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目的　观察达格列净对中青年2型糖尿病（T2DM）合并非酒精性脂肪肝（NAFLD）的改善作用。方法　选 取口服降糖药治疗不达标的中青年T2DM合并NAFLD患者40例，在维持原降糖方案基础上，加用达格列净口服20 周。患者分别于治疗前、治疗20周时行腹部定量CT检查，测量肝脏脂肪含量、腹部内脏和皮下脂肪面积，采用FIB-4 指数评估肝纤维化，同时检测代谢指标、超敏 C 反应蛋白（hs-CRP）、白细胞介素 6（IL-6），计算胰岛素抵抗指数 （HOMA-IR）及胰岛β细胞功能指数（HOMA-β）。结果　与治疗前比较，治疗后患者肝脏脂肪含量、谷丙转氨酶、谷 草转氨酶、γ-谷氨酰转肽酶、hs-CRP、IL-6、体质量、BMI、内脏脂肪面积、皮下脂肪面积、空腹血糖、糖化血红蛋白、 HOMA-IR、血压、甘油三酯、总胆固醇、低密度脂蛋白、尿酸、尿微量白蛋白/肌酐显著下降，HOMA-β显著升高（P均< 0. 05）。结论　达格列净对中青年T2DM合并NAFLD有改善作用，其不仅可以降糖、减重、改善胰岛功能、减轻胰岛 素抵抗、改善代谢综合征，还能降低肝脏脂肪含量、肝酶、血清炎症因子水平，改善脂肪肝。 [ABSTRACT FROM AUTHOR]

The discovery of marginal ore body in Fankou lead-zinc mine makes the current filling system of the mine unable to meet the increasing demand of backfilling. According to the position of the newly proved ore bodies and the filling stations in Fankou, this paper puts forward two kinds of pipeline layout schemes: the construction of new filling boreholes and the use of original filling boreholes. The maximum allowable stowing gradients of graded tailings and fine tailings transported by ground filling pipeline are calculated to be 8. 56 and 3. 47. According to the theoretical calculation and numerical simulation results, it is considered that when the graded tailings and fine tailings are transported at the surface stage of filling pipeline, both schemes need to be transported by pumping. In the underground stage of filling pipeline, the graded tailings filling slurry can be transported by flow. When the filling times line drops below 3, fine tailings can be transported by flow. The calculation results of pumping pressure show that the filling system needs to be equipped with a filling pump with the maximum pumping capacity of not less than 12 MPa to meet the demand of filling slurry transportation in the mine. [ABSTRACT FROM AUTHOR]