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提出了一种基于卖方灵活合同的绿电与绿证中长期联合交易机制，聚合商协商达成中长期绿电交易合同，并基于风、光出力预测误差，考虑现货市场交易的影响执行卖方灵活合同交割。同时，聚合商可通过绿证市场交易，完成绿证考核指标。为验证该机制的有效性，进一步构建了聚合商绿电-绿证交易均衡模型，并设计了基于Lp-Box ADMM（alternating direction method of multipliers，交替方向乘子法）的分布式求解算法。通过模拟算例分析，验证了所提方法的有效性并分析了对聚合商交易行为及成本/收益的影响。结果表明所提出的机制可以有效实现聚合商间的中长期绿电与绿证联合交易，促进中长期绿电合同的达成，实现绿电与绿证交易的有效衔接。

Diabetes cardiomyopathy (DCM) is a cardiovascular disease with structural damage and dysfunction of myocardium under the condition of glucose and lipid metabolism disorder in diabetes. The main pathological characteristics are ventricular hypertrophy, myocardial remodeling and cardiomyocyte death, which induce heart failure. DCM has become one of the main causes of death in patients with diabetes. As a pro-inflammatory programmed cell death pathway, pyroptosis mediated by inflammasomes is considered an important driver of chronic inflammation due to its excessive activation. Recently, it was found that the over activation of pyroptosis promoted the course of DCM and became the hub connecting the disorder of glucose and lipid metabolism in diabetes and myocardial injury. With the discovery of more and more roles of Traditional Chinese Medicine (TCM) in regulating pyroptosis, TCM affects the occurrence and development of DCM by regulating pyroptosis or protein expression, which has become a research hotspot of myocardial protection strategies in diabetes. This article reviews the mechanism of pyroptosis in DCM and the research progress of TCM monomers and compound prescriptions in regulating the process of pyroptosis in DCM, in order to provide new ideas and targets for clinical research and treatment of DCM. [ABSTRACT FROM AUTHOR]

To identify major genes and pathways involved in oxidative stress in heart failure by bioinformatics analysis. GSE120895 gene expression profiles are acquired from the GEO database. And GEO2R is used to identify differentially expressed genes. We intersect the differentially expressed genes with the oxidative stress-related genes screened in the Gene Card database to find the oxidative stress-related genes in heart failure. R software is used to conduct GO and KEGG analyses of differentially expressed genes. Module of PPI network and analysis of key genes using Cyto scape software. We employ GSE17800 gene expression profiles to confirm the expression of important genes. For important genes, medication interactions are predicted. We identify 52 differentially expressed genes that are up-regulated in response to oxidative stress. Five key genes (ACTB, STAT3, FN1, EDN1, and CAT) are selected as a result. These five genes are validated in the GSE17800 gene expression profile. 19 candidate medicines that might target important genes are subsequently predicted. This study employ bioinformatics to explore for distinct genes that may be important to oxidative stress in heart failure, and help to better understand the pathophysiology of heart failure and generates new therapeutic options. [ABSTRACT FROM AUTHOR]

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Copyright of Computer Measurement & Control is the property of Magazine Agency of Computer Measurement & Control and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate diagnostic and prognostic value of actin-binding protein ANLN in clear cell renal cell carcinoma （ccRCC） and its relationship with tumor microenvironment. Methods: Gene expression data and clinical data for ccRCC were downloaded from The Cancer Genome Atlas （TCGA）. Relationship between ANLN expression and clinicopathological features was assessed by Wilcoxon rank sum test and Logistic regression. Receiver operating characteristic （ROC） curve was used to assess diagnostic value of ANLN expression in ccRCC. Kaplan-Meier and Cox regression analysis were used to investigate effect of ANLN expression on overall survival. Gene set enrichment analysis （GSEA） was used to identify signaling pathways associated with ANLN in ccRCC. Relationship between ANLN expression and immune infiltration was analyzed by ESTIMATE algorithm, tumor immune estimation resource （TIMER） and CIBERSORT algorithms. Relationship between ANLN and drug sensitivity was calculated using CellMiner database. Results: ANLN expression was significantly upregulated in ccRCC tissues. ANLN expression in ccRCC was correlated with clinicopathological features. ROC analysis showed that ANLN had a high diagnostic value in ccRCC. High ANLN expression was significantly associated with poor prognosis. Multivariate Cox regression analysis showed that high ANLN expression was an independent risk factor for overall survival in ccRCC patients. GSEA showed that ANLN was associated with multiple signaling pathways. In terms of immunity, ANLN was closely associated with tumor microenvironment, immune infiltration and immune checkpoint molecules in ccRCC. ANLN expression was negatively correlated with sensitivity of most antitumor drugs. Conclusion: ANLN is a potential diagnostic and prognostic biomarker and immunotherapeutic target for ccRCC. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Shenyang Agricultural University is the property of Journal of Shenyang Agricultural University Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper summarized the integrated nursing of traditional Chinese and western medicine for a patient undergoing percutaneous coronary intervention (PCI) supported by intra-aortic balloon pump(IABP) for cardiogenic shock acute caused by anterior myocardial infarction. Key issues of nursing included symptomatic nursing, acupoint application, auricular point pressing therapy, oral care with Chinese herbal medicine were carried during the treatment period. The integrated nursing measures were potentially effective to improve the patient’s satisfaction and reduce the risk of complications. (本文总结1例急性前壁心肌梗死致心源性休克患者行急诊经皮穿刺冠状动脉内支架植入术(PCI)及行主动脉内球囊反搏(IABP)后的中西医结合护理方案, 包括对症护理、穴位贴敷、耳穴压豆、中药口腔护理等。中西医结合护理方案能有效提升患者的舒适度, 减少并发症的发生风险。)

[Objective] High value-added monosaccharides can be synthesized through multi-enzyme cascade reactions using starch or dextrin as substrates. In the reaction systems, sugar phosphatase catalyzes the irreversible dephosphorylation reaction of the phosphorylated sugar intermediates to generate the corresponding sugars. This work is aimed to mine the new sugar phosphatase and to characterize this enzyme. [Method] In this study, a gene with unknown function, named as TsPase derived from the thermophilic bacterium Thermoproteus sp.CIS_19, was obtained from gene mining and screening. TsPase was found to have sugar phosphatase activity after its heterologous soluble expression with Escherichia coli BL21（DE3）, purification and enzymatic characterization. [Result] TsPase has a Tm value of（80.3 ± 1.3）℃, while the optimal reaction temperature of 70℃ and pH of 4. Our study indicated that metal ion Mg2+ has a strong promoting effect on TsPase. With the substrate tagatose 6 phosphate kinetic constant Km is（2.40 ± 0.98）mmol/L, and the catalytic constant kcat is（102.50 ± 8.60）min-1. TsPase was integrated into an in vitro synthetic enzymatic biosystem for the one-pot production of D-tagatose from maltodextrin. The production of D-tagatose in the reaction equilibrium system was（4.26 ± 0.03）g/L and the conversion rate reach 42.6% ± 0.3%. [Conclusion] Overall, TsPase possesses fine thermal stability and activity, as well as high conversation rate in vitro synthetic enzymatic biosystem. These characteristics make it great value in future theoretical research and industrial production. [ABSTRACT FROM AUTHOR]

In this experiment, Cu-pyropheophorbide-a methyl ester (Cu-MPPa) was designed to be synthesized for cancer therapy mediated by reactive oxygen species (ROS) and glutathione depletion. Additionally, it facilitates the maintenance of high intracellular oxygen concentrations through cyclic oxygen production via a Fenton-like reaction. The reactive oxygen generation capacity, oxygen production capacity and glutathione consumption capacity of CuMPPa were investigated during the experiment. Mass spectrometry was used to characterize the structures of the synthesized intermediates. Combining Organic Chemistry synthesis, Instrumental Analytical Chemistry and Biochemistry experiments, this experiment necessitates a team of three students and is estimated to take about 24 credit hours. It is designed to cultivate students' abilities in synthesis and innovation, complex problem-solving and teamwork enhancement. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Northeastern University (Natural Science) is the property of Dongbei Daxue Xuebao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chemical Engineering (China) / Huaxue Gongcheng is the property of Hualu Engineering Science & Technology Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the expressions of H3.3G34W, p63 and SATB2 in giant cell tumor of bone (GCTB) and the effect and value of their combined application in the diagnosis of GCTB. Methods We collected the samples and medical records of 54 cases of GCTB and 83 cases of non-giant cell tumor of bone (14 cases of aneurysmal bone cyst, 16 cases of chondroblastoma and 53 cases of non-ossifying fibroma) diagnosed between 2020 and 2022 in the Department of Pathology of Honghui Hospital Affiliated to Xi'an Jiaotong University. The expressions of H3.3G34W, p63 and SATB2 were detected by EliVision immunohistochemical method. X² test was used to determine whether there are significant differences in the positive rates of H3.3G34W, p63 and SATB2 among all the groups. The combined diagnostic model including H3.3G34W, p63 and SATB2 was established by Logistic regression analysis, and the diagnostic value of the model was evaluated by ROC curve analysis. Results The positive rates of H3.3G34W, p63 and SATB2 in GCTB group were 81.5%, 90.7% and 92.6%, respectively; the positive rates in NGCTB group were 2.4%, 28.9% and 62.7%. Compared with NGCTB group, the age of GCTB group was significantly older [(41.222±14.849) vs. (16.566±9.439),P<0.001], and the prevalence was higher in women than in men (51.9% vs. 48.1%, P<0.001). In addition, compared with the NGCTB group, the positive rates of H3.3G34W (81.5% vs. 2.4%, P<0.001), p63 (90.7% vs. 28.9%, P<0.001) and SATB2 (92.6% vs. 62.7%, P<0.001) were significantly higher in the GCTB group. Univariate regression analysis built a univariate prediction model and ROC curve analysis showed that age (AUC=92.9%, P<0.001), sex (AUC=64.5%, P= 0.004), H3.3G34W positive rate (AUC=89.5%, P<0.001), p63 positive rate (AUC=80.9%, P<0.001) and SATB2 positive rate (AUC=65.0%, P=0.003) were independent predictors of diagnosis of giant cell tumor of bone. Multivariate regression analysis (Logistic) constructed a hybrid prediction model. ROC curve analysis suggested that the hybrid model showed better prediction value than the single factor model (AUC = 98.4%, P<0.001). Conclusion H3.3G34W, p63 and SATB2 are effective molecular markers for the diagnosis of GCTB, and their combined application can improve the prediction efficiency of the diagnosis of GCTB. [ABSTRACT FROM AUTHOR]

This paper summarized the nursing experience of one case of insomnia treated by intradermal needle therapy. Based on the acupoint selection by syndrome differentiation, the intradermal needle therapy combined with auricular acupuncture was carried out to relief patient’s anxiety states and improve sleep quality. (本文总结 1 例皮内针改善失眠患者睡眠质量的护理经验, 包括中医辨证、皮内针操作方法以及注意事项等。通过采用皮内针体针与耳针相结合辨证取穴的方法治疗失眠, 能有有效缓解患者焦虑情绪, 改善睡眠质量。)

Copyright of Electric Machines & Control / Dianji Yu Kongzhi Xuebao is the property of Electric Machines & Control and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Practical Medicine / Shiyong Yixue Zazhi is the property of Journal of Practical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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It takes a long time to treat ore samples by traditional alkali fusion and acid dissolution, and it is easy to cause environmental pollution. Microwave digestion directly releases energy to the sample with high efficiency, and volatile elements are retained in the digestion solution to prevent volatilization from causing deviation of results and environmental pollution. In this experiment, 0.2g of phosphate rock sample was taken and placed in a microwave digestion tank. 3mL hydrochloric acid, 3mL nitric acid, and 2mL hydrofluoric acid were added and then dissolved in the microwave digestion instrument. Then, 2mL of saturated boric acid solution was added for a further microwave digestion. After cooling, the sample was diluted in a 100mL volumetric flask with deionized water. Online addition of rhodium and rhenium as dual internal standards for inductively coupled plasma-mass spectrometry (ICP-MS) determination of rare earth elements in phosphate rock was performed. The relative standard deviation (RSD) of 15 rare earth elements was between 0.68% and 4.52%, the recovery was between 93.1% and 106.6%, and detection limit was between 0.003-0.029μg/g. Two phosphate ore samples were selected and compared with the mixed acid dissolution method. The relative standard deviation was −5.82%-5.99%. [ABSTRACT FROM AUTHOR]

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Organic framework compounds have great application potential in photocatalytic water hydrogen production due to the advantages of controllable molecular structure, large specific surface area, high porosity, dispersed chemical active sites and good stability. Tn this paper, the metal-organic framework NH-UiO-SS was introduced into the synthesis process of the covalent organic framework PyPD-COF by solvothermal method, and NHv-UiO-SS/PyPD-C'OF heterojunction was formed in situ. The samples were characterized by TEM, EDS, XPS, FTTR, UV-Vis and photocurrent analysis, as well as photocatalytic performance test. The constructed NH-UiO-SS/PyPDC'OF heterojunction could not only retain the excellent properties of the original MOF and COF components, but also form bonds at the heterogeneous interface. Tt is beneficial to promote interfacial charge transfer, reduce electron-hole recombination rate, and increase photocatalytic hydrogen production efficiency to 20.68 mmol/(h • g), which is 86 times and 3 times of the original NH2-Ui()-66 and PyPD-COF, respectively. At the same time, the covalent bond at the interface makes the composite sample have good hydrogen production stability, which provides a new strategy for the construction of efficient photocatalytic decomposition of aquatic hydrogen heterojunction photo catalysts. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Ordnance Equipment Engineering is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective To observe the structural changes of intestinal flora in breast-fed newborns with pathological jaundice and to provide the theoretical basis for the adjuvant treatment of neonatal pathological jaundice. Methods Thirty breastfeeding infants with pathological jaundice were selected as the observation group and 30 healthy newborns were selected as the control group. The fecal samples from two groups were collected. High-throughput 16S rRNA gene sequencing technology was used to detect RNA of fecal samples in the two groups, β diversity and operational taxonomic units (OTU) were used to analyze the diversity of intestinal flora, and LEfSe was used to screen the dominant intestinal flora (absolute value of LDA score>2), and PICRUSt analysis tool was used to analyze the biological function of intestinal flora. Results Compared with the control group, the number of bacteria OUT in the phylum, class, order, family, genus, species levels was small (all P<0. 05). Compared with the control group, Bacillus abundance was low at the order level, Citrobacter was high, Clostridium pratense was low at the genus level, and Bacaeroides fragilis was low at the species level (all P<0. 05). The dominant intestinal flora of the observation group was Clostridium butyricum, sphingoliomonas and sphingomonas, while the influential intestinal flora of the control group were Bacteroides fragilis and Tricilis. Compared with the control group, the intestinal flora abundance involved in mineral nutrient absorption, spore formation, D-arginine and D-ornithine metabolism, and polyketose unit biosynthesis functional pathways were lower in the observation group (all P<0. 05). The abundances of Clostridium pratense and Bacteroides fragilis were negatively correlated with serum total bilirubin and indirect bilirubin levels in children with neonatal pathological jaundice (all P<0. 05). Conclusion There is structural imbalance and functional differences of intestinal flora in breast-fed newborns with pathological jaundice, and the intestinal flora of children are mainly Clostridium pratense and Bacteroides fragilis. [ABSTRACT FROM AUTHOR]

In order to scientifically evaluate the building performance of sponge city and solve the issue that the evaluation method of sponge city performance is too subjective, this paper innovatively attempted to propose a new comprehensive sponge city building performance evaluation method based on data envelopment method and the principle of vector angle cosine. Firstly, the evaluation index system was built from the following six dimensions including water ecology, water environment, water resources, water security, system and implementation, and display degree. Then the weight of each index was obtained by applying the data envelopment method which could weaken the influence of the subjectivity of decision data to the weight of the index. Furthermore, the performance level of sponge city construction was obtained based on the variable of progress between the target to be evaluated and the desired target by utilizing the vector angle cosine method. Meanwhile, sensitivity analysis was conducted to effectively identify which factors were the most susceptible during the performance of sponge city building. Finally, the method was applied to the sponge city building performance evaluation of Hebi City, and the evaluation results were compared with the fuzzy analytic hierarchy process, grey correlation method, analytic hierarchy process and vector included angle cosine method. The results show that the evaluation results of this method are consistent with those of other methods, and the building performance level of Hebi sponge city is level Ⅲ, which belongs to the medium level. However, the relative error of the evaluation results of this method is smaller and more close to the reality and the rationality of the model is proved. [ABSTRACT FROM AUTHOR]

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