Objective: To investigate the prognosis and the influencing factors of restenosis after endovascular intervention in diabetes patients with lower extremity arteriosclerosis obliterans. Methods: 100 patients with diabetes complicated with arteriosclerosis obliterans of lower extremities admitted to our hospital from January 2022 to December 2022 were selected. All patients were treated with endovascular intervention, and the treatment conditions were analyzed. Then, the patients were followed up, and the number of patients with restenosis was recorded, A logistic regression model was established to analyze the independent influencing factors of short-term prognosis (good prognosis=0, poor prognosis=1) and occurrence of restenosis (non restenosis=0, restenosis=1) as dependent variables. Results: 100 diabetic patients with lower extremity arteriosclerosis occlusion were treated by endovascular intervention, the length of hospital stay was (13.43±2.42) d, the cost of treatment is RMB (73453.43±1253.64), the total response rate was 80.00%, The incidence of cardiovascular and cerebrovascular events was 5.00%, the amputation rate was 4.00%, the incidence of restenosis at 1-year follow-up was 25.00%; Significant difference between poor prognosis group and good prognosis group: age, duration of lower extremity arterioscle rosis occlusion, ankle-brachial index, fibrinogen, total cholesterol, smoking history, and combined hyperlipidemia (P<0.05),Fasting blood glucose, fibrinogen, total cholesterol, glycated hemoglobin, smoking history, hyperlipidemia, and chronic renal insufficiency between restenosis and non-restenosis patients (P<0.05); The factors affecting poor prognosis were age, ankle brachial index, fibrinogen, total cholesterol, and hyperlipidemia (P<0.05); the factors influencing treatment restenosis were fibrinogen, hemoglobin A 1 c, smoking history, hyperlipidemia, with chronic renal insufficiency (P<0.05). Conclusion: The total effective rate of endovascular intervention for diabetes patients with lower extremity arteriosclerosis obliterans is 80.00%, and the incidence of restenosis is 25.00%. Fibrinogen and hyperlipidemia are the common influencing factors for poor prognosis and restenosis, among which age, ankle brachial index, total cholesterol are also the influencing factors for poor prognosis, and the influencing factors for restenosis include glycosylated hemoglobin, smoking history, and chronic renal insufficiency. [ABSTRACT FROM AUTHOR]