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Severe asthma is a chronic inflammatory disease that is not sensitive to glucocorticoid treatment. In the pathogenesis of severe asthma, T helper cell 17(Th17) and interleukin 17 (IL-17) play an important role, mainly by aggregating the infiltration of neutrophil to aggravate the severity of asthma. Methyl-CpG-binding protein 2 (MBD2) plays an important role in the differentiation of Th17 cells from naive CD4+T cells, positively regulate Th17 differentiation and IL-17 expression. MBD2 binds to the CpG islands in the promoter region of interferon regulatory factor 4 (IRF4), suppressor of cytokine signaling 3 (SOCS3), hypoxia-inducible factor-la (HIF-1α) and misshapen like kinase 1(MINK1), which leads to methylation, regulates the differentiation of Th17 cells, and participates in the pathogenesis of severe asthma. [ABSTRACT FROM AUTHOR]

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The rural revitalization strategy is an important measure put forward by the 19th National Congress of the Communist Party of China to solve the issues of agriculture, farmer and rural area and accelerate the modernization of agriculture and rural areas. Agriculture-related universities have unique advantages in the implementation of rural revitalization strategy and shoulder important missions. Taking Jilin Agricultural Science and Technology University as an example, the paper puts forward a new organizational model of “five combinations” for agricultural colleges to help implement the rural revitalization strategy, namely “online + offline”, “centralized + decentralized”, “school + enterprise”, “project + achievement”, and “workstation + industrial college”. It can provide reference for agriculture-related universities to serve the strategy of rural revitalization and provide new ideas and methods for rural revitalization and development. [ABSTRACT FROM AUTHOR]

Taking the construction of employment practice base of animal husbandry and veterinary specialty in Jilin University of Agricultural Science and Technology as an example, starting from problems in practice base construction, with improving the quality of application-oriented talent training as the center, how to better construct, manage and use the practice bases of agriculture-related universities in the context of new agricultural science was proposed. The campus practice base is used to carry out various forms of practical activities, such as student practical training projects, student professional associations, student innovation and entrepreneurship activities, interest group activities and skills competition training. Use off-campus practice base to carry out “order training, professional co-construction, school-enterprise interaction, on-the job practice” and other forms of school-enterprise cooperation personnel training model. From the implementation effect and the feedback of the employer, the comprehensive quality of the students has been greatly improved, the practical ability is more consistent with the job demand, and the “school-enterprise cooperation, the integration of industry and education” has been truly realized. [ABSTRACT FROM AUTHOR]

Objective To explore the possible mechanism of eucommia ulmoides leaves total flavonoids promoting neurological repair in rats with cerebral hemorrhage from the Ras homolog gene family member A (RhoA)/Rho-associated coiled-coil protein kinase (ROCK) pathway. Methods SD male rats were used to establish cerebral hemorrhage model by the modified double injection method, and they were randomly divided into the sham operation group, the model group, the eucommia ulmoides leaves total flavonoids group, the RhoA inhibitor group, the RhoA agonist group, and the eucommia ulmoides leaves total flavonoids + RhoA agonist group, with 20 rats in each group. The eucommia ulmoides leaves total flavonoids group was intragaically treated with 200 mg/kg eucommia ulmoides leaves total flavonoids. The RhoA inhibitor group was intraperitoneally injected with 1 mg/kg RhoA inhibitor Y27632. The RhoA agonist group was intraperitoneally injected with 30 µg/kg RhoA agonist U-46619, and the eucommia ulmoides leaves total flavonoids + RhoA agonist group was intraperitoneally injected with 200 mg/kg eucommia ulmoides leaves total flavonoids and 30 µg/kg RhoA agonist U46619. The model group and sham operation group were given 10 mL/kg normal saline once a day for 7 consecutive days. After the administration, the behavioral changes of rats were observed with the naked eye and the neurological deficit symptoms were assessed by the modified neurological severity score (mNSS). Brain tissue was taken and weighed, and the water content of the brain tissue was calculated according to the formula to evaluate the cerebral edema, then the brain tissue slices were prepared and the volume percentage of the cerebral hematoma was calculated according to the formula. Changes in the structure of nerve synapses in perihematoma tissue were observed by transmission electron microscope. Changes of neuronal apoptosis of perihematoma tissue were observed by TUNEL staining method. Changes in neuron skeleton of perihematoma tissue were detected by phalloidin staining. The expression levels of RhoA, ROCK, cytoskeleton protein (Factin), filament protein (cofilin), phosphorylated cofilin (p-cofilin), neuron and synapse growth promoting proteins [nerve growth factor (NGF), neurotrophic factor 3 (NT3), postsynaptic dense protein-95 (PSD-95), synaptophysin (SYP)] in perihematoma tissue were detected by Western blot assay. Results Compared with the sham operation group, the neurological deficit scores, water content of brain tissue and the percentage of cerebral hematoma volume were increased in the model group, the neuronal apoptosis, skeleton structure damage, and changes in the structure of nerve synapses in the surrounding tissue of the hematoma were severer, the activation of RhoA/ROCK pathway increased, and the expression of neuron and synapse growth promoting proteins decreased (P＜0.05). Eucommia ulmoides leaves total flavonoids or RhoA inhibitor intervention treatment could inhibit changes in neuron skeleton structure mediated by RhoA/ROCK pathway activation, increase the expression of neuron and synapse growth promoting proteins, alleviate neuronal damage and apoptosis in surrounding tissues of the hematoma after cerebral hemorrhage, and promote nerve function repair (P＜0.05). RhoA agonist could promote the activation of RhoA/ROCK pathway, aggravate the neurological damage after cerebral hemorrhage, and weaken the nerve function repairing effect of eucommia ulmoides leaves total flavonoids (P＜0.05). Conclusion Eucommia ulmoides leaves total flavonoids can improve the symptoms of cerebral hemorrhage in rats and promote the nerve function repair by inhibiting the activation of RhoA/ROCK pathway. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Forensic Medicine / Fayixue Zazhi is the property of Journal of Forensic Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Cotton Textile Technology is the property of Cotton Textile Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Tianjin Medical Journal is the property of Tianjin Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the practical application of IBS method in the full sibling testing． Methods PowerPlex R 21 System kit was used to amplify the 19 STR loci （D3S1358， D6S1043，D13S317， Penta E，D16S539，D18S51，D2S1338，CSF1PO，Penta D，TH01，vWA，D21S11，D7S820，D5S818， TPOX，D8S1179，D12S391，D19S433，FGA） from the 234 pairs of determined full siblings and 200 unrelated individuals of Han population in Yunnan province，and ABI3130 genetic analyzer automatic detection and Gene Mapper ID v3.2 software were used for STR genotyping．The typing results were calculated on the basis of the IBS method （SF/Z JD0105002-2014） ．Results The rate of full siblings was 82.91% ， and it was higher than 75% in the standard. 17.09% of the samples could not give tendentious opinions. The scores from 13 to 22 had 65 pairs of unrelated individuals， and it accounted for 32.50%.There were 135 pairs of less than 13 points that accounted for 67.50%. Conclusion The application of IBS method in the identification of full siblings in Yunnan has a high value in forensic medicine. [ABSTRACT FROM AUTHOR]