崔晓萌, 陈慧勇, 丁振奇, 纪宗斐, 杨程德, 邹耀红, 达展云, 万伟国, 戴晓敏, 闫!焱, 孔秀芳, 马莉莉, and 姜林娣
Objective To analyze the clinical feature, inflammatory state and disease activity of patients with Takayasu's arteritis (TA) complicated with elevated serum amyloid A (SSA). Methods Among 80 TA patients, the differences in clinical data, disease activity, inflammatory markers, cytokines and drug utilization were compared between SAA-elevating group and SAA-normal group by t test, rank sum test and Spearman's correlation analysis. Results SAA-elevating group had higher portion of Kerr's index≥2 (86.44% vs. 61.9%, P=0.036), higher level of erythrocyte sedimentation rate (ESR) [(47.84±34.60) mg/L vs. (18.86±15.87) mg/L, P<0.001] and high sensitivity C-reactive protein (hs-CRP) [17.42(5.20-36.90) mg/L vs.1.80(0.75-4.05) mg/L, P<0.001], platelet [(295.00±95.60)×109/L vs. (240.85±75.78)×109/L, P=0.025], globulin [(29.05±6.49)g/L vs. (24.98±4.33) g/L, P=0.002], IgG [(13.37±4.52) g/L vs. (11.63±2.63)g/L, P=0.048], C3 [(1.26±0.26)g/L vs. (1.03±0.20)g/L, P=0.002], C4 [0.25(0.21-0.29) g/L vs. 0.20(0.14-0.23) g/L, P=0.008] and IL-6[(10.64±8.93) pg/mL vs. (3.88±2.72) pg/mL, P=0.001] compared with SAA-normal group. Conclusions TA patients complicated with elevated SSA have higher inflammatory index and disease activity, thus examination of SAA is necessary to reveal the inflammatory and disease status. [ABSTRACT FROM AUTHOR]