating angiogenesis, modulating fibrosis and pro-survival pathways in target cells. (2) The potential of mesenchymal stem cell secretome in disease therapy has also been confirmed. Numerous research results have shown that mesenchymal stem cell secretome can be used as a new cell-free treatment for inflammatory and degenerative diseases. (3) Mesenchymal stem cell secretome has been engineered to have more efficient therapeutic effects in recent years. However, due to the heterogeneity of the mesenchymal stem cell secretome and the complexity of its components, the exact mechanism of its therapeutic effect is still unclear. (4) At present, further research is needed to identify the key targets of mesenchymal stem cell secretome, and innovative specific and enhanced mesenchymal stem cell secretome should be developed by combining with engineering and genetic engineering technologies in the future. [ABSTRACT FROM AUTHOR]