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Objectives: Using battlefield text data for spatiotemporal topic analysis, we can obtain the spatial distribution pattern of geographical environment elements and their impact characteristics on battlefield activities from micro to macro and from scattered to gathering places, and mine the spatial distribution and development law of battlefield events, which further enriches the perception mode of battlefield environment and provides a new means of battlefield environment efficiency analysis. It is of great significance and value for in-depth understanding of battlefield environmental knowledge. Methods: The key technology to improve the quality of spatiotemporal topic discovery in geographical environment is to effectively construct entity composite relationship network and integrate multi-dimensional heterogeneous relationships for topic clustering. First, a spatiotemporal topic tensor model integrating multi-dimensional relationships is constructed, and the complete expression of topic relationship is given by using the Tucker decomposition of topic tensor model. Then, the feature vector space of multi-dimensional relational clustering is constructed as the objective function of topic classification, and the block value matrix decomposition technology is used for joint clustering calculation, and the core tensor matrix is used to solve the problem of data sparsity. Finally, the block value matrix obtained by multi-dimensional relational clustering is used to obtain the association value between geographical environment elements and spatiotemporal topics. Results: The results show that: (1) The geographical environment entities and entity relationships are correctly clustered into spatiotemporal topic structure. The accuracy rates in the training set were 88.4% and 86.9% respectively, and in the test set were 87.3% and 85.8% respectively. (2) The number of entities and tags clustered under different subject structures decreases gently with the reduction of subject scale. The statistical results show that the most subject tags are maneuver, attack and interception, and the most location tags are highlands, roads and villages. (3) Compared with latent Dirichlet allocation (LDA) algorithm, the multi-dimensional relationship joint clustering method can be seen that the number of entities and labels mined by this algorithm is generally higher than LDA algorithm, so it can be seen that the accurate and clear space-time topic structure can be obtained after integrating multi-dimensional relationships. (4) The block value matrix obtained by multi-dimensional relationship clustering reflects the internal characteristic relationship of the spatiotemporal topic structure of the geographical environment, indicating that the spatial-temporal theme has strong cohesion. Conclusions: This method can effectively improve the quality and efficiency of spatiotemporal topic discovery, making the obtained topics better show the cohesive correlation between geographical environment elements, geographical location and event topics, providing a basis for clearly reflecting the evolution process of spatiotemporal topics, and supporting for mastering the development trend of events. Since this paper only takes the co-occurrence frequency of entity words as the weight value in the construction of relationship matrix, there is a certain deviation in data analysis. In the future, we will combine the attention mechanism to dig deep into multi-source text data, improve the efficiency and accuracy of data analysis, and establish the temporal and spatial correlation between different hot spots on the basis of effectively discovering cohesive hot spots, for inferring the event change process and providing an important reference value for the dynamic deduction of battlefield environment. [ABSTRACT FROM AUTHOR]

In order to deeply understand the freeze-heave and thawing characteristics of cement improved silty clay, taking the silty clay in the typical soil layer of Fuzhou Metro Line 4 as an example, the influences of four factors including cement slurry content, curing age, freezing temperature and water-cement ratio on cement improved silty clay were analyzed. The freeze-heave and thawing law of the improved soil under the action of single factor was obtained, and the optimal cement content of the improved soil was determined to be 20% . The optimum water-cement ratio is 0. 8, and the development law of temperature field in the process of frost heave and melt sedimentation test is obtained through temperature monitoring. Multiple linear regression equations were established by SPSS Statistics to predict the frost heave rate of cement improved silty clay under the comprehensive action of multiple factors. Through analysis, it was found that the degree of influence on the frost heave rate was as follows: cement infiltration amount > curing age > cold end temperature > water-cement ratio. [ABSTRACT FROM AUTHOR]

Osteoporosis (OP) is a common disease in the elderly, characterized by decreased bone strength, decreased bone density, and increased risk of fractures. Ferroptosis is a novel iron-dependent programmed cell death process that is critical in regulating the development of osteoporosis, but its underlying mechanism is complex. This article discusses the molecular mechanism of ferroptosis in osteoporosis and related research progress, in order to provide new references for future research on ferroptosis and osteoporosis. [ABSTRACT FROM AUTHOR]

Background Chronic superficial gastritis（CSG） is a common clinical disease in children. The emotional behavior of CSG children is susceptible due to them suffering from such disease at young age.Objective To explore the impact of coping strategies on emotional behavior and the effect of family function in children with CSG, and to provide references for clinical intervention in CSG children with emotional behavior problems.Methods A total of 177 children with CSG admitted to Anhui Children’s Hospital from June 2019 to January 2023 were selected as the research subjects. Investigation on family function, emotional and behavioral problems and coping strategies of children was conducted by employing the Family APGAR index（APGAR）, the Strengths and Difficulties Questionnaire（SDQ） and Coping Strategies Questionnaire（CSQ）. The structural equation model was used to test the mediating effect of family function between coping strategies and emotional behaviors.Results The APGAR score was negatively correlated with both SDQ score and negative coping strategies score（r=-0. 507,-0. 551, P＜0. 01）, but was positively correlated with positive coping strategy score（r=0. 579, P＜0. 01）. The positive coping strategy score was negatively correlated with SDQ score（r=-0. 539, P＜0. 01）, while the negative coping strategy score was positively correlated with SDQ score（r=0. 543, P＜0. 01）. The result showed that family function played a partial mediating role between positive coping strategies and emotional behavior [indirect effect was-0. 133（95% CI:-0. 256～-0. 079, P＜0. 01）, accounting for 29. 40% of the total effect]. The same mediating effect happened between negative coping strategies and emotional behavior [indirect effect was 0. 093（95% CI: 0. 198～0. 045, P＜0. 01）, accounting for 28. 50% of the total effect].Conclusion Coping strategies of CSG children can affect emotional behavior directly and indirectly with family function playing a partial intermediary effect. [ABSTRACT FROM AUTHOR]

Objective To investigate the role and mechanism of growth differentiation factor (GDF) 15 in ischemia-reperfusion injury (IRI) during kidney transplantation. Methods Nine wild type donor mice and 9 wild type recipient mice were selected. The renal graft of 3 recipient mice were harvested at 4, 24 and 72 h after transplantation. GDF family transcriptome analysis was carried out, and the expression of GDF15 in renal tissues of each group were detected. Five wild type donor mice, 5 GDF15 knockout donor mice and 10 wild type recipient mice were selected. According to the experimental scheme, the mice were divided into wild type sham operation group, wild type transplantation group, GDF15 knockout sham operation group and GDF15 knockout transplantation group. Serum and renal tissue samples were extracted 72 h after transplantation. The renal function, renal tubular injury, inflammatory cell infiltration, inflammatory factors, Toll-like receptor 4 (TLR4) and nuclear factor (NF)-κB expression level were compared in each group. Nine wild type donor mice, 9 GDF15 knockout donor mice and 18 wild type recipient mice were selected. According to the experimental scheme, the mice were divided into wild type transplantation group and GDF15 knockout transplantation group, and the survival rate of two group after kidney transplantation was observed. Results Transcriptome sequencing of renal graft tissues indicated that GDF15 was the most up-regulated GDF family gene, which was mainly expressed in renal tubules. Compared with the sham operation group, the renal function of mice was declined in the transplantation group. Compared with the wild type transplantation group, the serum creatinine and blood urea nitrogen levels of mice were significantly up-regulated in the GDF15-knockout transplantation group (both P<0.05). The 1-week survival rate of mice was 87.6% in the wild type transplantation group and 41.8% in the GDF15 knockout transplantation group. In the GDF15 knockout transplantation group, the expression level of kidney injury molecule (KIM)-1 was up-regulated, and the renal tubule injury score was increased. In the wild type transplantation group, the renal tubules were dissolved or necrotized, and tubular formation was seen in the extramedullary and cortex area, whereas tubular necrosis and tubular formation were more evident in the GDF15 knockout transplantation group. The expression levels of myeloperoxidase (MPO) and F4/80 were up-regulated in the transplantation group, and the inflammatory cell infiltration was aggravated in the GDF15 knockout transplantation group. Compared with the sham operation group, the expression levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 in the transplantation group were up-regulated. Compared with the wild type transplantation group, the expression levels of TNF-α, IL-1β and IL-6 were also up-regulated in the GDF15 knockout transplantation group (all P<0.05). In the transplantation group, the expression levels of TLR4 and NF-κB in the renal graft tissues were higher than those in the sham operation group. In the GDF15 knockout transplantation group, the expression levels of TLR4 and NF-κB in the renal graft tissues were higher compared with those in the wild type transplantation group. Conclusions GDF15 may alleviate the IRI of renal graft probably via inhibiting the TLR4-NF-κB signaling pathway. [ABSTRACT FROM AUTHOR]

Because of the unique platform advantage, the satellite-based lightning detection in geostationary orbit can continuously obtain the observation information of all lightning activities in a large field of view, which is a new direction for the development of lightning detection technology in the future. LMI (Lightning Mapping Imager) is the first satellite-based Lightning optical imaging observation instrument in China. It is independently developed on the basis of less prior knowledge, and its technical indicators are in the forefront in the world. However, LMI still faces many challenges such as data quality control and verification. For the widely used LMI Level-2 1-minute quantitative Group data (LMIG), according to the coupling relationship between lightning activities and severe weather processes, a multi-level data quality control technology based on multi-source meteorological data is proposed in this paper, through comparison with third-party data, the quality control effect was evaluated and optimized to effectively eliminate the error data and improve the quality of LMI data. The work of this paper provides the basis for the application of LMI data, and it also helps to promote the exploration of satellite-based lightning observation technology and the improvement of instrument performance in China. [ABSTRACT FROM AUTHOR]

Kidney transplantation is more efficacious compared with other organ transplantations. Nevertheless, postoperative complications, such as renal ischemia-reperfusion injury (IRI), severely affect the survival rate and quality of life of recipients. How to mitigate the IRI of renal allografts has become one of the key topics in the field of kidney transplantation. At present, ischemic preconditioning enables renal allografts to adapt to ischemia, which is one of the effective methods to prevent the progression of IRI. However, the underlying mechanism remains elusive. In this article, the application of ischemic preconditioning in IRI, the regulation mechanism of ischemic preconditioning on the IRI of renal allografts at the cellular level and intracellular signaling pathway, and clinical application value and prospect of ischemic preconditioning were reviewed, aiming to provide reference for alleviating the IRI of renal allografts, enhancing the survival rate of the recipients and renal allografts and improving the quality of life of recipients. [ABSTRACT FROM AUTHOR]

Formaldehyde (HCHO) is one of the main pollutants in indoor air, which seriously affects the quality of indoor air and endangers human health. Catalytic oxidation at room temperature is an effective method to remove HCHO, which can completely convert HCHO into C()2 and H2 () at room temperature. However, noble metal catalysts are the main catalysts at present, which are expensive and not conducive to large-scale production and application. Tn this paper, Ti()2 carrier is prepared by sol-gel method, and MnFeO工 is supported by impregnation, evaporation, drying and roasting with manganese nitrate and ferric nitrate as active precursors. Meanwhile, the effects of metal oxide loading, molar ratio, roasting temperature and other factors on the catalytic oxidation performance of catalysts at room temperature are investigated. BET, SEM, XRD, H-TPR, ()2-TPT), in-situ DRIFTS and other techniques are used to characterize and analyze the catalysts. The experimental results show that when MnFeO 工 loading is 1() wt%, n (Mn):, z(Fe)=4:l and calcination temperature is 35() °C, the catalyst exhibits the best catalytic oxidation activity at room temperature, and the removal rate of formaldehyde reaches 87.6 % within 48 h. [ABSTRACT FROM AUTHOR]

With the development of deep learning, cross-modal hashing retrieval methods have made considerable progress. However, current cross-modal hashing retrieval methods are usually based on two hypotheses, a similar pair of texts can have similar images, the images with the same category are globally similar to each other. However, the data in the real-world data set often fails to meet the above two hypotheses, which leads to the decrease of retrieval performance. This paper proposed a TAH. TAH used the text hash code to train the image network, and used the combination of the local and global image features to represent the images. In addition, it proposed the text intra-modality global consistency loss, inter-modality local, global consistency loss and adversarial classification loss to train the cross-modal network. Experiments show that TAH can achieve satisfactory retrieval performance in three data sets. [ABSTRACT FROM AUTHOR]

In recent years, all inorganic lead halide perovskite (CsPbX3) has become one of the most potential optoelectronic materials because of its excellent optical properties and better stability compared with organic-inorganic hybrid perovskite. In this paper, a series of CsPbX3 all inorganic perovskite materials are prepared by supersaturated crystallization method at room temperature, which is simple and easy to operate. The effects of ligands, purification times, reaction temperature, storage time and other factors on the phase, microstructure and luminescent properties are investigated. X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and photoluminescence (PL) are used to characterize the morphology, crystal structure and optical properties of the samples. The results show that pure phase all inorganic CsPbX3 perovskite with high crystallinity, regular morphology and good luminescent properties can be prepared by this method. Through the reasonable control of preparation conditions, such as ligands, purification times and so on, nano materials with good stability at room temperature and air environment can be obtained. This method provides a feasible way to explore the next generation of low-cost and high-efficiency fluorescent materials for optoelectronic devices in the future. [ABSTRACT FROM AUTHOR]

Textile materials especially clothing in close contact with the skin provide a foundation for the transfer of microorganisms from human skin to textiles. Similarly external microorganisms can also transfer to the skin surface by adhering to the textile materials causing skin inflammation infection or allergic reactions. Additionally the growth of microorganisms on textiles can damage the fiber structure or dyes resulting in a decline in strength color fastness or appearance quality. Microorganisms can also decompose sweat oils or other organic substances on textiles leading to unpleasant odors. Therefore antimicrobial textiles have garnered significant attention. Photosensitive antimicrobial agents due to their low biological toxicity do not induce microbial resistance during the antimicrobial process. They can effectively deactivate pathogenic microorganisms and serve as an alternative method to antibiotic chemical therapy with applications in the field of antimicrobial materials. Currently photosensitive antimicrobial agents encompass a variety of compounds mainly including porphyrins heterocyclic anthraquinones thiophene derivatives natural photosensitizers inorganic nano-photosensitive antimicrobials etc. These agents interact with bacteria absorb energy from sunlight and ultraviolet light and subsequently react with oxygen to generate reactive oxygen species that cause oxidative damage to pathogenic microorganisms eliminating bacteria and fungi effectively. Specifically porphyrin-based photosensitizers can generate reactive oxygen species by selectively absorbing specific wavelengths of light thereby killing bacteria and fungi. Bengal rose an anthraquinone-based photosensitive antibacterial agent exhibits excellent biocompatibility. When used as a dye it significantly stains bacterial cells protozoa and tissues. Thiophene derivatives can produce additional intermediate products such as singlet oxygen under specific wavelength of light. Importantly they exhibit minimal toxicity to human normal cells. Photosensitive antimicrobials extracted from plants fungi and bacteria exhibit strong absorption under visible light and exhibit promising photodynamic effects. Inorganic nano-photosensitive antimicrobial agents can activate nanometer materials by light and exhibit antibacterial effects. Their unique electronic physical and morphological properties as well as the arrangement of core-shell hybrid structures offer multifunctionality for antimicrobial applications. The incorporation of these photosensitive antimicrobial agents into fiber or textile materials serves multiple purposes. It not only eradicates bacteria and fungi reduces odors and stains but also effectively prevents the growth of these microorganisms thereby maintaining the cleanliness and hygiene of textiles. Currently the application of photosensitive antibacterial agents on textile materials mainly involves coating method chemical grafting electrostatic adsorption spinning method and so on. Although the coating method is a convenient and quick finishing method textiles treated with coatings exhibit some photosensitive antimicrobial effects the stability is often limited and coatings may age or peel off over time. In order to further enhance the durability of photosensitive antibacterial textile materials chemical grafting is used to covalently bond photosensitizer molecules to textile materials' surface improving the photosensitive antibacterial stability and durability. Electrostatic adsorption involves the electrostatic interaction between charged fibers and ion-type photosensitizers which provides an alternative approach to adsorb photosensitizer molecules onto textile surfaces. Additionally by adding photosensitive antibacterial agents into spinning solutions a special form of electrospinning using polymer fluid can produce fiber materials with photodynamic antibacterial properties. This straightforward technique effectively generates micro / nano-fiber structures thereby increasing surface area and light absorption capacity. At present the application of these photosensitive antimicrobial agents to textile materials still has some limitations. For instance when bacteria viruses and other microorganisms adhere to the textile materials' surface their remnants may persist even after their being killed by photosensitive antimicrobial agents which can affect both the appearance and odor. Research focused on effective removal methods for these microbial remnants is essential. Furthermore investigation is necessary to enhance the durability stability and antimicrobial efficacy of photosensitive antimicrobial textiles particularly after repeated washing. There are numerous effective and high-performance of photosensitive antibacterial agents. Their bactericidal effects are significant and the microbial strains do not develop resistance to them. However further exploration is needed regarding antimicrobial performance biological safety and stability. When the photosensitive antibacterial agents are loaded onto textile materials to achieve high efficiency antibacterial properties the problem of microbial remains on the fabric surface after killing should be carefully considered. Striking a balance between sterilization and decontamination to create a clean textile surface is a key focus in the antimicrobial textiles research. By combining materials with different antimicrobial mechanisms intelligent surfaces which are capable of attracting binding and eliminating various pathogens can be created. This innovation surpasses traditional antimicrobial textiles and expands the application field of photosensitive antimicrobial textiles. [ABSTRACT FROM AUTHOR]

This paper studied problem that the deep descriptors cannot provide the correlation between the features. This paper proposed a feature relevance fusion based deep hashing method to incorporate the relationship between different deep descriptors into the description of the image contents. Firstly, it extracted the feature maps from the pre-trained network and used for deep descriptor generation. Then, it mapped these descriptors to deep visual words, and also explored the frequent item set based on these deep visual words. Next, it concatenated deep visual words based image representation of discrete values and frequent item set based image representation of binary values to represent an image. Finally, it formulated an optimization based on the intra-class and inter-class similarities between images to obtain the optimal thresholds to convert the image representation into a binary string. Extensive experiments show that compared with some state-of-the-art methods, the proposed method can achieve satisfying retrieval performance in the holiday, Oxford and Paris image databases. [ABSTRACT FROM AUTHOR]

Spatial pyramid pooling method integrates spatial information into the generation of deep features based on the convolutional neural network, and the corresponding image representation can effectively enhance the retrieval performance. However, spatial pyramid pooling method causes the information described between the different dimensions in the image representations duplicated and the image contents described by the same dimension unmatched. This paper proposed a multi-scale feature map matching ( MFMM ) based image representation. First, it proposed a feature map selection algorithm which used the variance and covariance matrix of deep features, so as to improve the independence of different dimensions in image representation. Second, according to the characteristic that the high response value positions in the same feature maps of the same channel had higher matching score, it proposed an optimal feature map center selection method based on the deep feature with the maximum response in the activation map. Finally,it extracted deep features with spatial information according to the selected centers and multi-scale windows sampling for representing images. The experimental results demonstrate that the proposed method achieves excellent results in image retrieval tasks. [ABSTRACT FROM AUTHOR]

It lacks of the semantic expression of the mutual effects and interactions between operational entities and geographical entities and geographical phenomena in the existing simulation model of battlefield environment, and consequently, it is hard to reflect the dynamic change rules of the geographic environmental entities under the conditions of time and space. A spatio-temporal process model of battlefield geography environment based on simulation events is proposed to realize the integrated description and structured storage in spatio-temporal process semantics, so as to express the mutual effects and interactions between spatio- temporal objects from semantic perspective. In this model, the ontology method is used to comprehensively describe the spatio -temporal semantics and attribute semantics of simulation events, environmental entities and their behavioral process. Firstly, the spatio -temporal process semantic concepts are abstractly described based on object-oriented method, and the structural conceptual model is established by integrating the semantic relations and semantic operation rules. Secondly, according to the “individual-partwhole” cognitive principle of geospatial, the semantic and logical relationship of spatio -temporal process with hierarchical structure is constructed by top - down method, and semantic constraints are established based on event triggering to standardize semantic operation. Thirdly, the organization and storage structure of spatio-temporal process data is established according to the semantic features of data model, and the dynamic change process of spatio-temporal data driven by simulation event is realized through semantic mapping mechanism. Through the simulation events defined by the simulation system, and the spatiotemporal database and the geographical environment ontology database called by the model association relationship, the semantic attribute record of spatiotemporal process is realized from the data layer, which providing services for spatiotemporal data reasoning and backtracking. The specific performance is as follows: (1) the semantic description of the simulation events is the cause of the change of the environmental entity object; (2) the spatial semantics of the environmental entity objects describe the change information of the spatial location, geometric type and topological relationship of the object; (3) the temporal semantics of the environmental entity objects describe the temporal information of the object during the simulation process; (4) the attribute semantics of the environmental entity objects describe the change information of the object type, structure and function; (5) the process of entity behavior is represented by a series of operations of the attribute semantics of entity objects according to time series. The semantic model of spatio-temporal process is established by ontology as the core, integrating spatio-temporal object semantic information as the core to establish the overall framework of the model, describing and expressing the spatio -temporal semantics simultaneously, to form an object - oriented structure system that conforms to the cognitive law. Compared with the traditional simulation model structure, the dynamic changes of the battlefield geographical environment and the interaction and influence with the simulation events are reflected from the semantic point of view, making the change of spatio-temporal data conform to the development law of battlefield simulation, so the semantic correlation between spatio-temporal data and event information is strengthened by the function, improving the theory and method of dynamic modeling of battlefield environment. In the further work, the dynamic evolution mechanism of spatio-temporal data under the condition of continuous events, the extensibility and reusability of data semantic model, and the application and implementation of the model in complex systems will be further studied and explored to meet the needs of future systems. [ABSTRACT FROM AUTHOR]

Battlefield geographic environment data organization is the important link of battlefield environment information guarantee service, while the well-defined data organizational process model will be beneficial for the smooth implementation of battlefield environment guarantee under joint warfare system. The existing battlefield geographic environment data organizational model lays more emphasis on the description of data status, but lacks of the process model linked with combat task, which is hard to express the causal relationship between data organization and tasks. Owing to the static model of battlefield geographic environment data object by object - oriented method and structural expression, the data organizational process model is established based on object oriented petri net, which generally describing the interaction between data and activities and data storage. Through the application of model in battlefield environment analysis platform, it is approved that the checking of data status, task events and their mutual relationship can be realized effectively. [ABSTRACT FROM AUTHOR]

[Objective] The present paper aimed to get high efficient cellase-producing bacteria and determine the taxonomy. [Method] Sodium carboxymethylcellulose was selected as the sole carbon source to isolate cellulose-producing microorganism. A total of 51 bacteria and actinomyces were isolated from natural fermentation material of tobacco straw.Nine isolates possessed high cellulase activities in congo dye experiment. The phylogenetic relationships of cellulase producing bacteria and actinomyces were determined through the analyses of phylogenetic trees constructed using 16 S rRNA gene sequences. [Result] Luteibacter sp.L43 possessed the highest cellulase activities in enzyme activity tests. The effects of the single factor including pH, carbon and nitrogen concentration on filter paper enzyme, endo-β-1, 4-glucanases and exo-β-1, 4-glucanases for L43 were determined.Under the condition of pH6, sodium carboxymethylcellulose concentration 12.5 g/L and NaNO3 concentration 5 g/L, the highest cellulase activities of endo-β-1, 4-glucanases and exo-β-1, 4-glucanases of L43 were 16.9 and39.62 U/mL, respectively. [Conclusion] This study provided a good cellulose producing bacteria for tobacco straw fermentation and laid a foundation for the development and utilization L43. [ABSTRACT FROM AUTHOR]

Nowadays, with the increasingly coordinated development of regions, the study of population urbanization also urgently needs to be carried out from a broad regional perspective. Focusing on the three core issues of new urbanization, mamely, people, land, and property, the social, spatial, and economic attributes on population mobility are derived. Based on a comparison of the advantages and disadvantages of commonly used data methods in urbanization analysis, this paper constructs a new conceptual model for population urbanization in different scales with multi-source data. Using the census and survey data, mobile phone data, and enterprise registration data, the conceptual model is applied to an empirical study of urban dense areas-Yangzhou city and shows strong applicability, based on migration flow analysis, location identification, and enterprise headquarters- branch network analysis methods. The results show that: (1) At the regional level, due to the factors such as the threshold of settlement, family rights, and social security, population mobility is more cautious than capital flows. And it is compliant with the administrative district economy and urban hierarchy system. (2) At the municipal level, because the central city has greater advantages than the villages and towns, in terms of public service facilities and income levels, the urbanization form is mainly manifested in the direct connection between urban and rural areas, while the radiating and absorbing effects of key towns for population and enterprises are not strong. (3) In the era of ecological civilization, places with beautiful scenery, profound history, and rich cultural heritage are the natural soil for new economy. And the new economy has become a powerful engine for new urbanization in the late-developing areas. Yangzhou has a pleasant ecological environment and profound cultural atmosphere, which is the natural advantage and foundation of developing new types of economy. It needs to develop industrial platform, innovative environment, and innovation system to jointly create a comprehensive advantage of new economic development. Empirical research shows that the conceptual model has good applicability. It can identify the main pattern of economic and social linkages scientifically, reveal the intensive communicating area in town cluster region, and play a supporting role in delimiting urban development boundaries and optimizing the spatial pattern of land. Therefore, this model has a strong reference value for the study of regional coordination of territorial spatial plan at city and county level. [ABSTRACT FROM AUTHOR]

How to provide the targeted effective data rapidly for users according to operational task de- mands is one of the problems that must be solved once battlefield environmental data guarantees to realize active service. Aiming at the complex incidence relation between operational tasks and battlefield environ- ment data, it lacks the methods for the problems such as data matching semantic expression and quantified semantic correlation and semantic weight of different elements at present. Therefore, a calculation method on semantic similarity of battlefield environment elements based on operational task ontology is proposed. The logical relationship of conceptual semantics between operational tasks and battlefield environment data is confirmed with ontology method. The battlefield environment elements are divided according to task se- mantic relevancy, and the semantic similarity calculation is established through adopting the reasoning tech- niques of the combination of rules and cases. Thus we can quantify the entity semantic weight of battlefield environment elements. Experimental results demonstrate the feasibility of this method which can effectively improve the organization efficiency and precision of battlefield environment data. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of phosphoric acid specific transporter 1 (PstS1) protein on peripheral blood single nuclear cells and pleural effusion. Methods The psts1 protein was co-cultured with peripheral blood and pleural effusion single nuclear cells from 35 patient with tuberculous infection and/or complicating tuberculous pleuritis without using immunosuppressor agents conforming to the clinic and/or laboratory diagnosis in the respiration department of the Affiliated Hospital of Zunyi Medical University from Decenber 2015 to December 2017. The control group adopted the fasting venous blood in 20 persons undergoing physical examination extracted by adopting the random sample method. The cellular subsets changes were detected by using the flow cytometry. The secretion situation of cytokines was detected by using ELISA. Results The proportions of CD3+T and CD4+T cells had statistically significantly difference between peripheral blood and pleural effusion (P<0. 05) . The proportion of IFN-γproducing T cells was significantly increased compared with the control group, while the proportions of CD8+T and CD56+CD16+cells were decreased significantly;after PstS1 action, the proliferation ratio of pleural effusion and peripheral blood single nuclear cell was higher than that of the control group, the proliferation ratio of CD4+T and IFN-γproducing T cells was significantly higher than that of the control group. Although the proportion of CD8+T and CD56+CD16 +NK cells was increased, but the difference was not statistically significant (P>0. 05) . The levels of peripheral blood and pleural effusion IL-6, TGF-β, IFN-γand IL-18 in the patients were significantly higher than those in the control group, and the IL-6, TGF-β, IFN-γand IL-18 levels in pleural effusion were higher than those in peripheral blood;after stimulation with PstS1 protein, the levels of IL-18 in culture supernatant fluid, and levels of TGF-β, IFN-γin peripheral blood and pleural fluid were significantly higher than those in the control groups, while the IL-10 and IL-6 levels had no statistical difference compared with the control group (P>0. 05) . Conclusion PstS1 protein can promote the T lymphocyte proliferation, and the local microenvironment difference affect the response of immune cell to PstS1 protein. [ABSTRACT FROM AUTHOR]

The core of military information system adheres to be task-oriented, and the battlefield environment data model is also established surrounding the combat tasks. Aiming at the incomplete battlefield environment information system and the situation that the existing GIS spatio-temporal data models are unable to fully meet battlefield environment spatio-temporal analysis, a kind of task-oriented battlefield environment spatio-temporal data model needs to be constructed. Based on the analysis on few kinds of existing typical spatio-temporal data models, the spatio-temporal data organizing model structure which adapts to battlefield environment is designed through taking data model based on object as theoretical basis and process driven method as modeling mechanism, thus, the maneuverability on complex environment object is realized. Through the application of model in battlefield environment analysis system, it is proved that its task process and geographical spatial data can be described, organized, stored and checked as the object. [ABSTRACT FROM AUTHOR]

Under the frame of oil and gas resources assessment method system, the coal-bed methane(CBM) resources of 41 major basins(basin groups) containing CBM were evaluated by volumetric method. The quality, distribution and availability of CBM resources were analyzed. The results show that the original CBM in-place is 30.05×1012 m-3 in the coal layers with a burial depth of less than 2 000 m, of which 12.50×1012 m-3 is ultimately recoverable. The CBM resources are concentrated in 10 large basins such as Ordos, Qinshui and so on,which account for more than 85% of national CBM resources. Resources are mainly distributed in Upper Palaeozoic and Mesozoic. The quality of resources is average. The main type is type II, followed by type I. There are great differences in the recoverability of CBM and limited areas with good recoverability. Compared with the latest evaluation, the original CBM in-place has decreased by 6.76×1012 m-3, and the recoverable resources have increased by 1.63×1012m-3. It is mainly due to the increased reliability of gas content data and the changes in the understanding of buried depth. The reliable recoverable resources CBM is around 4×1012 m-3 which have the conditions for development by ground technology. Several large basins have priority development conditions, such as Qinshui, Ordos, Eastern Yunnan-Western Guizhou and Junggar. [ABSTRACT FROM AUTHOR]

Objective To investigate the precise effect of Heparin sulfate (HS) on the proliferation, differentiation and mineralization of osteoblasts in vitro. Methods Osteoblasts were isolated from neonatal rat calvaria with enzyme digestion, and HS experimental concentrations were divided into 7 groups (A (0 μg /mL), B (1 μg /mL), C (5 μg /mL), D (10 μg /mL), E (25 μg /mL), F (50 μg /mL) and G (100 μg /mL)). Well-growing osteoblasts were cultured with different HS concentrations in the medium of 2×104 /mL cell suspension. MTT assay was used to detect the cells proliferation at 48h and 96h under different HS concentrations. The AKP activities at 24 h and 48 h were determined by alkaline phosphatase assay kit, quantitative expression of osteogenic markers Collagen I and Runx-2 protein was measured by Western Blot, and the mineralization rates were calculated by alizarin red staining method in 14 days. Results MTT assay showed that HS inhibited the proliferation of osteoblasts at 48 h and 96 h, compared with the control group (P<0.05), which had statistical significance. AKP activity test showed that the osteogenic activities of group E and group F were significantly higher than those in group A at 24 h and 48 h (P<0.05), and the AKP activity of group F was the highest. The Western Blot assay showed that, compared with the control group, the expression of Runx-2 and Collagen I protein increased in the 50 μg/mL HS group at 24 h and 48 h (P<0.05), but decreased in the 100 μg /mL HS group. Mineralized nodules staining showed that different concentrations of HS could promote the formation of mineralized nodules except in group G, group F had the strongest mineralization effect on osteoblasts matrix, and the differences were statistically significant between group A and other effective groups (P<0.05). Conclusion Osteogenic effect of HS is remarkable, and 50 μg/mL HS is the best concentration for the maturation and differentiation of osteoblasts, significantly better than other concentrations. [ABSTRACT FROM AUTHOR]

Spatial clustering is an important tool for spatial data mining and spatial analysis. It is important for the clustering results in many applications to meet the requirement that spatial objects in the same cluster are similar in both the spatial and the attribute domains. To solve the problems of existing methods based on Delaunay triangulation, this paper proposes a spatial clustering method considering uneven distribution of non-spatial attributes. The proposed algorithm involves two main steps: the first is to construct spatial proximity relationships, and the second is to cluster spatial objects with similar attributes. Delaunay triangulation with edge length constraints is first employed to construct spatial proximity relationships among objects. To obtain satisfied results in spatial clustering with attribute similarity, the breadth first traverse (BFT) clustering algorithm is used in accordance with variation rate of attribute to adapt to the local change information of attribute distribution. The performance of the proposed algorithm was evaluated experimentally through comparison with one of the leading state-of-the-art alternatives; multi-constraints algorithm. The results show that our method outperforms the comparative algorithm as attributes are unevenly distributed in space, and provides a quantitative research method in city commercial center extraction. The effectiveness and practicability of the proposed algorithm illustrates three advantages of our algorithm: i) it can reflect the tendency of the entity attribute in the spatial distribution; ii) it can meet the requirement that attributes are unevenly distributed in space; iii) it can discovery clusters with arbitrary shape and is robust to outliers. [ABSTRACT FROM AUTHOR]

Topic dictionary is the descriptive feature subset of topic. A discriminative topic dictionary can decrease feature dimension and improve descriptive accuracy for topic. And then,it will improve the overall performance of topic detection and tracking. Based on the basic mutual information,this paper proposed an objective function to determine the size of original topic dictionary,which was solved by coordinate descent algorithm. Considering news topics dynamic developed with time,this paper put forward a dynamic updating algorithm. Experiments on TDT4 corpus,it adopted miss probability and false alarm probability as evaluation criteria to compare the performance of incremental TF-IDF and the proposed method. Experimental results show that the performance of the proposed method is better. [ABSTRACT FROM AUTHOR]

With the continuous development of deep neural networks, significant progress has been made in the construction of cross-modal retrieval models. Cross-modal retrieval methods based on GCN have shown promising results in capturing semantic correlations in data, thus attracting increasing attention. However, most recent research focuses on incorporating correlations between labels and between samples into cross-modal representations, while the impact of correlations between label sets is neglected. In multi-label scenarios, the correlations between label sets can effectively describe semantic relationships between corresponding samples. Therefore, exploring the multi-label correlations and integrating it into cross-modal representations is important for improving the performance of cross-modal retrieval models. This paper proposed a dual semantic correlation graph convolutional networks(DSCGCN) cross-modal retrieval method. This method utilized GCN to explore the semantic correlations between labels and between multi-labels adaptively, and integrated the learned dual semantic correlations into the common representations. Additionally, it designed a multi-label similarity loss to make the similarities between the common representations more close to the semantic similarities. Experimental results on the NUS-WIDE, MIRFlickr-25K, and MS-COCO datasets demonstrate that because of multi-label correlations, DSCGCN achieves satisfactory retrieval performance. [ABSTRACT FROM AUTHOR]

Background Detaenial sigmoid neobladder reconstruction is a standard treatment method for muscle-invasive bladder cancer and some high-risk superficial bladder cancer. It can effectively increase bladder capacity and reduce surgical complications, and is widely used in clinical practice. Objective To investigate the effect of detaenial sigmoid neobladder reconstruction on perioperative treatment, complications and urinary control in overweight and obese male patients with bladder cancer. Methods The clinical data of 39 patients with bladder cancer who underwent detaenial sigmoid neobladder reconstruction were retrospectively analyzed. According to BMI, the patients were divided into the normal weight group (BMI≤25 kg/m²,15 patients) and the overweight and obese group (BMI ＞ 25 kg/m², 24 patients). The operation time, intraoperative blood loss and postoperative hospital stay of the two groups were recorded. All patients were followed up regularly for 12 months after surgery. Postoperative complications, urinary control ability 6 months after surgery and urinary flow dynamics results 6 months after surgery were observed and recorded in both groups. Results The surgery time in the overweight and obese group (331.45 ± 76.43) minutes was significantly longer than that in the normal weight group (291.67 ± 41.65) minutes, and the difference was statistically significant (P=0.006); There were no significant differences in intraoperative bleeding volume and postoperative hospital stay between the two groups; Six cases (25.0%) of postoperative infections and incision complications occurred in the overweight and obese group, but no postoperative infections or incision complications in the normal weight group, and the difference between two groups was statistically significant (P=0.035); There were no significant differences in the maximum capacity of the new bladder, bladder pressure during filling period, maximum urine flow rate, and residual urine volume between two groups; There were no significant differences in postoperative diurnal and nighttime urinary control rates between two groups. Conclusion Total removal of detaenial sigmoid neobladder reconstruction has the advantages of relatively simple operation, short operation time, few complications, and good urodynamic characteristics of postoperative neobladder for the treatment of overweight and obese patients with bladder cancer. [ABSTRACT FROM AUTHOR]

目的 探讨系统免疫炎症指数 (SII) 对急性心肌梗死 (AMI) 患者新发房颤 (NOAF) 的影响, 并分析其预测 效能. 方法 选择无房颤 (AF) 病史的 AMI患者 234例, 根据入院后是否出现 NOAF 分为 NOAF 组 27例和非 NOAF 组207例. 比较两组SII, 并采用多因素Logistic回归分析确定SII对AMI患者并发NOAF的影响. 绘制SII预测AMI 患者并发 NOAF 的受试者工作特征 (ROC) 曲线, 分析曲线下面积 (AUC)、敏感度和特异度. 结果 NOAF 组和非 NOAF 组 SII分别为 1 580. 7 (984. 5, 2 387. 0)、976. 2 (571. 0, 1 407. 1), 两组比较 P<0. 01. 多因素 Logistic 逐步回归 分析结果显示, SII (OR=1. 001, 95% CI: 1. 001～1. 002, P<0. 01) 是AMI患者发生NOAF的独立危险因素. ROC曲线 分析结果显示, SII预测AMI患者发生NOAF的AUC为0. 72 (95% CI: 0. 613～0. 826, P<0. 01), 敏感度为0. 667, 特异 度为0. 715, 最佳截断值为1 332. 86. 结论 SII升高是AMI患者发生NOAF的独立危险因素, 其对于AMI患者发生 NOAF具有一定的预测价值. [ABSTRACT FROM AUTHOR]

Potato common scab is a common soil-borne disease worldwide, which is caused by Streptomyces spp. In order to screen Bacillus ssp. that may have a good inhibitory effect on scab pathogen, plate antibacterial tests in laboratory were conducted for determination of antibacterial activity, and the phylogenetic tree was constructed for molecular identification of Bacillus species based on gyrB sequence by neighbor joining (NJ) method. The inhibition effect of 13 strains of Bacillus on S. scabies HP4 was detected, and it was found that the inhibition zone diameter of the five strains of BEV2, BAM7, GF3, BPU6 and BMO8 on S. scabies HP4 was greater than 9.0 mm. BEV2 and GF3 were identified as B. velezensis, BAM7 as B. amyloliquefaciens, BPU6 as B. pumilus, and BMO8 as B. mojavensis based on the phylogenetic tree. The antibacterial activity of four strains of Bacillus and their combinations against three pathogenic bacteria were determined. Among them, BEV2+BAM7 had an inhibitory circle diameter of at least (29.5 ± 2.7) mm against pathogenic Streptomyces. When multiple pathogenic Streptomyces appeared simultaneously, it still showed good inhibitory effect, indicating that BEV2+BAM7 have a stable control effect on various potato common scab pathogens. In this experiment, various strains of Bacillus that antagonize different pathogenic Streptomyces are screened, which could expand the antibacterial spectrum against potato common scab and improve the stability of disease prevention and control effects. This may lays the foundation for the biological control of potato common scab and the development of biological agents. [ABSTRACT FROM AUTHOR]

[Objective] This study aimed to explore the links between key soil parameters and soil fungal communities, which will provide reference for the selection of fertilizer and disease control method of tobacco planting. [Method] Soil samples from 7 regions in Yunnan were collected and high-throughput sequencing of the Internal Transcribed Spacer (ITS) was used to analyze and compare the variation characteristics of soil fungal communities in different regions, at different fertility levels, and during different stages (pre-planting stage, rosette stage, vigorous growing stage, mature stage). The relationship between the fungal community structure and soil physicochemical parameters was further discussed. [Result] The soil fungal community composition changed dramatically in different stages, especially between pre-planting stage and the stages after planting. Compared with pre-planting stage, the abundance of Plectosphaerella cucumerina and Cladosporium chasmanthicola reduced significantly after planting tobacco. Genera Alternaria and Fusarium were more abundant during rosette stage and vigorous growing stage, respectively. Moreover, the abundance of Fusarium oxysporum increased significantly during mature stage. In general, Fusarium was the most abundant genus in all stages and all regions, and the number of fungal species in soil was higher in Kunming and lower in Xin-ping all the time. The succession of fungal communities was closely related to labile phosphorus, organic nitrogen and moisture content of the soil. [Conclusion] According to these results, it is suggested that corresponding measures should be taken to control the potential tobacco disease. [ABSTRACT FROM AUTHOR]

[Objective] The study aimed to obtain Bacillus strains with effective control against Rhizoctonia solani, and to clarify the antifungal effect of the secondary metabolites. [Method] An antagonistic Bacillus strain that inhibited R. solani were screened by dual culture in vitro. The strain was identified by morphological characteristics and phylogenetic tree from the alignment sequence of gyrB. The antifungal activity of lipopeptides and volatile organic compounds was determined by the toxic medium method and the double-dish buckle method. In terms of fungal activity of secondary metabolites, specific primers were used to detect the sfp, ituA, fenB, bacD and mycß genes related to the synthesis of five lipopeptide antibiotics in G32, and the types of lipopeptide were analyzed and the fungal activity was determined. Headspace solidphase microextraction (HS-SPME) was used to enrich the volatile organic compounds of G32, two-dimensional gas chromatography-mass spectrometry (GC x GC-MS) was used for substance analysis, and solid medium culture and transparent circle method were used to detect the enzyme-producing activity of strain G32. [Result] A total of 50 strains of Bacillus were isolated from the rhizosphere soil collected from the experimental base of Hebei Agricultural University, and a Bacillus amyloliquefaciens G32 strain with potential biocontrol abilities for potato black scurf were obtained, and the antifungal circle diameter was (20.68±0.42) mm. Morphological and molecular biology identified the strain as B. amyloliquefaciens. Antagonism test showed that the lipopeptide active substances and volatile compounds could inhibit the growth of R solani, and cause mycelium distortion and deformation, vesicles and other conditions. Strains G32 could produce Suffactins, IturinA, BacillomycinD, Mycosubtilin. B. amyloliquefaciens G32 could produce 13 kinds of 6 volatile substances, including ketones, alcohols, aromatics, ethers, organic acids, of which 3-hydroxy-2-butanone content was the highest (48.90%), followed by 2-nonanone (11.33%) and n-octanol (10.84%); Strain G32 had the ability to produce amylase and cellulase. Conclusion] The results demonstrate that strain G32 can produce many antifungal compounds including lipopeptides, VOCs and cellulase. This strain has certain potential application in controlling R. solani. [ABSTRACT FROM AUTHOR]

Renal allograft biopsy (biopsy) remains the "gold standard" for the diagnosis of renal dysfunction after kidney transplantation. Puncture biopsy after kidney transplantation could be divided into indicative biopsy and protocol biopsy according to renal function of the patients. Indicative biopsy is mainly applied to diagnose postoperative complications of kidney transplantation, evaluate the severity of disease and guide subsequent treatment. Protocol biopsy is primarily employed to regular monitor renal allograft function of kidney transplant recipients and exclude subclinical rejection and other complications. Due to the willingness of patients and other reasons, protocol biopsy has not been widely applied in China. Currently, indicative biopsy is the main biopsy pattern. At present, the indications of puncture of indicative biopsy, the timing and necessity of puncture of protocol biopsy remain controversial. In this article, the classification of puncture biopsy after kidney transplantation and research progress on tissue biomarkers based on biopsy were reviewed, aiming to assist clinical diagnosis and targeted treatment of complications after kidney transplantation and provide reference for further improving the survival of renal allografts and recipients. [ABSTRACT FROM AUTHOR]

Objective To analyze Professor Zeng Qingqi’s medication experience and prescription rules in the treatment of premature ejaculation based on the Traditional Chinese Medicine Inheritance Auxiliary System（V3.0）. Methods All medical records of Professor Zeng Qingqi on the treatment of premature ejaculation from the outpatient department were collected and sorted out. By using the association rules and entropy clustering methods of Traditional Chinese Medicine Inheritance Auxiliary System（V3.0）, the drugs and groups in the database were statistically analyzed, and the core clustering formula combinations were mined. Results A total of 100 prescriptions were obtained, including 172 traditional Chinese medicines. In terms of frequency of use, top 10 traditional Chinese medicines were listed as licorice, peony root, atractylodes macrocephala, poria cocos, yam, dried orange peel, raw rehmannia root, dried ginger, angelica root, and chicken cauliflower. The use of the four gases of traditional Chinese medicine was mainly warm drugs, and ive flavors were mainly sweet drugs; 21 core drug pairs were indentified, and 3 new prescriptions were found through unsupervised entropy hierarchical clustering. Conclusion Professor Zeng Qingqi’s treatment prescription on premature ejaculation is mainly based on the method of “tonifying the kidney and strengthening the spleen, calming the heart and soothing the liver”, and the prescription is increased or decreased according to different clinical manifestations of patients. [ABSTRACT FROM AUTHOR]

After the operation of asynchronous interconnection, the sending power system with high-proportion hydropower and multiple DC line delivery has occurred ultra-low frequency oscillation repeatedly thanks to small disturbance instability of AGC system, which threatens the safety of power grids. According to the principles of AGC, the load frequency control model is established for the sending power grid with high-proportion hydropower firstly. The paper analyzes the effect of AGC parameters on small disturbance stability. Furthermore, characteristic damping index is defined as AGC damping performance index and comprehensive objective function is established. The research adopts particle swarm optimization (PSO) algorithm to set PI controller’s parameters. Finally, the simulation results show that the proposed method not only ensures AGC’s frequency modulation performance, but also reduces negative damping greatly provided by AGC to power grid, which is beneficial to restrain ultra-low frequency oscillation caused by AGC. [ABSTRACT FROM AUTHOR]

The experiment was to study the source of uncertainty in determination of molybdenum content in sugarcane molasses by microwave digestion-inductively coupled plasma mass spectrometry, evaluated the uncertainty component was quantitatively. The results showed that the main sources of uncertainty in determination of molybdenum in sugarcane molasses by microwave digestion-inductively coupled plasma mass spectrometry were standard solution preparation and repeatability, and the relative standard uncertainties were 0.011 72 and 0.008 882, respectively. When the average sample weight was 0.520 0 g, the molybdenum content in cane molasses was 0.297 mg/kg, the expanded uncertainty was 0.010 mg/kg, and factor k=2 was included, and the measurement result can be expressed as 0.297 mg/kg. The study indicates that contribution rate of each component of the uncertainty in the determination of molybdenum content in sugarcane molasses is standard product purity and standard curve preparation, repeatability, standard curve fitting, repeatability, digestion solution volume and sample weighing. [ABSTRACT FROM AUTHOR]

The temporal and spatial variation characteristics of threshold value, strength and frequency of extreme high temperature in summer (June to August)of Shanxi Province were calculated and counted by percentile method, and interpolated by the methods of Inverse Distance Weight, Kriging and Anu spline based on the data of daily the maximum temperature from 67 national meteorological observational stations in Shanxi Province from 1971 to 2020. On this base, the comprehensive strength of extreme high temperature was evaluated. The study further analyzed the long term trend of the maximum temperature with the method of Theil Sen, and the mutation test of the maximum temperature was conducted by Mann Kendall test. The study results showed that the threshold values and strength of extreme high temperature were 29.4～37.7 oC and 30.2～38.4 oC respectively with an increase trend from north to south in summer of Shanxi Province from 1971 to 2020. In the past 50 years, frequency of extreme high temperature in summer was 5.8～8.0 d·a－1,which was higher in the southern Shanxi than that in the middle and north of Shanxi and that in the western Shanxi was higher than that in the eastern Shanxi. The comprehensive intensity of extreme high temperature before 1997 and around 2011 was weak, but the amplitude and extremity over⁃ all increased from 1997 to 2011 and from 2011 to 2020. The maximum temperature in most areas of Shanxi Province showed a significant increase trend, with an average rate of 0.3 oC·10 a－1 in summer during 1971－2020. The increase rate of the maximum temperature in the northern, middle and southern Shanxi were 0.3 oC·10 a－1, 0.3 oC·10 a－1 and 0.2 oC·10 a－1,respectively. The maximum temperature change abruptly in late 1990 s in the north and center of Shanxi, and the mutation occurred around the year of 2000 in southern Shanxi Province. The study results are of great significance to the prediction of extreme high temperature, impact assessment and the proposal of countermeasure in Shanxi Province, North China and the whole country in the future. [ABSTRACT FROM AUTHOR]

In order to enrich the data on genome sizes of Polygonatum species, flow cytometry was used for ploidy detection and estimation of genome sizes of four Polygonatum species recorded in the Chinese Pharmacopoeia, including P. kingianum, P. sibiricum, P. cyrtonema, and P. odoratum from different habitats. The results show that Phyllostachys pubescens can be used as a suitable reference standard for the estimation of genome sizes of Polygonatum species. Regarding the four diploid Polygonatum species, the present study found that the genome size of P. odoratum（13 829-14 083 Mb） is similar to that of P. kingianum（13 780 Mb); the genome size of P. sibiricum（12 792-13 516 Mb） is slightly smaller than that of P. odoratum and P. kingianum; and the genome size of P. cyrtonema（9 311 Mb） is the smallest. The genome size of triploid P. cyrtonema is 11 032-11 267 Mb, which is 1.2 times larger than that of diploid P. cyrtonema. The genome size of tetraploid P. kingianum is 12 088-12 411 Mb, which is 89% of the size of diploid P. kingianum. The results append the data on the genome sizes of Polygonatum species, which will provide a reference for a follow-up study on genomics, species classification, and population evolution. [ABSTRACT FROM AUTHOR]

BACKGROUND: Human bone marrow mesenchymal stem cells have the phenomenon of cell aging during passage in vitro, but the mechanism by which it occurs is not yet clear. Aldehyde dehydrogenase 3B1 has antioxidant effect. Oxidative stress is one of the important factors leading to cell senescence. Whether the expression level of aldehyde dehydrogenase 3B1 is related to human bone marrow mesenchymal stem cells senescence is still unclear. OBJECTIVE: To observe the expression of aldehyde dehydrogenase 3B1 in cellular senescence, providing a new research direction for aging mechanism of stem cells. METHODS: The natural senescent model of human bone marrow mesenchymal stem cells was established and identified. The mRNA expression of aldehyde dehydrogenase 3B1 in human bone marrow mesenchymal stem cells was detected by bisulfite methylation sequencing and real-time qPCR. The protein level of aldehyde dehydrogenase 3B1 was detected by immunofluorescence and western blot assay. RESULTS AND CONCLUSION: (1) Human bone marrow mesenchymal stem cells were cultured in subculture. β-Galactosidase staining showed that positive cells increased continuously, and the positive cells were the most obvious at passage 7 to 13. (2) Methylation sequencing showed that in passage 16 human bone marrow mesenchymal stem cells, the methylation level of aldehyde dehydrogenase 3B1 was down regulated. (3) The mRNA and protein levels of aldehyde dehydrogenase 3B1 were down regulated during the passage of human bone marrow mesenchymal stem cells in vitro. (4) The results show that aldehyde dehydrogenase 3B1 is down regulated in the natural senescence of human bone marrow mesenchymal stem cells, but its mechanism needs further study. [ABSTRACT FROM AUTHOR]

Objectives：With the increasing application of urban three‐dimensional scenes, the huge amount of three‐dimensional building model data has brought tremendous pressure to the storage, display, transmission and real‐time rendering of the computer. On the premise of ensuring the quality of Web 3D display, moderately simplifying of the three‐dimensional model is an effective way to relieve the pressure on computer. Methods: To reduce the visual degradation caused by the loss of detail features and the degradation of mesh quality when the three‐dimensional building models are simplified to a lower resolution, a simplification algorithm for three‐dimensional building mesh model was proposed based on angle error in this article. Results: The vertex constraint was considered in the selection of contractible edges, and the rotation direction of new faces was controlled based on angle error, thereby improving the error metrics of vertices in the feature region of the model. Conclusions: The experimental results show that the proposed algorithm can effectively preserve the geometric features of the building model and reduce the number of elements drawn by the system with acceleration strategies such as in‐core and out‐of‐core exchange, view frustum culling and occlusion culling. [ABSTRACT FROM AUTHOR]

[ Objective] The present paper aimed to obtain antagonistic Bacillus strain which showed strong activity against Alternaria solani in potato, and the effect of the active substances by this strain on potato early blight was evaluated. [ Method] Biological bacteria isolated from potato rhizosphere soil was screened using plate confrontation method. By analysis of the morphological characteristics, physiological and bio chemical indexesand gyrB sequence, the effects of the strain with significant antifungal on pathogen was identified. High penormance liquid chromatography ( HPLC) was used to determine the active components of fermentation broth of biological strain. [ Result] Biological bacteri um against A. solani was identified as Bacillus velezensis Cl 6. Strain C16 was able to secrete amylase and sunactinand had the ability of ni trogen fixation, the fermentation broth and lipopeptide extract of strain C16 could significantly inhibit the mycelial growth of A. solani, and the inhibition zone of fermentation broth and 10 mg/mL lipopeptide extract were 31. 50 and 12. 67 mm, respectively. Using scanning electron microscopy ( SEM), the deformed hyphae of A. solani co-cultured with fermentation broth and lipopeptide extract were observed, meanwhile, the treated hyphae also appeared with wrinkles and vesicles in sunace. By HPLC, Sunactin and lturin were identified as the main com pounds in C16 lipopeptides. Among them, lturin showed a strong inhibitory effect on A. solani mycelial growth. [Conclusion] In this study, B. velezensis Cl6 showed great biological ability against A. solani in potato. lturin was the major antifungal substance in lipopeptides pro duced by strain C16. This study could provide a candidate strain resource for the development of microbial agents to control potato early blight and lay a foundation for development and utilization of strain C16. [ABSTRACT FROM AUTHOR]

Objective To investigate the different-dose effects of methamphetamine (METH) on spatial learning and memory and the possible mechanisms. Methods C57BL/6 mice were treated with 0.5, 1.0 and 2.0 mg/kg of METH or normal saline. The drug was injected intraperitoneally 30min prior to the Morris water maze. All mice experienced 5 consecutive days’ positioning navigation experiment and the spatial exploration experiment conducted 24 hours after the last training trial. Immediately after the probe test, the mice were killed by cervical dislocation and the hippocampus was dissected. Western blot was used to detect changes in phosphorylation levels of extracellular signal-regulated kinase (ERK1/2) and cAMP response element-binding protein (CREB) in the hippocampus. Results Compared with the mice in saline group, those in 1.0mg/kg METH group had a significantly shorter latency (P<0.05), spent more time in the target quadrant (P<0.05), and had more platform site crossings (P<0.05). Moreover, 0.5 and 2.0mg/kg of METH did not significantly affect the mice's spatial learning and memory, but 0.5mg/kg of METH showed a memory-promoting trend, while 2.0mg/kg of METH showed a memory-destroying trend. METH of 1.0mg/kg significantly increased p-ERK1/2 (P<0.05) and p-CREB (P<0.05) levels in the hippocampus. Conclusion METH of 1.0mg/kg significantly improved mice's spatial learning and memory. The effect of METH is an inverted U-curve among three doses of METH at 0.5, 1.0 and 2.0mg/kg. ERK1/2 and CREB in the hippocampus may be involved in METH-induced improvement of spatial learning and memory in mice. [ABSTRACT FROM AUTHOR]

In order to improve the adsorption performance of activated carbon, the activated carbon was modified by thiourea solution under ultrasonic assisted conditions. The effect of gold adsorption under different modification and adsorption conditions was investigated. Field emission scanning electron microscopy (SEM) and Fourier infrared spectrometer (FTIR) were used to characterize pore structure and surface properties of activated carbon before and after modification. The results shows that the optimal modification condition was thiourea solution of 3 mol/L, temperature of 95-100 °C , time of 3 h, suitable pH value of the adsorption environment of 2-2.5, modified carbon added of 0.5 g, and adsorption time of 1.5 h. Under the toptimal modification condition, the adsorption rate reached 97%. According to the characterization, the activated pore structure of activated carbon was obvious? and the specific surface area increased. The addition of thiourea changed the spectral peaks of the original group, and new groups such as —NH2, C=O, C— H, and C=S were formed to enhance the adsorption of carbon. The adsorption isotherm of the modified charcoal accorded with the Langmuir and Freundli-ch isotherm model? showing that the adsorption mode of the modified charcoal was the adsorption mode in which monolayer adsorption dominated with multilayer adsorption. The saturated adsorption capacity after fitting was 0.208 mmol/g and the actual saturated adsorption capacity was (0.194 mmol/g), showing the better adsorption effect [ABSTRACT FROM AUTHOR]

Objective To analyze patients with diabetes in health management of Malu Town Community Health Service Center with different types of cost and cost of health care, and to understand the treatment distribution and medical insurance cost of patients with diabetes. Methods Totally 3 280 patients with diabetes health management at the end of 2015 in Malu Town Community Health Service Center were enrolled as the research object. The distribution of medical treatment and the cost o medical insurance cost were analyzed in 2012—2015. Results Patients with diabetic disease were mainly outpatient clinic, and were mainly reimbursed by Western medicine expense. Meanwhile die test fees and medicine expense of patients were relatively small. The highest cost of health care for diabetes was still the cost of health care outpatient fee, showing a rapid upward trend. Conclusion The cost of patients with diabetes is mainly spent on Western medicine,showing a rapid upward trend year by year,which is mainly outpatient clinic. [ABSTRACT FROM AUTHOR]

As a key tectonic regime of the subduction and closure of Paleo-Tethys Ocean, the West Kunlun orogenic belt has great significance in the study on the tectonic-thermal history of Paleo-Tethys Ocean. Moreover, it has close connection with the tectonic and climatic evolution of Tibetan Plateau and Tarim Basin. In order to reveal the evolution history of Muztag pluton in the northwest section of West Kunlun orogenic belt, several isotopic characteristics of zircon U-Pb ages and biotite 40Ar-39Ar ages of melanocratic enclaves hosted in it were discussed. The zircon U-Pb isotopic analysis returns a weighted average U-Pb age of (218.8±1.9)Ma, which is interpreted as the crystallization age of the pluton. Combined with regional geological data, it is inferred that Muztag pluton emplaces in an extensional regime related to the post-collisional setting following the closure of Paleo-Tethys Ocean. Biotite 40Ar-39Ar isotopic analysis yields the plateau ages of (6.018±0.072)Ma and (5.675±0.059)Ma, respectively, which are considered as uplifting and cooling ages of the pluton, indicating that West Kunlun area undergoes a cooling-uplift event in Late Miocene. The event vehemently changes the tectonics, topography and geomorphology of West Kunlun and its adjacent area, gives rise to a regional arid climate, and impels the formation of Taklimakan Desert in Tarim Basin. [ABSTRACT FROM AUTHOR]

Point pattern matching (PPM) is an important issue in computer vision and pattern recognition，such as target recognition, medical and remote image registration， and pose estimation， and so on. We propose a novel PPM algorithm based on point features. We first construct feature attribute im­age of the points according to the distribution of point sets and points' position. Then polar coordinate transform is applied to the feature attribute image, and we describe the feature attribute image with the moment invariants. We get the course matching results by comparing the feature vectors, and an iterative method is introduced for the final matching. We make two contributions in this paper. Firstly, we construct a polar coordinate transform based points features, and describe the features with the moment invariants. The features are invariant to rotation and transportation. Secondly， an iterative matching process by point features and geometry constraint is proposed. The method is insensitive to outliers and noises. Experimental results demonstrate the validity and robustness of the algorithm. [ABSTRACT FROM AUTHOR]

Objective To observe the efficacy of thrombus aspiration and tirofiban injection in the infarct-related artery (IRA) during primary percutaneous coronary intervention (PCI) for patients with ST-elevation acute myocardial infarction (STEMI). Methods A total of 180 STEMI patients were randomly divided into three groups, 60 cases in each group: group A which received the IRA thrombus aspiration and tirofiban injection+PCI, group B which received IRA thrombus aspiration +PCI and group C treated with PCI. The color Doppler ultrasound examination was performed at 1 day and 1 year after PCI to observe the left ventricular end systolic volume index (LVESVI) , left ventricular end diastolic volume index (LVEDVI), left ventricular ejection fraction (LVEF) and ventricular remodeling. Hemorrhage events in a week and the cardiovascular events in a year among three groups were compared. Results After 1-year follow-up of 175 cases, 1 case in the group A died of cardiac rupture on the fifth day after PCI; 2 cases in the group B and 2 cases in the group C died of sudden cardiac death in one year after PCI. One year after operation, LVEDVI and LVESVI were decreased, LVEF was increased in the group A as compared with those of the group B and group C (all P<0.05); the ventricular remodeling was found in 4 cases (6.7%) of group A, 12 cases (20.6%) in the group B and 17 cases (29.3%) in the group C, and the remodeling rate of group A was lower than those of group B and group C (all P<0.05); in the group A, angina recurrence occurred in 3 cases, cardiac insufficiency was found in 2 cases, sudden cardiac death was found in 1 case, and the incidence of adverse cardiovascular events was 10.1%, in the group B, they were 7, 5, 2 cases and 24.1%, respectively, 9, 8, 2 cases and 32.7% in the group C, respectively, and the incidence of adverse cardiovascular events of group A was lower than that of group B and group C (all P<0.05). One week after operation in the three groups, the mild bleeding was found in the skin, mucous membrane, puncture sites and gingiva, but no massive hemorrhage or severe bleeding occurred, and no significant difference was found in bleeding among these three groups (all P>0.05). Conclusion Thrombus aspiration and tirofiban injection in the IRA during PCI can reduce ventricular remodeling of STEMI patients, improve the cardiac function, reduce the occurrence of cardiovascular events and do not increase the risk of hemorrhage. [ABSTRACT FROM AUTHOR]

随着肺炎链球菌（ＳＰ）耐药菌株的不断出现使得疫苗研发备受关注，但目前使用的荚膜多糖及其结合疫 苗有很大局限性。因此，针对ＳＰ主要毒力因子的蛋白质疫苗迅速发展，其中ＳＰ单一蛋白质疫苗包括溶血素、表面 蛋白Ａ、表面黏附素Ａ、三组氨酸蛋白Ｄ、黏附毒力因子Ａ，蛋白质联合疫苗包括多价重组蛋白质联合疫苗、多价蛋 白质融合疫苗，已取得一定实验和临床效果，有望替代多糖疫苗。 [ABSTRACT FROM AUTHOR]

目的：通过检测不明原因复发性自然流产（URSA）患者血清中人胸腺活化调节趋化因子17（CCL17）与CC趋化因子受体4（CCR4）的表达水平，探讨其与URSA的关系。方法选取健康早孕女性（HEP组）、健康未孕女性（HNP组）和URSA孕妇（URSA组）各50例。采用ELISA法检测3组血清CCL17和CCR4水平，同时随防至妊娠结束。结果 HEP组CCL17、CCR4水平高于URSA组和HNP组，URSA组CCL17、CCR4水平高于HNP组（P均＜0．05）；流产次数2次者CCL17、CCR4表达水平高于≥3次者（P＜0．05）。随访发现，URSA组的自然流产率为96．0％，HEP组为4．0％，两组自然流产率比较差异有统计学意义（χ2＝81．03，P＜0．05）。结论 URSA患者血清中CCL17、CCR4水平降低。其水平降低可能导致了自然流产。 [ABSTRACT FROM AUTHOR]