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基于数据驱动的方法在电力系统暂态稳定评估的效率和精度提升上已经取得了一些研究成果。然而电力系统暂态过程中涉及多维度时序特征的变化，常规算法对特征的提取能力不足且缺乏可解释性，难以反映系统暂态过程中的动态行为。因此，构建了一个具有双塔结构的Transformer模型，以Transformer编码器作为特征提取器，考虑同一时刻不同维度的特征以及每一维度特征在不同时间步对系统暂态稳定的影响，并将其分别作为双塔结构Transformer模型的输入，训练和学习各特征通道和时间步对系统暂态稳定性的影响。通过融合机制，建立了由系统特征到系统稳定性的端到端的映射模型，实现了暂态稳定高精度的评估，并通过注意力热图可视化解释模型的决策过程。最后，在IEEE-39节点系统验证了所提方法的有效性。

Copyright of Chinese Journal of Inorganic Analytical Chemistry / Zhongguo Wuji Fenxi Huaxue is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Anhui Agricultural Sciences is the property of Journal of Anhui Agricultural Sciences Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of New Perspectives in Translation Studies is the property of New Perspectives in Translation Studies Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To observe the effect of moxibustion on the Young's modulus of lumbar muscle groups, hind limb gait parameters, and bone mineral density in ovariectomized rats, and to explore the role of moxibustion in improving muscle function in ovariectomized rats based on the theory of musculoskeletal interaction. Methods Thirty-two SD rats were randomly divided into 4 groups: sham operation group, model group, moxibustion group, and estrogen group, with 8 rats in each group. Rats in the model group, moxibustion group, and estrogen group were ovariectomized. The acupoints of the moxibustion group were taken from both sides of the Liver-Yu and Kidney- Yu for 15 minutes each time, once every other day, 3 times a week for a total of 12 weeks. After the intervention, real-time shear wave ultrasound elastography (SWE) was used to determine the Young's modulus of lumbar muscle groups in rats. The gait analysis system WalkAnalysator VTX recorded the support duration (s), swing duration (s), swing speed (cm/s), and stride width (cm) of the hind limb. Micro-CT was used to detect bone mineral density (BMD), bone volume fraction (BV/TV), trabecular bone thickness (Tb.Th), and trabecular bone separation (Tb.Sp) in the right femur. Results Compared to those in the sham operation group, the Young's modulus in lumbar muscle group decreased (P<0.01), the support duration, swing duration, and step width of hind limbs increased (P<0.05, P<0.01), the swing speed decreased (P<0.01), BMD, Tb.Th, and BV/TV of the right femur decreased (P<0.01), and the Tb.Sp increased (P<0.01). Compared to those in the model group, the Young's modulus of lumbar muscle group in the moxibustion group and estrogen group increased (P<0.05), the hindlimb support duration, swing duration, and step width shortened (P<0.05, P<0.01), the swing speed increased (P<0.01), BMD, Tb.Th, and BV/TV of the right femur increased (P<0.01), and the Tb.Sp decreased (P<0.01). Conclusion Moxibustion Liver-Yu and Kidney-Yu increases the Young's modulus value of lumbar muscle groups in ovariectomized rats, affects the gait parameters of hind limbs, thereby improving muscle function and improving BMD. This provides a traditional Chinese medicine solution for the prevention and treatment of osteoporosis from the perspective of musculoskeletal interaction. [ABSTRACT FROM AUTHOR]

Copyright of Mycosystema is the property of Mycosystema Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Cancer Research on Prevention & Treatment is the property of Cancer Research on Prevention & Treatment Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In the new round of land spatial system planning and reconstruction, a top-down land spatial planning system has gradually been established. Village planning is an important component of the national spatial planning system and an important lever for rural revitalization. However, there are still some shortcomings in the completed village planning results. In order to improve village planning, this article used a linear regression model to conduct a significance analysis on 127 samples selected from the completed "multi planning and integration practical village planning" in Qujing City. The main influencing factors and their weights that affected the results of practical village planning were identified. The results showed that factors such as construction land scale, homestead area, and conflicts between the "three districts and three lines" had a greater impact on the weight, and these indicators were more in line with relevant policy regulations, the more reasonable the village planning is; the impact weight of village classification and positioning, industrial development direction, and other indicators was relatively small. The closer these indicators were to reality, the stronger the practicality and feasibility of village planning. Based on the analysis results, targeted measures are proposed to improve village planning from four aspects: policy, talent, funding, and publicity, providing experience for other unfinished areas and strengthening the guidance of rural revitalization planning, so as to consolidate the foundation for better rural revitalization and socialist modernization. [ABSTRACT FROM AUTHOR]

Based on the core idea that environment, health and disease are closely related at the molecular level, developmental origins of health and disease (DOHaD) aims to provide a new perspective for the relationship between health and disease, and to trace back how different life experiences affect the risks for health and disease in the whole life process through expertise from multiple disciplines and fields. The developmental critical windows and sensitive periods of adult diseases is no longer limited to pre -pregnancy and pregnancy, the period from delivery to early adulthood has also become an important period of exposure factors. Maternal/paternal factors, environmental factors, neonatal birth status, childhood metabolism and many other influencing factors can change the development process and show positive or negative effects on the long-term health of offspring with different mechanisms, including epigenetics, regulation of metabolism, immunity and oxidative stress. Therefore, for the aim of health promotion, the prevention, the follow-up and simultaneous health intervention of early stage of life should be put a premium stage, in order to reduce the risk of adult diseases and improve full life -cycle health level effectively. Summarizing the latest research progress in the field of DOHaD is of great significance to clarify the impact of adverse events in the early stage of human development on health and disease patterns and find useful interventions. [ABSTRACT FROM AUTHOR]

Copyright of China Mechanical Engineering is the property of Editorial Board of China Mechanical Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Mental Health Journal / Zhongguo Xinli Weisheng Zazhi is the property of Chinese Mental Health Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Transcription factors are a class of proteins that regulate gene expression in cells by directing RNA polymerases to bind to specific DNA sequences. Transcription factors, as important regulatory proteins for prokaryotes to adapt to the natural environment, can specifically sense ligand molecules in environmental media. By coupling with different signal transduction and amplification systems, biosensing systems with transcription factors as recognition elements can construct flexible sensing strategies in whole-cell system, cell-free system and in vitro reaction systems. The transcription factor-based biosensors（TFBBs）have the advantages of high sensitivity, small size, low-cost, and on-site monitoring, showing great potential in the analysis of environmental pollutants. This paper introduces the reaction system types, core component compositions and working principle of TFBBs, as well as lists their application progress in the detection of environmental pollutants including heavy metal ions, aromatic compounds and antibiotics. On this basis, the opportunities and challenges for TFBBs in the detection of environmental pollutants are discussed, and the development trend of TFBBs is prospected. It points out that the rapid development of interdisciplinary emerging technologies such as synthetic biology and artificial intelligence will promote the artificial design and sensing performance improvement of TFBBs, making them applicable in a wider range of fields. [ABSTRACT FROM AUTHOR]

Copyright of Industrial Water Treatment is the property of CNOOC Tianjin Chemical Research & Design Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the effects and mechanisms involved in glioma conditioned medium for inducing glycolysis and oncogenic mediators in macrophages. Methods Bone marrow derived macrophage (BMDM) induced by hypoxia and mouse glioma cell line GL261 conditioned medium (GCM)(GCM-BMDM) were used as a model. The mRNA level of M1 and M2 oncogenic mediators, hypoxia-inducible factor-1α (HIF-1α) and glycolysis associated genes in GCM-BMDM were detected by qPCR. The extracellular acidification rate (ECAR) of GCM-BMDM was detected by Seahorse bioenergy assay method. The protein levels of signal transducer and activator of transcription 6 (STAT6), signal transducer and activator of transcription 3(STAT3) and their phosphorylated forms p-STAT6 and p-STAT3 were examined by Western blot. Results GCM stimulated mRNA expression of Hif-1α and a variety of M1 and M2 oncogenic mediators in BMDM (P＜0.01). GCM upregulated the mRNA expression of multiple glycolysis associated genes (P＜0.01) and increased glycolysis level in BMDM (P＜0.001). The glycolysis level was reduced by incubation with lactate dehydrogenase inhibitor stiripentol (STP) (P＜0.05). STP down-regulated mRNA levels of Hif-1α and oncogenic mediators Il-1β, Il-6, Ido and Cd163 in GCM-BMDM(P＜0.01). STP decreased the ratio of p-STAT3 /STAT3 and p-STAT6 /STAT6 in GCM-BMDM (P＜0.05). Conclusions GCM increases glycolysis level and induces the pro-tumoral phenotypes in GAMs through promoting transcriptional regulation mediated by HIF-1α, STAT3 and STAT6. STP can effectively reduce glycolysis and transcriptional expression of oncogenic mediators in GAMs. [ABSTRACT FROM AUTHOR]

Copyright of e-Education Research is the property of Northwest Normal University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shanghai Ocean University is the property of Editorial Department of Journal of Shanghai Ocean University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Biotechnology Bulletin is the property of Biotechnology Bulletin Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shanghai Jiao Tong University (1006-2467) is the property of Journal of Shanghai Jiao Tong University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Basic & Clinical Medicine is the property of Editorial Office of Basic & Clinical Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Wildlife / Yesheng Dongwu Xuebao is the property of Chinese Journal of Wildlife Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Based on the comprehensive review and systematic analysis of the integrated water regulation for 24 years, combining the scheduling implementation, hydrological test data, statistical yearbook data and scientific research results, a qualitative and quantitative statistical analysis approach and a multi-scale nested method were adopted to objectively and comprehensively evaluate the integrated water regulation in terms of hydraulic connectivity of the river, ecological environment improvement, balanced water security and industrial structure optimization. On the basis of the analysis and summary of the problems of increased difficulty in scheduling, insufficient water conservation capacity and outstanding contradiction between supply and demand in water dispatching, this study proposed suggestions and countermeasures for sustainable development of the basin at this stage from the three levels of outlook of water distribution, water conservation and water transfer to provide scientific guidance for ecological protection and high-quality development of the Yellow River. [ABSTRACT FROM AUTHOR]

Copyright of Food & Machinery is the property of Food & Machinery Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Nanjing University of Information Science & Technology (Natural Science Edition) / Nanjing Xinxi Gongcheng Daxue Xuebao (ziran kexue ban) is the property of Editorial Office of Journal of Nanjing University of Information Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To compare the perioperative risk factors and postoperative efficacy of πcraniectomy plus orthopedic helmet versus cranial vault remodeling for non-syndromic premature sagittal suture and examine the advantages and disadvantages of two treatments to provide references for formulating individualized treatment plans for infantile non-syndromic sagittal premature closure. Methods From May 2018 to May 2023, retrospective review was conducted for hospitalized infants with non-syndromic sagittal premature closure.Perioperative data, perioperative cephalic index and intracranial volume were statistically examined.T test was utilized for normal distribution data and Mann-Whitney test for non-normal distribution data.P < 0.05 implied statistically significant inter-group difference. Results There were 11 children (8 boys, 3 girls) in π craniectomy plus orthopedic helmet group.Cranial vault remodeling group included 6 children (4 boys, 2 girls).No significant inter-group difference existed in pericephalic index or preoperative intracranial volume (P>0.05).Preoperative cephalic index [(0.72±0.06) vs.(0.67±0.04)], postoperative cephalic index [(0.77±0.06) vs.(0.73±0.01)]and preoperative intracranial volume [(753.54±94.25) vs.(812.02±79.89) ml].However, differences of statistical significance existed in age [(8.23±2.10) vs.(14.57±5.54) month], operation duration[(2.24±0.22) vs.(5.00±0.52) h], intraoperative volume of blood loss [(70.0(57.5, 122.5) vs.120.0(100.0, 127.5) mL], hospitalization expense [31355.0(27595.0, 37554.0) vs.116414.5(98185.3, 124383.5) yuan]and postoperative follow-up intracranial volume [(823.72±93.94) vs.956.54±149.31) mL](P < 0.05). Conclusions Both πcraniectomy plus orthopedic helmet and cranial vault remodeling may improve intracranial volume and cephalic index of infants with non-syndromic premature sagittal suture.However, π craniectomy plus orthopedic helmet offers the advantages of shorter operative duration, less intraoperative volume of hemorrhage and lower hospitalization expense.Cranial vault remodeling is reserved for postoperative expansion of intracranial volume. [ABSTRACT FROM AUTHOR]

Copyright of West China Journal of Stomatology is the property of Sichuan University, West China College of Stomatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Science & Biotechnology is the property of Journal of Food Science & Biotechnology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Basic & Clinical Medicine is the property of Editorial Office of Basic & Clinical Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Novel modified silica nanoparticles, polyaniline and polypyrrole with controllable structure and properties were synthesized as functional materials, and four thin-film microextractionmembranes were prepared by spreading and the HPLC characteristic chromatograms of Guben Yanling Pills were established by thin-film microextraction coupled with HPLC. Fourier transform infrared spectroscopy and scanning electron microscope were used to characterize the chemical structure and surface morphology of the films. The main factors affecting the extraction efficiency, such as extraction time, ionic strength and desorption time, were optimized.20 batches of Guben Yanling Pills were analyzed, and 10 common peaks were determined under the optimum extraction conditions. After comparison with the reference substances, the peaks 4,5,6,8 were identified asechinacoside, verbascoside, liquiritin and salvianolic acid B, respectively. The results showed that the method was simple, reliable and green. It is applicable to the quality analysis of Guben Yanling Pills. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Inorganic Analytical Chemistry / Zhongguo Wuji Fenxi Huaxue is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Light Industry Machinery is the property of Light Industry Machinery Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In the context of the Internet of Vehicles, traditional resource access control techniques are inefficient and present security risks. Therefore, this paper proposed an innovative resource access control solution based on a multi-strategy access tree algorithm. This solution improved the traditional single-strategy access tree by transforming it into a multi-strategy access tree, achieving multi-level strategy formulation and effectively enhancing the efficiency of policy access and fine-grained access to re- sources. In addition, the solution solved the security issue of access control authorization in the Internet of Vehicles by introducing the Lagrange polynomial secret value recovery mechanism, which combined the secret value with the authorization token. through security analysis, it have proved that the solution has identity anonymity and message non-repudiation. Performance analysis reveals that, in comparison to other solutions, the scheme has lower storage overhead in the policy execution system by utilizing the multi-strategy access tree to store policies. Moreover, as the efficiency of policy matching increases, the computational overhead significantly diminishes, indicating that the solution is well-suited for secure and efficient resource access control in the context of the Internet of Vehicles. [ABSTRACT FROM AUTHOR]

Copyright of Multipurpose Utilization of Mineral Resources / Kuangchan Zonghe Liyong is the property of Multipurpose Utilization of Mineral Resources Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Mechanical Engineering is the property of Editorial Board of China Mechanical Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

近年来, 随着胰岛细胞可塑性相关研究取得的进展, 由此催生的内源性β细胞再生疗法 日益受到研究者的关注。内源性β细胞再生主要通过β细胞的自我复制、去分化的β细胞再分化、成 熟体细胞的转分化以及胰岛干细胞的分化。该文将简要介绍胰岛β细胞再生的方式及相关机制. [ABSTRACT FROM AUTHOR]

As the population ages, age-related diseases of the musculoskeletal system are becoming a serious threat to the health and quality of life of older people. Among them, osteosarcopenia is a common synergistic musculoskeletal degenerative disease among the elderly, predisposing them to falls, fractures, and even varying degrees of disability. In recent years, there has been increasing evidence that long-stranded non-coding RNAs (lncRNAs) play an important role in gene expression in bones and muscles. Therefore, in this paper, we review the regulatory roles and recent findings of lncRNAs in osteosarcopenia and explore the potential of lncRNAs as new targets and pathways for the diagnosis and treatment of osteosarcopenia in the future. [ABSTRACT FROM AUTHOR]

Copyright of Electroplating & Finishing is the property of Electroplating & Finishing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Pathophysiology is the property of Jinan University, School of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Railway Science & Engineering is the property of Journal of Railway Science & Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Digital Education is the property of Haiyan Publishing Co. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of the Chinese Society of Agricultural Engineering is the property of Chinese Society of Agricultural Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Mycosystema is the property of Mycosystema Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

AIM: To explore the role of interferon-induced protein with tetratricopeptide repeats 1 （IFIT1） in the development of cholangiocarcinoma （CCA）. METHODS: RT-qPCR and Western blot were used to evaluate the expression of IFIT1 at mRNA and protein levels, respectively, in various human cell lines, including a normal bile duct cell line and six distinct CCA cell lines. The level and prognostic value of IFIT1 were validated in human CCA and para-tumor tissues, accompanied by a comprehensive analysis of the pathological parameters and clinical significance of IFIT1. To ascertain the role of IFIT1 in CCA progression, we conducted CCK-8, colony formation and Transwell assays to investigate the impact of IFIT1 knockdown on the proliferation, migration and invasion of CCA cells in vitro. For in vivo experimentation, we chose HuCCT1, a human CCA cell line with a high metastatic potential, to create subcutaneous xenograft and lung metastatic tumor models in nude mice. We observed the effect of IFIT1 on the growth and metastasis of orthotopic CCA xenograft with IFIT1 knockdown. Gene set enrichment analysis （GSEA） of public databases was performed to reveal the underlying mechanism regulated by IFIT1 in CCA progression, which was subsequently confirmed by functional studies in vitro. RESULTS: Compared with normal bile duct cells, IFIT1 was significantly up-regulated in human CCA cell lines, particularly in HuCCT1 and QBC939 cells with higher metastatic potential, as well as in CCA tissues compared with para-tumor tissues（ P<0. 01）. Moreover, in a separate cohort of 44 CCA patients, up-regulated IFIT1 was positively correlated with tumor malignancy features such as tumor size, lymph node metastasis, TNM staging, and poor prognosis （P< 0. 01）. These results suggest that IFIT1 plays a crucial role in CCA malignancy. Functional analysis revealed that knockdown of IFIT1 effectively inhibited the growth and metastasis of CCA cells in vitro and in vivo （P<0. 01）. Bioinformatic screening analysis indicated that the Wnt/β-catenin pathway, an epithelial-mesenchymal transition （EMT）-associated signal pathway, was significantly enriched in CCA patients with up-regulated IFIT1. Consistently, knockdown of IFIT1 in CCA cells markedly inhibited Wnt/β-catenin activation, resulting in decreased EMT-related markers such as vimentin and Snail. CONCLUSION: IFIT1 promotes CCA progression through the enhancement of Wnt/β-catenin-mediated EMT, suggesting that IFIT1 may serve as an independent prognostic biomarker for CCA patients. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Inorganic Analytical Chemistry / Zhongguo Wuji Fenxi Huaxue is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of China Sciencepaper is the property of China Sciencepaper and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)