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急性抗体介导排斥反应 (AMR) 是一种未被充分认识的同种异体移植排斥反应, 是导致移植物功能损伤 的重要原因。但目前AMR早期诊断和临床管理仍面临较多困难。在器官移植过程中, 机体和移植物可能会出现不 同程度能量代谢失衡, 从而引起细胞、组织或器官的代谢特征改变, 继而影响其正常的结构和功能。AMR发生后, 免疫细胞能量代谢失衡可导致免疫功能紊乱, 进而引起移植物损伤; 当长时间经历低氧环境后, 移植物出现能量代 谢失衡, 移植物细胞将暴露新的抗原表位, 继而被免疫系统识别并清除, 诱发或加重移植后排斥反应, 从而对移植物造 成不可逆性损伤; 膜外三磷酸腺苷二磷酸水解酶1、缺氧诱导因子1等影响能量代谢的分子可通过催化底物分解和结 合细胞特定靶点调节机体代谢水平, 改变移植物细胞能量代谢失衡进程, 从而影响移植物长期预后。深入探索AMR 中能量代谢失衡致移植物损伤的机制, 对促进器官移植术后AMR的预防和治疗具有重要意义。 [ABSTRACT FROM AUTHOR]

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Anhui Agricultural Sciences is the property of Journal of Anhui Agricultural Sciences Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Fly Ash Comprehensive Utilization is the property of Hebei Fly Ash Comprehensive Utilization Magazine Co., Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Computer Engineering & Applications is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to explore the effect of badger oil at different doses on the improvement of atherosclerosis in hyperlipidemic mice, the hyperlipidemic mice model was established with high- fat emulsion. Different doses of badger oil were administered to the stomach for 14 days. Simvastatin was used as the positive drug control. Through detecting the contents of the total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) in the serum of mice, analyzing the index of the atherosclerosis index (AI1, AI2) and coronary heart index (R-CHR), the test studied the protective effects of high, medium and low doses of badger oil on atherosclerosis in hyperlipidemic mice. The results showed all the high, medium and low doses of badger oil had different degrees of improvement effects on atherosclerosis in hyperlipidemic mice. Compared with the hyperlipidemic model group, the contents of TC, TG, LDL-C, AI1 AI2 and R-CHR in serum were significantly decreased (P<0.01), and HDL- C levels were significantly increased (P<0.01). Badger oil had protective effect on atherosclerosis in hyperlipidemic mice. [ABSTRACT FROM AUTHOR]

Copyright of Nankai Business Review is the property of Nankai Business Review Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The molecularly imprinted polymers (MIPs) for human serum albumin (HSA) are prepared via metal-free visible-light-induced atom transfer radical polymerization (MVL ATRP) on the surface of Pt ultramicroelectrodes (Pt UME) that have been covered with electrodeposited nano gold (nAu) . In the preparation process, the fluorescein isothiocyanate labeled HSA (FITC-HSA) is used both as template molecules of MIPs and the catalyst of MVL ATRP. The obtained MIPs/nAu/Pt UME electrode is characterized by scanning electron microscope, energy dispersive X-ray spectroscopy, cyclic voltammetry, electrochemical impedance spectroscopy and X-ray photoelectron spectroscopy. Furthermore, platinum microelectrode works as the reference electrode, MIPs/nAu/Pt UME is used as working electrode and platinum wire is used as the counter electrode, a microvolume detection system of only 5 μL is constructed and used to detect HSA by differential pulse voltammetry method. Under the optimal conditions, the MIPs/nAu/Pt UME electrode (sensor) could determine HSA in the linear range from 1. 0×10-9 to 1. 0×10-2 mg/L with a detection limit of 3. 4×10-10 mg/L (S/N=3), and the correlation coefficient of 0. 9980. With hemoglobin, myoglobin, mouse IgG and bovine serum albumin (BSA) as interferers, MIPs/nAu/Pt UME electrode shows good selectivity toward HSA. The reproducibility and consistency of the sensor is also investigated. Finally, the actual samples of human serum are determined by the standard addition method. The obtained recovery of HSA is from 96. 0% to 104. 5%, showing its potential applications in clinical and diagnostic research. [ABSTRACT FROM AUTHOR]

神经源性膀胱是由于神经系统功能紊乱而导致的下尿路功能障碍，可引起尿频、尿急、尿失禁、膀胱排空 不全等症状或体征，同时还可导致多系统并发症，严重者可出现肾衰竭甚至死亡。骶神经电刺激（SNS）是治疗神经 源性膀胱的安全、有效方法，但 SNS 对骶孔的精确定位一直是个临床难题，而传统的定位方法穿刺精准度有限。因 此，需要精确且安全的辅助定位方法来协助 SNS 治疗神经源性膀胱。目前，除了传统X线定位技术外，应用于临床 的神经源性膀胱 SNS辅 助定位技术主要有超声引导技术、CT 联合 C 型臂引导技术和 3D 打印技术，各技术均有优势 和不足，而新兴辅助定位技术如多层螺旋 CT 技术、多模态影像技术、全息影像技术、SonixGPS 电磁定位超声导航技 术和医学影像+人工智能技术，尚未在临床上应用，但其应用前景较好，值得进一步研究探索。 [ABSTRACT FROM AUTHOR]

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