Against the background of the increasing separation of natural and human geography, gradual disintegration of the comprehensive disciplinary characteristics of geography, and weakening of the social influence of geographers, the domestic geography community has recently been discussing the possibility of integrating natural and human geography and the possible paths for doing so. In response, this study proposes an analysis framework of Ecological Economic Geography conducive to the integration of physical and human geography. Furthermore, this study advocates a focus on the dynamic change of "human" as a giant system with complex links of economy, technology, and institutional systems, and its two-way feedback relationship with the ecosystem. By exploring the coupling and regulation mechanisms of human and natural systems in the context of environmental and technological change, this study seeks the best answer to human sustainable development in the comprehensive balance. To clarify the research perspective and ideas of Ecological Economic Geography, we select the following three cases: i) the centennial evolution of the ecological economic system of Mulberry-dyke and Fish-pond System, ii) the systematic cascade of the "digital-energy-water" in data centers, and iii) the humanistic perspective of ecological restoration planning. With a focus on the analytical framework of the "pattern-process-relationship-pathway, " this study proposes four research topics on which Ecological Economic Geography needs to focus, specifically, the coupling pattern of ecosystems and economic systems, process and impact of different factor flows between different systems, regional complexity of ecological and economic coupling systems, and sustainable development pathway of the ecological economic system. Accordingly, the development of Ecological Economic Geography may strengthen the mutual collaboration between scholars of the natural world and the humanities, promote the integration of geographic disciplines, and enhance the ability of geography to solve extensive problems. [ABSTRACT FROM AUTHOR]