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Copyright of Fudan University Journal of Medical Sciences is the property of Fudan University Journal of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Harbin University of Science & Technology is the property of Journal of Harbin University of Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To analyze the clinical feature, inflammatory state and disease activity of patients with Takayasu's arteritis (TA) complicated with elevated serum amyloid A (SSA). Methods Among 80 TA patients, the differences in clinical data, disease activity, inflammatory markers, cytokines and drug utilization were compared between SAA-elevating group and SAA-normal group by t test, rank sum test and Spearman's correlation analysis. Results SAA-elevating group had higher portion of Kerr's index≥2 (86.44% vs. 61.9%, P=0.036), higher level of erythrocyte sedimentation rate (ESR) ［(47.84±34.60) mg/L vs. (18.86±15.87) mg/L, P<0.001］ and high sensitivity C-reactive protein (hs-CRP) ［17.42(5.20-36.90) mg/L vs.1.80(0.75-4.05) mg/L, P<0.001］, platelet ［(295.00±95.60)×109/L vs. (240.85±75.78)×109/L, P=0.025］, globulin ［(29.05±6.49)g/L vs. (24.98±4.33) g/L, P=0.002］, IgG ［(13.37±4.52) g/L vs. (11.63±2.63)g/L, P=0.048］, C3 ［(1.26±0.26)g/L vs. (1.03±0.20)g/L, P=0.002］, C4 ［0.25(0.21-0.29) g/L vs. 0.20(0.14-0.23) g/L, P=0.008］ and IL-6［(10.64±8.93) pg/mL vs. (3.88±2.72) pg/mL, P=0.001］ compared with SAA-normal group. Conclusions TA patients complicated with elevated SSA have higher inflammatory index and disease activity, thus examination of SAA is necessary to reveal the inflammatory and disease status. [ABSTRACT FROM AUTHOR]

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) consists of autoimmune diseases characterized by necrotizing inflammation of small vessels and presence of ANCA. As a kind of life-threatening disease, AAV tends to involve a plenty of systems, and is subject to relapse even after complete remission. In this review, we focus on the latest progress of epidemiology, etiology, pathogenesis and clinical diagnosis of AAV. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Harbin University of Science & Technology is the property of Journal of Harbin University of Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)