血清淀粉样蛋白A (SAA)升高的大动脉炎(TA)患者免疫炎症状态.

Objective To analyze the clinical feature, inflammatory state and disease activity of patients with Takayasu's arteritis (TA) complicated with elevated serum amyloid A (SSA). Methods Among 80 TA patients, the differences in clinical data, disease activity, inflammatory markers, cytokines and drug utilization were compared between SAA-elevating group and SAA-normal group by t test, rank sum test and Spearman's correlation analysis. Results SAA-elevating group had higher portion of Kerr's index≥2 (86.44% vs. 61.9%, P=0.036), higher level of erythrocyte sedimentation rate (ESR) ［(47.84±34.60) mg/L vs. (18.86±15.87) mg/L, P<0.001］ and high sensitivity C-reactive protein (hs-CRP) ［17.42(5.20-36.90) mg/L vs.1.80(0.75-4.05) mg/L, P<0.001］, platelet ［(295.00±95.60)×109/L vs. (240.85±75.78)×109/L, P=0.025］, globulin ［(29.05±6.49)g/L vs. (24.98±4.33) g/L, P=0.002］, IgG ［(13.37±4.52) g/L vs. (11.63±2.63)g/L, P=0.048］, C3 ［(1.26±0.26)g/L vs. (1.03±0.20)g/L, P=0.002］, C4 ［0.25(0.21-0.29) g/L vs. 0.20(0.14-0.23) g/L, P=0.008］ and IL-6［(10.64±8.93) pg/mL vs. (3.88±2.72) pg/mL, P=0.001］ compared with SAA-normal group. Conclusions TA patients complicated with elevated SSA have higher inflammatory index and disease activity, thus examination of SAA is necessary to reveal the inflammatory and disease status. [ABSTRACT FROM AUTHOR]