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目的分析45例临床确诊的法布雷病（AFD）患者的临床特征，同时应用超声心动图二维斑点追踪技术（2D-STE）评估法布雷病患者应变图像，以期探索法布雷患者心脏早期受累在超声心动图（UCG）上的表现。方法本研究为观察性研究。共纳入确诊为AFD的患者45例，根据UCG测量左室壁有无肥厚，分为左室壁肥厚组（17例，室间隔或左室后壁厚度≥12 mm）和无左室壁肥厚组（28例）。收集患者基线资料，并对所有患者进行常规UCG检查及二维斑点追踪超声心动图分析。应用TomTec工作站分析超声心动图图像，比较两组的临床基线资料、UCG常规参数及心肌应变特征。结果本研究共纳入45例AFD患者，年龄（32.33±16.11）岁，其中男性27例（60.00%）。左室壁肥厚组17例（37.78%），无左室壁肥厚组28例（62.22%）。45例患者的左室射血分数（LVEF）均正常（＞50%）。与无左室壁肥厚组相比，左室壁肥厚组患者的靶器官受累比例明显增加。与无左室壁肥厚组相比，左室壁肥厚组患者的E/A，平均E/E'明显升高（P＜0.05）；左室壁肥厚组的整体、心肌层、心内膜以及各节段的纵向应变（LS），周向应变（CS）及径向应变（RS）的差异均无统计学意义（P 值均＞0.05）。AFD患者心肌层的整体和各节段LS、CS的绝对值均低于心内膜的对应值（P 值均＜0.05）。AFD患者的中间段的LS、RS绝对值较基底段和心尖段高（P 值均＜0.05）。结论早期收缩功能障碍与左室壁厚度无明显关系。2D-STE心肌应变可以早期监测AFD室壁肌层受累较心内膜严重，而中间段受累较心尖段和基底段轻。

目前，我国食用植物油供给严重不足和消费过度并存，导致进口依存度高，2020年食用植物油自给率下降到31.5%，供给侧和市场风险加大。利用1965—2020年我国食用植物油消费等相关数据，对我国食用植物油消费需求侧和供给侧的变化、存在的风险进行了分析。根据健康中国战略要求和我国油料生产优势及发展潜力，提出了优化我国食用植物油消费需求侧和供给侧改革的对策，对进一步优化我国食用植物油消费格局、推动我国人民健康消费、改善我国油料供给能力和结构、保障我国食用植物油供给安全具有重要意义。 At present, Chinese edible vegetable oil supply is seriously insufficient and overconsumption, result in high import dependence. In 2020, the self-sufficiency rate of edible vegetable oil decreased to 31.5%, and the supply side and market risks increased. Using the relevant data of Chinese edible vegetable oil consumption from 1965 to 2020, the changes and the risks in the consumer demand side and supply side of edible vegetable oil were analyzed.According to the strategic requirements of healthy China, production advantages and development potential of oilseeds, the countermeasures were put forward to optimize the demand side and supply side reform of Chinese edible vegetable oil consumption, which is of great significance to further optimize the consumption pattern of Chinese edible vegetable oil, promote the healthy consumption of Chinese, improve the capacity and structure of Chinese oilseed supply, and ensure the safety of edible vegetable oil supply in China.

文章针对基于光纤自相位调制（SPM）效应和四波混频（FWM）效应的全光再生技术,分析了归零差分相移键控（RZ-DPSK）调制信号在SPM效应下再生的局限性,指出只有将相位调制转换为幅度调制才可用此方法实现;同时研究了利用FWM效应实现再生时,在保证转换效率的前提下泵浦光和信号光波长与零色散波长之间需要满足的关系,以得到适合再生的转移函数。

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OBJECTIVE: To explore the potential mechanism of Erchen decoction in the treatment of chronic atrophic gastritis based on network pharmacology and molecular docking. METHODS: Traditional Chinese medicine systems pharmacology database and analysis platform was used to predict the active components of Erchen decoction, GeneCards, online Mendelian inheritance in man and therapeutic target database were used to screen the related targets of chronic atrophic gastritis. The protein-protein interaction network was constructed by using STRING platform and Cytoscape 3. 8. 2. Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis and gene ontology functional enrichment analysis were performed on key targets through the DAVID platform. The binding degree of core active compounds to key targets was predicted by the SwissDock platform. RESULTS: Totally 127 key compounds, 246 component targets and 892 disease targets were identified in Erchen decoction, and 95 common targets were obtained by intersection of Erchen decoction and chronic atrophic gastritis. Key active components such as quercetin, kaempferol, baicalin, glycyrrhizin A, naringin, isorhamnetin and β-sitosterol were screened, and had good binding with 8 key targets such as protein kinase B1, tumor protein p53, interleukin (IL) 6, tumor necrosis factor (TNF), vascular endothelial growth factor A, IL-1β, prostaglandin G/ H synthase 2 and caspase 3. KEGG results showed that Erchen decoction in the treatment of chronic atrophic gastritis through multiple pathways including cancer signaling pathway, chemical carcinogenesis-activated oxygen species signaling pathway and TNF signaling pathway. CONCLUSIONS: Erchen decoction plays a synergistic role in the treatment of chronic atrophic gastritis through multi-component, multi-target and multi-signaling pathway, and the results of network pharmacology and molecular docking can provide basis for the subsequent treatment and research of chronic atrophic gastritis. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Cancer Biotherapy is the property of Editorial Office of Chinese Journal of Cancer Biotherapy and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective To explore the impact of manual stretching on the size changes of sternomastoid (SCM) tumor in congenital muscular torticollis (CMT). Methods Between May 2017 and May 2019, retrospective review was conducted for 209 CMT children with SCM tumor. There were 132 males and 77 females, respectively. The side of involvement, the first visiting age and the initial long diameter, short diameter and cross section area of the SCM tumor were compared between sexes. Three visits were recorded in 209 patients, of whom 71 had four visits. The long diameter, short diameter and cross section area of the SCM tumor were compared between different visits. According to the age at visiting, 141 cases were 1 month old, 67 cases were 2 months old, 91 cases were 3 months old, 51 cases were 4 months old, 49 cases were 5 months old, 58 cases were 6 months old, 32 cases were 7 months old, 39 cases were 8 months old, 22 cases were 9 months old, 16 cases were 10 months old, 11 cases were 11 months old, 118 cases were 12 months old, and 15 cases were older than 12 months old. The long diameter, short diameter and cross section area of the SCM tumor were compared between different age. The patients were divided into three groups according to the age when ultrasound demonstrated the tumor disappeared. Group Ⅰ: ≤ 6 months; Group Ⅱ: >6 months; Group Ⅲ: Still not disappeared at the final follow up. The demographic information, the initial long diameter, short diameter and cross section area of the SCM tumor and the total follow up time were compared within three groups. Results Initial long diameter, short diameter and cross-section area were (28.8±5.6)mm, (12.5±2.4)mm and (288.5±94.9)mm² respectively. No gender differences existed in initial visiting age [ (37.2±19.1) vs. (37.7±20.2) day, P=0.669], initial long diameter [ (29.0±5.6) vs. (28.6±5.6)mm, P=0.818], short diameter [ (12.6±2.4) vs. (12.2±2.3)mm, P=0.640]or cross-section area [ (293.5±96.8) vs. (280.0±91.0) mm², P=0.458].Long diameter [first time (28.9±5.6), second time (17.1±14.0), third time (5.9±11.4), fourth time (1.0±5.2)mm, P<0.001], short diameter[first time (12.4±2.4) second time (7.1±5.8), third time (2.4±4.7), fourth time (0.4±2.3)mm, P<0.001] and cross section area[first time (288.1±94.4), second time (157.6±146.4), third time (52.1±109.1), fourth time (9.4±53.7)mm², P<0.001]decreased gradually with elapsing visiting time and age. And 40.3% of tumors disappeared until an age of 6 months and this ratio spiked to 94.3% at Month 12.No differences existed in initial visiting age [ ( (36.0±18.9) vs. (38.4±20.6) vs. (37.1±14.0)day, P=0.701], left/right involved side[36∶46, 49∶56, 10∶11, P=0.918]or initial long diameter [ (28.5±5.4) vs. (28.7±5.8) vs. (30.7±5.0)mm, P=0.286]among three groups. Meanwhile, short diameter[ (11.9±2.3) vs. (12.6±2.3) vs. (13.6±2.4)mm, P=0.007]and cross-section area [ (273.5±90.6) vs. (291.3±94.4) vs. (335.0±98.5)mm², P=0.027]differed statistically among three groups. Gender ratio (male: female) increased from group Ⅰ to group Ⅲ (48∶35, 68∶37, 16∶5).However, the difference was insignificant ( P=0.277).Group Ⅲ had greater initial short diameter [ (13.6±2.4) vs. (11.9±2.3)mm, P<0.05]and cross section area[ (335.0±98.5) vs. (273.5±90.6)mm², P<0.05]than Group Ⅰand yet shorter follow-up time [ (6.9±2.3) vs. (10.7±3.1)m, P<0.05]than Group Ⅱ. Average age of disappearing tumor was greater in boys and that in girls [ (8.7±4.4) vs. (7.5±3.3)m, P<0.05]. Conclusions More than 90% of SCM tumors in CMT children may disappear within an age of 1 year if manual stretching is initiated within 3 months. Tumors disappear later in boys than girls. The dynamic process of SCM tumor may be evaluated more accurately after improving health tutoring and boosting follow-up compliance. [ABSTRACT FROM AUTHOR]

Objective To explore the distribution of allergens and the related factors in patients with allergic rhinitis (AR) in Taiyuan and its surrounding areas. Methods From January 2021 to December 2022, a total of 1 903 patients diagnosed as AR were investigated in the Allergy Clinic of Otorhinolaryngology Head and Neck Surgery, the First Hospital of Shanxi Medical University, including 983 males (51.7%) and 920 females (48.3%). AllergyScreen test (AS) was used to detect allergens in all patients, and the distribution characteristics of different kinds of allergens in patients with positive allergens were described. The influencing factors of AR were analyzed in combination with clinical data such as gender, age and visiting time. Results Among the 1 903 patients, the positive rate of Artemisia argyi (60.0%), ragweed (27.0%) and indoor dust mite combination (23.4%) ranked the top three. The most common allergens in male and female AR patients were Artemisia argyi and ragweed. The positive rates of Artemisia argyi, indoor dust mite combination, cat dander, shrimp/ crab, mixed fungi, dog dander, milk and beef/mutton were higher in female patients than in male patients. The positive rates of tree combinations, Platanus acerifolia/Fraxinus chinensis and Juniper/Birch were higher in males patients than in female patients. The positive rates of Artemisia argyi, short ragweed, cat fur shavings, tree combination, Houttuynia cordata, egg white and milk were higher in the ＜18 age group than in other age groups. The positive rates of Artemisia argyi, ragweed, mixed fungi, dog dander, peanut/soybean, cockroach, milk, Platanus acerifolia/Fraxinus chinensis, and Juniper/birch in different seasons were statistically significant. Conclusions In recent 2 years, the main AR allergens in Taiyuan and its surrounding areas were Artemisia argyi, ragweed and indoor dust mites combinations. The positive rates of different allergens varied by gender, age and season. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the effect of Polydopamine (PDA) compound coating on the bonding strength of zirconia and self - bonding resin cement 3M ESPE Rely X™ U200 and the change of bonding strength after aging test. Methods Zirconia specimens were treated with three different surface treatments: "sandblasting," "sandblasting + silanization," and "sandblasting + PDA composite coating." These treated zirconia specimens were then bonded to resin blocks using 3M U200. The samples were divided into three groups for immediate shear bond strength testing, thermocycling aging, and pH cycling aging followed by shear bond strength testing. Statistical analysis was performed on the bonding strength data of each group. Results The "sandblasting + silanization" group showed the highest bonding strength between zirconia and resin, with statistically significant differences (P < 0.05) The "sandblasting + PDA composite coating" group had slightly higher bonding strength than the "sandblasting" group, but the difference was not statistically significant (P > 0.05) After aging tests, all surface treatment groups experienced a significant reduction in bonding strength (P < 0.05) The "sandblasting + PDA composite coating" group exhibited the greatest decrease in bonding strength, which was statistically significant (P < 0.05) The decrease in bonding strength for the " sandblasting + silanization" group was slightly higher than that of the "sandblasting" group, but the difference was not statistically significant (P > 0.05) Conclusion The PDA composite coating did not effectively enhance the bonding strength between zirconia and resin cement. Its bonding strength and stability after aging were inferior to those of the silanization coating. [ABSTRACT FROM AUTHOR]

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Follicular fluid is the internal environment where follicular cells grow and proliferate, and the changes of its components are closely related to the functional status of follicular cells. In recent years, it has been found that exosome, a double⁃layer membrane vesicle with a diameter of about 30-150 nm, exists in many biological fluids, and its mediating role in many physiological and pathological processes has been revealed. The researchers also identified exosomes in follicular fluid and found that they are closely related to the growth and proliferation of follicular cells, indirectly influencing oocyte status, which is important for assessing oocyte quality. [ABSTRACT FROM AUTHOR]

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[Objective] To screen the highly efficient degradation strains of beta-cyfluthrin (β-CF), and study their degradation characteristics. [Method] Gradient pressure acclimation was used to enrich and screen candidate strains for degradating β-CF from soil that had been used pyrethroids, and the taxonomic status was identified by morphological characteristics and phylogenetic analysis based on 16S rRNA gene sequence. The tolerance and degradation characteristics of candidate strains to β-CF were investigated by single-factor experiments. [Result] A dominant strain GM4 with strong environmental adaptability was obtained by screening, and the strain was identified as Acinetobacter oleivorans. The tolerance concentration of strain GM4 to β-CF could reach 600 mg/L, and the degradation rate of β-CF was 99.44% after the initial concentration of 50 mg/L,pH 8.0, inoculation amount of 10%, and temperature of 28 °C for 48 h. [Conclusion] The GM4 strain can efficiently degrade β-CF, which is an excellent germplasm resource for the bioremediation of pesticide residues of β-CF in the environment. [ABSTRACT FROM AUTHOR]

Objective To explore the effects of prohibitin 2(PHB2) on sensitivity of non-small cell lung cancer cell line A549 to erlotinib (Erl) and its potential mechanisms. Methods RACK1-specific small interfering RNA was transfected in A549 cells for knocking-down of PHB2. The effects of PHB2 inhibition on cell proliferation and apoptosis induced by Erl were observed. The colocalization of microtuble-associated protein light chain 3 alpha (LC3) and mitochondria was visualized by MitoTracker staining and green fluorescent protein-microtuble-associated protein light chain 3 alpha (GFP-LC3) transfection. Cell proliferation was detected by 5-ethynyl-2′-deoxyuridine (EdU) staining. Cell colony formation was evaluated by colony forming assay. Apoptotic index of A549 cells was evaluated by TUNEL. Western blot was used to measure the expressions of PHB2 and LC3Ⅱ. Mitochondrial transmembrane potential, cytochrome c and respiratory chain complex Ⅰ/Ⅱ/Ⅴ activity were analyzed by the commercially available kits. Results Compared with the siPHB2 and siCtrl+Erl group, the EdU-positive A549 cells and the number of cell colonies decreased significantly (P＜0.05), while the TUNEL-positive A549 cells increased significantly(P＜0.05) in the siPHB2+Erl group. In addition, compared with the siPHB2 and siCtrl+Erl group, mitochondrial transmembrane potential and respiratory chain complex Ⅰ/Ⅱ/Ⅴ activity decreased significantly (all P＜0.05) and the levels of cytochrome c increased in mitochondrial fractions (P＜0.05) and decreased in cytosolic fractions(P＜0.05) in the siPHB2+Erl group. Conclusions PHB2 inhibition significantly improves sensitivity of A549 cells to Erl, which may be explained by inhibition of PHB2-mediated mitochondrial autophagy. [ABSTRACT FROM AUTHOR]

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To explore mechanism of prohibitin 2(PHB2) inhibition on the apoptosis of non-small cell lung cancer cell line A549. Methods For stable knockdown of PHB2, A549 strain was infected with lentiviruses. A549 cells with PHB2 depletion were incubated with Mdivi-1(DRP1 inhibitor). Apoptotic index of A549 cells was evaluated by TUNEL and annexin V-FITC/PI. Mitochondrial morphology was visualized by MitoTracker. ATP content, citrate synthase activity and the level of cytochrome c in cytosolic and mitochondrial fractions were analyzed by commercially available kits. Western blot was used to measure the levels of PHB2, DRP1 and p-DRP1 protein expression. Results Compared with the shCtrl group, the apoptosis of A549 cells increased significantly (P＜0.05) with up-regulated DRP1-dependent mitochondrial fission (P＜0.05), down-regulated ATP content (P＜0.05) and citrate synthase activity (P＜0.05). The level of cytochrome C was decreased in mitochondrial fractions (P＜0.05). Compared with the shPHB2 group, the apoptosis of A549 cells decreased significantly (P＜0.05) with alleviated DRP1-dependent mitochondrial fission (P＜0.05), increase of ATP content (P＜0.05) and citrate synthase activity(P＜0.05). The level of cytochrome C was increased in mitochondrial fractions (P＜0.05) in the shPHB2+Mdivi-1 group. Conclusions PHB2 inhibition can significantly enhance the apoptosis rate of A549 cells, potentially through promoting DRP1-dependent mitochondrial fission. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Central China Normal University is the property of Huazhong Normal University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Electric Machines & Control / Dianji Yu Kongzhi Xuebao is the property of Electric Machines & Control and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Strengthening the competitive advantage of manufacturing and promoting its high-quality development are the key points to build a modern industrial system. This study uses international market share (MS), revealed comparative advantage (RCA), trade competition index (TCI), and price index (PI) from 2005 to 2020 to analyze the evolution of manufacturing competitive advantage and its main sources in major countries. The main findings are as follows. China's labor-intensive industries maintain a strong international competitive advantage, and the international competitive advantage of some capital and technology-intensive industries is increasing. The capital and technology intensive industries in Germany, Japan, and United States have maintained a strong international competitive advantage, but some of them have shown a downward trend. The international competitive advantages of capital and technology-intensive industries such as electrical machinery and equipment manufacturing, special equipment manufacturing in China mainly come from product prices, while those in Germany, Japan, and United States mainly come from technology. Four policy suggestions are presented in this study for strengthening the competitive advantage of manufacturing: promoting technological innovation focusing on industrial basic capabilities; modernizing the manufacturing industry chain, supply chain, and innovation chain; accelerating digital, green, and service transformation; and increasing level of international cooperation and cross-border operations. [ABSTRACT FROM AUTHOR]

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